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Jim and Jacqueline Olsen

By Daniel Dunaief

When Jacqueline Olsen learned the day before her birthday last November that she needed surgery for lung cancer, she felt anxious about a procedure she knew could be painful and could involve a lengthy recovery.

“It’s not only my birthday, it’s Thanksgiving,” said Olsen, who is a resident of St. James and is an agent for personal insurance such as home, auto and umbrella insurance. “Everybody was real tense. It was not a pleasant holiday.”

Olsen’s father, William Leonard, and father-in-law, James Olsen, had died of lung cancer after having open chest surgeries. The pain of what her father went through 48 years ago and father-in-law over 20 years ago was fresh in her mind as she readied herself for her own procedure.

Dr. Ankit Dhamija

Speaking with doctors at Stony Brook University Hospital, Olsen heard about newer, better options.

Dr. Ankit Dhamija, Cardiothoracic Surgeon and Director of Thoracic Robotic Surgery at Stony Brook Medicine, suggested to Olsen that she was a candidate for a robot-assist surgery called the da Vinci Surgical System. 

Olsen and her family gathered considerable information about the procedure.

“I did some research on it and it said it would be a faster recovery and I would be up and back to my normal self pretty soon afterward,” said Olsen. “It seemed like a less invasive surgery.”

The robotic surgery does not involve turning over the procedure to a machine, Dr. Dhamija explained.

Instead, the process involves making considerably smaller incisions and guiding the robot through the body to remove the cancerous tissue.

“The robot is a machine that is an extension of our hands,” said Dr. Dhamija, who has performed about 500 such procedures with the help of a robot, including around 70 since he arrived at Stony Brook.

The robotic system allows surgeons like Dr. Dhamija and Dr. Henry Tannous, Cardiothoracic Surgeon and Chief of the Cardiothoracic Surgery Division at Stony Brook Medicine, among others, to sit in the operating room with the patient while the robot enters through an incision. The robot provides a three dimensional view of the inside of the body, magnifying cells by ten times.

The robot assist can also improve the ability of surgeons to perform fine operations.

The system “does have a machine algorithm associated with it that actually is known to reduce tremors in surgeons that have tremors,” said Dr. Dhamija. “Someone that may not be able to do a certain portion of the operation due to their technical limitations can subsequently do it with the robot.”

Dr. Henry Tannous

In the procedure, the surgeon can see and maneuver through the body effectively, searching for the specific cells to remove.

An interventional radiologist can inject a dye which under CT guidance allows the surgeon to “see where the lesion is and to verify that you have adequate margins” or the border between cancerous and non-cancerous cells, Dr. Dhamija said. “Having the dye in there to identify [the cancer] is helpful,” he added.

By using the robot instead of creating a large incision, doctors can reduce the time patients spend in a hospital down to as little as one to three days from the four to eight days after an open chest lobectomy.

“There’s so much to be said about someone [recovering] in their own home,” said Dr. Dhamija. They “get to sleep properly, their bowel habits are more normal, and they get to reengage in their daily life functions sooner. I’m a big proponent of a patient taking charge of their own postoperative care.”

Indeed, Stony Brook doctors have become so confident and comfortable with the robot assist that it has become the main platform for thoracic oncology patients at Stony Brook Medicine, explained Dr. Tannous. Tannous estimates that 90 percent of the lobectomies will be performed robotically in 2022, up from 10 to 20 percent in 2021.

In an email, Dr. Tannous wrote that other specialties that have adopted the robotic platform include gynecology, urology, colorectal, bariatrics, and general surgery.

Stony Brook is also expanding robotic surgery to include cardiac procedures in 2023.

Dr. Tannous said robotic procedures that cut down on recovery time means less risk of hospital-acquired infections, lower extremities blood clots, and numerous other benefits.

Some day, theoretically, the robot may enable remote procedures, with surgeons operating the robot with the help of an on-site local medical team. That could be helpful for astronauts who develop a medical problem far from home where they need emergency surgery.

An important caveat with that, Dr. Dhamija said, is that the staff on site would need to be able to complete a procedure if an open chest surgery became necessary.

Olsen, who was out of the hospital less than 24 hours after she had surgery in late May, has become a fan of the technology and of the team at Stony Brook.

Olsen, who has three scars on her back and two on her side, felt pain for about a week. As she recovered, she never felt the need to fill a prescription for a stronger painkiller, choosing to treat the pain with Motrin. She plans to continue to take blood tests every three months and to get CAT scans every six months.

Olsen was thrilled with the quality of care she received and is pleased she can look forward to sharing quality summer time during the family’s annual beach trip. “It’s heaven to me,” she said, where she can “spoil my grandchildren.

As for a perspective on her surgery, she said the difference between 20 years ago and now is “unbelievable. It was such an awful experience” for her father and father in law. “This was a million times better.”

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File photo
By Bruce Miller

The Metropolitan Transportation Authority is receiving $10 billion for infrastructure improvements from the federal government, and we along the Port Jefferson line need a small part of this money for better services.

Bruce Miller, above. File photo from the Port Jefferson village website

As a former Port Jeff Village trustee, I spoke with the former Long Island Rail Road president, Phil Eng, and the LIRR executive planning and technical staff about this issue. They presented plans of their own: double tracking, bridge expansion and reconstruction, electrification and the possibility of battery-powered trains.

