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By Leah S. Dunaief

Leah Dunaief

We seem to be living at a higher level of anxiety. Maybe not all of us. Somewhere there might be one or two souls who are still calmly oblivious to the world around us. Those are the ones who have turned off their televisions and radios, who don’t read newspapers and have put away their cellphones. But from conversations I have had, that’s not the rest of us. The rest of us are quietly, or not so quietly concerned.

What’s wrong? Let’s make a list. Better yet, let’s not. Instead, let’s think about how to cope.

One way to start is to divide what troubles us into two lists: those we can do something about and those we cannot. Then concentrate on the former. When confronted with hate, we can respond with kindness. We can listen rather than scream. We can do our tiny bit to help make our neighborhood a better place.

A psychotherapist I was interviewing recently told me she instructs her anxious clients to concentrate on their breathing, taking deep breaths for ten minutes to calm the body. The usual trio of eating, sleeping and exercising properly are critically important to maintain. Meditation, and even aromatherapy may also help. 

Specifically:

Exercise regularly. It’s good for both body and mind. One recent study revealed that “people with physically active lifestyles had about 60 percent lower risk of developing anxiety disorders,” according to healthline. This study was done over 21 years and followed 400,000 participants.

How does exercise work? For one, it provides a distraction from whatever is worrying. Also, getting the heart rate up changes brain chemistry, encouraging the secretion of anti-anxiety brain messengers like serotonin and gamma-aminobutyric acid (GABA). According to the American Psychological Association, “regular exercise leads to an enhancement of concentration and willpower, which can help certain anxiety symptoms.” 

Plus you feel good, especially when you stop. Walking is the simplest and perhaps most enjoyable way to exercise, particularly at this time of year, when it is not too hot nor too cold, and the changing colors of the foliage are a delight.

Eating a balanced diet, and eating it calmly, is important. Low blood sugar levels, dehydration and chemicals in processed foods, such as artificial flavorings, artificial coloring and preservatives can cause mood changes. A high-sugar diet can also have a negative reaction. So what should we eat? Fruits and vegetables, especially those leafy dark green ones rather than those high in starch, are ideal. After that, complex carbohydrates and beans, are a good source of nutrition. I happen to like fish, the white fleshy kind like sea bass, rather than lean meat, for animal protein. But remember, there is plenty of protein in veggies and beans.

Sleep is so important. A good night’s sleep leaves me feeling as if, the next day, I could “leap tall buildings at a single bound,” to borrow from the Superman tagline. Ah, but how to get a good night’s sleep? I am a good sleeper, and I will tell you what I do—most of the time.

I don’t watch television or use my computer or cellphone before going to bed. Something about that blue light wakes me up. I don’t even have those in my bedroom. I will sometimes read a bit, but not a page turner. My room is the coolest in the house, and I will frequently have the window open, even a tiny bit, in winter. I know that going to bed the same time each night is recommended, though I don’t always follow that advice. Also no alcohol before bedtime is also advised. It helps put me to sleep but I will be wide awake when the alcohol wears off in the middle of the night. And, I invested in a comfy down comforter years ago that, with its plushness, invites me into bed.

Better not to nap during the day, and that leaves me sufficiently tired by bedtime, especially if I have exercised. At least, it should. If it doesn’t, I will empty my thoughts onto a list, put the pad on the bedside table, then doze off.

Pixabay photo

By Bob Lipinski

Bob Lipinski

Many years ago, as a young journalist, I often heard that Beaujolais was intended to be drunk while still very young, and if over a year old, lost its appeal and charm and is best forgotten. Older journalists jokingly referred to Beaujolais Nouveau as ‘Old Veau’ once it surpassed a year of aging.

Having explored the Beaujolais wine region in France and sampled numerous “older” vintages, I can confirm that the earlier advice was inaccurate. Interestingly, some Beaujolais wines can still be enjoyed after ten years of aging. During a visit to Beaujolais, I had the chance to taste some truly spectacular wines that were approaching 15 years old.

Beaujolais wine is made from the Gamay grape, known for its light-bodied fruity character and flavors of berries (raspberry and strawberry), red cherries, candy-apples, watermelon, and others.

