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A paper published this week in Immunity, a leading research journal highlighting discoveries in immunology by Cell Press, lays the groundwork to better understand and treat Crohn’s disease, a type of Inflammatory Bowel Disease (IBD). Beneficial interactions among intestinal cell types limit the harmful effects of a dysregulated gut microbiota, which is comprised of trillions of bacteria, viruses, and other microorganisms. These cell-cell interactions are essential to maintain a healthy gut and dysregulation of this cellular “crosstalk” can predispose the development of IBD.

Pawan Kumar

Led by Pawan Kumar, BVSc, PhD, of the Renaissance School of Medicine at Stony Brook University, the research identified a new role for Interleukin-17A (IL-17A), an immune cell-derived cytokine, in promoting selective epithelial cell development as well as limiting inflammation during colitis.Although drugs that target IL-17A are highly effective against psoriasis, an autoimmune condition, the same drugs result in adverse effects when used to treat the inflammatory responses of Crohn’s. While targeting IL-17A may reduce the pathogenesis of certain inflammatory responses, it is unclear why these treatments had opposing effects in Crohn’s patients. The research team has addressed this underlying question.

“We identified a new role for IL-17A in the intestinal inflammatory process by regulating a type of stem cell (Lgr5+) and progenitor cell function,” said Kumar, Senior Author and an Assistant Professor in the Department of Microbiology and Immunology. “We found that IL-17A acts on intestinal stem cells to promote secretory cell lineage commitment. In addition, impaired IL-17A signaling to secretory cells (ATOH1+) exacerbates colitis.

The research team tested their findings in different murine models. Upon collaborating with Ken Cadwell of New York University, they confirmed their results in human organoids. They found that IL-17A stimulated secretory cell differentiation in cystic human intestinal organoids.“Our data suggest that there is a ‘cross talk’ between immune cells and stem cells that regulates secretory cell lineage commitment and the integrity of the mucosa,” summarizes Kumar.

The authors believe their findings will help further research and lay the groundwork for future clinical studies that investigate the therapeutic potential of IL-17A and/or its downstream effector proteins.This research is supported in part by the National Institute of Diabetes and Digestive and Kidney Diseases, the Crohn’s and Colitis Foundation, the SUNY Research Foundation and a National Science Foundation Graduate Research Fellowship.

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A winning lottery ticket was purchased last week at the Village Grocery. Photo from Pixabay

The New York Lottery recently announced a second prize-winning ticket for the Feb. 9.

New York LOTTO drawing was sold at the Village Grocery on Main Street in Port Jefferson. The prize-winning ticket is worth $68,895.

The winning numbers for the Feb. 9 New York LOTTO drawing are 13 – 18 – 29 – 32 – 39 – 47 and Bonus Number 42. 

The winning ticket matched five of the six numbers and the bonus number. The jackpot for the drawing to be held on Feb. 12 is $4.2 million.  

To win the New York LOTTO jackpot, players must match six numbers drawn from a field of one to 59. New York LOTTO drawings are televised every Wednesday and Saturday at approximately 11:21 p.m.

A New York LOTTO prize of any amount may be claimed up to one year from the date of the drawing.

The Town of Smithtown successfully distributed over 2000 at-home Covid test kits to the most vulnerable population within the township. On Wednesday, Feb. 9, Town staff picked up 2,552 test kits from Suffolk County at the Department of Fire, Rescue and Emergency Services. On Thursday, Feb. 10, Smithtown Officials delivered approximately 2000 tests to seniors and at-risk individuals within the community, and at the Senior Center. On Monday morning, Feb. 14, the Department of Public Safety orchestrated a distribution event, where residents could collect their at-home tests outside of the Maple Avenue building.

“I’m extremely grateful to our partners in government at Suffolk County for arranging the much needed supply to be distributed to our residents, especially those who need it most. Our community members who are retired or living on a fixed income have certainly felt the cost of inflation, and this pandemic, in ways that have severely reduced quality of life. No one should have to sacrifice nutrition or grocery budgets to purchase PPE like face masks and covid tests. We owe it to our most vulnerable to provide the resources necessary to keep everyone healthy. While I hope the latest wave of the omicron variant was the last peak of Covid-19; these test kits will go a long way towards keeping people safe while cases are on the decline,” said Supervisor Ed Wehrheim.

