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Above, a battle scene shot at Benner’s Farm in East Setauket last summer.
Film showcased at SBU’s Staller Center for the Arts

By Talia Amorosano

The wait is over. On Sunday, June 24, an integral piece of U.S. and Long Island history will be revisited in the geographic location where much of it actually took place. At 7 p.m., the Stony Brook University’s Staller Center for the Arts, 100 Nicolls Road, Stony Brook, will host the first major public screening of “One Life to Give,” a film about the friendship and lives of young American heroes Benjamin Tallmadge and Nathan Hale, whose actions would lead to the creation of a Revolutionary spy ring based on the North Shore of Long Island.

Presented in the Main Theater, doors will open at 6:45 p.m. After a message from publisher Leah Dunaief, a short behind-the-scenes documentary will be shown followed by the main film screening. After a message from the creators, the evening will conclude with a Q&A with the cast and crew. Admission to the event is free, courtesy of TBR News Media. No reservations are necessary.

Cast and crew gather around a camera to view playback last summer.

The film’s co-producer and writer, Michael Tessler, describes the film as an exploration of historical events with a human focus. “After spending several years researching Benjamin Tallmadge and the other heroes featured in our film, I began to look at them not as detached names in a textbook, but more so as real people, with real stories that deserve to be told,” he said.

 Dave Morrissey, the actor who portrays Tallmadge in the film, describes his character as a “22-year-old kid,” who, despite his relative youth, is “focused” and “grounded,” propelled into action by the death of his brother at the hands of the British. “When something like that happens to you, you turn into a machine … into something else,” said Morrissey. “If you channel the energy and do what’s right, the possibilities are endless.”

By focusing a metaphorical macro lens on the multidimensional characters of Tallmadge and Hale, the film traverses consequential moments of American history: the Battle of Long Island, the anointing of America’s first spy and the events that would lead to the creation of the Culper Spy Ring, a group of men and women who risked their lives and status to gather British intelligence for the Revolutionary cause. 

Though Tessler notes that the film is, at its heart, a drama, he and the film’s director and co-producer Benji Dunaief stress the cast and crew’s commitment to accuracy in their interpretation of historical events. 

“The history comes second to the narrative in most [other film adaptations of historical events],” says Dunaief. “Our approach with this film was the exact opposite. We wanted to see where we could find narrative within [pre-existing] history.” 

“Many of the lines from the film were plucked directly from the diaries of the heroes themselves,” stated Tessler. “We worked closely with historians and Revolutionary War experts to achieve a level of accuracy usually unseen in such a local production.”

The fact that many scenes from the film were shot in the locations where the events of the real-life narrative took place helped give the visuals a sense of truthfulness and the actors a sense of purpose.

“The location took production to the next level. It’s really crazy how closely related the sets we used were to the actual history,” said Dunaief, who specifically recalls filming at a house that contained wood from Tallmadge’s actual home. “It helped to inspire people in the cast to get into character.” 

Morrissey recalls spending a particularly inspiring Fourth of July on Benner’s Farm in East Setauket. “We were filming the war scenes with all the reenactors … in the cabin that we built for the set … in the town where the battles and espionage had really happened. There were fireworks going on in the background while we sang shanty songs. It was amazing.”

The Continental Army shoots off a cannon at Benner’s Farm.

Though locational and historical accuracy played a large role in making filming a success, ultimately, Dunaief and Tessler credit the resonance of “One Life to Give” to an engaged and participatory community. “This was a community effort on all accounts,” says Dunaief, noting the roles that the Benners, Preservation Long Island, The Ward Melville Heritage Organization, the Three Village Historical Society and others played to bring “One Life to Give” to fruition. 

The fact that the screening will take place at the Staller Center, in the heart of the community that helped bring the film about, represents a full-circle moment for the cast and crew. “We’re calling it a screening but it is so much more,” said Dunaief. “It is a fantastic example of how the community has stood by this film, from beginning to end.”

“We’re beyond honored and humbled to use a screen that has seen some of the greatest independent films in history,” said Tessler. “Stony Brook University has been a wonderful partner and extremely accommodating as we work to bring our local history to life.” 

Tessler projects confidence that viewers will leave the screening with a similar sense of gratitude. “This story shows a part of our history that I think will make the audience very proud of the place they call home.”

The future of ‘One Life to Give’: 

Michael Tessler and Benji Dunaief plan to show the film at festivals around the country, to conduct a series of screenings on Long Island, and to partner with local historical societies that can use it as an educational tool. Additionally, a sequel to “One Life to Give,” titled “Traitor,” is already in the works. Filming will begin this summer.

