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Peter Igarashi

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At the Milestones in Microbiology ceremony, standing alongside the Department’s commemorative plaque and a NYS Assembly Proclamation, are, from left: Theresa Koehler, ASM President; Carol Carter, Eckard Wimmer, David Thanassi, Jorge Benach; and Lorraine Findlay, from the ASM Committee on the History of Microbiology and Archives. Photo by Constance Brukin Photography

ASM honors the Department for its decades of work against infectious diseases

The Department of Microbiology and Immunology in the Renaissance School of Medicine (RSOM) at Stony Brook University was named a “Milestones in Microbiology” site for its advancements in the diagnosis and treatment of infectious diseases globally. The designation by the American Society for Microbiology (ASM) recognizes academic and research programs in which “major developments and pivotal discoveries occurred.”

The RSOM Department is only the 20th program nationally to receive this distinction, the third in New York State and second on Long Island. Faculty from the Department and University gathered at a Wang Center Ceremony at Stony Brook University on October 17 to commemorate the honor. They received a plaque from the ASM that commemorates the outstanding research and discoveries by the Department at large, since its inception at Stony Brook in 1972.

“The designation of the Department of Microbiology and Immunology as a Milestones in Microbiology Site is an honor and recognizes the impact the Department has made through its groundbreaking discoveries,” said David Thanassi, PhD, the Zhang Family Endowed Chair of the Department of Microbiology and Immunology. “This distinction not only reinforces the significant contributions of our former and current faculty, students and staff, but also raises the profile of the Department and University to the wider scientific community.”

“ASM is delighted to recognize Stony Brook University’s Department of Microbiology and Immunology as a ‘Milestones in Microbiology’ site for its significant contributions to the microbial sciences,” said Theresa Koehler, PhD, ASM President. “The university’s pioneering work investigating causative agents of human diseases have had far-reaching impacts in the sciences and society at large.” 

The Department was awarded the Milestones distinction for its broad research and many discoveries. Specifically, the ASM recognized the following accomplishments:

  • The landmark discovery by Founding Department Chair Joseph Kates, PhD, that viruses could package enzymes required for their replication, with the first demonstration of the vaccinia virus encapsulating the DNA-dependent RNA polymerase enzyme. This laid the groundwork for targeting viral polymerases as a widespread therapeutic strategy.

 

  • The discovery of Borrelia burgdorferi, the causative agent of Lyme disease, by Jorge Benach, PhD and colleagues, along with its isolation from patients and characterization of its environmental reservoir, paved the way for successful antibiotic therapies.

 

  • The first description of the de-novo chemical-biochemical synthesis of a virus (poliovirus) in the absence of a natural template by Dr. Eckard Wimmer and the co-discovery of the human receptor of polio virus. This marked the beginning of the total synthesis of microorganisms in the absence of natural templates, enabling new strategies in virus vaccine development.

 

“As a member of the faculty for several decades, it has been inspiring to witness the emergence of ideas and findings in which the outcomes have had such tremendous impact,” said Carol Carter, PhD, Distinguished Professor in the Department of Microbiology and Immunology. “Over the years, I have worked with incredible colleagues, students and supporting staff.”

Five decades impacting infectious disease discovery 

 In addition to the highlighted research of Drs. Kates, Wimmer and Benach, the Department during its five decades made other groundbreaking discoveries. These include pioneering work in molecular biology on the structure of DNA and regulatory mechanisms of RNA, foreshadowing research by others leading to the Nobel prize this year on the role of regulatory RNAs in eukaryotic cells.

The Department has contributed major findings related to tumor formation and cancer, and has long been a leader in research on pathogenic viruses, bacteria and fungi, revealing how these organisms cause infections and interact with our immune defenses. This research has yielded fundamental biological insights and provided a foundation for the development of therapeutics for the prevention and treatment of disease.

Some of the more recent work impacting the world of infectious diseases includes the role of how cancer-causing herpesviruses manipulate the host to establish life-long infections, advancing the understanding of Adenovirus replication, and unraveling the structure of bacterial appendages that enable kidney infections.

“Although the Milestones in Microbiology designation commemorates past accomplishments, it also sets the stage for future innovations and motivates the Department to keep pushing boundaries, pursue new questions, and lead the way in solving the challenges of tomorrow,”  said Peter Igarashi, MD, the Knapp Dean of the RSOM, who pointed out that the Department has had consistently strong funding success, including 17 grants totaling more than $8 million in funding from the National Institutes of Health in fiscal year 2024.

During the ceremony the department also received a Certificate of Recognition, a Proclamation by New York State Assemblyman Hon. Ed Flood. 

For more about the ASM Milestones Program and list of other awarded institutions nationally see this link.

The Department of Microbiology and Immunology is one of 25 departments within the RSOM. It is dedicated to advancing the knowledge of the fundamental causes, means of prevention and treatment of human diseases, and to educating the next generation of scientific investigators in infectious diseases and related fields. For more see this link.

 

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Dr. Susan Hedayati, right, and Dr. Peter Igarashi attend the ASCI/AAP meeting in Chicago Spring 2023. Photo courtesy Hedayati

She is bringing two important parts of an effective team back together.

