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Daniel Dunaief

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Ogochukwu Enekwizu with a suite of instruments at Brookhaven National Laboratory to make and study soot-seeded clouds. Photo courtesy of BNL

By Daniel Dunaief

Combining forces to form a three-part team, they strive to understand processes that are as visually stunning and inspirational as they are complex and elusive.

Clouds, which are so important to weather and climate, are challenging to understand and predict, as numerous processes affect properties at a range of scales.

A team from Brookhaven National Laboratory has provided the atmospheric sciences community with a host of information that advances an understanding of clouds.

In the atmospheric sciences community, “we typically talk about the three legs of a stool: modeling/ theory; field measurements; and targeted laboratory studies,” explained Arthur Sedlacek, Chemist in the Environmental and Climate Science Department.

Sedlacek conducts field experiments by collecting air samples from clouds in a range of locations such as flying through wildfire plumes.

In the beginning of 2021, BNL added postdoctoral researcher Ogochukwu Enekwizu to bolster another leg of that stool. Enekwizu conducts the kind of laboratory studies that provide important feedback and data for the work of Sedlacek and cloud modelers like Nicole Riemer, Professor in the Department of Atmospheric Sciences at the University of Illinois-Urbana Champaign.

Enekwizu studies how soot aerosols from wildfires influence the lifetime and formation of clouds. She’s also investigating how soot-cloud interactions affect the absorption and scattering of light by soot particles.

Wildfires provide kindling for the climate, as fires release warming agents that contribute to increases in global temperatures which result in more wildfires. By determining how these smaller scale processes in soot affect clouds, Enekwizu can reduce the so-called error bars or level of uncertainty in the models other scientists create and that rely on the data she develops.

Enekwizu’s collaborators appreciate her contribution. As a modeler, Riemer suggested that Enekwizu’s work provided key information.

“While the microscale processes of soot restructure are incredibly complicated, [Enekwizu] was able to boil it down to a few simple parameters,” Riemer explained. “This makes it feasible to implement this process in a model like ours, which look at aerosol populations, not just a few individual particles. From there, we can come up with ways to implement this knowledge into climate models, which are still much more simplified than the model that we are developing.”

Sedlacek, who is her supervisor, suggested that Enekwizu’s work is “now on the cusp of answering important questions of how aerosols interact with clouds.” He descried her set up as “truly unique” and expects her results to inform the community about wildfire aerosol-cloud interactions and will offer guidance on other necessary field measurements.

In broader research terms, wildfires can be important for the ecosystem, as they remove decaying material, clear out underbrush, release nutrients back into the soil and aid the germination of seedlings

The increasing frequency, duration and intensity of these fires has been important to the scientific community. The general public has become increasingly aware of its importance as well, Enekwizu said.

Collaborations

Recruited to BNL by Sedlacek and Atmospheric Scientist Ernie Lewis, Enekwizu is considering collaborations with other researchers at BNL.

She has started speaking with scientists at the Center for Functional Nanomaterials about exploring soot microstructure in a planned joint collaboration with her New Jersey Institute of Technology PhD advisor Dr. Alexie Khakizov. For this effort, Enekwizu has been in discussions with Dmitri Zakharov, who is in charge of the environmental transmission electron microscope at the CFN.

She hopes to take samples and introduces forces under a controlled environment in the transmission electron microscope to see how that affects the structure of soot in fine detail.

Looking at the news with one wildfire event after another, Enekwizu feels compelled to conduct research in the lab and share data amid “a heightened sense of urgency to get this work done” and to share it with the world at large.

Scientific origins

Born in the southeastern part of Nigeria in Enugu and raised in Enugu, Lagos and Abuja, Enekwizu developed an interest in science at 13. She enjoyed classes in a range of sciences and said chemistry was her favorite.

“I knew I was not going to go into medicine because I was squeamish,” she said.

Chemical engineering fascinated her and also appeared to offer career opportunities.

During a chemical engineering internship, she worked at the Nigerian National Petroleum Corporation where she learned about flaring practices. It inspired her final year project on biogas as a renewable energy source and sparked her curiosity on the fate of pollutants and particulate matter that arise from legal and illegal flaring activities. 

In flaring, companies burn off excess gas to control pressure variations, increasing the safety of the operation at the expense of burning a potential resource.

When Enekwizu was at NJIT, Lewis, who is a longtime collaborator with Sedlacek, reached out to Khakizov to inquire about someone with a background in carbonaceous aerosols. After interviewing with Lewis, Sedlacek and others, Enekwizu received the job offer and began working in January of 2021.

A resident of Ridge, Enekwizu, who goes by the name “Ogo,” enjoys festivals and events around Long Island. She also appreciates the area’s ubiquitous beaches and has delighted in strawberry picking.

She hopes to explore Montauk later this spring or summer.

Mentoring

Enekwizu is passionate about mentoring students, particularly those who might be under represented in the field of Science, Technology, Engineering and Medicine.

She served as a graduate student mentor for Divyjot Singh, who was an undergrad at NJIT. Enekwizu taught Singh, who had grown up in Bhopal, India and had only been in the United States for six months when they met, “how to come up with research questions, how to develop hypotheses, how to write a proposal, how to make good presentations for conferences and everything in between,” he explained in an email.

While working with her, Singh found his passion for research and decided to pursue a PhD. 

Enekwizu is also passionate about supporting young women in science. She suggested that young black girls sometimes feel intimidated by STEM classes and careers. She urges a hands on approach to teaching and hopes to be a role model.

“If young girls see people like me thrive in STEM, they’ll be encouraged not to give up,” she said. “That is a huge win, in my opinion.”

