Arts & Entertainment

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Reviewed by Jeffrey Sanzel

Author Sarah Beth Durst

Like many sisters, Even and Odd shared many things:

            Their bedroom.

            Their closet.

            Six pairs of flip-flops.

            Use of the living-room TV.

            And … magic.

This is the intriguing premise of the gifted, award-winning Sara Beth Durst’s young adult novel, Even and Odd. Sisters Emma and Olivia Berry live in Stony Haven, Connecticut, having moved from the magic land of Firoth. The siblings’ powers manifest on alternate days. Thus, Emma’s nickname is Even, and Oliva’s is Odd.

As they grew, the girls took separate paths. Even has passionately embraced her training and is studying for her level five exams for the Academy of Magic; she wants nothing more than to enter the magic world as a hero. Odd’s interests are grounded in the “real” world; she spends her free time working at an animal shelter and sees her sorcery as a burden.

Durst is a consummate world builder. Her nearly two dozen books contain original mythologies, complete with unique and imaginative rules, histories, and limitations. (Three of her previous, very different novels were reviewed in this paper:  The Stone Girl, in May 2018; The Deepest Blue, in June 2019; and The Bone Maker, in May 2021). With Even and Odd, she has created a universe where the known overlaps with the enchanted. And while books about wizards cannot help but recall a bespectacled boy with a lightning scar, Durst’s current offering—with its wry, contemporary wit and easy charm—echoes Peter Beagle’s The Last Unicorn and Piers Anthony’s Xanth series. She writes with a smart sense of humor, penning characters larger than life but wholly relatable. As in her previous works, her dialogue is crisp and honest and always rings true.

The Berry family runs a border shop, “close to the gateway between worlds,” serving the magical community when its members are in the mundane world. In addition to supplies, it is a source of information. For example, visitors “from Firoth could ask basic questions, such as ‘What is an airplane, and is it going to eat me?” The local gateway is behind Fratelli’s Express Bagel, owned by a wizard who looks like “a carb-and-cream-cheese-bearing Santa Claus.”

A normal day immediately shifts when it appears that “magic [is] on the fritz.” Even is briefly stuck as a skunk when she is not able to reverse a transformation. While investigating the gateway, Even and Odd become trapped in Firoth. Teamed up with an energetic young unicorn traveling under the name Jeremy (real name “Shimmerglow”), they confront the villainous Lady Vell, who is draining the magic for nefarious purposes.

The unleashed turmoil has caused shifting geography, with homes landing in dangerous locations, stalked by creatures displaced from their habitats. The author subtly offers a portrait of refugees seeking haven and even a hint of vigilante justice as the population begins to question the ability of the Academy of Magic to cut through its bureaucracy and deal with the dire situation.

The book contains a wide range of unusual beings: Haughty elves, friendly centaurs conducting research, flower fairies that sting, mermaids that screech, and a curmudgeonly but helpful goblin are among the denizens.

While the action is brisk and the adventure is always engaging, Durst’s ability to balance the magical realm with true family dynamics elevates the novel. Even and Odd are close but clash. “For me to be surprised,” quips Odd, “you need not to be predictable!” They seek their parents’ approval and yet yearn for independence. The author wisely chooses for the children to hope that the adults can fix the situation (so often eschewed in literature for young people).

Durst also delves into the doubts that plague Even. She frets over the upcoming magic test:

I have to be ready [] not taking [the exam] would feel like saying she wasn’t as good as kids her age who had magic every day. Maybe even like saying I’ll never be as good as them […] It would be admitting that the little voice of doubt that nagged at her was right, that practicing every other day wasn’t ever going to be enough, and she’d never be ready to be a hero.

Once in Firoth, Even and Odd learn starling facts about their origins. They face a surprising revelation that gives an understanding of the history of the unheard of split magic. This leads to further introspection but does not deter them from entering danger for the greater good.

Even and Odd is a wonderful book about and filled with enchantment. Durst deals with misguided and false assumptions about self, but also the ability to learn and grow. The story’s heart celebrates inherently different sisters who are bonded by love. Even and Odd embraces the normal and fantastic and weaves a shared magic all its own.

Award-winning author Sarah Beth Durst lives in Stony Brook with her husband, her children, and her ill-mannered cat. Pick up a copy of Even and Odd online at www.amazon.com or www.barnesandnoble.com.  For more information, visit sarahbethdurst.com.

Unveiling of the Jennie Melville garden. Photo from WMHO

The Ward Melville Heritage Organization (WMHO) has announced that the garden on the Jennie Melville Village Green in Stony Brook Village has been unveiled, thanks to PSEG Long Island and the Three Village Chamber of Commerce. The garden was originally planted in honor of Jennie Melville in 1948 by the Three Village Garden Club, which she founded. The Three Village Chamber of Commerce was the recipient of a $2,300 Beautification Grant funded by PSEG Long Island. The Chamber selected the Jennie Melville Village Green garden to receive a restoration including various plants, shrubs and flowers.