Yet, when the Gamay grape is grown in the northern topography on hillside properties, the wines become riper, fuller-bodied, and more complex. These wines are often aged in wooden barrels for several years, losing much of their grapey character.

Beaujolais wine is grouped into three levels depending on quantity, quality, and price. Beaujolais (also Beaujolais Nouveau), Beaujolais-Villages, and Beaujolais Cru. Beaujolais-Villages is sourced from 38 villages in the north, known for its superior quality and subsequent higher price. The crus of Beaujolais, originating from 10 specific northern villages, are intended for aging and are of the highest quality.

Pixabay photo

My Beaujolais tasting notes are:

2019 Georges Duboeuf “Beaujolais Nouveau.” It lost some of its intense fruit because of age. Bright ruby color with a light and fruity aroma and flavor of red candy, raspberries, and cranberry, with a tart-berry aftertaste.

2021 Domaine Romy “Les Pierres Dorées” (Territory of Golden stones) Beaujolais. Cherry color with a fruity aroma and flavor of raspberries, spicy cherries, tart berries, and red currants. There are hints of black pepper and plums in the aftertaste.

2019 Prunelle de Navacelle “Beaujolais Lantignié” (Beaujolais-Villages). (Aged 12 months in oak). Floral bouquet and taste of spicy black fruits, herbs, jam, and mushrooms. Nice amount of acidity with hints of strawberries, earth, leather, and hibiscus.

2019 Stephane Aviron Moulin-à-Vent “Vieilles Vignes” Beaujolais. Ruby-colored with an impressive bouquet and taste of black cherry, boysenberry, black currants, and bittersweet chocolate. Medium-bodied with hints of wild strawberry, spices, black pepper.

2018 Louis Latour “Beaujolais-Villages.” Medium-deep color with a fruity bouquet and taste of cranberry, raspberry, and black cherry. Additional flavors of almonds, plums, and jam are balanced by crisp acidity.

Bob Lipinski is the author of 10 books, including “101: Everything You Need To Know About Whiskey” and “Italian Wine & Cheese Made Simple” (available on Amazon.com). He consults and conducts training seminars on Wine, Spirits, and Food and is available for speaking engagements. He can be reached at www.boblipinski.com OR [email protected]

Photo by Lisa Mcgrath

A LOCAL TREASURE

Lisa Mcgrath of Stony Brook took this beautiful photograph of the historic Gamecock Cottage (built in 1876) at West Meadow Beach on October 2nd. 

She writes…”While walking on this glorious day at our local beach after so many days of rain, I realized what a constant and beautiful backdrop the cottage is throughout the changing seasons. There were people fishing and enjoying the sunshine as well. It reminded me what a special place we live in.”

Send your Photo of the Week to [email protected]

SCWA offers customer account credits of up to $150 for the purchase of water-saving devices.
A Column Promoting a More Earth-Friendly Lifestyle

By John L. Turner

John Turner

In your travels you’ve probably seen in-ground lawn sprinklers watering someone’s yard or a corporate lawn in the midst of a downpour. Such a scene indicates a system lacking a rain sensor, a device that prevents an irrigation system from operating when it’s raining or shortly after it’s rained. 

If you have an irrigation system but lack a rain sensor this piece of equipment can save you money in the long run and help conserve water. Misuse of water can result in lowering the water table elevations in our vulnerable aquifer system  resulting in the drying up of wetlands adversely affecting wetland dependent wildlife species such as turtles, fish, and frogs. It can also result in salt water intrusion in coastal areas which can be detrimental to public water supply wells. 

We each have a role to play in safeguarding our drinking water supply, so if you have an in-ground irrigation system but lack a rain sensor why not purchase one and install it. As an incentive the Suffolk County Water Authority is offering a $75 “water wise” credit for rain sensors and a $150 “water wise” credit for smart irrigation controller/timers. Information is available at www.scwa.com/waterwise. Not only will these devices ensure you don’t waste water but over the long term will put a few extra dollars in your pocket.