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METRO photo

By Daniel Dunaief

Daniel Dunaief

They’ll win some, they’ll lose some, and it’ll rain, and they’ll have to play some other day.

No, I’m not going to predict anything about the on field action this year as the “boys of summer” take the field this week for the start of the 2023 baseball season.

Instead, I’m going to make some predictions about the action in the stands. After all, the number of people and stories from the stands far exceeds the paltry size of the teams, umpires, grounds crew and everyone else involved with “The Show.” So, without further delay, here are a few predictions for the upcoming season.

Someone will walk into one of the local stadiums and be too awestruck to speak. He may have been to other games, but returning to his favorite stadium and looking at the shimmering green grass, the bright foul lines, and the oversized baseball bag will take his breath away, even if only for a moment and even if no one notices the goose flesh on his arms despite the warm temperature.

Someone will share some of their favorite lines from baseball movies, suggesting that the team is a “bunch of lollygaggers,” or that, in as deep a James Earl Jones voice as they can muster, “the one constant through all the years, Ray, has been baseball.”

During long day games, fans, clad in T-shirts, jerseys or tank tops, will forget sunscreen and will develop a sunburn. For some, that sunburn will be a reminder of the game. For others, it might provide sore or red skin.

Debates that border on arguments will occur in every part of the stadium. Some disagreements will arise over whether the umpire made the right call, while others will reach into history. Who was the best left fielder? Should Pete Rose be in the Hall of Fame?

Fans will celebrate birthdays, waiting for that fleeting moment when their name appears on the screen with best wishes from Joe, Mo, Mary and the rest of the crew.

People will propose marriage. Most will say “yes” and will cover their mouths in astonishment. Some will storm off, throw the ring back, or yell something, leaving others to wonder whether the scene was real or staged.

Some fans will offer unconditional support for their favorite players, urging them on even after they struck out four times. Others will reserve the right to suggest that they could do better or that the player is a “bum.”

Most fans will stand in salute to veterans, as the public address announcer shares details of a person’s service and awards, and his or her family beams nearby, blinking back tears in a strong sun.

Important people will take important calls, making it tough for them to focus on the game. Some of those people will have to leave the game and go back to the office, while others will talk through a document or deal amid a series of ongoing crises.

Awestruck people will realize their fantasy and will catch a foul ball. They will raise the ball as if it were a trophy, giving the strangers around them a chance to applaud. A generous fan will likely hand a ball over to a nearby child, knowing how valuable that souvenir will be for him or her.

Fans will high-five people sitting next to them during a key moment in a big game, sharing their joy with anyone and everyone.

Someone from an earlier generation will shout “Holy Cow” when a player hits a towering home run, sending his friends into fits of laughter.

Someone will believe that the next pitch will alter the course of the game and, perhaps, that person’s world, regardless of the score and the standings. Play Ball!

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Tim Malloy in Saudia Arabia in 1995.
Tim Malloy in Saudia Arabia in 1995.
Tim Malloy (right) with another jumper (Ness) from 2019 reenactment of Normandy.
Tim Malloy in a poppy field after Normandy jump.
Tim Malloy in Kuwait right after 9/11.
Tim Malloy fast-roping down to the roof of a building.
Tim Malloy skydiving off the coast of Long Island in the mid 1990's.

By Daniel Dunaief

Tim Malloy worked behind the scenes at highly visible military operations between 1976 and 2003. The fast twitch Malloy, who grew up in Islip and currently lives in Baiting Hollow, was frequently on high alert with his team of US Air Force Combat Pararescuemen.

Part of an elite group of soldiers with extensive and demanding training, Malloy, who retired as a Chief Master Sergeant, waited 15 miles away aboard a C-130 plane during Space Shuttle launches, prepared to jump into the water to provide assistance to astronauts in the event of an emergency.

In addition to heading into violent and dangerous storms, Malloy traveled to countries including Turkey, Kuwait, Saudi Arabia, and Iraq as part of the Air Force’s efforts to protect and retrieve troops.

Malloy and his fellow pararescuemen recognized the dangers of their job. “Every time you get in an airplane, you don’t know if it’s going to come back,” he said. “It’s a humbling feeling.”

A friend from childhood who Malloy convinced to become a pararescueman, David Ruvola suggested that Malloy is the kind of partner in arms other members of the military hope to find.

“When you’re dealing with life and death situations, you want the guy next to you that’s going to put his life on the line for yours,” Ruvola said. “You have to have the mindset of ‘if I lose my life trying to save my brother next to me, guess what, I’m going.’ There’s no question that [Malloy] is that kind of guy.”

Malloy and Ruvola were a part of a unit that supported efforts in Iraq.

During a firefight outside Abu Ghraib prison 20 years ago, a Humvee with several soldiers aboard rolled into a waterway. Without a moment’s hesitation, another soldier, Andrew Baddick, dove into the water to try to rescue the crew. Ruvola, who was a squadron commander during a time when Malloy was a pararescueman, were called to the scene.

The pararescue squad was the only one in the country with scuba tanks, although those tanks didn’t have any air. Ruvola filled them up in a firehouse and sent two helicopters, including Malloy to the scene.

Malloy and his team entered the dirty water, where they traveled hand over hand to find the fallen soldiers, including Baddick. “It took us quite a while, but we recovered the bodies,” Malloy said.

Emotional meeting

About a decade after recovering the soldiers, Malloy was at a camper show in Hershey Park, Pennsylvania, where about 50,000 people attended. He noticed a man wearing a gold star hat, which meant he had lost a family member during a conflict. Malloy expressed his sympathies. When the father told his story, Malloy recognized the details. “I recovered your son’s body,” Malloy told Joseph Baddick, who was Andrew’s father. “I remember the whole thing.”