My sense of all of this: The LIRR plans are so grandiose and unrealistic that there were no plans at all, just a convenient excuse to do nothing. Rather than bells and whistles, we need a simple upgrade to some form of electric service.

Commuters all along the North Shore are taking the Ronkonkoma line. Some residents even drive to Huntington or Hicksville for decent transit.

Due to inadequate services, our local commuters sit in 10 to 20 miles of unnecessary traffic to get to an electric rail. The pollution generated along the Port Jeff line from diesel requires us to either transfer — often in inclement weather — or “commute to the commute.” This is unacceptable and very ungreen.

LIRR’s logic is to deprive the North Shore of commuters and then argue against electrification due to insufficient ridership. Because of this, we are among the farthest commuters away from New York City, paying among the highest fares, with the shabbiest service.

For decades, LIRR has demonstrated a profound disregard for our local communities. Most travelers islandwide have had electrical service for a generation … or three! The fact that we haven’t joined them should say a lot about LIRR’s priorities and its feelings for its North Shore travelers.

New York State Assemblyman Steve Englebright (D-Setauket) and Suffolk County Legislator Kara Hahn (D-Setauket) have advocated for moving the Port Jefferson train station west to the 120-acre Lawrence Aviation property.

The Village of Port Jefferson needs to engage with Englebright and Hahn to negotiate an adequate tract of land with the LIRR west of Routes 25A and 112. The advantage of this is great.

It would eliminate the Main Street grade crossing and its resultant traffic. It would free up rail yards east of the existing station for a swap of land and subsequent incorporation into Port Jefferson Village. In addition, the freeing up of the existing station property could be used for parkland and recreation.

This is urgent. Decisions on that $10 billion windfall are being made now. The opportunity to electrify the line will not come for another generation. 

Bruce Miller served as Port Jefferson Village trustee from 2014-2022.

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Katia Lamer during her experiment in Houston. Photo courtesy of U.S. Department of Energy Atmospheric Radiation Measurement user facility

By Daniel Dunaief

Clouds and rain often cause people to cancel their plans and seek alternative activities.

The opposite was the case for Katia Lamer this summer. A scientist and Director of Operations of Brookhaven National Laboratory’s Center for Multiscale Applied Sensing, Lamer was in Houston to participate in ESCAPE and TRACER studies to understand the impact of pollution on deep convective cloud formation. 

Katia Lamer during her experiment in Houston. Photo courtesy of U.S. Department of Energy Atmospheric Radiation Measurement user facility

With uncharacteristically dry weather and fewer of the clouds she and others intended to study, she had some down time and created a plan to study the distribution of urban heat. “I am always looking for an opportunity to grow the Center for Multiscale Applied Sensing and try to make the best of every situation,” she said.

Indeed, Lamer and her team launched 32 small, helium-filled party balloons. She and Stony Brook University student Zachary Mages each released 16 balloons every 100 meters while walking a one mile transect from the suburbs to downtown Houston. A mobile observatory followed the balloons and gathered data in real time through a radio link. 

While helium-filled party balloons are not the best option, Lamer said the greater good lay in gathering the kind of data that will be helpful in measuring and monitoring climate change and explained that until some better balloon technology was available, this is what they had to use.

“Typically, we launch the giant radiosonde balloons, but you can’t launch them in a city,” she said because of the lack of space for these larger balloons to rise without hitting obstacles. The balloons also might pass through navigable airspace, disturbing flight traffic.

The smaller party balloons carried sensitive equipment that measured temperature and humidity and had a GPS sensor tucked into foam cups.

“If we can demonstrate that there is significant variability in the vertical distribution of temperature and humidity at those scales, then this would suggest that we should push to increase the resolution of our models to improve climate change projections,” she explained.

By following these balloons closely with a mobile observatory, Lamer and her team can avoid interference from other signals and signal blockage by buildings.

The system they used allowed them to select a cut-off height. Once the balloons reached that altitude, the string that connected the sensors to the balloon burns off and the sensors start free-falling while the balloon climbs until it pops.

The sensors collect continuous data on temperature, humidity and horizontal wind during the ascent and descent. Using the GPS, researchers can collect the sensors.

While researchers have studied urban heat using mesoscale models and satellite data, that analysis does not have the spatial resolution to understand community scale variability. Urban winds also remain understudied, particularly the winds above the surface, she explained.

Winds transport pollutants, harmful contaminants, and heat, which may be relieved on some streets and trapped on others.

Michael Jensen, principal investigator for the Tracking Aerosol Convection interaction Experiment, or TRACER and meteorologist at BNL, explained that Lamer is “focused on what’s going on in the urban centers.” Having a truck that can move around and collect data makes the kind of experiment Lamer is conducting possible. Jensen described what Lamer and her colleagues are doing as “unique.”

New York model 

Katia Lamer during her experiment in Houston. Photo courtesy of U.S. Department of Energy Atmospheric Radiation Measurement user facility

Lamer had conducted similar experiments in New York to measure winds. The CMAS mobile observatory’s first experiment took place in Manhattan around the One Vanderbilt skyscraper, which is 1,400 feet high and is next to Grand Central Terminal. No balloons were launched as part of that first experiment.She launched the small radiosonde balloons for the first time this summer in Houston around the 990 foot tall Wells Fargo complex. 

Of the 32 balloons she and Mages launched, they collected data from 24. The group lost connection to some of the balloons, while interference and signal blockage disrupted the data flow from others.

Lamer plans to use the information to explore how green spaces such as parks and blue infrastructure including fountains have the potential to provide some comfort to people in the immediate area.

