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Daniel Dunaief

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From left, Sam Kleeman, Assistant Professor Tobias Janowitz, Miriam Ferrer Gonzalez and Emma Davidson. Photo by Caryn Koza/CSHL

By Daniel Dunaief

This part one of a two part series.

It’s a bit like shaking corn kernels over an open flame. At first, the kernels rustle around in the bag, making noise as they heat up, preparing for the metamorphosis.

That’s what can happen in any of the many laboratories scattered throughout Long Island, as researchers pursue their projects with support, funding and guidance from lab leaders or, in the science vernacular, principal investigators.

Sometimes, as happened recently at the benches of Cold Spring Harbor Laboratory Assistant Professor Tobias Janowitz, several projects can pop at around the same time, producing compelling results, helping advance the careers of developing scientists and leading to published papers.

PhD graduate Miriam Ferrer Gonzalez and MD/ PhD student Sam Kleeman recently published separate studies.

In an email, Janowitz suggested the work for these papers is “time consuming and requires a lot of energy.” He called the acceptance of the papers “rewarding.” 

In a two-part series, Times Beacon Record News Media will describe the research from each student. This week, the focus is on Ferrer Gonzalez. Check back next week for a profile of the work of Kleeman.

Miriam Ferrer Gonzalez

Miriam Ferrer Gonzalez. Photo by Caryn Koza/CSHL

Miriam Ferrer Gonzalez was stuck. She had two results, but couldn’t seem to figure out how to connect them. First, in a mouse model of the ketogenic diet — heavy on fats, without including carbohydrates —cancer tumors shrunk. That was the good news.

The bad news, which was even more pronounced than the good, was that this diet was not only starving the tumors, but was triggering an earlier onset of cachexia, in which bodies weaken and waste away. The cachexia overpowered the mice, causing them to die sooner than if they had a normal diet.

Ferrer, a student in residence from Spain who was conducting her research at Cold Spring Harbor Laboratory while earning her PhD at the University of Cambridge in the UK, thought the two discoveries were paradoxically uncoupled. A lower tumor burden, she reasoned, should have been beneficial.

In presenting and discussing her findings internally to the lab group, Ferrer received the kind of feedback that helped her hone in on the potential explanation.

“Finding out the mechanism by which a ketogenic diet was detrimental for both the body and the cancer was the key to explaining this uncoupling,” Ferrer explained.

The adrenal glands of mice fed a ketogenic diet were not producing the necessary amount of the hormone corticosterone to sustain survival. She validated this broken pathway when she discovered higher levels of corticosterone precursors that didn’t become functional hormones.

To test this hypothesis, she gave mice dexamethasone, which boosted their corticosterone levels. These mice had slower growing tumors and longer lives.

Ferrer recently published her paper in the journal Cell Metabolism.

To date, the literature on the ketogenic diet and cancer has been “confusing,” she said, with studies that show positive and negative effects.

“In our study, we go deeper to explain the mechanism rather than only talking about glucose-dependency of cancer cells and the use of nutritional interventions that deprive the tumor of glucose,” said Ferrer. She believed those factors are contributing to slower tumor growth, but are not solely responsible.

Thus far, there have been case studies with the ketogenic diet shrinking tumors in patients with cancer and, in particular, with glioblastoma, but no one has conducted a conclusive clinical trial on the ketogenic diet.

Researchers have reported on the beneficial effects of this diet on epilepsy and other neurological diseases, but cancer results have been inconclusive.  For the experiments in Janowitz’s lab, Ferrer and technician Emma Davidson conducted research on mouse models.

Ferrer, who is the first author on the paper, has been working with this system for about four years. Davidson, who graduated from the College of Wooster in Ohio last year and is applying to MD and MD/PhD programs, contributed to this effort for about a year.

Next steps

From left, Emma Davidson, Assistant Professor Tobias Janowitz, Sam Kleeman and Miriam Ferrer Gonzalez. Photo by Caryn Koza/CSHL

Now that she earned her PhD, Ferrer is thinking about the next steps in her career and is considering different institutions across the country. Specifically, she’s interested in eating behavior, energy homeostasis, food intake and other metabolic parameters in conditions of stress. She would also like to focus on how hormonal cycles in women affect their eating behavior.

Originally from a small city in Spain called Lleida, which is in the western part of Catalonia, Ferrer appreciated the opportunity to learn through courses and conferences at Cold Spring Harbor Laboratory.

Until she leaves the lab in the next few months, Ferrer plans to work with Davidson to prepare her to take over the project for the next year.

The follow up experiments will include pharmacologically inducing ferroptosis of cancer cells in mice fed a ketogenic diet. They hope to demonstrate that early induction of ferroptosis, or a type of programmed cell death, prevents tumor growth and prevents the tumor-induced reprogramming of the rest of the body that causes cachexia.

These experiments will involve working with mice that have smaller and earlier tumors than the ones in the published paper. In addition, they will combine a ketogenic diet, dexamethasone and a ferroptosis inducing drug, which they didn’t use in the earlier experiments.

Janowitz has partnered with Ferrer since 2018, when she conducted her master’s research at the University of Cambridge. As the most senior person in Janowitz’s lab, Ferrer has helped train many of the people who have worked in his lab. She has found mentoring rewarding and appreciates the opportunity to invest in people like Davidson.

Ferrer, who is planning a wedding in Spain in September, is a fitness and wellness fan and has taken nutrition courses. She does weight lifting and running.

Ferrer’s parents don’t have advanced educational degrees and they supported their three children in their efforts to earn their degrees.

“I wanted to be the best student for my parents,” said Ferrer, who is the middle child. She “wanted to make my parents proud.