“PSEG Long Island is pleased to support the efforts of Three Village Chamber of Commerce to create this lovely garden in its shopping district,” said John Keating, manager of Economic and Community Development at PSEG Long Island. “The PSEG Long Island Beautification grant was crafted to help local businesses in downtowns and shopping areas that struggled through the pandemic. We are proud to fund this project that will help increase foot traffic to the area and enhance the shopping experience for everyone who visits.”

Pictured from left,  Jonathan Kornreich, Town of Brookhaven Councilmemeber; Mary Van Tuyl, Trustee, WMHO; Michael Ardolino, Board Member, Three Village Chamber of Commerce; Jane Taylor, Executive Director, Three Village Chamber of Commerce; Bill Faulk, Regional Public Affairs Manager, PSEG Long Island; John Keating, Manager of Economic and Community Development, PSEG Long Island; Dr. Richard Rugen, Chairman, WMHO; Charles Lefkowitz, President, Three Village Chamber of Commerce; Gloria Rocchio, President, WMHO; Carmine Inserra, Board Member, Three Village Chamber of Commerce; Nicole Sarno, Board Member, Three Village Chamber of Commerce; Kathleen Mich, WMHO Trustee; and Charles Napoli, Trustee, WMHO.

The Ward Melville Heritage Organization is a 501(c)(3) not-for-profit corporation founded in 1939 by businessman and philanthropist Ward Melville. Inspired by his legacy to preserve historic and environmentally sensitive properties, the WMHO continues to protect and interpret these Long Island treasures. The organization creates interdisciplinary educational and cultural experiences that integrate history, art, theater, music, science, and technology for all ages. The organization owns and manages properties deeded to it by Ward Melville, including the Brewster House (c. 1665), the Thompson House (c. 1709), the Stony Brook Grist Mill (c.1751), which are listed on the state and national register for historic places, the Dr. Erwin Ernst Marine Conservation Center, the pristine 88-acre wetlands preserve at West Meadow, the 11-acre T. Bayles Minuse Mill Pond and adjacent park, two-acre Upper Pond, and the two-acre Jennie Melville Village Green. To learn more about the WMHO, visit www.wmho.org or call (631) 751-2244

Above, The Parkview at Fountaingate Gardens. Photo from Gurwin
Certificate of occupancy for The Parkview marks milestone

Gurwin Healthcare System has officially opened The Parkview, the largest residential building of the new Fountaingate Gardens independent living complex on Gurwin’s 36-acre Commack campus, with the delivery of the certificate of occupancy in August. 

Fountaingate Gardens. Photo from Gurwin

The $115 million,129-luxury apartment Life Plan Community is a unique concept in senior living, the newest on Long Island, and the final piece in Gurwin’s senior living offering. More than 50 community members have already moved into their one- and two-bedroom apartment homes in the community. The first building, The Terraces, opened for occupancy in May. 

“With The Parkview now officially open, our vision of a Life Plan Community on the Gurwin campus has finally come to fruition,” said Stuart B. Almer, President and Chief Executive Officer of Gurwin Healthcare System. “We are now able to offer Long Islanders a way to truly age in place with peace of mind, knowing that priority access to assisted living, short-term rehabilitation, long-term care, memory care, dialysis and day care is available on the same familiar campus, should higher levels of care ever be needed.”

Comprised of 102 apartment homes, The Parkview at Fountaingate Gardens features 11 floor plan options ranging from 830 sq. ft. to 1,350 sq. ft.  The Terraces consists of 27 apartments, with six floor plan options ranging from 1000 sq. ft. to 1,570 sq. ft.  Both four-story buildings are connected to the community’s 20,000+ square-foot Clubhouse which features an array of wellness-focused amenities, a heated saltwater pool, state-of-the-art fitness center, salon, library, a variety of dining venue options and more.  

“We are thrilled to be officially, fully open to welcome new members,” said Ryan Grady, Executive Director of Fountaingate Gardens. “Our team has worked hard to create a beautiful, vibrant community for active adults; it’s wonderful to see our members enjoying their beautiful new homes, forging new relationships and embracing new opportunities. Already there is a positive energy and vibe in our community — we call it the “Fountaingate Feeling!” We are pleased to be able to offer this unique retirement lifestyle to help Long Islanders live the best of their lives.”

For more information, call 631-715-2693 or visit www.FountaingateLI.org.

'Rabbit Rabbit,' colored pencil by Margaret Minardi of Northpor

Currently on view at the Heckscher Museum of Art in Huntington is the 2022 Long Island Biennial, a prestigious juried exhibition featuring works by contemporary artists from Suffolk and Nassau Counties. 

Now in its seventh edition, the Biennial presents a cross section of Long Island contemporary art. “The public will enjoy learning more about the most recent work of the Long Island’s established and emerging artists,” said The Heckscher Museum’s Curator, Dr. Karli Wurzelbacher. 

“I am especially impressed by the ways in which many of the artists engaged with the concerns of our time, from social justice, to health, to ecology; and appreciate those who brought new approaches to traditional materials and techniques,” she said. 