All photos by Michael Pawluk Photography

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Overuse may lead to serious side effects

By David Dunaief, M.D.

Dr. David Dunaief

Reflux (GERD) disease, sometimes referred to as heartburn, though this is more of a symptom, is one of the most commonly treated diseases. Continuing with that theme, proton pump inhibitors (PPIs), which have become household names, are one of the top-10 drug classes prescribed or taken in the United States. In fact, Centers for Disease Control and Prevention data shows that use has grown precipitously in the 10 years ending in 2010 for those ages 55 to 64, from 9 percent of the population to 16 percent (1). This is a 78 percent increase in the number of prescriptions for these drugs.

In 2010, there were 147 million prescriptions filled for PPIs (2). The class of drugs includes Prevacid (lansoprazole), Prilosec (omeprazole), Nexium (esomeprazole), Protonix (pantoprazole) and Aciphex (rabeprazole). This growth may not capture the fact that several of these medications are now available over the counter.

I remember when PPIs were touted as having one of the cleanest side effect profiles. This may still be true, if we are using them correctly for reflux disease. They are supposed to be used for the short term. This can range from 7 to 14 days for over-the-counter PPIs to 4 to 8 weeks for prescription PPIs.

Why did we not know that this class of drugs might be associated with chronic kidney disease, dementia, bone fractures and Clostridium difficile (a bacterial infection of the gastrointestinal tract) before they were approved? Well, if you look at the manufacturers’ package inserts for these drugs, the trials, such as for Protonix, were no longer than a year (3), yet we are putting patients on these medications for decades. And the longer people are on them, the more complications arise.

Typical symptoms of reflux are heartburn and/or regurgitation. Atypical symptoms include coughing and throat clearing. But these atypical symptoms may not be as common as you might think. In fact, in one study, coughing and throat clearing taken together only resulted in a very small portion of patients having reflux disease (4). Having one of these two symptoms showed a slightly higher risk of reflux, but very modest.

Let’s look at some of the research.

Though PPIs may increase the risk of a number of complications, keep in mind that none of the data are from randomized controlled trials (RCTs), which are the gold standard of studies, but mostly observational studies that suggest an association, but not a link. Long-term RCTs to determine side effects are prohibitively expensive.

PPI and kidney disease

Recent research has tied proton pump inhibitors to a host of alarming health problems. Stock photo

In two separate studies, results showed that there was an increase in chronic kidney disease with prolonged PPI use (5). All of the patients started the study with normal kidney function based on glomerular filtration rate (GFR). In the Atherosclerosis Risk in Communities (ARIC) study, there was a 50 percent increased risk of chronic kidney disease, while the Geisinger Health System cohort study found there was a modest 17 percent increased risk. The first study had a 13-year duration, and the second had about a six-year duration. Both demonstrated a modest, but statistically significant, increased risk of chronic kidney disease.

 But as you can see, the medications were used on a chronic basis for years. In an accompanying editorial to these published studies, the author suggests that there is overuse of the medications or that they are used beyond the resolution of symptoms and suggests starting with diet and lifestyle modifications as well as a milder drug class, H2 blockers (6).

PPI and bone fractures

In a meta-analysis (a group of 18 observational studies), results showed that PPIs can increase the risk of hip fractures, spine fractures and any-site fractures (8). Interestingly, when it came to bone fractures, it did not make a difference whether patients were taking PPIs for more or less than a year. How much less than a year was not delineated. They found increased fracture risks of 58, 26 and 33 percent for spine, hip and any site, respectively. It is not clear what may potentially increase the risk; however, it has been proposed that it may have to do with calcium absorption through the gut. 

PPIs reduce the amount of acid, which may be needed to absorb insoluble calcium salts. In another study, seven days of PPIs were shown to lower the absorption of calcium carbonate supplements when taken without food (9).

PPI and dementia

Stock photo

A German study looked at health records from a large public insurer and found there was a 44 percent increased risk of dementia in the elderly who were using PPIs, compared to those who were not (7). These patients were at least age 75. The authors surmise that PPIs may cross the coveted blood-brain barrier and have effects by potentially increasing beta-amyloid levels, markers for dementia. With occasional use, meaning once every 18 months for a few weeks to a few months, there was a much lower increased risk of 16 percent. 

The researchers also suggested that PPIs may be significantly overprescribed in the elderly. Unfortunately, there were confounding factors that may have conflated the risk, such as multiple drug use, having diabetes, or patient also having depression or a stroke history. Researchers also did not take into account family history of dementia, high blood pressure or excessive alcohol use, all of which have effects on dementia occurrence.