A resident of Setauket, author John Turner is conservation chair of the Four Harbors Audubon Society, author of “Exploring the Other Island: A Seasonal Nature Guide to Long Island” and president of Alula Birding & Natural History Tours.

 

Lemon-Ginger Scones

By Heidi Sutton

November is here and that means that the holiday season is just around the corner. Entertaining for the holidays frequently involves welcoming overnight guests. In these instances, having breakfast and brunch foods on hand can ensure that those spending the night will have something tasty to eat when they rise in the morning. Make-ahead foods, such as scones, can be ideal because they are delicious at room temperature, which means you can accommodate guests who are early risers as well as those who prefer to sleep in.

This recipe for “Lemon-Ginger Scones” from Simply Scratch by Chef Laurie McNamara produces refreshing flavor in a buttery scone. Lemony, with a subtle ginger flair, they are finished off with a thick layer of powdered sugar. Serve with tea or coffee and your guests will be in heaven.

Lemon-Ginger Scones

YIELD: Makes 8 scones

INGREDIENTS:

1⁄2 cup cold heavy cream

2 large eggs

1 teaspoon organic lemon extract

1⁄2 teaspoon pure vanilla extract

2 1⁄4 cups unbleached all-purpose flour, plus more for dusting

3 tablespoons granulated sugar

1 tablespoon baking powder

1⁄4 teaspoon kosher salt

3⁄4 cup (11⁄2 sticks) cut into cubes

1⁄4 cup finely diced candied ginger

2 tablespoons grated lemon zest

1⁄4 cup powdered sugar

DIRECTIONS:

Preheat the oven to 400 F. Line a rimmed baking sheet with a silicone baking mat or parchment paper. In a 2-cup liquid measuring cup, use a fork to beat together the heavy cream, eggs, lemon extract, and vanilla until combined. Chill until ready to use.

In a large bowl, combine the flour, sugar, baking powder, and salt. Drop in the ice-cold butter and use a pastry cutter to cut the butter into the flour mixture until it resembles coarse wet sand.

Pour in the chilled cream mixture, ginger and lemon zest and use a rubber spatula to stir until just combined.

Turn the dough onto a lightly floured work surface and knead it a few times before forming it into a ball. With floured fingers, flatten it out into a 11⁄2-inch-thick round. Cut the round into 8 equal-sized wedges and transfer them to the prepared baking sheet.

Bake for 15 to 18 minutes, rotating the baking sheet halfway through baking. Transfer the baked scones to a wire rack to cool. Once the scones have cooled, dust generously with powdered sugar before serving.

Note: According to Chef Laurie McNamara, the key to any good scone recipe is using ice-cold ingredients, so cube the butter and keep it in the freezer, and keep everything else, with the exception of the dry ingredients, measured and combined in the fridge until you are ready to mix them in.

A cluster of cranberries. Pixabay photo

By John L. Turner

John Turner

In a few weeks you’ll most likely be sitting down around a table with family members to enjoy an annual Thanksgiving Day meal with all the fixings: turkey, stuffing and gravy, mashed and sweet potatoes, green beans, and cranberries or cranberry sauce. The cranberries and/or sauce probably came from a commercial bog in Wisconsin, Massachusetts, Oregon, or New Jersey, the states where large commercial cranberry bogs exist today. 

And here’s a surprise: If you had sat down to this same blessed feast about a century ago, there’s a strong likelihood the cranberries you enjoyed were harvested from a commercial bog situated somewhere on Long Island, probably from one of a dozen or so located in the Pine Barrens. Indeed, a century to a century and a half ago Long Island was the third largest supplier of cranberries to the nation.         

Cranberries, being related to blueberries and other heaths, have an affinity to sandy, acid soils so the Long Island Pine Barrens, or more specifically wetlands in the Pine Barrens, provided highly suitable habitat to create bogs and cultivate cranberries.  

Most of these commercial bogs were located within the large watershed of the Peconic River, flowing easterly through the Pine Barrens, including three of the river’s four tributaries — the Fox/Sandy Pond area, Swan Pond, and the Swezey’s Pond/Little River draining north from Wildwood Lake — and on the main stem of the river itself just west of where Edwards Avenue crosses over it (just north of Exit 71 of the Long Island Expressway). 

