Monthly Archives: May 2015

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My mother adamantly refused to let the pediatrician remove my tonsils several decades ago. She certainly respected his expertise, having chosen him carefully after an extended search when she knew she was pregnant. But she was not going to agree with his recommended course of action despite my chronic tonsillitis.

“Do you have clinical evidence that children who have had their tonsils removed get sick less often?” she demanded of him. “No,” he responded slowly, “only anecdotal evidence. You know the tonsils have no known function and are not necessary, and hers are very large.” “Hmmph,” was my mother’s rejoinder, “not known to you doctors.” So, as you might expect, I grew up with my tonsils and still have them to this day. They are large enough to inspire each new physician who looks in my throat to exclaim over both their size and their existence in a member of my generation, but whatever role they may play in the human body, they are still playing in mine.

My mother and my father had two strongly-held beliefs: First that there were no superfluous parts to the miraculous human body and, second, that optional surgery was not an option. I am sure they were encouraged in those beliefs by the death of an only child of dear friends during an optional tonsillectomy.

Do I know if they were right? All I can offer is that history shows the apple doesn’t fall far from the tree. That is why I felt a burst of glee when I came across a recent article in The New York Times Science section headlined, “Saving the Appendix.” They stopped removing tonsils as simply a matter of course many years ago, but here was further affirmation of the parental dicta.

“Five small studies from Europe, involving a total of 1000 patients, indicate that antibiotics can cure some patients with appendicitis; about 70 percent of those who took the pills did not require surgery,” according to Gina Kolata, author of the article. As well, patients who had an appendectomy after first trying antibiotics did not face any more complications than those who went directly to surgery. This, of course, flies in the face of traditional exhortations about rushing to remove the inflamed appendix before it bursts, potentially with dangerous results.

While these studies suggest that surgery can be avoided altogether in treating appendicitis, a large-scale clinical trial must be held for verification — and one is in the planning. When patients who had already had an appendectomy were asked if they would have been willing to try antibiotics first, nearly three-quarters responded “yes.”

The appendix is “a tiny, worm-shaped tube that hangs off the right side of the colon,” Kolata said, and no one knows what it does or why it can suddenly act up. Nor does anyone know why it also can get better on its own, even without antibiotics. And antibiotics actually have been used in the past to treat an inflamed appendix.

According to The Times, during the Cold War in the 1950s, when American sailors spent at least six months on nuclear submarines that were prohibited from surfacing, patients with appendicitis were given antibiotics and no deaths or complications were reported.

To use antibiotics would, of course, eliminate the need for surgery and hospitalization where appendicitis is diagnosed, which would be both cheaper and safer. But even if it revolutionized traditional treatment, using antibiotics would not immediately answer key questions: Would the appendicitis recur? If so, how often? How much antibiotics would be required? How would the drug best be administered?

Presently, doctors don’t usually tell their patients about the antibiotics option, citing the above unanswered questions as a reason. Also we know and, for the most part, approve that medicine is a highly conservative profession, avoiding the trendy but insufficiently tested. It is hard “to go away from a 30-minute operation that cures them for the rest of their lives,” said Dr. Giana Davidson, a University of Washington general surgeon quoted in the article.

But patients are finding out on their own and some ask for this nonsurgical alternative, thanks in part to information gleaned from the Internet.

A boys’ baseball team I coached recently lost a game in such an excruciating fashion that I couldn’t rely on all the standby coach catchphrases.

“We’ll get ’em next time,” would fall flat, especially when we had them for the taking. We were up by two runs and were in complete control of the game until the final outs.

“Hey, this one’s on me.” That’s nice and can work in deflecting any possible blame, but the kids generally don’t buy into it. If they believe it, it also sets a dangerous precedent for future losses.

“Hey, coach,” they might ask at the end of another game. “This one’s clearly not on you, right? Isn’t it Johnny’s fault?”

Those final three outs never happened. What made the game even more difficult to swallow was that the other team didn’t put a single ball in play in their final at bat. Four walks, a hit batter and a few wild pitches later, we were done.

