Columns

Stitch the Red-Tailed Hawk is just one of many raptors living at Sweetbriar Nature Center in Smithtown. Photo by John Davis

PROGRAMS

Crafternoon at the Library

Children ages 3 to 12 are invited to drop by Emma Clark Library, 120 Main St., Setauket  on May 27 between 1:30 and 3:30 p.m. to make a patriotic owl ornament. Free and open to all. No registration required. Questions? Call 631-941-4080.

Superheroes of the Sky

Sweetbriar Nature Center, 62 Eckernkamp Drive, Smithtown presents Superheroes of the Sky on May 27 from 11 a.m. to noon. Take a walking tour with Jim while he feeds the Center’s Birds of Prey and tells you about their incredible adaptations that help them survive in the wild. You’ll be seeing and learning about bald eagles, turkey vultures, owls, hawks and many more. Fee is $10 per adult,  $5 per child age 11 and under. To register, visit www.sweetbriarnc.org. 

Open Play at the Explorium

Join the Long Island Explorium, 101 East Broadway, Port Jefferson for Open Play on May 27, 28 and 29 from 1 to 5 p.m. with hands-on activities, crafts, and more. Admission is $5 per person, Long Island Explorium members and children under 1 are free. Call 631-331-3277 for further details.

Code Breakers 

Head over to the Whaling Museum, 301 Main St., Cold Spring Harbor this week for a game of Code Breakers during gallery hours Thursday to Sunday from 11 a.m, to 4 p.m. Uncover the secrets of maritime communication in this self-guided adventure. Hunt for hidden messages around the museum and decode clues left by mariners, using Morse Code, semaphore, and signal flags. Complete your trail by decorating your own personal flag to take home. For ages 6 and up. Admission fee plus $10. Call 631-367-3418.

THEATER

‘Cinderella’

Theatre Three, 412 Main St., Port Jefferson closes its children’s theatre season with its original retelling of the poor waif Cinderella from May 27 to June 17 with a sensory sensitive performance on June 4 at 11 a.m. The classic love story finds its power in a pumpkin, a palace, a prince and a young girl whose belief in herself can overcome any obstacle. When her Fairy Godmother adds a dash of excitement, the magical possibilities are endless. Don’t miss this musical enchantment for the entire family. All seats are $10. To order, call 631-928-9100 or visit www.theatrethree.com.com.

‘Flat Stanley’

John W. Engeman Theater, 250 Main St., Northport presents The Musical Adventures of Flat Stanley from May 28 to July 2 with a sensory friendly performance on June 10 at 11 a.m. Stanley Lambchop is an ordinary ten-year-old who longs to travel the world and do something amazing! Careful what you wish for, Stanley! One morning, Stanley wakes up really, REALLY flat! In a whirlwind musical travelogue, Stanley scours the globe for a solution to his unusual problem. He’s stamped, posted and mailed from Hollywood to Honolulu and beyond hoping to once again become three dimensional. All seats are $20. To order, call 631-261-2900 or visit www.engemantheater.com.

FILM

‘The Muppets Take Manhattan’

Cinema Arts Centre, 423 Park Ave., Huntington continues its Cinema for Kids! series with a screening of The Muppets Take Manhattan on May 28 at noon. When Kermit the Frog and friends start a stage act, they decide to take the show from their college town to Broadway. Rated G. Tickets are $12, $5 children 12 and under. Visit www.cinemaartscentre.org.

‘We Are Guardians’

The Suffolk County Vanderbilt Museum’s Reichert Planetarium, 180 Little Neck Road, Centerport has just premiered a new show, We Are Guardians. Audiences take a journey into, under, and around the many ecosystems across our planet and discover how each component fits together, and how the health of each part is vital to the health of Planet Earth. Find out how, with the help of satellites and scientific study, we can understand the links between human activities and climate change, and what we can do to work together to improve the health of our shared home. For ages 8 and up. For tickets and more information, visit www.vanderbiltmuseum.org.

