Yearly Archives: 2020

Superintendent Joe Rella a his last graduation ceremony, 2019. Photo by Kyle Barr

By Kyle Barr and Monica Gleberman

Dr. Joe Rella, the beloved former Comsewogue superintendent who spent just over 25 years in the district, passed away Feb. 21, with Moloney Funeral Homes and the district confirming his death late Friday night. He was 69.

Community members flocked to social media to share their thoughts and memories about their superintendent affectionately known around the district as just “Rella.”

Comsewogue Superintendent Joe Rella with students who participated in Joe’s Day of Service. Photo from CSD

“So much of what I learned about community was through his unceasing example of what it meant to serve the place you call home,” said Kevin LaCherra, who graduated in 2009. “To bring people in, to find out what they need, to fight like hell to get it and then to pass the torch.”

Rella entered the district as a part-time music teacher, making only $28,000 in salary. He would move on to become a full-time music teacher, then the high school principal and finally, superintendent of schools, which was his final position, held for nine years.

In an interview with TBR News Media before his retirement and final graduation ceremony in 2019, Rella had likened the act of running a school district to music, all based in a learning process for both the students and for him.

“Because one thing you learn, there is no such thing as a mistake, it’s a springboard to your next part of the piece,” he said.

The district planned to decorate school buildings with blue-and-gold ribbons come Monday and make counselors available for students who may need it, current Superintendent Jennifer Quinn said Saturday. The district was closed Wednesday, Feb. 26 to allow teachers and students to attend his funeral.

Quinn had worked with Rella for 13 years. In a phone interview Saturday, the current superintendent had nothing but great things to say about her predecessor and mentor. If anything, she said Rella “did not want people to remember him sadly. He wanted them to smile and laugh. He just loved everybody.” 

Rella’s wife, Jackie, passed in 2016 following a struggle with breast cancer. The superintendent himself had been diagnosed with stage 4 bile duct cancer in 2017. Despite his sickness, he would stay on in the top position for another two years. 

Comsewogue Superintendent Joe Rella congratulates a member of the class of 2016 during graduation June 23, 2016. File photo by Bob Savage

It was that dedication, even in the face of sickness and loss, that built up so much trust between him and the community over the years. Quinn said he was humble, always the one to take the blame if plans didn’t work out, but he was always ready to heap praise on others.

“He made everyone important,” she said. “He never shied away from a tough problem and tried to make everything better — he always did.”

Others in the district said Rella’s example pushed them to do more and to do better. Andrew Harris, a special education teacher in the high school, created Joe’s Day of Service in 2018. Named after the then-superintendent, the program asked students to do volunteer work around the school and the greater community. Students have traveled all the way to the Calverton Cemetery in both 2018 and 2019 to clean graves and plant flags.

Harris said there are hundreds of examples of Rella’s kindness, such as driving over an hour to take care of a teacher’s mother who was suffering from cancer.

“In many ways, just like they call the middle of our country the ‘flyover states,’ Port Jefferson Station used to be like a ‘drive-through town’ — people were on their way to another town as the destination,” Harris said. “That all changed with Dr. Rella’s leadership. No matter where you went, and especially as a teacher, when you say you are from Comsewogue and Port Jefferson Station, people know where you came from and the legacy. It makes us all proud to say it.”

The school board accepted Rella retirement in November 2018. He had said in previous interviews his diagnosis did not factor into his decision to retire, and it had been his and his wife’s intent to make that year his last.

“Joe and Jackie were the face of Comsewogue for many years,” said John Swenning, school board president. “Their dedication and support to our administrators, teacher, staff, parents and most importantly our students is nothing short of legendary. Dr. Rella is the Italian grandfather that every kid deserves to have. He will be missed dearly.”

School board trustee Rob DeStefano had known Rella since his sophomore year in Comsewogue high, when the to-be super had joined the district as the new music teacher. DeStefano would be elected to the board coinciding with Rella’s appointment as head of schools. One memory that cemented the famed superintendent in his mind, according to a previous column he wrote for TBR after Rella’s announced retirement, was during a jazz band concert he and his wife got up on stage and started to dance the Charleston.

Rella speaks out against standardized testing in 2015. File photo

Despite the loss, the Rella name lives on in the district, particularly in the high school courtyard, full of sunflowers, named Jackie’s Garden after his late wife. As the superintendent participated in his final high school graduation ceremony last year on June 26, students rolled out a new plaque, naming the high school auditorium the Dr. Joseph V. Rella Performing Arts Center.

