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Daniel Dunaief

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By Daniel Dunaief

Daniel Dunaief

When my daughter drives to a crosswalk and a pedestrian is crossing, she feels terrible if the person on foot starts to jog or sprint, pushing him or herself to move more quickly so my daughter can continue on her way.

My daughter also gets annoyed if the person suddenly slows down.

Life is full of those “just right” moments. If our hot chocolate is too hot, we risk burning the roofs of our mouths. If it’s too cold, it doesn’t have the desired effect of warming us up. 

It’s what makes the Goldilocks story so relatable. The father’s bed is too hard, the mother’s is too soft, but the baby’s bed is just right.

When my family searched for new beds, we collapsed into one mattress after another, imagining a good night’s sleep, just the right book or a good movie with perfectly balanced sound.

Most salespeople spend their careers trying to find the right fit for someone, whether it’s a shoe, bed, car, house or any of the myriad items that fill my email box overnight while I sleep.

Life involves the constant search for just right. If we won every game we played, the competition wouldn’t be strong enough and we wouldn’t push ourselves to get better. A movie with absolutely no adversity can be charming, but it can also wear thin quickly, as the lack of suspense can lead us to wonder whether a dystopian conflict is pending.

Even in the world of friendships, we search for just-right friends. We generally don’t seek friends who want to talk to us all the time, or who can barely make time for us. We also don’t want friends who agree with everything we say. A few people, public figures and otherwise, seem eager to find people who reinforce their brilliance regularly. I would prefer to find people with viewpoints that differ from my own, which force me to defend my ideas and allow me incorporate new perspectives into my thinking or behavioral patterns.

Just right for any one person can and often is different from just right for someone else, which enhances the notion that we can find someone who is a great match or complement for us.

Ideally, the non-just-right shoes, weather, girlfriends, boyfriends or jobs teach us more about ourselves. Why, we wonder, didn’t that work? Once we figure that out, we have a better chance at understanding what does.

Sometimes, like the bed that doesn’t feel comfortable at first but eventually becomes the only one that affords us a quality sleep, we grow into a role and find that the previous tasks or conversations, which had seemed so odious initially, are a much better fit than we originally thought, as a result of the changes in ourselves.

And, as Shakespeare wrote in Hamlet, “There’s the rub.” The pursuit of just right in any context can change as we age. Our high school tastes in music, clothing, cars, houses, jobs or any other choices can and do change with each landmark reunion, making it more difficult to know what we want or what we’re searching for.

While I share my daughter’s guilt when a pedestrian rushes across the crosswalk to let me go or prevents me from running down that person, I’m not as frustrated by someone who slows down. I try to determine, watching that person pause in the middle of the street, how this might be a “just right” moment for the pedestrian.

Hyunsik Kim and Erin Kang. Photo from Matthew Lerner’s lab

By Daniel Dunaief

This is the second half of a two-part series on autism research conducted by Hyunsik Kim and Erin Kang.

 Last week we focused on the work of Stony Brook University graduate student Hyunsik Kim, who used three criteria to diagnose autism. This week we will feature the work of another SBU graduate student in the Department of Psychology, Erin Kang, who specifically explored the types and severity of communication difficulties autistic children have. 

Words and the way people use them can offer clues about autism. Looking closely at pronoun reversals, speech delays, perseveration and 10 other characteristics, Kang determined that the number of features was a “powerful predictor of an autism spectrum disorder diagnosis.” 

In a paper published online in the Journal of Clinical Child & Adolescent Psychology, Kang grouped children from 6 to 18 years old into different subgroups based on their communication patterns and used a statistical method that allows the data to “speak for itself,” in terms of finding groups based on the patterns of how the communication difficulties are associated and to classify them.

According to Kang, heterogeneity is an important feature of autism spectrum disorder. “There has been a greater effort into understanding whether subgroups exist in ASD populations,” she explained in an email. By examining the atypical communication characteristics, she found four subgroups. These groups differed from each other, not only with autism, but on multiple measures, including the occurrence of anxiety or depression and with intellectual disabilities.

The communication difficulties occur at different rates within the autism children throughout Long Island that Kang studied.

Kang said her work has been “building on the previous literature,” although many of the previous studies focused on characterizing autism for children who were younger than 6.

“There are few studies on specific symptoms (e.g., stereotyped speech) across the body of literature,” she explained, adding that she’s passionate about exploring the trajectory of development over time with or without intervention. 

She and her co-authors, Ken Gadow and Matthew Lerner, who are also at Stony Brook University, are working on a follow-up paper that attempts to explore how changes in the pattern of communication challenges examined in the paper relate to other clinical aspects and outcomes.