This year’s exhibit encompasses a remarkable variety of media, with styles spanning abstraction to hyperrealism. “Contemporary art has been essential to the Museum since its founding more than 100 years ago,” said Heather Arnet, Executive Director & CEO. “We remain committed to sharing inspiring and thought-provoking new art with our visitors.”

The Museum received 732 artist entries, with jurors Heather Carter, Gabriela Gonzalez Dellosso, and Susan Van Scoy selecting 95 works for exhibition. 

Five exhibiting artists were designated as Award of Merit winners including Darlene Blaurock of Wantagh; Neil Leinwohl or Rockville Centre; Patricia Maurides of Sag Harbor; Margaret Minardi of Northport; and Kasmira Mohanty of Farmingville.

A diverse program of events will coincide with the exhibition. Long Island Biennial artists will be in the galleries on Oct. 16, Nov. 6, Nov. 30, Dec. 4 and Dec. 11 from 1 to 3 p.m. Meet the artists behind the artwork., free with admission.

In addition, the museum will host a Biennial Open Studios Day featuring artists Edward Acosta, Sally Edelstein, Mike Krasowitz, William Low, and Gina Mars on Oct. 16 from 11 a.m. to 4 p.m. Hop from one studio to the next for behind-the-scenes access and learn about a variety of media and techniques. Tickets to this event are $25 per person with registration required at www.heckscher.org.  

In conjunction with Hispanic Heritage Month, the museum will host a free Dual Language Family Hour with Educators Tami Wood and Karini Gaminez on Oct. 16 from 10:30 to 11:30 a.m. Children ages 5 to 10 will enjoy a family art experience in both Spanish and English. 

Visitors may also take part in an ongoing Mini Audio Tour of Long Island Biennial by artist and Biennial juror Gabriela Gonzalez Dellosso featuring an audio tour of selected works in the exhibition in both Spanish and English.

Sponsored by Robin T. Hadley and the Cunniff Family, the 2022 Long Island Biennial will be on view at the Heckscher Museum of Art, 2 Prime Ave., Huntington through Jan. 22, 2023. For more information, call 631-380-3230 or visit www.heckscher.org. 

By Heidi Sutton

Written almost 300 years ago, Beauty and the Beast is a tale as old as time. 

A classic story of love and sacrifice, a girl by the name of Belle searches to find her place among the townspeople in her village, all while dodging the advances of a self-loving brute named Gaston. When her father is taken prisoner by a monstrous beast in an enchanted castle, Belle chooses to take his place. 

The Beast is really a young prince who is trapped under the spell of an enchantress. If he can learn to love and in return find someone who will love him before all the petals on an enchanted rose wither, the curse will end. But time is running out. If the Beast does not learn his lesson soon, he and his castle staff will be doomed for all eternity. Will Belle be the one to break the spell? 

Now the  enchanting fairy tale heads to the John W. Engeman Theater in Northport to bring joy to yet another young generation in the form of Disney’s Beauty and the Beast Jr. with book by Linda Woolverton. Although an abbreviated version of the original with a running time of one and a half hours, it features all of the wonderful songs we’ve come to love by Alan Menken, Howard Ashman and Tim Rice including “Belle,” “Gaston,” “Be Our Guest,” “The Mob Song,” and everyone’s favorite, “Beauty and the Beast” sung by Mrs. Potts.

Directed by Danny Meglio with musical direction by Gina Salvia, the 15-member cast transports the audience to a French provincial town full of action, adventure, singing and dancing and does a wonderful job with special mention to Nancy Rose Fallon as the beautiful Belle and Adam Brett as the Beast who can’t control his temper. Brett really gets into character all the way down to the snarl, but is never scary. The musical touches often on Belle’s love of books and, in one of the sweetest moments in the show, she reads the story of King Arthur to her captor during their duet “Something There.” 

Terrence Bryce Sheldon as the creep Gaston and Daniel Saulle as his sidekick Lefou have the most fun roles and pull them off with ease. Michael Fasciano gives a passionate performance as Belle’s father, Maurice. 

An audience favorite, the enchanted castle staff — Jae Hughes as the candelabra Lumiere in a perfect French accent; Daniel Bishop as Cogsworth the talking clock; Suzanne Mason as Mrs. Potts the teapot; Jillian Sharpe as Babette the feather duster; Lacey Cornell as Madame de la Grande Bouche the wardrobe; and the adorable teacup Chip (a dual role played by Sophie Achee and London Delvecchio) — are visually stunning thanks to costume designer Laura McGauley who also produces the iconic yellow gown for Belle.

As choreographer, Danielle Alliotta also deserves kudos for the big dance numbers including “Gaston” and “Be Our Guest.”

A screen in the back of the stage is used to depict the different scenes of the show including the different rooms in the Beast’s castle — a nice touch — and the actors walk through the aisles often, keeping the children at the edge of their seats.

The Engeman has gone all out on this production and it shows. Catch a performance before the last petal falls.

The John W. Engeman Theater, 250 Main St., Northport presents Disney’s Beauty and the Beast Jr. through Oct. 30. Light-up roses may be purchased before the show and during intermission and costumes are encouraged. All seats are $20. For more information or to order, call 631-261-2900 or visit www.engeman theater.com.