Dr. Susan Hedayati — pronounced heh-DYE-it-tee — recently joined the Renaissance School of Medicine at Stony Brook University as vice dean for research. Hedayati was most recently a professor of medicine and associate vice chair for research at the University of Texas Southwestern Medical Center.

Hedayati plans to help improve Stony Brook Medical School’s national and international reputation by coupling frontline research with translational and patient-oriented care and studies.

The combination of a research and clinical care focus will provide for the “betterment of the health of Long Island population of patients,” Hedayati said.

In addition to enhancing clinical care, such an approach would “facilitate funding of investigator-initiated [National Institute of Health] grants and aid in the recruitment and retention of excellent M.D.-investigators,” she explained in an email.

She said she is eager to build an institutional clinical trials infrastructure that would involve a dedicated research support team.

Adding Hedayati to the medical school faculty at Stony Brook University, where she will also serve as the Lina Obeid chair in biomedical sciences, also brings two prominent kidney specialists who have different approaches to their work back together again.

Dr. Peter Igarashi, dean of the Renaissance School of Medicine and a nationally recognized nephrologist, had recruited and collaborated with Hedayati when she joined the University of Texas Southwestern Medical Center after winning first place in a clinical research award at the Southern Society for Clinical Investigation Young Investigator Forum.

When Igarashi first met Hedayati as a judge of the fellowship competition, he suggested that her expertise stood out clearly.

“She has enormous content expertise in the field of nephrology and internal medicine more broadly,” he said.

He was also impressed with her “passion” for research and her “devotion to patients and research,” which has also made her a “perfect fit” for her current position at Stony Brook University.

Combining research and clinical care will enable SBU to provide one-stop shopping at facilities like the specialty practices in Commack and the one recently opened in Lake Grove in the former Sears building at the Smith Haven Mall, he said.

Patients can receive clinical care at the same time that they can enroll in clinical trials for potential treatments of some conditions.

Hedayati “set that up at the University of Texas at Southwestern, and I’m hoping she’ll be able to grow that capability here,” Igarashi said.

Igarashi also described Hedayati, who was offered the job after a committee conducted the search, as “personable and likable.”

Complementary strengths

Igarashi described the different research approaches he and Hedayati take as “complementary” strengths.

Igarashi’s research is basic, wet lab science, while Hedayati has focused on translational and clinical research.

Their backgrounds will “be very helpful for elevating the entire research enterprise, not only in basic science but also in clinical and translational research,” Igarashi noted.

For her part, Hedayati suggested that her short-term goal is to build the physical infrastructure for clinical research and clinical trials.

Such efforts will require a clinical research staff infrastructure composed of research coordinators, research managers, regulatory personnel and biostatisticians.

“I’m hoping that, within a year, we’re going to be making some big strides in those directions,” Hedayati said.

She also hopes to build upon the existing medical scientist training program for M.D./Ph.D. students to establish a physician training program for residents to retain M.D. investigators in academic and biomedical research careers. That, she suggested, is a pool that is dwindling nationally.

Ongoing research

Hedayati, who is transferring most of her grants to Stony Brook, plans to continue conducting her own research.

She has been studying the link between chronic kidney disease, which affects about one in seven people, and other conditions, such as premature cardiovascular disease, susceptibility to depression and the role of inflammation.

“This is an area that’s prevalent, but understudied,” said Igarashi. 

She is searching for nontraditional biomarkers associated with kidney function decline, especially in patients with heart failure.

Patients with heart failure are at increased risk of acute and chronic kidney failure.

Igarashi is confident that Stony Brook’s new vice dean for research will serve patients on Long Island and beyond.

“She would not have taken this job unless we assured her that she would be able to continue to see patients in the clinic as well as in the hospital,” said Igarashi. “That is a core value for her.”

Echoing those sentiments, Hedayati suggested she has a “patient-centered approach in everything I do.”

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136 students comprise the RSOM Class of 2027, shown here reciting the Hippocratic Oath.
New RSOM student Jasmine Stansil (center), with her parents and grandparents at the school’s White Coat Ceremony.
Dean Peter Igarashi, MD
Adam Bruzzese wearing his first white coat after receiving from Andrew Wackett, MD, Vice Dean of Undergraduate Medical Education.

136 students launch journey into Medicine at traditional White Coat Ceremony

At the Renaissance School of Medicine’s (RSOM) White Coat Ceremony, 136 incoming students donned their physician “white coats” and took the Hippocratic Oath for the first time. Held at Stony Brook University’s Staller Center, the annual ceremony brings students, their families, and faculty together as the academic year begins and members of the Class of 2027 embark on their journeys toward becoming physicians. The RSOM has held the White Coat Ceremony since 1998.

The incoming students are a select group, and according to RSOM administrators is one of the most diverse classes in the school’s history. Only 8.5 percent of all applicants to the RSOM for 2023-24 were accepted into the program. Approximately 20 percent of class consists individuals from historically marginalized communities, and 54 percent of the class are women.

