Brookhaven National Laboratory

JoAnne Hewett. Twitter photo

By Daniel Dunaief

Daniel Dunaief

Finally!

Brookhaven National Laboratory has had nine lab directors since it was founded in 1946. Earlier this week, the Department of Energy facility, which has produced seven Nobel Prizes, has state-of-the-art facilities, and employs over 2,800 scientists and technicians from around the world announced that it hired JoAnne Hewett as its first female lab director.

Successful, determined, dedicated and award-winning local female scientists lauded the hire of Hewett, who comes to BNL from SLAC National Accelerator Laboratory where she was associate lab director for fundamental physics and chief research officer. SLAC is operated by Stanford University in Menlo Park, California. In email responses, local female scientists suggested that Hewett’s hiring can and would inspire women in science, technology, engineering and math (STEM) fields.

“I am so delighted by the news that Dr. JoAnne Hewett has been named to be the next director of Brookhaven National Laboratory,” wrote Esther Takeuchi, William and Jane Knapp chair in Energy and the Environment and SUNY distinguished professor at Stony Brook University and chair of the Interdisciplinary Science Department at BNL. As the first female director for the lab, Hewett “is an inspiration not only for the women who are in the field, but for future female scientists who will witness first hand that success at the highest level.”

Stella Tsirka, SUNY distinguished professor in the Department of Pharmacological Sciences at the Renaissance School of Medicine at Stony Brook University, suggested this hire was a part of an increasing number of women in prominent positions in science at local institutions.

Stony Brook and BNL are “becoming a hub of strong female role models for younger females, in STEM, in medicine, in leadership!” Tsirka wrote. “Between [SB President] Maurie McInnis, Hewett, Ivet Bahar (the director of the Laufer Center), Anissa Abi-Dargham [principal investigator for the Long Island Network for Clinical and Translational Science] and many other successful female faculty in leadership positions, hopefully, the message comes out loud and clear to our young women who are in science already, or aspire to be in science.”

For her part, Abi-Dargham, who is chair in the Department of Psychiatry and Behavioral Health, described Hewett’s hire as “amazing” and suggested it was “really exciting to see an accomplished female scientist selected to head our collaborating institution at BNL!”

Cold Spring Harbor Laboratory Professor and Cancer Center Program co-leader Mikala Egeblad added that the significance of Hewett’s hire goes “well beyond inspiring young girls. It is important to have women leaders for all sciences, also for someone at my career stage. I hope that one day, we will get to a point when we don’t think about whether a leader is a woman or a man.”

Women remain underrepresented at top leadership positions, so Egeblad finds it “very inspiring to see a woman recognized for her leadership skills and selected” to head BNL.

Leemor Joshua-Tor, professor and HHMI investigator at CSHL, called the hire “really great news” and indicated this was “especially true for the physical sciences, where there are even fewer women in senior positions than in biology.” Joshua-Tor added that the more women in senior, visible positions, “the more young women and girls see this as a normal career to have.”

Alea Mills, professor and Cancer Center member at CSHL, wrote that it is “fantastic that BNL has found the very best scientist to lead them into their next new mission of success. And it’s an extra bonus that this top scientist happens to be a woman!”

Mills added that efforts to enhance diversity are fashionable currently, but all too often fall short. Hiring Hewett makes “real traction that will undoubtedly inspire future generations of young women in STEM.”

Patricia Wright, distinguished service professor at Stony Brook in the Department of Anthropology, wrote that it was “inspiring” to see a female director of BNL and that “young female scientists can aspire to being in that role some day.”

Braving the bugs, Alistair Rogers (right) and his colleague Stefanie Lasota collect leaf samples in Alaska for analysis. Photo by Roy Kaltschmidt

By Daniel Dunaief

Alistair Rogers lives, thinks and works on opposite extremes.

At the same time that he gathers information from the frigid Arctic, he is also analyzing data from the sweltering tropical forests of Panama and Brazil. He visits both regions annually and, within one eight-day span, saw a Polar Bear in Utqiaġvik (formerly known as Barrow), Alaska and a tarantula in Brazil.

Alistair Rogers. Photo from BNL

That’s not where the extremes end. Rogers is also studying plants at the physiological level to understand how best to represent processes such as photosynthesis, respiration and stomatal conductance in climate models.