We trudged to left field for the postgame analysis and pep talk.

“Hey,” I said. “Look, uh, this is one game, right?”

I could see it in their eyes: “Weak and feeble, coach. You’re going to have to do better than that.”

“You know, we did a lot right this game.”

“Who cares,” their sullen, downcast eyes indicated.

“We lost.”

“OK, well, we can’t win them all.”

I didn’t even need to look at them to know what they were thinking. I was thinking it, too, as the words came dribbling out of my mouth. “Seriously? You’re going with that?”

“Boys, I know you all did your best.”

Their eyes moved to their parents, as if they were saying telepathically: “Get me out of here, I want to go home.”

“Hey,” I said, a small smirk on my face. “Guys, who saw Joey’s slide at second today? Was that the ugliest thing you’ve ever seen?”

Joey had wandered too far from second and would have been out if the pitcher had thrown the ball to the second baseman. When the second baseman had to move a few feet from the base, Joey dove back head first and landed flat on his chest, a yard short of the base. He crawled on his hands and knees across the dirt to the base, arriving just in time to beat the second baseman’s tag.

“That was funny,” several of them seemed to say. Joey, you see, is a bit sensitive so that comment could have been dangerous. Even he, however, offered a small smile. It was an absurd moment to savor. And, fortunately for us, he was safe, so laughing about it was probably safe.

In that final, fateful, painful inning, the first pitcher walked two and hit a batter, sending the tying run to second and the winning run to first. I brought in a tall relief pitcher who promptly walked another two batters. A wild pitch later, the game was over.

“Fred, do you know why I put you in there at the end of the game?” I asked.

“Because you believed in me?” he offered hopefully.

“Well, sure, but the real reason is that you’re much taller than me.”

Again, I was reaching for the absurd. No one looked at their parents.

“Yeah, you see, it’s not right for a 12-year-old boy to be taller than his coach. I needed to cut you down to size.”

The grin spread quickly across his face, as well as those of the other four boys who look down on me.

No, it wasn’t in the playbook, but it worked.

Young horseshoe crabs at West Meadow Beach, Stony Brook. File photo

Local fishermen came out to Brookhaven Town Hall last Thursday to let officials know they oppose Supervisor Ed Romaine’s push to limit horseshoe crab harvesting.

Earlier that week, Romaine (R) announced he and the town board would consider urging the New York State Department of Environmental Conservation, which regulates the industry, to ban horseshoe crab harvesting within 500 feet of town-owned property in an effort to protect the crab population and allow them a safe place to mate.

Romaine moved to table the idea after hearing the baymen’s concerns.

The 450-million-year-old species are used for bait and in the biomedical and pharmaceutical industries, as their blue blood is used to detect bacterial contamination in products. At a May 19 press conference, officials said if the crab population shrinks, other species — like those that eat the crabs’ eggs — could be negatively affected.

Stony Brook’s West Meadow Beach and Mount Sinai Harbor already have harvesting plans in place, and a ban would broaden the restriction area.

However, the fishermen said the restriction was not based on any facts and the horseshoe crab population is not declining. In addition, they said further regulation would affect their livelihoods.

Ron Bellucci Jr., of Sound Beach, said horseshoe crab harvesting is a vital part of his income. He added that he knows the crabs are important to the larger ecosystem, which he is a part of as well.

“I’m just a man, but I’m a vital part of the food chain and I think I’m at the top,” he said.

According to the Atlantic States Marine Fisheries Commission, a partnership between East Coast states to protect fisheries, a 2013 assessment of the horsecrab population showed a decrease in the New York and New England regions, while crabs have increased in the southern states — North Carolina through Florida — and remained stable from New Jersey through coastal Virginia.

David Klopfenstein, of the North Shore Baymen’s Association, urged the board to speak with the DEC before supporting a ban. He said there was a lot of misinformation regarding a very complex issue that is already being controlled.

“It’s also the most well-managed fisheries that we have up and down the East Coast,” he said.

The DEC did not immediately comment on the issue.

