CLOSE
Authors Posts by Daniel Dunaief

Daniel Dunaief

1466 POSTS 0 COMMENTS

by -
0 594
Dr. Monika Woroniecka, a physician at Stony Brook Children’s Hospital. Photo courtesy Stony Brook Medicine

By Daniel Dunaief

Dr. Monika Woroniecka, a physician at Stony Brook Children’s Hospital, died on Saturday during a trip with her family to see the eclipse near the Canadian border when she fell out of an Airstream trailer around 3 p.m. on State Route 12E in Watertown, New York.

Woroniecka, 58, was in the trailer with her family while her husband Robert, 59, pulled the trailer in a pick up truck.

Witnesses told police they saw the passenger door of the trailer swing open, helped by the wind, and watched as she hung onto the door before falling, according to a police statement. Woroniecka fell on the side of the road and was taken by Cape Vincent Ambulance to Samaritan Medical Center, where she was pronounced dead.

“Stony Brook Medicine is deeply saddened to learn of the tragic loss of one of our esteemed colleagues over the weekend, Dr. Monika Woroniecka, a physician at Stony Brook Children’s Hospital,” Stony Brook Medicine officials said in a statement. “Our thoughts are with her family, friends and colleagues affected by this heartbreaking event.”

A police spokesman in Watertown, Sgt. Jack Keller, indicated an investigation into how the door came open during travel was continuing.

“In my over 25 years [with the police], I’ve never seen an incident like this,” Sgt. Keller said. “We’re investigating it as an accident.”

The police are still gathering details as they make sure they are “thorough in our investigation,” Sgt. Keller said.

According to New York State Vehicle and Traffic law, it is illegal to ride in a camper in New York unless it has a fifth wheel connection, which provides a rigid connection directly to the frame of the vehicle towing the camper. A camper attached to a vehicle using a ball hitch does not provide that rigid connection during towing.

The camper in the accident had been connected with a ball hitch.

Police sources added that campers towed behind vehicles do not have airbags or seat belts.

Airstream did not return an email for comment.

Dr. Woroniecka had been practicing medicine since the early 2000s and specialized in allergy-immunology. She treated children with food, environmental, medications and bee sting allergies. She also treated childhood asthma and skin conditions like eczema and hives.

Dr. Woroniecka had extensive experience evaluating children for immunity disorders and frequent infections, a Stony Brook Medicine page indicated.

Dr. Woroniecka’s native language was Polish. Some of her patients from Polish-speaking families traveled considerable distances to meet with her.

Her profile on Stony Brook Medicine indicated she “enjoys working with children and their families and developing a long-term relationship with families while guiding them through chronic allergy-related conditions,” She also indicated she liked to travel, hike, exercise and spend time with family and friends.

by -
0 350
Tobias Janowitz and Hassal Lee. Photo by Caryn Koza

By Daniel Dunaief

Before treatments for any kind of health problem or disease receive approval, they go through a lengthy, multi-step process. This system should keep any drugs that might cause damage, have side effects or be less effective than hoped from reaching consumers.

In the world of cancer care, where patients and their families eagerly await solutions that extend the quality and quantity of life, these clinical trials don’t always include the range of patients who might receive treatments.

Hassal Lee. Photo by Caryn Koza

That’s according to a recent big-picture analysis in the lab of Cold Spring Harbor Laboratory Professor Tobias Janowitz. Led by clinical fellow Hassal Lee, these researchers compared where clinical trials occurred with the population near those centers.

Indeed, 94 percent of United States cancer trials involve 78 major trial centers, which were, on average, in socioeconomically more affluent areas with higher proportions of self-identified white populations compared with the national average.

“We should test drugs on a similar population on which we will be using the drugs,” said Lee. In addition to benefiting under represented groups of patients who might react differently to treatments, broadening the population engaged in clinical trials could offer key insights into cancer. Patient groups that respond more or less favorably to treatment could offer clues about the molecular biological pathways that facilitate or inhibit cancer.

Janowitz suggested that including a wider range of patients in trials could also help establish trust and a rapport among people who might otherwise feel had been excluded.

The research, which Lee, Janowitz and collaborators published recently as a brief in the journal JAMA Oncology, involved using census data to determine the socioeconomic and ethnic backgrounds of patient populations within one, two and three hour driving distances to clinical trials.

The scientists suggested researchers and drug companies could broaden the patient population in clinical trials by working with cancer centers to enlist trial participants in potential life-extending treatments through satellite hospitals.

Project origins

This analysis grew out of a study Janowitz conducted during the pandemic to test the effectiveness of the gerd-reducing over-the-counter drug famotidine on symptoms of Covid-19.

Janowitz generally studies the whole body’s reaction to disease, with a focus on cancer associated cachexia, where patients lose considerable weight and muscle mass. During the pandemic, however, Janowitz, who has an MD and PhD, used his scientific skills to understand a life-threatening disease. He designed a remote clinical trial study in which participants took famotidine and monitored their symptoms.

While the results suggested that the antacid shortened the severity and duration of symptoms for some people, it also offered a window into the way a remote study increased the diversity of participants. About 1/3 of the patients in that population were African American, while about 1/4 were Hispanic.

Lee joined Janowitz’s lab in early 2022, towards the end of the famotidine study. 

“The diverse patient population in the remote trial made us wonder if commuting and access by travel were important factors that could be quantified and investigated more closely,” Janowitz explained.

