Stony Brook University

Photo courtesy of Stony Brook Medicine

Stony Brook University Hospital has appointed Jonathan M. Buscaglia, MD, FASGE, AGAF, as Chief Medical Officer, effective as of April 28. In his new role, Dr. Buscaglia will oversee all clinical operations, including the quality of care and patient safety, coordination of clinical care, development of clinical information systems and physician engagement. Reporting to Carol Gomes, CEO of Stony Brook University Hospital, Dr. Buscaglia and the entire senior executive leadership team will work collaboratively to champion the continuous improvement of patient care.

Dr. Jonathan M. Buscaglia
Photo by Jeanne Neville/Stony Brook Medicine

“The role of chief medical officer is a critical component of hospital operations and I’m delighted to welcome Dr. Buscaglia to this role,” said Hal Paz, MD, executive vice president of health sciences at Stony Brook University and chief executive officer, Stony Brook University Medicine. “I look forward to working together as he continues to build on our commitment to prioritize quality throughout the system.”

“Dr. Buscaglia brings more than 20 years of experience as a physician leader to his new role, including more than ten of those years right here at Stony Brook Medicine,” said Carol A. Gomes, MS, FACHE, CPHQ, chief executive officer for Stony Brook University Hospital. “His proven dedication to the growth of our healthcare system, and multidisciplinary approach to deliver the highest level of care, is pivotal as we continue to meet the healthcare needs of our community.”

Dr. Buscaglia earned his Bachelor of Science in Biology and Psychology from Union College. He then completed his MD at the Jacobs School of Medicine and Biomedical Sciences at the University of Buffalo. After his internal medicine residency at Montefiore Medical Center, Dr. Buscaglia completed both his gastroenterology fellowship and interventional endoscopy fellowship at the Johns Hopkins Hospital. He joined Stony Brook Medicine in 2008 as Medical Director of Endoscopy where he established quality metrics for the delivery of care in digestive diseases across several medical specialties.

In 2012, he initiated Stony Brook University Hospital’s first interventional endoscopy training program and inpatient consult service. Dr. Buscaglia was appointed Chief of the Division of Gastroenterology and Hepatology in 2016 and was elected President of the Medical Board for Stony Brook Medicine in 2021. He holds the Stony Brook University academic appointment of Professor of Medicine with tenure and is a nationally recognized expert in the areas of pancreatico-biliary disorders and quality metrics in gastrointestinal endoscopy. 

Carl Legged

Carl Lejuez has been appointed Stony Brook Univerity’s new executive vice president and provost, announced SBU President Maurie McInnis. Lejuez will be joining Stony Brook on July 1, 2022. He presently serves as provost and executive vice president for academic affairs at the University of Connecticut (UConn).

As the chief academic officer at Stony Brook, Lejuez will be responsible for oversight of the academic mission of the university, providing direct supervision for all academic units, support services and operations, including enrollment management and student success, and coordinating all academic programs. In addition, the deans and directors of the colleges, schools, libraries, centers and institutes, including those in the Health Sciences related to nonclinical matters, will report to him. He will also work collaboratively with Harold Paz, executive vice president of health sciences and CEO of Stony Brook University Medicine.

Prior to his affiliation with UConn, Lejuez served as interim provost and executive vice chancellor and dean of the College of Liberal Arts and Sciences at The University of Kansas. He was also a professor of psychology and associate dean for research for the College of Behavioral and Social Sciences at the University of Maryland, a research professor at the Warren Alpert Medical School of Brown University and an adjunct faculty member at the Yale Child Study Center in New Haven, CT.

“In Dr. Lejuez, we have a leader who comes to the table with a strong track record of experience in public higher education,” said President McInnis. “I am confident Carl will help Stony Brook University meet its ambitious goals around research and academic excellence, and will be a stalwart supporter of our students, staff and faculty. He will help us find additional ways to strategically elevate our research, scholarship and art making while raising the bar even higher for amplifying our efforts to improve student success.”

“Joining Stony Brook University offers a tremendous opportunity to build upon the university’s long-standing commitment to excellence,” said Lejuez. “As a leading Association of American Universities public research institution, Stony Brook excels in educating students, creates a supportive and inclusive working environment, attracts outstanding faculty and spearheads research that improves the world. I am excited to work with President McInnis and the university community to elevate our academic programs and celebrate the accomplishments to come.”

