Stony Brook University

The temperatures at the poles are heating up more rapidly than those at the equator. Pixabay photo

By Daniel Dunaief

On any given day, heat waves can bring record-breaking temperatures, while winter storms can include below average cold temperatures or snow.

Edmund Chang. Photo from SBU

Weather and climate experts don’t generally make too much of a single day or even a few days amid an otherwise normal trend. But, then, enough of these exceptional days over the course of years can skew models of the climate, which refers to average temperature and atmospheric conditions for a region.

If the climate is steady, “we should see approximately the same number of hot and cold records being broken,” said Edmund Chang, Professor at the School of Marine and Atmospheric Sciences at Stony Brook University. “Over the past few decades, we have seen many more hot records being broken than cold records, indicating the climate is getting hotter.”

Recent heat

Indeed, just last week, before a heatwave hit the northeastern United States, the United Kingdom reported the hottest day on record, with the temperature at Heathrow Airport reaching above 104 degrees.

Erinna Bowman, who grew up in Stony Brook and has lived in London since 2009, said the temperature felt “like a desert,” with hot, dry heat radiating up in the urban setting. Most homes in London don’t have air conditioning, although public spaces like supermarkets and retail stores do.

“I’m accustomed to the summer getting quite hot, so I was able to cope,” said Bowman. Indeed, London is usually considerably cooler during the summer, with average temperatures around 73 degrees.

Michael Jensen. Photo from BNL

News coverage of the two extraordinarily hot days in London “was very much framed in the context of a changing climate,” Bowman said. The discussion of a hotter temperature doesn’t typically use the words “climate change,” but, instead, describes the phenomenon as “global heating.”

For climate researchers in the area, the weather this summer has also presented unusual challenges.

Brookhaven National Laboratory meteorologist Michael Jensen spent four years planning for an extensive study of convective clouds in Houston, in a study called Tracking Aerosol Convection Interactions, or Tracer.

“Our expectation is that we would be overwhelmed” with data from storms produced in the city, he said. “That’s not what we’re experiencing.”

The weather, which has been “extremely hot and extremely dry,” has been more typical of late August or early September. “This makes us wonder what August is going to look like,” he said.

Jensen, however, is optimistic that his extensive preparation and numerous pieces of equipment to gather meteorological data will enable him to collect considerable information.

Warming at the poles

Broadly speaking, heat waves have extended for longer periods of time in part because the temperatures at the poles are heating up more rapidly than those at the equator. The temperature difference between the tropics and the poles causes a background flow from west to east that pushes storms along, Chang explained.

The North Pole, however, has been warming faster than the tropics. A paper by his research group showed that the lower temperature gradient led to a weakening of the storm track.

When summer Atlantic storms pass by, they provide relief from the heat and can induce more clouds that can lead to cooler temperatures. Weakening these storms can lead to fewer clouds and less cooler air to relieve the heat, Chang added.

Rising sea levels

Malcolm Bowman. Photo from SBU

Malcolm Bowman, who is Erinna Bowman’s father and is Distinguished Service Professor at the School of Marine and Atmospheric Sciences at Stony Brook University, believes the recent ice melting in Greenland, which has been about 10 degrees above normal, could lead to a rise in sea levels of about one inch this summer. “It will slowly return to near normal as the fresh water melt spreads slowly over all the world’s oceans,” he added.

Bowman, who has studied sea level rises and is working on mitigation plans for the New York area in the event of a future major storm, is concerned about the rest of the hurricane season after the level of warming in the oceans this summer. 

“Those hurricanes which follow a path over the ocean, especially following the Gulf Stream, will remain strong and may gather additional strength from the heat of the underlying water,” he explained in an email.

Bowman is the principal investigator on a project titled “Long Island South Shore Sea Gates Study.”

He is studying the potential benefit of six possible sea gates that would be located across inlets along Nassau and Suffolk County. He also suggests that south shore sand dunes would need to be built up to a height of 14 feet above normal high tide.

Meanwhile, the Army Corps of Engineers has come up with a tentatively selected plan for New York Harbor that it will release some time in the fall. Bowman anticipates the study will be controversial as the struggle between green and grey infrastructure — using natural processes to manage the water as opposed to sending it somewhere else — heats up.

As for the current heat waves, Bowman believes they are a consistent and validating extension of climate change.

Model simulations

In his lab, Chang has been looking at model simulations and is trying to understand what physical processes are involved. He is comparing these simulations with observations to determine the effectiveness of these projections.

To be sure, one of the many challenges of understanding the weather and climate is that numerous factors can influence specific conditions.

“Chaos in the atmosphere could give rise to large variations in weather” and to occasional extremes, Chang said. 

Before coming to any conclusions about longer term patterns or changes in climate, Chang said he and other climate modelers examine collections of models of the atmosphere to assess how likely specific conditions may occur due to chaos even without climate change.

“We have to rule out” climate variability to understand and appreciate the mechanisms involved in any short term changes in the weather, he added.

Still, Chang said he and other researchers are certain that high levels of summer heat will be a part of future climate patterns. 

“We are confident that the increase in temperature will result in more episodes of heat waves,” he said.

Stony Brook Breast Cancer Screening mobile truck. (8/24/18)

By Daniel Dunaief

Some groups of people on Long Island have a much higher incidence of a particular type of cancer than others.

On an age adjusted rate, African American men, for example, were almost twice as likely to develop prostate cancer from 2014 to 2018 as Caucasians. Out of 100,000 African American men, 216.6 had prostate cancer compared with 123.9 out of 100,000 white men, according to data from the National Cancer Institute.

Dr. Linda Mermelstein. Photo from Stony Brook Medicine

Dr. Linda Mermelstein, Associate Director of Stony Brook Cancer Center’s Office for Community Outreach and Engagement, is working with her team to address those stark differences and to empower members of the community to protect their health and make informed decisions.