The hand off

Emma Davidson and Miriam Gonzalez Ferrer examine an adrenal gland sample section from a cachectic mouse. Photo by Caryn Koza/CSHL

For her part, Davidson is looking forward to addressing ways to implement further treatment methods with a ketogenic diet and supplemental glucocorticoids to shrink tumors and prevent cachexia. 

Davidson appreciated how dependable Ferrer was during her time in the lab. Just as importantly, she admired how Ferrer provided a “safe area to fail.”

At one point, Davidson had taken all the cells she was planning to use to inject in mice. Ferrer reminded her to keep some in stock.

“Open lines of communication have been very beneficial to avoid more consequential failures,” Davidson said, ”as this mistake would have been.”

Davidson developed an interest in science when she took a high school class called Principles in Biological Science and Human Body Systems. When she was learning about the cardiovascular system, her grandfather had a heart attack. In speaking with doctors, Davidson acted as a family translator, using the language she had studied to understand what doctors were describing.

Like Ferrer, Davidson lives an active life. Davidson is preparing for the Jones Beach Ironman Triathlon in September, in which she’ll swim 1.2 miles, bike 56 miles and run a half marathon. She plans to train a few hours during weekdays and even more on weekends for a competition she expects could take about six hours to complete.

Davidson started training for these events with her father Mark, an independent technology and operations consultant and owner of Exoro Consulting Group.

Longer term, Davidson is interested in medicine and research. After she completes her education, she will try to balance between research and clinical work.

 

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Donald Triplett. Photo from Wikimedia Commons/ Ylevental, CC BY-SA 4.0 , via Wikimedia Commons

By Daniel Dunaief

Daniel Dunaief

At a recent national meeting of experts in his field, Matthew Lerner said the gathering paused to toast the remarkable life of Donald Triplett.

Born and raised in Forest, Mississippi, Triplett died on Thursday, June 15 at the age of 89, after a full life in which his family, his community and a medical and research field around him learned about a condition he helped various communities understand.

Triplett was different from other children growing up, and in 1943, after his parents brought him to psychiatrist Dr. Leo Kanner, he became “Case 1” for a new diagnosis called autism.

“Everything we know about autism started with what was learned from Donald,” said Lerner, associate professor in Clinical Psychology at the Stony Brook Neurosciences Institute. “I’m still confident the field would have found its way to autism,” but the interaction between Triplett and Kanner helped establish some of the parameters that define a condition that researchers estimate affects about one in 36 children today.

As with people who have other diagnoses, the reaction people have to those with autism varies.

“There are two broad threads in the history of how we’ve understood, studied and treated autism since the 1940s,” said Lerner.

In one, people consider it a lifetime disability, in which the diagnosis is limiting and stigmatizing.

In the second, people see autism as a different way of being, in which individuals have an opportunity to develop a meaningful and happy life, as was the case with Triplett.

“The idea of autism as being so different and so impairing was the prototype,” Lerner said. Triplett’s life “didn’t follow that trajectory at all. He had a life filled with community in which he felt supported and accepted.”

This second model of autism, Lerner added, is achievable in “far more cases than we may have historically assumed.”

Triplett, who worked at the Bank of Forest for 65 years and traveled the world, had unusual cognitive abilities that set him apart from neurotypical people. He could multiply two three-digit numbers rapidly without a calculator. He also could look at the side of a building and could indicate the number of bricks without counting them one by one. He had perfect pitch.

As he was growing up, he didn’t interact socially in typical ways for children his age. His parents institutionalized him for a year, where he became withdrawn and disinterested. When they brought him back to their home, he became more engaged, earning a high school and bachelor’s degree in French from Millsaps College.

“He may have been the first, but he was far, far, far from the only autistic person who ended up exceeding the horizons set for him when he was young,” Lerner said.

Lerner believed people in the autistic community, like Triplett, have something to teach others about challenging circumstances.

“Kids are going to get where they are going at their own pace,” Lerner said. Being patient and kind and taking time to meet people where they are as individuals can help people grow. Lerner suggested that “we need to be okay with the idea that what that person is going to be is themselves and the best thing we can do is create a space” for that development to occur.

People will develop when they don’t feel like they are failing because people around them are setting expectations that don’t match them or are underestimating what they can do, he added.

“It’s important to feel validated and valued” through life, Lerner said.

Parents of children from a wide range of abilities sometimes hear what their offspring will never do.

People are frequently “proven wrong” by that child in that family, he added.

As for Triplett, Lerner encouraged people to watch the movie ’In a Different Key” about the person later known as Case 1.”

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Dr. Sharon Nachman, chief of the Division of Pediatric Infectious Diseases at Stony Brook Children's Hospital. File photo from Stony Brook Medicine

With COVID-19 pandemic restrictions in the rearview mirror, residents have been returning to the open road and the open skies, visiting places and people.

In addition to packing sunscreen, bathing suits and cameras, local doctors urge people to check the vaccination status for themselves and their children, which may have lapsed.

“During COVID, many people did not keep up with their vaccines,” said Dr. Sharon Nachman, chief of the Division of Pediatric Infectious Diseases at Stony Brook Children’s Hospital. “That has led to a decrease in the amount of children who are vaccinated.”

Last week, the Centers for Disease Control and Prevention issued a health advisory to remind doctors and public health officials for international travelers to be on the lookout for cases of measles, with cases rising in the country and world.

As of June 8, the CDC has learned of 16 confirmed cases of measles across 11 jurisdictions, with 14 cases arising from international travel.

Measles, which is highly contagious and can range from relatively mild symptoms to deadly infections, can arise in developed and developing nations.