Lejuez holds an MA and PhD in clinical psychology from West Virginia University and earned his BA in psychology from Emory University.

 

A migration journey through a Bedouin camp in the Negev Desert (Saharan-Arabian desert), Israel (2017) – a scene that will likely be more common in many areas of the world due to increasing 21st Century droughts. Photo y Gallya Lahav
Stony Brook-led research combined social science and climate models in a paper published in International Migration Review

Drought and the potential increase in the number of droughts worldwide due to climate change remains a concern for scientists. A recent study led by Stony Brook University researchers suggests that human migration due to droughts will increase by at least 200 percent as we move through the 21st Century. Based on a series of both climate and social science modeling systems and other social science data, the study findings imply that migration may force the need to adjust sociopolitical policies to offset widespread human displacement in the future. The study is published in International Migration Review.

According to lead author Oleg Smirnov, PhD, Associate Professor in the Department of Political Science at Stony Brook University, the research team worked from an ensemble of 16 climate models to generate drought projections for rest of the 21st Century. They centered on two greenhouse gas emissions scenarios: an optimistic one consistent with the Paris Agreement, and a pessimistic one based on current use of energy and greenhouse gas emissions.

It is important to note that while the Groundswell report assesses human migration projections due to climate change by 2050 in six world regions, this study analyzes potential drought-induced human migration around the entire world for the whole century going forward.

Both Smirnov and co-author Gallya Lahav, PhD, a migration specialist and Associate Professor of Political Science at Stony Brook University, assessed the sociopolitical climates and policies in connection with the climate models. Co-authors and climate experts Minghua Zhang, PhD, of Stony Brook University’s School of Marine and Atmospheric Sciences (SoMAS), and Tingyin Xiao of Princeton University, generated global drought projections for two emissions scenarios for the period of 2008 to 2100 in order to complete the analysis.

Overall, they project there will be a massive increase in drought-induced migration in the coming years – 200 percent more based on the optimistic climate projections and as high as 500 percent more if world leaders fail to cooperate on climate change mitigation measures.

“One interesting finding is that we also identified a large group of people who will want to migrate but fail to do so as droughts cover large areas of land making possible destinations difficult to get to or inferior to their land of origin,” explains Smirnov.

The authors estimate that this segment of “immobile” people will also increase by about 200 percent in the optimistic scenario, yet almost 600 percent under the “business as usual” or pessimistic scenario.

“Our models make us not only concerned about the increasing number of environmentally displaced people that may spread across the globe, but we are equally, if not more, concerned about the large number of these ‘immobile’ persons – who may be desperate to leave but unable to do so, which may contribute to social suffering and instability,” emphasizes Smirnov.

Furthermore, “given that environmentally-induced migrants largely fall outside of international legal frameworks like the Refugee Convention which protects those fleeing war or conflict, a multi-lateral holistic policy approach is vital in this grey area,” adds, Lahav, a previous consultant to the United Nations Population Division.

Despite the scientific quest to systematically assess and predict future migratory outcomes, the researchers agree that the social science aspect of the study may have additional unknown variables and complexities when projecting because of the political aspects of migration. The authors write “we can only talk about potential migration pressures, as opposed to actual migration, since we do not know how future political responses will affect and potentially constrain future migration flows. Similarly, we do not rely on the absolute number of migrants, since these numbers are sensitive to the arbitrary modeling assumptions.”

As the researchers chart the drought-induced migration models toward the end of the 21st Century, they warn that many countries will have large numbers of migrating peoples. They state that the largest number of people displaced by drought under unmitigated change would occur in these countries: Nigeria, Egypt, China, Turkey, Algeria, Mexico, Morocco, and Venezuela. The projected largest number of immobile persons would be those in Turkey, Mexico, Morocco, Algeria, Brazil, Mali, and China.

Overall, say Smirnov and colleagues, the study findings provide solid evidence that global climate change mitigation would be less costly in terms of human suffering and economic loss from drought-induced migration than policies designed to deal with the overwhelming challenges of unmitigated climate change.

This research is funded by the National Science Foundation (NSF) under the “Cyber-Enabled Discovery and Innovation” collaborative (grant numbers 0940822 and 0940744).