“A lot of our focus is on addressing disparities” in cancer care in various communities throughout Long Island, Dr. Mermelstein said. 

The Cancer Center Outreach and Engagement office has taken numerous steps to inform the public about research and care. The center has a Mobile Mammography Unit, which travels into communities to provide access to screening for breast cancer.

On June 5, at the Latina Sisters Support Inc. Spanish Fair in Brentwood, the Cancer Center’s Community Outreach and Engagement staff provided mobile mammography screening and cancer prevention and screening education.

At that event, the Suffolk County Department of Health Services provided human papillomavirus and Covid-19 vaccines and Stony Brook School of Health Professionals offered blood pressure screening.

An information chasm

Dr. Jedan Phillips. Photo from Stony Brook Medicine

Dr. Jedan Phillips, Medical Director for Stony Brook Health Outreach and Medical Education and Associate Professor of Family, Population and Preventive Medicine at the Renaissance School of Medicine, explained that Covid-19 exposed the “chasm” between what the health care profession believed and the reality of what works and what doesn’t.

During the pandemic, Stony Brook University brought a vaccination pod to Uniondale in Nassau County, which is a predominantly African American community. “Because we had no relationship there, we might have wasted over 200 doses of the vaccine” as residents were reluctant to get vaccinated, he said. “Even though [Stony Brook] offered something that would help, people chose against it. It’s not about the vaccine. It’s something deeper.”

Dr. Phillips said East Elmhurst, Queens, where he grew up, was “ravaged by Covid. I know at least 10 people in my community who were regular figures in my life that died. I saw how vulnerable of a position we were in as a group and I felt I needed to get involved.”

Dr. Phillips, who has a family medical practice in East Patchogue, together with Dr. Yuri Jadotte, Assistant Professor and Associate Program Director for the Preventive Medicine Residency in the Department of Family, Population and Preventive Medicine at Stony Brook, created three focus groups to survey the views and understanding of African American men on prostate cancer.

Many African American men don’t get screened for prostate cancer, even though such screenings could lead to earlier treatment and better outcomes.

By listening to what inspires African American men throughout Long Island to take action, Dr. Phillips hopes to tailor information to that type of delivery.

“It’s important to listen and understand,” Dr. Phillips said. Understanding what motivates people and seeking to provide the formats in which they prefer to access information can help establish a community connection and demonstrate cultural compassion.

Part of Dr. Phillips’s focus on preventive medicine comes from his experience with his father, who died from complications related to diabetes. His father, who was an inspiration for him, “didn’t live life in a preventive way,” which made managing his health more difficult, Dr. Phillips said.

With the numerous programs offered by the Office for Community Outreach and Engagement, Dr. Mermelstein said the group has four primary goals.

Dr. Jedan Phillips provides medical care.

“We want to monitor and understand what is the cancer burden in our catchment area” which includes Nassau and Suffolk County, she said. “Much of our activities are identifying the issues in terms of cancer” and understanding any barriers towards cancer care, like education, screening, diagnosis and treatment.

Secondly, she wants to provide cancer prevention services, screening, education and community navigation. Third, the group has a bi-directional engagement, with researchers getting to know the community and community advocates and the community learning about the research process.

Finally, the group seeks to catalyze the research by focusing on disparities, providing research services to the entire community based on specific needs.

One of Dr. Mermelstein’s first actions after heading up this team in 2019 was to create a community advisory council for the Stony Brook Cancer Center.

Janine Logan, Vice President of Communications and Population Health with the Long Island Health Collaborative, serves on that advisory council.“What I’m most excited about is that the committee understands the importance of knowing what your community thinks and needs,” Logan said.

Logan is pleased with the work the Stony Brook Cancer Center has done to educate residents about the lifestyle behaviors that can contribute to cancer, such as smoking, inactivity, and nutrition.

“They’ve done a lot of work in reaching out and educating communities to help them understand that these simple, modifiable behaviors can reduce their risk” of developing cancer, Logan said.

The effort at the Cancer Center to educate the public about the danger’s of the sun dovetails with some of the work she has done at the Long Island Health Collaborative.

Indeed, the Cancer Center Community Outreach and Engagement hosted a “Block the sun, not the fun” gathering on May 7 at the Smith Haven Mall in Lake Grove.

The Stony Brook Cancer Center is also working with the Suffolk County Department of Health Services Cancer Prevention and Health Promotion Coalition to provide information about sunscreen safety.

In addition to the disparity among African American men who develop prostate cancer, the outreach effort also addressed the difference among hispanic women who have a higher incidence of cervical cancer than the non-hispanic Caucasian population.

In Suffolk County, about 10.2 Hispanic and Latino women out of 100,000 Hispanic and Latino women develop cervical cancer, which is higher than the 5.9 per 100,000 for white, non-Hispanic women, according to the National Cancer Institute.

Human papillomarvirus is estimated to cause about 36,500 cases of cancer in men and women every year in the United States. The HPV vaccination, which works best before exposure to the virus, can prevent 33,700 of those cancers. Because the vaccine doesn’t prevent all cancers, women still need screening to protect themselves.

Previously employed for 22 years with the Suffolk County Department of Health Services, Dr. Mermelstein, who has a medical degree and a master’s in public health, briefly retired, before taking this job at Stony Brook.

“I wanted to do something to help address cancer after I retired, and so I contacted Stony Brook Cancer Center and began in this position about four months after I retired,” she explained.

Those interested in reaching out to the Office for Community Outreach and Engagement can call 631-444-4263 or email [email protected].

Paolo Boffetta. Photo by Jeanne Neville/Stony Brook Medicine

By Daniel Dunaief

Screening for cancer can help people take steps to head off the development of a disease that could threaten the quantity and quality of their lives.

During the start of the pandemic, people around the world stopped screening for cervical, breast and colorectal cancer, according to a recent study led by Paolo Boffetta, Associate Director for Population Sciences at Stony Brook University’s  Cancer Center.