The leader of the Terrestrial Ecosystem Science & Technology Group in the Environmental and Climate Sciences Department at Brookhaven National Laboratory, Rogers recently was honored as a Fellow of the American Association for the Advancement of Science.

The AAAS has named fellows every year since 1874 to recognize their contributions to the advancement of science. Previous honorees included astronaut and former Johnson Space Center Director Ellen Ochoa, a founding member of the NAACP and scholar W.E.B. Du Bois and inventor Thomas Edison.

Lisa Ainsworth, Research Leaders of the Global Change in Photosynthesis Unit for the USDA Research Service, nominated Rogers, who served as a mentor for her when she conducted her PhD research.

“[Rogers] is one of the world’s authorities on understanding how plants respond to atmospheric change and in particular rising carbon dioxide concentration,” Ainsworth said. He’s an experimentalist who “built a bridge to the scientific computational modeling community.”

Ainsworth suggested she would not have the career she developed if it weren’t for the support she received from Rogers.

Rogers, who the Department of Energy recognized as an Outstanding Mentor three times and has been at BNL since 1998, “makes you believe in yourself when you don’t have any reason to do that. He believes in you before you know you should believe in yourself,” Ainsworth said. For his part, Rogers is “delighted to be honored and recognized as a fellow.”

Carbon dioxide sinks

For all the extremes in his work, Rogers has been collecting data from plants to address a range of questions, including how they will react to and affect environmental changes caused by global warming.

Through photosynthesis, plants are responsible for absorbing about a third of the carbon dioxide humans produce through the burning of fossil fuels.

The uptake of carbon dioxide by plants and oceans has limited warming so far to 1.2 degrees Celsius above pre-Industrial temperatures. Without such carbon dioxide removal by oceans and plants, the temperature would already be 3 degrees warmer.

The models his work informs are trying to understand what will happen to the carbon dioxide subsidy in the future.

“In order to work out how warm it’s going to get, you need to know the carbon dioxide concentration and the climate sensitivity (how much warmer it will get for a given amount of carbon dioxide),” he explained in an email.

Photosynthesis is less efficient at higher temperatures, but is also more efficient amid an increased amount of carbon dioxide. Drier air also reduces the efficiency of the process as plants close their stomata to conserve water, which restricts carbon dioxide supply to their chloroplasts.

The transfer of water from land to the atmosphere most often occurs through stomata, so understanding the way these pores open and close is important in predicting cloud formation and other land-atmosphere interactions.

Ainsworth described how a typical day of field work gathering data could last for 16 hours. She appreciated how Rogers worked and played hard — he is a cyclist and a skier — while keeping the work fun. Indeed, Ainsworth said Rogers, on regular calls with two other professors, blends discussions about grants and work decisions with their first choice for their guesses at the New York Times wordle game.

Leadership roles

In addition to his leadership role at BNL, Rogers is also part of the leadership teams for the Next Generation Ecosystem Experiment — Arctic and the Next Generation Ecosystem Experiment —Tropics.

Rogers said the Arctic is seeing the biggest increase in temperature relative to anywhere else on the planet faster because of climate feedback. When ice and snow melt, it reveals surfaces that absorb more heat.

The tropics, meanwhile, have been more stable, although the region is expected to experience hotter, drier temperatures in the coming decades as well.

Alistair Rogers. Photo from BNL

The Department of Energy is studying these biomes because they are climatically sensitive, globally important and poorly represented in climate models.

Rogers is working with other scientists at BNL and around the world to understand these processes to feed his data collection and analysis into global models.

Using an analogy for developing these models, Rogers suggested trying to predict the time it would take to get to the airport. A traveler would need to know the distance and the mode of transport — whether she was walking, biking or riding in a car.

A model predicting the travel time would make assumptions about how fast a person could go in a car, while factoring in other data like the weather and traffic density at a particular time to anticipate the speed.

If the traffic model wasn’t sure of the maximum possible speed of a vehicle, the error associated with predicting the arrival time could be large, particularly when considering the difference between traveling in a steamroller or a Lamborghini on empty roads.

Climate models use a similar process. By studying the species of plants, Rogers can tell the models whether the plants are the equivalent of sports cars or steamrollers.

Big picture

The worst case scenario of earlier models is highly unlikely, although the scenario of a drastic reduction in carbon dioxide also hasn’t occurred. The models, however, still suggest that changes in human behavior are critical to protecting the future of the planet against the effects of climate change.