Long Island’s first cranberry bog was established on the Brown’s River in Bayport around 1870; today most of it is within the 316-acre San Souci County Park and Camp Edey, a 95-acre owned by the Suffolk County Council of Girl Scouts.    

The Woodhull Bog, where Cranberry Bog County Nature Preserve is situated, was perhaps the most commercially successful bog but its success was far from a sure bet when the Woodhull brothers embarked on their effort to convert low-lying swamp habitat to a cranberry bog. Here, they spent four years, beginning in 1885 years, ripping out countless trees and shrubs, damming up the Little River tributary with an earthen dike, placing a several inch blanket of sand on the organic peat of the bog, installing perimeter and internal ditches throughout the bog to ensure rapid water coverage, and, of course, planting thousands of cranberry vines. (With the adoption of the New York State Freshwater Wetlands Act, and local wetland laws, this kind of activity fortunately cannot legally happen now on Long Island). 

Workers harvest cranberries by flooding the area. Pixabay photo

In 1889 the first harvest was achieved with a whopping 10 bushels provided by the bog. The next year was better with 90 bushels produced and the upward trend continued in 1891 with 500 bushels. In 1892 the  vines were three to four years old and had really matured and the tally for the year shows, with 21,100 bushels, going for about $2 a bushel, at market.  For many years after that the bog remained profitable and productive.  Other bogs like the Brown’s Bog in Calverton and the Davis Bog further west in Manorville were also productive and profitable. No wonder they called it Red Gold!

In the early years cranberries were picked by hand, the hands provided by hundreds of residents who gained supplemental income each autumn harvesting berries. Bog operators used a simple but ingenious strategy to ensure maximum crop harvest among the distracted workers busily chatting and socializing while picking.  They laid down parallel rows of  string like bowling alleys; each picker had an easier job of making sure all the berries within their “alley” were harvested.  

The cranberry scoop was soon invented and provided a more efficient means to harvest berries. The wooden scoop, a popular item in antique stores, had tines like a fork,  spaced apart a distance just slightly less than the width of a cranberry.  Scoops gave way to mechanized equipment that was more efficient still and once bog owners/operators learned that ripe cranberries float they began to flood the vine-filled bogs and turned to powerful vacuum hoses to suck up the crop. You may have seen Ocean Spray commercials with harvesters up to their chests in a bright red surface of floating berries. Today, a few  people can do the job that once required dozens. 

Flooding the bogs, also done to prevent a seasonal frost from destroying the crop, and over the winter to protect the vines from freezing temperatures, meant a reliable water supply had to be available and this was the case for every Long Island bog. 

For the Woodhull Bog this was the water from Swezey’s Pond, created by the aforementioned earthen berm. For the Davis Bog, water was supplied from Swan Pond. When an operator wished to flood the bogs to protect the berries or vines, or to facilitate autumn harvest, they would remove the wooden boards nestled in the concrete part of the dam next to the water supply source and install the boards at the outlet of the bog. A motor would kick on and spin a driveshaft attached to a large belt connected to a paddlewheel and water would quickly flood the bog. In spring the reverse would occur. 

A cranberry bush. Pixabay photo

To allow for bees and other pollinators to access the cranberry flowers (the name cranberry is thought to have derived from the name “crane berry”, a reference to how the flowers look similar to the head of a crane) boards would be installed in the slots of the concrete dam next to the water supply and boards removed from the far end of the bog, thereby draining it.     

By the 1920’s nearly a dozen bogs were in operation here. But about 15 years later it was down to six, according to a fine article by Tim Huss published in the New York Almanack. Long Island had several problems that made cranberry production less profitable — there were no processing facilities to make value-added products and the costs of labor and land were higher, reflected in higher property taxes, when compared with other more rural areas.

Cranberries, like most agricultural monocultures, are afflicted by pests and such was the case with Long Island’s cranberry bogs. Two notorious pests were (and still are) the cranberry fruit worm and black-headed fireworm which affects both the fruit and leaves. Cranberry producers turned to chemical means in an attempt to control the insects, with amino triazole being the pesticide of choice. This pesticide soon was in the crosshairs of the then Department of Health, Education and Welfare (HEW). 