The results of the study were recently published in the journal JAMA Oncology.

Compared to 2019, screenings for breast cancer dropped in the first few months after the start of the pandemic by 35.6 percent for breast cancer, 41.8 percent for colorectal cancer, and 54.1 percent for cervical cancer compared to the same period in 2019.

Paolo Boffetta. Photo by Jeanne Neville/Stony Brook Medicine

Boffetta chose these three cancers because they are the ones public health authorities recommend for the population at large. Screenings can improve patient outcomes. 

“For some/ most cancer, the earlier the better for detection,” explained Stony Brook Cancer Center Director Yusuf Hannun.

Boffetta, who is also Adjunct Professor at the Icahn School of Medicine at Mount Sinai in New York City, suggested that the longer-term impact of a reduction in screenings in the early part of the pandemic won’t be clear to doctors or patients in the short term.

“It will take a little bit of time to have a full understanding of this,” said Boffetta. Depending on the specific type, cancers “that are detected by screenings would not otherwise appear for a few years.”

Boffetta suggested that the pandemic, apart from the illnesses and symptoms that threatened the health of people who were battling the virus itself, affected public health services. He believes several factors likely contributed to the decrease in screenings. Patients around the world were reluctant or restricted in their ability to leave their homes amid lockdowns.

Additionally, some cancer centers likely reduce the number of people they monitored to cut back on the density of patients in health care facilities, although Boffetta did not gather any data on the reduction in the number of screenings at health care centers.

The positive news amid this study, which surveyed cancer screening data in PubMed and other medical journals from 19 countries from January 2020 through December 2021, was that the number of patients screened returned to a more normal level within several months of the start of the pandemic.

“An important finding is that by the summer of 2020, the decrease in screenings for breast cancer and cervical cancer seem to have disappeared,” Boffetta said by phone from Italy, where he is a part-time professor at the University of Bologna. “For colorectal cancer [the decrease in screenings] lasted longer,” through the end of 2020.

Boffetta described the reduction in screenings and then a return to normal as a U-shaped curve, with an initial decline followed by a recovery. Doctors typically screen for colorectal cancers by using a colonoscopy. This technique requires several hours in the hospital. Patients may have been “more reluctant to go back to such a complex procedure, compared to the mammography or pap smear” which screen for breast and cervical cancers, respectively.

Boffetta is conducting a broad study of the cancer literature from early findings to clinical diagnosis to treatment. At this point, he has finished a paper on the frequency and types of clinical diagnoses amid the pandemic. He is collecting data for another study that will examine cancer treatment.

“We are interested in how the pandemic affected each of these stages,” he said.

Hannun suggested that Boffetta’s work expertise help address important health care questions related to the pandemic and other threats to public health, adding, “Epidemiology is essential for understanding the pandemic and many chronic diseases, especially cancer with exposure issues.

A lab update

Boffetta joined Stony Brook University in April of 2020, soon after the start of the pandemic.

Also a Professor in the Department of Family, Population and Preventive medicine at the Renaissance School of Medicine at Stony Brook University, Boffetta will return to the United States in a few weeks from Italy.

Boffetta has added Research Coordinator Germana Giupponi and postdoctoral fellow Malak Khalifeh to his research efforts at Stony Brook. 

Germana Giupponi

A native of Italy, Giupponi, who started working with Boffetta in July of 2020 and provides administrative support and coordination with Boffetta’s collaborators, earned her master’s degree from the University of Milan.

Khalifeh joined Boffetta’s lab in March, is originally from Lebanon and conducted her PhD research in France at the University of Bordeaux. She is studying the link between the exposure people have to various chemicals in drinking water and bladder cancer. The bladder is especially susceptible to toxins from the environment.

Boffetta, meanwhile, has started teaching some graduate level classes at Stony Brook on cancer epidemiology for master’s and PhD students. He will teach one class this fall.

He is also continuing his studies with survivors of the World Trade Center attacks.

He has been comparing the survival of these first responders to the overall population in New York, comparing how the risk of cancer changed over the course of the 21 years since the attacks.

Boffetta has been working with Ben Luft, Director of the Stony Brook WTC Wellness Program at the Renaissance School of Medicine. Luft has provided clinical and research support for WTC responders.

Boffetta continues to have academic affiliations with other academic institutions, including Harvard University and Vanderbilt University.

Boffetta and his wife Antonella Greco, who have been living in New York City, plan to move to the Stony Brook area. Their three daughters live in Brooklyn, Italy and Argentina. Now that pandemic restrictions have lifted, Boffetta has been able to return to the opera and museums and has done some skiing and hiking.

As for this study, Boffetta suggested that the findings about screenings were consistent with what he might have expected during the beginning of the pandemic.Delaying screenings could mean that some people discover cancers at a more advanced state by the time they diagnose them, he said.

Latoya Bazmore and Devon Toney, co-founders of All Included ’N’ Treated (A.I.N.T.), near Ross Memorial Park in Brentwood. Photo by Raymond Janis

After serving out a 17-year state prison sentence, Devon Toney returned to society unprepared for the challenges ahead.

Toney described parole as just another pressurized situation in a string of high-pressure environments that he has experienced since childhood. Parole, he said, only aggravated his post-traumatic stress disorder, stymying any opportunities for upward growth. 

He soon entered the shelter system in Suffolk County, traveling between homeless shelters and health care facilities, his most recent stay at The Linkage Center in Huntington. Eventually, feeling suffocated in the shelters and unable to sleep among strangers, he left that system for a life on the streets. By night, he slept in train stations, bus stations, dugouts and public parks. By day, he stole, often reselling juices and water just to get by. 

Without adequate resources and a lack of attention, Toney said those experiencing homelessness “have to steal,” that life on the streets “causes clean people — healthy people — to become addicts because that’s all they’re around.”