Measles can be aerosolized about 60 feet away, which means that “you could be at a train station and someone two tracks over who is coughing and sneezing” can infect people if they are not protected.

The combination of increasing travel, decreasing vaccinations and climbing levels of measles in the background creates the “perfect mixture” for a potential spread of the disease, Nachman said.

Typical first symptoms include cough, runny nose and conjunctivitis.

Conjunctivitis, which includes red, watery eyes, can be a symptom of numerous other infections.

“Many other illnesses give you red eyes,” Nachman said, adding, “Only when you start seeing a rash” do doctors typically confirm that it’s measles.

People are contagious for measles when they start to show these symptoms. Doctors, meanwhile, typically treat measles with Vitamin A, which can help ease the symptoms but is not an effective antiviral treatment.

As with illnesses like COVID, people with underlying medical conditions are at higher risk of developing more severe symptoms. Those with diabetes, hypertension, have organ transplants or have received anticancer drugs or therapies can have more problematic symptoms from measles.

In about one in 1,000 cases, measles can cause subacute sclerosing panencephalitis, or SSPE. About six to 10 years after contracting the virus, people can develop SSPE, which can lead to coma and death. 

In addition to children who need two doses of the measles vaccine, which typically is part of the measles, mumps and rubella vaccine, or MMR, doctors urge people born between 1957 and 1985 to check on their vaccination status. People born during those years typically received one dose of the vaccine. Two doses provide greater protection.

Two doses of the MMR vaccine provide 97% protection from measles. One dose offers 93% immunity, explained Dr. David Galinkin, infectious disease specialist at Port Jefferson-based St. Charles Hospital.

People born before 1957 likely had some exposure to measles, which can provide lifelong immunological protection.

Nachman also urged people to speak with their doctor about their vaccination status for measles and other potential illnesses before traveling. People are protected against measles about two weeks after they receive their vaccine.

Doctors suggested that the MMR vaccine typically causes only mild reactions, if any.

Tetanus, Lyme

In addition to MMR vaccines, doctors urged residents to check on their tetanus vaccination, which protects for 10 years.

“The last thing you want to do is look for a tetanus vaccination in an international emergency room,” Nachman added.

During the summer months, doctors also urged people to check themselves and their children, especially if they are playing outside in the grass or near bushes, for ticks.

Intermediate hosts for Lyme disease, a tick typically takes between 36 to 48 hours from the time it attaches to a human host to transmit Lyme disease.

Nachman suggested parents use a phone flashlight to search for these unwelcome parasites.



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White great pyrenese dog walking along path

By Daniel Dunaief

Daniel Dunaief

I want to talk about dog poop.

I don’t intend to describe it, compare notes, or ponder the meaning of bending over after our dogs relieve themselves to take their excrement and dump it in our garbage cans or, perhaps, to ship it to Mars so Matt Damon will have fertilizer for a crop of potatoes.

It’s the whole picking up of the steaming logs that I’d like to address.

You see, the other day, my son and I took our 95-pound dog for a walk. Yes, bigger dogs make larger and, often, smellier poops. I know because I’ve walked smaller dogs recently and am amazed at the delicate little pebbles they gingerly push out of their smaller digestive systems.

So, there we were, the three of us, on our happy stroll, with my dog smelling everything and nothing and my son and I talking about, shocker, sports!

My dog did his thing. At that point, I reflexively leaped into action, opening a small plastic bag that I turned inside out so I didn’t have to come into contact with, you know, it.

I bagged it up, the way I always do, tied the bag twice, as is also a part of the routine, and gently lay the bag near a tree, preparing, as I have for the last five years, to retrieve the bag on my return trip.

That’s when a bald, angry, younger man honked at me from his car and threw out his hands in a frustrated “are-you-kidding-me-right-now” pose.

I shrugged and kept walking because other people’s anger, particularly when I don’t feel responsible for it, isn’t about me.

But the gentleman didn’t leave well enough alone. He circled around and found my son, my dog and me, rolled down his angry window and demanded to know if I was planning to pick up the poop.

“Yes, of course,” I said. “I’ve been walking him for five years, and I pick it up every time.”

My son seemed more than a bit amused.

“Are you the dog poop police?” he asked.

“Yes,” the man in the pickup truck replied without a touch of irony.

“Can I see your badge?” my son asked.

This was heading in the wrong direction.

“I hate it when people leave their dog’s poop all over the neighborhood,” the gentleman, who was coming across as anything but gentle, said. “Are you sure you’re going to pick it up?”

“Yes,” I said. “I always do.”

“Do people leave poop everywhere?” my son asked.

“Yes, they do,” the man said.

The stare down lasted another few minutes. Why, I thought later, would I bother to bag up his poop as if it were a holiday present if I intended to leave it? Wouldn’t I continue walking, ignoring the doggy remains of his dinner?

The man drove off. No, he didn’t spin his tires. When I picked up the bag, I looked around to see if he was hiding, waiting to catch me in a dog-faced lie.

Alas, despite the numerous pickup trucks that sped by, none looked like his truck or had his scowl leaning out of the window.

We sure are an angry and confrontational society these days, aren’t we? This man took time out of his day to confront me about a bag of poop.

I guess the good news is that he’s protecting us from dog poop scofflaws. The sad part, however, is that he figured I was prepared to bag it up and leave it behind. He didn’t know me and quickly assumed the worst.

I wonder if he feels the same level of concern for, say, the wrappers people toss out of their car windows. Does he knock on car doors to ask people sitting with their engines on to turn them off so they don’t pollute the air?

Now, that’s an idea that makes sense to me. Then again, the dog poop patrol probably made sense to him. If my dog had any idea what was happening, he’d have quite a tale to share with his canine companions.