On “Cranberry Black Monday,” November 9, 1959, HEW declared amino triazole a carcinogen (cancer causing). The cranberry market was dealt a severe blow with even Mamie Eisenhower declaring she was foregoing the traditional cranberry sauce at the White House Thanksgiving Dinner in a few weeks, serving apple sauce instead. Untold cartons and cans of cranberries and sauce languished on supermarket and warehouse shelves.      

A cluster of cranberries. Pixabay photo

The Davis Bog in Manorville was the only cranberry bog to survive this event. For years they sold their berries to the Great Atlantic & Pacific Tea Company (remember A&P supermarkets around Long Island?), but the bogs south of Swan Pond were harder and harder to maintain and in 1974 this last cranberry bog ceased operation. The Long Island cranberry industry was no more. 

If you want to gain some sense of the industry that was once so vital to Long Islanders both as a source of food and employment, a visit to the Suffolk County Cranberry Bog Nature Preserve south of the Suffolk County Center in Riverhead is in order. A small dirt parking lot provides parking and a wide trail leads to Swezey’s Pond which was the water supply source to the Woodhull Bog. 

A picturesque trail runs around the pond (I like to walk it in counter-clockwise fashion) and by hiking the trail you’ll see where sand was excavated to make the earthen dike, the dike itself, a few of the perimeter ditches that once lined the edge of the bog, and a concrete pump house near where the stream drains from the pond into the bog. If you visit during the warmer months you should see turtles, numerous birds, dragonflies, and waterlilies. Better yet, go in the colder weather, say the day after Thanksgiving, as a way to burn off the calories from all that turkey, gravy, and cranberry sauce you ingested with relish the day before.       

A resident of Setauket, author John Turner is conservation chair of the Four Harbors Audubon Society, author of “Exploring the Other Island: A Seasonal Nature Guide to Long Island” and president of Alula Birding & Natural History Tours.

Miss Baker

This week’s featured shelter pet is Akneada Baker, an 8-year-old calico up for adoption at the Smithtown Animal Shelter.

Akneada (pronounced Anita) Baker earned her name because she loves to sing and move her feet like she’s kneading. She was found as an emaciated and underweight stray with severe dental problems that had infected her sinuses and upper airway. She has since had an incredible recovery, and she’s now back to a healthy weight and is looking amazing.

Akneada is a little ball of happiness and constant motion. All she needs is a home that will love her and pet her all day long. Sweet Akneada Baker is ready to find her happily ever after, and we can’t wait for her to end up in that special home.  Will that be with you?

If you would like to meet Miss Baker, please call ahead to schedule an hour to properly interact with her in a domestic setting.

The Smithtown Animal & Adoption Shelter is located at 410 Middle Country Road, Smithtown. Visitor hours are Monday to Saturday from 10 a.m. to 3 p.m. (Sundays and Wednesday evenings by appointment only). For more information, call 631-360-7575 or visit www.townofsmithtownanimalshelter.com.

Image from METRO
Increasing fiber consumption is crucial

By David Dunaief

Dr. David Dunaief

According to the Centers for Disease Control and Prevention, about 6.7 percent of U.S. adults over the age of 19 have coronary artery disease (CAD), the most common type of heart disease (1). Annually in the U.S., there are 805,000 heart attacks. Of these, 200,000 occur in those who’ve already had a first heart attack.

Among the biggest contributors to heart disease risk are high blood pressure, high cholesterol, and smoking. In addition, if you have diabetes or are overweight or obese, your risk increases significantly. In addition, lifestyle factors contribute to your risk; poor diet, lack of physical activity and high alcohol consumption are among the most significant contributors.

This is where we can dramatically reduce the occurrence of CAD. Evidence continues to highlight lifestyle changes, including diet, as the most important factors in preventing heart disease. Key changes that pack a wallop include the consumption of chocolate, legumes, nuts, fiber and omega-3 polyunsaturated fatty acids (PUFAs).

Chocolate – really?

