CLOSE
Stony Brook University

by -
0 664
Iwao Ojima and Martin Kaczocha (foreground) led the Stony Brook team in developing its class of Fatty Acid Binding Proteins (FABPs) a promising set of drug targets for new therapies. Photo by John Griffin, Stony Brook University

The “FABP” inhibitor is part of a series of compounds that uses the body’s natural marijuana-like substances to curb pain and inflammation

 Six years ago Stony Brook University through the Research Foundation for the State University of New York licensed a promising technology to Artelo Biosciences that identified Fatty Acid Binding Proteins (FABPs) as drug targets of the body’s endocannabinoid system for a potentially promising way to treat pain, inflammation and cancer. Now the first one of these compounds has been cleared by the Food and Drug Administration (FDA) for human clinical trials.

Artelo announced this week that the FDA’s initial approval of one of the FABP5 (5 indicates a specific protein) selective compounds called ART26.12 enables the company to initiate its first human phase 1 single ascending dose study of the drug. The company states that ART26.12 will address a critical need for cancer patients, treating chemotherapy-induced peripheral neuropathy. Phase 1 clinical trials are expected to be launched internationally during the first half of 2025.

ART26.12 is the lead compound in the series of FABP5 inhibitors under development. In 2018, Artelo received an exclusive license to the intellectual property of all FABP inhibitors for the modulation of the endocannabinoid system.

The work on FABPs originated with Iwao Ojima, PhD, SUNY Distinguished Professor in the Department of Chemistry at Stony Brook University, Martin Kaczocha, PhD, Associate Professor in the Department of Anesthesiology in the Renaissance School of Medicine at Stony Brook University, and Dale Deutsch, PhD, Professor Emeritus in the Department of Biochemistry and Cell Biology at Stony Brook University, a research collaboration affiliated with  the Institute of Chemical Biology and Drug Discovery (ICB & DD). They identified the action of FABPs as drug targets. Specifically, FABP5 was identified as the intracellular transporter for the endocannabinoid anandamide (AEA), a neurotransmitter produced in the brain that binds to cannabinoid receptors.

The research group demonstrated in the laboratory that elevated levels of endocannabinoids can result in beneficial pharmacological effects on stress, pain and inflammation and also ameliorate the effects of drug withdrawal. Drs. Ojima (also Director of the ICB & DD), Kaczocha, Deutsch and colleagues discovered that by inhibiting FABP transporters, the level of AEA is raised. The finding provided the basis for the drug development approach to elevate the levels of AEA.

Artelo took this concept and approach to further develop the compounds. Their scientists collaborated with the Stony Brook team to reach new findings that has led to the commercialization and use of the first drug (ART26.12) in a potential pipeline of drugs to treat pain and inflammation.

After the license to Artelo was finalized, Drs. Ojima and Kaczocha under a contract with Artelo synthesized and evaluated compound candidates with high FABP5 potency and selectivity, an effort that culminated in the development of the lead candidate, SB-FI-1621, which Artelo named ART26.12.

“This is the first clinical stage compound targeting the FABP pathway, an important and exciting milestone,” says Sean Boykevisch, PhD, Director of Intellectual Property Partners in Stony Brook’s Technology Transfer Office. “The fundamental and translational research conducted by the Stony Brook team and their subsequent collaboration with Artelo resulted in a true bench-to-bedside program with the goal of better patient experiences and outcomes.”

“We look forward to sharing the initial clinical results with ART26.12 next year,” says Gregory D. Gorgas, President and CEO of Artelo Biosciences. “As the leading company pursuing FABP inhibition we are committed to building on the unique, lipid-modulating mechanism of our FABP inhibitor platform to address life-altering pathologies for which there are few, if any, safe and effective pharmaceutical treatments.”

For more about the Stony Brook research that developed FABP inhibitors and the grant to support years of research, see this news.

For more details on the FDA clearance news of the drug, and Artelo’s R&D plan, see this news.

 

 

by -
0 760
Simon Birrer Photo by Andrea Hoffmann

By Daniel Dunaief

When he was young, Simon Birrer asked his parents for a telescope because he wanted to look at objects on mountains and hills.

Simon Birrer.  Photo Studio, Mall of Switzerland

While he was passionate about science and good at math, Birrer didn’t know at the time he’d set his sights much further away than nearby hills or mountains in his professional career.