 

A. Laurie Shroyer Photo by Jeanne Neville/Stony Brook University

By Daniel Dunaief

Publish or perish.

It’s the academic paradigm that defines the importance of getting great research and ideas in front of the public. Not only does publishing enable researchers to share discoveries, but it also provides additional rungs on a career ladder.

Science journals with greater impact can raise the visibility of up-and-coming researchers, helping them win more competitive grants, get papers published in other journals, and receive coveted promotions and tenure.

In a recent study led by A. Laurie Shroyer, Professor of Surgery and Vice Chair for Research at the Renaissance School of Medicine at Stony Brook University, women authors in positions considered significant — first, second or last — appeared at a rate that was below their representation in academic medical school faculty for the three top ranking medical journals.

Published in the journal PLOS ONE of 1,080 author citations from 2002 to 2019 in The Lancet, the Journal of the American Medical Association and the New England Journal of Medicine, a team of researchers determined that women were listed as senior, or last, authors 18.6 percent of the time. Meanwhile, 26.8 percent of women were first authors.

The first and last author rates for women were lower than the 37.2 percent of women full-time academic faculty members, according to Shroyer. “This is truly striking. I never in my wildest dreams thought [the publication rate for women] was this low” particularly for last authors.

Indeed, the percentages varied by journal, with the New England Journal of Medicine coming in the lowest for first authors, at 15.83 percent, and the Journal of the American Medical Association showing the highest rate, at 35.39 percent. Lancet had 29.39 percent.

In response to emailed questions about the study, officials at the New England Journal of Medicine indicated that the journal does not ask authors to self-identify.

“With a group of publishers lead by the Royal Society of Chemistry, we’re developing best practices for encouraging diversity among authors,” said Eric Rubin, M.D., PhD and Editor-in-Chief of the NEJM. “Diversity in medicine is important, and we are taking steps where we can to encourage change or highlight inequities.”

In September 2021, the NEJM published an editorial that said having more diversity among researchers is one way to help make trials more representative. Additionally, in April 2021, the NEJM published a Special Report about the diversity of the medical student body.

“We believe we must diversify our own ranks and encourage diversity at all stages of medical training,” Dr. Rubin added.

The Lancet, meanwhile, indicated that the data they collected on gender representation among their authors, peer reviewers and Editorial Advisory Board members led them to develop new strategies to improve gender representation in the editorial process, including a diversity pledge and no all-male panel policy, according to a public relations statement. All Lancet International Advisory Boards are now 50 percent women. This past March, the Lancet hosted a webinar on gender equity.

Shroyer lauded The Lancet for providing a public disclosure of their author gender profiles. The Lancet’s “positive actions are admirable,” she said..

A request for comment from the Journal of the American Medical Association was not returned by press time.

While the JAMA women first author rate did not demonstrate a statistically significant difference from the Association of American Medical Colleges, it was different, at 20.8 percent for last authors and for any significant author role, at 32.8 percent compared to 37.2 percent overall.

To be sure, Shroyer and co-author Henry Tannous, chief of Cardiothoracic Surgery Division and co-director of the Stony Brook Heart Institute, didn’t receive the kind of information that would help shed greater light on the publishing process.

Shroyer explained that it would be helpful to have journal-specific editorial office data on author specific and publication specific details for manuscripts received, reviewed and accepted.

Without access to editorial office databases, “it will not be possible to discern the potential reasons behind the lower women author publication rates,” Shroyer explained, adding that with the unknown rate of gender-based submissions, it is possible that the relative proportion of submitted articles published might not be different between men and women.

“My hope is that this publication may inspire all of these top medical journals to publish their own summary reports and to share their own editorial office databases to facilitate future research in this field,” she said.

An ongoing pattern

Shroyer began investigating the author and publication characteristics associated with multiple successful publications in top medical research journals in late 2017.

To determine if the pattern had changed over time, Shroyer and Tannous divided the publication rates into early, 2002 to 2008; mid, 2009 to 2014; and late, 2015 to 2019. Using samples from these years, Shroyer concluded that there were no differences over time.

Among other conclusions, Shroyer said women first authors less commonly published clinical trials as compared with observational study designs. Their projects were also more frequently focused on infectious disease topics. Men, on the other hand, published more work focused on cardiovascular topics.