Need for magnesium

PPIs may have lower absorption effects on several electrolytes including magnesium, calcium and B12. In one observational study, PPIs combined with diuretics caused a 73 percent increased risk of hospitalization due to low magnesium (10). Diuretics are water pills that are commonly used in disorders such as high blood pressure, heart failure and swelling.

Another study confirmed these results. In this second study, which was a meta-analysis (a group of nine studies), PPIs increased the risk of low magnesium in patients by 43 percent, and when researchers looked only at higher quality studies, the risk increased to 63 percent (11). The authors note that a significant reduction in magnesium could lead to cardiovascular events.

The bottom line is even though some PPIs are over-the-counter and some are prescription medications, it is best if you confer with your doctor before starting them. You may not need PPIs, but rather a milder medication referred to as H2 blockers (Zantac, Pepcid). Even better, start with lifestyle modifications including diet, not eating later at night, raising the head of the bed, losing weight and stopping smoking, if needed, and then consider medications (12). If you do need medications, know that PPIs don’t give immediate relief and should only be taken for a short duration: 7 to 14 days, according to the FDA (13), without a doctor’s consult, and 4 to 8 weeks with one. Most of the problems occur with long-term use.

References:

(1) cdc.gov. (2) PLoS Med. 2014;11(9):e1001736. (3) protonix.com. (4) J Clin Gastroenterol. Online Jul 18, 2015. (5) JAMA Intern Med. 2016;176(2). (6) JAMA Intern Med. 2016;176(2):172-174. (7) JAMA Neurol. online Feb 15, 2016. (8) Osteoporos Int. online Oct 13, 2015. (9) Am J Med. 118:778-781. (10) PLoS Med. 2014;11(9):e1001736. (11) Ren Fail. 2015;37(7):1237-1241. (12) Am J Gastroenterol 2015; 110:393–400. (13) fda.gov.

Dr. Dunaief is a speaker, author and local lifestyle medicine physician focusing on the integration of medicine, nutrition, fitness and stress management. For further information, visit www.medicalcompassmd.com or consult your personal physician. 

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Cleome ‘Lavender Sparkler’ deters the deer.
A beautiful dahlia ‘Karma Choc’
A bouquet of cosmos and zinnias
Cosmos catching morning rays
Scarlet sage provides a jolt of color to a mixed border.

By Kyrnan Harvey

Successful perennial plantings present landscaping solutions that endure for a few years at a minimum: right plant, right place. Yarrows, peonies, echinaceas, catmint, sages and grasses of all kinds are dependable year-in, year-out, with no worries that the deer will compromise the peak of their performance with unpredictable browsing.

But what about annuals? What possibilities are there for long seasons of color that deliver a strong return on our efforts, and that the deer will dependably leave alone? Here’s a few that my wife and I have successfully grown in our East Setauket garden, which happens to be Grand Central Station for deer. These plants supply many weeks of color and character and carry the garden from July through October, and they too can be counted on as year-in, year-out solutions. These here all require plenty of sun, so if you haven’t got enough, maybe it’s time to call an arborist and remove some Norway maples, Ailanthus (tree of heaven) or black locust.

Snapdragons flower in early summer. They are charming in a vase and there are some great colors out there. They self-seed for us and occasionally overwinter. We like the taller ones; the deer don’t.

Nor do they touch cosmos or zinnias. The former are charming daisies, the embodiment of simplicity in the garden; the latter have the colors that remind me of vintage psychedelic rock posters. Buy them at the garden center or start seeds in April. We prefer the tall zinnia seed strain, Giant. Dead-head spent flowers, especially the zinnias.

We love lantana. Readily available, we have certain varieties in certain colors that we look out for. The Bandana series is upright and not trailing. They are actually perennial, woody shrubs, native in the tropics and thus not hardy. Vibrantly colored, heat and drought tolerant, aromatic, they attract hummingbirds and butterflies. 

We started years ago supplementing clients’ sunny beds with them, and we’d cut them back to about a foot in early November; dig them up and squeeze them into as small an azalea pot (broader than deep) as possible; water them in just once; leave them a day or two outside; and leave them alone to be dormant in a cold (but not freezing) garage or basement. We try to place them where there is a window, just a tiny bit of light, let them get good and dry, and water only every three or four weeks. We move them outside in May, they start growing, and by late May they are planted out again. They get larger from year to year, but we still pot them up, not without questioning our sanity, and are rewarded with lantanas a yard high and wide — a splendid filler after spring and early summer perennials are finished.