At lunch that day, Malloy shared details with Baddick about his son. “He didn’t know the nuts and bolts of the whole thing,” Malloy said. “It was, by far, one of the most emotional moments for me in the military.”

Sea rescues

In addition to high profile missions or rescue attempts, Malloy experienced some challenging and high risk efforts that were part of his Air Force responsibilities.

After a Portuguese ship sank, four fisherman were in a life raft designed for three people. Malloy and another rescue man jumped from a helicopter and swam to the raft in frigid waters in the middle of November. Suffering from hypothermia, the fishermen weren’t thinking clearly and had started taking off their clothing.

The Air Force crew raised the fisherman, who had pink skin from the cold, into the helicopter. One of Malloy’s crew got into a sleeping bag with a fisherman to help raise his body heat. In the cold helicopter, the crew administered intravenous fluids they had preheated.

“As the blood was getting back into their body, they started shivering violently,” Malloy said, which was a good sign that they were starting to warm up.

In a separate incident, the appendix of a man aboard a tanker in the middle of the ocean burst. Malloy and another rescuer jumped out of a C-130 in the middle of the night and swam to the ship, where they relied on their training as emergency medical technician at a paramedic level to treat the crew member.

A life changing article

When he was young, Malloy recalled how people stood when the flag went by during Flag Day and Veteran’s Day. He enjoyed the hot dogs and soda he consumed at the American Legion after attending parades.

After he graduated from Islip High School, Malloy wasn’t sure what he’d do with his life. “I ended up reading an article in the Daily News about guys who jumped out of planes and rescued people,” he said. “I mentioned in to my mom and she said, ‘it sounds like it’s right up your alley.’”

The training was more difficult than he thought, especially because, despite being playing lacrosse, basketball and football, he wasn’t much of a swimmer. Even with the Air Force’s effort to weed out people, he didn’t believe quitting was an option.

Sounding like Richard Gere in the movie An Officer and a Gentleman, Malloy said he had “nothing to go back to.” Being surrounded by like-minded men raised Malloy’s game, making him work harder. 

His military experience “fit my personality and lifestyle and worked for me,” Malloy said. He joined the Suffolk County Police Department after he retired, where he worked until 2018. The military “taught me how to treat people,” he said. Even some of the people he arrested thanked him for how he interacted with them.

Normandy

After he retired from the police force, Malloy heard about an effort to recreate the 75th anniversary of the Allied Forces’ attack at Normandy. He signed up to jump out of an airplane. The participants had to have 15 recent jumps to qualify, which he did by jumping out of planes in Oklahoma, Florida and Texas. Wearing original combat uniforms and jumping out of a restored airplane from the invasion, Malloy, who was the only New Yorker in the anniversary jump, was on the first plane from which soldiers parachuted into a poppy field in France. French residents came up to him and thanked him for coming.

In the United States, Malloy appreciates the treatment veterans receive from most civilians.“It’s a really good feeling,” he said. “I get treated with a lot of respect.”

This column is generously sponsored by Casper Contracting Inc.
631-605-5129/631-846-1537/caspercontractinginc.com

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Second from left, Brookhaven Town Supervisor Ed Romaine and County Executive Steve Bellone announced a Community Host Agreement with Sunrise Wind. Photo from Suffolk County

On the first day of spring, with cool breezes and a propeller plane flying overhead at Smith Point County Park, Suffolk County officials celebrated a Host Community Agreement with Sunrise Wind, an energy project that will use windmills to provide power to about 600,000 homes.

The offshore wind project, which will be developed 30 miles east of Montauk, marks the second such effort to use renewable energy as a power source. South Fork Wind is currently under construction and will provide energy by the end of the year.

“We are going to have not just jobs; we are going to have careers for people here on Long Island for years and decades to come.”

— Steve Bellone

The Sunrise Wind farm, which Denmark-based Ørsted and east-coast-based Eversource is leading, will make landfall at Smith Point County Park on the South Shore. The lines would feed under the Smith Point Bridge and under William Floyd Parkway.

The effort is a part of New York State’s goal of increasing the use of renewable energy to 70% by 2030 and to 100% by 2040, lowering the state’s carbon footprint and slowing the effect of greenhouse gases on global warming.

In addition to celebrating the environmental benefits of the agreement, officials stood with labor leaders to recognize the job and economic benefits.

“We know that this clean energy future is also about job creation and creating new industries that will put people to work,” County Executive Steve Bellone (D) said at a press conference announcing the agreement. “We are going to have not just jobs; we are going to have careers for people here on Long Island for years and decades to come.”

The effort will include 100 jobs in an operations and maintenance hub in East Setauket.

Sunrise Wind agreed to pay $170 million over 25 years. Brookhaven will get over $5 million from the project each year, starting in 2025 for the next quarter of a century.

“Clean air and clean water are non-partisan issues. This is a promise we need to keep for our communities.”

— Julie Tighe

The announcement of the agreement came on the same day that the United Nations Intergovernmental Panel on Climate Change warned that the world would likely pass a dangerous temperature increase within the next decade, driving global warming to deadly levels unless countries cut back on fossil fuels.

Such an unchecked temperature increase could lead to famine, disease, an increase in violent storms, and a reduction in farmable or habitable land.

The UN report urged nations to cut the use of coal, oil and gas, which contribute to the majority of the emission of greenhouse gases like carbon dioxide.