 

'Jewish Noir II'

Reviewed by Jeffrey Sanzel

Pinpointing “noir” is challenging. Generally, explanations include terms such as “tough,” “cynical,” “dangerous” and “bleak.” However, these words could also apply to a range of works. This crime genre, which leans towards the dark and pessimistic, has an alchemical combination that defies a narrow definition. While often associated with hardboiled detective fiction (Dashiell Hammett, Raymond Chandler, Mickey Spillane), this is not necessarily an accurate association. Conceptually, “noir” focuses on flawed individuals who are often morally questionable or corrupt. Greed, lust, and jealousy mix with societal alienation resulting in situations from which the characters cannot extricate themselves.  

In any case, defining “noir” is not essential to appreciate the exceptional Jewish Noir II (PM Press), subtitled “Tales of Crime and Other Dark Deeds.” Edited by Kenneth Wishnia and Chantelle Aimée Osman, the collection of twenty-three compelling, sharp, and haunting tales encompasses an eclectic and page-turning mix. 

As indicated by the title, the over-arching element is Judaism. But the editors offer a range of perspectives, from religious to cultural. Some stories feature Jewish identity at their core; in others, the elements remain peripheral. In an age steeped in fear and a global rise in antisemitism, many of these short pieces — subtly and directly — address the toxicity embroiled therein. Osman indicates in the introduction, “What I do know is that this anthology is important. And the stories in this book apply to everyone.”

“Taking Names” (Steven Wishnia) uses the anniversary of the Triangle Shirtwaist Factory Fire as a framing device to highlight “corruption [as] the most truly diverse aspect of New York City politics.” Like many of the stories, the language is rich and distinct: “The spokesperson for the Laborers, a skinny guy who looked like he’d lifted more textbooks than cinderblocks …” Antisemitic backlash from a reporter’s story results in a tragic and violent turn. (Later in the volume, “Triangle” (Rabbi Ilene Schneider) uses the tragedy in a wholly different and perfectly unsettling tale of an Angel of Death nurse.)

“Sanctuary” (Doug Allyn) focuses on the horrifying impact of a newly graduated medical student and the liberation of Buchenwald. A granddaughter inherits a necklace and a packet of blood-covered documents in “The Cost of Something Priceless” (Elizabeth Zelvin). With the traditional noir edge, “Only a fool can expect the cost of acquiring treasure to be paid in full. Blood has a tendency to leak and go on leaking. So do reputation and deceit.” The story of twin generational treachery concludes with a sharp stinger of a final line. The brief but potent “The Black and White Cookie”(Jeff Markowitz) takes on segregation.

The book deals with Jewish people worldwide — even as far as Trinidad and China. Violence is consistently present, both casual and deliberate. Humor flows liberally throughout, often to create an illusion quickly shattered with a deft plot twist. “Wishboned” (Jill D. Block), with its mix of fantasy and Philip Roth, deftly skewers the bar mitzvah sphere: “That was his cue, once again, that paying for a bar mitzvah is like buying a brand new sports car and driving it straight off a cliff.”

“The Shabbes Goy” (Craig Faustus Buck) is one of the book’s truly noir entries. The Jewish elements weave tautly into a narrative of plotting femme fatales and an abusive husband. “To Catch a Ganef” (Lizzie Skurnick) blends Alfred Hitchcock Presents and O. Henry in a smartly multicultural story. “Paying the Ferrymen” (E.J. Wagner), an account of a wronged wife, also feels like an ode to that 1950s series. “Inheritance” (Terry Shames) leans into a Ladies in Retirement tone, with a nursing home setting and vengeful relatives. 

Drawing on biblical sources, “Brother’s Keeper” (Eileen Rendahl) presents a private investigator and a moral dilemma utilizing the Cain and Abel story as both a parallel and mirror image. In contrast, “The Almost Sisters” (Ellen Kirschman) contains a more ethnic reflection: “If there is a gene for pessimism it will be in Jewish blood. I heard it a million times, keynehore, don’t relax, don’t get too happy, something bad is coming.”  

“Crossover” (Zoe Quinton) broods on conversion and a suspicious mikvah death, the permeating darkness in the water giving a sense of unease.

One of the most unusual entries is editor Kenneth Wishnia’s “Bride of Torches,” a bloody account of tribal battles. While the vivid tale reaches back into ancient history, its unique voice helps fit in with this modern anthology. Equally remarkable is “The Just Men of Bennett Avenue” (A.J. Sidransky), a mystical procedural drama.

“The Hanukkah Killer” (Robin Hemley) balances the portrait of a murderer — “eyes that, if they were windows to his soul, you would have wanted nailed shut” — with the vivid portrait of an old neighborhood, with its family illness, dysfunction, and poverty.

The closing story, “Hunter” (Jen Conley), follows a therapist struggling with a threatening and most likely sociopathic patient. The details are striking and disturbing — the eeriness of a burning cigarette suggesting an ominous watcher — and contrast brilliantly with the social issue — a community’s reaction to the encroachment of Orthodox families. The story’s final line is appropriately chilling and the perfect coda to this collection.