Kang believes her results have clinical implications that will help in understanding autism. Atypical communication features are a good predictor of diagnostic status. “This can provide an advantage in assessing social communication profiles in autism,” she said. “It’s hopefully valuable in a low-resource setting.”

Parents might be asked 13 questions on a checklist, which could serve as an initial screening for more comprehensive autism evaluations, rather than a multiple checklist that could take a while for parents to complete. The different categories had specific features that distinguished them. 

“There’s been quite a bit of work in the speech and language field,” said Lerner, an associate professor of psychology, psychiatry and pediatrics in the Department of Psychology at Stony Brook University and Kang’s mentor. “This approach allowed us to ask about some of the specific types of language differences we often see.”

Lerner said what Kang found is that specific characteristics do tend to cluster together in “interesting and unique ways that can tell us more about the communicative phenotype of autism.”

One of the groups, which she called “little professors,” had speech patterns with considerable perseveration. In perseveration, a person repeats a word or phrase, even when a question or stimulus that might elicit that phrase no longer continues. As an example, Dustin Hoffman in the movie “Rain Man” frequently repeated the number of minutes until Judge Wapner was on TV.

“These kids would benefit more from a group-based social skills intervention that specifically integrated interacting with peers,” Kang said. People in this group had the highest percentage of wanting a friend, but difficulty with relating to peers.

“They will benefit especially from interventions that help them build skills in interacting with peers,” she explained.

She also suggested that the best way to make a reliable diagnosis is to collect as much information as possible, which could include observations and electrophysiological data.

Kang acknowledged that some of the responses from the parents or teachers of people with autism contain bias. “There can be a lot of potential especially in terms of these subjective measures,” she said.

Indeed, through Lerner’s lab, Kang has been trying to include more uses of neurological measures and other methodology that is less subject to biases.

“Hopefully, by looking at these more objective measures, we can help integrate information from these different levels,” she said.

A resident of East Northport, Kang lives with her husband, musician Sungwon Kim, who works as a freelancer on Broadway musicals. The couple, who have a young son, met in Boston when she was working at Boston Children’s Hospital and he was a student at Berklee College of Music. 

Kang’s first experience with autism was in high school, when she acted as a mentor to a second grader. When she entered college at the University of California at Berkeley, she studied molecular and cellular biology and psychology.

Lerner said that Kang is a “truly remarkable young scholar” and is “among the best I’ve seen at her stage to be able to look at her clinical experiences, which drive the questions that strike at the core of how we understand and treat autism.”

Lerner appreciates how she is driven to understand autism from neurons in the brain all the way up to the classification and treatment.

“She is somebody who is completely undaunted by taking on new questions or methodologies because she has an idea of what they’re going to mean,” Lerner said. “She has worked with [autistic children] and has tried to understand where they are coming from.”

Kang questions assumptions about what autism is, while also exploring its development.

“She is able to see and discover clinical strengths that manifest in the kinds of questions she asks,” explained Lerner. “She is a part of the next generation of where my field is going, and I hope we can catch up to her.”

Kang appreciates the work-life balance she has struck on Long Island, where she feels like the pace of life is “quiet and calm during the week,” while it’s close enough to New York City to enjoy the cultural opportunities.

By Daniel Dunaief

Daniel Dunaief

Wait, was that at me? How am I supposed to know? She’s still waving. I could wave back, but what if she’s waving to someone else. Should I put my stupid hand in the stupid air and risk the possibility of looking stupid?

Yes, this happened to me many times during my adolescence. How was I supposed to react when someone I kind of knew, or maybe wanted to know, was waving in my direction? Sometimes, I pretended I didn’t see the person waving, while I casually looked around to see if anyone near me was responding. I probably looked like I had a neck twitch, as I scanned the area to see if it was safe to wave.

These days, the waving conundrum has taken a different form, especially after we moved away from the tristate area. It appears that the Northeast and Southeast have different rules for waving. In the Northeast, we wave when someone we know well walks by us in the car. If they don’t see us, perhaps we offer a quick and polite tap on our horn, just to let them know we saw them and we’ll likely text or email them later.

If someone we’re pretty sure we don’t know waves, we immediately assume that someone else is the recipient of their gesture — they have a small dog on the loose and we better slow down, or their children are playing a Nerf gun game and might dart into the street. If they continue to wave, we squint for a while, trying to figure out if maybe they’ve lost weight. It could be they’re someone we might have met casually at one of our kids sporting events, or they want us to sign a petition, or even buy a product we’re sure we don’t need because we can’t stand all the crap we already have in our own house.