An Assistant Professor in the department of Astronomy and Physics at Stony Brook University, Birrer uses telescopes that generate data from much further away than nearby hills as he studies the way light from distant galaxies bends through a process called gravitational lensing. He also works to refine a measure of the expansion of the universe.

“All matter (including stars in galaxies) are causing the bending of light,” Birrer explained in an email. “From our images, we can infer that a significant fraction of the lensing has to come from dark (or more accurately: transparent) matter.”

Dark matter describes how a substance of matter that does not interact with any known matter component through a collision or pressure or absorption of light is transparent.

While they can’t see this matter through various types of telescopes, cosmologists like Birrer know it’s there because when it gets massive enough, it creates what Albert Einstein predicted in his theory of relativity, altering spacetime. Dark matter is effectively interacting with visible matter only gravitationally.

Every massive object causes a gravitational effect, Birrer suggested.

When a single concentration of matter occurs, the light of a distant galaxy can produce numerous images of the same object.

Scientists take several approaches to delens the data. They rely on computers to perform ray-tracing simulations to compare predictions with the astronomical images.

The degree of lensing is proportional to the mass of total matter.

Birrer uses statistics and helps draw conclusions about the fundamental nature of the dark matter that alters the trajectory of light as it travels towards Earth.

He conducts simulations and compares a range of data collected from NASA Hubble and the James Webb Space Telescope.

Hubble constant

Beyond gravitational lensing, Birrer also studies and refines the Hubble constant, which describes the expansion rate of the universe. This constant that was first measured by Edwin Hubble in 1929.

“An accurate and precise measurement of the Hubble constant will provide us empirical guidance to questions and answers about the fundamental composition and nature of the universe,” Birrer explained.

During his postdoctoral research at UCLA, Birrer helped develop a new “formalism to measure the expansion history of the universe accounting for all the uncertainty,” Tomasso Treu, a Vice Chair for Astronomy at UCLA and Birrer’s postdoctoral advisor. “These methodological breakthroughs lay the foundation for the work that is being done today to find out what is dark matter and what is dark energy,” which is a force that causes the universe to expand at an accelerating rate.

Treu, who described Birrer as “truly outstanding” and one of the ‘best postdocs I have ever interacted with” in his 25-year career, suggested that his former student was relentless even after impressive work.

Soon after completing a measurement of the constant to two percent precision, Birrer started thinking of a “way to redo the experiment using much weaker theoretical assumptions,” Treu wrote in an email. “This was a very brave thing to do, as the dust had not settled yet on the first measurement and he questioned everything.”

The new approach required considerable effort, patience and dedication.

Birrer was “motivated uniquely by his intellectual honesty and rigor,” Treu added. “He wanted to know the answer and he wanted to know if it was robust to this new approach.”

Indeed, researchers are still executing this new measurement, which means that Treu and others don’t know how the next chapter in this search. This approach will, however, lead to greater confidence in whatever figure they find.

Larger collaborations

Simon Birrer. Photo by Rebecca Ross

Birrer is a part of numerous collaborations that involve scientists from Europe, Asia, and Middle and South America.

He contributes to the Legacy Survey of Space and Time (LSST). A planned 10-year survey of the southern sky, the Vera C. Rubin Observatory is under construction in northern Chile.

The Simonyi Survey Telescope (SST) at the observatory will survey half the sky every three nights. It will provide a movie of that part of the sky for a decade.

The telescope and camera are expected to produce over 5.2 million exposures in a decade. In fewer than two months, a smaller commissioning camera will start collecting the first light. The main camera will start collecting images within a year, while researchers anticipate gathering scientific data in late next year or early in 2026.

The LSST is expected to find more strong gravitational lensing events, and in particular strongly lensed supernovae, than any prior survey.

Birrer is the co-chair of the LSST Strong Lensing Science Collaboration and serves on the Collaboration Council of the LSST Dark Energy Science Collaboration.

Birrer is also a part of the Dark Energy Survey, which was a predecessor to LSST. Researchers completed data taking a few years ago and are analyzing that information.

From mountains to the island

Born and raised in Lucerne, Switzerland, Birrer, who speaks German and the Swiss dialect, French and English, found physics and sociology appealing when he was younger.

“I was interested in how the world works,” he said.

While attending college at ETH Zurich in Switzerland, he became eager to address the numerous unknown questions in cosmology and astrology.

“How little we know about” these fields “dragged me in that direction,” said Birrer.