While Jewish Noir II takes mild liberties with the definition, this is a minor quibble in this amazing collection of tightly written, powerful, and must-read stories. Pick up a copy online at Amazon.com or BarnesandNoble.com. 

In conjunction with the book, Emma S. Clark Memorial Library, 120 Main St., Setauket will host Stories Light and Dark: An Evening of Jewish Noir on Thursday, Oct. 13 from 7 to 8:30 p.m. Join Kenneth Wishnia and other contributors for a spirited discussion of the diverse themes in the Jewish Noir II anthology. Copies of the book will be available for sale at the event at a discount, plus a bonus story collection offered free with each purchase. To register, call 631-941-4080

Caroline Mota Fernandes Photo by Jonas Nascimento Conde

By Daniel Dunaief

Fungal infections represent a significant health risk for some patients, killing about 1.5 million people globally each year. Doctors struggle to provide medical help for some of these patients, especially those whose weakened immune systems offer insufficient protection against developing pathogens.

Invasive fungal infections, which people typically contract by inhaling them as spores, account for about half of all AIDS-related deaths.

Maurizio del Poeta, Distinguished Professor at the Renaissance School of Medicine at Stony Brook University, has been studying ways to boost the body’s defenses against these potentially deadly infections, even among people with weakened immunities.

Recently, Caroline Mota Fernandes, a postdoctoral researcher in del Poeta’s lab, published research in the journal mBIO, a publication of the American Society for Microbiology, that demonstrated that a heat-killed, mutated version of the fungus Aspergillus conveyed protection in an animal model of an immunocompromised individual.

“The biggest news is that we can simply use the ‘autoclaved’ mutated version,” explained del Poeta in an email. “This version cannot be more dead!”

An autoclave is like a scientific oven: it raises the temperature or pressure. In this case, it can kill the mutated fungus, leaving only the mutated signal that primes the immune system.

The mutated and heat-killed version of the fungus, however, still provided full protection in a condition in a model of a weakened immune system.

“That means this formulation is highly stable and resistant to heat degradation,” del Poeta added.

Del Poeta’s lab had conducted similar research with another fungus called Cryptococcus.

By demonstrating that this approach also works with Aspergillus, del Poeta said the result “validates the cryptococcal vaccine (after all, it uses a mutant of the homolog gene, Sg11 in Crypto and SglA in Aspergillus.”

It also shows that protection exists under an additional type of immunodepression that is different from the one used in the cryptococcal vaccine.

The encouraging results, while in the preliminary stages, are relevant not only for immunocompromised people in general, but also for those who have been battling Covid, as Aspergillus was the cause of death for many patients during the worst of the pandemic.

Homologous genes

Del Poeta’s lab has focused on genes that catalyze the breakdown of steryl glucosides, which scientists have also studied in the context of plants. Crops attacked by various fungi become less productive, which increases the need to understand and disrupt these pathways.

“Folks working with plants started observing that these molecules had some kind of immunomodulatory property,” said Fernandes. “That’s where the idea of this steryl glucosides, which also is medicating fungal virulence, came from.”

The mutation Fernandes studied removed the sterylglucosidase gene sglA. Without the enzyme that breaks up the steryl glucose, the fungus had less hypha, which are necessary for the growth of the fungus. The mutation also changed the cell wall polysaccharides. Mice vaccinated with this heat-killed mutation had a one hundred percent survival rate in response to exposure to the live fungus.

“What was a very great achievement of our work was getting 100 percent protection,” said Fernandes. For immunocompromised people for whom a live attenuated fungus might threaten their health, the effectiveness of the heat-killed mutation proved especially promising.

In the experiment, she administered the vaccine 30 days before exposure, while providing boosters as often as every 10 days.

Fernandes, who started her post doctoral research in del Poeta’s lab in 2018, said several questions remain. “After this study, we are going to try to characterize exactly how this strain induces the immunity and protection to a secondary challenge of Aspergillus,” she said. Dr. Veronica Brauer, another post doctoral researcher in del Poeta’s lab, is conducting this research.

At this point, it’s unclear how long protection against a fungal infection might last.

“For us to estimate the duration of the protection, we have to have a more specific understanding of which immune components are involved in the response,” said Fernandes.

As of now, the mice vaccinated with the mutated and heat-killed fungus had no off target effects for up to 75 days after vaccination.

Fernandes is also working to characterize the mechanism of action of a new class of antifungal drugs previously identified by the lab, called acylhydrazones. She hopes to identify a new virulence protein in Cryptococcus as well.

Collaboration origins

Fernandes, who was born and raised in Rio de Janeiro, Brazil, first worked in del Poeta’s lab in 2013, while she was conducting her PhD research at Federal University of Rio de Janeiro. She was studying antifungal peptides and explained to the Brazilian government why coming to Stony Brook would contribute to her research.

Fernandes started studying fungi when she was in her second year of college at Federal University of Rio de Janeiro.

The daughter of two chemists, Fernandes said she grew up in a house in which she had pH strips, which she used to test the acidity of shampoo, water and anything else she could test. She also entered numerous science fairs.