Of course, if we have our defensive curled upper-lip action going too quickly, we might scare away our son’s teacher, our daughter’s assistant coach or a new neighbor who has introduced herself to us four times.

In the Southeast, however, the rules are different. Most of the people in the passing cars wave when I walk the dog. Yes, we have a dog and, no, you can’t pet him even though he’s pulling as hard as he can to get to you because I have to bring him back inside so I can do some writing. I’ve stopped trying to figure out the source of the amicable gesture and I wave back. My son, who sometimes accompanies me on these dog walks, wondered, “Hey, do you know that person?” He is still playing by the rules of the Northeast.

I explained that I wave at every car, even the likely empty parked vehicles in case someone is sitting in them, because that’s what you do here. I told him I’ve conducted my own experiment, where I don’t wave and I see what happens. More often than not, the person slows down and waves even more vigorously, as if to say, “Hey, I’m waving here. Now it’s your turn.”

Kids in the modern era seem to have solved the waving problem. They do a quick head nod, which could be a response to a similar gesture from someone else or it could be a way of reacting to music no one else hears. Then again, they’ve probably figured out how to make a thinner, acne-free virtual version of themselves wave at cartoon versions of their friends.

From left, Hyunsik Kim, Associate Professor Matthew Lerner and Erin Kang. Photo from Lerner’s lab

By Daniel Dunaief

This is part one of a two-part series on autism research conducted by Hyunsik Kim and Erin Kang.

If someone in a family behaves in ways that are difficult to understand, the family might look for a support group of people with similar characteristics, visit a doctor or seek to document and understand patterns.

Finding a doctor who has seen these types of behaviors, speech patterns or actions before could provide comfort, as the physician may either engage in a course of treatment or provide context and understanding for the current behaviors. The doctor may also offer advice about any likely changes in behaviors in the near or distant future.

For researchers, understanding a range of symptoms, some of which might be below the threshold to meet a specific diagnosis, can lead to a more specific awareness of a condition, which could help guide patients toward an effective treatment.

Hyunsik Kim and Erin Kang, graduate students in the Department of Psychology at Stony Brook University, recently published papers examining autism, hoping to get a more specific understanding of subtle differences and symptoms.

Kim was looking for a better way to conceptualize autism. He used advanced statistical methods to compare three theoretical perspectives to find the one that best characterized the symptoms.

“According to my study, autism is not an all-or-nothing phenomenon, but is dimensional [and is] comprised of three related spectra of behaviors,” he explained. 

Researchers can characterize everyone’s autism symptoms through a combination of levels in each domain.

Each of these three areas can range from very mild to severe.         As an analogy, Kim suggested considering the quality of being introverted. A person can be mildly, moderately or highly introverted, which offers a continuum for the dimension of introversion.

In a dimensional approach that involves exploring these three different categories, researchers can get a better understanding of the symptom profiles.

“For decades, people thought of autism as purely categorical,” said Matthew Lerner, an associate professor of psychology, psychiatry and pediatrics in the Department of Psychology at Stony Brook University. “You either have it or you don’t. In fact, autism was thought of as the easiest diagnosis to make.”

Kim, however, has “a goal of answering the fundamental question: what are we talking about when we’re talking about autism?” Lerner said. “Slowly, autism has morphed from the most categorical to the most dimensional. Literally, people talk about the spectrum when they talk about autism.”

With a dimensional approach based on levels of the three major domains for diagnosing autism, Kim suggested that researchers and doctors could better understand people who fall just below the current diagnosis for autism.

“It’s especially important to identify individuals who show a borderline range of symptoms, who barely fail to meet the diagnostic criteria of a given disorder, and provide them with appropriate treatments,” Kim explained.

Ideally, he hopes a dimensional approach incorporates the severity of symptoms into the current diagnostic system to promote better treatment procedures and outcomes.

Kim recognized that he could have just as easily created a dimensional approach that incorporates a greater number of criteria. His statistical analysis, however, revealed that the three dimensions provide the parsimonious explanation about autism symptoms.

Kim analyzed data from a parent questionnaire. He recognized that self-reporting by parents may underestimate or overestimate the severity of symptoms. He believed the over and under estimate of symptoms likely “evened out.”

Lerner suggests this multidimensional approach has numerous implications. For starters, it can help capture more of the types of symptoms in a diagnosis. It can also highlight the specific area of autism a clinician might want to target.

“We should be focusing on the factors that are most relevant for the individual and which are getting in their way,” Lerner said.