Such observations will provide additional insight beyond numerical models into how large an area a park can cool in the context of the configuration of a neighborhood.

This kind of urban work can have numerous applications.

Lamer suggested it could play a role in urban planning and in national security, as officials need to know the dispersement of pollutants and chemicals. Understanding wind patterns on a fine scale can help inform models that indicate areas that might be affected by an accidental release of chemicals or a deliberate attack against residents.

Bigger picture

Katia Lamer during her experiment in Houston. Photo by Steven Andrade/ BNL

Lamer is gathering data from cities to understand the scale of heterogeneity in properties such as heat and humidity, among others. If conditions are horizontally and vertically homogeneous, only a few permanent stations would be necessary to monitor the city. If conditions are much more varied, more measurement stations would be necessary.

One way to perform this assessment is to use mobile observatories that collect data. The ones Lamer has deployed use low-cost, research-grade instruments for street level and column wide observations.

Over the ensuing decades, Lamer expects that the specific conditions will likely change. Collecting and analyzing data now will enable scientists to develop a baseline awareness of typical urban conditions.

Scientific origins

A native of St.-Dominique, a small farmer’s village in Quebec Canada, Lamer was impressed by storms as she was growing up. She would often watch them outside her window, fascinated by what she was witnessing. After watching the Helen Hunt and Bill Paxton movie Twister, she wanted to invent her own version of the Dorothy instrument and start chasing storms.

When she spoke with her high school guidance counselor about her interest in tornadoes, which do not occur in Quebec, the counselor said she was the first person to express such a professional passion and had no idea how to advise her.

Lamer, who grew up speaking French, attended McGill University in Montreal, where she studied earth system science, aspects of geology and geography and a range of earth-related topics.

Instead of studying or tracking tornadoes, she has worked on cloud physics and cloud dynamics. Hearing about how clouds are the biggest wild card in climate change projections, she decided to embrace the challenge.

During her three years at BNL, Lamer, who lives with her husband and children in Stony Brook, has appreciated the chance to “push the envelope and be creative,” she said. “I really hope to stay in the field of urban meteorology.”

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Stony Brook Breast Cancer Screening mobile truck. (8/24/18)

By Daniel Dunaief

Some groups of people on Long Island have a much higher incidence of a particular type of cancer than others.

On an age adjusted rate, African American men, for example, were almost twice as likely to develop prostate cancer from 2014 to 2018 as Caucasians. Out of 100,000 African American men, 216.6 had prostate cancer compared with 123.9 out of 100,000 white men, according to data from the National Cancer Institute.

Dr. Linda Mermelstein. Photo from Stony Brook Medicine

Dr. Linda Mermelstein, Associate Director of Stony Brook Cancer Center’s Office for Community Outreach and Engagement, is working with her team to address those stark differences and to empower members of the community to protect their health and make informed decisions.

“A lot of our focus is on addressing disparities” in cancer care in various communities throughout Long Island, Dr. Mermelstein said. 

The Cancer Center Outreach and Engagement office has taken numerous steps to inform the public about research and care. The center has a Mobile Mammography Unit, which travels into communities to provide access to screening for breast cancer.

On June 5, at the Latina Sisters Support Inc. Spanish Fair in Brentwood, the Cancer Center’s Community Outreach and Engagement staff provided mobile mammography screening and cancer prevention and screening education.

At that event, the Suffolk County Department of Health Services provided human papillomavirus and Covid-19 vaccines and Stony Brook School of Health Professionals offered blood pressure screening.

An information chasm

Dr. Jedan Phillips. Photo from Stony Brook Medicine

Dr. Jedan Phillips, Medical Director for Stony Brook Health Outreach and Medical Education and Associate Professor of Family, Population and Preventive Medicine at the Renaissance School of Medicine, explained that Covid-19 exposed the “chasm” between what the health care profession believed and the reality of what works and what doesn’t.

During the pandemic, Stony Brook University brought a vaccination pod to Uniondale in Nassau County, which is a predominantly African American community. “Because we had no relationship there, we might have wasted over 200 doses of the vaccine” as residents were reluctant to get vaccinated, he said. “Even though [Stony Brook] offered something that would help, people chose against it. It’s not about the vaccine. It’s something deeper.”

Dr. Phillips said East Elmhurst, Queens, where he grew up, was “ravaged by Covid. I know at least 10 people in my community who were regular figures in my life that died. I saw how vulnerable of a position we were in as a group and I felt I needed to get involved.”

Dr. Phillips, who has a family medical practice in East Patchogue, together with Dr. Yuri Jadotte, Assistant Professor and Associate Program Director for the Preventive Medicine Residency in the Department of Family, Population and Preventive Medicine at Stony Brook, created three focus groups to survey the views and understanding of African American men on prostate cancer.

Many African American men don’t get screened for prostate cancer, even though such screenings could lead to earlier treatment and better outcomes.

By listening to what inspires African American men throughout Long Island to take action, Dr. Phillips hopes to tailor information to that type of delivery.

“It’s important to listen and understand,” Dr. Phillips said. Understanding what motivates people and seeking to provide the formats in which they prefer to access information can help establish a community connection and demonstrate cultural compassion.

Part of Dr. Phillips’s focus on preventive medicine comes from his experience with his father, who died from complications related to diabetes. His father, who was an inspiration for him, “didn’t live life in a preventive way,” which made managing his health more difficult, Dr. Phillips said.