An avid skier, mountaineer and soccer player, Birrer bikes the five miles back and forth to work from Port Jefferson.

In addition to adding a talented scientist, Stony Brook also brought on board an effective educator.

Birrer is “knowledgeable and caring, patient and at the same time, he knows how to challenge people to achieve their best,” Treu explained. “I am sure he will be a wonderful addition to the faculty and he will play a leading role in training the next generation of scientists.”

In terms of the advice he found particularly helpful in his career, Birrer suggested he needed a nudge to combine his passion for theory with the growing trove of available data. His PhD advisor told him to “touch the data,” he said. The data keeps him humble and provides a reality check.

The friction between thought and data “leads to progress,” Birrer added. “You never know whether the thoughts are ahead of the experiments (data) or whether the experiments are ahead of the thoughts.”

by -
0 883
From left, Elisa DiStefano, NewsdayTV; Jennifer Nicholson, COO, RMHC NYM; Leah Laurenti; Anthony Nunziata; Joy Mangano; Mario Mattera, NY State Senator; Nick Croce, RMHC NYM. Photo from Ronald McDonald House Charities NY Metro

Concert at the Engeman Theater raises $45k for Ronald McDonald House Charities NY Metro

More than 200 guests turned out to a spectacular gala benefit concert put on by the  Ronald McDonald House Charities NY Metro on Tuesday, June 18th, at the John W. Engeman Theater in Northport, NY, to help support the Capital Campaign to build a new Ronald McDonald House at Stony Brook Children’s Hospital. The event raised $45,000 for the effort.

Romantic singing sensation Anthony Nunziata headlined the evening with a mesmerizing mix of covers and original songs. Long Island’s own Leah Laurenti opened the show with a heartfelt rendition of Keane’s “Somewhere Only We Know,” setting the tone for a night of touching performances and community spirit.

Inventor and entrepreneur Joy Mangano served as the emcee, highlighting the critical need for a Ronald McDonald House at Stony Brook Medical Center by introducing the Griswold family, who utilized the Ronald McDonald Stony Brook Family Rooms in 2017. The Griswolds stayed bedside as their 3-month-old son Nash underwent multiple life-saving procedures. Today, Nash is a thriving, active seven-year-old. Their story underscored the importance of having a nearby sanctuary during medical crises, a need the new Ronald McDonald House aims to fulfill.

Nick Croce, Co-Chair of the Stony Brook Advisory Council and RMHC New York Metro Board Member, organized the event and welcomed attendees. Reflecting on the evening, Croce expressed, “I want to thank our event sponsors and guests for showing up in support of our efforts to build a home-away-from-home for families with sick children here on Long Island. Our goal is to relieve as much stress as possible so families can be there for their sick children.”

Construction for the new Ronald McDonald House in Stony Brook is set to begin this year, with an expected opening in 2026. The new facility will feature 30 private bedrooms, plus a fitness center, communal kitchens, a movie theater, a playroom, and much more. It will provide essential support to families, ensuring they can stay close to their hospitalized children without the added burden of finding and funding nearby accommodations.

To learn more or to get involved in the Capital Campaign to build the Ronald McDonald House at Stony Brook Children’s Hospital, visit https://www.rmhcnym.org.

About Ronald McDonald House Charities NY Metro

Ronald McDonald House Charities New York Metro (RMHC NYM) provides free lodging, meals, and emotional support to keep families seeking medical treatment for their sick children near the care they need and the families they love.

by -
0 348
Dr. Alexander Orlov. Photo by John Griffin/SBU

Alexander Orlov recognized for contributions to the AIChE’s division dedicated to promoting research, education and innovation related to the design of creative engineering solutions to environmental challenges

Alexander Orlov, PhD, Professor in the Department of Materials Science and Chemical Engineering in the College of Engineering and Applied Sciences at Stony Brook University, is the recipient of the American Institute of Chemical Engineers’ (AIChE) Dr. Peter. B. Lederman Environmental Division Service Award.

The award recognizes outstanding service to the Environmental Division the AIChE. The AIChE has more than 60,000 members from more than 110 countries and is the world’s leading organization for chemical engineering professionals.

Orlov will receive the award during the AIChE’s annual meeting, which takes October 27 to 31 at the Convention Center in San Diego.

As an integral member of the AIChE, Orlov initiated fundraising and outreach efforts for the Environmental Division that helped to double its annual budget. His leadership led to a substantial increase in the Division’s membership. Both efforts led to his nomination for the service award.

