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Ginger Dalton and Antoine Jones in a scene from 'Perfectly Normal'
Stephen Wangner, Antoine Jones and Suzie Dunn in a scene from "Perfectly Normal"
From left, Stephen Wangner, Michelle LaBozetta and Nicole Bianco in “Playlist to Have a Crisis To”
The cast in “The Making of Medea’s Medea”
Linda May in "The Making of Medeas Medea"
Steve Ayle, Linda May, Dylan Robert Poulos, Steven Uihlein and Ryan Schaefer in “Family by Numbers”
Douglas Quattrock and Ryan Schaefer in “For a Moment in the Darkness, We Wait”
Antoine Jones and TracyLynn Conner in “The Unforgivable Sin of Forgiveness”
The cast of Theatre Three's 22nd annual Festival of One-Act Plays

By Heidi Sutton

From Mainstage productions to children’s theater, to concerts and film screenings, comedy shows and improv, Theatre Three always has a lot to offer. However, it is the Festival of One-Act Plays that many look forward to each year with eager anticipation. 

Showcasing six original works selected from 425 submissions, the 22nd annual festival opened last weekend for a nine-performance run in the intimate setting of The Ronald F. Peierls Theatre on the second stage. 

Directed by Jeffrey Sanzel, each short play is exciting; some dark, some funny, some sad, with lots of twists and turns. It is the unknown, the unfamiliar that makes it all so entertaining to watch. 

The show kicks off with Tom Slot’s “Playlist to Have a Crisis To.” Teenager Alexis (Nicole Bianco) has just hit a burglar dressed in a Santa Claus suit (Stephen T. Wangner) with an encyclopedia and he’s on the floor unconscious. She calls her girlfriend Tanya (Michelle LaBozzetta)to come over to wait for the police to arrive. When the man wakes up he claims to be the real Santa Claus. He knows things only Santa would know, but everyone knows he’s only a legend, right? And if he is real, will Alexis always be known as the girl who beat up Father Christmas?

Next up is “For a Moment in the Darkness, We Wait” by Libby Leonard, the touching story of two gay men, the older Bernard (Douglas Quattrock) and teenager Connie (Ryan Schaefer) struggling to hide their sexual identity in New York City the 1940s. You feel their pain, their frustration and their sadness in this emotional performance. 

The mood lightens greatly with “Perfectly Normal” by J. Joseph Cox, a hilarious look at the changing workplace. Antoine Jones, Suzie Dunn, Steve Wagner, Nicole Bianco and Ginger Dalton star in this delightful comedy. There’s a new boss in town and we hear of the workplace changes from breakroom gossip. “He swept in here like the Gestapo!” Employees are disappearing, Human Resources is boarded up, cavity searches are being conducted, and the final blow, coffee has been replaced by tea. This is normal?

“Family by Numbers” by Arianna Rose is the heartbreaking story of a family that loses a son in a hiking accident. Beautifully written, it  begins when the parents first meet, get married, raise three boys and then struggle with their tragic loss and one less number. Powerful performances all around by Steve Ayle, Linda May, Dylan Robert Poulos, Steven Uihlein and Ryan Schaefer.

After intermission, Rich Orloff’s “The Unforgivable Sin of Forgiveness” takes the stage. A wife (TracyLynn Conner) confesses to her husband (Antoine Jones) that she has been having an affair for three years. His response? “I know.” Taken aback, the wife turns the tables and demands to know why he hasn’t let on that he knew all this time. “You lied to your wife when all these years I’ve been faithful six days out of seven?” she exclaims in disbelief.

The final and longest act, “The Making of Medea’s Medea” by Chas Belov, is where the production of Medea’s modern-day retelling of her own story of revenge is played out on Theatre Three’s Mainstage while being turned into a documentary. We meet Medea, Jason, the actors that play them, the actors that play the part of the employees at Theatre Three, psychologists, Greek playwrights and more. The entire cast takes part with special mention to Linda May as the heartbroken and vengeful Medea.