His funeral, held Wednesday, Feb. 26, at St. Gerard Majella R.C. Church in Port Jefferson Station, drew huge crowds of family as well as school officials and community members.

Those same Community members and school officials gathered outside the high school Wednesday morning before the funeral. At just after 10 a.m., a hearse bearing Rella and a procession drove around the circle outside the high school, his final visit to the institution residents say he cared so deeply about. Members of both the Port Jefferson and Terryville fire departments hung a giant flag above the ground for the hearse to drive under. Residents and students held blue and yellow signs, all thanking the superintendent for his life of work and service. 

Quinn said they will be working out the details for a larger memorial sometime in the near future.

“He embodied the Comsewogue culture — pushed it and all of us forward,” said 2019 graduate Josh Fiorentino. “To say I know how he wanted to be remembered would be a lie. However, I and many others will remember him as a Warrior. The truest of them all.”

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Bethel AME Church and Higher Ground prepare to restore historic house

The Rev. David and Mary Baker-Eato House, circa 1984. File photo from Preservation Long Island

During the past 15 years, initiatives by Higher Ground Intercultural and Heritage Association  to increase protection of the district include: obtaining a Town of Brookhaven Landmark citation for Bethel African Methodist Episcopal Church in Setauket; obtaining a districtwide Endangered Site nomination by Preservation League of New York; hosting A Long Time Coming Archaeological Project; starting a benchmark Cultural Resource Survey; and registering the district on state and national registers of historic sites in November 2017. In the same year, the Old Bethel Cemetery, which belongs to Bethel AME Church, was nominated to state and national registers of historic places through the remarkable efforts of Vivian Nicholson Mueller and Simira Tobias.

The home of one of Bethel AME Church’s first pastors Photo from Preservation Long Island

In a joint collaboration to preserve historic inventory, and to expand the historical significance of the district, Bethel AME and Higher Ground are working together to restore the historic Rev. David and Mary Baker-Eato House, which is located within the historic district.

Research has indicated the house was probably built between 1900 and 1917. Recently, several grants opened a new window of opportunity to Higher Ground that boosted the restoration project. The organization recently received a $1,220 grant award from the Unitarian Universalist Fellowship at Stony Brook; a $3,000 award from New York Landmarks Conservancy which was directed to Bethel AME Church; and a $25,000 grant award from the Gerry Charitable Trust in October 2019.

With this fresh infusion of funds, the joint Eato House restoration project plans to start preliminary activities to build organizational capacity in the spring of this year, followed by planning the first stages of restoration at a later date. With sincere appreciation, Higher Ground acknowledges that the first funding to create and protect the BCALH District, between 2009 to 2015, was made possible by grants awards from The National Center for Suburban Studies at Hofstra University and The Preservation League of New York State.

While there is only little information about the origin and date the Eato House structure was built, the historically significant occupants, the Rev. David Eato and his wife Mary L. Baker-Eato, offer us an alternate view of a portion of American history. Eato was born in August 1854 in Roslyn, where many members of the Eato family remained. He was the fourth of nine children of Peter Eato and Charlotte Corse.

In the early 1840s, before Eato’s birth, his father worked as a sailor on the sloop Andrew Jackson, a merchant vessel that served shore communities in New York and New Jersey. On March 12, 1840, Capt. Jacob M. Kirby listed 21 employees, including “Peter Eato or Etoo.” Captain Kirby paid his employees with some cash but also by bartering such items as watch repair, powder and shot, watermelons, boots and trousers. In later census records, Peter Eato was listed as a laborer or farm laborer. He died of cancer Nov. 19, 1899, age 87.

David Eato was heavily handicapped during his ministry with dropsy (vascular edema). In spite of his disability, he spent his life as pastor of several small AME congregations on Long Island. Beginning in Roslyn, he spent much of his service at Mt. Olive AME Church in Elmhurst, where he dedicated a new church worth $9,000 Thanksgiving Day, 1907. In 1906, he also served the Union AME Church (later St. Mark) in Jackson Heights. In 1908, he moved to the Mount Olive AME Church in Mount (Port) Washington. He may have served both the Port Washington Church and the Setauket Church simultaneously, since there is a note about his work in Setauket in 1911 and another reference to his work as a pastor at Port Washington in 1913.