Lee and Janowitz zoomed out to check the general picture for cancer clinical trials.

To be sure, the analysis has limitations. For starters, the threshold values for travel time and diversity are proof of concept examples, the scientists explained in their paper. Satellite sites and weighted enrollment also were not included in their analysis. The cost other than time investment for potential clinical trial participants could present a barrier that the researchers didn’t quantify or simulate.

Nonetheless, the analysis suggests clinical trials for cancer care currently occur in locations that aren’t representative of the broader population.

The work “leveraged freely available data and it was [Lee’s] effort and dedication, supported by excellent collaborators that we had, that made the study possible,” Janowitz explained.

Since the paper was published, Cancer Center directors and epidemiologists have reached out to the CSHL scientists.

Searching for clinical research

After Lee, who was born in Seoul, South Korea and moved to London when she was five, completed her MD and PhD at the University of Cambridge, she wanted to apply the skills she’d learned to a real-world research questions.

She found what she was looking for in Janowitz’s lab, where she not only considered the bigger picture question of clinical trial participation, but also learned about coding, which is particularly helpful when analyzing large amounts of data.

Lee was particularly grateful for the help she received from Alexander Bates, who, while conducting his own research in a neighboring lab in the department of Neurobiology at the MRC Laboratory of Molecular Biology in Cambridge, offered coding coaching.

Lee described Bates as a “program whiz kid.”

A musician who enjoys playing classical and jazz on the piano, Lee regularly listened to music while she was in the lab. Those hours added up, with Spotify sending her an email indicating she was one of the top listeners in the United Kingdom. The music service invited her to an interview at their office to answer questions about the app, which she declined because she had moved to the United States by then.

The top medical student at Cambridge for three years, Lee said she enhanced her study habits when she felt unsure of herself as a college student.

She credits having great mentors and supportive friends for her dedication to work.

Lee found pharmacology one of the more challenging subjects in medical school, in part because of the need to remember a large number of drugs and how they work.

She organized her study habits, dividing the total number of drugs she needed to learn by the number of days, which helped her focus on studying a more manageable number each day.

Lee will be a resident at Mt. Sinai Hospital later this year and is eager to continue her American and New York journey.

As for the work she did with Janowitz, she hopes it “really helps people think about maintaining diversity in clinical trials using data that’s already available.”

by -
0 517
From left, Jack Anderson, former deputy director for Operations, Rep. Nick LaLota and John Hill, deputy director for Science & Technology tour BNL facilities. Photo courtesy office of Rep. Nick LaLota
1 of 3
Congressman LaLota, EIC Science Director and SBU professor Abhay Deshpande (middle), and Lab Director JoAnne Hewett (right) at the sPHENIX Detector. (Kevin Coughlin/Brookhaven National Laboratory)
Congressman LaLota and SRX Lead Beamline Scientist Andrew Kiss at the SRX Beamline at the National Synchrotron Light Source II. (Kevin Coughlin/Brookhaven National Laboratory)
From left, Jack Anderson, former deputy director for Operations, Rep. Nick LaLota and John Hill, deputy director for Science & Technology tour BNL facilities. Photo courtesy office of Rep. Nick LaLota

By Daniel Dunaief

With support from state political leaders and the federal government, Brookhaven National Laboratory is continuing to move forward with its ambitious plans to build the Electron-Ion Collider.

Designed to study strong forces inside the atom, the EIC is set to receive $97.9 million from the federal government as a part of a budget that passed last month.

In addition, the Department of Energy Under Secretary for Science and Innovation approved Critical Decision 3A, which gives the project the formal approval to purchase long-lead procurements such as equipment, services, and materials.

“Passing this milestone and getting these procurements underway will help us achieve our ultimate goal of efficiently delivering a unique high-energy, high-luminosity polarized beam electron-ion collider that will be one of the most challenging and exciting accelerator complexes every built,” EIC Project Director Jim Yeck said in a statement.

Buying materials and equipment for the accelerator, detector, and infrastructure before construction will help the team that includes a partnership with Thomas Jefferson National Accelerator Facility in Virginia adjust for any supply chain issues and work out technical details and challenges.

The government approval will allow for the purchase of about $90 million in superconducting wires and materials for making magnets, cryogenic equipment for superconducting accelerator devices, substations, new power supply and other specialized parts.

The funding for these purchases will come, in part, from the Inflation Reduction Act money awarded to the EIC in 2022 to stimulate economic development and through annual appropriations funding from the DOE Office of Science.

Applications 

Scientists expect the work at the accelerator, which will include a first of its kind 2.4 mile circumference particle collider, to have applications in a wide range of fields, from nuclear physics, to medicine, to energy and national defense.

The work could also help with the study of simulated space radiation that could protect future astronauts. The completion of the EIC could dovetail with upcoming National Aeronautics and Space Administration efforts to send astronauts to Mars in the 2030s.

The collider and the work that leads up to its construction, which is expected to cost between $1.7 billion and $2.8 billion and be completed in the next decade, will provide educational and workforce development opportunities to train experts in a range of fields.

Political support

In addition to government approval to purchase services and equipment from the 2022 Inflation Reduction Act, BNL also received funds earmarked for the EIC from the recent federal budget.

With bi-partisan support of politicians including Senate Majority Leader Chuck Schumer (D) and U.S. Rep. Nick LaLota (R-NY1), the recent budget includes $97.9 million for the collider, $95 million of which will support construction and $2.9 million for other projected costs.