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Triglycerides is a term that most of us recognize. This substance is part of the lipid (cholesterol) profile. However, this may be the extent of our understanding. Compared to the other substances, HDL (“good” cholesterol) and LDL (“bad” cholesterol), triglycerides are not covered much in the lay press and medical research tends to be less robust than for the other components. If I were to use a baseball analogy, triglycerides are the Mets, who get far less attention than their crosstown rivals, the Yankees.

But are triglycerides any less important? It is unclear whether a high triglyceride level is a biomarker for cardiovascular disease – heart disease and stroke – or an independent risk in its own right (1) (2). This debate has been going on for over 30 years. However, this does not mean it is any less important.

What are triglycerides? The most rudimentary explanation is that they are a kind of fat in the blood. Alcohol, sugars and excess calorie consumption may be converted into triglycerides.

Risk factors for high triglycerides include obesity, smoking, a high carbohydrate diet, uncontrolled diabetes, hypothyroidism (underactive thyroid), cirrhosis (liver disease), excessive alcohol consumption and some medications (3).

What levels are normal and what are considered elevated? According to the American Heart Association, optimal levels are <100 mg/dL; however, less than 150 mg/dL is considered within normal range. Borderline triglycerides are 150-199 mg/dL, high levels are 200-499 mg/dL and very high are >500 mg/dL (3).

While medicines that focus on triglycerides, fibrates and niacin, have the ability to lower them significantly, it is questionable whether this reduction results in clinical benefits, like reducing the risk of cardiovascular events. The ACCORD Study, a randomized controlled trial, questioned the effectiveness of medication; when these therapies were added to statins in type 2 diabetes patients, they did not further reduce the risk of cardiovascular disease and events (4). Instead, it seems that lifestyle modifications may be the best way to control triglyceride levels.

Let’s look at the evidence.

EXERCISE – TIMING AND INTENSITY
If you need a reason to exercise, here is really good one. I frequently see questions pertaining to optimal exercise timing and intensity. Most of the answers are vague, and the research is not specific. However, hold on to your hats, because a recent study may give the timing and intensity answer, at least in terms of triglycerides.

Study results showed that walking a modest distance with alacrity and light weight training approximately an hour after eating (postprandial) reduced triglyceride levels by 72 percent (5). However, if patients did the same workout prior to eating, then postprandial triglycerides were reduced by 25 percent. This is still good, but not as impressive. Participants walked a modest distance of just over one mile (2 kilometers). This was a small pilot study of 10 young healthy adults for a very short duration. The results are intriguing nonetheless, since there are few data that give specifics on optimal amount and timing of exercise.

EXERCISE TRUMPS CALORIE RESTRICTION
There is good news for those who want to lower their triglycerides: calorie restriction may not the best answer. In other words, you don’t have to torture yourself by cutting calories down to some ridiculously low level to get an effect. We probably should be looking at exercise and carbohydrate intake instead.

In a well-controlled trial, results showed that those who walked and maintained 60 percent of their maximum heart rate, which is a modest level, showed an almost one-third reduction in triglycerides compared to the control group (maintain caloric intake and no exercise expenditure) (6). Those who restricted their calorie intake saw no difference compared to the control. This was a small study of 11 young adult women.Thus, calorie restriction was trumped by exercise as a way to potentially reduce triglyceride levels.

CARBOHYDRATE REDUCTION, NOT CALORIE RESTRICTION
In addition, when calorie restriction was compared to carbohydrate reduction, results showed that carbohydrate reduction was more effective at lowering triglycerides (7). In this small but well-designed study, patients with nonalcoholic fatty liver disease were randomized to either a lower calorie (1200-1500 kcal/day) or lower carbohydrate (20 g/day) diet. Both groups significantly reduced triglycerides, but the lower carbohydrate group reduced triglycerides by 55 percent versus 28 percent for the lower calorie group. The reason for this difference may have to do with oxidation in the liver and the body as a whole. Both groups lost similar amounts of weight, so weight could not be considered a confounding or complicating factor. However, the weakness of this study was its duration of only two weeks.