Shroyer added that the sampling of three journals’ records does not prove a gender bias. She could only show a discrepancy in the author publication rates.

She’s an advocate for individual investigator-based identifiers that are just numbers, which would allow for a more thorough and detailed analysis of any trends in publication rates.

This research provides a call for “greater transparency and accountability” Shroyer said.

As a potential optimistic sign, Shroyer found that first/ last authors with the same gender more often published clinical trials and had higher Web of Science citation counts, compared with first authors with different genders. First authors who were the same gender as last authors also had higher multiple top medical research journal publications.

While this doesn’t necessarily point to a clear mentor benefit, Shroyer suggests this connection between women principal investigators and their research staff may create greater publishing opportunities and advancement for women in science.

“My hope is that we can find ways to help each other,” she said. “Preliminary analysis shows potential promise.”

Photo courtesy of Chris Ryon

A flag once flown outside of the post office in the former Echo area of Upper Port has been returned to Port Jefferson and now resides at the Village Center.

The flag is unique in that it contains only 46 stars. It had flown outside the Echo post office between 1908 and 1912. Chris Ryon, village historian, charted the timeline of the 46-star flag. 

“The 46-star flag came about when Oklahoma became a state in 1907,” Ryon said. “The following July Fourth in 1908 produced the 46-star flag, as stars are always added to the flag on July Fourth. In 1912, it jumped from 46 to 48 stars because two more states were added, Arizona and New Mexico. That flag lasted until Hawaii and Alaska were added in the late ‘50s.”

Before the present boundaries, “the post office was right up against the railroad tracks in Upper Port Jefferson,” Ryon said. “That area was called Echo — Echo was a racehorse and that’s what it was named after. The post office was the building on the right when you crossed over the railroad tracks into Port Jefferson Station. That building is still there, but it’s an empty building right now.”

On April 10, Lee Squires Sussman and her son Grayson Sussman Squires met with Ryon to exchange the flag. “This has been in the family and has been passed down through the generations,” Ryon said. “She decided it belonged back in Port Jefferson.” 

A journey through time

Last week, TBR News Media reached out to Lee Squires Sussman for an exclusive interview. Through our correspondence with her, which included a phone interview and an email exchange, she detailed her genealogical background and her family’s place in the local history of Port Jefferson.

“I grew up outside of Washington D.C.,” she said. “My father, Donald Fleming Squires, was the deputy director of the Smithsonian Museum of Natural History when I was a child. When I was 12, we moved back to Long Island, to Stony Brook, because my dad had decided that he really wanted to get back to his roots, and back to science, not administration.” She added that by returning to Long Island, her father sought “to give back to his home community, so he went to work for Stony Brook University.”

In 1965 Donald Squires helped found SBU’s Marine Sciences Research Center, the predecessor of today’s School of Marine and Atmospheric Sciences. A renowned marine biologist, he wrote several books investigating the waters outside of New York City and Long Island. “Interestingly enough, as a sidenote, when we moved back to Stony Brook, we moved into a rental house while we looked for a place to permanently live,” Sussman said. “That house was a house that my other great-grandfather, Harry Fleming, built in Stony Brook.” She added, “We really were going back to our roots.”

Village historian Chris Ryon, left, with Lee Squires Sussman, right, and her son Grayson Sussman Squires, middle. Photo courtesy of Chris Ryon

A family keepsake

“My great-grandfather was Charles A. Squires and he was the original owner of the flag,” Sussman said. “It flew outside the post office at Echo, New York. Following his retirement, my granduncle, Dwight Squires, took over as postmaster. When he retired, my understanding is that my great-grandfather had left it with my Uncle Dwight.” 

At some point in time, Dwight had given the flag to Sussman’s grandfather, Charles W. Squires. Charles W. held onto the flag into his mid-90s and passed it along to her father, Donald. When Donald moved to Tasmania, he gave the family artifacts to her.

“All of the pictures, the certificates, the family Bible, the flag and all of that came to me when my dad moved overseas,” Sussman said. “I’ve had [the flag] stored in my living room in a sea chest that has also been passed down through the family.” 

After years of storing the flag, she started considering what to do with this family memento. During the COVID-19 pandemic, a high school friend had referred her to Ryon. The two got in touch and agreed to meet in Port Jefferson to exchange the flag. 