With an excellent lineup and incredible cast, this festival is not to be missed. Get yourself a ticket before they sell out.

Sponsored by Lippencott Financial Group, Theatre Three, 412 Main St., Port Jefferson will present the 22nd annual Festival of One-Act Plays through May 5. Running time is 2 hours with a 15-minute intermission. All seats are $20. To order, call 631-928-9100 or visit www.theatrethree.com.

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Muddy ground was covered in the footprints of young children as hundreds gathered for the annual Fling into Spring carnival at Heritage Park in Mount Sinai April 12-14. Kids, along with their parents, got the full carnival experience as they slid, spun, raced and even flew on weekend rides. The money raised from the event helps nonprofit Heritage Trust fund other events throughout the year.

All photos by Kyle Barr

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Cassandra LaRocco as Helen Keller and Jessica Mae Murphy as Annie Sullivan in a scene from ‘The Miracle Worker’ Photo by Peter Lanscombe, Theatre Three Productions Inc.

By Heidi Sutton

Currently playing on Theatre Three’s Mainstage is William Gibson’s play “The Miracle Worker,” the compelling story of Helen Keller and her teacher Annie Sullivan. Directed by Bradlee Bing, the show is leaving a lasting impact on all who are fortunate enough to see it. One of the standout performances is from Cassandra LaRocco who plays a young Helen. The 11-year-old from Brentwood captures the audience’s heart with her powerful performance. 

I recently had the opportunity to interview Cassandra about her Theatre Three debut and her challenging new role.

How did you get interested in acting?

Since I can remember, I’ve always enjoyed entertaining people and finding different ways to make people laugh. I found that it was fun to try and mimic the different characters on many of the TV shows I watched when I was younger. When my parents took me to see “Annie” on Broadway in 2013, I felt that I wanted to be just like the actors on that stage so I started taking acting classes, along with my dance classes, and found that I loved getting the chance to perform for an audience.

Why did you decide to audition for this role?

I decided to audition for this role because it seemed extremely interesting and I thought it would be a good learning experience. I knew it would be a challenge for me since most of my prior stage acting experience had been with musicals, where I got to sing and dance. 

Cassandra LaRocco as Helen Keller and Jessica Mae Murphy as Annie Sullivan in a scene from ‘The Miracle Worker’ Photo by Peter Lanscombe, Theatre Three Productions Inc.

Were you familiar with Helen Keller?

Yes, I wrote a book report about Helen’s life in fifth grade. I knew that she was an amazing woman who lost her sight and hearing at a very young age but learned to communicate with people by using finger spelling. She inspired so many people by showing how a person with disabilities can make a difference in the world. 

How did you prepare for this role? 

First, I watched the movie with Anne Bancroft and Patty Duke. I focused on the different expressions used by Patty Duke as she portrayed Helen, and then tried to figure out my own way to express what Helen must have felt when she wasn’t able to communicate her thoughts. Then I focused on not letting the sights and sounds around me be distracting. Each time I rehearsed with the cast at Theatre Three, I would clear my mind and only think of Helen and being in her world.

How do you enjoy working with the cast?

I really enjoy working with this cast because everyone is so much fun to be around and is extremely talented. Everyone has worked so hard, and I am proud to be part of the team.

What is it like working with the director?

I really enjoy working with Bradlee Bing. He explained to me very well how to portray the challenging role of Helen and he made me feel confident in my performance. Being in “The Miracle Worker” is an experience I will remember always, and I thank Bradlee for this wonderful opportunity.

Do you ever get nervous before the show?

I get nervous before each show, but once the show begins and I focus on being in my role, I get less nervous. Being on stage with the other actors and knowing that we worked so hard together helps me to feel confident each time I do a performance.

What is your favorite scene? 

My favorite scene is the food fight scene performed before the end of Act 1 with Jessica Murphy who plays Annie Sullivan. I enjoy it because of all the action that takes place and because it is really challenging. In this scene, Helen is extremely frustrated by the changes around her and not knowing how to express her thoughts. I get to portray this frustration by acting out in a temper tantrum, throwing spoons, spitting food, climbing the table, and trying to escape the room but I am locked in. I physically have to move around the stage a lot, but have to still behave as if I can’t see anything in front of me.