Around 1915-16, he moved to Setauket with his second wife Mary Lucinda Baker-Eato. In Port Washington June 29, 1913, Eato married Mary, who played piano and organ at the Mount Olive AME Church.

Baker-Eato was born in 1868 in South Carolina, the daughter of Oliver Baker and Catharine Buite-Baker. Catharine Baker (called Grandma Kitty by her family) was born on the Baker plantation in Troy, South Carolina. It is presumed Mary Lucinda Baker, Catherine’s only known child, was born on the Baker plantation.

Baker-Eato graduated from Allen University in Colombia, South Carolina. Allen University was established by the African Methodist Episcopal Church in Cokesbury, South Carolina, in 1870, and later moved to Columbia. She may have majored in music, since she later taught piano and organ. While she was still living in Troy, she married Robert Wydeman. Together, they had five daughters, Jessie, Katie, Josephine, Mary Louise and Frances. In 1901, Baker-Eato, her five daughters and Grandma Kitty all moved north to Port Washington. Eato-Baker worked as a cook (perhaps in a restaurant), gave music lessons, and played piano and organ in the Port Washington AME Church.

After the Eatos married in 1913, they were still living in Elmhurst in 1915 (according to the New York State census), taking care of one of her daughters from her first marriage, Katie Weidman, and granddaughter Helen Coleman. By 1917, they were living in Setauket, where the Hyde map listed David Eato’s name beside the Eato house. In 1920, the census noted that the Eato family rented a house on Locust Avenue, where they lived with Baker-Eato’s grandchildren Helen Coleman, 11, and Adolph Blake, 3.

In 1925, the census recorded David Eato, age 70, living with his wife Mary Eato, age 57; Arthur T. Blake, age 15; and Adolph J. Blake, age 8. Mary Eato bought the Eato house from R.W. Hawkins and Carrie Hawkins in 1928 and became one of several African American women who owned homes in this area.

In 1930, David Eato was not listed in the census. Mostly likely he died between 1925 and 1928, when Mary Eato purchased this house. Although sources of information about the reverend and his wife reveal the life of two individuals who left a vision and hope for their descendants, their lives are representative of the many thousands of African Americans who survived slavery in America and made their way to Long Island.

Those other lives, not recorded, represent stories lost and gone forever because of the erection and maintenance of an ages old framework of historical narrative largely unchanged in America, since the end of the 19th century. It is as though revelations of Native American and Afro-American history, their history in the Americas and throughout the world, have been intentionally buried.

Today, we are learning that a significant portion of the history of Afro-Americans in America is being revealed through scientific research and recent archaeological and anthropological discoveries. In recent years public activism, local and national preservation organizations and state and federal legislation have acted to conduct new research; to render a revised and more complete history of Afro-Americans, and fully integrate it into a more inclusive history of America. At the present time, a new coalition of 21st-century researchers have been on the forefront to revise this forgotten history, as opposed to educators and scientists that pandered to biased academia from the 17th century, lasting through most of the 20th century.

There is ample evidence that there are hundreds of Afro-American cultural sites with similar stories, such as the Eatos and their home on Christian Avenue, that give the viewer an opportunity to see history differently. When descriptions of the structure, site and occupants of historic cultural origin are joined together, they become a comprehensive story in stark revelation. They become a doorway — an entryway to the truth of a cultural legacy connected to an ancient time, 3,000 years ago. However, the complex paradigm of intractable narratives of American history that remain as a pedagogy, since post-Civil War Reconstruction is a gate still standing; gradually being broken down by people who want to know the truth.

We can begin at the gate by saying: “Christopher Columbus (Cristoforo Colombo) did not discover the Americas.” From that observation, we are thus able to see misconceptions in the cultural and racial dynamics of history; to posit arguments against the old theories; engage in conversations that realize there is an imperative to rewrite a significant portion of American history. The huge number of obscured Afro-American communities, such as the Bethel Christian Avenue, Laurel Hill Historic District, their historic inventory and structures such as the Eato House have enormous importance, not only to America’s history, but that they are integral toward a revision that transmits truth into our education systems.

Robert Lewis is the president of Higher Ground Intercultural and Heritage Association.

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Fifth-graders at St. James Elementary School in the Smithtown Central School District held a wax museum for their classmates and families Feb. 14. 