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Ali Khosronejad in front of the Santa Maria Cathedral, which is considered the first modern cathedral in Madrid.

By Daniel Dunaief

An approaching weather front brings heavy rains and a storm surge, threatening to inundate homes and businesses with dangerous water and potentially undermining critical infrastructure like bridges.

Once officials figure out the amount of water that will affect an area, they can either send out inspectors to survey the exact damage or they can use models that take time to process and analyze the likely damage.

Ali Khosronejad

Ali Khosronejad, Associate Professor in the Department of Civil Engineering at Stony Brook University, hopes to use artificial intelligence to change that.

Khosronejad recently received $550,000 from the National Science Foundation (NSF) for four years to create a high-fidelity model using artificial intelligence that will predict the flood impact on infrastructure.

The funds, which will be available starting on June 20, will support two PhD students who will work to provide an artificial intelligence-based program that can work on a single laptop at a “fraction of the cost of more advanced modeling approaches,” Khosronejad said during an interview in Madrid, Spain, where he is on sabbatical leave under a Fulbright U.S Senior Scholar Award. He is doing his Fulbright research at Universidad Carlos III de Madrid.

Stony Brook University will also provide some funding for these students, which will help defray the cost of expenses related to traveling and attending conferences and publishing papers.

In the past, Stony Brook has been “quite generous when it comes to supporting graduate students working on federally funded projects,” Khosronejad explained and he hopes that continues with this research.

Khosronejad and his students will work with about 50 different flooding and terrain scenarios, which will cover about 95 percent of extreme flooding. These 50 possibilities will cover a range of waterways, infrastructure, topography, and coastal areas. The researchers will feed data into their high fidelity supercomputing cluster simulations to train artificial intelligence to assess the likely damage from a flood.

As they build the model, Khosronejad explained that they will collect data from floods, feed them into the computer and test how well the computer predicts the kind of flooding that has can cause damage or threaten the stability of structures like bridges. Over the next four years, the team will collect data from the Departments of Transportation in California, Minnesota and New York.

Nearly six years ago, his team attempted to use algorithms available in ChatGPT for some of his AI development. Those algorithms, however, didn’t predict flood flow prediction. He tried to develop new algorithms based on convolutional neural networks. Working with CNN, he attempted to improve its capabilities by including some physics-based constraints.

“We are very enthusiastic about this,” Khosronejad said. “We do think that this opportunity can help us to open up the use of AI for other applications in fluid mechanics” in fields such as renewable energy, contaminant transport predictions in urban areas and biological flow predictions, among others.

Planners working with groups such as the California Department of Transportation could use such a program to emphasize which infrastructure might be endangered.

This analysis could highlight effective mitigation strategies. Artificial intelligence can “provide [planners and strategists] with a tool that is not that expensive, can run on a single laptop, can reproduce lots of scenarios with flooding, to figure out which infrastructure is really in danger,” Khosronejad said.

Specifically, this tool could evaluate the impact of extreme floods on bridge foundations. Floods can remove soil from around the foundation of a bridge, which can cause it to collapse. Civil engineers can strengthen bridge foundations and mitigate the effect of future floods by using riprap, which is a layer of large stones.

This kind of program can reduce the reliance on surveying after a flood, which is expensive and sometimes “logistically impossible and unsafe” to monitor areas like the foundations of bridges, Khosronejad said. He plans to build into the AI program an awareness of the changing climate, so that predictions using it in three or five years can provide an accurate reflection of future conditions.

“Floods are getting more and more extreme” he said. “We realize that floods we feed into the program during training will be different” from the ones that will cause damage in subsequent years.

Floods that had a return period of every 100 years are now happening much more frequently. In one or two decades, such a flood might occur every 10 years.

Adding updated data can allow practitioners to make adjustments to the AI program a decade down the road, he suggested. He and his team will add data every year, which will create a more versatile model.

What it can’t do

While the AI programs will predict the damage to infrastructure from floods, they will not address storm or flood predictions.

“Those are different models, based on the movement of clouds” and other variables, Khosronejad said. “This doesn’t do that: if you give the program a range of flood magnitudes, it will tell you what will happen.”

High fidelity models currently exist that can do what Khosronejad is proposing, although those models require hundreds of CPUs to run for five months. Khosronejad has developed his own in house high fidelity model that is capable of making similar predictions. He has tested it to examine various infrastructures and used it to study various flooding events. These models are expensive, which is why he’s trying to replace them with AI to reduce the cost while maintaining fidelity.

AI, on the other hand, can run on a single CPU and may be able to provide the same result, which will allow people to plan ahead before it happens. The NSF approved the single principal investigator concept two months ago.

Khosronejad has worked with Fotis Sotiropoulos, former Dean of the College of Engineering and Applied Sciences at Stony Brook and current Provost at Virginia Commonwealth University, on this and other projects.

The two have bi-weekly discussions over the weekend to discuss various projects.

Sotiropoulos was “very happy” when Khosronejad told him he received the funds. Although he’s not a part of the project, Sotiropoulos will “provide inputs.”

Sotiropoulos has “deep insights” into fluid mechanics. “When you have him on your side, it always pays off,” Khosronejad said.

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Allison McComiskey, chair of the Environmental & Climate Sciences Department at Brookhaven National Laboratory

By Daniel Dunaief

Daniel Dunaief

The wildfires last week in Quebec, Canada, that brought an orange haze, smoke and record pollution to New York were not only disconcerting, but also were something of a reality check.

These raging fires occurred earlier than normal and, with a so-called cut-off low in Maine acting like a bumper in a pinball game driving the smoke down along the eastern seaboard, created hazardous air quality conditions from New York through Virginia.