Do you think children should come see this show?

Yes, I do think children should come see the show because they can learn that despite the disabilities Helen Keller had, she was able to learn different ways to communicate her feelings and thoughts. If children learn about Helen Keller at a young age, maybe they can be inspired by what she accomplished, and it could help them to learn to never give up when they are in a difficult situation.

Have you taken any acting classes?

I have been attending classes and performing plays at the John W. Engeman Theater in Northport. I also take voice lessons at Cristina Music Studio in Huntington, and I have been taking dance lessons since I was 3. I currently practice ballet, tap, jazz, lyrical and pointe at June Claire Dance Studios in Babylon.

What other shows have you been in?

I played the role of July in “Annie” at the Engeman Theater in 2017 and over the past holiday season, I was a dancer in “The Nutcracker” at the Cultural Arts Playhouse in Syosset where I played one of Drosselmeyer’s dolls, and also performed in the scenes for Snowflakes, Arabian Coffee and Flowers.  Last fall, I performed as Andrina, one of Ariel’s sisters, in “The Little Mermaid Jr.” at the Engeman.

How do you feel when you get a standing ovation?

I feel happy because people enjoyed the show and my performance. It means to me that the audience made a connection with the story we are telling up on the stage, and that hopefully it will be something they remember for a long time.

What advice would you give to other kids who want to try acting?

Follow your dreams. You will meet many other kids and teachers who will make you feel confident. As you learn from others, you will become less and less nervous, and have more and more fun.

What is your favorite part about this show?

My favorite part has been meeting new people who helped me to be a better performer, and learning about what Helen Keller had to go through to understand our world without seeing or hearing. It has taught me to think of the differences that people may have, but that when people work together and have patience, almost any difficult situation can be overcome. 

Why should people come see the show?

People should come see “The Miracle Worker” because they get to experience how difficult Helen’s world was when she was young, and how it all changed when Annie Sullivan came to teach her. It gives people the opportunity to relate to Helen Keller and to realize that without someone that was a dedicated teacher who was not willing to give up, Helen may have been trapped forever in a dark and silent world. The play is about facing challenges and showing how people can help each other and change the world for the better.

Theatre Three, 412 Main St., Port Jefferson will present “The Miracle Worker” through April 28. Running time is 2 hours with a 15-minute intermission. The Mainstage season closes with “The Wizard of Oz” from May 18 to June 22. Tickets are $35 adults, $28 seniors and students, $20 children ages 5 and up. For more information or to order, call 631-928-9100 or visit www.theatrethree.com.

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Bobbie Johnson of Stony Brook is this year's winner!

Dear Readers, 

We recently held our fourth annual adult coloring contest and the response was overwhelming! We received many colorful entries from readers all along the North Shore who used many different types of medium including colored pencils and markers to create their masterpieces. 

Bobbie Johnson of Stony Brook is this year’s winner!

Susan Saviano of Selden and Beverly Gross of St. James added glitter to the butterfly wings and flower petals, Richard Melidosian used acrylic paints, Kristin Lubliner of Mount Sinai used glitter pens for her creation and Jean Fleischer of Coram had so much fun she submitted two entries! 

At 98 years young, Loretta Fafard of Port Jefferson and Dorothy Forbes of Northport did a beautiful job. Forbes’ daughter writes, “My mother worked for hours on this despite the arthritis in her hands. She loves the butterflies and flowers in the sketch. This was the perfect selection for her. Thank you for making those hours so enjoyable for her.”

Although it was extremely difficult to choose a winner as every entry was unique in its own way, the judges ultimately chose the coloring page by Bobbie Johnson of Stony Brook who edged out the competition with her incredible shading techniques. Bobbie receives a three-year subscription to any one of our six papers, courtesy of Times Beacon Record News Media.

And surprise, all other entries will receive a one-year subscription as a thank you for entering our contest. Congratulations to all!