The At-Home Covid-19 Antigen test kit (made in the USA) which includes two tests per box, were delivered to senior living communities throughout the township, at the Senior Center and at Public Safety. Supervisor Wehrheim’s office worked alongside Legislators Kennedy and Trotta to ensure locations were not replicated with the Legislators drop off locations and distribution events, to maximize the reach. When supplies ran out late on Monday morning at Public Safety, Legislator Robert Trotta generously allotted additional kits for the remaining residents.

Suffolk County will continue to work with the Town of Smithtown to provide additional Covid-19 related resources & PPE supplies for anyone in need. Residents who may be homebound, or are unable to obtain at-home test kits may email the Supervisors office at [email protected] with requests. For additional information on future at-home test kit distribution events within the township, residents can download the Town of Smithtown Mobile App, available for free on Google Play and the App Store.

Did You Know?

Residential households in the U.S. can order one set of four (4) free at-home tests through the US Postal Service. You can obtain a free at-home test kit by visiting covidtests.gov or by calling 1-800-232-0233 (TTY 1-888-720-7489).

Photo from Stony Brook Athletics

The Stony Brook University men’s track and field team competed in the Bruce Lehane Scarlet and White Invitational on Feb. 5 at Boston University.

Coach Andy Ronan with Robert Becker.
Photo from Stony Brook Athletics

Senior Robert Becker has been breaking records ever since he got to Stony Brook. He took it to the next level by becoming the first student-athlete to run a sub-4-minute mile in program history. Becker clocked in at 3:58.98 in the mile run setting a new personal best and breaking the previous mile record (4:02.45) that was also set by himself in 2020 at the ECAC/IC4A Indoor Championships. Becker’s record-breaking time also qualifies the senior for the IC4A Championships.

“Robert Becker made history today at the Bruce Lehane Scarlet and White Invitational by becoming the first Stony Brook student-athlete to break the 4-minute mile. Rob ran 3:58.98 to achieve this great moment in his career. It is truly a landmark performance, one that many chase but never attain – Rob has joined an exclusive club. There were many super performances today, career bests, and IC4A/ECAC qualifiers were the nature of the day,” said head coach Andrew Ronan. 

“Considering the news that we received earlier this week about being ineligible for the conference championships, we had a great meet. This group of athletes pulled themselves together, got focused, and showed the kind of quality performances that could have been on display at the conference championship meet,” he added.

The Seawolves are back in action on Feb. 11 when they compete in the Fast Track National Invite on Staten Island.

Organic Krush, an organic eatery with locations in Connecticut, New York and Virginia, has announced a partnership with Stony Brook University Athletics which includes a unique opportunity to fuel the athletes within the athletic arena, giving them direct access to healthy organic meals pre-and post workout. 

Krush worked directly with George Greene, Associate Athletic Director of High Performance and Competitive Success at SBU, to create the program, working together to select dishes based on macro-micro nutritional value, satiety and calories as well as variety, ultimately providing the athletes fueling options that reduce their body burden and allow then to train efficiently.

“Healthy clean eating is the wave of the future for athletes” said Michelle Walrath and Fran Paniccia, co-founders of Organic Krush. “As moms and parents of college athletes, we know the importance of food as fuel. Access to great tasting organic and plant based food can be difficult for college athletes. We started Organic Krush to make healthy food accessible to all. Our partnership with SBU Athletics gives us the opportunity to showcase the benefit of healthy eating to young athletes!”

“Organic Krush is the perfect partner for our athletes” said Greene. “Our goal is to keep our athletes healthy and strong on the field, court, track, and pool. Giving our athletes healthy balanced meals and uniting the passionate fans of SBU with the power of Organic Krush is a slam dunk for us! We are excited to welcome a partner that shares our commitment to improving the lives of our student-athletes as well as in the local community.”

Krush recently opened its 10th store around the corner from the Stony Brook University campus at 1111 Route 25A.

The partnership will kick off with a “Fuel Up with Krush” campaign echoing the importance of eating well for performance. Digital activations and event integrations spotlighting Organic Krush during games and events as well as a community-based summer fun run are planned.