Preliminary evidence shows that two pieces of chocolate a week may decrease the risk of a heart attack by 37 percent, compared to those who consume less (2). The benefit may be attributed to micronutrients referred to as flavanols. 

However, the authors warned against the idea that more is better. High fat and sugar content and chocolate’s caloric density may have detrimental effects when consumed at much higher levels. There is a fine line between potential benefit and harm. 

I usually recommend that patients have one to two squares — about one-fifth to two-fifths of an ounce — of high-cocoa-content dark chocolate daily. Aim for chocolate labeled with 80 percent cocoa content.

Alternatively, you can get the benefits without the fat and sugar by adding unsweetened, non-Dutched cocoa powder to a fruit and vegetable smoothie.

Who says prevention has to be painful?

Will increasing dietary fiber help?

We can significantly reduce our risk of heart disease if we increase our consumption of fiber to reach recommended levels. Good sources of fiber are fruits and vegetables eaten with edible skin or peel, beans and lentils, and whole grains.

Fiber has a dose-response relationship to reducing risk. In other words, the more fiber you eat, the greater your risk reduction. In a meta-analysis of 10 studies, results showed that for every 10-gram increase in fiber, there was a corresponding 14 percent reduction in the risk of a cardiovascular event and a 27 percent reduction in the risk of heart disease mortality (3). The authors analyzed data that included over 90,000 men and 200,000 women.

According to a 2021 analysis of National Health and Nutrition Examination Survey (NHANES) data from 2013 to 2018, only 5 percent of men and 9 percent of women get the recommended daily amount of fiber (4). The average American consumes about 16 grams per day of fiber (5).

So, how much is “enough”? The Academy of Nutrition and Dietetics recommends 14 grams of fiber for each 1,000 calories consumed, or roughly 25 grams for women and 38 grams for men (6).

Legumes have an outsized effect

In a prospective (forward-looking) cohort study, the First National Health and Nutrition Examination Survey Epidemiologic Follow-up Study, legumes reduced the risk of coronary heart disease by a significant 22 percent (7). Those who consumed four or more servings per week saw this effect when compared to those who consumed less than one serving per week. The legumes used in this study included beans, peas and peanuts. There were over 9,500 men and women involved, and the study spanned 19 years of follow-up.

I recommend that patients consume at least one to two servings a day. Imagine the impact that could have, compared to the modest four servings per week used to reach statistical significance in this study.

Focus on healthy nuts

In a study with over 45,000 men, there were significant reductions in CAD with omega-3 polyunsaturated fatty acids (PUFAs). Both plant-based and seafood-based omega-3s showed these effects (8). Good sources of omega-3s from plant-based sources include nuts, such as walnuts, and ground flaxseed. Of course, be cautious about consuming too many nuts, since they’re also calorically dense.

Your ultimate goal should be to become “heart attack proof,” a term used by Dr. Sanjay Gupta and reinforced by Dr. Dean Ornish. While even modest dietary changes can significantly reduce your risk, the more significant the lifestyle changes you make, the closer you will come to achieving this goal.

References:

(1) cdc.gov. (2) BMJ 2011; 343:d4488. (3) Arch Intern Med. 2004 Feb 23;164(4):370-376. (4) nutrition.org (5) NHANES 2009-2010 Data Brief No. 12. Sep 2014. (6) eatright.org. (7) Arch Intern Med. 2001 Nov 26;161(21):2573-2578. (8) Circulation. 2005 Jan 18;111(2):157-164.

Dr. David Dunaief is a speaker, author and local lifestyle medicine physician focusing on the integration of medicine, nutrition, fitness and stress management. For further information, visit www.medicalcompassmd.com or consult your personal physician.

A Jamaican fruit bat, one of two bat species Scheben studied as a part of his comparative genomic work. Photo by Brock & Sherri Fenton

By Daniel Dunaief

Popular in late October as Halloween props and the answer to trivia questions about the only flying mammals, bats may also provide clues about something far more significant.

Despite their long lives and a lifestyle that includes living in close social groups, bats tend to be resistant to viruses and cancer, which is a disease that can and does affect other mammals with a longer life span.