After researching a historical figure of their choice, the students dressed the role and became part of the living museum. They portrayed famous historical people, sports stars and entertainment legends. When someone “buzzed” them, the figures came to life and were able to animate themselves and give a biographical history of their character.

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Students at Thomas J. Lahey Elementary School got in the spirit of Valentine’s Day on Feb. 14.

Third-graders visited math teacher Nancy Sordi and learned to measure different ingredients, like glue and red food dye, to make Valentine’s Day slime. Some students chose to make their slime even more festive with glitter and heart-shaped confetti.

Down the hall, fourth-graders in Danielle Donohue and Jane Dayton’s class prepared Valentine’s Day care packages to send to troops overseas. Students sorted lollipops, candy bars and cookies between three boxes that will be shipped to soldiers stationed in the Middle East. Additionally, each of the students designed a Valentine’s Day card to be sent with the care packages. 

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A Hampton Inn will turn the old Huntington Town Hall into a boutique hotel. Rendering by Huntington Village Hotel Partners LLC

Developers will look to turn the old Huntington Town Hall into a Hampton Inn hotel. The $24 million proposed project by Holtsville-based Huntington Village Hotel Partners LLC would turn the more than 100-year-old former Town Hall, located at 227 Main St., into an 80-room hotel. 

The Town Hall building would be converted to the hotel’s lobby, breakfast room and gym. A 53,636-square-foot addition will be used for the guest rooms.

Rosario Cassata and George Tsunis, developers for the project, also intend to buy the property adjacent and across the street of the old government building for parking.

In addition, the project secured $2.8 million in tax breaks from the Suffolk Industrial Development Agency.

The tax breaks were awarded at a Feb. 13 Suffolk IDA meeting and include $1.8 million off property tax over a 15-year period. According to IDA documents, about 128 workers will be employed during the construction phase of the hotel. Once completed, the hotel will have 14 employees who will earn just over $39,700 per year.

Tony Catapano, executive director of the Suffolk County IDA, said he believes the hotel will bring in visitors from outside and around Long Island. 

“The historic nature [of the building] will draw people to it, there will definitely be interest from residents in Suffolk and Nassau County,” he said. 

The proximity of the hotel to the downtown area is another plus, the executive director of the agency said. 

“The hotel from downtown Huntington village is really walkable, and they’ll be able to take advantage of the local amenities,” he said. “The old Town Hall building is the eastern entrance to downtown and I think retrofitting it into a hotel will make [the entrance] beautiful.”

The IDA granted the tax incentives using a tourism exception to the state law that prohibits helping retailers. As part of the IDA’s Long Island First policy, the developers are required to buy materials from local companies and employ local construction workers.

This is not the first time a hotel has been proposed for the old Town Hall, back in 2014, the IDA backed a different project that would have cost upward of $10 million. It would have received $3 million in tax breaks over 15 years. The project ultimately failed to get off the ground.

According to IDA documents, the hotel is anticipated to open in the second quarter of 2021.

A Brit Reviews the UK’s Eventual Withdrawal from Europe

Stock photo

Part 3 of 3

By John Broven

When I started this series in March 2019, I wanted to give U.S. readers a Brit’s inside view on Brexit. The term has now become such common currency over here, rather like the Latin phrase “quid pro quo,” that all I need explain is that Brexit refers to Britain exiting the European Union, which it duly did Jan. 31 of this year. On the same date the U.S. Senate rejected further witnesses in the impeachment trial of President Donald Trump (R). It was hardly a red-letter day for western politics.

John Broven Photo by Diane Wattecamps

After publication of the first two articles, I was approached by residents of all age groups at the Stony Brook railroad station, in a deli, at a mall, in a coffee shop, at a party, even at an outdoor art show. Everyone expressed an intrigued interest in Brexit and, it’s fair to say, concern for my English home country. What on earth was going on? Why indulge in such potential self-harm?

When I left you with my June article, the United Kingdom and EU had agreed on another revised exit date, Oct. 31, but with no parliamentary majority the way forward was still far from clear. “Will there be a general election, second referendum, another EU extension or a hard no deal?” I asked.

It came to pass there was a general election Dec. 12 and a further EU extension to Jan. 31, with no second referendum or precipitous hard deal (to date). With the U.K.’s withdrawal from the EU, what happened in the interim?

A third prime minister in three years

For a start, on July 24, Boris Johnson achieved the prize he had wanted from his days as a privileged aristocratic youth at Eton College and Oxford University: the prime ministership of the U.K. After being elected as leader of the Conservative Party (also known as the Tories), he took over from the hapless Theresa May (C) who was unable to deliver on her promise to leave the EU after three years in the hot seat.