Rogers is encouraged by the declining cost of solar energy and the work developing countries have done to bypass some of the more polluting sources of energy from the industrial revolution. He is also pleased by the commitment from the Department of Energy to look for climate change solutions.

These elements “represent great opportunities for scientists like me” to work on these problems.

Hunter College Campus Schools and Ward Melville High School took the top spots in the Long Island Regional Science Bowl competitions hosted by the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory on Feb. 2 and Feb. 3. The fast-paced question-and-answer contest quizzed students on chemistry, biology, physics, mathematics, astronomy, and general, earth, and computer science.

Science Bowl alumni Suraj Muralidharan, Stephanie Zhang, and Amanda Chen volunteered at the 2023 competitions.

This year, the regional middle and high school events returned to an in-person, head-to-head tournament at the Laboratory after going virtual for two years due to the COVID-19 pandemic. About 80 volunteers including BNL staff, community members, and past Science Bowl participants helped out this year.

“Brookhaven’s Office of Educational Programs was so excited to welcome students back onsite for a full day of competition and science learning,” said Amanda Horn, a Brookhaven Lab educator who coordinated the events. “This competition provides students with a unique opportunity to show off their science skills and knowledge, and learn about the Lab as well as the DOE.”

Hunter College and Ward Melville’s first place wins in the middle school and high school competitions, respectively, secured each team an all-expenses paid trip to compete at DOE’s National Science Bowl finals scheduled for April 27 to May 1 in Washington, D.C.

The DOE created the National Science Bowl in 1991 to encourage students to excel in mathematics and science and to pursue careers in these fields. Approximately 330,000 students have participated in the National Science Bowl® throughout its 32-year history, and it is one of the nation’s largest science competitions.

“The National Science Bowl® is an extraordinary competition that brings together young minds across America through science and technology,” said Asmeret Asefaw Berhe, DOE Office of Science Director, “and I would like to congratulate the Hunter College Campus Middle School and Ward Melville High School teams as they advance to the National Finals! Good luck to you — our future scientists, visionaries, and leaders!”

Middle School Science Bowl Results

First Place: The regional middle school event held on Feb. 2 was open to teams from New York City schools in addition to schools on Long Island. Under the guidance of coaches Jennifer Kasanuki and Christopher Torpey, a team from Hunter College Campus Schools of NYC — Kieran Torpey, Gabriel Fang, Max Levin, Andres Fischer and Camille Pimentel — earned a back-to-back win for their school after being tied halfway through the final round against R.C. Murphy Junior High School of Stony Brook.

“It feels really great,” said Hunter College team captain and eighth grader Kieran Torpey. “We’ve studied really hard for this. I love science and to know a lot of science is really great.”

Second Place: R.C. Murphy Junior High School — Harry Gao, Gabrielle Wong, Menghan Tang, Willem Van der Velden, Kayla Harte (Coaches: Jillian Visser and Emily Chernakoff)

Third Place: John F. Kennedy Middle School Team 1 — Chaeten Modgil, Maya Swierupski, Jayden Brun, Aiden Karp, Ryan Perovich (Coach: Steven Nielsen)

Fourth Place: NYC Lab Middle School for Collaborative Studies Team 1 — Ryan Casey, Jonathan Lin, Vince Liao, Kolbi Canell, Daniel Berkovich (Coaches: Faithe Theresa Yates and Eva Deffenbaugh)

High School Science Bowl Results

First Place: Competing against 23 other teams, Ward Melville High School of East Setauket secured their first-place win in a second-round showdown against Great Neck South High School on Feb. 3. 

Under the guidance of Coach Philip Medina, team members — Benjamin Proothi, Rithik Sogal, Anna Xing, Benjamin Zhang and Michael Melikyan — went undefeated in their first four round robin matches and reached the double-elimination finals where they faced a team from Great Neck. 

Great Neck gave them their first lost, but Ward Melville High School pulled through during the tiebreaker round where they surged ahead with a rally of several questions and bonus points — an intense, yet exciting way to win.

“We didn’t really know exactly what the score was,” said Ben Proothi. “We just felt like we were ahead by a little bit, so we took the chance and ran out the clock.”

“It’s incredible,” said team captain and junior Michael Melikyan. “We’ve always been fighting Great Neck South for a top spot, and they’ve always been taking it. They always have a strong team and incredible people and we’re just happy we finally managed to pull through. We’re very grateful and very proud to be going [to the National Science Bowl].” 