Fernandes met her husband Jonas Conde, who is a virologist at Stony Brook University and who has studied Covid-19, when they were in nearby labs during their PhD research.

Residents of Port Jefferson, Fernandes and Conde have a four-month-old son named Lucas.

Having a child “motivates me to be better in my work and to set an example for him to be committed in doing some good for other people,” Fernandes said.

Del Poeta described Fernandes as being “extremely effective” in managing her time and has “extraordinary motivation.” He appreciates her commitment to her work, which is evident in the extra papers she reads.

Fernandes appreciates being a part of del Poeta’s lab. She described him as an “amazing” researcher and supervisor and said being a part of his group is “an honor.”

Del Poeta said Fernandes will continue to make mutants for additional fungi, including Mucorales and Rhizopous, for which antifungal therapy is not particularly effective.

Del Poeta added that the urgency of this work remains high. With several other Stony Brook faculty, he has submitted grants to study Sgl1 as a vaccine and antifungal target.

“Imagine [making] a drug that not only can treat the primary infection, but, by doing so, can potentially prevent the recurrence of a secondary infection?” he asked rhetorically. “Exciting!”

Paint Port Pink, Mather Hospital’s annual month-long breast cancer community awareness outreach, kicked off Oct. 1 with the lighting of pink lights by community partners in Port Jefferson, Port Jefferson Station, and surrounding communities. Lamp posts along Main Street in Port Jefferson are aglow with pink lights, along with the Theatre Three marquee and many store windows.

Paint Port Pink’s goal is to raise awareness about breast cancer, encourage annual mammograms, and bring the community together to fight this disease.

A pink pumpkin by Kathleen Fusaro.

Breast cancer is the most common cancer in women in the U.S., except for skin cancers, representing about 30 percent (or one in three) of all new female cancers each year. It is the second leading cause of cancer deaths for women in the U.S. after lung cancer, according to the American Cancer Society. Every two minutes someone is newly diagnosed with invasive breast cancer (Breast Cancer Research Foundation).Only one in three women over 40 have an annual mammogram. 

Paint Port Pink will feature a special HealthyU webinar on Women’s Health on Tuesday, Oct. 11 at noon. Three physicians will talk about breast cancer, menopause, and mental health during the pandemic. Register at matherhospital.org/healthyu 

Oct. 14 is “Wear Pink Day” and everyone — and their pets — are encouraged to get their pink on to raise awareness. Post photos on social media with #paintportpink and send them to [email protected] to be posted on our Facebook page.

Decorate your business window for a chance to win tickets to a 2023 concert at Jones Beach. Send photos of your window by Oct. 20 to [email protected]

The event’s popular “Pink Your Pumpkin” contest returns and encourages everyone to get creative with their pumpkins for a cause. Photos should be emailed to [email protected] by Oct. 24 and posted on social media with #paintportpink. The winner will be chosen Oct. 25 and will receive a $100 gift card. 

Paint Port Pink community sponsors include New York Cancer & Blood Specialists, Lippencott Financial Group, Riverhead Toyota, and Accelerated Services Inc., Po’ Boy Brewery , Tuscany Gourmet Market, Bohemia Garden Center, Brookhaven Expeditors, C. Tech Collections,  Michael R. Sceiford  Financial Advisor/ Edward Jones, PAP Landscape and Design, Inc., Precision Lawn Irrigation, and Swim King Pools and Patios.

A full calendar of events and a list of Paint Port Pink community partners offering promotions to benefit The Fortunato Breast Health Center is available at www.paintportpink.org. Call 631-476-2723

From despair to hope: A breast cancer survivor’s story

By Jennifer Van Trettner

Jennifer Van Trettner

It was late Friday morning on a cool December day when my phone rang. It was the (Fortunato) Breast Center calling about my routine mammogram that I had two days prior. I took a deep breath and hesitantly answered the phone. Marianne, the nurse on the other end, introduced herself and told me in a kind, warm voice that the doctor saw something of concern on my imaging and asked if I could come in for a biopsy within the hour. I said yes before I even had time to exhale.

I drove to the Breast Center alone. All sorts of thoughts were running through my head. Shortly after arrival, I was escorted to the sonogram area by a friendly woman and was given a warm gown. I undressed, wrapped myself in the warm, pink gown, and sat in the waiting room. 

A few minutes later, I was called into the sonogram room. The technician, whom I had met on several occasions, was lovely. The doctor was the same one who did my last biopsy. She explained to me that six tissue samples would be taken from my left breast. 

On Tuesday, December 21, 2021, the Breast Center called. I felt my heart plummet into my stomach and knew my life was about to change forever. As if in slow motion, I answered the call. If I close my eyes, I can still hear Marianne’s voice saying they received my biopsy results and asking if I could come to the breast center that day. This time I didn’t want to go alone. My mother-in-law, a breast cancer survivor, went with me (my mother, also a breast cancer survivor, lives in Georgia). 

With masks on, we walked into the Breast Center and were immediately brought into the office. It was warm and inviting. The doctor came in, introduced herself to my mother-in-law and sat in a chair at the end of the desk, almost directly in front of me. I could feel my eyes welling with tears.