Orlov is currently Co-Chair of the AIChE’s Sustainable Engineering Forum (SEF) Education Committee and an Institute for Sustainability Board Member. Previously, the Institute recognized Orlov for his education and commercialization efforts with the 2017 SEF Education Award and the 2021 AIChE SEF Industrial Practice Award.

In addition to his departmental faculty position at Stony Brook, Orlov is a faculty member of the Consortium for Interdisciplinary Environmental Research, and an affiliate faculty member of the Chemistry Department and the Institute for Advanced Computational Science. He also serves as a Co-Director of the Center for Laser Assisted Advanced Manufacturing and Center for Development and Validation of Scalable Methods for Sustainable Plastic Synthesis and Processing.

Orlov received his PhD in Chemistry from the University of Cambridge. He has been teaching and conducting research at Stony Brook University since 2008.

 

by -
0 940
Richard McCormick. Photo courtesy Stony Brook University

By Daniel Dunaief

The State University of New York Board of Trustees has named former Rutgers President Richard McCormick, 76, interim president of Stony Brook University as the school continues its search for a seventh president.

McCormick, who will take over the reigns at the downstate flagship SUNY school on August 1st, replaces Maurie McInnis, who left Stony Brook after four years to become the president of Yale University on July 1.

Dr. Bill Wertheim, Executive Vice President for Stony Brook Medicine, has been serving as Officer-in-Charge and Stony Brook University Hospital’s Governing Body since July 1.

McCormick, who was president of Rutgers from 2002 to 2012 and has taught and studied United States political history in the 19th and 20th centuries, has over four decades of experience in higher education, including leading several highly ranked public universities.

McCormick will oversee Stony Brook University and Stony Brook Medicine and will serve as part of the management team of Brookhaven National Laboratory.

“Each step we take in this leadership transition is important, and we welcome Dr. McCormick,” John King, Jr, SUNY Chancellor said in a statement. “His vast higher education experience will continue to move this esteemed university forward as the campus conducts a national search for its new president.”

McCormick welcomed the chance to lead Stony Brook during this transition period.

Stony Brook “has achieved national stature yet remains fully engaged with its Long Island community, for which it is an economic engine,” McCormick said in a statement. “My thanks to the SUNY Board of Trustees, Chancellor King and the Stony Brook Council for this opportunity.”

As an interim president, McCormick will not be a candidate to become the next permanent president.

In addition to his tenure at Rutgers, which started in 1976 when he joined the history department, McCormick also was vice chancellor and provost at the University of North Carolina at Chapel Hill from 1992 to 1995 and was president of the University of Washington from 1995 to 2002.

The incoming interim Stony Brook president earned his Bachelor of Arts degree from Amherst College in American Studies and his PhD in history from Yale in 1976, 20 years before McInnis also earned her PhD in the History of Art from the New Haven-based Ivy league school she now leads.

McCormick started his academic career at Rutgers, where he was a member of the history faculty from 1976 to 1992. He was also Dean of the Faculty of Arts and Sciences.

McCormick is the son of Richard Patrick McCormick, a former Rutgers professor and Katheryne Levis, a former Rutgers administrator.

McCormick and his father co-taught an American history course.

An author of several books, McCormick is writing a book on the history of American political corruption from the 17th century to the present.

Rutgers achievements

McCormick, who earned his high school diploma from Piscataway Township High School in Piscataway, New Jersey, orchestrated constructive changes in his hometown university during his presidency.

McCormick helped raise $650 million while he was president.

Four years after becoming president, the university reorganized the undergraduate colleges on the New Brunswick campus into a School of Arts and Sciences and School of Environmental and Biological Sciences.

The reorganization included a comprehensive new curriculum at the School of Arts and Sciences, first year seminars, signature courses, expansion opportunities for undergraduate research and honors programs and support for top undergraduates competing for highly competitive scholarships and awards.

In the final years of his tenure, he merged Rutgers with the Robert Wood Johnson Medical School and divisions of the University of Medicine and Dentistry of New Jersey. The New Jersey Legislature passed a bill to integrate almost all units of the University of Medicine and Dentistry of New Jersey into Rutgers.

“Dr. McCormick’s notable accomplishments as president of Rutgers from 2002 until 2012 included reinvigorating undergraduate education, elevating its standing in the top tier of public research universities, realizing a longstanding goal of returning medical education to the university’s portfolio, and improving and strengthening connections with important partners, including alumni and local communities,” Wertheim said in a statement. “He is the ideal leader to help Stony Brook sustain its momentum as New York’s flagship university.”