One might expect zaftig dahlias to be irresistible to deer, but astonishingly they are unmolested. My wife has become the in-house dahlia enthusiast at Bosky Garden Design, adding each year to her collection of favorites. And there are indeed so many gorgeous varieties. The best cut flowers, you can grow them just for that, or they are easily incorporated in mixed planting schemes, color combination possibilities are endless. We overwinter them, again in a cold basement, bare of soil, wrapped first in newspaper and placed in those 5-cent plastic bags with peat moss.

We love the shock of red of scarlet sage, if used wisely (i.e., segregated), but salvias of all kinds are avoided by deer. Salvia greggii is sold as an annual, but some varieties will be perennial given favorable conditions. This is a plant to look for; there is a wide range of colors, some hardier than others.

Cleome will self-seed prolifically, not until late May. Sparkler is a great seed strain that is tall and that repels deer for sure.

Last, and certainly not least, we have Verbena bonariensis, a short-lived perennial, technically, that succumbs to temperatures below 10 degrees but that self-seeds more abundantly than even cleome. For us it is a tall matrix plant that intermingles everywhere in the garden. Loved by butterflies, loathed by deer, it epitomizes and unifies the naturalistic planting style.

Kyrnan Harvey is a horticulturist and garden designer residing in East Setauket. For more information, visit www.boskygarden.com.

All photos by Kyrnan Harvey

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SWEET GETUP

Ellen Segal of Port Jefferson spotted this candy dress in the storefront window of Carl’s Candies on a recent visit to Northport’s Main Street and just had to stop and snap a photo. The outfit, with a top made of gummy bears, a belt of gumballs and lollipops, a skirt made of candy button sheets and twizzler shoes, is as sweet as sugar.

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Disney’s ‘The Little Mermaid’ will be screened at the Crab Meadow Beach Drive-In on July 19.

By Sabrina Petroski

Mark your calendars! With the beautiful summer weather comes another season of free outdoor movie screenings for families on the North Shore. Parks, beaches and other outdoor spaces will magically transform into theaters, presenting a mix of animated films, current releases and family favorites.

Councilman Mark Cuthbertson (D) and the Town of Huntington recently announced this year’s schedule for its annual Movies on the Lawn event. Now in its 14th year, four movies, handpicked by the councilman himself, will be shown over the course of the summer at various locations in the town for free.  

“We are excited to bring you another great lineup of movies this summer. Pack your picnic dinner, blankets and lawn chairs and enjoy this summer’s lineup,” said Cuthbertson. 

This year’s program includes “Jumanji: Welcome to the Jungle” at Heckscher Park, 2 Prime Ave., Huntington on June 25 (rain date July 16); “Star Wars: The Last Jedi” at Crab Meadow Beach Drive-In, Waterside Ave., Northport on Thursday, July 5 (rain date July 31); Disney’s “The Little Mermaid” at Crab Meadow Beach Drive-In on Thursday, July 19 (rain date July 31); and “Despicable Me 3” at Peter Nelson Park, Oakwood Road, Huntington on Aug. 13 (rain date is Aug. 20).  

A sandcastle contest and basketball shoot off will be held on July 19 before the movie. All movies will begin at dusk. 

According to Cuthbertson’s office, no alcohol is allowed at any of the events. If a showing is rained out, the event will be moved to the listed rain date and be shown indoors at Walt Whitman High School, 301 West Hills Road in Huntington Station at 7:30 p.m.

For more information about the movies, including updates, visit https://huntingtonny.gov/moviesonthelawn2018 or call 631-351-3112. 

More free outdoor movie offerings:

•The St. James Chamber of Commerce will host a Movie Night at Deepwells Farm County Park, located at the corner of Route 25A and Moriches Road, St. James on July 17, with “Coco” and Aug. 21 (updated) with “Breaking Legs.” Movies begin at 7:45 p.m. Call 631-584-8510 or visit www.stjameschamber.org for updates.

•Grumman Memorial Park, Route 25, Calverton will screen “Top Gun” on Aug. 3 at 8:30 p.m. Call 631-727-574 or visit www.riverheadrecreation.net for further info.

•Hoyt Farm Park Preserve, 200 New Hwy., Commack will screen “Beauty and the Beast” on Aug. 3 at 8:30 p.m. (rain date is Aug. 10). Alternate street parking is available for nonresidents of Smithtown. For more information, call 631-543-7804 or visit www.smithtowninfo.com.