Tom Manuel Photo by Adam Hurewitz

By Thomas Manuel

From the ancient Greeks to Ben Franklin, Andrew Carnegie, George Clooney, Bill Gates, and countless individuals in between, philanthropy, a love for humanity and a desire to see it thrive, has been a common thread. It has been said that effective philanthropy requires a lot of time and creativity; the same kind of focus and skills that building a business requires. Miriam Beard once pointed out, “The results of philanthropy are always beyond calculation.”

Philanthropic giving is not just a phenomenon found in certain parts of the world, rather it is a spirit of giving back which is global. Former Prime Minister Tony Blair of Great Britain in speaking about philanthropy expanded that the best philanthropy is not just about giving money but giving leadership. The best philanthropists bring the gifts that made them successful — the drive, the determination, the refusal to accept that something can’t be done. These are the characteristics they invest  into their philanthropy.

There are many reasons that drive and motivate philanthropy and not all are fueled by great passion for causes or humility. For every person that seeks anonymity there is another who desires their name be etched in stone. Regardless the motivation, our society at large has been beneficiary to philanthropic giving since the dawn of time.

Those of us in the arts tend to be especially in tune with the concept of patronage. Our forefathers such as Beethoven and Bach thrived upon such support and although terminology has evolved since their time, most artists would agree that it is a healthy combination of donors, grants, sponsors, and our regular concert going patrons who collectively produce our living.

Finding the correct way to properly thank a donor is about as easy as sneaking an elephant out of a circus tent! I recall inquiring once with a very special person, one who without his support so much of what both The Jazz Loft and my career has become would not have been possible, why he didn’t come to more events. He responded, “Do you really want to know why I don’t come to anything?” To which I replied, “Yes, I do!” To this he quickly quipped, “Because every time I show up you thank me!”

Over the years I’ve found joy in getting to know every individual that supports The Jazz Loft. I’ve truly enjoyed figuring out and discovering who finds appreciation in a letter, who welcomes a phone call, or who enjoys an annual summer lunch get together for a lobster sandwich and a beer. It’s actually one of my favorite parts of running a not-for-profit — getting to know amazing people, building real and genuine relationships, and forging what I know will be some lifetime friendships.

I was inspired to write this op-ed out of the desire to find a way to capture in words the gratitude I feel towards the philanthropists among us. Our community was literally designed and built by a philanthropist, Ward Melville. When I think of the names of those who have continued that bold tradition of giving and support, I resist sharing specific names, but suffice it to say you all know who they are even if you don’t know them personally. 

Chances are you bought your house from them, or perhaps they’ve managed your retirement through the years. You might get your morning coffee from them or chat with them when you’re picking up your kid from school. They might volunteer or help run one of our many outstanding museums, art galleries, community institutions or preservation organizations. Maybe they fixed your car recently or you’ve bumped into them about town, at an outdoor concert, or in your favorite park. They’re quite often invisible, or as we say in Jazz, “tippin’ on the QT.”

What I do know is that no matter how little or how much in the spotlight or foreground they choose to be, these individuals are an incredible part of the fabric of who we are as a community. They are an invaluable resource, beyond definition, and without question an incredible gift to us all. 

I consider it an honor and a privilege to serve our community in the positions and places I’ve been blessed to be and I’m inspired by those who are the philanthropists among us. To all of you out there, and you know who you are, THANK YOU!

Author Thomas Manuel, DMA is a Jazz historian, Artist in Residence at Stony Brook University, trumpet player and President and Founder of The Jazz Loft, 275 Christian Ave., Stony Brook. For more information, visit www.thejazzloft.org.

Matt LoNigro

By Fr. Francis Pizzarelli

Father Frank Pizzarelli

On Wednesday, May 10, 2023, in the early afternoon, a local icon died of a massive heart attack at the age of 51; his wife found him sitting in his office chair. A local EMS worker who lives down the street came running and tried to revive him. He had already passed; I arrived just after he was pronounced.

Matthew “Matt” LoNigro left his lovely wife Julia, a local tenured schoolteacher and two extraordinary children: Matthew Jr., 20, and Abigail, a 16-year-old student at Miller Place High School. Matt was very actively involved in the Miller Place school district as the dynamic director of the Miller Place Boys Lacrosse.