Recognizing the overlap between the UN report and the announcement about the Host Community Agreement in the county, Adrienne Esposito, executive director of Citizens Campaign for the Environment, suggested that the county was doing its part.

The UN “declared that we need to make sustainable, meaningful changes in this decade,” Esposito said during the press conference. “That’s exactly what Suffolk County and the state of New York are doing. We have the low carbon tools to live in a world with lower emissions and now we must use them.”

Changing the way the county produces energy “changes the world” and the “future for the better,” Esposito added.

Julie Tighe, president of the New York League of Conservation Voters, applauded the practical and forward-looking element of a concrete plan that includes the start of construction later in 2023.

“Unless we turn these commitments into projects on the ground, it’s just a piece of paper,” Tighe said. This agreement is “one step closer to reality.”

Tighe congratulated political leaders from both parties, including Bellone and Brookhaven Town Supervisor Ed Romaine (R) for coming together on this environmentally, ecologically and economically favorable project.

“Clean air and clean water are non-partisan issues,” Tighe said. “This is a promise we need to keep for our communities.”

The wind farm plan will also include courses at Stony Brook University and SUNY Farmingdale, as well as a National Offshore Wind Training Center in Brentwood. The center will expand access to job opportunities and educational advancement, particularly for high school and college-age New Yorkers entering the job market.

The training center includes a 22-year license agreement with Suffolk County.

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From left, Isabella Colombo, Konstantine Rountos, and Mackenzie Minder with their research paper. Photo from Konstantine Rountos

By Daniel Dunaief

Good news for shellfish eaters on Long Island.

According to a baseline study conducted by recent St. Joseph’s University graduates in the lab of Associate Professor Konstantine Rountos, oysters and hard clams have less microplastics than they do in other areas in the United States and the world.

Caused by the breakdown of larger plastic pieces, pellets used in plastics manufacturing and from micro beads that can be a part of cosmetics, microplastics are found throughout the world and can float around waterways for extended periods of time.

Konstantine Rountos

Filter feeders like clams and oysters, which play a key environmental role in cleaning local water, could accumulate microplastics. Researchers don’t yet know the potential harm to humans from consuming shellfish with microplastics.

“I was optimistic that the concentrations are lower than with shellfish in other countries and definitely in other areas of the United States, so that’s a positive for Long Island shellfish growers,” Rountos said. “It’s good for seafood lovers, too.”

To be sure, Rountos cautioned that more research was necessary to explore the concentrations of smaller microplastics to provide a more complete understanding of the accumulation of these particles. Nonetheless, he described this step in the study as “positive.”

In other areas of the country, previous studies revealed a higher concentration of microplastics in local shellfish. In the lower Chesapeake Bay, researchers found concentrations of 5.6 to 7 microplastics per gram of soft tissue in eastern oysters, while other scientists found concentrations of 0.56 to 2.02 microplastics per gram in soft tissue in oysters and 0.38 to 1.99 microplastics per gram of soft tissue weight in hard clams.

By contrast, Rountos, Mackenzie Minder, who is the first author on the paper, and Isabella Colombo discovered in their study of 48 oysters at four sites on Long Island was 1,000 times lower with eastern oysters. They also discovered no microplastics in hard clams at two sites around the island.

The lower numbers on Long Island may also be a product of the sieve size Rountos and his students used, which may not have captured smaller particles.

In a paper published in Marine Pollution Bulletin, Mackenzie, Colombo and Rountos suggested that one potential explanation for the difference in microplastics concentrations could arise from the potentially lower levels of microplastics in the surrounding water.

Other proposed studies are exploring the concentration of microplastics in local waterways.

Gordon Taylor, Professor and Division Head in Marine Sciences and Director of the NAno-Raman Molecular Imaging Laboratory, has two grant applications pending to sample Long Island waters, including the Long Island Sound, Peconics, Great South Bay and the New York Bight. His plan is to sample true microplastics in the water, through beach surveys and microplastics eaten by zooplankton.

Taylor will combine these observations with physical oceanography to model where these particles originate and where they are going.

Bringing research to the classroom

From left, Isabella Colombo and Mackenzie Minder with their research paper.
Photo from Konstantine Rountos

For Minder and Colombo, both of whom are now teaching on Long Island, publishing their work offered a welcome and exciting conclusion to their college studies, while also giving them ways to inspire their students.

“This allows me to bring real life experience [in research] into the classroom,” said Minder. “It’s important to me to connect to children certain concepts of what they see in everyday life. Pollution could potentially impact our waterways to the point where it could be getting into our food supplies and could affect us physically and mentally.”

Minder said the study “opened my eyes to see how subconsciously we are putting plastics in the environment” through activities like washing synthetic fibers.

A fleece with synthetic fibers has “plastics that you wash and those fibers end up in the water,” Rountos said.

Some cosmetics such as exfoliators used to have microspheres that ended up in the water. Many cosmetic companies are now using bits of coconuts for grittiness.

Undergrad power

Rountos appreciated the reaction from Minder and Colombo, who earned degrees in adolescent biology education, when he suggested they could publish their research. He said his two former students “dove in head first” and the three had regular meetings to draft the manuscript and address reviewer’s revisions and recommendations.

Minder and Colombo are pleased with the paper “It’s shell shocking,” Minder said. 

A resident of Hauppauge, Minder, whose hobbies include crocheting and reading, appreciates how her family has been showing copies of the paper to their friends and enjoys seeing the paper on refrigerators in her parents’ and grandmother’s homes.

A resident of Sayville, Colombo is serving as a building substitute for students who are 10 to 14 years old.