•North Shore Heritage Park, 633 Mount Sinai-Coram Road, Mount Sinai, resumes its annual Movies in the Moonlight series on July 6 with “Jumanji: Welcome to the Jungle,” July 20 with “The Incredibles” and Aug. 17 with “Toy Story 3.” Sponsored by Heritage Trust, all movies begin at dusk (approximately 8:15 p.m. Bring a blanket or chair. Movie refreshments will be available at The Shack concession. No rain dates. Questions? Visit www.msheritagetrust.org, or call 631-509-0882.

•The Village of Port Jefferson’s Movies on the Harbor returns to the Jeanne Garant Harborfront Park, 101 East Broadway, Port Jefferson on July 10 with “Willy Wonka & The Chocolate Factory,” July 17 with “Wonder,” July 24 with “Star Wars: The Last Jedi” (updated),  July 31 with “Cars 3”  and Aug. 7 with “Coco.” Movies begin at dusk and the rain date is the next evening. For additional info, call 631-473-4724 or visit www.portjeff.com.

•Movies Under the Stars returns to Smith Haven Mall’s Lifestyle Village (located next to Dick’s Sporting Goods), Lake Grove, with a screening of “Moana” on Aug. 6, “Justice League” on Aug. 13, “Coco” on Aug. 20 and “A Wrinkle in Time” on Aug. 27. Call 631-724-1433 or visit www.simon.com for updates.

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File photo by Rachel O'Brien

Join the Lake Ronkonkoma Improvement Group in keeping Lake Ronkonkoma clean during the Great Brookhaven Cleanup on Saturday, June 16. Volunteers will meet at the Town of Brookhaven’s Michael P. Murphy Beach on Lake Shore Road from 9:30 a.m. to 3 p.m. and walk the shoreline of the lake picking up litter. Students are welcome to use this event for community service hours. Come spend an hour or two making the lake as beautiful as it should be! For further details, call Evelyn at 631-588-7599.

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The cover of Philip F. Palmedo's latest book, a tribute to his late father

Reviewed by Elizabeth Kahn Kaplan

“Roland Palmedo: A Life of Adventure and Enterprise” looks behind the extraordinary achievements of a 20th-century pioneer in the development of skiing in this country.

Author Philip F. Palmedo

Several previous books by the author, St. James resident Philip F. Palmedo, delved into the relationship between sculptors’ lives and their work. Turning now to a subject closer to his heart, in this biography Philip explores and illuminates the traits that propelled his father to be “an exemplar of an uncommon adventurous life that has become all too rare.” 

Written 40 years after Roland’s death, Philip provides more than details about his father’s adventures and accomplishments. 

He reveals his father’s deeply held values and the philosophy that propelled him to create lasting institutions of benefit to many. 

Born April 5, 1895, in Brooklyn, Roland was encouraged by his mother to explore Europe after high school. Visiting cousins in the German Alpines, he experienced a life in forests and mountains for the first time. Love of nature underpinned much of what he did afterward and formed a fundamental part of his character. He fell in love with skiing. Upon his return, he chose Williams College in the Berkshires, which had a ski team. He founded the Outing Club to share his love of sports with fellow student enthusiasts. This was a pattern he would follow; organizing clubs as the best way for an amateur to engage in his sport with others. 

Roland was an advocate of amateurism, with separate races for amateurs and professionals in domestic and international competitions. He believed that the structure of amateur sport should give maximum encouragement to participation. College students, business people, doctors and other professionals ought to be able to enter state and national championships. A participant sport offers a great public benefit, rather than an entertainment for spectators. All the sports he loved — skiing, bicycling, kayak racing, mountain climbing — he looked upon as character building.

In the 1920s New England had no plowed roads and few accommodations in winter. Roland led friends from New York City on skiing expeditions to snowy trails and logging roads in the Berkshires and Vermont. Recreational skiing was little known. 

Roland Palmedo on a kayaking trip. Photo from Philip F. Palmedo

Arguing that it could best be encouraged in clubs, he formed the Amateur Ski Club of New York in 1931. Its members supported Roland in organizing and sponsoring the first U.S. Women’s Ski Team at the 1936 Winter Olympics.  The club was behind him in developing two ski areas in Vermont — Stowe during the 1930s, on Mount Mansfield, Vermont’s highest mountain; and Mad River Glen in the late 1940s.  Roland initiated the Mount Mansfield Ski Lift Company at Stowe to build and operate a single-chair lift that served skiers for half a century after its opening in 1940.