Lacrosse was one of his many passions. For many years, he was actively involved on the Board of Directors for Suffolk County PAL Lacrosse. During his early career, he was actively involved with Port Jefferson Sporting Goods, a family business. He was a salesman for school districts seeking sports equipment and sports uniforms. He was such a dynamic salesman; he probably could’ve sold the Pope the Brooklyn Bridge.

Matt spent most of his adult life doing for others. He was actively involved with Christmas Magic, Backpack Pirates and countless other activities that reached out to the disadvantaged in our larger community. If somebody was in trouble and needed good advice and/or a helping hand, Matthew was the go-to guy. He was a tremendous mentor for young athletes who wanted to be lacrosse players.

We have lost a powerful example of what community and reaching out to others is really supposed to be about. These are crazy times. We need more people with Matt’s passion and commitment to helping others, with the purpose of giving back. His heart and random acts of kindness were the hallmark of his life.

I first met Matt when he was in middle school. As most know, he was part of a very large loving family. It was his family that taught him how to love and to be of service to others. Like many young men in their 20s, Matt struggled. He spent time living with me at Hope House. Even during those struggling days battling conflict, he was a power of example for the men he lived with.

When Matt completed our program, he started giving back and has not stopped for more than 20 years. Before he passed, he would come by every week to encourage the men in our community; especially those who were struggling to stay the course. His power of example that life can be better and one can change inspired so many over the years to take the risk to embrace change and transformation. 

There was not a week since Matt lived with our community that I have not received a text or visit always making sure he ended both with “thank you for saving my life!” The world is a better place because Matt LoNigro walked among us. His power of example and his profound gratitude will live on to inspire so many others to embrace the process of change and transformation and to realize that they too can make the world a better place. 

Father Francis Pizzarelli, SMM, LCSW-R, ACSW, DCSW, is the director of Hope House Ministries in Port Jefferson.

METRO photo

By Leah S. Dunaief

Leah Dunaief

This past weekend was both fabulous and exhausting. We drove nine hours down to Virginia to celebrate with my granddaughter as she graduated from college, and with my son and daughter-in-law, her parents, who helped make it happen. Both sides of the family were represented, and we were all in, cheering, laughing, eating, strolling and talking, talking, talking for two days straight, not counting our travel days.

We were certainly not alone enjoying this milestone. I never saw so much traffic on the roads between here and Virginia, both going and coming, and we theorized it was all those families and all those graduates driving the highways on this college graduation weekend in May.

The joy of a graduation from college spans generations. Those who seemed to feel the accomplishment most, perhaps, were the families of first-generation graduates, whose members would often boast to anyone listening, “She’s the first to graduate.” We all cheered, clapped, and if we could, whistled during those 30 seconds when our loved one crossed the stage, was handed the diploma, smiled for the camera, then returned to his or her seat.

Predictably, we heard lots of speeches. Those who received honorary doctorates, the president of the college, the chancellor, the student representative, the keynote speaker, all addressed the graduating class and their guests with words of wisdom that, as I recall from my graduation, were promptly ignored. For us then, the tone, however, was hopeful and positive.

This time, though, there were two differences that I heard. The first was a recognition that the world for these young people had changed, both physically and societally. The country was sadly divided, and climate change was altering the globe. People were not listening to each other. That they might enjoy better lives than their parents because their future was bright was never mentioned.  

These graduates had their lives and their studies interrupted by the pandemic and were captive of their computers for part of their  learning. The message was that they had lost out in their four years, lost the easy camaraderie of uninterrupted campus life and the person-to-person contact with their classmates and professors. There was some reference to overcoming challenges and resilience, but on the whole, there was none of the usual comments as to how this next generation was going to make the world a better place. It seemed the goal was just to cope.

The other difference from the educators was, to me, defensive. Stressed was the need and importance of education. Of course, they were preaching to the choir. But still, the comment rang out, “When you have forgotten all [the facts] that you have learned, what you will have left is education.” More than once, the reference was to having learned how to think analytically as being the major benefit of their college years.