Brexit had thus claimed another victim, making Johnson the third prime minster since David Cameron (C) fell on his sword after a dismal and inept Vote Remain campaign during the June 2016 referendum.

Without a working majority, Johnson was confronted by a parliament determined to ensure that if Brexit happened there would be no hard deal. The new prime minister even tried, unsuccessfully, to suspend parliament for five weeks in an effort to stifle debate and ram through the withdrawal agreement by Oct. 31. Queen Elizabeth II was inadvertently embroiled when she dutifully signed the prorogation request of Johnson, who made the flimsy pretense of needing time to prepare for the Queen’s Speech, but the U.K. Supreme Court ruled otherwise. I suspect Her Majesty was not amused. 

There was clearly a power battle being fought between parliament and the prime minister, reminiscent of the current war of attrition between Congress and Trump. 

The generally pro-Brexit Tory Party, with its band of rabid hardliners, was armed with the 52-48 percent Voter Leave victory of the 2016 referendum. Amid calls from the Brexiters for “democracy” to be respected and with a definite all-round war weariness in the nation, it was clearly going to be difficult for the main opposition parties — Labour, Liberal Democrats, Scottish National Party and the Greens — to overturn “the will of the people.” 

At one time, the charismatic speaker of the House of Commons, John Burcow, even invoked an arcane 1604 parliamentary principle to stifle a government motion. (Think about it, that’s 16 years before the Mayflower landed on our shores.) However, the opposition could not find agreement among themselves for a unified approach, even with voting support from 21 Tory rebels. This rump included former Chancellor of Exchequer Philip Hammond, Father of the House Ken Clarke and Sir Winston Churchill’s grandson, Nicholas Soames. Incredibly these respected establishment figures were thrown out of the Tory Party in petulant retribution. You see what I mean about parliamentary drama.  

With time running out, the EU begrudgingly extended the Oct. 31 deadline to Jan. 31 after a last-minute fudged agreement with Johnson over the vexatious Irish border backstop question.

December general election

Parliament was still in deadlock, but eventually a general election was called for Dec. 12. Campaigning on a resonating “Get Brexit done” ticket, Johnson won a huge working majority of 80 seats to break the parliamentary impasse. His Conservative Party brushed aside the Labour Party and Liberal Democrats, also Nigel Farage’s Brexit Party. Labour, in its worst general election result since 1935, ignominiously saw the demolition of its “red wall” in the industrial north of England, the traditional home of socialism. The Lib-Dems, under Jo Swinson, went all out with a remain message. Yet this bright young leader couldn’t articulate on the stump the benefits of staying in Europe and she even lost her own parliamentary seat. 

The main opposition winners were the Scottish Nationalist Party, under Nicola Sturgeon, which swept Scotland. Watch out for a possible future referendum for Scotland to leave the U.K. and become a member of the EU. 

Richard Tapp, of Burgess Hill, West Sussex, added in an email, “Besides the Scottish Nationalists, the pro-EU parties in Northern Ireland also did well, at the expense of the pro-Brexit Democratic Unionist Party whose leader in Westminster lost his seat to the nationalists of Sinn Fein who campaign for a united Ireland — and so remain in the EU.” 

Johnson had targeted the disaffected, forgotten part of the nation — the provincial middle class as well as the working class — with a Trump-like populist message, just as the new prime minister had done beforehand with the referendum. The general election was a damning indictment of Jeremy Corbyn’s leadership of the Labour Party, both for his far-left policies and his “sit on the fence” approach to Brexit. 

Interestingly, there are concerns in the U.S. about the Democratic Party following the Labour/Corbyn route to self-destruction in the next election with a progressive socialist agenda. James Carville, President Bill Clinton’s (D) 1992 election-winning strategist, was particularly animated on the subject in the Financial Times and on “Morning Joe,” referring to the unelectable Corbyn by name.

Brexit is done

And so, with no obstacles in his way, Johnson “got it done” by signing a withdrawal agreement with the EU, meaning Britain officially left the union at the end of January after almost a half-century of membership. Brexit is now fully owned and controlled by the prime minister and his Conservative Party, with the background help of Dominic Cummings, the architect of the Vote Leave campaign’s victory in 2016. 