“There’s a real concern about this intensity, the size of the fire, happening this early in the season,” said Allison McComiskey, chair of the Environmental & Climate Sciences Department at Brookhaven National Laboratory. “Typically, wildfire season starts later in the summer and extends through the fall. If we’re going to be having wildfires of this size this early in the season and it continues, [there will be] much more of an impact on people in terms of air quality, health, and well being.”

Dry conditions caused by climate change intensified the severity of these fires, making them more difficult to extinguish and increasing the amount of particulates that can cause lung and other health problems thrown into the air.

“Wildfire season is getting longer,” said Dr. Mahdieh Danesh Yazdi, an air pollution expert and environmental epidemiologist from Stony Brook’s University’s program in Public Health. These fires are “spread because we have drier conditions, the vegetation is dry, we have droughts. Those require long-term solutions of trying to tackle climate change on a fundamental level.”

The intensity of the smoke and the cancelation of events like the Yankees and Phillies games has raised awareness of the downwind dangers from wildfires.

“This is like our Hurricane Sandy from an air quality perspective,” said Brian Colle, division head in Atmospheric Sciences at the School of Marine and Atmospheric Sciences at Stony Brook University. 

Scientists urged a multi-level approach to tackle a wildfire problem that they believe will become increasingly dangerous for human health.

Forest management, including controlled burns, would reduce the available fuel for fires started by natural causes such as lightning.

“Forest management may be one approach,” said Dr. Danesh Yazdi. That alone, however, won’t solve the threat from wildfires amid higher temperatures and more frequent droughts, she added.

McComiskey added that researchers are “certain” that wildfires are going to increase in the future due to climate change and suggested that these events ratchet up the need for getting better predictive models about what these fires will mean for human health and the climate.

The heavy smoke that descended on New York, which some health officials described as creating conditions for those who spent hours outdoors that are akin to smoking several cigarettes, is “a wake up call that we need policies” to deal with the conditions that create these fires, McComiskey said.

The increase by a “fraction of a degree in temperature is really not the point,” McComiskey added. “We need to decarbonize our economy and we need to move toward addressing the bigger causes of climate change.”

A wildfire occurring earlier in the year with smoke filled with particulates could raise awareness and attention to the dangers from such events.

“Having this kind of thing happen in the East Coast through New York and [Washington] DC, as opposed to where we typically think of bad wildfire happening out west, in Washington State and the Rocky Mountains, might help in terms of the awareness and urgency to take some action,” McComiskey added.

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Canadian wildfire smoke reduced the amount of sunlight reaching the ground over Long Island. Photo by Terry Ballard from Wikimedia Commons

Brian Colle saw it coming, but the word didn’t get out quickly enough to capture the extent of the incoming smoke.

Dr. Jeffrey Wheeler, director of the emergency room at St. Charles Hospital in Port Jefferson. File photo from St. Charles Hospital

The smoke from raging wildfires in Quebec, Canada, last week looked like a “blob out of a movie” coming down from the north, said Colle, head of the atmospheric sciences division at Stony Brook University’s School of Marine and Atmospheric Sciences. As the morning progressed, Colle estimated the chance of the smoke arriving in New York and Long Island was “80 to 90 percent.”

Colle, among other scientists, saw the event unfolding and was disappointed at the speed with which the public learned information about the smoke, which contained particulate matter that could affect human health.

“There’s a false expectation in my personal view that social media is the savior in all this,” Colle said. The Stony Brook scientist urged developing a faster and more effective mechanism to create a more aggressive communication channel for air quality threats.

Scientists and doctors suggested smoke from wildfires, which could become more commonplace amid a warming climate, could create physical and mental health problems.

Physical risks

People in “some of the extremes of ages” are at risk when smoke filled with particulates enters an area, said Dr. Jeffrey Wheeler, director of the emergency room at St. Charles Hospital in Port Jefferson. People with cardiac conditions or chronic or advanced lung disease are “very much at risk.”

Dr. Robert Schwaner, medical director of the Department of Emergency Medicine and chief of the Division of Toxicology at Stony Brook University Hospital. Photo from Stony Brook University

Dr. Robert Schwaner, medical director of the Department of Emergency Medicine and chief of the Division of Toxicology at Stony Brook University Hospital, believed the health effects of wildfire smoke could “trickle down for about a week” after the smoke was so thick that it reduced the amount of sunlight reaching the ground.

Amid smoky conditions, people who take medicine for their heart or lungs need to be “very adherent to their medication regimen,” Schwaner said.

Physical symptoms that can crop up after such an event could include wheezing, coughing, chest tightness or breathing difficulties, particularly for people who struggle with asthma or chronic obstructive pulmonary disease.

When patients come to Schwaner with these breathing problems, he asks them if what they are experiencing is “typical of previous exacerbations.” He follows up with questions about what has helped them in the past.

Schwaner is concerned about patients who have had lung damage from COVID-related illness.

The level of vulnerability of those patients, particularly amid future wildfires or air quality events, will “play out over the next couple of years,” he said. Should those who had lung damage from COVID develop symptoms, that population might “need to stay in contact with their physicians.”

It’s unclear whether vulnerabilities from COVID could cause problems for a few years or longer, doctors suggested, although it was worth monitoring to protect the population’s health amid threats from wildfire smoke.

Local doctors were also concerned about symptoms related to eye irritations.

Schwaner doesn’t believe HEPA filters or other air cleansing measures are necessary for the entire population.

People with chronic respiratory illness, however, would benefit from removing particulates from the air, he added.