Toney remains homeless to the present day, currently residing near Ross Memorial Park in Brentwood. His story is one of countless examples of how easily one can become homeless after giving up on shelter, falling through the cracks with few opportunities to rise above these dire circumstances.

‘It’s probably one of the most difficult and complex moral and legal issues that I deal with.’

— Jonathan Kornreich

A startling trend

Mike Giuffrida, associate director of the Long Island Coalition for the Homeless, a nonprofit that works throughout Long Island to determine better strategies and policies to address homelessness, said he has noticed a recent trend of others fleeing from shelters.

“Although emergency shelter is available to the majority of people who present as having nowhere else to go, we are seeing an increased rate of individuals who are presenting as unsheltered and are living on the street,” he said.

Motivating this shelter shock, Giuffrida sees two principal factors: “The greatest commonality of people that experience homelessness is … significant trauma, likely throughout the majority — if not all — of their lives,” he said. The second factor is the structure of the shelter system, which is constrained by strict guidelines from New York State and “can be retraumatizing for people or the shelter settings do not meet their needs.”

An aversion to communal living is commonplace among those requesting emergency shelter. In addition, occupants of these shelters are often asked to give up considerable portions of their income for shelter payments. “They pay, in some cases, almost all of their income in order to stay in that undesirable location,” Giuffrida said. 

Clusters of homeless encampments can be found in areas throughout Suffolk County. Brookhaven Town Councilmember Jonathan Kornreich (D-Stony Brook) says there are likely dozens of individuals experiencing homelessness in his council district alone, concentrated primarily in Port Jefferson Station. 

Kornreich complained about how he is limited in his capacity to help, saying he wishes that he could do more. “It’s probably one of the most difficult and complex moral and legal issues that I deal with,” he said. “The Town of Brookhaven doesn’t have any functions with respect to social services or enforcement, but because this is an area of concern to me, I try to identify people who might be in need of services and try to either talk to people myself or put them in touch with services.” 

Those services are provided through the Suffolk County Department of Social Services. In an emailed statement, a spokesperson affiliated with DSS outlined the array of options that are available through the department.

“The Suffolk County Department of Social Services offers temporary housing assistance, in shelter settings, to eligible individuals and families experiencing homelessness,” the spokesperson said. “We contract with nonprofit agencies that provide case management services to each client based on their individual needs, with a focus on housing support. Services may include referrals to community agencies, mental health programs, as well as medical services. These services, with the support and encouragement of shelter staff, work in concert to transition those experiencing homelessness to appropriate permanent housing resources.”

In an interview, County Executive Steve Bellone (D) said the COVID-19 pandemic and nationwide economic challenges have only exacerbated the conditions of homelessness throughout the county. Despite external barriers, he holds that there is room for improvement.

“More could always be done, of course,” he said. “We are — as I’ve said many times before — coming out of COVID and grappling with impacts and effects that we’re going to be dealing with for years to come and that we don’t fully understand yet.” He added, “The Department of Social Services has, throughout COVID, and as we’ve started to move out of that now, worked very hard to fulfill its mission and will continue to do that.”

‘The frustrating part is that we are limited… We are limited in forcing a person to get medical treatment.’

— Sarah Anker

Accepting services: A two-way street

Suffolk County Legislator Sarah Anker (D-Mount Sinai) detailed the decades-long history of homelessness in Coram. She argues that it is closely tied to other pressing matters facing county government: public safety, access to health care, the opioid epidemic and inadequate compensation for social workers. 

The county legislator also blamed stringent state guidelines that handicap DSS’s outreach efforts. “The frustrating part is that we are limited,” Anker said. “We are limited in forcing a person to get medical treatment.”

Legislator Nick Caracappa (C-Selden), the majority leader of the county Legislature, voiced similar frustrations. He said he is concerned by the growing number of people that reject services from DSS.

“Even though you offer them help, you offer them shelter, and you offer them medical [assistance], they often turn it down,” he said. “They’d rather be out in the cold, alone, in the dark — whatever it is — than seek help. And that’s concerning.”

Emily Murphy, a licensed social worker who wrote a thesis paper investigating homelessness in Port Jefferson Station, said another significant problem is the lack of assistance for undocumented immigrants, whose immigration status bars them from applying for services.

“It’s not a DSS decision, but it comes from higher up, that if you don’t have documentation you can’t receive SNAP [Supplemental Nutrition Assistance Program] benefits or shelter,” Murphy said.

This changes during the colder months, according to Murphy, as shelters open their doors to all. Murphy also observed how a lack of political mobilization hampers the homeless community from receiving adequate government representation.

“That was the main thing,” Murphy said, referring to the homeless population. “It was a voice that was so often unheard and unlistened to.”

The gradual downward slope

Joel Blau, professor emeritus of the School of Social Welfare at Stony Brook University, has followed trends in homelessness for decades. He attributes rising homelessness in the United States since the 1970s to the stagnation of wages across that time frame coupled with the rising cost of housing.

“The notion of somebody with a high school education maintaining a decent standard of living is becoming ever more elusive,” he said. “Housing prices, particularly in cities, have escalated a lot, so unless you have two professionals in the family or one person who makes a lot of money, it’s increasingly difficult to get decent housing.” 

Today, a growing number of people are just one step away from losing their homes. “Whether it be an accident or an illness or the loss of a job, all of a sudden they’re plummeting downward and onto the street,” he said.

Evaluating long-term projections of homelessness, Blau said there have been “periods where it plateaus and periods where it gets worse.” On the whole, he said, “the general trend is downward.”

Blau believes the way to remedy the issue is to change the ways in which society is organized. “It would require social housing, decommodifying it so that housing is a right, not something sold for profit,” he said. “And that’s probably, under the present political circumstances, a bridge too far.” In other words, problems associated with homelessness in this country have grown for many years and are likely to continue.