I did get a kick out of one dean, who referred in her talk to the various world events that had occurred during the past four years. We listened attentively because we all experienced them. And when she was concluding, she confessed that almost the whole speech had been written by ChatGPT. We laughed but not without a tinge of concern for future college students.

As always, at graduations, it is a happy and also a sad time for the graduates. There is a lot of “goodbye.” They are leaving behind those they had come to know and places that had become as familiar to them as their dorm rooms: where they shopped for food, where they retreated to study, where they played volleyball, where they enjoyed their “midnight snacks” that were probably well beyond midnight.

Our granddaughter keenly felt the yin and yang of moving on. She tried to spend time with us even as she was drawn to the gatherings and parties on campus of her friends and roommates. I wanted to tell her that this time was a beginning, more than an end, and that she would be taking the best with her into the next chapter. 

But I didn’t. She had already heard enough speeches.

Linx. Photo from Smithtown Animal Shelter

MEET LINX!

This week’s shelter pet is Linx, a four year-old Male German Shepherd who was taken in to the Smithtown Animal Shelter as a stray and never claimed. He is highly intelligent, well-mannered and is always in the mood to play fetch! He requires a very active home that will meet his mental and physical stimulation needs. Linx is a good-natured dog that needs a strong owner who will provide him with some structure and companionship. Linx should only be adopted into a pet-free and child-free home with an experienced German Shepherd owner that will respect his personal space.

If you are interested in meeting Linx, please call the shelter to schedule time to properly interact with him in a domestic setting, which includes a Meet and Greet Room, the dog runs, and a Dog Walk trail.

The Smithtown Animal & Adoption Shelter is located at 410 Middle Country Road, Smithtown. Visitor hours are currently Monday to Saturday from 10 a.m. to 3 p.m. (Sundays and Wednesday evenings by appointment only). For  more information, call 631-360-7575 or visit www.townofsmithtownanimalshelter.com.

By John L. Turner

John Turner

It’s a warm Spring day and I’m relaxing on a bench on the edge of Swezey’s Pond within Cranberry Bog County Nature Preserve. Situated in western Southampton Town, about three quarters of a mile south of the Riverhead traffic circle, the preserve contains the remains of one of the larger commercial cranberry bogs that once prospered on Long Island.

The light is bright and the warmth most inviting, both for me and the eight painted turtles of various sizes that have scrambled up on two nearby logs. At first the water appears to be still but looking a little more closely I can see a current moving from right to left or from south to north. This water drains from Wildwood Lake about a mile to the south providing the base flow to the Little River, one of the four tributaries to the Peconic River. 

At the far end of the pond a ghost white American Egret stalks the shallows and to its right, much closer to me, I hear the “phoe-be” call of a spring migrant Eastern Phoebe flitting around the spindly-spiraled top of an Atlantic White Cedar.    

I am in the middle of the Pine Barrens, the largest intact forest remaining on Long Island, protected by state law after a long and intense legal battle that Newsday called the “War in the Woods.” It was a battle well worth fighting as the protection of the tens of thousands of contiguous pine-clad acres adds immeasurably to the quality of life of Long Islanders. 

From a pragmatic point of view the Pine Barrens sits over the largest and cleanest groundwater supplies on Long Island with an estimated five trillion gallons of water contained in the saturated sands beneath the barrens. Also, the Pine Barrens is ecologically significant as it provides habitat to many hundreds  of species of plants and animals, some with novel adaptations that enable them to survive wildfire and other harsh conditions of the ecosystem. 

And like Manhattan’s Central Park, a destination for  countless visitors and city dwellers, the Pine Barrens, Long Island’s Central Park, will, through time, become the same. Already used by many Long Islanders to hike, camp, bird, and canoe, the Pine Barrens will undoubtedly  be visited by many more as it becomes better known.   

Pitch Pine is the dominant plant of the Pine Barrens and provides half of the epithet — the Pine Barrens (the other half relates to the sandy, porous, and nutrient-poor soils that underlie the area). In many places, typically areas that have burned more frequently,  it is the only tree found; in other areas of the Pine Barrens it shares the canopy with various oak species such as scarlet, white, and black oak. 