Treating autism broadly, instead of focusing on specific symptoms, may be “misguided,” Lerner added. A more specific characterization of autism could also help advance the field of neurogenetic research. “With more contemporary genetic analysis, we can use findings like this as a road map for what those genetic differences mean,” he said.

For his next step, Kim hopes to expand this work to observational data, adding that to the existing pool of information from parental questionnaires.

“People go on a home visit and take video of autistic kids interacting with others,” Kim said. “We can have some people code their behavior.”

More broadly, Kim would like to answer fundamental questions about the classification and conceptualization of mental disorders by using advanced quantitative modeling and other data-driven approaches. He believes a factor may represent a person’s vulnerability to developing a specific mental disorder.

A high level of this factor, combined with life stressors or adversity, would make it more likely that a person develops a disorder. As someone who studies psychology, Kim said he is well aware of his own emotional patterns and he tries to use his training to help himself cope.

He is not particularly comfortable doing public speaking, but he tells himself that whatever anxiety he feels is normal and that his practice, knowledge and expertise should allow him to succeed.

A resident of Middle Island, Kim lives with his wife Jennifer. The couple has two young children. Kim describes his wife as a “really good” amateur baker, who bakes cakes, muffins, cookies, macaroons, chiffon cakes and more. He has encouraged her to start her own YouTube channel and one day they hope to open a bakery that is online and offline.

As for his autism work, he hopes the dimensional approach is “incorporated into the assessment stage so that individuals do not merely receive a diagnosis, but are informed of their unique symptom profiles, so that clinicians can take them into consideration.” 

By Daniel Dunaief

Daniel Dunaief

So, what was it like to be in Charlotte, North Carolina, Sunday during the?

For starters, employers warned their staff about heavy traffic around the Spectrum Center and about parking challenges. They suggested working from home on Friday and over the weekend, if possible, to avoid delays.

As a result, for the entire weekend, the car traffic around this manageable city seemed even lighter than usual. People couldn’t drive too close to the Spectrum Center, but it was nothing like Yankee Stadium or Citi Field before or after a game against a heated rival, or even against a middling team on a warm Saturday in July.

The city rolled out much tighter security than usual, putting up fences around a nearby bus station and restricting walking traffic into the outskirts of the stadium to ticket holders only. 

Once inside, I felt as if I had become a Lilliputian in “Gulliver’s Travels.” Men and women of all ages made 6 feet seem like a minimum height for admission. I felt like a kid who sneaks onto a ride at Disney World despite falling well below the clown’s hand that indicates “you must be this tall to enter.”

The clothing choices reflected a wide variety of fashion statements. Some had come to be seen, decked out in fine suits, flowing dresses and high-heeled shoes. Others strutted around in sweatpants and sweatsuits, donning the jerseys of their favorite players.

Celebrities walked among the commoners, much the same way they do at the U.S. Open. Several people approached a slow-moving and frail-looking Rev. Jesse Jackson to shake his hand. Jackson later received warm applause from the crowd when he appeared on the jumbotron large-screen display.

As taller teenagers, who were well over 6 1/2 feet tall, brushed past us, we wondered whether we might see any of them at this type of event in the next decade. They were probably thinking, and hoping, the same thing.

The game itself, which was supposed to start at 8 p.m., didn’t commence until close to 8:30, amid considerable pomp and circumstance.

The crowd saluted each of the players as they were introduced. The roar became considerably louder for local hero Kemba Walker, the shooting star for the Charlotte Hornets who scored 60 points in a game earlier this season.

The crowd also showered old-timers Dwyane Wade and Dirk Nowitzki with affection, saluting the end of magnificent careers that included hard-fought playoff battles and championship runs. The two elder statesmen didn’t disappoint, connecting on 3-point shots that also energized the crowd.

While the All-Star game sometimes disappoints for the token defense that enables teams to score baskets at a breakneck pace, it does give serious players a chance to lower their defenses, enjoying the opportunity to smile and play a game with the other top performers in their sport.

Wade and Nowitzki, who each have infectious smiles, grinned on the court at their teammates, competitors and fans after they sank baskets.

A first-half highlight included a bounce pass alley-oop from North Carolina native Steph Curry to team captain Giannis Antetokounmpo. In the end, Team LeBron beat Team Giannis, 178-164.

The halftime show proved an enormous success, as rapper and North Carolina product — via Germany — J. Cole performed “ATM,” “No Role Modelz,” and “Love Yourz.” The young woman sitting near us knew every word of the songs, swaying, rocking and bouncing in her seat.

I asked her if she knew Cole would be performing and she said, “Of course.” I asked her whether she liked the basketball or the halftime show better. She said she enjoyed both.

