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Cervo Design owner Andrea Cervo cuts the red ribbon at the April 19 grand opening ceremony. Photo by Rita J. Egan
Local legislators and residents join Amanda Haggquist, owner of Village Florist and Events, during the store's ribbon cutting April 19. Photo by Rita J. Egan
Brookhaven Town Supervisor Ed Romaine congratulates Sweet Mama's Family Restaurant owner Marios Patatinis on the grand opening of the restaurant. Photo by Rita J. Egan
Karen McAvoy, owner of Madison's Niche, celebrates the grand opening of her home and clothing store with local legislators and residents. Photo by Rita J. Egan
Jeff Norwood, owner of Camera Concepts & Telescope Solutions, cuts the red ribbon during the grand opening of his business. Photo by Rita J. Egan

By Rita J. Egan

On April 19, residents joined Stony Brook Village Center President Gloria Rocchio, Chairman Dr. Richard Rugen, Brookhaven Town Supervisor Ed Romaine (R), Councilwoman Valerie Cartright (D-Port Jefferson Station) and Three Village Chamber of Commerce President Andrew Polan in welcoming five new businesses to the center.

The grand opening and ribbon cutting stroll included gift and clothing store Madison’s Niche, Camera Concepts & Telescope Solutions, interior design business Cervo Design, Village Florist and Events and Sweet Mama’s Family Restaurant. Before and after the ribbon cuttings, attendees had the opportunity to stroll through each establishment, and enjoyed refreshments at Cervo Design and Sweet Mama’s.

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Poquott's Village Hall. File photo

By Rita J. Egan

As the Village of Poquott board of trustees budgets for the upcoming fiscal year, the cost of a proposed dock is still at the forefront of a few residents’ minds.

At an April 12 village public hearing, board members approved the 2018-19 preliminary budget. The village plans to spend $533,839 in the upcoming fiscal year, about a $34,000 increase over the last period. The preliminary budget stays under the tax levy increase cap, with an anticipated tax rate of $15.41 per $100 of assessed property value.

Treasurer Ron Pulito said it is estimated about $34,000 of the budget will be to pay the first installment of a five-year note for the village’s proposed dock. This amount would be taken from the village’s fund balance. The dock was originally estimated at $150,000 but the board opened bids at the beginning of the April meeting and the proposals were higher than anticipated.

“We have a good budget next year with question marks next to what happens with the dock, and we’re staying under the cap.”

— Ron Pulito

Pulito said there will be an estimated $47,000 deficit the current fiscal year, which would leave approximately $55,000 in the village fund balance. He said he does not expect much change in costs like snow plowing and garbage collection, and he said not much would be needed from the fund balance in the future for those items. He said while the budget includes funding for the dock it didn’t include any work on village hall.

“We have a good budget next year with question marks next to what happens with the dock, and we’re staying under the cap,” Pulito said.

Resident Felicia Chillak said she was concerned that the fund balance isn’t as high as past years and asked what would happen if there was a microburst storm like the one that hit the village a few years ago. She said the first day of cleanup after the storm cost the village $30,000.

“I personally feel [it’s better] to leave the fund balance and raise the taxes a little bit, if that’s going to keep us on the safer side,” Chillak said.

If the board decides not to go ahead with building the dock, the treasurer said the budget would break even. Pulito said if the board does go forward with the construction and more funds are needed, the village may be able to apply for a loan with a longer payment period.

“If you can’t afford it, you can’t afford it,” resident Cindy Davis said. “You don’t go ahead. You don’t bust your budget for something like this.”

A decision on dock bids was tabled until May. The board will vote on the final 2018-19 budget in an upcoming meeting.

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The Bates House in Setauket will host Camp Kesem at Stony Brook University's fundraising event. File photo

Camp Kesem at Stony Brook University is planning its annual fundraising gala, Make the Magic. The event will be held at The Bates House in Setauket April 21 starting at 5 p.m.

The gala will include a cocktail hour, dinner, silent auction, paddle raise, prizes and more. Tickets are $65 per person or $500 for a table of eight.