Beneath the canopy, in the shrub layer, two dwarf oaks — bear oak and dwarf chestnut oak — form extensive thickets. These oaks are genetically dwarfed and even if their acorns are planted in soils rich in nutrients, the species will never obtain the height of our native tree oaks. Intermingled in these shrubby thickets are the heath species, such as black huckleberry, and early and late lowbush blueberries. On the forest floor where there’s ample sunlight you can find both common and striped wintergreen and the beautiful trailing arbutus. 

In the wetlands a host of other plant species abound — water lilies in the open water of ponds and lakes to a number of rare plants growing in the shallow water near shorelines and along the sandy shorelines themselves — including several carnivorous plant species as bladderworts and sundews. Highbush blueberry rings many wetlands and fills small bogs. These wetlands provide habitat to  turtles, frogs, toads, and salamanders while ovenbirds, scarlet tanagers, whip-poor-wills, pine warblers, and may other songbirds fill the forests and wetlands with song.  

Fire has long played a dominating role in shaping the character of these pine dominated forests, having swept through the barrens for thousands of years. Many of the plants and animals have adapted to fire with pitch pine having thick bark; in the unique and globally rare dwarf pine plains the dwarf pines depend upon fire to open their cones which remain resolutely closed in fire’s absence.   

It’s no accident that nearly one hundred square miles of the Pine Barrens has been permanently preserved. Were it not for the direct and intensive intervention of the Long Island Pine Barrens Society, both in the courts and in the court of public opinion, the Pine Barrens would, no doubt, have succumbed to development. But in a classic David (the Society, other conservation organizations) vs. Goliath (municipalities and wealthy, well-heeled developers) contest, the environmental community won with the passage of the 1993 Pine Barrens Protection Act that established the 105,000 acre Central Pine Barrens including the 55,000 acre Core Preservation Area in which development is not allowed.  

All Long Islanders will long be the beneficiaries of the Pine Barrens being preserved and this preservation effort has a unique aspect to it: it ensures in a bi-county region, cheek-to-jowl with one housing subdivision after another, surrounding industrial parks, strip shopping centers and large malls, where 2.7 million Long Islanders work, live, and play, there will always be wildness available — a wild character where if you’re positioned in the hollow of the morainal hills in Manorville you will hear no human sounds, where at night the pin prick light of stars shine amidst the inky blackness and from which the rhythmic calls of the whip-poor-will or deep hoots of the great horned owl can still be heard. It is a landscape where, in so many places you can hike on meandering trails for many miles and see no one, or evidence of anyone save the footprints of fellow hikers seeking the same solitude. 

A resident of Setauket, John Turner is conservation chair of the Four Harbors Audubon Society, author of “Exploring the Other Island: A Seasonal Nature Guide to Long Island” and president of Alula Birding & Natural History Tours.

METRO photo
Chest pain is only one of many possible symptoms.

By David Dunaief, M.D.

Dr. David Dunaief

Each year, 805,000 people in the U.S. have heart attacks, or myocardial infarctions —about one every 40 seconds (1). These statistics traverse race and gender lines, even though symptoms may be experienced differently. Outcomes for those having a heart attack are significantly better if they receive immediate medical attention. First, however, you need to recognize the symptoms.

What are symptoms of a heart attack?

The most recognizable symptom is chest pain. However, there are a number of other, more subtle, symptoms such as discomfort or pain in the jaw, neck, back, arms and epigastric, or upper abdominal areas. Others include nausea, shortness of breath, sweating, light-headedness and tachycardia (racing heart rate).

Unfortunately, less than one-third of people know these symptoms (2). About 10 percent of patients present with atypical symptoms — without chest pain — according to one study (3).

It is not only difficult for the patient but also for the medical community, especially the emergency room, to determine who is having a heart attack. Fortunately, approximately 80 to 85 percent of chest pain sufferers are not having a heart attack. More likely, they have indigestion, reflux or other non-life-threatening ailments. However, don’t hesitate to seek immediate medical attention; it’s better to have a medical professional rule out a heart attack than to ignore one.