Michael Jensen on a container ship in the Pacific Ocean, where he was measuring marine clouds. Photo from M. Jensen

By Daniel Dunaief

They often seem to arrive at the worst possible time, when someone has planned a picnic, a wedding or an important baseball game. In addition to turning the sky darker, convective clouds can bring heavy rains and lightning.

For scientists like Michael Jensen, a meteorologist at Brookhaven National Laboratory, these convective clouds present numerous mysteries, including one he hopes to help solve.

Aerosols, which come from natural sources like trees or from man-made contributors, like cars or energy plants, play an important role in cloud formation. The feedbacks that occur in a cloud system make it difficult to understand how changes in aerosol concentrations, sizes or composition impact the properties of the cloud.

“One of the big controversies in our field is how aerosols impact convection,” Jensen explained in an email. “A lot of people believe that when a storm ingests aerosols, it makes it stronger, because there are changes to precipitation and particles in the clouds.”

This process is called convective invigoration, which could make it rain more.

Another group of scientists, however, believes that the aerosols have a relatively small effect that is masked by other storm processes, such as vertical winds. 

Strong vertical motions that carry air, water and heat through the atmosphere are a signature of convective storms.

Jensen will lead an effort called Tracking Aerosol Convection Interactions Experiment, or TRACER, starting in April of 2021 in Houston that will measure the effect of these aerosols through a region where he expects to see hundreds of convective storm clouds in a year. 

From left, Donna Holdridge, from Argonne National Laboratory; Michael Jensen, kneeling; and Petteri Survo, from Vaisal Oyj in Helsinki, Finland during a campaign in Oklahoma to study convective storms. The team is testing new radiosondes, which are instruments sent on weather balloons. Photo from M. Jensen

The TRACER team, which includes domestic and international collaborators, will measure the clouds, precipitation, aerosol, lighting and atmospheric thermodynamics in considerable detail. The goal of the campaign is to develop a better understanding of the processes that drive convective cloud life cycle and convective-aerosol interactions.

Andrew Vogelmann, a technical co-manager of the Cloud Properties and Processes Group at BNL with Jensen, indicated in an email that the TRACER experiment is “generating a buzz within the community.” 

While other studies have looked at the impact of cities and other aerosol sources on rainfall, the TRACER experiment is different in the details it collects. In addition to collecting data on the total rainfall, researchers will track the storms in real time and will focus on strong updrafts in convection, which should provide specific information about the physics.

Jensen is exploring potential sites to collect data on the amount of water in a cloud, the size of the drops, the phase of the water and the shapes of the particles. He will use radar to provide information on the air velocities within the storm.

He hopes to monitor the differences in cloud characteristics under a variety of aerosol conditions, including those created by industrial, manufacturing and transportation activities.

Even a perfect storm, which starts in an area with few aerosols and travels directly through a region with many, couldn’t and wouldn’t create perfect data.

“In the real atmosphere, there are always complicating factors that make it difficult to isolate specific processes,” Jensen said. To determine the effect of aerosols, he is combining the observations with modeling studies.

Existing models struggle with the timing and strength of convective clouds.

Jensen performed a study in 2011 in Oklahoma that was focused on understanding convective processes, but that didn’t hone in on the aerosol-cloud interactions.

Vogelmann explained that Jensen is “well-respected within the community and is best known for his leadership” of this project, which was a “tremendous success.”

Since that study, measurement capabilities have improved, as has modeling, due to enhanced computing power. During the summer, Long Island has convective clouds that are similar to those Jensen expects to observe in Houston. Weather patterns from the Atlantic Ocean for Long Island and from the Gulf of Mexico for Houston enhance convective development.

“We experience sea breeze circulation,” Jensen said. Aerosols are also coming in from New York City, so many of the same physical processes in Houston occur on Long Island and in the New York area.

As the principal investigator, Jensen will travel to Houston for site selection. The instruments will collect data every day. During the summer, they will have an intensive operational period, where Jensen and other members of the TRACER team will forecast the convective conditions and choose the best days to add cloud tracking and extra observations.

Jensen expects the aerosol impact to be the greatest during the intermediate strength storms. 

The BNL meteorologist described his career as jumping back and forth between deep convective clouds and marine boundary layer clouds.

Jensen is a resident of Centerport and lives with his wife Jacqui a few blocks from where he grew up. Jacqui is a banker for American Community Bank in Commack. The couple has a 22-year-old son Mack, who is a substitute teacher at the Harborfields school district.

Jensen describes his family as “big music people,” adding that he plays euphonium in a few community band groups, including the North Shore Community Band of Longwood and the Riverhead Community Band.