The coverage on BBC World News in Brussels revealed genuine European regret at the loss of Britain as a vital contributing member to the EU, including politicians from Poland and Sweden. Yet the expected party atmosphere in the U.K. didn’t materialize because the country was still split right down the middle — and it was raining on Farage’s celebration parade outside the Houses of Parliament. Financial Times columnist Simon Kuper had a perverse explanation for the low-keyed reaction: “On Jan. 31, many Brexiters spent their ultimate moment of triumph attacking elitist traitors instead of celebrating.” This revenge, he said, “is so much of the point of populism.” 

Those Brexit voters expecting a brand-new dawn, with a return to the glory days of the British Empire free of the EU yoke, will have to wait until at least Dec. 31 this year for all kinds of trade, security and legal negotiations to be agreed before the cord is cut. 

During this transition period the U.K. will continue in the EU’s custom union and single market, while still complying with EU rules (but without any more say in the lawmaking process in the European Parliament). Johnson has indicated there will be no extension, leading to the nightmare scenario of a possible no deal commencing Jan. 1, 2021. It will not be an easy negotiating ride.

I’m still of the view that a people’s referendum should never have been considered by Cameron on such a critical and complex matter, which will affect generations to come. His irresponsible bet was compounded by the Brexiters never explaining the downsides — and dangers — of leaving Europe, including diminished influence on the world stage. Already China is waiting in the wings.

Michael Hanna, of Hassocks, West Sussex, echoed my thoughts in an email on the night of Jan. 31: “In about two hours time Boris and his Gang will tear us out of the European Union on the say so of just 17.4 million, a mere 37 percent of the electorate. This is politically the saddest day of my life. For the last 47 years we have been members of the great European family of nations to which we should naturally belong. This has given us huge benefits which the Tory government is knowingly throwing away.”

With thanks for their on-the-spot observations to my British friends Roger Armstrong, Chris Bentley, Mike Hanna, Martin Hawkins, John Ridley and Richard Tapp. 

John Broven, a member of the TBR News Media editorial team, is an English-born resident of East Setauket, who immigrated to the United States in 1995. He has written three award-winning (American) music history books and is currently editing the first book on New York blues.

Lingbo Zhang Photo from CSHL

By Daniel Dunaief

In the span of a few months, Lingbo Zhang, a Cold Spring Harbor Laboratory fellow, has made discoveries involving two deadly blood cancers.

In September, Zhang, collaborating with researchers from Memorial Sloan Kettering Cancer Center and the National Institute of Diabetes and Digestive and Kidney Diseases, found a drug target that might eventually lead to a new treatment for myelodysplastic syndrome, which is a common form of blood cancer. The scientists published their work in the journal Science Translational Medicine.

In January, Zhang published work that analyzed the genes that are active in acute myeloid leukemia, which has a five-year survival rate of only 33 percent. 

By studying 230 genes, Zhang found that this form of blood cancer is addicted to higher concentrations of vitamin B6, creating a potential target for future therapy. The CSHL scientist published this work in the journal Cancer Cell.

“We feel humbled that we found a target” for a future AML therapy, Zhang said of his latest discovery. “My lab partners and I think one day we can potentially translate our knowledge into a real therapy. The translational part gives us the energy and encouragement to work hard.”

Indeed, Zhang explained that his work broadly focuses on blood cancer, in which he looks for questions of medical importance. With MDS, he started with the view that many patients with this disease do not respond to the typical treatment using a hormone called erythropoietin, or EPO.

Lingbo Zhang

People with MDS typically have too few red blood cells, which are made in bone marrow. The hormone EPO converts progenitor immature versions of red blood cells into the ones that function in the body. A small percentage of MDS patients, however, respond to EPO. This occurs because people with this disease have a smaller pool of progenitor cells.

Zhang and his colleagues went upstream of those progenitor cells, searching for defective processes earlier in the pathway. They found that a protein receptor, CHRM4, decreases the production of cells that might become red blood cells. 

By inhibiting that receptor, they hoped to restore the red blood cell making process. In mice that have the same blood features as human MDS, this approach worked, restoring the machinery that leads to the production of red blood cells.

With both the MDS and the leukemia studies, these discoveries might lead to a future treatment, but are not necessarily the final step between understanding molecular signals and developing treatments. These findings are transitioning from basic discoveries into the preclinical development of novel therapies, Zhang said.