“I have five Squires-related children,” Sussman said. “I discussed with the kids what to do with some of these possessions. We all agreed that the flag would be best back home where it could be viewed. It really was just a matter of finding the right time to get out to Long Island and get it to Chris so that he can display it for Port Jefferson.”

Squires legacy

At around the time when Sussman began having children, she and her father took up a deep interest in the Squires family history. Her father contacted Tiger Gardiner, author of “The South Fork Squires, Long Island, New York.”

“I would say her life’s work was the genealogy of the Squires family,” Sussman said. “She documents the Squires from really early on in Long Island. When my dad left me all of the photographs and items when he went overseas, that’s when I started getting involved in the Squires family research. It was very easy because I had all of the stuff.”

Sussman described the pride of continuing this Squires tradition, documenting and sharing her genealogy for future generations. When asked how she would like the Squires to be remembered, she said for their hard work, altruism and outlook on education, which she said were central to their system of values.

“The values that the Squires family brought to me were that public service and hard work are the foundations for success,” she said. “There were times when members of my family had money and there were times when members of my family lost all their money. When money was tight, they offered help and shelter to people who were less fortunate.”

Sussman also recalled the renovations made to her grandfather’s house to accommodate and shelter the needy, adding, “During the Depression, the attic had been made into two apartments and the basement had been made into two other apartments where people who were less fortunate lived. Those values really sunk in for all of us and they’re very clearly part of what made my family members click.”

Civic engagement and public service also mattered deeply. “They were very involved in their community and they also never quit exploring,” she said. “Those are things that are a gift to any community, beyond philanthropic gifts — a sense of pride in your local surroundings and a willingness to help.”

Sussman said her family members were acutely aware of the significance of education and passed down this value to their offspring.

“History is so much bigger than us all. It doesn’t do anyone any good to leave it in a box in the house.” — Lee Squires Sussman

Photo courtesy of Chris Ryon

“There was a sign that was printed in my great-grandfather’s printing shop in Echo that we had a copy of in our house,” she said. “I gave one to Chris. It says ‘We study to please,’ which was an old-fashioned way of saying the more modern ‘we aim to please.’” Interpreting the meaning of this sign to her, she said, “To me this was always an indicator of how important study was to my family.”

Today, the Squires family flag hangs inside the Village Center. Reflecting upon her joy in seeing the flag once again on display for the residents of Port Jefferson, Sussman said, “History is so much bigger than us all. It doesn’t do anyone any good to leave it in a box in the house. This makes me incredibly happy. I’ve shed more tears over the pictures of that flag hanging in the Village Center than I can believe. It makes me incredibly happy to see it back home.”

The Stony Brook University community had Planet Earth on their minds all last week.

Earthstock 2022 took place on campus and virtually from April 18 to April 22. The student-focused event included lectures, panels, demonstrations, educational events and more.

The mission was to focus on the need to understand issues such as climate change and rising seas as well as the need to develop clean, renewable and energy and to comprehend how humans affect earth from damaging practices to ways to nurture the environment.

Speakers included Erica Cirino, author of “Thicker than Water: The Quest for Solutions to the Plastic Crisis” and Suffolk County Legislator Kara Hahn (D-Setauket).

“Earthstock is a week-long, campus-wide tradition that celebrates Earth Day and raises awareness about climate change and sustainability,” said Richard Gatteau, vice president for student affairs. “On Friday, April 22, the Stony Brook campus was full of excitement as environmental organizations and clubs, student groups, and members of the community participated in the Earthstock Festival. It was great to see students, faculty and staff together once again celebrating this annual campus tradition with an earth-friendly inspirational message.”

In addition to educational displays and exhibits, Friday’s activities included live music, rubber duck races and a Green Pledge, where students promise to make a commitment to improve and sustain the natural world and resources around me.

To end the week-long celebration, the SBU police department partnered with Student Engagement and Activities to host the sixth annual Spring Fest. The afternoon activities provided an opportunity for students and campus police to enjoy field games, snacks and music together.

SBU’s police officer Joseph Bica said it was a great day for the police department. 

“It was a great day for our police department,” he said. “Our officers conversed, played games and got to know our students while everyone enjoyed themselves.”