As an undergraduate at SUNY Stony Brook, Jensen was broadly interested in science, including engineering. In flipping through a course catalog, he found a class on atmospheric science and thought he’d try it.

Taught by Robert Cess, who is now a professor emeritus at SBU, the class “hooked” him.

Jensen has been at BNL for almost 15 years. Over that time, he said the team has “more influence in the field,” as the cloud processing group has gone from six to 18 members. The researchers have “expanded our impact in the study of different cloud regimes and developed a wide network of collaborations and connections throughout the globe.”

As for his work in the TRACER study, Jensen hopes to “solve this ongoing debate, or at least provide new insights into the relative role of aerosols and dynamics.”

Stock photo

By Daniel Dunaief

Daniel Dunaief

We’ve all had moments when we wonder: Is this good enough?

The answer depends, in part, on the importance of the outcome. If we’re a cardiac surgeon and we have our hands inside the chest of someone who needs a new valve or stent, good enough doesn’t cut it. We need to make absolutely sure we’ve done everything we can because no one wants to open up someone’s chest a second time to correct a small error or to retrieve something we should have removed.

If we’re driving a car on a slippery road, a turn that’s good enough on a sunny day may not be sufficient in the rain or on ice. We may need to slow down enough that we don’t need to hit the brakes as we head into the turn.

Those are, of course, more extreme examples. Fortunately, most of us live in a world where what we do doesn’t seem so critical. We might be writing a paper about Shakespeare, filing legal briefs, collecting receipts for tax purposes or shoveling snow from our driveway. Each of those tasks, in and of themselves, may not seem to require our best because we have better things to do, we want to get through the class, or we’re tired and we need to give ourselves a rest.

Nonetheless, the smaller efforts can, and do, add up. When we’re shoveling snow, good enough might miss a slick patch of ice that our wife or best friend might slip on while they’re walking to the car. Going beyond good enough could prevent the discomfort or injury from falling.

Even an essay about Shakespeare may require us to think more deeply about what it means to be in love. Down the road, that might help when we’re considering ways to express our admiration or appreciation of a partner, giving us wisdom and words beyond our years. Great words boost the power of our sentiments, just as the sight of a whale breaching transforms a trip to the beach into a memorable outing.

Of course, operating at full strength or beyond good enough for everything may be so physically and mentally draining that we might spend too much time on activities we consider trivial, leaving us with fewer resources to tackle bigger challenges.

So, how do we determine the difference between an activity that requires us to be good enough and another responsibility that mandates something more?

For starters, we may not be capable of more than a few extraordinary efforts in a day. That may be a product of how much sleep we get, how much we can control in our day or how we feel, especially if we’re battling a head cold or some chronic condition.

Keeping ourselves healthy and making sure we have enough energy can and will give us the ability to vault us over the good-enough threshold.

Good enough can become a habit, just like so many other efforts. We can run a mile every other day or we can go a bit farther each time. We may find that good enough for others, or even for former versions of ourselves, is just a start. We may raise the bar for the expectations we set for ourselves to the point where good enough today is so much better than earlier efforts.

Routine or even mundane activities likely don’t require perfect performance. Doing them well, or even beyond “good enough,” keeps us sharp and focused for our more important tasks and also sets a good example for our children, who are watching and listening.

We can and will improve our lives when we decide to raise our own expectations for good enough.

From left, Anne Churchland and Tatiana Engel. Photo from CSHL

By Daniel Dunaief

Movies have often used an image of a devil on one shoulder, offering advice, and an angel on another, suggesting a completely different course of action. People, however, weigh numerous factors when making even the simplest of decisions.

The process the brain uses to make decisions involves excitatory and inhibitory neurons, which are spread throughout the brain. Technology has made it possible to study thousands of these important cells on an active mouse, showing areas that are active at the same time.

Anne Churchland, an associate professor at Cold Spring Harbor Laboratory, and Tatiana Engel, an assistant professor at the same facility, are collaborating on a three-year grant from the National Institutes of Health that will study the way neurons interact to understand the patterns that lead to decisions. 

Engel said she, Churchland and another collaborator on the project, Stanford University Professor Krishna Shenoy, applied for the funding in response to a call from the NIH to develop computational methods and models for analyzing large-scale neural activity recordings from the brain.

Churchland and Shenoy will provide experimental data for the computational models Engel’s lab will develop. The data is “huge and complex,” Engel said, and researchers need new methods to understand it. “The simple techniques don’t translate to large-scale recordings,” Engel said.