“We appreciate the continued support of Congressman LaLota, Senator Schumer and the entire New York delegation for the U.S. Department of Energy’s Office of Science and Brookhaven National Laboratory,” Lab Director JoAnne Hewett explained in an email. “These funds will support staff working on the EIC project design and developing a baseline schedule and funding profile, allowing us to better plan the future transition of the Relativistic Heavy Ion Collider and its workforce to this new, world-class facility.”

In building the EIC, BNL staff will use infrastructure from RHIC. The majority of EIC accelerator components are designed to fit within the existing RHIC tunnel, and will reuse key infrastructure.

“It’s important that members of Congress use their positions to advocate for important projects and spending in their districts,” LaLota said in an interview. Though he’s a freshman Congressman who was elected in 2022, taking over the seat previously held by Lee Zeldin (R-NY1), LaLota appreciates the support Republican leadership provided during appropriations.

LaLota said procuring the funding “wasn’t easy” given the competitive nature of government spending.

LaLota, who plans to visit BNL every four or five months to receive updates, urges sustained federal government investment in the collider and infrastructure.

BNL provides a “vital role in high quality employment” for Long Islanders, he added.

Long Island will benefit from the EIC in the short term through construction jobs, infrastructure employment and the various applications of research on site to areas including military and commercial applications, the congressman added.

Through taxpayer funding, BNL helps ensure a “stronger military and economy,” LaLota said.

During his visits to the DOE lab, LaLota spoke with Hewett, whom he describes as a “steady hand” who serves as a “real conduit between the lab and Congress” advocating for the lab’s needs.

Solar cells

BNL conducts research in a range of fields, including Energy & Photon Sciences, Environment, Biology, Nuclear Science & Nonproliferation, Computational Sciences, Nuclear & Particle Science and Advanced Technology Research.

LaLota describes himself as an “all-of-the-above energy Republican,” who supports alternative resources, such as the ones BNL scientists are developing and enhancing.

Homeownership problem

Apart from BNL, LaLota addressed broader questions, including the challenge of homeownership for New York residents.

New York has the “dubious distinction of having the highest effective tax rate” when combining property, sales and income taxes, which has led to the highest out of state migration, LaLota said.

Without a better tax policy, New York will continue to hemorrhage people to places like the Carolinas and Florida, he predicted.

“Most of that starts in Albany,” LaLota said. “I would encourage my friends in Albany to figure that out and make life more affordable” by increasing state and local tax deductions.

As for the ability of Speaker of the House Mike Johnson (R-LA) to continue in a role some Republicans are prepared to challenge, LaLota suggested the speaker should play “every game like it’s his last.”

LaLota added that Johnson should “smartly move forward funding the government, as he has,” and “smartly move forward on funding of military aid overseas.”

by -
0 199
METRO photo

By Daniel Dunaief

Daniel Dunaief

We have learned to be impatient. Combining our instant gratification experiences with the information, access and communication at our fingertips, we have less tolerance to wait for anything.

When we find out we’ll have to stand in line for a meal for more than half an hour, we dive into our phones, searching for other nearby restaurants where we can eat within 10 minutes or less.

When we wait on the phone for customer service, we shake our heads, bite our lips, roll our eyes and sigh repeatedly while waiting for someone who encourages us to try the app or to use the automated system next time.

We want life to be at least as good if not better today than yesterday and we want that now. It’s a tough time to have to demonstrate patience and to show that we understand that life involves processes.

When we recover from an injury, we want to look at the damaged part of our bodies and, like Superman, somehow fix it by glaring at it or willing the cells involved in the process to work faster and to allow us to run on a stress fracture in our foot or to self-heal a torn rotator cuff so we can go back out and play tennis or softball again.

It’s tough to celebrate or appreciate small victories because we know where the finish line of our recovery is, where the endpoint of our request is and whatever we want immediately.

Perhaps we need to recalibrate our expectations to understand and appreciate what small wins look like. While we know what we’d like with the end result, we can see small improvements as a way to enjoy the moment and to understand and appreciate how we’re on the right track.

In recovering from my stress fracture, I have been impossibly impatient, staring at the treadmill the way I used to long for an ice cream sundae with hot caramel and chocolate sprinkles.

The treadmill, where I overdid my exercise routine and created the stress fracture, had been a source of relief.

Several times over the last few weeks, I was tempted to see if I could restart my running, only to decide, reluctantly, that I would be jeopardizing my longer term recovery.

Instead, I limited my walking and have appreciated how much better my foot feels when I maneuver around the house. The recovery isn’t complete, but the improvement, which seemed imperceptible at first, is now noticeable.

Recently, on a short walk with my dog, I spoke with a friend whose mother was celebrating a milestone birthday. Paul was frustrated with the lower quality of life that his mother is enduring, as she struggles with her memory and doesn’t enjoy many of the same things, like food and family, that used to bring her pleasure.

Paul wondered at the regular frustration he felt at the incremental losses he, his mother and their family felt each day.

While both my brothers are doctors, as was my father, I have no medical training, which makes it impossible for me to offer an informed opinion on the cognitive and physical processes that occur at the end of people’s lives.

That didn’t stop me from suggesting ways to find small wins each day, which may depend on the mental state of his mother.

At some point, those wins, whether they involve a memory of something meaningful to his mother, a card game that reaches completion, or a song she enjoys hearing can become the focus of a visit, rather than the parts she and they lose, can become the new yardstick for a win.