FASTING VERSUS NONFASTING BLOOD TESTS
The paradigm has been that, when cholesterol levels are drawn, fasting levels provide a more accurate reading. Except this may not be true.

In a new analysis, fasting may not be necessary when it comes to cholesterol levels. NHANES III data suggests that nonfasting and fasting levels yield similar results related to all-cause mortality and cardiovascular mortality risk. The LDL levels were similarly predictive regardless of whether a patient had fasted or not. The researchers used 4,299 pairs of fasting and nonfasting cholesterol levels. The duration of follow-up was strong, with a mean of 14 years (8).

Why is this relevant? Triglycerides are an intricate part of a cholesterol profile. With regards to stroke risk assessment, nonfasting triglycerides possibly may be more valuable than fasting. In a study involving 13,596 participants, results showed that, as nonfasting triglycerides rose, the risk of stroke also rose significantly (9).

Compared to those who had levels below 89 mg/dL (the control), those with 89-176 mg/dL had a 1.3-fold increased risk of cardiovascular events, whereas those within the range of 177-265 mg/dL had a twofold increase, and women in the highest group (>443 mg/dL) had an almost fourfold increase. The results were similar for men, but not quite as robust at the higher end with a threefold increase.

The benefit of nonfasting is that it is more realistic and, according to the authors, also involves remnants of VLDL and chylomicrons, other components of the cholesterol profile that interact with triglycerides and may affect the inner part (endothelium) of the arteries.

What have we learned? Triglycerides need to be discussed, just as we review HDL and LDL levels regularly. Elevated triglycerides may result in heart disease or stroke. The higher the levels, the more likely there will be increased risk of mortality – both all-cause and cardiovascular. Therefore, we ideally should reduce levels to less than 100 mg/dL.

Lifestyle modifications using carbohydrate restriction and modest levels of exercise after a meal may be the way to go to the best results, though the studies are small and need more research. Nonfasting levels may be as important as fasting levels when it comes to triglycerides and the cholesterol profile as a whole; they potentially give a more realistic view of cardiovascular risk, since we don’t live in a vacuum and fast all day.

REFERENCES:
(1) Circulation. 2011;123:2292-2333. (2) N Engl J Med. 1980;302:1383–1389. (3) nlm.nih.gov. (4) N Engl J Med. 2010;362:1563-1574. (5) Med Sci Sports Exerc. 2013;45(2):245-252. (6) Med Sci Sports Exerc. 2013;45(3):455-461. (7) Am J Clin Nutr. 2011;93(5):1048-1052. (8) Circulation Online. 2014 July 11. (9) JAMA 2008;300:2142-2152.

Dr. Dunaief is a speaker, author and local lifestyle medicine physician focusing on the integration of medicine, nutrition, fitness and stress management. For further information, go to the website www.medicalcompassmd.com and/or consult your personal physician.

Above, Morgan May at the LSST site in Cerro Pachón, Chile, last month. The dryness of the site is essential for good viewing. Water vapor in the air causes stars to twinkle, or to have blurred images. Only the heartiest small cactus can survive at this elevation and in this low moisture. The LSST site is on the southern edge of the driest desert in the world, in the middle of 85,000 acres of land which is kept undeveloped to avoid light pollution for astronomy. Photo from Morgan May

Look! Up in the sky! It’s a bird, it’s a plane, it’s … billions of galaxies. Impossible to see with the naked eye, only vaguely visible through good telescopes, these galaxies will come to life in a way never seen before when the Large Synoptic Survey Telescope starts providing images from its mountaintop home in Chile in 2020.

Before this technological wonder is completed, people like Morgan May, a physicist at Brookhaven National Laboratory, are testing to make sure this ambitious project provides clear and accurate information.

Recently, May and his colleagues at BNL conducted two tests of the telescope.

The LSST will have 200 individual silicon sensors that are the film in the 3.2 gigapixel digital camera. The process of making the sensors is imperfect, with the sensors starting out as molten mass.

Impurities or variation in the temperature can cause imperfections that look like tree rings around a central circle, which create electric fields that can cause a distortion in the image.