Pictured: Ken Kutner (standing left) of the Suffolk County Office of Emergency Management; Legislator Stephanie Bontempi (standing center) and Legislator Rob Trotta (standing right) during the presentation’s opening remarks.

Legislators Stephanie Bontempi (Centerport) and Rob Trotta (Fort Salonga) recently held an emergency preparedness program that was open to the community at the Northport Public Library.  The training was led by Ken Kutner of the Suffolk County Office of Emergency Management.  Kutner has an extensive background in the field, most notably via his decades of service in the East Northport Fire Department in addition to his work with the County.

Some of the topics covered were the weather outlook for the region in 2022, putting together basic preparedness lists for homes and automobiles, ways to stay informed during emergencies and how to volunteer with emergency organizations.  Some people in attendance were unaware of what it takes to be prepared for a variety of potential emergencies.  Similarly, others were happy to learn that so many free resources are available to stay informed, such as handy emergency-related cell phone apps.

“This training is really a must for everybody, even for those who think they are already sufficiently prepared for what life throws our way.  I was surprised to learn that I need to take some steps to improve my family’s ability to be ready and have more peace of mind.  It’s never too early to get these things in order,” said Bontempi.  “If someone has not attended a program like this, seeking one out in the near future is highly recommended,” added Bontempi.

Those who are interested in learning more about the resources and opportunities mentioned above should visit: https://suffolkcountyny.gov/Departments/FRES.

Stock photo
Police Officer Glen Ciano

Suffolk County Executive Steve Bellone, Suffolk County Police Commissioner Rodney K. Harrison and Commack Fire District Commissioner Pat Fazio joined Susan Ciano, widow of Suffolk County Police Officer Glen Ciano, and representatives from New York Blood Center during a press conference on February 10 at the Commack Fire Department to announce the 12th annual blood drive named in memory of Police Officer Glen Ciano on Saturday, Feb. 12.

There has been a chronic shortage of blood supplies in New York since the start of the pandemic and the recent blizzard resulted in 1000 fewer donations due to blood drive cancellations and low donor turnout. Blood supplies remain below the ideal five-day safety level, and types O-, O+ B- and A- continue to hover at less than two-day levels.

The annual event is held in honor of Officer Ciano, who was responding to a call when he was killed by a drunk driver in Commack on February 22, 2009.

The 12th annual Glen Ciano Blood Drive will be held at the Commack Fire Department, located at 6309 Jericho Turnpike in Commack, on February 12 from 8 a.m. to 5 p.m. 631-499-6690.

Long Island based nonprofit’s service dog In training to play on Team Fluff In Animal Planet’s Puppy Bowl XVIII

America’s VetDogs, a Long Island based national non-profit that trains and places guide and service dogs with veterans and first responders with disabilities, is thrilled to announce future service dog in training “Kirby” will be competing in this year’s Puppy Bowl XVIII on Animal Planet on Super Bowl Sunday, February 13th at 2 p.m. Kirby will be one of more than 100 adoptable puppies running around and scoring touchdowns for a chance to win the “Lombarky” Trophy. The Puppy Bowl pre-game show begins at 1 p.m. with the game to follow at 2 p.m. They will air on Animal Planet and stream on Discovery+.

On Saturday, February 12, Kirby will be taking over Animal Planet’s Instagram for a “day in the life” feature of what it’s like to be puppy co-raised by NFL team Houston Texans and what training goes into raising a future service dog for a disabled veteran or first responder.

Kirby, a male Labrador retriever, joined the Houston Texans last July at 10 weeks old and was named by Texans fans through a voting contest. He is currently training to be a service dog in a partnership with America’s Vet Dogs. Once his training is complete, Kirby will be placed with a veteran or a first responder with disabilities. You can follow Kirby’s puppy raising journey but visiting his Instagram page at @Texanspup or @americasvetdogs.

Metro photo

Theatre Three in Port Jefferson will host a food and personal care items drive to benefit the Open Cupboard Pantry at Infant Jesus Church on Sunday, Feb. 13 from 9 a.m. to noon. Items will be collected at the Infant Jesus convent building at 110 Hawkins St. (off Myrtle Ave) in Port Jefferson.