For MDS, the treatment may be effective with the inhibitor itself, while for AML, it will potentially be effective as part of a therapy in combination with other treatments.

In his work on leukemia, Zhang said the research went through several phases, each of which took several months. For starters, he screened all the potential target genes. Once he performed the initial work, he conducted a validation study, exploring each gene, one by one. Finally, he worked to validate the study.

After all that work, he discovered the role that the gene that makes PDXK, the enzyme that helps cells use vitamin B6, plays in contributing to cancer. Normal, healthy cells use vitamin B6 during metabolism to produce energy and grow. As with most cancers, leukemia involves more cell division than in a healthy cell, which means that the PDXK enzyme is more active.

Scott Lowe, a collaborator on the research and former CSHL fellow who is now the chair of Cancer Biology and Genetics at Memorial Sloan Kettering, expressed surprised at the finding. “While the action of certain vitamins has previously been linked to cancer, the specific links between vitamin B6 identified here were unexpected,” he said in a press release.

A postdoctoral researcher in Zhang’s lab who has been working on the project for two years, Bo Li plans to continue this research and hopes to find a more mechanistic understanding of the discovery.

While this vitamin contributes to cancer, people with leukemia shouldn’t reduce their consumption of B6, which is necessary in healthy cells. If normal and cancer cells both need this vitamin, how could this be a target for drugs?

The difference, Zhang explained, is in the concentration of the enzyme and, as a result, the B6.

PDXK is higher in leukemia. Reducing its activity by inhibiting this activity could affect the disease.

Working with a collaborator at Memorial Sloan Kettering, Zhang is hoping to develop a better chemical compound with the right property to target the activity of this gene and enzyme.

To conduct research into different diseases and pathways, Zhang works with a group of “very talented and hard working people,” in his lab, which includes a few postdoctoral researchers, a doctoral student, a few undergraduates and a technician, bringing his lab’s staff to eight people. “We also have very good collaborators at other institutes and we are able to manage several projects in parallel,” he said.

Zhang said he likes basic and translational science. The basic science brings “beautiful new theories that identify a detail nature created.” He also feels driven to “translate some of these basic discoveries into a potential treatment,” he said. He is working with a foundation and the hospital and receives patient information from them, which encourages him to work hard to seek ways to “benefit them.”

Down the road, he hopes to understand the hierarchical process that leads from stem cells to mature blood cells. By identifying a majority of the players or the regulators, he may be able to understand the different processes involved in the course of numerous diseases.

As for his current work, Zhang is pleased with the potential translational benefit of both discoveries. “I feel very happy that we can identify a target for leukemia and MDS,” he said.

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Linda Gould Dwyer

Linda Gould Dwyer, of East Setauket, died Jan. 1. She was 71.

She was born Jan. 27, 1948, in Port Jefferson and was the daughter of Evelyn and James Gould.

Dwyer was an administrator for Ann Gordon speech pathology in Stony Brook, and in her free time she enjoyed drawing and singing. She was also considered a spiritual woman.

Left to cherish her memory are her son, Thomas; sisters, Joanne and Cari; along with other family and friends.

She was preceded in death by her husband, Kerry, and her parents.

Services were held at Bryant Funeral Home, Jan. 7 with the Rev. Barbara Rispoli officiating. Interment followed in the Oak Hill Cemetery in Stony Brook.

Arrangements were entrusted to the Bryant Funeral Home of Setauket. People can visit www.bryantfh.com to sign the online guest book.

Contributions made to the North Shore Animal League in memory of her would be appreciated.

James Autino

James Autino, of Hauppauge, died Jan. 19. He was 63.

He was born Dec. 9, 1956, in Brooklyn, and was the son of Gloria and Vincent Autino.

James was an office administrator for IBM, and in his free time he loved carpentry, guitars, baseball and spending time with his family.

Left to cherish his memory are his wife, Patricia; along with Jim’s children and grandchildren: Christine Varvaro (Jason) and grandson Liam; Diana; Jimmy (Megan), granddaughters Andi and Natalie; Dan (Courtney) and grandsons Thomas, Ryan and Danny; Jim’s stepchildren: Brian, Trisha (Mike) (Mikie and Dominic); Kevin (Danielle) (daughter Kaydence); along with many other family and friends.

Services were held at Infant Jesus R.C. Church in Port Jefferson Jan. 23. Committal services were held in private.