“Because we are trying to measure things at a much higher level of precision, the tree rings were a source of great concern,” said May, who receives funding from the Department of Energy’s Office of Science-Cosmic Frontier Research.

They found that these radial imperfections were much smaller than in previous detectors, which was already a benefit to the project. Looking at the likely actual measurements using these sensors, May and his colleagues found that these tree rings had a small effect on the data, which was a pleasant surprise, but one that took some time to prove.

In another test, May, working with Columbia University graduate student Andrea Petri, examined whether differences in the sizes of the three billion pixels in the camera might also cause problems interpreting the information.

May and Yuki Okura, a postdoctoral fellow from Japan’s RIKEN laboratory who is stationed at the RIKEN-BNL Research Center, measured how much light each pixel picked up in the detector. While the variation was small, they weren’t sure whether it was small enough to keep from causing problems with the data.

The team simulated a night sky. Once they gathered the information they would have collected from these slight pixel differences, they compared their simulated image to their original.

Fortunately for the scientists, this effect also proved manageable and won’t create confusion.

May and Okura’s work “did have a good outcome,” said Sam Aronson, director of the RIKEN BNL Research Center. “They showed that the sensor imperfections measured on the LSST sensors will not affect LSST’s science objectives.”

While May is relieved the telescope passed these two tests, he continues to search for other potential problems with this revolutionary telescope.

“I am confident the LSST is going to be successful in its goals, but we have to work very hard to follow every possible issue and resolve it,” he said.

As a part of the LSST Dark Energy Science Collaboration, May said his primary research goal is to answer the question, “What is dark energy?” May said he will be studying subtle features of enormous amounts of information that will become available. May will be researching a force that causes the universe to expand faster and faster, rather than contract.

Until the 1930s, everyone thought the universe was contracting. Edwin Hubble, for whom the Hubble Space Telescope is named, was the first to observe this expansion. It is as if a ball thrown in the air slows down as expected and then accelerates away from Earth, May said. One well-regarded hypothesis is that the universe is filled with something called dark energy that causes a gravitational force that repels rather than attracts.
Once the telescope goes online, the information will become widely available.

“We’re going to make our data public to the everyone in the United States,” said May. It will be possible for “children in high school or even elementary school to have their own galaxy or supernova.”

Born in Brooklyn, May lives on Long Island with his wife Dana Vermilye. The couple have a 23-year old son, Michael, who is in medical school and a daughter, Julia, who is a high school sophomore.

May sees cosmology and astrophysics as a new frontier in science. “It’s an area where great discoveries are being made,” he said. “If you are interested in science as an observer or a career, I would say [it’s] really in the forefront.”

Ryan Frische mugshot from SCPD

Police arrested a man at a local motel after he allegedly stole prescription medication and cash from a Port Jefferson Station pharmacy on Tuesday morning.

According to the Suffolk County Police Department, Ryan Frische, an East Northport resident, first bought hypodermic needles at the pharmacy counter of the Rite Aid in Jefferson Plaza. He then allegedly made verbal demands and gave the clerk a note that demanded cash as well as “oxy.”

With three bottles of Oxycontin pills and cash, the suspect fled the store on foot, police said.

Officers interviewed witnesses and tracked Frische, 27, to the Americas Best Value Inn on Route 112, arresting him shortly after the incident.

The Elwood Road resident was charged with third-degree robbery and third-degree criminal possession of a controlled substance.

Attorney information for the defendant was not immediately available. He was scheduled to be arraigned on Wednesday.

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Max Neilsen hurls a pitch from the mound in a Ward Melville baseball game earlier this season. File photo by Bill Landon
Max Neilsen hurls a pitch from the mound in a Ward Melville baseball game earlier this season. File photo by Bill Landon
Max Neilsen hurls a pitch from the mound in a Ward Melville baseball game earlier this season. File photo by Bill Landon

After completing the regular season with a 19-2 overall record and 16-2 mark in League I play, the No. 2 Ward Melville baseball team is hoping to power past East Islip, to take on the winner of the Connetquot/Smithtown East series in the Suffolk County Class AA finals.