‘We need to let them know that we love and we care about them.’ — Devon Toney

Resurrection: A reason to hope

Toney has partnered with Latoya Bazmore, also of Brentwood, to create A.I.N.T. (All Included ’N’ Treated), a grassroots organization to combat homelessness in the community. 

Toney said his primary goal is to access adequate housing. After that, he intends to galvanize his peers in the community, serving as a beacon for those who are also going through the struggle of homelessness. As someone who has experienced homelessness firsthand and who can relate to the plight, Toney believes he is uniquely situated to be an agent of change and a force of good.

“I need to be the one that interacts with these gang members, these addicts … they need somebody to articulate things to them,” he said. “We need to comfort them. We need to let them know that we love and we care about them.”

To learn more about the A.I.N.T. project, please visit the AIN’T (all included N Treated) Facebook page or visit the group on Instagram: @all.included.and.treated.

Dr. Peter Igarashi is the incoming dean of the Renaissance School of Medicine. Photo from University of Minnesota

Stony Brook University’s Renaissance School of Medicine has named Dr. Peter Igarashi, a nephrologist and physician scientist, as its new dean, effective Sept. 12.

Igarashi comes to Stony Brook from the University of Minnesota Medical School, where he is the Nesbitt Chair, professor and head of the Department of Medicine.

At the University of Minnesota, the new dean oversaw 600 full-time and affiliate faculty, 100 adjunct faculty, and over 240 residents and fellows, all while increasing National Institutes of Health funding by 60%.

At UMN, he also helped to cut gender pay disparities, appointed women to leadership positions, developed new multidisciplinary programs, and created an Office of Faculty Affairs and Diversity.

“Dr. Igarashi is a superb, academically accomplished physician leader with a highly successful track record of clinical program growth and research advancement,” Dr. Hal Paz, executive vice president of Health Sciences at SBU and chief executive officer of Stony Brook University Medicine, said in a statement. 

Igarashi has received over $25 million in funding from the NIH during a career in which he has studied polycystic kidney disease, transcriptional regulation, epigenetics and kidney development.

Polycystic kidney disease, or PKD, is an inherited disorder that involves the development of clusters of cysts, primarily in the kidney. Symptoms of the disease can include high blood pressure, loss of kidney function, chronic pain and the growth of cysts in the liver, among others.

His lab developed unique lines of transgenic mice that he has used to study kidney-specific transgene expression and gene targeting.

In addition to writing nine chapters in textbooks, Dr. Igarashi has also authored more than 100 peer-reviewed journal articles.

Before his seven-year stint at the University of Minnesota, Dr. Igarashi had been Chief of the Division of Nephrology and founding director of the O’Brien Kidney Research Core Center at the University of Texas Southwestern Medical Center in Dallas.

At the University of Texas, Dr. Igarashi created services to provide regular kidney dialysis to undocumented and other often marginalized patients. He also led an effort to use artificial intelligence to identify and optimize co-management of patients with hypertension, diabetes, and chronic kidney disease in primary care practices.

A recipient of the NIH Merit Award, Dr. Igarashi also won the 2015 Lillian Jean Kaplan International Prize in polycystic kidney disease. The award honored his contribution to the goal of developing treatments and a cure for polycystic kidney disease.

Dr. Igarashi earned his medical degree from the UCLA School of Medicine and completed an internal medicine residency at the University of California Davis Medical Center. He did a nephrology fellowship at Yale University and also taught at the Yale University School of Medicine.

Dr. Igarashi is board-certified by the American Board of Internal Medicine. He is a member of the American Heart Association Kidney Council, the American Physiological Society, the American Society for Clinical Investigation, the American Society of Nephrology and the Association of American Physicians.

Dr. William Wertheim had been the interim dean of the Renaissance School of Medicine since February 2021, following Dr. Kenneth Kaushansky’s retirement after serving as dean and senior vice president of health sciences for 11 years.

Dr. Wertheim will return to his role as vice dean for graduate medical education. He will also have a leadership role at the Stony Brook Medicine Community Medical Group, which is an arm of Stony Brook Medicine and includes over 35 community practices with over 50 locations across Long Island.

The SK 48 cranium of an ancient hominin, Paranthropus robustus, was one of the fossils included in the analysis of some new claims on human evolution. Photo by Carrie S. Mongle

Uncovering the evolution of any set of living creatures is a complex and highly detailed task for scientists, and theories and approaches that may differ over time may indeed change the fossil record. But paleoanthropologist and Stony Brook University Professor Carrie S. Mongle, PhD, and co-authors urge investigators to take caution on their findings. They provide researchers investigating the evolutionary past of ancient hominins (a group including humans and our immediate fossil ancestors) an important and foundational message in a recent paper published in Nature Ecology & Evolution. That is – conclusions drawn from evolutionary models are only as good as the data upon which they are based.

In “Modelling hominin evolution requires accurate hominin data,” the authors develop a response to a previous research paper that had made some major claims on when the genus Homo emerged based on fossil dates. The team, however, proved that many of the fossil dates from the study were wrong, and they provided data to correct these errors.

“It has become increasingly common in our field for researchers to propose a ‘new and exciting’ synthesis of evolutionary events that a given group of scientists think overturns our understanding of human evolution,” says Mongle, Assistant Professor in the Department of Anthropology and Turkana Basin Institute. “Our paper is meant to draw attention to the issue that we cannot make major claims based on piecemeal compilations of the fossil record and questionable data from literature. We also offer a carefully constrained geochronological dataset for researchers to use for future studies.”

Mongle and co-authors found that by re-analyzing the original study with corrected fossil dates, the estimated timing of species divergences differed by as much as 300,000 years from the previously reported estimates. This is important because these estimates are often used to correlate evolutionary transitions with ancient environments and climate change. When estimates are off by this much, it can completely change scientists’ interpretations of the evolutionary drivers that made us human.