Vacation prizes include a Zulu reserve trip to Africa for two, Royal Caribbean International cruise for two, a Florida trip to the Hilton Cocoa Beach Oceanfront for four and a Martha Clara Vineyards wine trip for six.

Camp Kesem is a nonprofit organization run by college students who are committed to providing programs and free summer camp to support children in the Long Island community who are impacted by a parent’s cancer.

For more information, contact Camp Kesem members at 631-716-5173 or email [email protected]. To learn more about Camp Kesem, visit www.campkesem.org/stonybrook. 99The Bates House is located at 1 Bates Road in Setauket.

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Zeldin celebrates his 2016 election night victory in Patchogue. File photo by Alex Petroski

The race for the right to challenge New York’s 1st Congressional District U.S. Rep. Lee Zeldin (R-Shirley) in November will be a five-way battle.

The candidates got enough signatures from voters to qualify to be placed on the ballot for the June 26 Democratic primary ahead of the April 12 deadline. June’s winner will face the two-time incumbent congressman and fervent supporter of President Donald Trump (R) in the general election Nov. 6. New York’s primaries are only open to registered members of the applicable political party.

Kate Browning

Kate Browning. Photo from SCDC

Browning is the former 3rd District Suffolk County legislator, a position she held beginning in 2005 before
being term limited out of office. She was born and raised in Belfast, Northern Ireland, before moving to Germany at 19 years old and eventually landing in Shirley with her husband Steve in 1989. The mother of three was a bus driver in the William Floyd School District prior to taking office.

“Our district deserves a representative that is going to fight for working families in Suffolk County,” Browning says in a section of her website entitled “Why I’m running,” while also touting her ability to work across the
political aisle. “I’ve focused on quality of life issues, rehabilitating foreclosed zombie homes and selling them to first-time home buyers, keeping them away from speculators and absentee landlords. And I’ve secured funding for clean water infrastructure to protect our drinking water and our shorelines.”

Elaine DiMasi

Elaine DiMasi. Photo from SCDC

DiMasi, a political newcomer, was a federal contractor for more than 20 years in addition to more than two decades of experience as a project manager and physicist at Brookhaven National Lab. She describes herself as a lifelong environmentalist with firsthand knowledge about the potential to jump-start the local economy while safeguarding the environment through the establishment of clean energy jobs.

“I dare to believe in a government that cares for all its people equally, is responsive to them and their concerns,” she says on her campaign website. “An American future that values equality for its people that opens doors of opportunity for all. An America that leads by example through its laws and practices to ensure the dignity, well-being, and freedom of all people.”

Perry Gershon

Perry Gershon. Photo from SCDC

Gershon wastes no time in his personal bio on his campaign website declaring he is a businessman, and not a career politician, having spent more than 25 years in commercial real estate finance. The first-time runner for office says his decision to leave the private sector and seek political office is a byproduct of outrage at the state of politics in Washington, D.C. He points to his entrepreneurial spirit and ability to build consensus among diverse parties as evidence of his qualifications to represent NY1.

“I’m fed up,” he says on his campaign website as to why he’s running. “It’s time Long Island had a strong voice to fight for high-paying jobs, affordable health care, high-quality education and clean air and water. Rather than stand by as Donald Trump and Washington politicians try to divide us, we can rebuild the middle class.”

Gershon and his wife Lisa have two sons and live on the South Fork.

David Pechefsky

David Pechefsky. Photo from SCDC

Pechefsky has extensive experience in government despite never holding elected office. The 1986 valedictorian at Patchogue-Medford High School has held various positions in government and politics during the last 20 years, including as a longtime staffer for the New York City Council, as well as a consultant for the National Democratic Institute from 2010-13. There, he worked to establish a legislative budget office to serve the Congress of Liberia. He also managed a U.S. government-funded program to strengthen the parliament of Somalia. He’s on leave from his current job as a senior adviser with Generation Citizen, a national nonprofit with the goal of fostering civic engagement.