Churchland and Engel jointly hired James Roach, a postdoctoral researcher who recently earned his doctorate from the University of Michigan and works in both of their labs. 

Churchland’s lab will provide data from the mouse model, while Engel’s lab brings computational expertise.

“Little is known about how these neurons are connected to behavior,” Engel said. Their research will hope to explain the role of inhibitory cells, which may have a more finely tuned function beyond keeping cells from remaining in an excited state.

The prevailing view in the field is that inhibitory neurons provide a balancing input to the network to prevent it from generating too much excitation or creating a seizure. Inhibitors are like the regulators that tap the brakes on a network that’s becoming too active.

Excitatory neurons, by contrast, are the ones that have an important job, representing the decisions individuals make.

Churchland is going to measure neural activity using a 2-photon microscope that allows her to measure the activity of about 600 neurons simultaneously. 

“This provides an incredible opportunity to analyze the data, using tools borrowed from machine learning and dynamical systems,” she explained in an email.

What Churchland’s data has helped show, however, is that the inhibitory neurons are doing more than providing a global braking signal. “They have some dedicated role in the circuit and we don’t know what that role is yet,” Engel said.

The team will build neural circuit models to help understand how the system is wired and what role each type of cell plays in various behaviors.

“We are developing computational frameworks where we can go and analyze activities of large groups of cells and, from the data, determine how individual cells contribute to the activity of the population,” Engel said.

Brains have considerable plasticity, which means that when one area of the brain isn’t functioning for whatever reason — through an injury or a temporary blockage ‒ other areas can compensate. “The whole problem is immensely complicated to figure out what a brain area is doing normally,” she explained. The picture can “completely change when there’s brain damage.”

Research is moving in the direction of understanding and manipulating large neural circuits at once, rather than a single area at a time. 

“Models can extract general principles, which still hold true even in more complex” systems Engel said. The principles include understanding how excitatory and inhibitory cells are balanced. “Models can help you figure out what works and doesn’t work.”

Roach, the current postdoctoral researcher working with Engel and Churchland, will start with modeling and then will develop experiments to test the role of inhibitory cells. He has already worked on computer programs that interpret neurological circuits and laboratory results. He is also receiving laboratory training.

At this point, Engel and Churchland are working on basic science. Engel explained that this type of research is the foundation for translation work that will lead to an improved diagnosis and treatment of neurological disorders. Basic science can, and often does, provide insights and information that help those working to understand or treat disease, she suggested.

Churchland was pleased with her collaboration with Engel.

Engel is “best known for modeling work she did studying neural mechanisms of attention,” Churchland explained in an email. “She is a great addition to Cold Spring Harbor! We work together in the same building and are trying to unravel the mysteries of how large groups of neurons in the brain work together to make decisions.”

A resident of the facilities at Cold Spring Harbor Laboratory, Engel grew up in Vologda, which is over 300 miles north of Moscow. Starting in seventh grade, she attended physics and math schools, first in her home town and then at a boarding school at the Moscow State University.

She learned to appreciate the value of science from the journals her parents subscribed to, including one for children called Kvant magazine. She solved physics problems in that magazine. “I enjoyed the articles and problems in Kvant,” she explained in an email.

As for her work, Engel suggested that there were many discoveries ahead. “It is an exciting and transformative time in neuroscience,” she said.

By Daniel Dunaief

Daniel Dunaief

Ah, Cinderella. The glass slipper. The handsome prince. A story that even frustrated, annoyed, irritable teenagers can love, right?

That’s what we thought when we bought the tickets. My wife and I enjoy good music, lyrical singing and creative costumes. So we figured we’d share some of that with our teenage children before we pack them up and ship them off to the next chapter of their lives.

The outing started out with such promise. I drove my teenagers to meet my wife. We connected with her outside a garage, where she used her parking pass to get us into a building several blocks from the show.

As soon as she got in the car, she could tell the mood was dark and foreboding.

“What’s the matter?” she asked.

“Nothing,” Angry 1 and Angry 2 muttered in unison.

“Do you not want to see the show?”

No answer.

“Well? Would you rather go home? Dad can take you back.”

No answer.

“Can I please have my ticket?” my wife asked, sticking out her hand. “I will go alone.”

“No,” I replied. “I want to go, too.”

Walking through a city we didn’t know well, we raced to get to the theater before 7 p.m. It wasn’t easy, but we got in by 6:58 and race-walked to the door.

“You can’t come in,” the usher said.

We slumped our shoulders.

“But it’s not 7 p.m.,” my wife observed.

“Yes, but the show doesn’t start until 7:30. We’ll open the doors in a few minutes.”