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From left, Joe Martinez; St. Catherine of Siena’s Chief Operating Officer John Pohlman; St. Catherine of Siena’s President James O’Connor; and St. Catherine of Siena’s Director of Colon and Rectal Surgery Tara Martinez. Photo from St. Catherine of Siena

Habberstad BMW in Huntington hosted St. Catherine of Siena’s Cocktails for a Colorectal Cause event on March 27. Dr. Tara Martinez, director of Colon and Rectal Surgery, took the opportunity to use the unique space to raise awareness about the importance of screenings during Colorectal Cancer Awareness month, celebrated nationally during March. 

The special fundraising event was attended by St. Catherine’s senior and departmental leadership, medical staff and community members, many of whom were dressed in blue for the cause.

The two-hour cocktail party had a two-prong objective. The first was to raise awareness about the new American Cancer Society screening guidelines for colorectal cancer, which was moved from age 50 to 45 for both men and women in 2018. The second goal was to raise funds to support the hospital’s community service initiative to provide free colonoscopy screenings to underserved populations on Long Island.

“Colorectal screenings save lives and the earlier you are screened, the better your outcomes,” said Martinez. “Colorectal cancer affects men and women alike, so please be diligent about your health, and encourage your loved ones to get screened at the appropriate age.”

Martinez also took the opportunity to thank Habberstad BMW General Manager Jim McCarthy for supporting the medical center and joining such important dialogue

In addition to co-hosting the event in its showroom, the dealership sponsored the hors d’oeuvres and  donated raffle prizes, including a BMW Genuine Cruise M-Bike. The event’s raffle sales yielded $2,120, and Habberstad BMW also donated a percentage of all sales during the month of March to support free colonoscopy screenings to be provided by St. Catherine of Siena throughout the year. 

“The event was certainly fun, well attended and most importantly, it offered the unique opportunity for me to educate the community about updates in colorectal screenings. We look forward to doing it again next year,” said Martinez. For more information about colorectal screenings, please call 631-870-3444.

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Sachem Public Library, 150 Holbrook Road, Holbrook will host a Suffolk County One-Stop Employment Center Job Fair on Wednesday, April 17 from 10 a.m. to 1 p.m.

Representatives from AFLAC, Allstate, Amneal Pharmaceuticals, Arrow Security, CIRCOR, DiCarlo Food Service, East End Disabilities, East/West Industries, Express Employment Professionals, Family First Home Companions, HEAP, Home Care Solutions, Home Depot, Home Instead Senior Care, HW Staffing, Integrity Home Care, Jefferson’s Ferry, LI State Veterans Home, Liberty Moving & Storage, Life’s WORC, Luitpold Pharmaceuticals, Marcum Search, NY Life Insurance, NYS Troopers, Options for Community Living, Precious Lambs Childcare, Rockwell Collins, SCOPE, SCWA, Splish Splash, Suffolk County Civil Service, Supreme Screw Products, SYSCO, Titan Global, Triangle Building Products, Walmart, Well Life Network and Windowrama are scheduled to attend.

All are welcome and no registration is required. Bring copies of your resume and dress to impress! Call 631-588-5024.

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Photo from Whole Foods

BREAD BREAKING CEREMONY

Representatives from the Northeast Regional division of Whole Foods held an official bread breaking ceremony (their version of a ribbon cutting) for its new store in Commack on April 3. Located at 120 Veterans Memorial Highway, the new 45,000-square-foot store employs 200 full- and part-time team members and is open 8 a.m. to 10 p.m. daily.

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Lori Chan, standing, in the lab with doctoral student Jiabei He. Photo from SBU

By Daniel Dunaief

It’s like a factory that makes bombs. Catching and removing the bombs is helpful, but it doesn’t end the battle because, even after many or almost all of the bombs are rounded up, the factory can continue to produce damaging products.

That’s the way triple-negative breast cancer operates. Chemotherapy can reduce active cancer cells, but it doesn’t stop the cancer stem cell from going back into the cancer-producing business, bringing the dreaded disease back to someone who was in remission.