 

Kevin Reed. Photo courtesy of Stony Brook University

By Daniel Dunaief

Rain, rain go away, come again some other day.

The days of wishing rain away have long since passed, amid the reality of a wetter world, particularly during hurricanes in the North Atlantic.

In a recent study published in the journal Nature Communications, Kevin Reed, Associate Professor and Associate Dean of Research at the School of Marine and Atmospheric Sciences at Stony Brook University, compared how wet the hurricanes that tore through the North Atlantic in 2020 would have been prior to the Industrial Revolution and global warming.

Reed determined that these storms had 10 percent more rain than they would have if they occurred in 1850, before the release of fossil fuels and greenhouse gases that have increased the average temperature on the planet by one degree Celsius.

The study is a “wake up call to the fact that hurricane seasons have changed and will continue to change,” said Reed. More warming means more rainfall. That, he added, is important when planners consider making improvements to infrastructure and providing natural barriers to flooding.

While 10 percent may not seem like an enormous amount of rain on a day of light drizzle and small puddles, it represents significant rain amid torrential downpours. That much additional rain can be half an inch or more of rain, said Reed. Much of the year, Long Island may not get half an inch a day, on top of an already extreme event, he added.

“It could be the difference between certain infrastructure failing, a basement flooding” and other water-generated problems, he said. The range of increased rain during hurricanes in 2020 due to global warming were as low as 5 percent and as high as 15 percent.

While policy makers have been urging countries to reach the Paris Climate Accord’s goal of limiting global warming to 2 degrees Celsius above the temperature from 1850, the pre-Industrial Revolution, studies like this suggest that the world such as it is today has already experienced the effects of warming.

“This is another data point for understanding that climate change is a not only a challenge for the future,” Reed said. It’s not this “end of the century problem that we have time to figure out. The Earth has already warmed by over 1 degrees” which is changing the hurricane season and is also impacting other severe weather events, like the heatwave in the Pacific Northwest in 2021. That heatwave killed over 100 people in the state of Washington.

Even being successful in limiting the increase to 2 degrees will create further increases in rainfall from hurricanes, Reed added. As with any global warming research, this study may also get pushback from groups skeptical of the impact of fossil fuel use and more carbon dioxide in the atmosphere.

Reed contends that this research is one of numerous studies that have come to similar conclusions about the impact of climate change on weather patterns, including hurricanes.

“Researchers from around the world are finding similar signals,” Reed said. “This is one example that is consistent with dozens of other work that has found similar results.”

Amid more warming, hurricane seasons have already changed, which is a trend that will continue, he predicted.

Even on a shorter-term scale, Hurricane Sandy, which devastated the Northeast with heavy rain, wind and flooding, would likely have had more rainfall if the same conditions existed just eight years later, Reed added.

Reed was pleased that Nature Communications shared the paper with its diverse scientific and public policy audience.

“The general community feels like this type of research is important enough to a broad set of [society]” to appear in a high-profile journal, he said. “This shows, to some extent, the fact that the community and society at large [appreciates] that trying to understand the impact of climate change on our weather is important well beyond the domain of scientists like myself, who focus on hurricanes.”

Indeed, this kind of analysis and modeling could and should inform public policy that affects planning for the growth and resilience of infrastructure.

Study origins

The researchers involved in this study decided to compare how the 2020 season would have looked during cooler temperatures fairly quickly after the season ended.

The 2020 season was the most active on record, with 30 named storms generating heavy rains, storm surges and winds. The total damage from those storms was estimated at about $40 billion.

While the global surface temperature has increased 1 degree Celsius since 1850, sea surface temperatures in the North Atlantic basin have risen 0.4 to 0.9 degrees Celsius during the 2020 season.

Reed and his co-authors took some time to discuss the best analysis to use. It took them about four months to put the data together and run over 2,500 model simulations.

“This is a much more computationally intensive project than previous work,” Reed said. The most important variables that the scientists altered were temperature and moisture.

As for the next steps, Reed said he would continue to refine the methodology to explore other impacts of climate change on the intensity of storms, their trajectory, and their speed.

Reed suggested considering the 10 percent increase in rain caused by global warming during hurricanes through another perspective. “If you walked into your boss’s office tomorrow and your boss said, ‘I want to give you a 10 percent raise,’ you’d be ecstatic,” he said. “That’s a significant amount.”