Impatience for something better immediately is a luxury, as are so many other aspects of life, we take for granted.

When the light turns green, we want to make the light so we can reach our destination. At the same time, a red light can give us a few extra seconds to look at the spring flowers blooming around someone’s house, to hear children shouting with delight as they pile into a car on the way to their youth soccer game, or to extend a conversation that might otherwise end when we step out of the car.

by -
0 514
From left, Juan Jimenez and Sanjaya Senanayake in front of CO2 and Methane Conversion Reactor Units in the Chemistry Division at Brookhaven National Laboratory. Photo by Kevin Coughlin/BNL

By Daniel Dunaief

If we had carbon dioxide glasses, we would see the gas everywhere, from the air we, our pets, and our farm animals exhale to the plumes propelled through the smokestacks of factories and the tail pipes of gas-powered cars.

Juan Jimenez. Photo by Kevin Coughlin/BNL

A waste product that scientists are trying to reduce and remove, carbon dioxide is not only a part of the photosynthesis that allows plants to convert light to energy, but it also can be a raw material to create usable and useful products.

Juan Jimenez, a postdoctoral researcher and Goldhaber Fellow at Brookhaven National Laboratory, has been working with carbon dioxide for the last 10 years, in his undergraduate work at CUNY City College of New York, for his PhD at the University of South Carolina and since he arrived at BNL in 2020. 

Jimenez contributed to a team led by engineers at the University of Cincinnati to create a way to improve the electrochemical conversion of this greenhouse gas into ethylene, which is an important ingredient in making plastics as well as in manufacturing textiles and other products.

University of Cincinnati Associate Professor Jingjie Wu recently published work in the journal Nature Chemical Engineering in which they used a modified copper catalyst to improve the electrochemical conversion of carbon dioxide into ethylene.

“I’m always looking out to collaborate with groups doing cutting edge research,” explained Jimenez, who spearheaded the research at the National Synchrotron Lightsource II. “Since the work on CO2 is a global concern we require a global team” to approach solutions.

Jimenez is fascinated with carbon dioxide in part because it is such a stable molecule, which makes reacting it with other elements to transform it into something useful energy intensive.

A modified copper catalyst helped convert more carbon dioxide, which breaks down into two primary carbon-based products through electrocatalysis, into ethylene, which has been called the “world’s most important chemical.”

“Our research offers essential insights into the divergence between ethylene and ethanol during electrochemical CO2 reduction and proposes a viable approach to directing selectivity toward ethylene,” UC graduate student Zhengyuan Li and lead author on the paper, said in a statement.

A previous graduate student of Wu, Li helped conduct some of the experiments at BNL.

This modified process increases the selective production of ethylene by 50 percent, Wu added.

The process of producing ethylene not only increases the production of ethylene, but it also provides a way to recycle carbon dioxide.

In a statement, Wu suggested this process could one day produce ethylene through green energy instead of fossil fuels.

Jimenez’s role

Scientists who want to use the high-tech equipment at the NSLS-II need to apply for time through a highly competitive process before experimental runs.

Jimenez led the proposal to conduct the research on site at the QAS and ISS beamlines.

Several of the elements involved in this reaction are expensive, including platinum, iridium, silver and gold, which makes them prohibitively expensive if they are used inefficiently. By using single atoms of the metal as the sites, these scientists achieved record high rates of reaction using the least possible amount of material.

The scientists at BNL were able to see the chemistry happening in real time, which validated the prediction for the state of the copper.

Jimenez’s first reaction to this discovery was excitement and the second was that “you can actually take a nap. Once you get the data you’re looking for, you can relax and you could shut your eyes.”

Working at NSLS-II, which is one of only three or four similar such facilities in the United States and one of only about a dozen in the world, inspires Jimenez, where he appreciates the opportunity to do “cutting edge” research.

“These experiments are only done a few times in the career of the average scientist,” Jimenez explained. “Having continuous access to cutting edge techniques inspires us to tackle bigger, more complicated problems.”

In the carbon dioxide research, the scientists drilled down on the subject, combining the scope of what could have been two or three publications into a single paper.

Indeed, Nature Chemical Engineering, which is an online only publication in the Nature family of scientific journals, just started providing scientific papers in the beginning of this year.

“Being part of the inaugural editions is exciting, specifically coming from a Chemical Engineering background” as this work was published along with some of the “leading scientists in the field,” said Jimenez.

New York state of mind

Born in Manhattan, Jimenez lived in Queens near Jamaica until he was 11. His family moved into Nassau County near the current site of the UBS Arena.

During his PhD at the University of South Carolina, Jimenez spent almost a year in Japan as a visiting doctoral student, where he learned x-ray absorption spectroscopy from one of the leading scientists in the field, Professor Kiyotaka Asakura. Based in Hokkaido University in Sapporo, Japan, Jimenez enjoyed touring much of the country.

A resident of Middle Island, Jimenez likes to run and swim. He enjoys cooking food from all over the world, including Spanish, Indian and Japanese cuisines.

As a scientist, he has the “unique luxury” of working with an international audience, he said. “If you are having lunch and you see someone eating amazing Indian food, you can talk to them, learn a bit about their culture, how they make their food, and then you can make it.”

As for his work, Jimenez explains that he is drawn to study carbon dioxide not just for the sake of science, but also because it creates a “pressing environmental need.”