The former Rutgers president led the school when it installed 40,000 high-efficiency solar panels over two large surface parking lots on the Livingston campus, producing over eight megawatts of power, which, at the time, was the largest renewable energy system built on a college campus in the country. Rutgers has continued to add solar panels.

Stony Brook momentum

McCormick’s experience with solar energy dovetails with some of Stony Brook’s recent environmental initiatives and successes.

With the support of the Simons Foundation and Bloomberg Philanthropies, Stony Brook University won the competitive process as the lead institution to create a climate solutions center on Governors Island. The New York Climate Exchange will develop and deploy dynamic solutions to the global climate crisis, will provide educational and research opportunities and will serve as a place for New Yorkers to benefit from the green economy.

The Climate Solutions Center will include 400,000 square feet of green-designed building space, including research labs, classroom space, exhibits, greenhouses, mitigation technologies and housing facilities.

McCormick takes over as interim president at a time when Stony Brook has achieved some important financial and academic victories.

A year ago, the Simons Foundation made a $500 million endowment gift to Stony Brook. The gift, which will be spread out over seven years, was the largest unrestricted donation to an institution of higher education in United States history.

The Foundation gift, which the state will match on a 1:2 program, and other philanthropic contributions are expected to increase the endowment by as much as $1 billion.

Stony Brook recently climbed 19 spots in the rankings of colleges from US News and World Report, ranking 58th in the rankings. That’s the highest ever rank for a State University of New York institution. The school also placed 12th among national universities for social mobility rank.

“Stony Brook is a world-class institution, moving on an upward trajectory, educating the next generation of leaders and thinkers and bettering our society through research and economic development,” Stony Brook Council Kevin Law said in a statement. “I am pleased to welcome Dr. McCormick, whose accomplishments and vision in higher-education leadership are nothing short of extraordinary, as our interim president, and to begin the search for our next permanent president.”

Challenges ahead

McCormick will likely face the same some of the same challenges other university presidents, interim or not, have dealt with as protestors have expressed their frustrations over the ongoing conflict between Israel and Hamas in Gaza.

At numerous universities, protests disrupted exams, classes and graduation ceremonies.

College presidents have tried to balance between the rights of students to assemble and express themselves and the university’s need to protect various groups of students from intimidation, bullying, or threats.

Local politicians welcomed McCormick. “I look forward to getting to know Dr. McCormick and collaborating with him to ensure that Stony Brook remains a premier institution of higher learning, providing a safe environment for students of all religions,” said Rep. Nick LaLota (R-NY1).

by -
0 473
Pictured from left are Town Clerk Kevin LaValle; Councilman Neil Manzella; Councilwoman Jane Bonner; Aman Mistry; Siddhant Desai; Supervisor Dan Panico; Councilmember Jonathan Kornreich; Councilman Neil Foley; Councilman Michael Loguercio and Councilwoman Karen Dunne Kesnig.

At the June 6 Brookhaven Town Board Meeting, Councilmember Jonathan Kornreich presented two Stony Brook University students, Aman Mistry and Siddhant Desai with a proclamation recognizing Scholars for Medicine Society.

The organization provides an environment to nurture leadership and problem-solving abilities of the Stony Brook community’s future physicians. They do it by hosting Stony Brook University Healthcare Innovation Challenge and encouraging student innovation in a multidisciplinary, collaborative environment supported by faculty mentorship. They also promote student-run community health initiatives that translate problem-solving skills to real-world impact in the greater community.

In addition, they recruit a diverse array of sponsors and event support, including Stony Brook University, The Contribution Project, the Protect Our Planet (POP) Movement, Duck Donuts in Selden, Councilmember Jonathan Kornreich, and David L. Calone. The Scholars for Medicine Society at Stony Brook University has facilitated connection in the Stony Brook community through campus-wide events like the Healthcare Innovation Challenge. 

For more information about the Scholars for Medicine Society at Stony Brook University, visit the Stony Brook University website at www.stonybrook.edu.

by -
0 827
Stony Brook University Hospital

Stony Brook University Hospital (SBUH) has been recognized as a 2024-25 Best Hospital by U.S. News & World Report, ranking in the top 15 in the state. SBUH climbed to a No. 12 ranking overall in New York State out of more than 153 hospitals statewide, up from No. 13 in the state last year. In addition to ranking in the top 8% overall in New York State, SBUH also rated high performing in 5 adult specialties nationwide, including Geriatrics, Neurology & Neurosurgery, Orthopedics, Urology and Pulmonology & Lung Surgery. The announcement was made in a press release on July 16.