With the numerous programs offered by the Office for Community Outreach and Engagement, Dr. Mermelstein said the group has four primary goals.

Dr. Jedan Phillips provides medical care.

“We want to monitor and understand what is the cancer burden in our catchment area” which includes Nassau and Suffolk County, she said. “Much of our activities are identifying the issues in terms of cancer” and understanding any barriers towards cancer care, like education, screening, diagnosis and treatment.

Secondly, she wants to provide cancer prevention services, screening, education and community navigation. Third, the group has a bi-directional engagement, with researchers getting to know the community and community advocates and the community learning about the research process.

Finally, the group seeks to catalyze the research by focusing on disparities, providing research services to the entire community based on specific needs.

One of Dr. Mermelstein’s first actions after heading up this team in 2019 was to create a community advisory council for the Stony Brook Cancer Center.

Janine Logan, Vice President of Communications and Population Health with the Long Island Health Collaborative, serves on that advisory council.“What I’m most excited about is that the committee understands the importance of knowing what your community thinks and needs,” Logan said.

Logan is pleased with the work the Stony Brook Cancer Center has done to educate residents about the lifestyle behaviors that can contribute to cancer, such as smoking, inactivity, and nutrition.

“They’ve done a lot of work in reaching out and educating communities to help them understand that these simple, modifiable behaviors can reduce their risk” of developing cancer, Logan said.

The effort at the Cancer Center to educate the public about the danger’s of the sun dovetails with some of the work she has done at the Long Island Health Collaborative.

Indeed, the Cancer Center Community Outreach and Engagement hosted a “Block the sun, not the fun” gathering on May 7 at the Smith Haven Mall in Lake Grove.

The Stony Brook Cancer Center is also working with the Suffolk County Department of Health Services Cancer Prevention and Health Promotion Coalition to provide information about sunscreen safety.

In addition to the disparity among African American men who develop prostate cancer, the outreach effort also addressed the difference among hispanic women who have a higher incidence of cervical cancer than the non-hispanic Caucasian population.

In Suffolk County, about 10.2 Hispanic and Latino women out of 100,000 Hispanic and Latino women develop cervical cancer, which is higher than the 5.9 per 100,000 for white, non-Hispanic women, according to the National Cancer Institute.

Human papillomarvirus is estimated to cause about 36,500 cases of cancer in men and women every year in the United States. The HPV vaccination, which works best before exposure to the virus, can prevent 33,700 of those cancers. Because the vaccine doesn’t prevent all cancers, women still need screening to protect themselves.

Previously employed for 22 years with the Suffolk County Department of Health Services, Dr. Mermelstein, who has a medical degree and a master’s in public health, briefly retired, before taking this job at Stony Brook.

“I wanted to do something to help address cancer after I retired, and so I contacted Stony Brook Cancer Center and began in this position about four months after I retired,” she explained.

Those interested in reaching out to the Office for Community Outreach and Engagement can call 631-444-4263 or email [email protected].

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BEST OF THE BEST The seven students who received top honors are (top row, from left) kindergartener Rebecca Tyler, first grader Violet Radonis, second grader Taran Sathish Kumar, (lower row, from left) third grader Adam Dvorkin, fourth grader Liam Savage, fifth grader Michaela Bruno, and sixth grader Rebecca Bartha. Photos from BNL
Annual contest offers Long Island, NYC students an opportunity to showcase their science projects

Should you sanitize your television remote? How can we keep apple slices looking fresh? Do dogs have a favorite color? Long Island and New York City students tackled questions of all kinds using the scientific method in the 2022 Elementary School Science Fair hosted virtually by the U.S. Department of Energy’s Brookhaven National Laboratory.

The goal of the annual competition organized by the Office of Educational Programs (OEP) at Brookhaven Lab is to generate an interest in and excitement about science and engineering for all ages.

“It’s an honor and inspiration for us to look at all of the posters by students who are joining Brookhaven in a passion for discovery,” said Scott Bronson OEP manager of K-12 programs. “Just like the scientists here at Brookhaven Lab, Science Fair participants study questions of ‘how?’ and ‘why?’ to meet science challenges.”

This year’s competition invited projects by students from Suffolk County, Nassau County and New York City schools in kindergarten through sixth grade.

From left, Northport Middle School, sixth grader Grace Rozell received an Honorable Mention and fifth grader Michaela Bruno captured First Place in her grade at the BNL Science Fair on July 10. The students are pictured with Assistant Principal Dr. Chelsea Brown and Principal Timothy Hoss. Photo from BNL

Participants qualified for the Brookhaven Lab contest by winning science fairs held by their schools. Volunteer judging teams consisting of elementary school teachers and Brookhaven Lab scientific and engineering staff evaluated a total of 189 projects.

“We were so excited to expand the Science Fair and welcome projects from students across all of Long Island and New York City,” said Amanda Horn, a Brookhaven Lab educator who coordinated the virtual science fair. “We loved seeing the projects from other areas and we hope to see even more projects in the future.”

The following students earned first place in their grade level and received medals and ribbons, along with banners to hang at their school to recognize the achievement:

◆ Kindergartener Rebecca Tyler of Miller Avenue Elementary School, Shoreham-Wading River School District, for her project, “How to get Permanent Marker Out of Clothes?” 