Collectively the students received their undergraduate degrees from 66 different colleges and universities from around the country. Stony Brook University (20) and Cornell University (17) were the undergraduate schools with the most representation. The class has a combined median undergraduate GPA of 3.89. While many of the new students are from different areas of the country, 77 percent hail from New York State.

“To the Class of 2027, you are entering medicine at an exhilarating time,” said Peter Igarashi, MD, Dean of the RSOM, who presided over his first White Coat Ceremony. “Scientific discoveries in medicine are occurring at a breathtaking and awe-inspiring rate. Diseases that were rapidly fatal when I was a medical student, such as multiple myeloma and leukemia, are now routinely treated. Advances in human genetics have enabled truly personalized medicine, and the development of an effective Covid-19 vaccine less than one year after the onset of the pandemic saved almost 20 million lives and underscored the essential role that science plays in public health.”

All of the students have a story as to how and why they have chosen Medicine as a profession.

For New York City native Adam Bruzzese, an NYU graduate, his family’s difficulties and challenges they had within the healthcare system was a big trigger to increasing his passion for medicine. Adam’s 11-year-old sister had mysteriously become paralyzed, and he played an integral part in providing her healthcare as a teenager and college student. He witnessed disparities of care as she moved through the health system, plus the myriad  of tests and physician opinions along the way. It was eventually determined her paralysis was caused by Lyme Disease.

Manteca, California native Jasmine Stansil, a standout student in high school and at the University of California, San Diego, was always fascinated by the human body as a kid. She also became captivated by how physicians can have an incredible impact on human life when she watched Untold Stories of the ER. But she was most inspired to pursue Medicine because of her grandmother, who endured multiple strokes.

“Watching doctors provide her care made me want to do the same for others,” says Stansil. “I am hoping to become an academic physician who will provide clinical care, teach and conduct research.”

Jerome Belford, one of the 20 class members who attended Stony Brook University as an undergraduate, described his interest in medicine as coming from a “passion that stems from a desire to promote physical and emotional health and wellness.”

From Long Island, Belford is a volunteer EMT who decided to attend the RSOM because of its broad research and clinical opportunities and standout education that provides experiential and hands-on medical training. He hopes to eventually provide patients who have historically not had access to the best medical resources improved care, either as an emergency physician or though primary care as an internist.

White coat ceremonies are an initiation rite and are symbolic to Medicine as a profession that combines professionalism with scientific excellence and compassionate care. In an era of telemedicine, aging populations, new knowledge about infections and diseases, and emerging technologies, Medicine remains a dynamic and changing profession that continues to impact the health and well-being of society.

All photos by Arthur Fredericks

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Chetan Potu poses to show his match to Stanford Health Care in California for a residency in Physical Medicine and Rehabilitation. Photo by Arthur Fredericks
A scene of jubilance with this group of Renaissance School of Medicine matching students – in total 121 graduating students matched to residency programs in New York State and around the nation. Photo by Arthur Fredericks
A scene of jubilance with this group of Renaissance School of Medicine matching students – in total 121 graduating students matched to residency programs in New York State and around the nation. Photo by Arthur Fredericks
Ashley Ferguson, center, with her family at Match Day, holds a sign showing her residency match to General Surgery at the University of Rochester/Strong Memorial. Photo by Arthur Fredericks

As the U.S. faces challenges with health care delivery systems and shortages of physicians will likely continue in the future, the Renaissance School of Medicine at Stony Brook University continues to produce new crops of physicians for the workforce each year. This year at its annual Match Day, 121 graduating students matched to residency programs around the country, from New York State to 19 other states and Washington, DC. More than one-quarter of these students (26%) matched to residency programs at Stony Brook Medicine.

Match Days are held nationwide each year, a celebratory event when students learn of their residency training assignments. Administered by the National Resident Matching Program, this year more than 40,000 positions were filled — a record for the NRMP’s 70-year history.

“Congratulations to all of you, and remember that things are going to work out regardless of where you have matched to,” said Dr. Peter Igarashi, dean of the RSOM, who waved his own residency notice letter that he received years ago from his Match Day, one which revealed a choice that he did not expect and was not his first choice. “You have accomplished this at a time when a worldwide pandemic was at the center of your medical school training, an impressive feat.”

A majority of the matching students will stay in New York State for their residency training — 59%. Of that portion, 55% will be employed on Long Island, and 45% at Stony Brook Medicine.

The top residency training programs matched to included Anesthesiology (21), Internal Medicine (16), Psychiatry (12), and Emergency Medicine (11). A solid portion of the students (21%) matched to primary care specialties, such as Medicine and Pediatrics. This is an important portion entering primary care fields, as the country faces primary care shortages ranging from 21,000 to 55,000 practitioners over the next decade, according to an Association of American Medical Colleges 2021 report.

In addition to students matching at Stony Brook and other hospitals across New York State such as Montefiore Medical Center, Memorial Sloan Kettering and University of Rochester, they also matched to residencies at nationally recognized institutions such as Tufts Medical Center in Massachusetts, the Mayo Clinic in Minnesota, and Johns Hopkins Hospital in Maryland.

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