Arrangements were entrusted to the Bryant Funeral Home of Setauket. People can visit www.bryantfh.com to sign the online guest book.

Lenore Prizzi

Lenore Prizzi, of Setauket, died Jan. 4. She was 83.

She was born June 15, 1936, in Setauket, and was the daughter of Anna and Luciano Ardizzone.

Lenore was a homemaker.

Left to cherish her memory are her husband, Gasper; daughter, Deborah; son, Jack (Judy); grandchildren, Jackie (Nicholas), Leanne (Frederick) and Louis; along with many other family and friends.

Services were held at the Bryant Funeral Home Jan. 9. Interment followed in the Calverton National Cemetery.

Arrangements were entrusted to the Bryant Funeral Home of Setauket. People can visit www.bryantfh.com to sign the online guest book.

Contributions made to the St. Jude’s Children Hospital in memory of her would be appreciated.

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Ward Melville led by 14 points at one point, only to have East Islip rally back in the third quarter to retake the lead by two in a Class AA quarterfinal. The Patriots held off the late game surge by the Lady Redmen holding on to win it, 58-56, at home Feb. 19.

Ward Melville senior Morgan Wenzler battled in the paint leading her team in rebounds along with several put-backs to top the scoring chart with 18 points. Julia Greek, a freshman, did her damage from long distance draining three triples, a field goal and three from the charity stripe netting 14 points. Senior Sarah Bucher had a triple and five from the floor for 13, and teammate Jamie Agostino, a sophomore, banked nine.

The win propels the Patriots (No. 5 seed) to the semi-final round where they’ll square off against top seeded Northport at Centereach High School Feb. 22. Tickets can be purchased for $8 online at gofan.co/app/school/NYSPHSAAXI or purchased at the gate for $10, cash only.

Game time is 2:30 p.m.

Installation of the pre-treatment septic tank at Tom O'Dwyer's home in Strong's Neck. Photo from Tom O'Dwyer

By Perry Gershon

Suffolk County has a water crisis. We must do all we can to control our nitrogen waste to protect our drinking water, our soil, our rivers and our bays. The county and many of our towns have initiated rebate programs to encourage homeowners to install clean, nitrogen-removing septic systems. Suffolk County’s program, known as the Septic Improvement Program, or by the acronym SIP, has become a political football, and it’s the public and the environment that are the losers.

Perry Gershon. Photo from SCDC

SIP was designed to direct county payments directly to contractors, bypassing individual participants so their rebates would not be taxed as income. Suffolk County’s tax counsel delivered an opinion to the county attorney ruling that 1099 forms from SIP should go to contractors and not to consumers. This should have been the end of the story. However, Suffolk County Comptroller John Kennedy (R), while engaged in a campaign against County Executive Steve Bellone (D) during the elections last year, disagreed with the tax opinion and inquired of the IRS if county payments might be taxable to homeowners? Despite protestations from the county and Senator Chuck Schumer (D-NY), the IRS, always in need of funds, said yes, why not? The ruling was issued earlier this month. So now unsuspecting homeowners are receiving 1099 forms reporting unforeseen additional taxable personal income. What is essentially a new tax is sure to both impact those who already participate and dissuade future participants.

What can be done? Bellone and his administration are working to come up with alternative structures for the SIP program. Perhaps more can be done to clarify that transactions are between the county and the contractors to satisfy the IRS? Or perhaps an offsetting tax rebate can be legislated? Congressman Tom Suozzi (D-NY3) has written a letter to the IRS demanding they reconsider the decision. But Congressman Lee Zeldin (R-NY1) remains silent. Instead of joining Suozzi, Zeldin seems to support his fellow Republican Kennedy and once again ignores ways to save money for his constituents.

Does this surprise you? It should not, given Zeldin’s poor record historically on environmental and financial matters. Or that Zeldin has recently worked against New Yorkers on the repeal of the SALT cap and on Trump’s retaliation against the state by suspending New York applications to the Trusted Traveler program. Zeldin’s Twitter feed offers perpetual praise of the president, attacks on our governor, but not a word on the septic taxation issue. Long Island needs representatives who will work for us — who have our back when the federal government takes shots at us. Zeldin doesn’t fight for us. We have a chance in November to show him how wrong that is.

Perry Gershon is a national commentator on business, trade, policy and politics. A congressional candidate for New York’s 1st District, he holds a bachelor’s degree from Yale and a master’s in business administration from the University of California, Berkeley.