Donations needed include juice, mustard, mayonnaise, ketchup, sugar, Maseca corn flour, cooking oil, coffee, pancake mix (complete), pancake syrup, healthy snacks as well as shampoo, conditioner, soap, deodorant, toothbrushes, toothpaste, razors, toilet paper, baby shampoo, baby wash, baby wipes, baby powder, Desitin and lotion. Grocery store gift cards and cash also accepted. For more information, call 631-938-6464.

The Long Island Museum recently acquired 'Fellowship Night' by Cyril Arthur Lewis for its permanent collection. Photo from LIM

The Long Island Museum (LIM) in Stony Brook has announced a long-range plan to improve diversity and equity in the museum’s permanent collection.

In December 2021, the LIM’s Board of Trustees and Collections Committee approved an initiative to enhance the multi-ethnic and multicultural representation of all Long Island residents in its permanent collections. In a Collections Development Initiative to improve diversity in its collections, LIM will work towards a five-year goal to build a much more inclusive holding of art and historical objects from Long Island’s diverse communities. In an initial move in this effort, the Museum purchased the oil painting Fellowship Night, c. 1940, a work depicting a Long Island Black church, by Cyril Arthur Lewis (1903-1994).

LIM is beginning this focused institutional priority to better connect with, represent and share the stories, histories, and art of all of Long Island’s residents. By 2027, LIM is aiming to have made significant strides towards building a more inclusive collection that has much stronger, deeper representation of Long Island’s diverse populations of Latinx, Black, Native American, and Asian American communities (sometimes referred to as “BIPOC,” which stands for Black, Indigenous, and People of Color, referring to Black, Native, Latinx, and Asian Americans).

“We are making large strides to have our collections meet our programming efforts,” said Deputy Director Joshua Ruff, citing such recent exhibitions as Long Road to Freedom: Surviving Slavery on Long Island (2019) and education programs like Vehicles for Change, a popular LIM Education program (grades 4-8) which explores the life and activism of 19th century Civil Rights pioneer Elizabeth Jennings Graham, using a streetcar from its Carriage Collection. 

“This is vital to the Museum’s future. It is crucial for us to ensure that our collection properly reflects and shares the history of all diverse communities that have lived, worked hard, struggled, and celebrated here on Long Island throughout our collective history,” said Ruff.

The Museum has well-regarded permanent collections in its Art, History, and Carriage Museums, highlighted by an important and large costume and textile collection of 10,000 artifacts, from the 1780s to the 1990s; the paintings, drawings, and archives of significant American genre painter William Sidney Mount (1807-1868); and nearly 200 horse-drawn vehicles of every description, which help to tell the story of American transportation in the age before automobiles. This initiative will add to these strengths by adding the inclusion of artists or historical objects that help to document Long Island’s resident communities of color.

The acquisition of Fellowship Night, which LIM purchased from South Bay Auctions in December, aids in this process. 

Born in Birmingham, England, Cyril Arthur Lewis emigrated to the U.S. in 1927, settling in Brooklyn. In 1937 he moved to East Williston and began painting and sketching local landmarks. Depicting an African American church during a nighttime event in this painting, he spotlights a building that was an important social center for the Black communities that developed on Long Island in the decades following the end of slavery in 1827.

In order to improve LIM’s collections diversity, the Museum will develop a collections advisory panel composed of external subject matter experts to periodically counsel and work with LIM’s curatorial department and Collections Committee. The Museum will also develop future exhibitions about Long Island’s diverse populations, such as a project next year that details the history of Sag Harbor’s historic Black Arts community, and make specific targeted appeals through Social Media and other community outreach efforts to help promote new donations to the collection.

“This is a long-term effort,” said Joshua Ruff. “But it is one we believe in down to our bones, one that we are fully committed to.”

ABOUT THE LONG ISLAND MUSEUM:

Located at 1200 Route 25A in Stony Brook, the Long Island Museum is a Smithsonian Affiliate dedicated to enhancing the lives of adults and children with an understanding of Long Island’s rich history and diverse cultures. The LIM will reopen for the spring season with new exhibitions on Thursday, March 3, 2022. Hours are Thursday through Sunday from noon to 5 p.m. For more information, visit www.longislandmuseum.org.