Wildfire particulates

Dr. Mahdieh Danesh Yazdi, an air pollution expert and environmental epidemiologist from Stony Brook University’s Program in Public Health. Photo from Stony Brook University

Area physicians suggested the particulates from wildfires could be even more problematic than those generated from industrial sources.

Burning biomass releases a range of toxic species into the air, said Dr. Mahdieh Danesh Yazdi, an air pollution expert and environmental epidemiologist from Stony Brook University’s Program in Public Health.

The U.S. Environmental Protection Agency has done a “fairly decent job” of regulating industrial pollution over the last few decades “whereas wildfires have been increasing” amid drier conditions, Yazdi added.

In her research, Yazdi studies the specific particulate matter and gaseous pollutants that constitute air pollution, looking at the rates of cardiovascular and respiratory disease in response to these pollutants.

Mental health effects

Local health care providers recognized that a sudden and lasting orange glow, which blocked the sun and brought an acrid and unpleasant smell of fire, can lead to anxiety, which patients likely dealt with in interactions with therapists.

As for activity in the hospital, Dr. Poonam Gill, director of the Comprehensive Psychiatric Emergency Program at Stony Brook Hospital, said smoke from the wildfires did not cause any change or increase in the inpatient psychiatric patient population.

In addition to the eerie scene, which some suggested appeared apocalyptic, people contended with canceled outdoor events and, for some, the return of masks they thought they had jettisoned at the end of the pandemic.

“We had masks leftover” from the pandemic, and “we made the decision” to use them for an event for his son, said Schwaner.

When Schwaner contracted the delta variant of COVID-19, he was coughing for three to four months, which encouraged him to err on the side of caution with potential exposure to smoke and the suspended particulates that could irritate his lungs.

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Speakers at the “Africa: The Human Cradle" International Conference paying Tribute to Richard E. Leakey” on June 5. Photo by John Griffin/Stony Brook University

By Daniel Dunaief

Combative, loyal, determined, consequential, energetic and courageous. These are just a few of the many traits paleoanthropologists and others shared to describe the late Richard Leakey at the “Africa: The Human Cradle” memorial conference at Stony Brook University this week.

The founder of the Turkana Basin Institute in Kenya, Leakey, who partnered with SBU and received 34 grants from National Geographic over the course of his decades in science, was a part of nearly every presentation and discussion on the first day of the week-long event which closes tomorrow, June 9.

From left, Stony Brook University President Maurie McInnis with Louise Leakey on June 5. Photo by John Griffin/Stony Brook University

Held at the Charles B. Wang Center on the main campus, the conference brought together luminaries in the field who interlaced stories about their science in Africa with anecdotes — many of them humorous — about Leakey. Marilyn and Jim Simons, whose Simons Foundation announced last week that it was donating $500 million to the university, attended the entire slate of speakers on the first day.

Leakey was “one of the most important paleoanthropologists of our time,” Maurie McInnis, President of Stony Brook, said in opening remarks. His impact “can be felt across our campus and across the world.”

In an interview, former Stony Brook President Shirley Kenney, who helped bring Leakey to the university, suggested that he “put us into the elite of that whole research field.”

Leakey stubbornly entered his parents Mary and Louis’s chosen fields when he dropped out of high school, eager to make discoveries on his own and to contribute to his native Kenya.

In 1968, during a meeting at the National Geographic headquarters, Leakey “lobbied the committee to divert funding from his father’s money” to his own research, Jill Tiefenthaler, National Geographic CEO, said during her presentation.

‘Sitting on a knife edge’

Like Leakey, however, these scientists looked deep into the past to understand the lives of early humans, our distant ancestors and other organisms while looking for lessons that might help with the present and the future.

Dino Martins, Chief Executive Officer of the Turkana Basin Institute and Lecturer in the Department of Ecology & Evolutionary Biology, suggested that Leakey was driven by a sense of “childlike wonder” and a need to know “where we are, where we’re coming from and where we’re going.”

Leakey suggested that the extremely hot climate in Kenya was a potential model to understand how ancestral humans survived in hotter conditions, which are becoming increasingly prevalent amid global warming.

“There are many parallels in the past” in terms of extreme environments, Louise Leakey, director of public education and outreach for the Turkana Basin Institute and Richard and Meave Leakey’s daughter, said in an interview. “We’re sitting on this knife edge of really dramatic change now.” 

In addition to encouraging science in Africa, Leakey also believed in engaging with students and researchers from a range of backgrounds and experiences. He wanted to ensure that people from every continent had an opportunity to join the ranks of scientists.

When presenting his research on Homo naledi, an extinct human with a brain a third the size of modern humans from South Africa who created burial sites and left behind etchings on a cave wall, Lee Berger, National Geographic Explorer in Residence, explained that he wished Leakey “had seen this and I think he would have been really angry with me.”

Words from a devoted daughter

In the final presentation of the first day, Louise Leakey shared memories of her upbringing and her father.

Among many pictures of her father and his discoveries over the years, Louise shared one in which she highlighted a pipe in the corner of the photo.  She believed her father “rarely smoked it” but liked to pose with it in photos.

Louise Leakey speaks at the memorial conference for her father on June 5. Photo by John Griffin/Stony Brook University

Louise Leakey recalled how one of her father’s partners, Kamoya Kimeu, proved a valuable partner in the search for fossils. When Kimeu died soon after Richard Leakey, Kimeu’s daughter Jennifer reached out to Louise to raise money for his funeral.

Louise Leakey has since learned that Jennifer never saw her father searching for fossils in the field. Rather, she learned all about his exploits when her mother read his letters each night to her before she went to bed.