◆ First grader Violet Radonis of Pines Avenue Elementary School, Hauppauge School District, for “Bad Hair Days…No More! Let’s Learn about the Land of the Rapunzals”

◆ Second grader Taran Sathish Kumar of Bretton Woods Elementary School, Hauppauge School District, for “Cleaning Up Oil Spills Using Natural Organic Sorbents” 

◆ Third grader Adam Dvorkin of Pulaski Road Elementary School, Northport-East Northport School District, for “Sardine Pop in a Bathtub” 

◆ Fourth grader Liam Savage of Ruth C. Kinney Elementary School, East Islip School District, for “Weight is Tow-Tally Helpful” 

◆ Fifth grader Michaela Bruno of Northport Middle School, Northport-East Northport School District, for “Here Comes The Sun” 

◆ Sixth grader Rebecca Bartha of Raynor Country Day School in Speonk for “Super Sea Shells Save the Seas”

Young scientists share their results

OEP staff announced the winners and honorable mentions during an online awards ceremony on June 10. Students with top-notch projects shared how they conducted their experiments.

First-grader Violet Radonis asked whether rice water can make hair grow faster and stronger. After four weeks of testing a mixture of basmati rice and water—plus orange peels for a nice scent—on eight test subjects, she found: “It does help make it a little bit better than it was before.”

Orange peels also played a part in second grader Taran Sathish Kumar’s experiment. In his search for an environmentally safe sorbent to protect marine life from oil spills, his hypothesis that orange peels would remove the most oil from water was correct. He also tested a corn cob, banana peel, and a pomegranate husk. 

“Around the world when boats go in the water, oil spills from the boat and it’s harmful to the animals,” he said.

Third grader Adam Dvorkin wanted to find out what sort of pop pop (or putt putt) boat design is the fastest. He built and observed three boats, each with a different sized boiler made from a soda can bottom. The biggest boiler was the best, confirming his hypothesis. 

“My favorite part was when me and my dad had to check how fast each pop pop boat was to see which one was the fastest,” he said.

Fourth grader Liam Savage tested whether adding weights to the top of a remote-control truck would increase its towing ability. He found that a specific amount of weight increased the truck’s tower power by giving it extra traction. But with too much weight, the truck would stall. With too little weight, the truck didn’t have enough grip. “My favorite part was driving my car and seeing how much weight it could pull,” he said.

Aspiring astronaut and fifth grader Michaela Bruno searched for the best material to block ultraviolet rays for protection.”I want to be an astronaut when I grow up and I want to know how the UV lights in space affect them,” she said.

By shining a UV flashlight on UV beads covered by different materials she learned that aluminon foil and dark cotton fabric offered the best protection. With those results in mind, Bruno went on to engineer a model space suit and visor.

Honorable mentions

Kindergarten: Kacey Stidd, Riverhead; Lucas Luna, Hampton Bays; John O’Donnell, Kings Park

First Grade: Hudson Costales, East Northport; Jaxon Romano, Middle Island; Marilla Pendelton, Aquebogue 

Second Grade: Jude Roseto, Cutchogue; Ashleigh Bruno,  Northport; Kayleigh Moore, East Northport 

Third Grade: Matthew McHugh, Hauppauge; Riona Mittal, Hauppauge; Maxin Vetoshkin, Hauppauge

Fourth Grade: Evan Pereyra, Westhampton Beach; Agnes Van Winckel, Kings Park; Emma Lochner, Sayville 

Fifth Grade: Mihir Sathish Kumar, Hauppauge; Faith Andria, Remsenburg;  Madeline Croce, Sayville 

Sixth Grade: Grace Rozell, Northport; Elle Redlinger, Montau

Brookhaven National Laboratory is supported by the Office of Science of the U.S. Department of Energy. The Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time. For more information, please visit www.science.energy.gov

 

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Paolo Boffetta. Photo by Jeanne Neville/Stony Brook Medicine

By Daniel Dunaief

Screening for cancer can help people take steps to head off the development of a disease that could threaten the quantity and quality of their lives.

During the start of the pandemic, people around the world stopped screening for cervical, breast and colorectal cancer, according to a recent study led by Paolo Boffetta, Associate Director for Population Sciences at Stony Brook University’s  Cancer Center.

The results of the study were recently published in the journal JAMA Oncology.

Compared to 2019, screenings for breast cancer dropped in the first few months after the start of the pandemic by 35.6 percent for breast cancer, 41.8 percent for colorectal cancer, and 54.1 percent for cervical cancer compared to the same period in 2019.

Paolo Boffetta. Photo by Jeanne Neville/Stony Brook Medicine

Boffetta chose these three cancers because they are the ones public health authorities recommend for the population at large. Screenings can improve patient outcomes. 

“For some/ most cancer, the earlier the better for detection,” explained Stony Brook Cancer Center Director Yusuf Hannun.

Boffetta, who is also Adjunct Professor at the Icahn School of Medicine at Mount Sinai in New York City, suggested that the longer-term impact of a reduction in screenings in the early part of the pandemic won’t be clear to doctors or patients in the short term.

“It will take a little bit of time to have a full understanding of this,” said Boffetta. Depending on the specific type, cancers “that are detected by screenings would not otherwise appear for a few years.”

Boffetta suggested that the pandemic, apart from the illnesses and symptoms that threatened the health of people who were battling the virus itself, affected public health services. He believes several factors likely contributed to the decrease in screenings. Patients around the world were reluctant or restricted in their ability to leave their homes amid lockdowns.