Ecstatic, however, isn’t how commuters, homeowners, and business leaders feel when more even more rain comes amid a soaking storm.

Mehdi Damaghi. Photo from Stony Brook Hospital

By Daniel Dunaief

Do the birds on the Galapagos Islands, with their unique coloration, differently shaped beaks and specific nesting places, have anything to do with the cancer cells that alter the course of human lives?

For Mehdi Damaghi, Assistant Professor in the Department of Pathology at the Renaissance School of Medicine at Stony Brook University, the answer is a resounding, “Yes.”

Damaghi uses the same principles of evolutionary biology to understand how cancer, which resides within human genes, works to adapt, as it tries to win the battle to survive.

“What we try to understand is the Darwinian principals of cancer,” said Damaghi. Cancer “adapts and reprograms themselves” to their environment to survive.

Damaghi, who arrived at Stony Brook four months ago from Moffitt Cancer Center, plans to address numerous questions related to cancer. He recently received a $4 million grant from the Physical Science in Oncology program (PSON) through the National Institutes of Health/ National Cancer Institute. Working with cancer biologists, clinicians, and computational scientists, he plans to define and understand cancer’s fitness.

“We are trying to study the core evolution of cancer cells and the normal stroma around them,” said Damaghi. “We are looking at the evolution of the tumor and some of the host cells.”

Cancer biologists are trying to build mathematical and theoretical models to explore the playbook cancer uses when confronted with threats, either in the form of a body’s natural defenses against it or from therapies against which it can, and often does, develop resistance.

Treating cancer could involve using adaptive therapy, which could enable people to control and live with cancer longer, Damaghi suggested.

In studying cancer’s phenotype, or the way the disease is expressed and survives, he hopes to understand factors in the microenvironment. Many cancers, he reasons, become more problematic as people age. Indeed, centuries ago, cancer wasn’t as prevalent as it is today in part because life expectancy was shorter.

Damaghi also has an evolutionary model to explore metastasis, in which cancer spreads from one organ or system to other parts of the body. He is looking at the earliest stages of breast cancer, to see what factors some of these cancers need or take from the environment that enables them not only to develop into breast cancer, but also to spread to other systems.

Through the microenvironment, he is looking for biomarkers that might signal a potential tumor development and metastasis long before a person shows signs of an aggressive form of the disease.

“We look at the tumor as a part of a whole ecosystem that can have different niches and habitats,” he said. “Some can be hypoxic and oxidative, and others can be like a desert on Earth, where not much grows and then cancer evolves.”

Damaghi challenges cells in a culture or organoids, which are miniature, three-dimensional live models of human cells, with different microenvironmental conditions to see how they respond. He exposes them to hormones, immune cells, and hypoxic conditions.

“We try to understand what is the adaptation mechanism of cancer to this new microenvironment and how can we push them back to the normal phenotype,” he said.

Like other scientists, Damaghi has demonstrated that many of these cancer cells use sugar. Removing sugar caused some of the cancer to die.

Increasing the survival for patients could involve knowing what kinds of micro-environments cancer uses and in what order. Deprived of sugars, some cancers might turn to amino acids, dairy or other sources of food and energy.

Damaghi thinks researchers and, eventually, doctors, will have to approach cancer as a system, which might have a patient-specific fingerprint that can indicate the resources the disease is using and the progression through its various diseased stages.

Choosing Stony Brook

Damaghi appreciates the depth of talent in cancer sciences at Stony Brook University. He cited the work of Laufer Center Director Ken Dill and Cancer Center Director Yusuf Hannun. He also suggested that the Pathology Department, headed by Ken Shroyer, was “very strong.”

For their part, leaders at Stony Brook were pleased to welcome, and collaborate with, Damaghi. Hannun suggested Stony Brook recruited Damaghi because his research “bridges what we do in breast cancer and informatics.”

Shroyer, meanwhile, has already started collaborating with Damaghi and wrote that his new colleague’s focus on breast cancer “overlaps with my focus on pancreatic cancer.”

To conduct his research, Damaghi plans to look at cells in combination by using digital pathology, which can help reveal tumor ecosystems and niches.