I was told my biopsy was positive for IDC (Invasive Ductal Carcinoma) breast cancer. It was stage 1, estrogen positive, and Her2+. Relatively speaking, it was a good scenario. Marianne held up a pretty, clear box of pearls ranging from 2mm up to 20mm. She took out a 10mm pearl, placed it in my hand and told me this was the approximate size of my cancer. As I held the pearl in my hand, I thought what a nice, kind, warm, and non-scary way to confirm a woman’s fear.

Marianne, having years of my personal information in front of her, explained how she already called and made appointments with the doctors I would need to see. 

I called my mom from the office. I really needed to hear her voice. I asked her to get dad and put the phone on speaker. Telling my parents, from hundreds of miles away, their eldest daughter had breast cancer was not easy. I found myself standing at the entrance to a new path, and I wasn’t quite sure how to take the first step. One thing I knew for sure was that I wouldn’t have to take the first step alone. After hanging up with my parents, I was escorted to have an MRI. A few hours later and completely emotionally exhausted, we headed home.

On the morning of December 30, 2021, I saw my surgeon who would remove the cancer and sentinel lymph nodes. In the afternoon I saw the oncologist who had done genetic testing on me two years earlier (all of which were negative). He explained my cancer and the treatment it would require. I would need 12 weeks of chemotherapy and Herceptin infusions once a week for three to seven hours followed by an additional 13 Herceptin infusions every three weeks. Once those were finished (anticipated finish date: 2/8/23), I would need 10 years of Tamoxifen. The same evening, I had a PET scan. Thankfully, there were no surprises.

I started to tell family, friends, and colleagues of my diagnosis. I was immediately touched by the outpouring of love and concern. Helpful gifts began to arrive. The best gifts of all were the arrival of my parents a few days prior to surgery. 

My surgery at Mather Hospital was scheduled for January 25, 2022, which at the time of diagnosis felt like years away. In the back of my head was a little voice wondering if my aggressive cancer would get larger and spread during those weeks of waiting. I started an online journal and invited those closest to me to follow. 

The warrior in me began to take charge of my treatment, familiarize myself with my cancer, mastectomy options, implant options, and read from cover to cover the amazing book the breast center gave me at time of diagnosis. I reviewed all possible side effects. After that I never looked back. 

On the day of surgery, I arrived at the hospital anxious, nervous, and prayed that waking up after surgery was God’s will. I worried about what would happen to my husband and adult children if I didn’t. 

I  was brought into a large operating room. I fell asleep within seconds of speaking to the anesthesiologist and woke up seven hours later in recovery. The nurses were wonderful. Two of my former students, now nurses working the night shift, visited me bringing with them my favorite sweets, Swedish fish. Seeing familiar, friendly faces that night made my heart happy

Since my surgery, life has had many challenges. The first two weeks post-surgery I spent on the couch with my parents taking care of all household things while my husband went to work. April 14th, I tested positive for COVID, which set me back a week in treatment. Thankfully my oncologist prescribed an antiviral. It helped with my recovery and got me back on track with the infusions.

Treatments began with inserting the IV needle, blood work, Herceptin, a bag of Zofran, a bag of Benadryl and lastly chemo. By treatment six, my hair was very thin, so I decided to take control and shave what was left. The last day of chemo was May 21st, and on May 28th, I began my tri-weekly Herceptin infusions.

Throughout this journey, I have posted consistently on social media. I was born a teacher, and as such I felt it important to share my journey with anyone who wanted to follow. I believe it’s important for me to show my strengths and weaknesses, to be real, raw, and honest. This is a club no one wants to join. In the United States breast cancer affects 1 in 8 women, and on Long Island it’s 1 in 6. I had a support system like no other to help me get through this.

Schedule a mammogram today!

The Fortunato Breast Health Center at Mather Hospital, 75 North Country Road, Port Jefferson uses state-of-the-art breast imaging technology in a warm and assuring environment with a commitment to giving you personalized breast healthcare. 

Their staff of professionals provides 3D mammograms and offers individualized follow-up care, education for patients, families, and the community, as well as breast cancer support groups. 

Their Breast Center radiologists are specialists who only read breast imaging studies and look back as far as possible at your history of breast images for any subtle changes or abnormalities to provide the most accurate reading.

The Breast Health Center has also partnered with the Suffolk Cancer Services Program (CSP) to provide free breast cancer screenings to individuals who qualify. The CSP provides breast cancer screenings to women age 40 and older without health insurance in Suffolk. If any follow-up testing is needed, the CSP will provide those tests too. If cancer is found, CSP will help enroll people who are eligible in the NYS Medicaid Cancer Treatment Program for full Medicaid coverage during treatment. 

To find out if you are eligible for free screenings or to schedule your annual mammogram, call 631-476-2771. 

All photos courtesy of Mather Hospital.

 

The American Cancer Society recommends women 45-54 get annual screenings. METRO photo
New research on bisphosphonates helps clarify their role in prevention

By David Dunaief, M.D.