The research experience taught Colombo the value of communication, dedication and responsibility, which she has brought to the classroom. When she tells high school students about the publication, her students ask for signed copies of the paper.

“It’s such an honor and a privilege to be a part” of such a research effort, Colombo said.

Colombo’s family, who is proud of her for her work, is also relieved that she didn’t find the kind of contamination that might cause anxiety about the seafood they eat.

“Considering how many times I eat it for the holidays I was very concerned” about what they’d find, Colombo said.

Despite the trace amount of microplastics, Colombo and her family will continue to eat shellfish. She plans to hang the framed copy of the paper Rountos gave her in a future classroom.

Colombo decided to go into teaching after taking a living environment class with Sayville educator Cindy Giannico. She is grateful to Giannico for captivating “my desire to learn more and appreciate how applicable science is to your everyday life.”

Colombo has since come full circle and has been a student teacher in Giannico’s class. Giannico was thrilled to welcome Colombo, whom she recalled as “hard working” and “helpful” with other students even as a tenth grader, back to the classroom.

Colombo has since taken a job as a science teacher on Long Island. Giannico believes Colombo has forged a strong connection with her students through her caring and consideration and her willingness to work with them.

“Most people feel comfortable around her,” Giannico said. “She’s really mature.”

Colombo’s published work has sparked student interest in conducting their own research studies.

Rountos is proud of Minder and Colombo’s contribution. He described Colombo and Minder as “rare gem” students.

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A scene from 'No Time to Die'

By Daniel Dunaief

Daniel Dunaief

Infinitives appear to be like peanut butter and jelly for me. I don’t want to add bananas, nuts or anything else between the two spreads, because peanut butter and jelly represent a taste combination that agrees with me and my digestive tract.

The combination of the word “to” and a verb belong together, without adverbs, adjectives, nouns or other parts of speech jammed between them. I want to love, to live, to eat, to sleep, to play and to laugh without any additional words attempting to clog up the ideas or to interfere with the narrative flow.

And yet, in modern prose, people increasingly chose to split infinitives, jamming words in between “to” and a verb. For me, that’s like forcing a reader to add a verbal hiccup. Maybe some English — or language arts in modern educational parlance — teacher back in my days at Ward Melville High School shared his or her dislike for split infinitives that makes me want to cringe when reading an otherwise effective sentence.

To make my point, I’d like to consider (yes, this is a column about infinitives so prepare to be amazed) how several important quotes, phrases, book and movie titles might read with a split infinitive. To begin, let’s explore Thomas Jefferson’s words from the Declaration of Independence: “We hold these truths to be self evident.” Those words would falter if he had chosen to write: “We hold these truths to fundamentally be self evident.” 

Would you like to consider Shakespeare? Hamlet’s soliloquy in which he ponders whether “to be or not to be” would fall flat if he said, “to kind of be or not to comfortably be.” That not only sounds wrong, but it loses the power of a pithy line about the nature of existence and his willingness to continue to live (yup, two in a row) in a world of treachery.

Let’s pause to consider Harper Lee’s “To Kill a Mockingbird.” Perhaps an infinitive splitter might want to add an adverb, such as “To Treacherously Kill a Mockingbird” or “To Slanderously Kill a Mockingbird.” Both options struggle to add an unnecessary word.

How about James Bond’s “License to Kill?” Would a split infinitive change that to “License to violently kill?” It’s already a Bond film, so you’re prepared to witness violence. Would you prefer to imagine “License to vengefully kill?” Would that have affected its ability to win at the box office? I tend to doubt that.

Another Bond movie with an infinitive is “No time to die.” An adverb addict might want to convert the title to “No time to literally die.” Well, yeah, Bond films force the titular character to confront death. These days, people are inclined to overuse the word “literally” anyway, as in, “I literally ate all the food on my plate.” I suspect few people would interrupt to ask if you’d figuratively or literally eaten everything.

How about Tina Turner’s song “What’s love got to do with it?” If we split the infinitive, she might sing, “what’s love go to accurately do with it?” Turner doesn’t want to encourage love when she’s enjoying the physical connection. Would “accurately” threaten to trample on the song’s meaning?

The book by Ernest Hemingway, who preferred to use simple prose, would lose some of its resonance if we added anything to the title, “To have and have not.” Borrowing from a vastly overused word that could become “To fully have and have not.”

So, to sum up the idea, to get to the point, to address the important issue, and to make myself clear, I still believe, no matter how acceptable it might be, that splitting infinitives jams an unnecessary word where it doesn’t belong, threatening to dilute its meaning, to alter its trajectory and to cause unnecessary misdirection. Let’s agree to keep infinitives together, giving them room to be, to love and to bask in their original meaning. Now, to return to where I began, I’d like to find some peanut butter and jelly. 

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Nivea Pereira de Sa Photo by Rodrigo Carvalho da Silva

By Daniel Dunaief

When people are immunocompromised, exposure to what might ordinarily be a harmless fungus can cause significant health problems.

Researchers in the laboratory of Maurizio del Poeta, Distinguished Professor in the Department of Microbiology and Immunology at the Renaissance School of Medicine at Stony Brook University, have been looking to create new treatments and develop vaccines against these fungi.

Working with a team of scientists at Stony Brook, research scientist Nivea Pereira de Sa, who joined del Poeta’s lab in 2018 as a postdoctoral researcher, recently published research in the journal mBio about potential anti-fungal drugs that target a key enzyme in the fungus Aspergillus fumigatus. 

Without the enzyme, the fungus can’t cause disease and the host defenses have time to eliminate it even if the host is immunodeficient.