He has also been looking more at methane, which is another potent greenhouse gas that is challenging to activate.

Ideally, at some point, he’d like to contribute to work that leads to processes that produce negative carbon dioxide use.

by -
0 361
Stony Brook University Hospital launches meal-ordering app. Photo courtesy Stony Brook Medicine/Rob Tannenbaum

By Daniel Dunaief

From soup to nuts – along with pictures and descriptions – patients at Stony Brook University Hospital can use a new mobile app to order meals during their stays that are consistent with medical advice and that is sensitive to their diets.

With this app, patients can choose the times they want meals, within the 7 a.m. to 7 p.m. schedule, and the specific foods that suit their interests and restrictions.

The response among patients at the hospital, which serves more than 1,500 patient meals a day, has been “very positive,” said Nicole Rossol, Chief Patient Experience Officer at Stony Brook University Hospital. “It’s giving patients more day-to-day control in a hospital setting.”

That empowers patients who can otherwise be confined to their rooms or to the hospital as medical staff monitors their health and brings them for a variety of tests.

The cbord patient app, which allows patients to order food for the same or the next day, provides choices that are consistent with the approach the hospital takes as a part of a patient’s care. Additionally, the app can adjust for a range of allergies and patient dietary needs.

Once patients create a dietary profile, the app can filter food options that include halal, kosher, gluten-restricted, vegetarian, cardiac, carbohydrate-controlled and more.

The app “is not replacing anything,” said Kathleen Logsdon Carrozza, Assistant Director of Food and Retail Services and Registered Dietitian at the Faculty Student Association of Stony Brook University Hospital. “It gives patients another option.” Patients who are tech savvy can use their own mobile devices to order food or, on some floors, they can use a shared mobile device.

Those who prefer can still order food through a call center or by speaking with a dining service worker.

At this point, the hospital has about 45 patients who are using the app, said Alexandra Bush, Nutrition Software Systems Administrator at the Faculty Student Association of Stony Brook University.

App origin

About a year ago, members of SBU attended a conference where they learned about this way of ordering food as an option.

“We wanted to do something that was user friendly,” said Logsdon. “The administration was on board.”

Each food and drink option includes a photograph, which gives patients a chance to consider their choices the way they might at a restaurant.

Last summer, two Stony Brook University students took pictures of each item.

At this point, the app is only available in English, although the hospital has interpreters who can help with patient needs and answer questions.

The app is evolving on almost a daily basis. Bush, who receives daily post it notes with suggestions, recently received a request from a pediatric nurse to add pasta with butter, which is now on the menu.

While the hospital doesn’t have the equivalent of a Yelp review for each dish, volunteers solicit feedback from patients from survey data.

In putting together the menu and developing the app, Stony Brook received considerable guidance from a patient and family advisory council, who teamed up with Logsdon and Bush. The app can be accessed on any app store compatible with Apple and Andriod products.

The council “helped with the education that would be going out to patients,” said Rossol. “It’s really important that we have patients that partner with us to make some of these changes and decisions. They gave us great input and feedback.”

The ability to order meals at a particular time allows patients to dine with their visitors.

“This enables us to offer things to patients in a way we haven’t been able to do in the past,” said Rossol.

By ordering food that better suit patient tastes and interests, the hospital can also reduce the amount of food it discards at waste.

When patients order food at a time when they are out of the room for medical testing, the hospital staff can update the dining crew and revise the schedule.

The person delivering the meal can speak with the nursing staff, who can advise them to hold the food or to repeat the order at a later time, depending on the length of any schedule change.

“We’re looking at ways to enhance the patient experience using technology,” said Rossol. “We are really trying to make the experience the best it can be.”

by -
0 182
Pixabay photo

By Daniel Dunaief

Daniel Dunaief

I hope my television is well rested.

Sure, we’ve watched movies here and there. We’ve gone through all the episodes of “Succession.” We’re also looking forward to the next chapters in the Keri Russell political drama “The Diplomat.”

My television, however, gets a different kind of attention during the upcoming baseball season. No, I don’t watch every Yankees game, even though, if I had the time and access, I probably would catch some of each game.

As a passionate Yankee fan, I have glared at the TV, barked at it (well, and the players on the screen at any given time) and even threatened to pick it up and throw it out the window once in a while.

Incidentally, I’ve never damaged a TV during a baseball season, no matter how frustrated I might get at the number of runners left on base, at the manager for taking someone out or at the players for not driving in a runner from third with fewer than two outs.

Long ago, I watched Game 6 of the 1986 World Series, when the Mets came back from a seemingly insurmountable deficit in the bottom of the ninth inning against the Boston Red Sox for a win that sent the series to a final game. Surrounded by gloating Red Sox fans, I watched as the game unraveled.

With my roommate in tow — we were both rooting for the Mets because he had placed a bet he couldn’t afford to lose and, as a Yankees fan, I had to support any team that played the Red Sox — we walked silently out of a room filled with furious fans.

Just before we opened the door to leave the apartment, the TV we had been watching crash-landed at our feet, exploding into numerous pieces. That night, we joined a small band of New Yorkers cheering “let’s go Mets,” while we stayed far from TV projectile range.

In this millennium, of course, the Red Sox have faired far better than both New York teams, winning four titles compared with one for the Yankees and none for the Mets.