Dr. David Dunaief

Breast cancer is the most common cancer diagnosed in U.S. women. Experts estimate that 30 percent of 2022 cancer diagnoses in women will be breast cancer (1). Only 15 percent of cases occur in those who have a family history of the disease, and 85 percent of new diagnoses will be invasive breast cancer.

A primary objective of raising awareness during October is to promote screening for early detection. Screening is crucial, but it is not prevention, which is just as important. Prevention strategies should include primary prevention, preventing the disease from occurring by lowering your risk, and secondary prevention, preventing breast cancer recurrence.

Here, we will discuss current screening recommendations, along with tools to lower your risk.

What are current screening recommendations?

There is some variation in screening guidelines; experts don’t agree on age and frequency. The U.S. Preventive Services Task Force currently recommends mammograms every other year, from age 50 through age 74, with the option of beginning as early as age 40 for those with significant risk (2). These 2016 guidelines are currently undergoing a review and are pending publication.

The American College of Obstetricians and Gynecologists encourages a process of shared decision-making between patient and physician to determine age and frequency of exams, including whether to begin exams before age 50 or to continue after age 75 (3). Generally, it recommends beginning annual or biennial mammograms starting no later than 50 and continuing until age 75. 

The American Cancer Society’s physician guidelines are to offer a mammogram beginning at age 40 and recommend annual exams from 45 to 54, with biennial exams after 55 until life expectancy is less than 10 years (4).

It is important to consult with your physician to identify your risk profile and plan or revise your regular screening schedule accordingly.

When do bisphosphonates help?

Bisphosphonates, which include Fosamax (alendronate), Zometa (zoledronic acid) and Boniva (ibandronate), are used to treat osteoporosis. Do they have a role in breast cancer risk prevention? The short answer: it may help prevent recurrence but doesn’t appear to provide primary protective benefits.

In a meta-analysis involving two randomized controlled trials (RCTs), FIT and HORIZON-PFT, results showed no benefit from the use of bisphosphonates in reducing breast cancer risk (5). The study population involved 14,000 postmenopausal women from ages 55 to 89 women who had osteoporosis, but who did not have a personal history of breast cancer. In other words, bisphosphonates were being used for primary prevention.

However, it does appear that bisphosphonates have a role in preventing breast cancer recurrence. The recent SUCCESS A phase 3 trial considered the optimal time for treatment. Findings published in 2021 indicate that two years of treatment for patients with high-risk early breast cancer reduced recurrence risk as much as five years of treatment (6). This could alter the current paradigm of 3-to-five years of treatment to prevent recurrence of certain types of breast cancer, reducing incidences of troublesome side effects.

A Lancet metanalysis focused on breast cancer recurrence in distant locations, including bone, and survival outcomes did find benefits for postmenopausal women (7). A good synopsis of the research can be found at cancer.org.

What’s the role of exercise?

We know exercise is important in diseases and breast cancer is no exception. In an observational trial, exercise reduced breast cancer risk in postmenopausal women significantly (8). These women exercised moderately; they walked four hours a week over a four-year period. If they exercised previously, five to nine years ago, but not recently, no benefit was seen. The researchers stressed that it is never too late to begin exercise. Only about one-third of women get the recommended level of exercise every week: 30 minutes for five days a week. Once diagnosed with breast cancer, women tend to exercise less, not more. We need to expend as much energy and resources emphasizing exercise for prevention as we do screenings.

What about soy?

Contrary to popular belief, soy may be beneficial in reducing breast cancer risk. In a meta-analysis, those who consumed more soy saw a significant reduction in breast cancer compared to those who consumed less (9). There was a dose-response curve among three groups: high intake of >20 mg per day, moderate intake of 10 mg and low intake of <5 mg. Those in the highest group had a 29 percent reduced risk, and those in the moderate group had a 12 percent reduced risk when compared to those who consumed the least. In addition, higher soy intake has been associated with reduced recurrence and increased survival for those previously diagnosed with breast cancer (10). The benefit from soy is thought to come from isoflavones, plant-rich nutrients.

Hooray for Breast Cancer Awareness Month stressing the importance of mammography and breast self-exams. However, we need to give significantly more attention to prevention of breast cancer and its recurrence. Through potentially more soy intake, as well as a Mediterranean diet and modest exercise, we may be able to accelerate the trend toward a lower breast cancer incidence.

References: 

(1) breastcancer.org. (2) uspreventiveservicestaskforce.org. (3) acog.org. (4) cancer.org. (5) JAMA Intern Med. 2014;174(10):1550-1557. (6) JAMA Oncol. 2021;7(8):1149–1157. (7) Lancet. 2015 Jul 23. (8) Cancer Epidemiol Biomarkers Prev. 2014 Sep;23(9):1893-902. (9) Br J Cancer. 2008; 98:9-14. (10) JAMA. 2009 Dec 9; 302(22): 2437–2443.

Dr. David Dunaief is a speaker, author and local lifestyle medicine physician focusing on the integration of medicine, nutrition, fitness and stress management. For further information, visit www.medicalcompassmd.com.