“I am running for Congress because we need to put in place policies that make our economy work for everyone, not just the wealthy,” he says on his website. “I’ve spent my career working in government here in America and as an adviser to governments around the world and know how government can and should work to make things better for all us.”

Vivian Viloria-Fisher

Vivian Viloria Fisher. Photo from SCDC

Viloria-Fisher was also a Suffolk County legislator, serving the 5th District 13 years beginning in 1999. She was born in the Dominican Republic before moving to New York with her family as a child. She also worked as a Spanish teacher in Three Village school district for 12 years.

“As your representative, I will: fight for a national living wage; support job growth in sustainable energy and medical research industries; reinstate tax deductions for workers and students,” she says on her website, among other legislative priorities.

She touts her work on expanding public transportation services, creating a Welfare-to-Work commission in the county and her support for marriage equality prior to its legalization in New York among her proudest accomplishments.

Check TBR News Media in print and online for coverage of both the primary and general election in the coming weeks and months. All information about the candidates is from the Suffolk County Democratic Committee website or the candidates’ campaign sites.

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Starting pitcher slams a double, scores game-winning run to go with 11 Ks during his complete game

Starting southpaw Max Nielsen hurls a pitch. Photo by Desirée Keegan

Nothing is stopping Ward Melville’s starting pitcher Max Nielsen from winning a game.

Trading a ball for a bat, the lefty led off the bottom of the fourth with a double, knocking the ball into the outfield on a bad bounce, and two more hits eventually scored what would be the game-winning run in a 2-1 Patriots victory over Patchogue-Medford April 17.

Brady Doran gets under an infield popup. Photo by Desirée Keegan

Nielsen, who added 11 strikeouts from the mound during a complete game while allowing just three hits and one walk, said he knew he’d won the game once he crossed home plate.

“I knew that was going to be the run that’d win it for us,” the southpaw said. “Because I knew I wasn’t going to give up another run.”

The junior allowed hits in the first and second and hit a batter in the second before a Patchogue-Medford bunt loaded the bases. He struck out the following hitter but allowed the only run later in the same inning. He surrendered his only walk in the top of the fourth, but also struck out two to get back on track.

“I always try to give my team the best opportunity to win,” Nielsen said. “I wanted to get ahead with the fastball, because once I get ahead I can start going through my other pitches and making it harder on the hitters. I had a rough second inning, but my defense got me out of it.”

Logan Doran and Kyle Rafferty each went 2-for-3 with a stolen base. Doran scored the Patriots’ only other run, and his brother Brady Doran also went 2-for-3. While the brothers said Ward Melville was slow to start, the Patriots are now firing on all cylinders, feeling in their element.

Brady Doran, Kyle Rafferty and Alex Russo leap up in celebration after the win. Photo by Desirée Keegan

“I wanted to attack the fastball, and he had a pretty good curveball,” junior second baseman Brady Doran said of Patchogue-Medford’s pitcher. “I’m comfortable, stay confident and try to attack the fastball and hit it hard. We gel; we’re a close team that really plays well together.”

Nielsen shared a similar sentiment, but said the funny feelings from the team’s uneven start are gone now.

“I can’t think of a weakness,” he said. “Our defense is great, I know all of the pitchers on staff are going to give us a great game and we hit.”

Head coach Lou Petrucci said he thought his southpaw controlled the game, and said he liked that he stayed under 100 pitches. Petrucci said the Raiders’ record didn’t fool him (2-7), because he knew he’d be facing a challenging opponent.

“Randall [Alejo] pitched a great game and we got away with a win today,” he said. “It’s a big rivalry game. We tried to have good at -bats, put good swings on the ball, we didn’t strike out much and the kids are showing great improvement. Our pitching staff is keeping the scores down, and now we’re working on getting the clutch hits, but we’re playing hard.”

The Patriots have now won five straight and are tied with Sachem East (7-2) at the No. 2 spot in League I behind Longwood (8-1). Ward Melville travels to Patchogue-Medford for Game 2 of the series. The first pitch is scheduled for 4:15 p.m.