Are heart attack symptoms different for men and women?

There has been much discussion about whether men and women have different symptoms when it comes to heart attacks. Several studies speak to this topic.

There is data showing that, although men have heart attacks more commonly, women are more likely to die from a heart attack (4). In a Swedish study, after having a heart attack, a significantly greater number of women died in the hospital or near-term when compared to men. The women received reperfusion therapy, artery opening treatment that consisted of medications or invasive procedures, less often than the men.

However, recurrent heart attacks occurred at the same rate, regardless of sex. Both men and women had similar findings on an electrocardiogram. This was a study involving approximately 54,000 heart attack patients, with one-third being women.

One theory about why women receive less aggressive treatment when first presenting in the ER is that they have different and more subtle symptoms — even chest pain symptoms may be different. But, is this true? Not according to several studies.

In one observational study of 2,500 patients with chest pain, results showed that, though there were some subtle differences, when men and women presented with this main symptom, it was of a similar nature (5). There were 34 chest pain characteristic questions used to determine if a difference existed. These included location, quality or type of pain and duration. Of these, there was some small amount of divergence: the duration was shorter for a man (2 to 30 minutes), and pain subsided more for men than for women. The authors concluded that determination of heart attacks with chest pain symptoms should not factor in the sex of patients.

This trial involved an older population; patients were a median age of 70 for women and 59 for men, with more men having had a prior heart attack. The population difference was a conspicuous weakness of an otherwise solid study, since age and previous heart attack history are important factors.

In the GENESIS-PRAXY study, another observational study, the median age of both men and women was 49. Results showed that chest pain remained the most prevalent presenting symptom in both men and women (6). However, of the patients who presented without distinct chest pain and with less specific EKG findings, significantly more were women than men.

Those who did not have chest pain symptoms may have experienced back discomfort, weakness, discomfort or pain in the throat, neck, right arm and/or shoulder, flushing, nausea, vomiting and headache. If the patients did not have chest pain, regardless of sex, the symptoms were diffuse and nonspecific. 

Some studies imply that as much as 35 percent of patients do not present with chest pain as their primary complaint (7).

What should you do if someone is having a heart attack?

Call 911 immediately, and have the patient chew an adult aspirin (325 mg) or four baby aspirins, provided they do not have a condition that precludes taking aspirin. The purpose of aspirin is to thin the blood quickly, but not if the person might have a ruptured blood vessel. The 911 operator or emergency medical technician who responds can help you determine whether aspirin is appropriate.

What are the most frequently occurring heart attack symptoms to watch for?

Most patients have chest pain, and both men and women have similar types of chest pain. However, this is where the simplicity stops and the complexity begins. The percentage of patients who present without chest pain seems to vary significantly depending on which study you review — ranging from less than 10 percent to 35 percent.

Non-chest pain heart attacks have a bevy of diffuse symptoms, including obscure pain, nausea, shortness of breath and light-headedness. This is seen in both men and women, although it occurs more often in women. It’s important to recognize heart attack symptoms, since quick action can save your life or that of a loved one.

References:

(1) Circulation. 2022;145(8):e153–e639. (2) MMWR. 2008;57:175–179. (3) Chest. 2004;126:461-469. (4) Int J Cardiol. 2013;168:1041-1047. (5) JAMA Intern Med. 2014 Feb. 1;174:241-249. (6) JAMA Intern Med. 2013;173:1863-1871. (7) JAMA. 2012;307:813-822.

Dr. David Dunaief is a speaker, author and local lifestyle medicine physician focusing on the integration of medicine, nutrition, fitness and stress management. For further information, visit www.medicalcompassmd.com or consult your personal physician.

The Port Jefferson Power Station. Photo by Raymond Janis

The Environmental Protection Agency’s new regulations concerning power plants could have dramatic consequences for communities across the North Shore.

The EPA is proposing emissions caps and further guidelines for fossil-fuel-burning power plants. 