Additionally, some cancer centers likely reduce the number of people they monitored to cut back on the density of patients in health care facilities, although Boffetta did not gather any data on the reduction in the number of screenings at health care centers.

The positive news amid this study, which surveyed cancer screening data in PubMed and other medical journals from 19 countries from January 2020 through December 2021, was that the number of patients screened returned to a more normal level within several months of the start of the pandemic.

“An important finding is that by the summer of 2020, the decrease in screenings for breast cancer and cervical cancer seem to have disappeared,” Boffetta said by phone from Italy, where he is a part-time professor at the University of Bologna. “For colorectal cancer [the decrease in screenings] lasted longer,” through the end of 2020.

Boffetta described the reduction in screenings and then a return to normal as a U-shaped curve, with an initial decline followed by a recovery. Doctors typically screen for colorectal cancers by using a colonoscopy. This technique requires several hours in the hospital. Patients may have been “more reluctant to go back to such a complex procedure, compared to the mammography or pap smear” which screen for breast and cervical cancers, respectively.

Boffetta is conducting a broad study of the cancer literature from early findings to clinical diagnosis to treatment. At this point, he has finished a paper on the frequency and types of clinical diagnoses amid the pandemic. He is collecting data for another study that will examine cancer treatment.

“We are interested in how the pandemic affected each of these stages,” he said.

Hannun suggested that Boffetta’s work expertise help address important health care questions related to the pandemic and other threats to public health, adding, “Epidemiology is essential for understanding the pandemic and many chronic diseases, especially cancer with exposure issues.

A lab update

Boffetta joined Stony Brook University in April of 2020, soon after the start of the pandemic.

Also a Professor in the Department of Family, Population and Preventive medicine at the Renaissance School of Medicine at Stony Brook University, Boffetta will return to the United States in a few weeks from Italy.

Boffetta has added Research Coordinator Germana Giupponi and postdoctoral fellow Malak Khalifeh to his research efforts at Stony Brook. 

Germana Giupponi

A native of Italy, Giupponi, who started working with Boffetta in July of 2020 and provides administrative support and coordination with Boffetta’s collaborators, earned her master’s degree from the University of Milan.

Khalifeh joined Boffetta’s lab in March, is originally from Lebanon and conducted her PhD research in France at the University of Bordeaux. She is studying the link between the exposure people have to various chemicals in drinking water and bladder cancer. The bladder is especially susceptible to toxins from the environment.

Boffetta, meanwhile, has started teaching some graduate level classes at Stony Brook on cancer epidemiology for master’s and PhD students. He will teach one class this fall.

He is also continuing his studies with survivors of the World Trade Center attacks.

He has been comparing the survival of these first responders to the overall population in New York, comparing how the risk of cancer changed over the course of the 21 years since the attacks.

Boffetta has been working with Ben Luft, Director of the Stony Brook WTC Wellness Program at the Renaissance School of Medicine. Luft has provided clinical and research support for WTC responders.

Boffetta continues to have academic affiliations with other academic institutions, including Harvard University and Vanderbilt University.

Boffetta and his wife Antonella Greco, who have been living in New York City, plan to move to the Stony Brook area. Their three daughters live in Brooklyn, Italy and Argentina. Now that pandemic restrictions have lifted, Boffetta has been able to return to the opera and museums and has done some skiing and hiking.

As for this study, Boffetta suggested that the findings about screenings were consistent with what he might have expected during the beginning of the pandemic.Delaying screenings could mean that some people discover cancers at a more advanced state by the time they diagnose them, he said.

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The tip of the ‘wing’ of the Small Magellanic Cloud galaxy NASA photo

As part of its Summer Sunday series, Brookhaven National Laboratory is bringing science to the Suffolk County Vanderbilt Planetarium, 180 Little Neck Road, Centerport on July 17 with a program titled SPACE from 9:30 a.m. to 2 p.m. Join scientists from BNL as they discuss the wonders of the universe and take turns with hands-on experiences that show the different weights in different planetary gravities, explore craters of the moon, and more! Admission is free to the public until 2 p.m.

Visitors will have access to the grounds as well as exhibits in the Vanderbilt Mansion and Hall of Fishes marine museum. Seating for the scientific talks and Planetarium shows require reservations. Please click on any program segment below to reserve your seat.

10:00 am – “The Invisible Universe.” Scientist Steven Bellavia of Brookhaven Lab’s Collider-Accelerator Department will share his talk about the universe (45 minutes).

11:00 am – “Can We See the Flag on the Moon?” Scientist Steven Bellavia of Brookhaven Lab’s Collider-Accelerator Department will share his talk about the flag on the moon (45 minutes).

Noon – “One World, One Sky” Planetarium astronomy show (45 minutes). Elmo and Big Bird live in the United States and Hu Hu Zhu lives far away in China, but they discover they see the same stars at night.

1:00 pm – “A Guide to Galactic Cosmic Rays: Studying Space Particles at Brookhaven National Lab.” Scientist Jessica Gasparik of Brookhaven Lab’s NASA Space Radiation Laboratory will speak about galactic cosmic rays (45 minutes).

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The SK 48 cranium of an ancient hominin, Paranthropus robustus, was one of the fossils included in the analysis of some new claims on human evolution. Photo by Carrie S. Mongle

Uncovering the evolution of any set of living creatures is a complex and highly detailed task for scientists, and theories and approaches that may differ over time may indeed change the fossil record. But paleoanthropologist and Stony Brook University Professor Carrie S. Mongle, PhD, and co-authors urge investigators to take caution on their findings. They provide researchers investigating the evolutionary past of ancient hominins (a group including humans and our immediate fossil ancestors) an important and foundational message in a recent paper published in Nature Ecology & Evolution. That is – conclusions drawn from evolutionary models are only as good as the data upon which they are based.