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Sheryl Cohn stands in her home’s guest bedroom where the ceiling crashed and fell onto the bed during Hurricane Sandy. Photo by Kyle Barr

Though it’s been more than five years since Hurricane Sandy ravaged Long Island, many people, including Huntington Station resident Sheryl Cohn, are still feeling its effects like the storm only happened yesterday.

Black mold in the basement of Cohn’s home is an aftereffect of Hurricane Sandy. Photo by Kyle Barr

In an interview after the April 11 public hearing at Stony Brook University conducted by the Suffolk County Legislature’s Superstorm Sandy Review Task Force, Cohn said her roof was ruined in the wake of the storm, and her house is falling apart around her. The ceiling in her guest bedroom fell and crashed onto the bed, and black mold has sprouted in many rooms around her house. The masonry on the outside of her home — finished only a few months before Sandy hit — fell to pieces on her driveway. She lives in fear that a piece of ceiling will fall on her head while she sits or sleeps.

“My grandson, he turned five in March, he has never been here,” Cohn said. “I would never be able to forgive myself if, God forbid, he contracted something or a piece of sheetrock fell on his head. It makes me feel horrible. He lives a half an hour away, and he’s never been to Nana’s house.”

She first looked into a contractor to fix her roof, but the firm she hired disappeared with all of the money she had already given them. She said the NY Rising Community Reconstruction Program, the state program that was created to provide aid to people whose homes were damaged during the storm, has constantly told her wrong information and switched caseworkers with her multiple times. Now she says they have stopped returning her calls and emails. Five and a half years later she still has no progress on acquiring any financial aid.

As some of the effects of Sandy linger on, Legislator DuWayne Gregory (D-Amityville), the Legislature’s presiding officer, helped to create the Superstorm Sandy Review Task Force, a 27-member committee of government representatives, scientists, engineers and other experts to make recommendations on how to deal with the lasting effects of Sandy as well as prepare Suffolk County for the next big storm.

“My grandson, he turned five in March, he has never been here. I would never be able to forgive myself if, God forbid, he contracted something or a piece of sheetrock fell on his head.”

— Sheryl Cohn

The task force is divided into four working groups including emergency response, resiliency, recovery and infrastructure.

“As we go and narrow down the issues they want to focus on, we want to look at what went wrong, what are the recommendations, what are the solutions,” said Joshua Slaughter, Gregory’s aide. “We don’t want to reinvent the wheel, but we want to come out with things to make it better.”

The task force plans to have more meetings and come up with a document by December that will provide recommendations for the county.

While much of the focus of the task force is focused on the South Shore, where the damage was much more severe, problems from the North Shore not only deal with damaged property but the severe risk of beach erosion and property loss for people living close to the shore.

Professor of oceanography at Stony Brook University and task force member Malcolm Bowman said there is not enough solid data to say that “storm of the century” Sandy won’t be repeated in the near future and that rising sea levels will make each new storm do more damage.

“Five, 10, 25 years from now it will take less of a storm to do the same amount of damage,” Bowman said. “That is the challenge that we have to think about and be prepared for.”

Malcolm Bowman discusses ways to fix Long Island’s receding beachline at a Superstorm Sandy Review Task Force public hearing held April 11 at Stony Brook University. Photo by Kyle Barr

There are both natural solutions and engineered solutions up in the air for trying to fix Long Island’s receding beachline, according to Bowman. Natural solutions include planting seagrass and reestablishing oyster beds to hold the land in place, while engineering solutions include barriers and other human-made structures. Bowman said that both will come into play when preparing for upcoming storms.

Regarding aiding those who are still affected by Sandy navigate their recovery, Slaughter said the task force was thinking about recovery advocates, somebody who can be hired by the state to work with people on a consistent basis.

“I know it will be difficult, there are a lot of cases, but if you leave it to that one on one, people will be running forever, and not every consumer can get out as well as others,” Slaughter said.