A second generation of the two families is working together, as Jennifer has joined Louise in some of her fossil hunting work. The two daughters are also creating a comic strip, in many languages, that depicts the two of them hunting for fossils.

Leakey believes Jennifer Kimeu will serve as an inspiration to other Kenyans.

On the east side of Lake Turkana, Leakey and her team recently discovered the new head of a fossil. Before his death, her father said it was “time you found new skull.” Richard Leakey was right.

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Turkana Basin Institute: Richard Leakey All photos downloaded with permission from: www.flickr.com Username: turkanabasin Password: knmwt15000

By Daniel Dunaief

Daniel Dunaief

What’s possible?

We can spend time criticizing each other, becoming nattering nabobs of negativity, as British Prime Minister Winston Churchill once said. We can also rue our lot in life or feel an overwhelming sense of dread about problems we can’t solve or conflicts we haven’t resolved.

Or …

Or we can get out and create a remarkable life.

That’s what happened with famed paleoanthropologist Richard Leakey.

Okay, so maybe he had a few advantages, like the fact that his parents Mary and Louis Leakey were already successful in the field and, unlike those of us who grew up on Mud Road near Gelinas Junior High School, he spent his formative years near and around fossils.

I recall digging in the back corner of my yard when I was young, convinced that I would pull up a dinosaur bone or reveal some incredible secret someone had hidden among the prickers and weeds. Yeah, no such luck.

And yet, the life of the late Richard Leakey offers exciting hope and opportunities for inspiration.

He didn’t graduate from high school, but he was successful and world-renowned.

Leakey’s life is “awe-inspiring,” demonstrating the “ability of one person to literally transform the world and leave it a better place,” Lee Berger, National Geographic Explorer in Residence, said in an interview.

National Geographic Society CEO Jill Tiefenthaler described the impact Leakey had on his home country of Kenya as “amazing” and the impact on the field as “remarkable,” particularly because he did it in a non-traditional way.

In an interview, Tiefenthaler credited the “army” of people who supported him with helping him achieve his goals.

“How do you move and get people to move with you?” Tiefenthaler said. “He was this person who saw talent. It wasn’t just about him. He would see [someone] and say ‘you’re going to do this’ and they did.”

Next generation

As for how to get the next generation to believe in themselves and to participate in the scientific process, National Geographic’s Berger and Tiefenthaler shared their vision.

Ensuring transparency in the process helps people trust the science.

“People are with us when we find those fossils, they watch us, we make sure there’s open access when they come out,” said Berger, who considered Leakey a friend and mentor. “Your child can print these things out and they can check.”

For National Geographic, which funded Leakey for decades, the goal is to “try to give people information and let them draw their own conclusions,” Tiefenthaler added.

The next generation of scientists has access to a large educational program through National Geographic, she added.

“I spent my career in higher education,” said Tiefenthaler, who was the president of Colorado College for nine years before becoming the first woman to lead National Geographic in its 135-year history. “We have got to meet them where they are: they are probably not reading the paper magazine with small, dense print.”

National Geographic is on social media and TikTok.

“We are focusing on issues they care about,” Tiefenthaler said. “We know this generation is very concerned about climate change and biodiversity loss.”

Tiefenthaler “loves how much they care about the work we do at National Geographic [Society]. They’re a little mad at [this generation] because of the predicament that we’ve left the world in for them. We made the mess and there are fewer resources to fix things.”

Still, she believes there are leaders and actors among the younger generation who will follow in Leakey’s footsteps and have an important and positive impact on the world.

“We have a generation that’s going to make major progress on this planet,” she said.

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National Geographic Explorer-in-Residence Lee Berger and leader of the excavation expedition, inside the Rising Star cave in South Africa where fossil elements belonging to H. naledi, a new species of human relative, were discovered. The find was announced by the University of the Witwatersrand, the National Geographic Society and the South African National Research Foundation and published in the journal eLife. Photo by Robert Clark/National Geographic
Where: Rising Star, formed within Dolomitic Limestone Lee Berger, the leader of the excavation expedition, inside the Rising Star cave, watches a monitor in the command center. Photo by Robert Clark/National Geographic
Discovered on July 28th, 2022. This picture shows an image of Panel B in the Hill Antechamber exhibiting numerous engravings and etchings on the ancient dolomitic wall. The panel shows repeated etchings likely done over a considerable period. The etchings include geometric figures such as squares, ladders, triangles, crosses, and X’s. Image from Berger et al. (2023b).
Discovered on July 28th, 2022. This picture shows an image of Panel B in the Hill Antechamber exhibiting numerous engravings and etchings on the ancient dolomitic wall. The panel shows repeated etchings likely done over a considerable period. The etchings include geometric figures such as squares, ladders, triangles, crosses, and X’s. Image from Berger et al. (2023b).
A closeup of the non-geometric image from the Hill Antechamber burial chamber that is found at the top of Panel B as described in Berger et al (2023b). Note the upside-down cross shaped etching to the left of the carving as well as other etchings to the right and below. The material discoloring the surface has not as yet been analyzed but appears to be secondarily applied to the surface in order to highlight the image in low light. Image from Berger et al., 2023.
An image of the Panel A crosshatch engraving in the passage between the Hill Antechamber burial chamber and the Dinaledi Burial Chamber from Berger et al (2023a). The image is taken using a polarizing filter to highlight the various non-natural etchings on the surface. The roughly horizontal wavy lines at the bottom of the image which are crossed by the engravings is a fossil algal stromatolite found in the native dolomitic rock. Earlier etchings can be seen behind the crosshatch, possibly having been obscured by covering the surface with cave dirt as described in the scientific papers. Image from Berger et al., 2023.
A close up of the base of the Panel A crosshatch engraving in the passage between the Hill Antechamber burial chamber and the Dinaledi Burial Chamber described in Berger et al (2023a). The roughly horizontal wavy lines at the bottom of the image which are crossed by the engravings is a fossil algal stromatolite found in the native dolomitic rock and clearly illustrate the non-natural origin of the more prominent etchings as they cross the fossil. Image from Berger et al., 2023.
Breaking news from the Richard Leakey Memorial Conference

By Daniel Dunaief

A species of archaic humans is defying conventional wisdom about what it means to be human.