Mongle and co-authors make the case for evolutionary scientists to develop future total evidence studies when studying human evolution. They conclude that it is “critical to recognize that no algorithm is a replacement for careful comparative anatomy and meticulously constrained geochronology when it comes to interpreting evolutionary trends from the fossil record.”

Markus Seeliger, third from left, with members of his lab, from left, Terrence Jiang. Aziz Rangwala, Ian Outhwaite, Victoria Mingione,YiTing Paung, and Hannah Philipose. Photo from Markus Seeliger

By Daniel Dunaief

When a dart hits the center of a target, the contestant often gets excited and adds points to a score. But what if that well-placed dart slipped off the board before someone could count the points, rendering such an accurate throw ineffective?

With some cases of cancer treatments, that’s what may be happening, particularly when a disease develops a mutation that causes a relapse. Indeed, people who have chronic myeloid leukemia typically receive a treatment called Imatinib, or Gleevac.

The drug works, hitting a target called a kinase, which this white blood cell cancer needs to cause its cells to continue to divide uncontrollably. Patients, however, develop a mutation called N368S, which reduces the effectiveness of the drug.

While mutations typically make it more difficult for a drug to bind to its target, that’s not what’s happening with this specific mutation. Like the dart hitting the center of a board, the drug continues to reach its target.

Instead, in a model of drug resistance several scientists have developed, the mutation causes the drug to decouple.

Pratyush Tiwary with this year’s US top 20 students who are going to the international chemistry olympiad. Photo from Toward

A team of experimental and computational researchers including Markus Seeliger, Associate Professor of Pharmacological Sciences at Stony Brook University, and Pratyush Tiwary, Associate Professor in the Department of Chemistry & Biochemistry at the University of Maryland, published two research papers explaining a process that may also affect the way mutations enable resistance to other drugs.

Seeliger described how different disease-associated mutations bind to Gleevac in a paper published in the Proceedings of the National Academy of Sciences. 

Working with scientists at Memorial Sloan Kettering Cancer Center and Goethe University in Frankfurt, Germany, Seeliger used nuclear magnetic resonance spectroscopy, or NMR. The researchers showed how the drug bound to its target and then released.

Understanding the way diseases like cancer develop such resistance could affect drug discovery, giving pharmaceutical companies another way to prepare for changes diseases make that reduce the effectiveness of treatments.

A ‘hot paper’

Tiwary published research in which Seeliger was a coauthor in late April in the journal Angewandte Chemie that the publication labeled a “hot paper” for its implications in the field. Tiwary developed a way to simulate the kinetic processes that enable the mutated kinases to release the drug.

Tiwary created an artificial intelligence model that extended the time he analyzed the drug-protein interaction from milliseconds all the way out to thousands of seconds.

“Even within the simulation world, if you can quantitatively predict a binding affinity, that’s amazing,” Seeliger said. “It’s extremely hard to calculate kinetics, and he got that right.”

Tiwary, who started talking with Seeliger about five years ago and has been actively collaborating for about three years, uses experimental data to inform the dynamics that affect his simulations.

Seeliger “had done the experiments of the dissociation rates beforehand, but did not have a way to explain why they were what they were,” Tiwary explained in an email. “Our simulations gave him insights into why this was the case and … insight into how to think about drugs that might dissociate further.”

Drug discovery

Tiwary hopes the work enables researchers to look at structural and kinetic intermediates in reactions, which could provide clues about drug design and delivery. While he worked with a single mutation, he said he could conduct such an analysis on alterations that affect drug interactions in other diseases.

He wrote that the computations, while expensive, were not prohibitive. He used the equivalent of 16 independent 64 CPUs for one to two weeks. He suggested that computing advances could cut this down by a factor of 10, which would enable the exploration of different mutations.

“The methods are now so easy to automate that we could run many, many simulations in parallel,” Tiwary explained. Machine learning makes the automation possible.

Given what he’s learned, Tiwary hopes to contribute to future drug begin that addresses mutation or resistance to treatment in other cancers. He also plans to continue to work with Seeliger to address other questions.

Next steps

Seeliger said he plans to extend this work beyond the realm of this specific type of cancer.

He will explore “how common these kinetic mutations are in other systems, other diseases and other kinases,” Seeliger said.

He would also like to understand whether other proteins in the cell help with the release of drugs or, alternatively, prevent the release of drugs from their target. The cell could have “other accessory proteins that help kick out the drug from the receptor,” Seeliger said.

The concept of drug resistance time comes from infectious disease, where microbes develop numerous mutations.

Seeliger, who is originally from Hanover, Germany, said he enjoys seeing details in any scene, even outside work, that others might not notice. 

He described how he was driving with postdoctoral fellows in Colorado when he spotted a moose. While the group stopped to take a picture, he noticed that the moose had an ear tag, which is something others didn’t immediately notice.

As for the research collaboration, Seeliger is pleased with the findings and the potential of the ongoing collaboration between experimental and computational biologists.

“The computational paper, aside from using interesting new methodology, describes why things are happening the way they are on a molecular level,” he said.

Study authors Liwei Yang, left, and Jun Wang, in the Wang laboratory by the microscope that incorporates the single-cell cyclic multiplex in situ tagging (CycMIST) technology to analyze proteins on single cells. Photo provided by Jun Wang

A new biomedical research tool that enables scientists to measure hundreds of functional proteins in a single cell could offer new insights into cell machinery. Led by Jun Wang, Associate Professor of Biomedical Engineering at Stony Brook University, this microchip assay — called the single-cell cyclic multiplex in situ tagging (CycMIST) technology – may help to advance fields such as molecular diagnostics and drug discovery. Details about the cyclic microchip assay method are published in  Nature Communications.