Stowe became the number one ski resort in the East. When the crowds and hotels and night clubs followed, Roland sought virgin terrain in the Mad River Valley of the Green Mountains. With others he created Mad River Glen. He led a trail design team designing interesting, narrow trails that guided a skier to “experience nature’s particularities.” The nature-respecting trails were the reason for Mad River’s reputation as an expert’s mountain; bumper stickers declared, “Ski It If You Can.” Roland was determined to retain the love and joy of the sport. At his insistence, Mad River Glen was designed to keep all but serious skiers away: “No hotels; just a few homey inns; no nightlife, except of the most home-spun country sort.” It is still a favorite of amateur skiers attracted by the untouched nature of the area.  

Without his financial expertise, neither Stowe nor Mad River Glen would have come to be. Similarly, he used his business organizational skills at Lehman Brothers in the 1920s to create aviation companies. Roland served on several aviation company boards, including Pan Am. He remained with Lehman Brothers until the 1960s.

The cover of Philip F. Palmedo’s latest book, a tribute to his late father

The U.S. Naval Air Force was in its infancy when Roland became a member of the first air squadron, in 1917. He flew air patrols with the RAF. Returning to civilian life, he continued flying out of the now-defunct Long Island Aviation Country Club in Hicksville. He compared flying with skiing, for in both you interacted directly with and controlled the forces of nature. He flew open-cockpit planes, including a Stearman biplane, from Manchester, Vermont, to New York in 1939. Four months after Pearl Harbor, he re-enlisted in the U.S. Naval Airforce. Lt. Commander Roland Palmedo served on the aircraft carrier Yorktown near the coast of Japan.

Many sons and daughters of men with distinguished careers and all-consuming personal passions have felt the loss of a warm companion and a strong guiding hand. Not so with Roland Palmedo. He taught his sons to ski and play tennis and provided adventures from white-water kayaking trips to expeditions to Europe and to Chile.

Philip appreciated Roland as a patient and loving grandfather. Roland’s granddaughter, Philip’s niece Bethlin “Scout” Proft, lives in the mountainside house that Roland rebuilt in the 1930s as “the first ski chalet in Vermont.” She created and runs a working farm there, in East Dorset. Scout quotes her granddad when she says, “Leave the world a better place.”

Roland died just before his 82 birthday on March 15, 1977. Philip regrets that he did not ask his father what it was like to fly rickety biplanes, to explore Mount Mansfield before there were lifts and to create aviation companies in the 1920s.

 Perhaps those of us still lucky to have a father with whom we can celebrate this coming Father’s Day may wish to ask a few important, revealing questions. Both of you will profit.

“Roland Palmedo: A Life of Adventure and Entreprise,” Peter E. Randall Publisher, is available online at Amazon.com or from its distributor at www.enfielddistribution.com. For more information on the author, visit his website at www.philippalmedo.com.

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From left, Evan Sohn, co-founder of the Sohn Conference Foundation; Benjamin Martin, associate professor at Stony Brook University; and Bill Ackman, co-founder of the Pershing Square Foundation and CEO of Pershing Square Capital Management at an awards dinner. Photo by Melanie Einzig/PSSCRA

By Daniel Dunaief

Up and coming scientists are often stuck in the same position as promising professionals in other fields. To get the funding for research they’d like to do, they need to show results, but to get results, they need funding. Joseph Heller, author of “Catch 22,” would certainly relate.

A New York-based philanthropy called the Pershing Square Sohn Cancer Research Alliance is seeking to fill that gap, providing seven New York scientists with $600,000 each over the course of three years.

In the fifth annual competition, Benjamin Martin, an associate professor in the Department of Biochemistry & Cell Biology at Stony Brook University, won an award for his study of zebrafish models of metastatic cancer. Martin is the first Stony Brook researcher to win the prize.

Working with Assistant Professor David Matus, whose lab is across the hall and whose research team conducts weekly group meetings with Martin’s lab, Martin is able to see in real time the way grafted human tumor cells spread through blood vessels to other organs in the transparent zebrafish.

“It’s been very challenging to understand what process cancer cells are using to metastasize and leave the blood vessels,” said Olivia Tournay Flatto, the president of the Pershing Square Foundation. “With this technology, he can see what’s happening. It’s a really powerful tool.”

The work Martin presented was “really appealing to the whole board, and everybody felt this kind of project” had the potential to bring data and insights about a process researchers hope one day to slow down or stop, said Flatto.

This year, about 60 early-stage investigators applied for an award given specifically to researchers in the New York City area. When he learned that he won, Martin said, “There was some dancing going on in the living room.” He suggested that the award is a “validation” of his research work.