The proposed guidelines aim to “set limits for new gas-fired combustion turbines, existing coal, oil and gas-fired steam generating units, and certain existing gas-fired combustion turbines,” according to an EPA statement.

While we certainly acknowledge the need for government to intervene in the spread of planet-warming carbon, we expect these regulations to have severe consequences for our local communities.

Generations ago, residents of Port Jefferson and Northport planned their communities around these power plant facilities. Power plants have represented a lucrative tax base for these communities, subsidizing several important community ends.

In exchange for the industrial activities taking place at these plants, residents saw opportunities — opportunities for better schools, better services and a better way of life. Now these opportunities may remain only aspirational.

Local governments and school districts are already struggling as it is. Between inflation and rising costs, further declines in public revenue will only compound the financial troubles of our public institutions. Yet, despite the challenges ahead, plans must start moving now.

At the local level, municipalities and school districts that rely upon LIPA subsidies should begin imagining a future in which those subsidies no longer exist. If plants start shuttering, public officials will be tasked with plugging enormous holes in their budgets. What are their plans to do that?

We are seeing warming temperatures and the changing climate affecting a wide array of local issues. From coastal erosion to prolonged droughts to intensifying flooding and countless other concerns, this global environmental phenomenon is already reshaping our local policies — and soon our bottom line.

Using fossil-fuel-powered plants to subsidize our way of life has become increasingly untenable. Municipal and school district officials may soon face some extremely uncomfortable discretionary choices.

For this reason, it is time for our leaders to adopt a policy of radical acceptance and realism. Relocating waterfront properties inland, conserving our scarce water supply and protecting open spaces are some ways to meet this moment. But the necessary conversations about taxes and budgets need to happen as well.

With a new frame of mind, we can rise to the challenges ahead. We can adapt our communities to the changing environment. 

With a clear focus and sober long-term thinking, let us cease denying the transformations happening before our eyes. Instead let us plan to deal with them.

John Moses. Photo courtesy of CSHL

By Daniel Dunaief

It sounds like something straight out of a superhero origin story.

With resistance to widely used drugs becoming increasingly prevalent among bacteria, researchers and doctors are searching for alternatives to stem the tide.

That’s where shape shifting molecules may help. Cold Spring Harbor Laboratory Professor of Organic and Click Chemistry John Moses and his team have attached the drug vancomycin to a molecule called bullvalene, whose atoms readily change position and configuration through a process called a thermal sigmatropic rearrangement as atoms of carbon break and reform with other carbon atoms.

The combination of the bullvalene and vancomycin proved more effective than vancomycin alone in wax moth larva infected with vancomycin resistant Enteroccoccus bacteria.

“Can I make a molecule that changes shape and will it affect bacteria? That was the question,” Moses said. The promising early answer was, yes!

Moses believes that when the bullvalene core is connected to other groups like vancomycin, the relative positions of the drug units change, which likely change properties related to binding.

The urgency for novel approaches such as this is high, as drug resistant bacteria and fungi infect about 2.8 million people in the United States per year, killing about 35,000 of them. 

In his own life, Moses said his father almost died from a bacterial infection five years ago. Vancomycin saved his father’s life, although the infection became resistant to the treatment. Other drugs, however, conquered the resistant strain.

“We need to work hard and develop new antibiotics, because, without them, there will be a lot more misery and suffering,” Moses explained.

To be sure, an approach like this that shows promise at this early stage with an insect may not make the long journey from a great idea to a new treatment, as problems such as dosage, off target effects, toxicity, and numerous other challenges might prevent such a treatment from becoming an effective remedy.

Still, Moses believes this approach, which involves the use of click chemistry to build molecules the way a child puts together LEGO blocks, can offer promising alternatives that researchers can develop and test out on a short time scale.

“We shouldn’t be restricted with one set of ideas,” Moses said. “We should keep testing hypotheses, whether they are crazy or whatever. We’ve got to find alternative pathways. We’re complementary” to the standard approach pharmaceutical companies and researchers take in drug discovery.