While newer technologies of single-cell omics (ie, genomics, transcriptomics, etc.) are revolutionizing the study of complex biological and cellular systems and scientists can analyze genome-wide sequences of individual cells, these technologies do not apply to proteins because they are not amplifiable like DNAs. Thus, protein analysis in single cells has not reached large-scale experimentation. Because proteins represent cell functions and biomarkers for cell types and disease diagnosis, further analysis on a single-cell basis is needed.

“The CycMIST assay enables comprehensive evaluation of cellular functions and physiological status by examining 100 times more protein types than conventional immunofluorescence staining, which is a distinctive feature not achievable by any other similar technology,” explains Liwei Yang, lead author of the study and a postdoctoral scholar within the Wang research team and Multiplex Biotechnology Laboratory.

Wang, who is affiliated with the Renaissance School of Medicine and Stony Brook Cancer Center, and colleagues demonstrated CycMIST by detecting 182 proteins that include surface markers, neuron function proteins, neurodegeneration markers, signaling pathway proteins and transcription factors. They used a model of Alzheimer’s Disease (AD) in mice to validate the technology and method.

By analyzing the 182 proteins with CycMIST, they were able to perform a functional protein analysis that revealed the deep heterogeneity of brain cells, distinguished AD markers, and identified AD pathogenesis mechanisms.

With this detailed way to unravel proteins in the AD model, the team suggests that such functional protein analysis could be promising for new drug targets for AD, for which there is not yet an effective treatment. And they provide a landscape of potential drug targets at the cellular level from the CycMIST protein analysis.

The authors believe that CycMIST could also have enormous potential for commercialization.

They say that before this study model with CycMIST, researchers could only measure and know a tip of protein types in a cell. But this new approach enables scientists to identify and know the actions of each aspect of a cell, and therefore they can potentially identify if a cell is in a disease status or not – the first step in a possible way to diagnose disease by analyzing a single protein cell. And compared with standard approaches like flow cytometry, their approach with CycMIST can analyze 10 times the amount of proteins and on a single-cell level.

The researchers also suggest that the cyclic microchip assay is portable, inexpensive, and could be adapted to any existing fluorescence microscope, which are additional reasons for its marketability if it proves to be effective with subsequent experimentation.

Much of the research for this study was supported by the National Institutes of Health’s National Institute of Aging (grant # R21AG072076), other NIH grants, and a Memorial Sloan Kettering Cancer Center Support Grant.

Photo from Stony Brook Medicine

The Stony Brook Medicine Mobile Mammography Van will provide screenings for breast cancer for women 40 and older from 10 a.m. to 2 p.m. Friday, July 8, at St. Anthony of Padua Church in East Northport. The van will be parked at 1025 Fifth Ave. in East Northport, outside the church’s Parish Outreach office.

Screenings are provided by state-registered radiologic technologists trained in mammography. The van has a comfortable waiting area, private dressing room and a complete exam room. Individuals without insurance are processed through the Cancer Services Program of New York, if eligible. 

Call 631-638-4135 for eligibility details and to register.

Catherine Deneuve and Benoît Magimel in a scene from Peaceful. Photo courtesy of Staller Center

Stony Brook University’s Staller Center  for the Arts turns into a movie lover’s mecca when new independent films screen at the Stony Brook Film Festival on evenings and weekends from Thursday, July 21 to Saturday, July 30. The popular festival, now in its 27th year, pairs memorable short films with an array of features you won’t see anywhere else, making it a favorite of moviegoers and filmmakers alike.

Presented by Island Federal, the 2022 Festival lineup offers 38 films from over 28 countries. The Festival kicks off with the North American premiere of Peaceful, starring Catherine Deneuve, Benoît Magimel, and Gabriel A. Sara. A life-affirming drama about acceptance and resilience, Peaceful follows Benjamin, an acting teacher with a terminal illness as he navigates his final months and days. The beating heart of the film comes from Gabriel Sara — a cancer specialist from Mount Sinai Hospital in Manhattan in real-life — who portrays Benjamin’s very humane specialist Dr. Eddé. Catherine Deneuve’s powerful performance as Benjamin’s mother is unforgettable.

“This year’s Festival is somewhat of a family affair, with several real-life family members making films, and members of our Stony Brook family returning,” says Festival co-programmer Kent Marks. “Our Sunday night independent feature, the very touching This is a Film About My Mother, which was shot in Ithaca, New York, stars real-life siblings Tess and Will Harrison and was written and directed by Tess.”

The theme of family continues with the mesmerizing Korean independent film, Seokkarae. Written and directed by Mike Beech, and starring his wife, Jiwon Lee, the character-driven film depicts a quiet twenty-something attempting to keep the family business going despite tough odds. Jungle is another such collaboration, written by real life partners Claudia Verena Hruschka and Kieran Wheeler, with Wheeler directing and Hruschka giving a gut-wrenching performance in this hard-hitting short from Australia. 

From Australia to Stony Brook, The Switcheroo is co-directed by Stony Brook brothers Ryan and Anthony Famulari. Made for next to nothing during COVID, this hilarious comedy has the brothers serving as the entire crew, with Anthony cast in the very funny role of a man and his clone. Two more co-directors are sisters Austin and Westin Ray with their UK-based quiet thriller Before Seven. The Ray’s, Festival alums from 2014, served as directors, writer (Westin) and composer and cinematographer (Austin). Another SBFF festival alum is John Gray, who won the audience choice award for his 2020 film Extra Innings, and is back this year with the intriguing family drama The Little Drummer Boy.

Women will take center stage at this year’s SBFF, both in front of and behind the camera. SBFF’s opening and closing night features and shorts were all helmed by female directors. In all, 17 of the Festival’s 38 films were directed by women. Two films, Kitchen Tales and Before Seven, were made with nearly all-female crews. 

The Jackie Stiles Story and Nasima are two completely different documentaries about female athletes from the middle of nowhere — a small Kansas town and a small seaside village in Bangladesh — who both beat the odds and made a huge impact in their respective sports of basketball and surfing. 