Working with Michael Airola, Assistant Professor in the Department of Biochemistry and Cell Biology at SBU, Pereira de Sa started out by trying to find the structure of sterylglucosidase, an enzyme that is a molecular key for the fungus during infection and that aids in its ability to adapt to environmental changes such as low oxygen levels and changes in pH.

Pereira de Sa learned how to do x-ray crystallography from Airola, a process that reveals the structure of compounds.

In an email, Airola described Pereira de Sa as an “expert” in the technique.

Airola called the research “one of the most exciting projects” he’s worked on and hopes the group can translate the results into the clinic. A talented biochemist, Pereira de Sa is also an “expert in so many different scientific areas,” Airola wrote, which he described as “rare.”

Pereira de Sa also determined the structure of the same enzyme for Cryptococcus, another invasive and potentially harmful fungus. The enzymes in both fungi have a high degree of similarity.

Pereira de Sa expressed satisfaction at the application of such work. “Every time I get a crystal structure, it’s so amazing,” she said. “I love doing that.”

Pereira de Sa started screening potential compounds to inhibit sterylglucosidase in Aspergillus,

Del Poeta’s lab coordinated the design and testing of these inhibitors with Iwao Ojima, Distinguished Professor in the Department of Chemistry and Director of the Institute of Chemical Biology and Drug Discovery at Stony Brook.

Refining potential drugs

Ojima’s group is synthesizing derivatives of the hits Pereira de Sa found and she will start tests outside a living organism, or in vitro, soon.

Ojima has synthesized several compounds using computer-assisted drug design. He is currently developing several inhibitors that scored high on his computational molecular docking analysis and will synthesize two to three dozen potential small molecules.

Ojima, who partnered with Pereira de Sa in this study, “greatly appreciates her and her seminal contributions to this project,” he wrote in an email. She made critical contributions to the study that ensured its success and Stony Brook is “very fortunate to have her as a leader in this project.”

Ojima plans to identify highly potent inhibitors individually for Aspergillus and Cryptococcus separately, and then will try to find and develop broad spectrum inhibitors based on those compounds.

The need for a treatment has increased dramatically as the number of immunocompromised patients has increased.

Invasive aspergillosis can have mortality rates above 90 percent. The World Health Organization last October released its first ever list of health threatening fungi, which includes Aspergillus.

Pereira de Sa suggested two possible uses for this inhibitor. It could work as a treatment, knocking down the virulence of the fungus or it could contribute to the development of a vaccine.

In strains with a mutated enzyme, a mouse model has full protection against infection.

Getting a vaccine approved through the Food and Drug Administration for immunocompromised individuals might be challenging, she said. Several studies would be needed to confirm its safety.

Del Poeta added that the vaccine his lab has developed is effective alone when heat killed, reducing the threat a live virus with a defective enzyme might pose to an immunocompromised patient. Del Poeta has been developing a vaccine for cryptococcus and aspergillus and is testing it for other fungal infections as well.

‘A beautiful cause’

Del Poeta described Pereira de Sa as a key contributor to his lab, who is methodical, systematic and hard working.

The program she is developing will take years to go to clinical trials, he added.

Del Poeta met Pereira de Sa in 2017, when he visited Brazil and spoke with her mentor, Daniel de Assis Santos, who gave her an enthusiastic reference.

After meeting with her for only five minutes, del Poeta offered her a job.

“I will never forget her face: surprised, joyful, excited and she could not hold back some tears,” del Poeta described.

Del Poeta is thrilled with his choice, as she has gone above and beyond his expectations.

Born and raised in Belo Horizonte, Brazil, Pereira de Sa lives in East Setauket with her husband Rodrigo Carvalho da Silva, who is an airplane mechanic.

She enjoys Long Island, particularly during the summer, when she goes hiking, visits parks, kayaks and goes paddle boarding.

Pereira de Sa is encouraged by the progress in her work and is hoping her research contributes to future treatments.

“We are developing tools to help people,” she said. “It’s a beautiful cause I’m fighting for.”

She said the mortality rate from these fungal infections is “very high,” especially because a fungus like Aspergillus is ubiquitous.

“The fungus is present everywhere,” she said. “We are inhaling the spores of it every day.”

The invasive fungal disease starts in the lungs and spreads to the rest of the body, including in the brain, which can cause seizures.

Pereira de Sa recognizes the urgency of developing an effective treatment.

“We need some solutions and we need it now,” she said. “We are not prepared to fight fungal infections” on a large scale.

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METRO photo

By Daniel Dunaief

Daniel Dunaief

Generally, we don’t need distractions. We’re distracted enough, what with our electronic devices allowing us to check the weather in Albany during a storm, the latest trends on social media, the minute-to-minute value of our investments, and the world of sports news and scores.

And yet, there are those times when we desperately need a distraction. Our boss, for example, might ask about a project for which we’ve done almost no work and that we promised to work on last week, but that we didn’t get to because we were, well, distracted by other things.

Everyone likely has their own bag of go-to distractions that they turn to in moments when they need to deflect or distract someone just long enough for a meeting to end, a temper tantrum to subside, or an anxiety to abate.

I often start with almost factual information. By getting a sensational and exciting story almost correct, I trigger people to check their own phones to see if they can prove me wrong about some detail that isn’t as important as recognizing some bigger problem, like not getting an assignment done.

This phone check also tends to pull people’s minds into their electronic devices, where they might see text messages that need attention, a picture of their dog that reminds them of an upcoming trip to the vet, or some other big news that will divert their attention away from my almost factual statement and whatever other subject I’m trying to avoid.