Looking to history, Moses explained that the founders of the Royal Society in 1660 followed the motto “nullius in verba,” or take nobody’s word for it. He believes that’s still good advice in the 21st century.

The shape shifting star

Moses has described this bullvalene as a Rubik’s Cube, with the parts moving around and confounding the bacteria and making the drug more effective.

The CSHL scientist and his team don’t know exactly why shape shifting makes the drug work in this moth model.

He speculated that the combination of two vancomycin units on either side of a bullvalene center is punching holes in the cell wall of the bacteria.

Moses is eager to try to build on these encouraging early developments. “If you can make it, then you can test it,” he said. “The sooner the better, in my opinion.”

Moses acknowledged that researchers down the road could evaluate how toxic this treatment might be for humans. It didn’t appear toxic for the wax moth larvae.

Welcoming back a familiar face

Adam Moorhouse
Photo by Rebecca Koelln

In other developments in his lab, Moses recently welcomed Adam Moorhouse back to his team. Moorhouse, who serves as Chemistry Data Analyst, conducted his PhD research in Moses’s lab at the University of Oxford.

Moorhouse graduated in 2008 and went on to work in numerous fields, including as an editor for the pharmaceuticals business and for his own sales consultancy. In 2020, he had a motorcycle accident (which he said was his fault) in which he broke 16 bones and was hospitalized for a while. During his recovery, he couldn’t walk.

At the time, he was working in the intense world of sales. After the accident, Moorhouse decided to build off his volunteer work with disabled children and become a high school teacher. After about 18 months of teaching, Moorhouse reconnected with Moses.

“It’s nice getting here and thinking about chemistry and thinking about ideas and communicating those ideas,” Moorhouse said.

He has hit the ground running, contributing to grants and helping to translate intellectual property into commercial ventures.

The chance to work on projects that get molecules into humans in the clinic was “really exciting,” Moorhouse said. “I’m back to try and support that.”

Moorhouse will be working to procure funding and to build out the business side of Moses’s research efforts.

“Where I’d like to lend a hand is in driving ongoing business discussions,” Moorhouse said. He wants to “get these small molecules into the clinic so we can see if they can actually treat disease in humans.” The vehicle for that effort eventually could involve creating a commercial enterprise.

Like Moses, Moorhouse is inspired and encouraged by the opportunity for small operations like the lab to complement big pharmaceutical companies in the search for treatments.

Moses believes the work his lab has conducted has reached the stage where it’s fundable. “We’ve done something that says, ‘we checked the box,’” he said. “Let’s find out more.”

Currently living on campus at CSHL, Moorhouse appreciates the opportunity to do some bird watching on Long Island, where some of his favorites include woodpeckers, herons, egrets, robins and mockingbirds.

He is tempted to get back on a motorcycle and to return to mountain biking.

As for his work, Moorhouse is excited to be a part of Moses’s lab.

“Back in my PhD days, [Moses] was always an idea machine,” Moorhouse said. “The aim is to move ideas to the clinic.”

 

METRO photo
A Column Promoting a More Earth-friendly Lifestyle

By John L. Turner

John Turner

There’s an expression in lawn care “Cut it high and let it lie.” Leaving grass on the longer side is healthier for the grass as it dries out more slowly and there’s more grass blade to produce food as it photosynthesizes. And letting it lie is good for both your lawn and the planet. The clippings quickly break down, returning nutrients back to the grass and soil and the clippings do not, contrary to popular belief, add thatch to your lawn. 

The second best option is to compost grass clippings with other yard waste and to apply the compost to your lawn and flower beds once it’s ready. 

The worst option, which so many homeowners choose, is to bag the clippings and leave curbside for the town to pick up (or worse yet, dump it in a neighboring preserve or parkland). This waste is harder to recycle, inefficient to burn, and costs the town more to manage. So, for the sake of a healthier lawn and planet, let those grass clippings lie.      

A resident of Setauket, John Turner is conservation chair of the Four Harbors Audubon Society, author of “Exploring the Other Island: A Seasonal Nature Guide to Long Island” and president of Alula Birding & Natural History Tours.