“We are immensely proud to be recognized by U.S. News for our commitment to excellence in patient care,” said William A. Wertheim, MD, MBA, Officer in Charge, Stony Brook University and Executive Vice President, Stony Brook Medicine. “This recognition is a testament to the dedication, skill, and compassion of our entire Stony Brook Medicine team and reflects our unwavering focus on providing patients the highest quality of care.”

“This honor highlights Stony Brook University Hospital’s continued efforts to deliver the highest quality care to our patients,” said Carol Gomes, MS, FACHE, CPHQ, Chief Executive Officer at Stony Brook University Hospital. “I am grateful to our entire team for their tireless efforts ensuring that our patients receive the comprehensive treatment and support they deserve.”

The evaluation of SBUH includes data from Stony Brook Southampton Hospital, Stony Brook Children’s Hospital and Stony Brook Eastern Long Island Hospital, which make up the Stony Brook Medicine healthcare system.

U.S. News evaluated nearly 5,000 hospitals across 15 specialties and 20 procedures and conditions; only 11% of evaluated hospitals earned a Best Hospitals ranking. Hospitals awarded a “Best” designation excelled at factors such as clinical outcomes, level of nursing care and patient experience.

“For 35 years, U.S. News has been a leading resource for patients navigating their health care decisions,” said Ben Harder, chief of health analysis and managing editor at U.S. News. “A ‘Best Hospital’ recognition empowers patients to seek out medical care from the best of the best to treat their illness or condition.”

To calculate the Best Hospitals rankings, U.S. News evaluated each hospital’s performance on objective measures such as risk-adjusted mortality rates, preventable complications and level of nursing care. The Best Hospitals Specialty rankings methodology and Procedures & Conditions ratings methodologymeasure patient outcomes using data from millions of records provided by the Centers for Medicare & Medicaid Services. This year, among other methodology refinements, U.S. News incorporated new data on care provided to patients with Medicare Advantage insurance and on care provided to outpatients, nearly doubling the number of patients included in its annual data analysis. The Procedures & Conditions ratings are based entirely on objective quality measures.

For more information, visit Best Hospitals.

by -
0 743
1 of 2
Dr. Allison McLarty
Dr. Henry Tannous

Two Stony Brook Heart Institute (SBHI) cardiothoracic surgeons have been inducted into the American Association for Thoracic Surgery (AATS). Member inductions are reserved for a limited number of select physicians each year and SBHI has the distinction of having two cardiothoracic surgeons as AATS members. Henry Tannous, MD, Chief, Cardiothoracic Surgery and Co-Director, SBHI, was inducted during AATS’s 104th annual meeting on April 29th and Allison McLarty, MD, Director, Extracorporeal Membrane Oxygenation (ECMO) Program and Co-Director, Ventricular Assist Device (VAD) Program, was selected by the AATS for induction in 2020. The membership recognizes expertise, innovation and outstanding reputation for clinical excellence in both adult cardiac and thoracic surgery.

“It is an honor to have been inducted into the American Association for Thoracic Surgery and to be acknowledged among so many esteemed researchers, clinicians and clinical leaders,” says Dr. Tannous. “I am immeasurably grateful to join this noteworthy group of individuals, including my accomplished colleague Dr. McLarty. Our entire cardiothoracic team is focused on one goal — to deliver the best in surgical outcomes to our patients.”

From Dr. McLarty, Stony Brook’s first AATS inductee: “Being a part of the elite AATS community is humbling and inspires me daily to be even more resolute and unwavering in my pursuit of cardiothoracic excellence. It is a pleasure to extend my congratulations to Dr. Tannous.”

Stony Brook’s Chair of the Department of Surgery, Apostolos Tassiopoulos, MD, shared his congratulations, “Drs. Tannous and McLarty have truly set a benchmark in their striving for quality cardiothoracic care — their hard work and dedication are always evident, and this honor is well deserved. Placing Stony Brook among the most advanced facilities in the U.S., our skilled and dedicated heart and lung surgeons and our growing cardiothoracic program continues to raise the bar for cardiac and thoracic care here on Long Island.”