“The vast, vast majority of our contractors did the best to their ability, but of course the ones we hear about are those who put people in a bad position or were unscrupulous,” chair of the task force Dave Calone said. “Our job as a governmental entity is to make recommendations to limit that as much as possible.”

Another task force meeting took place April 18 at the Southampton Town Hall. Two more meetings are scheduled for April 26 at Patchogue-Medford High School and May 2 at Babylon Town Hall.

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Budget stays within 1.97 percent cap

On Feb. 13, parents of Setauket Elementary School students spoke to the board of education about establishing a districtwide sustainability and wellness task force. File photo

The Three Village Central School District Board of Education has adopted a $209.8 million budget for the 2018-19 school year.

Among its proposals are additional resources for student mental health and counseling services, athletic training and elementary science.

Jeff Carlson, assistant superintendent for business services, who outlined the budget at the April 12 meeting, said it will stay within the 1.97 percent cap on the tax levy increase. There will also be no cuts for budgetary reasons, he said.

Jeff Carlson laid out the 2018-2019 school budget at the April 12 board of education meeting. File photo

As far as revenue, New York State will give the district an additional $833,579 in state aid, for a total of $34.4 million, Carlson said. The amount does not include building aid, which is tied to specific capital improvements and varies from year to year, he said.

The assistant superintendent said the budget is based on a combination of declining enrollment, staffing changes, student interest in courses across the secondary level and administrative restructuring. The result is easing the way for the proposed enhancements, he said.

Big changes will happen at the secondary schools, where enrollment in some courses will result in a reduction of two to three full-time equivalent positions, Carlson said. The district will therefore be able to add one FTE for another guidance counselor at Ward Melville High School and a .5 FTE for a psychometrician — a psychologist to conduct testing throughout the district. District Superintendent Cheryl Pedisich said the addition will give school psychologists more availability to counsel students, a decision motivated, in part, by the tragic events in Parkland, Florida.

“We believe that as part of our safety and security procedures and protocol, the need for clinical staff — and a robust staff — is critical to our efforts,” Pedisich said at the March 28 board meeting.

Also, with an eye toward student safety, the administration plans to add an assistant athletic trainer to increase coverage at the district’s athletic events, she said. For greater accountability, the budget includes a transition coordinator to help special needs students transition to the workforce or to the next stage after high school, Pedisich said. This addition will come at a nominal cost, since the district had previously contracted out the position, she said.

The retirement of two administrators — the high school chair of foreign languages and the assistant director of health and physical education— will result in the reduction of two to three FTEs, allowing the district to combine certain positions to be more “effective in terms of the delivery of curriculum,” the superintendent said. One new position will be a district-wide director of foreign language and English as a New Language for kindergarten through 12. Rather than having separate administrators for health and physical education for grades seven through nine and then for 10 through 12, there will be one coordinating chair of physical education and health for all secondary grades and another for kindergarten through sixth grade, she said.

“We believe that as part of our safety and security procedures and protocol, the need for clinical staff — and a robust staff — is critical to our efforts.”

— Cheryl Pedisich

The district will also restore one FTE of clerical help for junior high media specialists and one FTE for a maintenance specialist to increase cost efficiency, Pedisich said.

Similarly, declining enrollment at the elementary level will help the district to maintain a low student-teacher ratio, while also introducing third-grade orchestra at no additional cost to the district.

With the continued decline in elementary school enrollment — between 120 and 130 students next year — there will be two to three fewer sections to staff and a possible decrease of two FTEs, Pedisich said. That will allow the district to add three teaching assistants plus an additional .5 FTE from junior high science staffing — again, due to lower enrollment — to help prepare for the 2020 implementation of the Next Generation Science Standards, Pedisich said. Two more teaching assistants will come from existing staffing.

The Three Village free preschool program at Nassakeag Elementary School will continue into its second year. By the end of March, there were already 128 children enrolled, up from 109 this school year. The district can accommodate up to 200 students and has budgeted up to five FTEs for teachers should the program reach capacity.

Carlson said there will be an increase in the district’s contributions to the employee and teacher retirement systems. To cover the $1.5 million increase, the district will use funds from its reserves, which, he said, are set aside to cover employee retirement costs.