After bypassing the qualifying round, the Patriots, with the help of starting pitcher Joe Barbieri, edged out and shut out No. 6 East Islip, 1-0, in the first of a three-game series.

The team traveled to its opponent on Wednesday. Should Ward Melville lose, the team will host East Islip on Thursday, at home at 4 p.m.

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Stony Brook’s B-Section is brand new. Photo from Dan Losquadro

Stony Brook has a bunch of brand new boulevards, thanks to Brookhaven bureaucrats, and residents are abuzz.

The Brookhaven Town Highway Department finished a long-anticipated road improvement project in Stony Brook last week in the area known as the B-Section, repaving 19 roads and making the neighborhood safer. Residents living in the community celebrated the milestone after more than two decades of wear and tear.

“It is a pleasure driving through the community now,” said Dr. Jay Orlikoff, who lives in the neighborhood. “The last time these roads were repaved was about 25 years ago and it was tough to get in and out of the community. This time it was very well done and the courtesy of the workers in how they directed traffic was extremely helpful.”

Highway Superintendent Dan Losquadro said the 19 Stony Brook roads have been near the top of his department’s list for more than a year, but budget constraints have limited his repaving initiatives. But as of the end of last week, the 19 roads — including Balfour Lane, Ballad Lane, Ballad Place, Barker Court, Barker Drive, Barnwell Lane, Beaverdale Lane, Bendix Lane, Bently Lane, Birdseye Circle, Blackwell Court, Blackwell Lane, Blueberry Lane, Bonnie Lane, Botany Lane, Bucknell Lane, Bunting Lane, Burgess Lane and Buxmont Lane — have new surfaces and are safer routes.

“They were in terrible condition. These were roads that, quite frankly, I wish I could have gotten to last year,” he said. “Unfortunately, as you can imagine, everything is budget-driven. There’s a finite amount of money.”

The highway superintendent said he has about 3,350 miles of road to maintain throughout Brookhaven on an annual basis, and more than $100 million worth of roadwork on his to-do list at any given time. But there is only roughly $17 million in funds available to complete the work.

“I’m trying to work my way through these roads, and one of the things I’ve tried to do with people is create a reasonable expectation,” he said. “There are three-to-five-year plans of how we need to get where we need to be, and I’m working toward that. A project like this, that can cost between three-quarters of a million dollars and $1 million, is just an extensive project.”

For the better part of a week, Brookhaven road crews took to the B-Section to rebuild concrete, curbs, drainage and paving components on the 19 roads. Residents waited patiently over several days of milling work and the end result, the superintendent said, was a safer Stony Brook.

“It is very gratifying to hear the positive feedback we have been receiving from residents in this community,” Losquadro said. “This is one more project I can check off our to-do list. The Highway Department will keep on pace to complete many more roads throughout this paving season.”

Looking ahead, Losquadro said he had another big project coming up, budget permitting, in the same vicinity near both Spyglass Lane and Buccaneer Lane, where he said roads are in terrible condition.

“We need to get in there and get that done,” he said. “With the budgetary constraints, I have to be honest with you, I can spend my entire allotment without a problem. But the residents throughout this town deserve attention. We try to do worst first.”

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Sound Beach residents observed Memorial Day and remembered the men and women lost at war on Monday. The Sound Beach Civic Association led a service at the Sound Beach Veterans Memorial Park in honor of their neighbors — William Binder, World War II; Stewart Carroll, World War II; Joseph DeGrennaro, Vietnam; Bruce Kerndl, Vietnam; Charles Prchal, Vietnam; Kerry Hein, Desert Storm; and Peter Hahn, Iraq — who died in the line of duty. Veterans and those still serving were also honored.

By Chris Setter

The Northport community held its annual Memorial Day parade and remembrance ceremony on Monday, May 25. The American Legion Post 694 of Northport hosted the event, which included participants from Boy Scouts, Girl Scouts, high school cadets, World War II veterans and more.