This marks the first time in six years Ward Melville High School has qualified for the national tournament. “They’re an amazing group of people. I have no idea how they know this stuff, it’s incredible. They were working so well under pressure. I’m very proud of them,” added Coach Medina.

Second Place: Great Neck South High School — Richard Zhuang, Laura Zhang, Brandon Kim, Eric Pei, Erin Wong (Coaches: James Truglio and Nicole Spinelli)

Third Place: Farmingdale Senior High School — Waseem Ahmad, Ali Ahmad, Madhav Rapelli, Bevis Jiang, Rayan Adamjee, (Coach: Ashley Arroyo)

Fourth Place: Jericho Senior High School — Derek Minn, Natasha Kulviwat, He Xuan, Ashwin Narayanan, Brendan Shek (Coaches: Samantha Sforza and Emily Umile)

—————————————–

Brookhaven Lab’s Office of Educational Programs (OEP) organized science fun for students throughout both competition days with a STEM Expo, tour, and additional science challenge. Staff and visiting students offered hands-on science demonstrations that included a cloud chamber that revealed electron tracks, sound and light sensitive microcontrollers, tricky engineering attempts, and robotic building blocks.

Science Bowl teams that did not move on to the competitions’ final double elimination rounds had the chance to get an up-close look at the STAR detector at the Relativistic Heavy Ion Collider (RHIC), a DOE Office of Science User Facility for nuclear physics research. STAR, which weighs 1,200 tons and is as large as a house, tracks thousands of particles produced by ion collisions at RHIC to uncover clues about the universe in the moments after the Big Bang.

Teams also competed in a STEM Challenge, racing against the clock and each other to solve science and math puzzles to break several locks on boxes filled with treats. Among participating middle schools, Elmont Memorial High School earned first place, Sayville Middle School took second, and Great Neck South Team 1 placed third.

Long Beach High School completed the STEM Challenge first among participating high schools, followed by General Douglas Macarthur Senior High School, then Lynbrook Senior High School. Long Beach student Sam Adler used the periodic table to crack the code for one of the team’s final locks.

“It was so much fun,” Adler said. “I was so stressed during the competition itself and this was all good fun.”

For more information, visit www.bnl.gov.

Luisella Lari. Photo from BNL

By Daniel Dunaief

Some day, physicists and members of the public who benefit from their discoveries may be happy that Luisella Lari had limited musical and sports talent.

Lari, who grew up in Torino, Italy, tried numerous sports and instruments, especially with her parents’ encouragement.

Luisella Lari studies continuous feature drawings of the Electron Ion Collider. Photo from BNL

After gamely trying, Lari blazed her own trail, which has led her to become Project Manager and senior scientist for the Electron Ion Collider, a one-of-a-kind nuclear physics research facility at Brookhaven National Laboratory. BNL won the rights to construct the EIC, which the lab will plan and develop over the course of the next decade, from the Department of Energy in 2020.

By using a 2.4 mile circumference particle collider, physicists will collide polarized electrons into ions with polarized protons to answer a host of questions about the nature of matter. They will gather information about the basic building blocks of nuclei and how quarks and gluons, the particles inside neutrons and protons, interact dynamically through the strong force to generate the fundamental properties of these particles, such as mass and spin.

Lari, who joined the EIC effort on October 3rd, described her role, which includes numerous meetings, calls and coordinating with multinational and multi-state teams, as a “dream job.”

“I’m so excited to be a part of a project that can help the next generation of physicists,” Lari said. “It’s my turn to participate in the construction” of the cutting edge facility. BNL is coordinating with numerous other labs nationally, including the Thomas Jefferson National Accelerator in Virginia, an internationally on the project.

Amid her numerous responsibilities, Lari will ensure that effective project management systems, cost controls and project schedules are developed, documented and implemented. Core competencies of the team she is responsible for include procurement, quality and safety.

EIC applications

The EIC has numerous potential applications across a host of fields. It could lead to energy-efficient accelerators, which could lower the cost of accelerators to make and test computer chips. The EIC could also provide energetic particles that can treat caner cells and improve the design of solar cells, batteries and catalysts. The EIC may also help develop new kinds of drugs and other medical treatments.

Lari explained that she provides a review and approval of the safety evaluations performed by experts. She suggested this suits her background as she did similar work earlier in her career.