The vote to approve the budget will be held May 15, from 6 a.m. to 9 p.m. Like last year, for security reasons, the vote will take place at the secondary schools. Those zoned for Arrowhead, Minnesauke and Nassakeag elementary schools will vote at Ward Melville High School, while residents zoned for Mount Elementary School will vote at Murphy Junior High. Families zoned for Setauket Elementary will vote at Gelinas Junior High.

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Cedar Beach waters in Mount Sinai run into the Long Island Sound. File photo by Elana Glowatz

Suffolk County has signed off on joining New York State in suing the Environmental Protection Agency for dumping dredged materials in Long Island Sound.

Gov. Andrew Cuomo (D) and New York Attorney General Eric Schneiderman (D) announced last summer the state would be taking legal action against the EPA after in 2016 the agency moved to increase the number of open water dumping sites in the Sound from two to three, despite a call from state government leaders of both New York and Connecticut in 2005 to reduce and eventually eliminate the practice of dumping in the Sound.

The Eastern Long Island Sound Disposal Site, now a permanent open water site for the disposal of dredged materials, is midway between Connecticut and New York, and less than 1.5 nautical miles from Fishers Island, which is part of Southold Town and Suffolk County, despite technically being in Connecticut’s waters. The disposal site is in an area that had never before been used for open water disposal.

Legislator Al Krupski (D-Cutchogue), who represents Southold, Riverhead and communities in eastern Brookhaven, initiated the legislation directing Suffolk County to join the action against the EPA.

“This is another step in a decades-long fight to try and get the EPA to play by the rules,” Krupski said. “The Long Island Sound is threatened by pollution, warming waters and acidification, and the last thing that should be done is to dump potentially toxic substances into the estuary.”

Legislators Sarah Anker (D-Mount Sinai), Kara Hahn (D-Setauket), William “Doc” Spencer (D-Centerport) and Leslie Kennedy (R-Nesconset) joined Krupski in sponsoring the legislation authorizing the county to join the lawsuit.

“For more than the 30 years, leaders from both shores of the Long Island Sound have invested heavily on a cooperative effort to restore its life and majesty,” said Hahn, the chairwoman of the Legislature’s Environment, Planning & Agriculture Committee. “As such, the decision by our neighbor to the north to dump potentially toxic pesticides, heavy metals and industrial by-products into the Sound is nearly as dumbfounding as the Environmental Protection Agency’s willingness to allow it.”

Cuomo made the case against expanded dumping when the lawsuit was announced.

“We will continue to do everything in our power to protect New York’s environment, and with the EPA’s unfathomable and destructive decision to turn the eastern Long Island Sound into a dumping ground — now is the time for action,” Cuomo said in 2016. “We will establish that this designation not only poses a major threat to a significant commercial and recreational resource, but that it also undermines New York’s long-standing efforts to end dumping in our treasured waters.”

Last year, Brookhaven and Southold towns joined the lawsuit, which contends the EPA failed to adequately investigate alternatives to open water disposal and overestimated the need for the new site. It also alleges the Long Island Sound Dredged Material Management Plan, which was approved by the EPA, violates the Ocean Dumping Act and Coastal Zone Management Act, and cited a “failure to address environmental impacts on the Long Island Sound.” The body of water was designated an Estuary of National Significance by the EPA in 1988 and is recognized as an important economic engine for Suffolk County and all of Long Island, supporting both recreational and commercial businesses and contributing billions of dollars to the regional economy.

“We’re here to send a very strong message — that we are opposed to dumping in the Sound,” Romaine said during a press conference Aug. 28 at Cedar Beach in Mount Sinai. “The State of New York and this governor, Andrew Cuomo, has done a great service to this state and to the residents of Long Island by working to enjoin, in the court, the EPA from allowing continued dumping in the Sound.”

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Maurizio Del Poeta. File photo from SBU

By Daniel Dunaief

Sometimes, fixing one problem creates another.