Founded in 1917, the prestigious AATS is composed of more than 1,500 of the world’s foremost cardiothoracic surgeons from 46 countries and recognizes the height of professional achievement and significant contributions of those at the top of their field.

For more information about Dr. Tannous and Dr. McLarty, visit https://heart.stonybrookmedicine.edu/AATS

 

by -
0 710
Rachel Redhead. Photo by John Griffin/SBU

Stony Brook University Director of People & Culture, Rachael Redhead, has been awarded the State University of New York  (SUNY) Chancellor’s Award for Excellence in Professional Service.

Working in a shared services model, which includes Finance & Administration (F&A), the Executive Office, as well as Marketing & Communications, Rachael’s responsibilities include oversight of human resource services for over 1,200 staff members across several diverse University areas including Budget, Financial Planning & Analysis; Enterprise Risk Management; Facilities & Services; Finance; HR; Marketing & Communications, Government & Community Relations, Athletics, and the Executive Office. During her tenure at Stony Brook, Rachael has implemented successful models for HR functions such as employee engagement, retention and training as well as provided organizational development and support from Central HR to various Divisions and Departments. She is also a leader of the F&A Alliance for Culture, Diversity & Inclusion at Stony Brook University.

The Chancellor’s Awards for Excellence are System-level honors conferred to acknowledge and provide recognition for consistently superior professional achievement and to encourage the ongoing pursuit of excellence. Individuals nominated for these awards must meet all prescribed eligibility criteria and must be individuals of achievement, committed to the State University and its students, respected by the campus community and worthy of emulation by colleagues and students on the home campus and across SUNY.

“I congratulate Rachael on this well-deserved achievement,” said Jed Shivers, Senior Vice President, F&A. “She is an integral member of our F&A team, serving each of our VP areas and their unique goals, nuances and functions. Rachael consistently remains committed to treating each request, from each area, with her total focus, utmost attention and an enthusiastic attitude. She is always willing to help, and is someone who treats all members of our faculty, staff and student populations with respect, diplomacy and dignity.”

Rachael joined Stony Brook University in 2014 as an HR Coordinator in Finance & Administration. After working in F&A for three years, Rachael was recognized for her achievements and appointed to Senior Human Resources Business Partner of DoIT in 2017. In this position, she continued to assume additional responsibilities, routinely going above and beyond the scope of her role and was appointed in 2021 to her current position.

by -
0 1576
Daniel Marx in front of one of the magnets at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory. Photo courtesy of BNL

By Daniel Dunaief

In a world filled with disagreements over everything from presidential politics to parking places, numbers — and particularly constants — can offer immutable comfort, as people across borders and political parties can find the kind of common ground that make discoveries and innovations possible.

Many of these numbers aren’t simple, as anyone who has taken a geometry class would know. Pi, for example, which describes the ratio of the circumference of a circle to its diameter, isn’t just 3 or 3.14.

In classes around the world, people challenge their memory of numbers and sequences by reciting as many digits of this irrational number as possible. An irrational number can’t be expressed as a fraction.

These irrational numbers can and do inform the world well outside of textbooks and math tests, making it possible for, say, electromagnetic radiation to share information across a parallel world or, in earlier parlance, the ether.

“All electronic communication is made up of waves, sines and cosines, that are defined and evaluated using pi,” said Alan Tucker, Toll Distinguished Teaching Professor in the Department of Applied Mathematics and Statistics at Stony Brook University. The circuits that send and receive information are “based on calculations using pi.”

Scientists can receive signals from the Voyager spacecraft, launched in 1977 and now over seven billion miles away, thanks to the ability to tune a circuit using math that relies on pi and numerous mathematical formulas where the sensitivity to the signal is infinite.

The signal from the spacecraft, which is over 16 years older than the average-aged person on the planet, takes about 10 hours to travel back and forth.

“Think of 1/x, where x goes to 0,” explained Tucker. “Scientists have taken that infinity to be an infinite multiplier of weak signals that can be understood.”

Closer to Earth, the internet, radio waves and TV, among myriad other electronic devices, all use generated and decoded calculations using pi.

“All space has an unseen mathematical existence that nobody can see,” said Tucker. “These are heavily based on calculations involving pi.”

Properties of nature

Constants reflect the realities of the world. They have “a property that is fundamental and absolute and that no one could change,” said Steve Skiena, Distinguished Teaching Professor of Computer Science at Stony Brook University. “The reason people discovered these constants as being important is because they are relating things that arise in the world.”