In “Modelling hominin evolution requires accurate hominin data,” the authors develop a response to a previous research paper that had made some major claims on when the genus Homo emerged based on fossil dates. The team, however, proved that many of the fossil dates from the study were wrong, and they provided data to correct these errors.

“It has become increasingly common in our field for researchers to propose a ‘new and exciting’ synthesis of evolutionary events that a given group of scientists think overturns our understanding of human evolution,” says Mongle, Assistant Professor in the Department of Anthropology and Turkana Basin Institute. “Our paper is meant to draw attention to the issue that we cannot make major claims based on piecemeal compilations of the fossil record and questionable data from literature. We also offer a carefully constrained geochronological dataset for researchers to use for future studies.”

Mongle and co-authors found that by re-analyzing the original study with corrected fossil dates, the estimated timing of species divergences differed by as much as 300,000 years from the previously reported estimates. This is important because these estimates are often used to correlate evolutionary transitions with ancient environments and climate change. When estimates are off by this much, it can completely change scientists’ interpretations of the evolutionary drivers that made us human.

Mongle and co-authors make the case for evolutionary scientists to develop future total evidence studies when studying human evolution. They conclude that it is “critical to recognize that no algorithm is a replacement for careful comparative anatomy and meticulously constrained geochronology when it comes to interpreting evolutionary trends from the fossil record.”

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Sechrist model chamber for hyperbaric oxygen therapy. Photo courtesy Renee Novelle

Port Jefferson’s St. Charles Hospital will open its new Center for Hyperbaric Medicine & Wound Healing on July 18, as the hospital seeks to help people with chronic, nonhealing wounds.

The center, which will be located on the second floor of the hospital, will include two hyperbaric chambers that provide 100% pure oxygen under pressurized conditions and will have four examining rooms.

The chamber “provides patients with the opportunity to properly oxygenate their blood, which will increase wound healing and wound-healing time,” said Jason Foeppel, a registered nurse and program director for this new service.

Potential patients will be eligible for this treatment when they have wounds that fail to heal after other treatments for 30 days or more.

Residents with circulatory challenges or who have diabetes can struggle with a wound that not only doesn’t heal, but can cause other health problems as well.

More oxygen in people’s red blood cells promotes wound healing and prevents infection.

The treatment “goes hand in hand to deliver aid to the body’s immune system and to promote a healing environment,” Foeppel said.

Nicholas Dominici, RestorixHealth regional director of Clinical Operations; Ronald Weingartner, chief operating officer, St. Charles Hospital; Jim O’Connor, president, St. Charles Hospital; and Jason Foeppel, program director. Photo courtesy Renee Novelle

St. Charles is partnering with RestorixHealth in this wound healing effort. A national chain, RestorixHealth has created similar wound healing partnerships with other health care facilities in all 50 states.

The new wound healing center at St. Charles is one of several others on Long Island, amid an increased demand for these kinds of services.

Partnering with Healogics, Huntington Hospital opened a hyperbaric chamber and wound healing center in May 2021. Stony Brook Southampton Hospital also has a wound care center.

“There’s a great need for this in our community,” said John Kutzma, program director at the Huntington Hospital center. “We know that there are 7 million Americans living with chronic wounds,” many of whom did not receive necessary medical attention during the worst of the pandemic, as people avoided doctors and hospitals.

Concerns about contracting COVID-19 not only kept people from receiving necessary treatment, but also may have caused nonhealing wounds to deteriorate for people who contracted the virus.

Although Kutzma hasn’t read any scientific studies, he said that, anecdotally, “We’ve had patients that had COVID whose wounds haven’t healed as quickly as non-COVID patients.”

Patients at the Huntington Hospital center range in age from 15 to 100, Kutzma said. People with diabetes constitute about one-third of the patients.

Treatment plan

For the hyperbaric chamber to have the greatest chance of success, patients typically need daily treatments that last between one and a half to two hours, five days a week for four to six weeks. While the time commitment is significant, Foeppel said it has proven effective in wound healing studies.

“We pitch it as an antibiotic treatment,” he said. “You want to complete that full cycle to ensure the body has enough time to complete the healing process.”

Kutzma said Huntington Hospital reviews the treatment plan with new patients.

In following the extensive treatment protocol to its conclusion, he said, “The alternative is to live with this very painful, chronic wound that may lead to amputation.” Given the potential dire alternative, Huntington Hospital doesn’t “have a problem getting that kind of commitment.”

While the treatment has proven effective for many patients, not everyone is medically eligible for the hyperbaric chamber.

Colin Martin, safety director. Photo courtesy Renee Novelle

Some chemotherapy drugs are contraindicators for hyperbaric oxygen treatments. Those patients may have other options, such as skin grafts, extra antibiotics or additional visits with physicians for debridement, which involves removing dead, damaged or infected tissue.

“We invite patients to come in, go through the checklist and see what their plan of attack” includes, Foeppel said.

The cost of the hyperbaric treatment for eligible conditions is generally covered by most health insurance plans, including Medicaid and Medicare, he said. 

The two hyperbaric chambers at St. Charles can treat eight to 10 patients in a day.