Armin Scheben

In recent work published in the journal Genome Biology and Evolution, scientists including postdoctoral researcher at Cold Spring Harbor Laboratory and first author Armin Scheben, CSHL Professor and Chair of the Simons Center for Quantitative Biology Adam Siepel, and CSHL Professor W. Richard McCombie explored the genetics of the Jamaican fruit bat and the Mesoamerican mustached bat.

By comparing the complete genomes for these bats and 13 others to other mammals, including mice, dogs, horses, pigs and humans, these scientists discovered key differences in several genes.

The lower copy number of interferon alpha and higher number of interferon omega, which are inflammatory protein-coding genes, may explain a bat’s resistance to viruses. As for cancer, they discovered that bat genomes have six DNA repair and 33 tumor suppressor genes that show signs of genetic changes.

These differences offer potential future targets for research and, down the road, therapeutic work.

“In the case of bats, we were really interested in the immune system and cancer resistance traits,” said Scheben. “We lined up those genomes with other mammals that didn’t have these traits” to compare them.

Scheben described the work as a “jumping off point for experimental validation that can test whether what we think is true: that having more omega than alpha will develop a more potent anti-viral response.”

Follow up studies

This study provides valuable potential targets that could help explain a bat’s immunological superpowers that will require further studies.

“This work gives us strong hints as to which genes are involved, but fully understanding the molecular biology will require more work” explained Siepel.

In Siepel’s lab, where Scheben has been conducting his postdoctoral research since 2019, he is using human cell lines to see whether adding genetic bat elements makes them more effective in fighting off viral infections and cancer. He plans to do more of this work with mice, testing whether these bat variants help convey the same advantages in live mice.

Armin Scheben won the German Academic International Network Science Slam competition with his presentation on bat genomics.

Siepel and Scheben have discussed improving the comparative analysis by collecting information across bats and other mammals of tissue-specific gene expression and epigenetic marks which would help reveal changes not only in the content of DNA, but also in how genes are being turned on and off in different cell types and tissues. That could allow them to focus more directly on key genes to test in mice or other systems.

Scheben has been collaborating with CSHL Professor Alea Mills, whose lab has “excellent capabilities for doing genome editing in mice,” Scheben said.

Scheben’s PhD thesis advisor at the University of Western Australia, Dave Edwards described his former lab member’s work as “exciting.”

Edwards, who is Director of the UWA Centre for Applied Bioinformatics in the School of Biological Sciences, suggested that Scheben stood out for his “ability to strike up successful collaborations” as well as his willingness to mentor other trainees.

Other possible explanations

While these genetic differences could reveal a molecular biological mechanism that explains the bat’s enviable ability to stave off infections and cancer, researchers have proposed other ways the bat might have developed these virus and cancer fighting assets.

When a bat flies, it raises its body temperature. Viruses likely prefer a normal body temperature to operate optimally. 

Bats are “getting fevers without getting infections,” Scheben said.

Additionally, flight increases the creation of reactive oxygen species, which the bat needs to control on an ongoing basis.

At the same time, bats produce fewer inflammatory cytokines, which helps prevent them from having a runaway immune reaction. Some researchers have hypothesized that bats clear reactive oxygen species more effectively than humans.

A ‘eureka’ moment

The process of puzzling together all the pieces of DNA into individual chromosomes took considerable time and effort.

A Mesoamerican mustached bat, one of two bat species Scheben studied as a part of his comparative genomic work. Photo by Brock & Sherri Fenton

Scheben spent over 280,000 CPU hours chewing through thousands of genes in dozens of species on the CSHL supercomputer called Elzar, named for the chef from the cartoon “Futurama.” Such an effort would have taken eight years on a modern day personal computer.

During this effort, Scheben saw this “stark effect,” he said. “We had known that bats had lost some interferon alpha. What astounded me was that some bats had lost all alpha” while they had also raised interferon omega. That was the moment when he realized he found something novel and bat specific.

Scheben recognized that this finding could be one of many that lead to a better understanding of the processes that lead to cancer.