There are heroines from all walks of life, whether in the New Zealand drama The Justice of Bunny King, the Israeli epic Image of Victory, the Albanian thriller Vera Dream of the Sea, or the American indie Peace in the Valley, all of which feature knock-out performances by their lead actresses.

Reflecting on current issues, two films in the Festival, Olga and Berenshtein both take place in and around Ukraine, and both are from times when the Ukrainian people faced down an oppressive regime — whether it be from the Nazis or their own government.

Mila, a must-see short film on SBFF’s closing night, is a debut effort by writer/director Cinzia Angelini and made by 350 animators from 35 countries, who volunteered their services to help Angelini get her story made after all major studios turned it down. Inspired by events of the 1943 Trento bombing in Italy, this heart-warming story depicts a young girl who has lost everything but still clings to hope. 

The closing night feature, Lost Transport, is a powerful and deeply moving film set during the final days of World War II, uniquely told from a female perspective. When German soldiers abandon a deportation train, leaving the fate of its occupants in the hands of advancing Russian troops, three women from vastly different backgrounds, set aside their differences, working together to survive.

“The diversity of filmmakers is a hallmark of Stony Brook Film Festival, with student filmmakers, seasoned pros, and nine first-time directors represented this year,” says Festival Director Alan Inkles. “We are very excited to have filmmakers from all over the world join us in-person this year for their premiere screenings. Our audience can gather in a huge theater with Long Island’s largest screen, to see movies the way they were meant to be seen. Not only are these films not available on any streaming format, but you also get to hear directly from the filmmakers themselves, ask them a question at our live Q&A, and even vote for your favorite.”

For 27 years, the Stony Brook Film Festival has hosted 549 filmmakers from 78 different countries, featured nearly 55 World Premieres and over 75 U.S. premieres. In total, the Festival has screened almost 1100 independent films from all over the world. The Festival kicks-off with an Opening Night Party and closes with an Awards Ceremony and Closing Night Party.

FILM SCHEDULE

OPENING NIGHT

Thursday, July 21 at 8 p.m.

Feature: Peaceful, France

Short: Lentini, United States

 

Friday, July 22 at 7 p.m.

Feature: Olga, Switzerland, Ukraine,  France

Short: Kitchen Tales, United Kingdom

 

Friday, July 22 at 9:30 p.m.

Feature: Glob Lessons, United States

Short: Before Seven, United States

 

Saturday, July 23 at 4:30 p.m.

Doc Feature: The Jackie Stiles Story, U.S.

 

Saturday, July 23 at 7 p.m.

Feature: Contra, Germany

Short: The Little Drummer Boy, U.S.

 

Saturday, July 23 at 9:30 p.m.

Feature: Peace in the Valley, U.S.

Short: Elevate, United States

 

Sunday, July 24 at 4:30 p.m.

Documentary Feature: Nasima, U.S.

 

Sunday, July 24 at 7 p.m.

Feature: Berenshtein, Israel & Ukraine

Short: The Switcheroo, United States

 

Sunday, July 24 at 9:30 p.m.

Feature: This is a Film About My Mother, U.S.

Short: North Star, United States

 

Monday, July 25 at 7 p.m.

Feature: Hit the Road, Iran

Short: Summer of Bees, Finland

 

Monday, July 25 at 9:30 p.m.

Feature: Seokkarae, Korea

Short: Saving Elodie, United Kingdom

 

Tuesday, July 26 at 7 p.m.

Feature: Hard Shell, Soft Shell, France

Short: Almost Winter, United States

 

Tuesday, July 26 at 9:30 p.m.

Feature: The Justice of Bunny King, NZ

Short: The Dress, United States

 

Wednesday, July 27 at 7 p.m.

Feature: Image of Victory, Israel

Short: Milk, United Kingdom

 

Wednesday, July 27 at 9:30 p.m.

Feature: The Test, France

Short: Free Fall, France

 

Thursday, July 28 at 7 p.m.

Feature: Haute Couture, France

Short: Jungle, Australia

 

Thursday, July 28 at 9:30 p.m.

Feature: Sons of the Sea, South Africa

Short: Ousmane, Canada

 

Friday, July 29 at 7 p.m.

Feature: Vera Dream of the Sea, Kosovo & Albania & Republic of Macedonia

Short: All that Glitters, United Kingdom

 

Friday, July 29 at 9:30 p.m.

Feature: Black Box, France & Belgium

Short: Aysha, Germany

 

CLOSING NIGHT

Saturday, July 30 at 8 p.m.

Feature: Lost Transport, Netherlands & Luxemborg & Germany

Short: Mila, United States

 

CLOSING NIGHT AWARDS

10:30 p.m.

Ticket information

All screenings are held at Stony Brook University’s Staller Center for the Arts, 100 Nicolls Road, Stony Brook in the 1,000-seat Main Stage theater. Festival goers can choose from a Gold Pass, Festival Pass, or Individual Pass. Passes start at $20. All passholders will hear from filmmakers throughout the Festival and have the opportunity to rate and vote on favorite films to help choose the winners of this year’s Festival. 

Gold Passholders receive entry to all films, VIP reserved seating, a Stony Brook Film Festival swag bag, discounts at local restaurants and businesses, access to Opening and Closing Night After Parties, filmmaker Q&A’s, and the Closing Night Awards Ceremony. Festival Passholders receive entry to all films and guaranteed seating for sold-out films, filmmaker Q&A’s, access to the Closing Night Awards Ceremony, discounts at local restaurants and businesses, voting for Audience Choice Award, and a Stony Brook Film Festival Passholder gift. For more information or to order, call 631-632-2787 or visit stonybrookfilmfestival.com.

*This article originally appeared in TBR News Media’s Summer Times supplement on June 24.