Then, there’s always passion. I’m a generally level-headed person who stays calm, even when discussing subjects that are near and dear to me. Dialing up the passion, like changing the decibel level in a soft song with a message, can be distracting and effective. “I can’t believe the spectacular sportsmanship that women’s softball team displayed when they carried the player from the other team around the infield so she could touch all the bases after she fell. I’m so inspired.”

That, of course, also encourages people to dive back into their phones. Most of the time, that is effective unless the phone reminds them of whatever I’m trying to avoid, in which case, I turn to other methods.

Reverently appreciating silence is also an effective method. It’s the slow-down-so-we-can-think moment. Staring off into the distance, putting up a finger as if I’m coming up with some great idea, and then thanking that person for giving me that time can often alter the trajectory of a meeting.

Once the silence ends, I slowly offer an awed appreciation for the value of time and space, an admiration for nature, or anything else that suggests a depth that counterbalances my ineffective presentation.

Poignant anecdotes or even effective and dramatic metaphors, if given the opportunity to share them, can also suggest that I’m capable of deep thoughts, even if I haven’t had any related to the incomplete assignment.

Then, of course, there’s the Socratic method. Someone asks me something about an assignment, and I lean into it, asking a wide range of questions about the assignment, its direction, our target audience, and opportunities to build on it.

The answers to those questions sometimes reveal more about the expectations.

I never pretend to have a stomachache. I know people do that, but I get stomachaches often enough that I wouldn’t even pretend to have one, lest my system decided to oblige me and turn my charade into an afternoon of discomfort.

In a pinch, I metaphorically beat up on myself, suggesting how I could have done better on this and that I am disappointed in the pace at which I’m completing this project. It’s hard to beat up on someone who has already accepted responsibility and is eager to make amends.

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Victoria Greening at the Grotte Mandrin site in France. Photo by Svenya Drees

By Daniel Dunaief

Last summer, the Anthropology Department at Stony Brook University brought 13 students to the south of France to help gather information from a rich archaeological site called the Grotte Mandrin.

Asa Wong-Gómez at the Grotte Mandrin site in France. Photo by Nicholas Gonzalez

The trip with the Field School through SBU Study Abroad enabled the students to work in the field and gather information from a site that has provided a treasure trove of information about Neanderthals and Homo sapiens from 54,000 years ago.

The students found the trip successful, inspirational and, at times, exhausting.

“I did archeology all summer,” said Asa Wong-Gómez, a senior anthropology major at Stony Brook, who spent time in Kenya before joining the team in France. “It was really cool.”

Wong-Gómez recalled the thrill of finding teeth and stones in the dirt. “The first day, everyone’s first find was super exciting,” he said.

The field expedition, which was the first Stony Brook ran at this site, enabled students to forge connections with each other and with the site’s leaders, including Stony Brook Lecturer Jason Lewis, Ludovic Slimak, cultural anthropologist at the University of Toulouse-Jean Jaurès, and Laure Metz, an archaeologist at Aix-Marseille University.

Victoria Greening at the Zooarcheological Training and Research Laboratory. Photo by Nicholas Gonzalez

“Working with everyone so closely for that month definitely builds really strong connections that have lasted since,” said Victoria Greening, who graduated from Stony Brook in the winter and is planning to start a Master’s program in the fall at the University of Oxford.

She appreciated the opportunity to be a part of new discoveries.

“Working with something that’s not in the written records and discovering it yourself was a privileged feeling,” said Greening, who grew up in Yaphank.

A happy grown up

Echoing Gollum from the “Lord of the Rings” series, Slimak would look at something a student found and say, “my precious, this goes in a special bag,” Wong-Gómez recalled.

Slimak reflected the joy he took in discovering compelling finds. “It was amusing, watching a grown adult be so happy,” Wong-Gomez said.

Eva Marsh, who is a senior at Stony Brook in the anthropology department, appreciated the excitement of finding flint. A couple of students, she recalled, also found teeth, including a horse’s tooth. The group discovered a massive core, from which early Homo sapiens would chip off pieces to construct arrows they would shoot from a bow to bring down buffalo or horses.

On the first night gathering at their summer accommodations, Marsh said the group looked up at a star-filled sky.

“There was not a lot of pollution there” or other lights, which was “really amazing,” Marsh said.

Marsh was nervous on her first day, as she didn’t know what to expect. The team played games for the first few nights and discussed why they all signed up for the field experience. Each night at dinner, they discussed the events of the day, Marsh recalled.

Svenya Drees at the Grotte Mandrin site. Photo by Victoria Greening

For Svenya Drees, who grew up in Port Jefferson and is a Master’s Student in Lewis’s lab, the experience was familiar, as she had conducted field work during the summer of 2021. “I knew what to expect,” she said. Still, she found the discovery of pebbles from a distant river intriguing.

“There’s this whole mystery at the site about pebbles that made it into the assemblage,” Drees said. “These rocks were brought there from the local river. I thought that was pretty awesome.”

The theory about the pebbles is that Neanderthals or Homo sapiens, who had lived in the cave at different times, deployed the pebbles to help remove flakes from the rock cores these ancient ancestors used to create weapons.

Some challenges

While the students enjoyed the experience, with many of them planning to continue in their anthropological studies, the summer included some challenges.

The students stayed in a house at the top of a hill. At the same time, the cave was also on a hill. Each morning, they walked down the hill to a car that drove them to the bottom of the Grotte Mandrin site, where they walked about 15 minutes up to the field station. At the end of the day, they had to climb back up to their temporary home.

“After digging holes all day, walking up the hill was not my favorite part,” Wong-Gómez said. Greening suggested that future participants in the program, which will also run this summer, bring sturdy shoes.