Luisella Lari on a recent vacation to Mackinac Island.

Lari has made it a priority to hire a diversified workforce of engineers, technicians and quality and safety managers who can contribute to a project that BNL will likely start constructing in 2026 and 2027.

“I am a strong supporter of building a diverse workforce at levels of the organization,” she explained in an email. “I am strongly convinced that it will add value to any work environment and in particular in a scientific community.”

Applying her experience

Lari isn’t just an administrator and a project coordinator —  she is also a physicist by training.

She earned a master’s degree in nuclear engineering from Politecnico di Torino University in Italy and a PhD in physics from the Swiss Federal Institute of Technology Lausanne in Switzerland.

Early in her professional career, Lari worked at Thales Alenia Space, an aerospace company in Turin, Italy, where she collaborated for the development of her master’s thesis. She worked for two years at the company, performing tasks that included testing internal fluid supply lines for one of the International Space Station’s pressurized modules that connects the United States, European and Japanese laboratories in orbit.

She enjoyed the opportunity to work for a “really interesting project” and still routinely uses the NASA system engineering handbook.

She also worked for about a dozen years as an applied physicist and planning officer at CERN, a particle physics lab, which is on the border between France and Switzerland near Geneva.

Lari also served as a project manager and scientist for the European Spallation Source, a neutron source under construction in Sweden. She coordinated ESS Accelerator Project budgets and ran data-driven safety analyses.

Recently, Lari was a senior manager at Fermi National Accelerator in Illinois, where she coordinated international partner contributions to the Proton Improvement Plan II, which upgraded the accelerator complex.

A need to know

When Lari was in middle school, the Chernobyl nuclear power plant melted down. As a school assignment, she had to explain what happened. At that point, she said she understood nothing, which motivated her to want to become a nuclear engineer.

She was “fascinated by nuclear energy.” When she worked at CERN, she had not been studied much about accelerator physics. She attended meetings where sophisticated discussions physics took place and was driven to learn the material.

“All my life, which started when I was a child, I wanted to understand the world around me,” she said. Her work in project management for scientific projects is also her passion, she said. “My mother would say to me when I was younger that I should choose my job in a way that I would do something I like, because I will spend half my life doing it.”

In addition to committing to understanding the physics and helping other scientists pursue their curiosity, Lari said she appreciates the opportunity to collaborate.

While Lari never became proficient in music or athletics, she enjoys dancing and is looking forward to attending Broadway musicals in New York.

She has hosted her parents at each of the places where she has worked, broadening their horizons.

As for her work, Lari recalls being impressed by the ability of the managers at the LHC to summarize complex work in a few pages and to make big picture decisions that affected so many other scientists. She became impressed and inspired “by the power of the project administrator approach,” she said. She also appreciates the opportunities to interact with experts in several fields, which gives her the chance to “better understand and learn.”

Commemorating the start of construction for the Science and User Support Center from the U.S. Department of Energy and Brookhaven Lab are (from left) Joe Diehl, Caroline Polanish, Robert Gordon, Geri Richmond, Doon Gibbs, Chris Ogeka, Tom Daniels, Peggy Caradonna, Andrea Clemente, and Gary Olson. Photo from BNL

Construction is underway for the newest facility at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory. The Science and User Support Center (SUSC) is the first building for the planned Discovery Park, a development the Laboratory is pursuing near its entrance along William Floyd Parkway.

The three-story, 75,000-square-foot facility will serve as a welcome center for the 75-year-old Brookhaven Lab, which is home to seven Nobel Prize-winning discoveries and hosts thousands of guests annually. The SUSC will also offer conference and collaboration areas for scientists as well as office space for the Lab‘s support staff.

Officials from DOE and Brookhaven Lab commemorated the start of construction during a groundbreaking ceremony Wednesday, Oct. 26.

DOE’s Under Secretary of Science and Innovation Geri Richmond said, “This strategy—of welcoming the community to be part to our nationallaboratories and focusing on creative, innovative ways for public-private partnerships to strengthen the economy—is so important. This is a centerpiece, a catalyst for the campus and for the future.”

Manager of DOE’s local Brookhaven Site Office, Robert Gordon, said, “This is transformative for Brookhaven National Laboratory. We should be accessible. We’ve done that with our words and our actions. Now we’re doing it with concrete.”