Scientists who stop these cancer stem cells would be doing the equivalent of shutting down the factory, reducing the possible return of a virulent type of cancer.

Lori Chan, an assistant professor in the Department of Pharmacological Sciences in the Renaissance School of Medicine at Stony Brook University, recently published research in Cell Death & Disease that demonstrated the role of a specific gene in the cancer stem cell pathway. Called USP2, this gene is overexpressed in 30 percent of all triple-negative breast cancers.

Inhibiting this gene reduced the production of the tumor in a mouse model of the disease.

Chan’s results “suggest a very important role [of this gene] in cancer stem cells,” Yusuf Hannun, the director of the Stony Brook University Cancer Center, explained in an email.

Lori Chan with her dog KoKo. Photo by Joshua Lee

Chan used a genetic and a pharmacological approach to inhibit USP2 and found that both ways shrink the cancer stem cell population. She used RNA interference to silence the gene and the protein expression, and she also used a USP2-specific small molecular inhibitor to block the activity of the USP2 protein.

With the knowledge that the cancer stem cell factory population needs this USP2 gene, Chan inhibited the gene while providing doxurubicin, which is a chemotherapy treatment. The combination of treatments suppressed the tumor growth by 50 percent.

She suggested that the USP2 gene can serve as a biomarker for the lymph metastasis of triple-negative breast cancer. She doesn’t know if it could be used as a biomarker in predicting a response to chemotherapy. Patients with a high expression of this gene may not respond as well to standard treatment.

“If a doctor knows that a patient probably wouldn’t respond well to chemotherapy, the doctor may want to reconsider whether you want to put your patient in a cycle for chemotherapy, which always causes side effects,” Chan said.

While this finding is an encouraging sign and may allow doctors to use this gene to determine the best treatment, the potential clinical benefit of this discovery could still be a long way off, as any potential clinical approach would require careful testing to understand the consequences of a new therapy.

“This is the beginning of a long process to get to clinical trials and clinical use,” Hannun wrote. Indeed, researchers would need to understand whether any treatment caused side effects to the heart, liver and other organs, Chan added. 

In the future, doctors at a clinical cancer center might perform a genomic diagnostic, to know exactly what type of cancer an individual has. Reducing the cancer stem cell population can be critically important in leading to a favorable clinical outcome.

A few hundred cancer cells can give rise to millions of cancer cells. “I want to let chemotherapy do its job in killing cancer cells and let [cancer stem cell] targeted agents, such as USP2 inhibitors, prevent the tumor recurrence,” Chan said. 

She urges members of the community to screen for cancer routinely. A patient diagnosed in stage 1 has a five-year survival rate of well over 90 percent, while that rate plummets to 15 to 20 percent for patients diagnosed with stage 4 cancer.

The next step in Chan’s research is to look for ways to refine the inhibitor to make it more of a drug and less of a compound. She is also interested in exploring whether USP2 can be involved in other cancers, such as lung and prostate, and would be happy to collaborate with other scientists who focus on these types of cancers.

For Chan, the moment of recognition of the value of studying this gene in this form of breast cancer came when she compared the currently used drug with and without the inhibitor compound. With the inhibitor, the drug becomes much more effective.

A resident of Stony Brook, Chan lives with her husband, Joshua Lee, who is working in the same lab. The couple, who have a 1½-year-old rescue dog from Korea named KoKo, met when they were in graduate school.

Concerned about snow, which she hadn’t experienced when she was growing up in Taiwan, Chan started her tenure at Stony Brook five years ago on April 1, on the same day a snowstorm blanketed the area. “It was a very challenging first day,” she recalled. She now appreciates snow and enjoys the seasonal variety on Long Island.

Chan decided to pursue a career in cancer research after she volunteered at a children’s cancer hospital in Taiwan. She saw how desperate the parents and the siblings of the patient were. In her role as a volunteer, she played with the patients and with their siblings, some of whom she felt didn’t receive as much attention from parents who were worried about their sick siblings.