Lee Berger, National Geographic Explorer in Residence and paleoanthropologist.

Homo naledi, which were discovered in a cave about 25 miles away from Johannesburg, South Africa, had brains that were about a third the size of ours. That, previous research suggested, likely limited their ability to engage in a range of activities, like burying their dead or creating symbols.

Wrong and wrong.

In an expedition through narrow caves that required him to lose 55 pounds just to get to the site, Lee Berger, National Geographic Explorer in Residence and Lead of the Rising Star program, along with a team of other scientists, studied the remains of these humans that lived over 236,000 years ago. The bones they studied and, in some cases excavated, were buried deep in the Rising Star Cave.

Along the wall of a cave, the researchers also found symbols, including crossed lines and swirls.

“Big brains don’t explain what we thought they explain,” Agustín Fuentes, Professor of Anthropology at Princeton University and National Geographic Explorer and On-Site Biocultural Specialist, said during a press briefing announcing the discoveries. This research “takes humans off the pedestal.”

The research, which was shared at the Richard Leakey Memorial Conference at Stony Brook University on June 5, is published in the journal eLife.

Berger wanted to share his latest findings with the conference, particularly given the important role Leakey played in his career.

Berger had known Leakey for 34 years. When they met, Leakey, who was his “idol,” directed Berger to follow his dream of searching for fossils in South Africa. Leakey and Berger remained close throughout the decades.

“I owe him my entry into this field,” said Berger.

Indeed, Berger feels that Leakey was, “in some ways, responsible for the discovery” about the burials and cave drawings of Homo naledi. “I’m very personally indebted” to Leakey.

Extraordinary effort

While scientists don’t know what the lines in the dolomitic limestone walls signified, they believe Homo naledi, whose name in Sotho language means “star,” made those marks. 

Natural processes over the course of over 200,000 years wouldn’t have left such a distinctive pattern. In addition, the depth of the markings, which would have taken considerable effort and a tool to create, indicate a concerted and sustained physical effort.

The dolomite is about half as hard as a diamond, which would have taken an “extreme amount” of work, Berger said. Several of the lines suggest multiple efforts to make carvings. “These are engravings that are not done in one sitting,” he said.

During the press briefing, Berger indicated that other species of early humans didn’t leave any evidence of entering the same cave. “There’s no evidence of humans” other than the scientists who published the paper “that entered the cave,” he said.

At this point, researchers, who are trying to minimize any disturbance in the cave, haven’t pinpointed an exact date for the symbols.

“In time, we’ll likely be able to date” the symbols, said Berger. The researchers arrived at the approximate date and linked the symbols to Homo naledi through association and context, he explained.

Homo naledi are the only humans who left any evidence of their presence in the cave.

Moments after discovery, Lee Berger holds a photographic scale next to a hashtag, or crosshatched engraving in the passage between the Hill Antechamber burial chamber and the Dinaledi Burial Chamber known as Panel A. Photo by Mathabela Tsikoane, Courtesy Lee Berger and the National Geographic Society.

Researchers described the arduous process of descending through narrow passageways to arrive at the burial site, which Berger discovered in 2013.

The site is extraordinarily difficult for modern humans to navigate. In addition to losing weight to get through small openings, Berger tore his rotator cuff climbing out of the site last July. He is still recovering, but said losing weight and even sustaining an injury was worth the effort.

While modern scientists use headlamps and battery-powered lights to record their discoveries, earlier humans would have had to carry some form of portable fire with them to bring their dead to their burial sites and to make carvings in the walls.

“How they’re making that fire and the exact mechanism of transport, I think, will be established over the next several years as we study all the occurrences of it,” Berger said.

“For us to say something clearly, definitely, strongly, again as [Berger] has said, we need to go back and excavate some more and check out more areas that we might have missed because clearly we walked straight past this,” said Keneiloe Molopyane, National Geographic Explorer and Lead Excavator of Dragon’s Back Expedition.

New perspectives

As far as a DNA analysis, the team hasn’t yet found anything they can test in the fossils. They are planning to test the sediment.

The researchers have left large amounts of evidence in place, which includes multiple other burials that haven’t been excavated. Berger suggested that the images and information from this site “provide as robust evidence for burial and graves as for practically any grave ever published for humans or otherwise.” Researchers examining this information will realize that “more works needs to be done.” As for what that entails, one of the plans is to bring additional technology and specialists into the area.

Homo naledi “intensely altered this space across kilometers of underground cave systems, and I think that deserves not just the involvement of our team, but the involvement of every scientist around the world who can participate, and perhaps technologists and other people who have ideas about how/ what we do,” Berger added.

As for the implications of this research, the scientists suggested that the discovery and the analysis will continue to alter the perspectives of researchers and students of human history.

“All of us who write textbooks or major articles about this probably have to go back and shift what we said about big brains, meaning, complex meaning-making behavior, or the kind of complex experiences of grief, social community, that’s associated with mortuary and funerary practices,” Fuentes said. “It makes us think about human evolution really in a new way, and puts us back closer to a starting point, and showing again that we know a lot less than we thought we did.”

 

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