He also appreciated the work of Joel Saltz, the Founding Chair in the Department of Biomedical Informatics. “In the fight against cancer, we all need to unite against this nasty disease,” Damaghi said. “From looking at it at different angles, we can understand it first and then design a plan to defeat it.”

Originally from Tehran, Iran, Damaghi is the oldest of five brothers. He said his parents encouraged them to explore their curiosity.

Damaghi, whose wife Narges and two daughters Elissa and Emilia are still in Tampa and hope to join him before long, has hit the ground running at Stony Brook, where he has hired three postdoctoral researchers, a lab manager, four PhD students, two master’s candidates, and three undergraduates.

Damaghi is inspired to conduct cancer research in part because of losses in his family. Two grandparents died from cancer, his aunt has breast cancer, and his cousin, who had cancer when he was 16, fought through the disease and is a survivor for 20 years.

Damaghi bicycles and plays sports including soccer. He also enjoys cooking and said his guests appreciate his Persian kebobs.

As for his arrival in Stony Brook, he said it was “the best option for me. It’s a great package and has everything I need.”

Heather Lynch

As part of its Ecology and Climate Change lecture series, the Suffolk County Vanderbilt Museum, 180 Little Neck Road, Centerport will welcome Stony Brook University’s Heather Lynch for a presentation titled Mapping Penguins with Satellites, Drones and Other Technologies in the Charles and Helen Reichert Planetarium on April 14 at 7 p.m.

In Mapping Penguins, with Satellites, Drones, and Other Technologies, Professor Lynch will share insights from her innovative research into the population dynamics of penguins on the Antarctic Peninsula. To better understand rises and falls in this population due to climate change, tourism, and fishing, Lynch marries traditional field work with a range of technologically sophisticated methods including satellite remote sensing, drone imaging, and advanced computational models.

“Penguin populations have been changing rapidly over the last 40 years,” says Lynch. “But understanding why those changes have occurred and what we might expect for the future is a surprisingly difficult challenge. [In this lecture,] I’ll discuss the threats facing Antarctic penguins and how scientists are bringing together new technology, artificial intelligence, and advanced predictive modeling to help guide policymakers in their work to protect one of the world’s last remaining wildernesses.”

Dr. Heather J. Lynch is the Institute for Advanced Computational Sciences Endowed Chair for Ecology & Evolution at Stony Brook University. She earned a B.A. in Physics from Princeton University, an M.A. in Physics from Harvard University, and a Ph.D. in Organismal and Evolutionary Biology from Harvard. She is also a National Geographic Explorer and past winner of the Blavatnik Award for Young Scientists.

Join Lynch as she shares her insight and research. $6 per person, members free. To register, visit www.vanderbiltmuseum.org.

Photo from Stony Brook Athletics

The Stony Brook baseball team entered the day down a game in its weekend set with Hartford on April 2. They finished the day with a pair of wins and a series victory, winning 9-5 and 7-5 to sweep Saturday’s double dip at Dunkin’ Donuts Park.

Shane Paradine finished the day 4-for-7, hitting .571 with a pair of doubles and a home run, leading the Seawolves in all three categories. Colton Book earned the win in game number one, throwing two scoreless in relief while striking out three. Devin Sharkey received the win in game two, a 2.1 inning relief effort.

The big blow for Stony Brook in the opener was a four-run ninth in a seven-inning contest, as Matt Brown-Eiring’s fielder’s choice allowed the go-ahead run to score. He would then score on an error by the third baseman that plated two.

In game two, the Seawolves scored in four of the seven frames, including a pair of runs in three innings. A RBI groundout and wild pitch gave Stony Brook the lead in the fifth before a two-run double in the sixth from Evan Giordano gave the Seawolves much-needed insurance.

“I’m very proud of the guys. The last two weekends, we’ve dropped that first game but we have been able to lock back in and battle back to win the series. Today specifically… it is not easy to sweep doubleheaders but we were able to be physically and mentally tough. We had some guys sick and then some guys get hurt but everybody stepped up and we were able to get the win,” said head coach Matt Senk. ‘Today was a total team effort and I couldn’t be more proud of our team.”

The team returns home for a three-game set with UAlbany. First pitch on Friday is slated for 3 p.m., at Joe Nathan Field.