“This kind of disease doesn’t just take away one person’s life,” Chan said. “It destroys the whole family.” When she went to graduate school, she wanted to know everything she could about how cancer works.

Some day Chan hopes she can be a part of a process that helps doctors find an array of inhibitors that are effective in treating patients whose cancers involve the overexpression of different genes. “It would be a privilege to participate in this process,” she said.

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Justin Zhang

Justin Zhang, a junior at Ward Melville High School in East Setauket, won first place in the 2019 Model Bridge Building Contest at the U.S. Department of Energy’s Brookhaven National Laboratory in Upton.

In this annual regional competition, coordinated by BNL’s Office of Educational Programs, high school students across Long Island design, construct and test model bridges made of basswood that are intended to be simplified versions of real-world bridges. Participants must apply physics and engineering principles to meet a stringent set of specifications. Their bridges are judged based on efficiency, which is calculated using the weight of the bridge and the amount of weight it can support before breaking or bending more than one inch. A separate award is given to the student with the most aesthetic design.

For this year’s competition, 132 students from 15 high schools registered bridges. Fifty-two students representing nine schools qualified. An awards ceremony to honor the winners was held at BNL on March 15.

Zhang, whose bridge weighed 12.75 grams and had an efficiency of 2819.03, was unable to attend the ceremony because he was participating in the New York State Science Olympiad. Zhang’s father accepted the award on his behalf.

“I had built bridges, towers, and, more recently, boomilevers (kind of like the arm at the end of a crane) as a participant on my school’s Science Olympiad team and I really love civil engineering,” said Zhang. 

“So, the Bridge Building Contest perfectly fit both my past experience and interests. Through the competition, I was able to improve upon the ideas that I had developed in years prior working on engineering challenges and apply some new things that I had learned. It was particularly challenging for me to adjust to all the specific rules involved in the construction process,” he explained.

Gary Nepravishta, a freshman at Division Avenue High School in Levittown, took second place with his bridge weighing 18.2 grams and having an efficiency of 1949.45.

With a mass of 13.88 grams and efficiency of 1598.68, the bridge built by senior William Musumeci of Smithtown High School East won third place. “I built one bridge and tested it to see where it broke, and then I used a computer-aided design program to make a stronger bridge.” said Musumeci, who will be attending Farmingdale University to study construction engineering.

Sophomore Benjamin Farina of John Glenn High School in Elwood won the aesthetic award for best-looking bridge.

An honorary award was given to retired BNL engineer Marty Woodle, who was recognized for his 40 years of service as a volunteer for the competition. 

“If you become an engineer, you are not necessarily trapped into one little aspect of science,” said Woodle. “The world is open to you to do some really fascinating work.”

Zhang’s and Nepravishta’s bridges have been entered into the 2019 International Bridge Building Contest, to be held in Baltimore, Maryland, in early April. For more information, visit www.science.energy.gov.

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Stock photo
Comparing Paleo and Mediterranean diets

By David Dunaief, M.D.

We have made great strides in the fight against heart disease, yet it remains the number one cause of death in the United States. Why is this? Many of us have the propensity toward heart disease. Can we alter this course, or is it our destiny?

A 2013 study involving the Paleo-type diet and other ancient diets suggests that there is a significant genetic component to cardiovascular disease, while another study looking at the Mediterranean-type diet implies that we may be able to reduce risk factors greatly. Most of the risk factors for heart disease, such as high blood pressure, high cholesterol, sedentary lifestyle, diabetes, smoking and obesity are modifiable (1). Let’s look at the evidence.

Genetic components

Researchers used computed tomography scans to look at 137 mummies from ancient times across the world, including Egypt, Peru, the Aleutian Islands and Southwestern America (2). The cultures were diverse, including hunter-gatherers (consumers of a Paleo-type diet), farmer-gatherers and solely farmers. Their diets were not vegetarian; they involved significant amounts of animal protein, such as fish and cattle.