Aside from the cost and eligibility, patients who have this treatment frequently ask what they can do during their treatments. The center has a TV that can play movies or people can listen to music.

“We don’t expect you to sit there like in an MRI,” Foeppel said.

As for complaints, patients sometimes say they have pressure in their ears, the way they would if they ascend or descend in an airplane. The center urges people to hold their nose and blow or to do other things to relieve that pressure.

Foeppel encourages patients to use the restroom before the treatment, which is more effective when people don’t interrupt their time in the chamber.

Prospective patients don’t need a referral and can call the St. Charles center at 631-465-2950 to schedule an appointment.

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Markus Seeliger, third from left, with members of his lab, from left, Terrence Jiang. Aziz Rangwala, Ian Outhwaite, Victoria Mingione,YiTing Paung, and Hannah Philipose. Photo from Markus Seeliger

By Daniel Dunaief

When a dart hits the center of a target, the contestant often gets excited and adds points to a score. But what if that well-placed dart slipped off the board before someone could count the points, rendering such an accurate throw ineffective?

With some cases of cancer treatments, that’s what may be happening, particularly when a disease develops a mutation that causes a relapse. Indeed, people who have chronic myeloid leukemia typically receive a treatment called Imatinib, or Gleevac.

The drug works, hitting a target called a kinase, which this white blood cell cancer needs to cause its cells to continue to divide uncontrollably. Patients, however, develop a mutation called N368S, which reduces the effectiveness of the drug.

While mutations typically make it more difficult for a drug to bind to its target, that’s not what’s happening with this specific mutation. Like the dart hitting the center of a board, the drug continues to reach its target.

Instead, in a model of drug resistance several scientists have developed, the mutation causes the drug to decouple.

Pratyush Tiwary with this year’s US top 20 students who are going to the international chemistry olympiad. Photo from Toward

A team of experimental and computational researchers including Markus Seeliger, Associate Professor of Pharmacological Sciences at Stony Brook University, and Pratyush Tiwary, Associate Professor in the Department of Chemistry & Biochemistry at the University of Maryland, published two research papers explaining a process that may also affect the way mutations enable resistance to other drugs.

Seeliger described how different disease-associated mutations bind to Gleevac in a paper published in the Proceedings of the National Academy of Sciences. 

Working with scientists at Memorial Sloan Kettering Cancer Center and Goethe University in Frankfurt, Germany, Seeliger used nuclear magnetic resonance spectroscopy, or NMR. The researchers showed how the drug bound to its target and then released.

Understanding the way diseases like cancer develop such resistance could affect drug discovery, giving pharmaceutical companies another way to prepare for changes diseases make that reduce the effectiveness of treatments.

A ‘hot paper’

Tiwary published research in which Seeliger was a coauthor in late April in the journal Angewandte Chemie that the publication labeled a “hot paper” for its implications in the field. Tiwary developed a way to simulate the kinetic processes that enable the mutated kinases to release the drug.

Tiwary created an artificial intelligence model that extended the time he analyzed the drug-protein interaction from milliseconds all the way out to thousands of seconds.

“Even within the simulation world, if you can quantitatively predict a binding affinity, that’s amazing,” Seeliger said. “It’s extremely hard to calculate kinetics, and he got that right.”

Tiwary, who started talking with Seeliger about five years ago and has been actively collaborating for about three years, uses experimental data to inform the dynamics that affect his simulations.

Seeliger “had done the experiments of the dissociation rates beforehand, but did not have a way to explain why they were what they were,” Tiwary explained in an email. “Our simulations gave him insights into why this was the case and … insight into how to think about drugs that might dissociate further.”

Drug discovery

Tiwary hopes the work enables researchers to look at structural and kinetic intermediates in reactions, which could provide clues about drug design and delivery. While he worked with a single mutation, he said he could conduct such an analysis on alterations that affect drug interactions in other diseases.

He wrote that the computations, while expensive, were not prohibitive. He used the equivalent of 16 independent 64 CPUs for one to two weeks. He suggested that computing advances could cut this down by a factor of 10, which would enable the exploration of different mutations.

“The methods are now so easy to automate that we could run many, many simulations in parallel,” Tiwary explained. Machine learning makes the automation possible.

Given what he’s learned, Tiwary hopes to contribute to future drug begin that addresses mutation or resistance to treatment in other cancers. He also plans to continue to work with Seeliger to address other questions.

Next steps

Seeliger said he plans to extend this work beyond the realm of this specific type of cancer.

He will explore “how common these kinetic mutations are in other systems, other diseases and other kinases,” Seeliger said.

He would also like to understand whether other proteins in the cell help with the release of drugs or, alternatively, prevent the release of drugs from their target. The cell could have “other accessory proteins that help kick out the drug from the receptor,” Seeliger said.

The concept of drug resistance time comes from infectious disease, where microbes develop numerous mutations.

Seeliger, who is originally from Hanover, Germany, said he enjoys seeing details in any scene, even outside work, that others might not notice. 

He described how he was driving with postdoctoral fellows in Colorado when he spotted a moose. While the group stopped to take a picture, he noticed that the moose had an ear tag, which is something others didn’t immediately notice.

As for the research collaboration, Seeliger is pleased with the findings and the potential of the ongoing collaboration between experimental and computational biologists.

“The computational paper, aside from using interesting new methodology, describes why things are happening the way they are on a molecular level,” he said.

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