People with multiple sclerosis have been taking a medication called fingolimod for a few years. The medicine calms immune systems that attack the myelin around nerve cells. Fingolimid decreases the lymphocyte number in the bloodstream by trapping them in the lymph nodes.

In a few cases, however, the drug can reduce the immune system enough that it allows opportunistic infections to develop. Cryptococcosis, which is a fungal infection often spread through the inhalation of bird droppings or from specific trees such as eucalyptus, is one of these infections, and it can be fatal if it’s not caught or treated properly, especially for people who have weakened immune systems.

Swiss pharmaceutical giant Novartis contacted Stony Brook University fungal expert Maurizio Del Poeta, a professor in the Department of Molecular Genetics & Microbiology, to understand how this drug opens the door to this opportunistic and problematic infection. He is also exploring other forms of this drug to determine if tweaking it can allow the benefits without opening the door to problematic infections.

Most of the human population has been exposed to this fungus. In a study in the Bronx, over 75 percent of children older than 2 years of age had developed an antibody against Cryptococcus neoformans, which means they have been exposed to it. It is unknown whether these people harbor the fungus or if they have just mounted an immune reaction. Exposure may be continuous, but infections may only occur if a person is immunocompromised.

Fingolimid “inhibits a type of immunity” that involves the movement of lymphocytes from organs into the bloodstream,” Del Poeta said. “Because of this, there are certain infections that can develop.”

Through a spokeswoman, Novartis explained that the company was “happy to have started a scientific collaboration” with Del Poeta to understand the role of a specific pathway in cryptococcus infections.

Cryptococcal meningitis is one of several infections that can develop. Others include herpes meningitis and disseminated varicella zoster. Before starting fingolimid, patients need to receive immunization for varicella zoster virus. At this point, doctors do not have a vaccine for cryptococcosis.

To study the way this drug and its derivatives work, Del Poeta recently received a $2.5 million grant over a five-year period from the National Institutes of Health.

Yusuf Hannun, the director of the Cancer Center at SBU, was confident Del Poeta would continue to be successful in his ongoing research.

Del Poeta “does very important and innovative work on fungal pathogenesis and he is a leader in the field,” Hannun wrote in an email. “His work will enhance our understanding of the molecular mechanisms.”

Fingolimid mimics a natural lipid. Years ago, Del Poeta showed that this sphingolipid, which is on the external surface of the membrane, is important to contain cryptococcosis in the lung. If its level decreases, the fungus can move from the lung to the brain.

While people with multiple sclerosis have developed signs of this infection, it is also prevalent in areas like sub-Saharan Africa, where people with AIDS battle cryptococcosis. About 40 percent of this HIV population develops this fungal infection, Del Poeta said. About 500,000 people die of cryptococcosis every year.

In certain areas of the United States, such as the Pacific Northwest, this fungus is also endemic. On Vancouver Island, about 19 people died from Cryptococcus gattii infections between 1999 and 2007. Most of those patients were immunocompromised.

When the fungus migrates from the lung to the brain, it is “very difficult, if not impossible in most cases, to eradicate,” Del Poeta explained in an email. If the diagnosis is made early enough before the infection spreads to the brain, the recovery rate is high, he suggested. In people whose immune systems are not compromised by drugs or disease, “death is rare.” 

Del Poeta plans to study the interaction between the drug and the fungal infection through a mouse model of the disease. The mouse model mimics the human disease and will provide insights on how to control the infection, particularly when the fungus reaches the brain.

Some of the derivatives Novartis has developed do not cause a fungal infection. Del Poeta is working with Novartis to study other forms of fingolimid that do not reactivate cryptococcosis. Del Poeta said Novartis is currently in Phase III clinical trials for another drug for multiple sclerosis. The new drug acts on a different receptor.

“We think the reason the fingolimid reactivates cryptococcosis is that it is blocking one receptor, which is important for the containment” of the fungus. The other drug doesn’t allow the disease-bearing agent to escape.

“This is a hypothesis,” Del Poeta said. He is waiting to corroborate the cell culture data in animal models.