Brookhaven Lab Director Doon Gibbs said, “This construction is a milestone in the Laboratory‘s long-term strategy to revitalize its physical plant. We look forward to welcoming visitors, users, students, and members of the community to connect with Brookhaven, the DOE, our science, and the impact it has.”

Plainview-based E.W. Howell is leading construction as the project’s general contractor. The Laboratory announced in February that it awarded E.W. Howell a $61.8 million contract to build the SUSC. DOE approved a total cost of $86.2 million for the project. E.W. Howell and BrookhavenLab are targeting 2024 for construction to be completed.

The SUSC is the first building planned for Discovery Park, a new vision for Brookhaven Lab‘s gateway with approximately 60 acres of previously used, publicly accessible land. The Laboratory is working with DOE on a process for developers, collaborators, and entrepreneurs to propose, build, and operate new facilities that could complement DOE and Brookhaven Lab‘s missions and leverage opportunities from close proximity to the Laboratory.

Empire State Development is supporting Brookhaven Lab‘s efforts for Discovery Park with a $1.8 million capital grant, recommended by the Long Island Regional Economic Development Council.

The future Science and User Support Center. Rendering courtesy of BNL

Increasing Efficiency for Discoveries, New Technology

Brookhaven Lab attracts scientists from across the country and around the world by offering expertise and access to large user facilities with unique capabilities.

Brookhaven hosted more than 4,400 in-person and virtual scientists from universities, private industry, and government agencies in fiscal year 2021. In the years before the COVID-19 pandemic, more than 5,000 guests and facility users visited each year. The Laboratory expects the number of guests researchers to increase in the coming years, particularly as capabilities expand at the National Synchrotron Light Source II—a DOE Office of Science User Facility—and with the design and construction of the future Electron-Ion Collider.

The SUSC, when complete, is where those guests will arrive. The SUSC will also help improve the guests’ experiences of visiting Brookhavenbecause the Laboratory will consolidate a number of guest services into a central, modern building close to the site entrance.

The SUSC will also feature reconfigurable conference space, designed in response to requests from facility user communities to create opportunities for scientists to collaborate.

In addition, the SUSC will help the Laboratory increase efficiencies by reducing its building footprint atop the 5,322-acre site. The Laboratory plans to relocate approximately 225 staff at the SUSC. They are currently spread across the Lab site, which contains 314 buildings—some that date back to the World War II era, when the Laboratory was the site of the Army’s former Camp Upton.

The SUSC project is funded by the DOE Office of Science.

Brookhaven National Laboratory is supported by the Office of Science of the U.S. Department of Energy. The Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time. For more information, visit science.energy.gov.

Mercy Baez. Photo by Joseph Rubino/ BNL

By Daniel Dunaief

She is a greeter, a corporate concierge, a facilitator, a point of contact for people traveling thousands of miles, a Spanish translator, an important contact in case of emergencies, and whatever else visitors need.

While Mercy Baez, who was promoted to User Program Coordinator for the National Synchrotron Lightsource II and the Laboratory for BioMolecular Structure at Brookhaven National Laboratory early in October, wears many hats, one of the only ones she doesn’t wear is scientist, although that doesn’t keep her from appreciating and taking pride in the research conducted at the Department of Energy facility.

“We’re helping them and they are helping the world,” Baez said.

BNL has a steady stream of users who apply for time at the various research facilities at the national laboratories. 

Baez is specifically responsible for providing a wide range of support and services to the NSLS II and the LBMS. Users, which is how BNL describes potential visiting scientists who conduct research at the lab’s facilities, submit proposals to her office, which then distributes them to a proposal review panel.

When visiting scientists learn that their work, which includes monitoring batteries as they function and searching for fine structural sites in the molecular battle against pathogens, has earned a high enough score to receive coveted time on the lab’s instruments, they prepare for their visit by interacting with Baez and her current team of four by getting registered and approved for access.

Baez offers soup to nuts guidance that often also includes helping users literally find soup, nuts and numerous other items. Baez ensures that users take any necessary training courses, provides guidance regarding registering for on site access to BNL, provides information on the steps or items necessary when they arrive, helps find nearby hotels, coordinate travel to and from the lab and, if necessary, secures places to stay if they miss their planes, get snowed in or have other unforeseen changes in their schedules.

As of October 1st, visitors also have to have some type of active shooter training to access the lab’s facilities. Currently, users are required to take five training courses. Last week, the lab decided to incorporate active shooter training into one of these other training courses.