Returning to this season, I’m sure I’ll watch the slow motion replay of a pitch that dives well outside the strike zone that will cause one of the monster hitters on the Yankees to look like they are swinging a fly swatter at an evasive insect.

At that point, I’ll tell the TV how I had told the hitter not to swing and that he should have listened to me.

Yes, I will blame the TV for not communicating somehow with the batter that I knew it.

Fortunately for me, the TV will never remind me of the times I instructed the hitter not to swing at a pitch, only to celebrate when that player crushed a game winning hit into the gap in left center field, scoring the runner sprinting home from first.

The TV will undoubtedly also hear me affix blame at its electronic feet when the channel suddenly doesn’t come in, becomes pixelated or freezes just as a critical full count pitch reaches the plate.

I could check online to see what happened, but I’d rather watch it unfold live, excruciating as the result may be when the Yankees lose yet another winnable game.

The TV knows baseball is a wonderful, miserable experience for me on some days, while it’s a miserable, wonderful one on others.

As I watch an enormous Yankees lead dissolve slowly, the TV and I both know that any opponent – even, gasp!, the Red Sox – can still win.

On the other hand, the Yankees can take a few hard punches to their solar plexus and do the same, setting a comeback record.

If you could ask my TV, he’d tell you that I’m nervous about this season. We have a few important parts, but not enough depth, particularly among our pitchers.

My TV knows that the marathon baseball season will be filled with numerous dramatic rises and falls. It also knows my tendency to turn the channel as soon as the other team records the final out against the Yankees.

Fortunately, my TV gets a break during All Star weekend and in November. The TV should fasten its seatbelt. It’s a long and likely bumpy ride between now and then.

by -
0 327
From left, Mikala Egeblad and Xue-Yan He. Photo from Constance Brukin

By Daniel Dunaief

They both have left Cold Spring Harbor Laboratory, but the innovative research they did on Long Island and that they continue to do, is leaving its mark.

From left, Mikala Egeblad and Xue-Yan He at the American Association for Cancer Research (AACR) annual meeting in New Orleans, Louisiana in 2022. Photo from Xue-Yan He

When Xue-Yan He was a postdoctoral researcher in the lab of Mikala Egeblad, who was Associate Professor at CSHL, the tandem, along with collaborators, performed innovative research on mice to examine how stress affected the recurrence and spread of cancer in a mouse model.

In a paper published in late February in the journal Cancer Cell, He, who is currently Assistant Professor of Cell Biology & Physiology at Washington University School of Medicine in St. Louis, discovered that stress-induced neutrophil extracellular traps (NETs), which typically trap and kill bacteria, trigger the spread of cancer.

“The purpose of our study is to find out what stress does to the body” of an animal model of cancer, said He.

The data in mice demonstrated that targeting NETs in stressed animals significantly reduced the risk for metastases, He explained, suggesting that reducing stress should help cancer treatment and prevention. The researchers speculate that drugs preventing NET formation can be developed and used as new treatments to slow or stop cancer’s spread.

To be sure, this finding, which is encouraging and has generated interest among cancer scientists and neurobiologists, involved a mouse model. Any potential application of this research to the diagnosis and treatment of people will take considerably more effort.

“I want to stress that the evidence for the link between stress, NETs, and cancer is from mouse studies,” Egeblad explained. “We will need to design human studies to know for sure whether the link also exists for humans.”

Still, Egeblad hopes that eventually reducing stress or targeting NETs could be options to prevent metastatic recurrence in cancer survivors. “One major challenge is that a cancer diagnosis by itself is incredibly stressful,” she explained. The results of these experiments have attracted considerable attention in the scientific community, where “there is a lot more to learn!” 

Three part confirmation

When she was a postdoctoral researcher, He removed neutrophils from the mice using antibodies. Neutrophils, which are cells in the immune system, produce the NETs when they are triggered by the glucocorticoid stress hormone.

She also injected an enzyme called DNAse to destroy NETs in the test mice. The former CSHL postdoctoral researcher also used genetically engineered mice that didn’t respond to glucocorticoids.

With these approaches, the test mice developed metastasis at a much lower rate than those that had intact NETs. In addition, chronically stressed mice who didn’t have cancer had NETs that modified their lung tissue.

“Stress is doing something to prepare the organs for metastasis,” said He.

Linda Van Aelst, CSHL Professor and a collaborator on the study, suggested that this work validates efforts to approach mental health in the context of cancer.

“Reducing stress should be a component of cancer treatment and prevention,” Van Aelst said in a statement.

After He removed the primary tumor in the mouse models, the stressed mice developed metastatic cancer at a four-fold higher rate than the mice who weren’t stressed but who also previously had cancer.

The CSHL scientists primarily studied breast cancer for this work.

He appreciated the help and support from her colleagues at CSHL. “To really understand the mechanism” involved in the connection between stress and cancer, “you need a mouse model in the lab, an expert in neuroscience and an expert in the cancer field,” she said.

As a neuroscientist, Van Aelst offered suggestions and comments and helped He conduct behavioral tests to determine a mouse’s stress level. The work for this project formed the focus ofHe’s postdoctoral research, which started in 2016 and ended in 2023.

The link between stress and cancer is receiving increasing attention in the scientific community and has attracted attention on social media, He said.

CSHL “provided a great environment to perform all these experiments,” said He. The numerous meetings CSHL hosts and the willingness of principal investigators across departments made the lab “one of the best places” for a postdoctoral scientist.