While pi may be among the best known and most oft-discussed constant, it’s not alone in measuring and understanding the world and in helping scientists anticipate, calculate and understand their experiments.

Chemists, for example, design reactions using a standard unit of measure called the mole, which is also called Avogadro’s number for the Italian physicist Amedeo Avogadro.

The mole provides a way to balance equations, enabling chemists to determine exactly how much of each reactant to combine to get a specific amount of product.

This huge number, which is often expressed as 6.022 times 10 to the 23rd power, represents the number of atoms in 12 grams of carbon 12. The units can be electrons, ions, atoms or molecules.

“Without Avogadro’s number, it would be impossible to determine the ratio of particular reactants,” said Elliot Smith, a postdoctoral researcher at Cold Spring Harbor Laboratory who works in John Moses’s lab. “You could take an educated guess, but you wouldn’t get good results.”

Smith often uses millimoles, or 1/1000th of a mole, in the chemical reactions he does.

“If we know the millimoles of each reactant, we can calculate the expected yield,” said Smith. “Without that, you’re fumbling in the dark.”

Indeed, efficient chemical reactions make it possible to synthesize greater amounts of some of the pharmaceutical products that protect human health.

Moles, or millimoles, in a reaction also make it possible to question why a result deviated from expectations. 

Almost the speed of light

Physicists use numerous constants.

“In physics, it is inescapable that you will have to deal with some of the fundamental constants,” said Alan Calder, Professor of Physics and Astronomy at Stony Brook University.

When he models stellar explosions, he uses the speed of light and Newton’s gravitational constant, which relates the gravitational force between two objects to the product of their masses divided by the square of the distance between them.

The stars Calder studies are gas ball reactions that also involve constants.

Stars have thermonuclear reactions going on in them as they evolve. Calder uses reaction rates that depend on local conditions like temperature, but there are constants in these.

Calder’s favorite number is e, or Euler’s constant. This number, which is about 2.71828, is useful in calculating interest in a bank account as well as in understanding the width of successive layers in a snail shell among many other phenomena in nature.

Electron Ion Collider

The speed of light figures prominently in the development and calculations at Brookhaven National Laboratory as the lab prepares to build the unique Electron Ion Collider, which is expected to cost between $1.7 billion and $2.8 billion.

The EIC, which will take about 10 years to construct, will collide a beam of electrons with a beam of ions to answer basic questions about the atomic nucleus.

“It’s one of the most exciting projects in the world,” said Daniel Marx, an accelerator physicist in the Electron Ion Collider accelerator design group at BNL.

At the EIC, physicists expect to propel the electrons, which are 2,000 times lighter than protons, extremely close to the speed of light. In fact, they will travel at 99.999999 (yes, that’s six nines after the decimal point) of the speed of light, which, by the way, is 186,282 miles per second. That means that light can circle the globe 7.48 times per second.

The EIC will increase the energy of ions to 99.999% of the speed of light. With only three nines after the decimal, the protons will be traveling at a slower enough speed that the designers of the collider will make the proton ring about 4 inches shorter over 2.4 miles to ensure that the protons and electrons arrive at exactly the same time.

The EIC will attempt to answer questions about the mass and spin of the nucleus. They hope to understand what happens with dense systems of gluons. By accelerating nuclei or protons to higher energies, they will get more gluons and will look for evidence of gluon saturation.

“The speed of light is absolutely fundamental to everything we do,” said Marx because it is fundamental to relativity and the particles in the accelerator are relativistic.

As for constants, Marx suggested that its value might look like a row of random numbers, but if those numbers are a bit different, that could “revolutionize” an understanding of physics.

In addition to a detailed understanding of atomic nuclei, the EIC could also lead to new technologies.

When JJ Thomson discovered the electron, he toasted it by saying, “may it never be of use to anyone.” That, however, is far from the case, as the electron is at the heart of electronics.

As for pi, Marx, like many of his STEM colleagues, appreciates this constant.

“Once you look at the mathematical statement of pi, and how it relates in various ways to other quantities in math and physics, it deepens your appreciation of how beautiful the whole universe is,” Marx said.

Prev1...343536...133Next Page 35 of 133
TBR News Media is your local news and entertainment website.
We provide you with the latest breaking news and information for your community.
Contact us: [email protected]

Most Viewed

©