Funny, right? Well, no, not in the moment.

“Wait, this starts at 7:30 p.m.?” my son asked. “How long is it?”

The usher informed us it was three 45-minute acts, with two 15-minute intermissions. That meant we’d get home around 11 p.m.

“I have so much homework,” he lamented.

We decided I would retrace our steps back to our car so he could get his backpack, order an Uber and send him on his way. I took a ticket and ran with him to the car. Fortunately, the Uber transfer went well. As I trotted back to the theater, I realized I was missing something. I called my wife.

“What’s the matter?” she asked, sensing the continuing unraveling of the evening.

“I can’t find the ticket. It must have fallen out of my pocket.”

“Oh no, how are you going to get in?”

We talked for a moment and then I realized we could show my wife’s two tickets to the usher with whom I spoke to on the way out. Our daughter could hover near the seats. Fortunately, the usher let me return.

Once the show began with frenzied music and considerable dancing, we waited. And waited. And waited. No one spoke. No one sang. It was, to the surprise of all three of us, a ballet.

Now, I know many fine people who love the ballet. Just as I know many wonderful, albeit misguided, people who love the Patriots. For the three of us, however, a ballet was not only unexpected, it was also unwelcome.

By the time intermission began, we were laughing.

“Should we stay for the second act?” my wife asked.

We stayed for another 45 minutes and left the theater.

“You know, it could have been worse,” our daughter said, as we were driving back home.

“Oh yeah, how?” my wife and I wondered, incredulous.

“All four of us could have seen it,” she said.

We chuckled as we hit every red light on the way home from the shattered glass slipper of an evening.

Daniel Dunaief

By Daniel Dunaief

The film “Bohemian Rhapsody” is far better than the critics suggest, while “Green Book” isn’t as deep or powerful as it could be. After watching four movies recently, including “Aquaman” and “Mary Poppins Returns,” I want to share my reactions to each of these films.

Featuring my favorite superhero, “Aquaman” had the opportunity to inspire and demoralize me at the same time. The movie was going to be a CGI (computer-generated imagery) extravaganza, with numerous impossible-to-imagine scenes filmed underwater. I don’t generally crave spectacular and splashy visuals, especially if they are designed to compensate for a weak script or disappointing acting.

Unfortunately for the water hero, the CGI was considerably more polished than the script, with attempts at humorous dialogue that were so underwhelming that it was tempting to urge the actors to stop talking and continue to swim through the scenery. Nonetheless, the movie did have its escapist and captivating elements. Perhaps the best way to enjoy a movie like this is not to think too much and to appreciate the ride. The spectacular visual spectacle almost merited the effort of seeing the movie on a large screen, instead of waiting for it to appear on a movie channel in a few months time.

Making a “Mary Poppins” sequel immediately asks the film to build on its successes, while introducing something new and engaging in its own right. The film succeeded on the first front, but fell a bit short, at least for me, on the second. Emily Blunt captured Mary’s supreme self-confidence, and magic magnificently. She took an iconic character owned by Julie Andrews and made it her own. The animated sequences, which were more lavish and extended than in the original, helped the movie create its own indelible images. The lyrics to the songs, however, weren’t quite as memorable as the original, at least for me.

“Green Book” maneuvers through the societal challenges that arise from a white driver who is transporting an African-American pianist, Don Shirley, through the South for performances in 1962. The movie feels important because it addresses bias and stereotypes during a period when the struggle for Civil Rights took root. Set against racial tensions, the film addresses the developing relationship between its two stars and has moments of tenderness and transformation for the duo at the heart of the story. It also addresses the remarkable contradiction between white society eager to enjoy the talents of an African-American entertainer and the inability of that same audience to respect the person as an equal.

Still, the movie felt like it could have been so much more. The film shows details of the life story of the driver Tony Lip, played with his usual energy and passion by Viggo Mortensen. Shirley, portrayed by Mahershala Ali, tells the background of his life. The movie would have benefited from a deeper and better understanding of Shirley’s life, which, some members of his family have suggested was different from the portrayal in the film.

That leads me to “Bohemian Rhapsody.” I didn’t know a great deal about the musicians or their backstory. For me, the film was an enormous hit for two reasons: Rami Malek, who played lead singer Freddie Mercury, and the music itself. Malek embodied the energy, spirit, and unique character that was Mercury, parading around the stage, commanding every scene and blending bravado with an underlying vulnerability. The story doesn’t turn Mercury into a saint but, rather, shares his complicated life.

For fans of Queen’s music, the movie is a satisfying compilation of familiar hits that allow the legend of a wildly successful group to resonate.