The students also sometimes carried heavy containers filled with sand. The physical challenges notwithstanding, most of the students eagerly anticipate future such explorations.

“It’s definitely the right field for me,” said Greening. “Working at Mandrin solidified that for me.”

Wong-Gómez hopes to continue his field work at the University of Florida. The university has accepted him as a PhD student, although he is awaiting word on whether he gets funding.

“When I got the email that I was accepted, it didn’t feel real,” Wong-Gómez said. “I really want to do this.”

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A reconstruction by Ludovic Slimak of the arrows Homo sapiens likely used 54,000 years ago in France. Credit: Ludovic Slimak

By Daniel Dunaief

Have bow and arrow, will travel, even in Eurasia 54,000 years ago.

An archaeological site in the south of France that’s 70 miles from the coastline called Grotte Mandrin not only provided evidence that Homo sapiens and Neanderthals lived in this area around the same time, but also offered proof that early humans used bow and arrows to hunt for prey like bison and wild horses.

Jason Lewis. Photo from SBU

In research published in the journal Science Advances, Jason Lewis, a Lecturer in the Department of Anthropology at Stony Brook University; Ludovic Slimak, cultural anthropologist at the University of Toulouse-Jean Jaurès; and Laure Metz, an archaeologist at Aix-Marseille University, shared an extensive analysis of stone artifacts that demonstrated the use of bows and arrows.

These hunting tools, which inhabitants of the cave could use to pursue herd animals migrating between the Mediterranean region and the plains of Northern Europe, provide the earliest evidence of mechanically propelled projectile technology from Eurasia.

“We looked for diagnostic evidence of a very powerful impact once the stone tip hits something,” said Lewis. “We can see experimentally what type of damage” is produced on the tips of the arrows. The damage to these arrows is in line with everything that modern archers are doing because the tools human ancestors used were so light, Lewis added.

The collaborative effort to study these arrows in labs across two continents involved an extensive analysis of the flaking pattern around the tips of the arrows. The researchers didn’t find any of the organic materials that the early hunters would have used to create the bow.

This technology, which likely took about an hour to make, likely enabled Homo sapiens to bring down prey. Effective hunting from about 10 to 20 yards likely would have required more than one arrow, particularly with the size and strength of the targets.

At an archaeological site in the Middle East, scientists described stone tools around the same time that look similar to the bows and arrows humans in Eurasia used.

“The evolving modern humans were developing and using projectile technology,” Lewis said.  

Cultural differences

Lewis, Slimak and Metz showed in a seminal paper last year that Homo sapiens and Neanderthals had lived in the same cave, sometimes separated by a year or even a season.

While these two types of humans lived around the same time and in the same place, they didn’t share the same technology or have the type of cultural exchange that would enable Neanderthals, who typically hunted with hand-thrown spears, to use the same hunting tools.

“There’s no evidence of learning exchange,” Lewis said. Neanderthals did not start using the smaller points typical of the arrows or that would have been used as projectiles.

“It doesn’t look like there was a cultural exchange between the two groups,” Lewis said, as the artifacts from the time Neanderthals occupied the cave didn’t include any arrows.

Cultures sometimes develop identities that preclude using technology from other groups. Such cultural differences existed in the Maale and neighboring Tsamai people in Southwestern Ethiopia.

“Even though [bows and arrows] might be logically or objectively advantageous, some cultures suggest that ‘that’s not what we do,’” Lewis said.

Indeed, cultural differences have occurred in other areas that groups haven’t bridged, despite the availability of similar resources and the chance to learn the technology.

At the cave in Grotte Mandrin, researchers found a large collection of stone tools in Layer E of the cave.

The scientists believe the numerous arrows could have been the early equivalent of a munitions dump.

While bows and arrows would have provided a hunting advantage to Homo sapiens, the technology doesn’t explain why the two groups of early humans occupied the cave or dominated the area at different times.

“I doubt it comes down strictly to stone tool technology,” Lewis said. “There’s not a continuous march of occupation and expansion” as the interactions between the two populations were long lasting and complex.

Homo sapiens and Neanderthals moved up into a region and then moved back. This is akin to the way European settlers interacted with Native Americans when ships first crossed the Atlantic.

The Europeans moved into the region, interacted with people who already in the country, returned home, and then, at a later point crossed the ocean again.

Arrow studies

To understand the technology used to create these arrows, Metz and Slimak have spent years studying the way rocks flake off or get damaged in response to contact with animals or objects they hit when shot through the air.

Working for over a decade, Metz has been conducting experimental replication of the effect of use on these stone tools.

Scientists who shoot these stone arrows into carcasses from butcher shops can see the flaking pattern and scratches on the arrows.

Lewis explained that the flaking on the arrow heads could not have been made during the creation of the arrows themselves.

“Only high velocity strikes” could produce such markings, Lewis said.

These kinds of studies combine geology, physics and natural science. Lewis said John Shea, Anthropology Professor in the College of Arts and Sciences at Stony Brook University, has pioneered the study of such technology during the Pleistocene Ice Ages.

Lewis explained that his primary role is to bring the contextual understanding about how various types of early humans were using the landscape and interacting with the animals.

He also brings the context of work he does in Africa around the same time period as a comparator.

Lewis explained that more research would be forthcoming from this site.

“This is part of a larger modern human ability to conceptualize the world,” Lewis said. Early humans were trying to change their environment to match their needs, with boats, clothing, dwelling structures and other elements of their lives.

Such tool use could reduce hunting time and could enable a greater division of labor, suggesting that “each person didn’t have to do everything” to meet basic needs. 

 

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