“We know that it’s unlikely that a single set of genes or a small set of genes such as we identified can fully explain the diversity of outcomes when it comes to a complex disease like cancer,” said Scheben.

A long journey

A resident of Northport, Scheben grew up in Frankfurt, Germany. He moved to London for several years, which explains his use of words like “chuffed” to describe the excitement he felt when he received a postdoctoral research offer at Cold Spring Harbor Laboratory.

When he was young, Scheben was interested in science despite the fact that classes were challenging for him.

“I was pretty poor in math and biology, but I liked doing it,” he said.

Outside of work, Scheben enjoys baking dense, whole wheat German-style bread, which he consumes with cheese or with apple, pear and nuts, and also hiking.

As for his work, which includes collaborating with CSHL Professor Rob Martienssen to study the genomes of plants like maize that make them resilient amid challenging environmental conditions, Scheben suggested it was the “best time to be alive and be a biologist” because of the combination of new data and the computational ability to study and analyze it.

Scheben recognized that graduate students in the future may scoff at this study, as they might be able to compare a wider range of mammalian genomes in a shorter amount of time.

Such a study could include mammals like naked mole rats, whales and elephants, which also have low cancer incidence and long lifespans.

METRO photo

By Daniel Dunaief

Daniel Dunaief

My wife and I used to say “the recording is always on.”

It was our code words to each other to be careful about what we said and did in front of our children, particularly when, as many parents know, we might not want our children to act or speak in the same way we might be tempted to in the moment.

Our children have an incredible ability to monitor everything we do, even when they don’t appear to be paying any attention to us. Sometimes, they actively choose the opposite because our choices annoyed or frustrated them.

If, as many of us say and believe, we want our children to be better than we are, we wish them well, wait and watch, hoping their happiness, success and achievements far exceed our own.

Perhaps such reaction formation is what brings grandparents and grandchildren together, causing various characteristics to skip a generation, as two opposites create the same.

Aside from things like weekly routines, an emphasis (or not) on achievements like community service, or performance in sports or music, parents recognize that we are role models.

In the movie “42” about trailblazer Jackie Robinson, the first African-American man to play in Major League Baseball, a father shouts racial epithets at Robinson, leading his conflicted son to ponder how to behave. The son echoes what his father shouts.

In that moment, Peewee Reese puts his arm around Robinson, offering his public support and quieting the hostile crowd. Reese even suggests, as a nod to the realities of today, that “Maybe tomorrow we’ll all wear number 42. That way they won’t tell us apart.”

Films are great, but we don’t live in a world where supportive music and smiling heroes remind us who we are or how we should act.

It’s up to us to decide how to be better for ourselves and for our children.

A friend recently shared a story about his daughter. A college student, she was working at an ice cream store during a fall break. A few customers came in and a man in the group asked her where she attended college.

When she told him, the man suggested that there were Muslims who attended that college and it would be easy enough to take a few of them behind the shed and get rid of them.

The man who made a joke about murder at a time of violent conflict in the Middle East and ongoing and hostile disagreements among Americans probably wasn’t thinking about his children, about my friend’s daughter, or anyone else.

Maybe he was repeating the words his father or mother said at the dinner table, after an evening of drinking or within minutes of leaving a house of worship.

Is that the person he wants to be? Is that what he would encourage his own children to believe, that people who practice other religions or have other beliefs are somehow such enemies that it’s okay to make such a comment?

We have to be better than that. Maybe the guy didn’t mean it, but even saying it suggests that he not only thought it, but that he also likely shared that idea in some context in front of his children.

Killing and hatred won’t end if we don’t hold ourselves accountable for our actions and words.

We identify ourselves in particular ways, by such factors as nationality, religion, race, among many other labels.

Those identifiers, many of which we didn’t choose but are an accident of our birth, mean that others around us are on the outside, associating with a different group.

We owe it to our children to imagine and create a better world. That starts by serving as role models and not as reflexive perpetuators of anger, hatred, or prejudice towards those we consider others.

With the world echoing the conditions from the 20th century, we should speak and act in ways that bring people together and that would make us proud if and when we heard our children making those same, or perhaps better, remarks.