“If you need anything from a neural perspective or a technical perspective, you can always find a collaborator” at CSHL, He added.

Born and raised in Nanjing, China, He enjoyed living on Long Island, visiting vineyards and trying to explore every state park. In the harbor, He caught blue crabs while her husband Chen Chen, who was a postdoctoral researcher at CSHL in the lab of Camila dos Santos, went fly fishing at Jones Beach.

In her current research, where she manages a lab that includes a senior scientist, a postdoctoral researcher and an undergraduate, He is extending the work she did at CSHL to colorectal cancer, where she is also analyzing how stress affects the spread of cancer.

“When you’re stressed, you can develop gastrointestinal problems, which is why I wanted to switch from breast cancer to colorectal cancer,” she said.

Extensions of the work

As for context for the research at CSHL, Egeblad wrote that doctors treating patients where the known risk of recurrence is high might use NETs in the blood as a biomarker.

The scientists think cancers that tend to metastasize to the liver, lung or spleen are the strongest candidates to determine the effect of NETs and stress on cancer.

“We have not seen any effects of targeting NETs for metastasis to the bone or the brain in our mouse model and similarly, the studies that have linked NETs to metastasis in human patients have mostly been cancer that has spread to the liver or the lung,” Egeblad said.

Egeblad appreciated the “fantastic job” He did on the work and described her former researcher as being “fearless.”

“She found that stress increased metastasis early in her project but it was a lot of work to discover it was the NETs that were responsible and to conduct studies to ensure that the results were applicable to different types of cancer,” Egeblad explained.

While the two researchers have gone to different institutions and are leading other lab efforts, Egeblad said she’d be happy to collaborate with her former student, who shares the same sense of humor.

Egeblad recalled how He ended her talks by telling the audience that her results showed that Egeblad should give her a “long vacation.”

“I think indeed that she has deserved one after all this work!” Egeblad offered.

by -
0 263
Salvatore Capotosto hugs his wife Federica Bove at Stony Brook Medicine Match Day 2024. Kristy Leibowitz

 

By Daniel Dunaief

A former professional soccer player from Italy, Salvatore Capotosto recently experienced a different kind of pressure, this time in front of his wife and her parents.

Joining the rest of the Renaissance School of Medicine at Stony Brook University class of 2024, Capotosto awaited the countdown for Match Day to learn where he would serve his residency. 

Capotosto, who already knew he’d matched with one of the hospitals on his list for an orthopedic surgery residency, opened the same kind of envelopes medical students around the country were opening at noon Eastern Standard Time.

After the countdown, Capotosto learned he matched with his first choice, Mt. Sinai Hospital in New York City.

“It’s a very great dream for us,” said Capotosto, referring both to the opportunity for him and his wife Federica Bove to live in the city and to the excitement his extended family in the small town of Itri felt. Reading where he was going was “an explosion of emotion.”

Capotosto and Bove shed tears of happiness as they pondered the next step in an American journey that began eight years ago when they started college at Midwestern State University in Wichita Falls, Texas. While Capotosto received medical training at Stony Brook, Bove earned her Master of Business Administration at Pace University.

The first member of his family to become a physician,  Capotosto said he spent considerable time explaining the lengthy residency and matching process to his family.

“It doesn’t matter how many millions of times” he shared the medical steps with them, he said, “they will still ask” about the next steps.

Humble origins

The son of cafe owner Luigi, the future orthopedic surgery resident didn’t always set his sights on either a high-powered athletic career or on becoming an American doctor.

“I used to walk to school and stop at my dad’s cafe and eat a croissant and drink cappuccino for breakfast and I would scream that I didn’t want to go to school and that I wanted to work at the cafe,”  Capotosto said. His father kicked him out of the cafe and told him to “go study.”

The Capotosto son said he learned his work ethic from his extended family, for whom work is a responsibility and a passion. Watching his father put time and effort into his work helped him put in 100 or more hours some weeks to meeting his responsibilities and mastering medical material.

Capotosto hasn’t been able to convince his father visit him in New York since he arrived on campus. This year, however, his parents booked a trip to see their son graduate.

Packages from home supported him through school and helped reduce the distance from his close family, who sent olives and olive oil every few months that were made from the 200 olive trees on his grandfather Pietro Mancini’s property.

A rising soccer star

Capotosto developed a passion for soccer when he first started playing the game at the age of six. He poured considerable energy into developing as a goalie.

He achieved considerable success, playing in front of crowds of over 4,000 people for professional and semi professional teams. In Naples, he trained with his idol, goalkeeper Morgan De Sanctis.

Capotosto was in the academy of the professional Napoli team for four years, including training with the first team.

When he played soccer, Capotosto suggested he was a “perfectionist,” honing his technique through hard work and preparation.

During his playing days, Capotosto sustained several injuries that took him off the field, including a scaphoid bone injury that ended his career.

Unsure of the next steps in his life, Capotosto appreciated not only the help and support of the doctors who came to his aid on the field, but also the career inspiration.

“I like to say that orthopedics saved my life,” Capotosto said. “Without the flame to push me to stand up and find a new purpose, I would have taken wrong turns in those dark moments. I’m really grateful to this field.”

Some of Capotosto’s mentors at Stony Brook, in turn, appreciate the considerable positive energy the former goalie brings to medicine and the way he relates to everyone from hospital staff to patients.