Del Poeta has been working with Novartis for over three years. The Stony Brook scientist used some preliminary studies on the way fingolimid analogs behave as part of the research grant application to the NIH that led to the current grant.

Del Poeta said he is excited about the possibility of contributing to this area.

“Not only will this work contribute to the field of MS, but it will also have a contribution to the field of cryptococcosis,” he said. “This will have important implications for MS patients [and] for the entire HIV population.” He said he believes patients may have some other defect. If he is able to discover what that is, he may be able to protect them from a cryptococcosis infection.

Ultimately, Del Poeta hopes this work leads to a broader understanding of fungal infections that could apply to other pathogens as well.

“Mycobacterium tuberculosis causes a granuloma very similar to the one caused by the cryptococcosis and we could potentially study whether the same molecular mechanisms involved in the control of the infection in the lung are similar between the two infections,” he explained in an email.

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Lee Koppelman, right is presented with a replica of the sign that will mark a nature preserve dedicated in his honor, by Brookhaven Councilwoman Valerie Cartright, state Assemblyman Steve Englebright and Brookhaven Supervisor Ed Romaine. Photo by Alex Petroski

A public servant with more than four decades of planning experience now has a nature preserve with his name on it to honor his life’s work.

Brookhaven Town Supervisor Ed Romaine (R) and Councilwoman Valerie Cartright (D-Port Jefferson Station) hosted a ceremony at Jefferson’s Ferry Life Plan Community in South Setauket April 13 to dedicate a 46-acre parcel of woodlands in Stony Brook in honor of Lee Koppelman, who served as the first Suffolk County planner, a position he held for 28 years. He also served as regional planner for Suffolk and Nassau counties for 41 years.

“When you come to talk about preserving land; when you come to talk about planning communities; when you come to talk about vision; when you come to talk about master planners and you put that with Suffolk County, only one name comes up,” Romaine said of Koppelman. “When I look at the picture of the woods that will be named for Dr. Koppelman I can think of no better tribute to this man … Suffolk is in a large part what it is today because of this man’s vision, our master planner.”

Romaine lauded Koppelman for his dedication to preserving nature, including shoreline, wooded areas, wetlands and more. State Assemblyman Steve Englebright (D-Setauket), who served on the Suffolk County Legislature along with Romaine in the 1980s when Koppelman was also working for the county, repeatedly used the word “bold” in thanking Koppelman for his dedication.

“Suffolk is in a large part what it is today because of [Lee Koppelman’s] vision, our master planner.”

— Ed Romaine

“We had a master planner with a vision for this county that was daring and bold and unprecedented for any county in the United States,” Englebright said. “To set aside parkland — not like little pieces of confetti, but as whole sections of ecosystems and landscape segments — bold ideas. Not only was Dr. Koppleman the master planner, he was a master administrator. He hired extraordinary planners, talented people to serve with him.”

According to a press release from the town, Koppelman is regarded as the father of sustainability on Long Island, calling him the first of the “power players” to conceptualize the idea of preserving space in the interest of health and future generations. The Lee Koppelman Preserve is a heavily wooded parcel with a variety of deciduous tree and shrub species, or foliage that sheds its leaves annually. The town has owned the Stony Brook property just east of Nicolls Road and south of Stony Brook University, for about 45 years, using it as passive open space.

Cartright said she was honored to be a part of the dedication to such a prominent figure who had an impact on her district.

“Unfortunately, I didn’t have as much time to work with Dr. Koppleman as it relates to land use and planning, but it is clear to me he has left an indelible mark here within our community,” she said.

Koppelman joked that he wished the ceremony didn’t sound so much like a eulogy, though he said he was honored to be recognized by people he had considered friends for so long.

“Having that from them is a particular pleasure,” he said.

His wife Connie Koppelman was also in attendance and joked she had heard her husband honored so many times it was getting old, but called it very pleasing to hear once again how much his work was appreciated by those around him.

Koppelman currently heads the Center for Regional Policy Studies at Stony Brook University.

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