The process of a cancer cell leaving a blood vessel is “basically a black box” in terms of the mechanism, Martin said. It’s one of the least understood aspects of metastasis, he added.

Indeed, a developmental biologist by training, Martin is hoping to discover basics about this cancer-spreading process, such as an understanding of how long it takes for cancer cells to leave blood vessels. The process can take hours, although it’s unclear whether what he’s seen is typical or abnormal.

Martin would like to identify how the cancer cells adhere to the blood vessel walls and how and why they leave once they’ve reached their target.

Metastatic cancer is likely using the same mechanism the immune system uses to travel to the sites of infection, although researchers still need to confirm several aspects of this model.

Moving in involves interactions with white blood cells, including macrophages. With white blood cells, an area of infection or inflammation becomes activated, which triggers a reaction of adhesion molecules called selectins.

By watching a similar transport process in cancer, Martin and Matus can “see things people haven’t seen before” and can explore way to inhibit the process, Martin suggested.

He is hoping to find ways to stop this process, forcing cancer cells to remain in the blood vessels. While he doesn’t know the outcome of a cancer cell’s prolonged stay in the vessel, he predicts it might end up dying after a while. This approach could be combined with other therapies to force the cancer cells to die, while preventing them from spreading.

Through this grant, Martin will also study how drugs or mutations in selectins generate a loss of function in these proteins, which affects the ability of cancers to leave the blood vessel.

Martin plans to use the funds he will receive to hire more postdoctoral researchers and graduate students. He will also purchase additional imaging equipment to enhance the ability to gather information.

Martin appreciates that this kind of research, while promising, doesn’t often receive funding through traditional federal agencies. This type of work is often done on a mouse, which is, like humans, a mammal. The enormous advantage to the zebrafish, however, is that it allows researchers to observe the movement of these cancer cells, which they couldn’t do in the hair-covered rodent, which has opaque tissues.

“There’s a risk that these experiments may not work out as we planned,” Martin said. He is hopeful that the experiments will succeed, but even if they don’t, the researchers will “learn a great deal just from seeing behaviors that have not been observed before.”

Indeed, this is exactly the kind of project the Pershing Square Sohn Cancer Research Alliance seeks to fund. They want scientists to “put forward the riskiest projects,” Flatto said. “We are ready to take a chance” on them.

One of the benefits of securing the funding is that the alliance offers researchers a chance to connect with venture capitalists and commercial efforts. These projects could take 20 years or more to go from the initial concept to a product doctors or scientists could use with human patients.

“We are not necessarily focused on them starting a company,” Flatto said. “We think some of those projects will be able to be translated into something for the patient,” which could be through a diagnosis, prevention or treatment. “This platform is helpful for young investigators to be well positioned to find the right partners,” he added.

Aaron Neiman, the chairman of the Department of Biochemistry & Cell Biology at SBU, suggested that this award was beneficial to his department and the university.

“It definitely helps with the visibility of the department,” Neiman said. The approach Matus and Martin are taking is a “paradigm shift” because it involves tackling cells that aren’t dividing, while many other cancer fighting research focuses on halting cancer cells that are dividing.

Neiman praised the work Martin and Matus are doing, suggesting that “they can see things that they couldn’t see before, and that’s going to create new questions and new ideas,” and that their work creates the opportunity to “find something no one knew about before.”

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Marinated Roast Pork Tenderloin

By Barbara Beltrami

There’s Dad, dear man, beer, martini or wine glass in one hand, fork, tongs or spatula in the other, standing in a rather large cloud of black smoke grilling our dinner. Nobody does it better. We know that and so does he, so how can we not let him do it almost every night? 

But on Fathers Day we have to draw the line. Even though he cooks those steaks to perfection, even though he’s got the magic formula for getting the chicken crispy on the outside and tender on the inside, we can’t have him slaving over a hot grill on his special day. Am I suggesting that we do the barbecuing? Of course not. We understand that the grill is his special territory. I’m just saying that we have to cook for him and pamper him so he knows how much we love him, the greatest grillmeister of all.

So what do we do? We make him a sumptuous but easy meal without the grill.  First we marinate a pork tenderloin for a few hours in the fridge, then remove it and cook it for a short time in the oven. Next we chill Dad’s drink(s) and park him in a lounge chair, microwave some enormous russet potatoes and we toss together a big salad with everything we can think of in it. Dessert has been made and frozen the night before, and we’re so organized that we can spend most of our time waiting on Dad hand and foot. After all, doesn’t he deserve it?