Researchers found that one-third of these mummies had atherosclerosis (plaques in the arteries), which is a precursor to heart disease. The ratio should sound familiar. It seems to coordinate with modern times.

The authors concluded that atherosclerosis could be part of the aging process in humans. In other words, it may be a result of our genes. Being human, we all have a genetic propensity toward atherosclerosis and heart disease, some more than others, but many of us can reduce our risk factors significantly.

I am not saying that the Paleo-type diet specifically is not beneficial compared to the standard American diet. Rather, that this study does not support that, although validating the Paleo-type diet was not its intention. However, other studies demonstrate that we can reduce our chances of getting heart disease with lifestyle changes, potentially by following a Mediterranean-type diet with an emphasis on a plant-rich approach.

Mediterranean-type diet

A study about the Mediterranean-type diet and its potential impact on cardiovascular disease risk was published in the New England Journal of Medicine (3). Here, two variations on the Mediterranean-type diet were compared to a low-fat diet. People were randomly assigned to three different groups. The two Mediterranean-type diet groups both showed about a 30 percent reduction in the risk of cardiovascular disease, with end points including heart attacks, strokes and mortality, compared to the low-fat diet. This improvement in risk profile occurred even though there was no significant weight loss.

The Mediterranean-type diets both consisted of significant amounts of fruits, vegetables, nuts, beans, fish, olive oil and potentially wine. I call them “the Mediterranean diet with opulence,” because both groups consuming this diet had either significant amount of nuts or olive oil and/or wine. If the participants in the Mediterranean diet groups drank wine, they were encouraged to drink at least one glass a day.

The study included three groups: a Mediterranean diet supplemented with mixed nuts (almonds, hazelnuts or walnuts), a Mediterranean diet supplemented with extra virgin olive oil (at least four tablespoons a day) and a low-fat control diet. The patient population included over 7,000 participants in Spain at high risk for cardiovascular disease.

The strength of this study, beyond its high-risk population and its large size, was that it was a randomized clinical trial, the gold standard of trials. However, there was a significant flaw, and the results need to be tempered. The group assigned to the low-fat diet was not, in fact, able to maintain this diet throughout the study. Therefore, it really became a comparison between variations on the Mediterranean diet and a standard diet.

What do the leaders in the field of cardiovascular disease and integrative medicine think of the Mediterranean diet study? Interestingly there are two diametrically opposed opinions, split by field. You may be surprised by which group liked it and which did not. Cardiologists hailed the study as a great achievement. They included Henry Black, M.D., who specializes in high blood pressure, and Eric Topol, M.D. They emphasized that now there is a large RCT measuring clinical outcomes, such as heart attacks, stroke and death.

On the other hand, the integrative medicine physicians, Caldwell Esselstyn, M.D., and Dean Ornish, M.D., both of whom stress a plant-rich diet that may be significantly more nutrient dense than the Mediterranean diet in the study, expressed disappointment with the results. They feel that heart disease and its risk factors can be reversed, not just reduced. Both clinicians have published small, well-designed studies showing significant benefits from plant-based diets (4, 5). Ornish actually showed a reversal of atherosclerosis in one of his studies (6).

So who is correct about the Mediterranean diet? Each opinion has its merits. The cardiologists’ enthusiasm is warranted, because a Mediterranean diet, even one of “opulence,” will appeal to more participants, who will then realize the benefits. However, those who follow a more strict diet, with greater amounts of nutrient-dense foods, will potentially see a reversal in heart disease, minimizing risk — and not just reducing it.

Thus, even with a genetic proclivity toward cardiovascular disease, we can very much alter our destinies. The degree depends on the willingness of the participants.

References:

(1) www.uptodate.com. (2) BMJ 2013;346:f1591. (3) N Engl J Med 2018; 378:e34. (4) J Fam Pract. 1995;41(6):560-568. (5) Am J Cardiol. 2011;108:498-507. (6) JAMA. 1998 Dec 16;280(23):2001-2007.

Dr. Dunaief is a speaker, author and local lifestyle medicine physician focusing on the integration of medicine, nutrition, fitness and stress management.  

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