“He’s immediately disarming,” said Dr. James Penna, orthopedic surgeon and Chief of Sports Medicine at the Renaissance School of Medicine at Stony Brook University. “Even patients who are scared or who are dealing with pain” relax when they are around him.

Dr. Edward Wang, Chief of Shoulder/Elbow Surgery and Clinical Professor in the Department of Orthopedics at the Renaissance School of Medicine, recalled that he offered Capotosto the opportunity to shadow him in the operating room early in his medical school career.

Capotosto picked up the do’s and don’ts of the operating room quickly, while the members of the team recognized his dedication and commitment.

“The staff took a real liking to him immediately,” Dr. Wang said. “Orthopedics is lucky he chose” the field.

In the last few months, Capotosto, who is 29 years old, has reached several milestones. He and Bove received green cards in February, which allow them to live and work permanently in the United States. The couple, who met when Capotosto was 18, also got married on April 22 in Central Park. They are planning a religious ceremony in Italy in May at Bove’s childhood church.

Sports and medicine

The field of orthopedics has attracted athletes from numerous sports, as former competitors have turned their focus and dedication towards preparing for games to the challenging world of helping people recover from injuries.

“A large percentage of applicants have some sorts of sports background,” with numerous doctors sharing stories about injuries such as a torn anterior cruciate ligament or about a relative who received knee replacement surgery, said Dr. Penna, who was not a college athlete.

“We have a lot of former athletes in our program,” added Dr. Wang, who swam competitively in a Division 1 program at the University of Miami. “Athletes like orthopedics because of the physicality and definitive nature and the exposure in the past.”

While Dr. Wang suggested that a range of character-defining elements helped shape Capotosto, he added that the former soccer star’s injuries enhanced his ability to connect.

“Being on the other side [as a patient] gives you empathy,” said Dr. Wang.

While Capotosto enjoyed his time in soccer, he is pleased with the current chapter in his life.

“Playing was a great opportunity, but, I think being an orthopedic surgeon is way better from my standpoint right now,” he said. “I believe in the mission.”

The Stony Brook medical staff, meanwhile, believes in him. 

“There will be a lot of disappointed attendees” when Capotosto leaves the school, said Dr. Penna. “The janitors knew who he was.”

by -
0 219
Pixabay photo

By Daniel Dunaief

Daniel Dunaief

I was in between that state when I’m focused on how tired I am at the gym and when the endorphins kick in, enabling my body to push harder and for longer in the interests of physical fitness and mental health.

When my cell phone rang, I wasn’t sure whether to pick it up. I’ve been getting numerous annoying robocalls from pseudo-people who want to sell me something I don’t want or need. When I ask them to take my name off their lists, they hang up and someone else from the same organization calls me back the next day.

Unless I recognize the number or am expecting an important call, I tend to let voicemail pick up while I disconnect from everything but the rhythm of checking the number of calories I’ve burned and the distance I’ve traveled during each five minute segment on the elliptical machine.

This time, however, the name looked vaguely familiar, so I stopped moving, took out the airpods that don’t work too well and picked up the phone.

“Hi, this is Dan,” I said, trying to control my breathing.

“Who is this?” the person asked.

“Dan, why, who is this?” I thought, as I considered disconnecting and returning to my routine.

“I have a number that my wife wrote down on my desk and I wanted to know who this was,” he said.

That’s when it hit me. The name was familiar because I had written a story a few weeks ago and had reached out to the couple for a comment.

He understood my explanation and asked if I were related to several other Dunaiefs he knew.

“Yup, that’s my mother,” I said proudly, awaiting words of appreciation and praise for what she’s done since she started the newspapers over 47 years ago and become a visible presence in the community.

“And Ivan?” he asked, “That’s your father?”

“Indeed,” I said.

“Well, I knew him many years ago,” he offered. “We worked together.”

I nodded and looked around the room to see if anyone were waiting to use the elliptical machine. Fortunately, no one was hovering.

“So, how is he?” he asked.

“Excuse me?” I replied, not sure I heard him correctly.

“How is Ivan doing?”

I hadn’t been asked this question in decades.

“He died in 1987,” I said, flatly.

“Oh,” he said, “1987?”

“Yes,” I said.

“Well, we all have to go sometime,” he offered. “Some sooner than others, I suppose.”

After we ended the call, I resumed my exercise. That seemed like a surprisingly flippant thing to say. The older, current version of me was annoyed, while the younger version felt vulnerable.

Once I built up a solid sweat, a broad smile filled my face, leading at least one person to ponder why I looked unusually pleased during physical exertion.

While I knew the man was processing the not-so-new news, I also decided that the person who would have taken particular delight in this slightly absurd conversation was my father.

With my legs pumping away, I shared a laugh with my father, who could make me smile no matter how frustrated or annoyed I was as a teenager.

Over time, I have enjoyed any number of opportunities to connect with people I’ve had the privilege of knowing who have died, sometimes through dreams or by watching, hearing or experiencing something I know they’d appreciate.

Recently, after my mother-in-law died, my wife received a set of wind chimes with her mother’s name inscribed on them. Before we placed the chimes, we rarely had much wind. Now, amid a steady flow of unusual breezes that bring pleasant sounds to our backyard, my wife and I smile at each other.

If we look for it, we can take comfort in the things that help us feel connected to those we’ve lost.

Prev123...147Next Page 2 of 147
TBR News Media is your local news and entertainment website.
We provide you with the latest breaking news and information for your community.
Contact us: [email protected]

Most Viewed

©