Marinated Roasted Pork Tenderloin

Marinated Roast Pork Tenderloin

INGREDIENTS:

One 2-pound pork tenderloin (they often come two in a package so you can cook one and freeze the other or cook both and use the second one for leftovers, sandwiches, etc.)

¼ cup balsamic vinegar

¼ cup olive oil

1 tablespoon prepared mustard

1 tablespoon A-1 sauce

1 tablespoon chopped fresh tarragon leaves or 1 teaspoon dried

2 cloves garlic, minced

Coarse salt and freshly ground black pepper, to taste

DIRECTIONS: 

In a small bowl combine the vinegar, oil, mustard, A-1 sauce, tarragon, garlic, salt and pepper. Transfer to gallon-size re-closable plastic bag. Place tenderloin in a U-shape in bag, seal and turn bag in several directions to be sure all the meat is coated. Refrigerate in marinade at least two hours, open bag and rotate meat so all parts of it have a chance to soak in the marinade. Refrigerate one hour more.  

Preheat oven to 475 F. Place meat and marinade in a shallow roasting pan. Roast 25 minutes for pork that is slightly pink inside or 30 to 35 minutes for more well done. Let tenderloin rest for 15 minutes, then place on a cutting board and slice into 1-inch-thick rounds. Serve with baked potatoes with sour cream and/or butter.

The Everything Salad

YIELD: Makes 6 servings

INGREDIENTS:

1 head red leaf or green leaf lettuce, washed and torn into bite-size pieces

1 large tomato, diced

1 green bell pepper, diced

1 medium cucumber, peeled, seeded and diced

1 cup chopped fennel

4 radishes, washed, trimmed and sliced

4 scallions, washed, trimmed and sliced

6 frozen artichoke hearts, cooked and quartered

2 medium carrots, peeled and shredded

1 medium fresh beet, peeled and shredded

1 cup cooked and sliced asparagus or string beans

1 cup frozen peas, thawed

¾ cup canned chick peas, washed and drained

½ cup extra virgin olive oil

¼ cup good wine vinegar

1 tablespoon prepared mustard

1 tablespoon mayonnaise

Salt and freshly ground black pepper to taste

1 handful basil leaves, chopped

3 tablespoons chopped fresh dill 

10 black olives, pitted and sliced

2/3 cup crumbled Roquefort, blue or goat cheese, crumbled

½ cup sunflower seeds

4 hard boiled eggs, sliced

DIRECTIONS: 

In a large bowl, combine lettuce, tomato, green pepper, cucumber, fennel, radishes, scallions, artichoke hearts, carrots, beet, asparagus, green peas and chick peas; toss well. In a small bowl, whisk together the olive oil, vinegar, mustard, mayonnaise, salt and pepper. Drizzle mixture over tossed veggies; toss again to coat evenly. Arrange or evenly distribute the basil, dill, olives, cheese, sunflower seeds and eggs on top. Serve immediately at room temperature with crusty bread and unsalted butter.


Frozen Banana Split Pie

YIELD: Makes 8 to 10 servings

INGREDIENTS:

6 to 8 brownies

1½ cups vanilla ice cream, softened

1½ cups chocolate ice cream, softened

1½ cups strawberry ice cream, softened

1 cup sliced fresh strawberries

1 large banana, sliced

1/3 cup chocolate syrup

2 cups sweetened whipped cream

DIRECTIONS: 

In a 9-inch pie plate, mash, crush and press brownies into bottom and sides. Spread the vanilla ice cream over the brownie crust, then repeat with chocolate ice cream and finally strawberry ice cream.  Cover with plastic wrap and freeze for at least 4 hours, preferably overnight. When ready to serve, remove from freezer, uncover and spread sliced strawberries and bananas over top; let sit 10 to 15 minutes to soften. Drizzle chocolate syrup over top, then drop dollops of whipped cream over fruit and chocolate. 

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Photo courtesy of Kent Animal Shelter

MEET HAPPI!

Photo courtesy of Kent Animal Shelter

What a smile! Meet the happiest dog ever, Happi! Rescued from a dire situation in Caymen Islands, this playful and sweet 3-year-old potcake has landed at Kent Animal Shelter and is now waiting for a loving home to play and relax for the rest of her days. Could that be with you? Happi comes spayed, microchipped and up to date on all her vaccinations.

Kent Animal Shelter is located at 2259 River Road in Calverton. The adoption center is open from 10 a.m. to 4 p.m. every day. For more information on Happi and other adoptable pets at Kent, visit www.kentanimalshelter.com or call 631-727-5731. 

Update: Happi has been adopted!

 

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