The lab has always had routine emergency training courses and drills for lab employees. With the changing times and current events, the lab is looking to equip users for such emergencies. The lab hopes never to have to use this training, but if such an event occurs, staff and users will know how to handle such a situation.

In addition to training to help users prepare to visit the facility, Baez provides visitors with a host of on site facilities, including adaptors in case they are using European electronics that don’t connect with the outlets, laptops in case the computer a scientist brought isn’t working, conference rooms for impromptu meetings, and dorm rooms for a respite while running time-intensive experiments.

BNL hosts employee resource groups including the African American Advancement Group, the Asian Pacific American Association, the Brookhaven Veterans Association, Brookhaven Women in Science, the Early Career Resource Group, the Pride Alliance and the Hispanic Heritage Group. Baez said the lab tries to involve users and visitors in as many cultural and social events as possible, which include outings to dinners, plays and cultural virtual cooking classes.

In September, Baez participated in the Port Jefferson Dragon Boat Race Festival which the Asian Pacific  American Association sponsored. 

Baez, whose mother is from Puerto Rico and whose father is from Ecuador, is a member of the Hispanic Heritage Group.

A people person

A member of the user offices since 2003, Baez had recently been responsible for coordinating conferences, workshops, and training courses, including financial and logistical aspects of the events for NSLS-II and the LBMS. She had been functioning as the user program coordinator since January, when Gretchen Cisco retired. Baez feels fortunate to have worked with Cisco since she joined NSLS in 2005.

A self-described “people person,” Baez said she loves the opportunity to interact with scientists from all over the world. She particularly appreciates the chance to get to know about other cultures and has added destinations to her travel itinerary from speaking with visitors. She is hoping to travel to Morocco and Peru next year and is hoping to travel to Japan and a few other countries in the near future.

Coming from a Latina family that tends to be loud and outspoken and whose family gatherings often includes more than 30 people, she has learned to speak in a softer voice, particularly with people from other cultures or backgrounds.

She also has a tendency to speak quickly and has learned to slow the pace down so visitors who haven’t interacted with her can understand what she’s saying.

A resident of Medford, which is a ten-minute drive from the lab, Baez has a son Xzavier and a granddaughter Francesca. She is excited for the upcoming arrival of her second granddaughter in November.

When she’s not at the lab, she uses her leisure time to go hiking, fishing and camping.

With her then teenage son in tow, she went to the jungle of Belize for a survival course, where they learned how to catch their own food, build shelters, and harpoon fish. She also learned which plants are safe to eat and which are poisonous.

While her work responsibilities can be hair-raising, particularly in emergencies, she “loves the feeling that I was able to help a scientist, whether to get him or her on site or in an emergency,” she said. Knowing that she’s a part of making all this science happen makes her day and job rewarding, she said.

Baez has had some requests from scientists who have wanted cultural foods, such as Turkish or vegan dishes, that might be harder to find, particularly during off hours.

Around Thanksgiving each year, some visitors have asked if they can hunt wild turkeys at BNL, which is located within the Pine Barrens and has turkeys and deer wandering on site. She has told those users that the lab does not allow hunting.

Hunting aside, Baez said she is “here to help [users] do what they need to do.”

Duckweed. Photo from BNL
Scientists drive oil accumulation in rapidly growing aquatic plants

Scientists at the U.S. Department of Energy’s Brookhaven National Laboratory and collaborators at Cold Spring Harbor Laboratory (CSHL) have engineered duckweed to produce high yields of oil. The team added genes to one of nature’s fastest growing aquatic plants to “push” the synthesis of fatty acids, “pull” those fatty acids into oils, and “protect” the oil from degradation. As the scientists explain in a paper published in Plant Biotechnology Journal, such oil-rich duckweed could be easily harvested to produce biofuels or other bioproducts.

John Shanklin. Photo from BNL

The paper describes how the scientists engineered a strain of duckweed, Lemna japonica, to accumulate oil at close to 10 percent of its dry weight biomass. That’s a dramatic, 100-fold increase over such plants growing in the wild—with yields more than seven times higher than soybeans, today’s largest source of biodiesel.

“Duckweed grows fast,” said Brookhaven Lab biochemist John Shanklin [https://www.bnl.gov/staff/shanklin], who led the team. “It has only tiny stems and roots—so most of its biomass is in leaf-like fronds that grow on the surface of ponds worldwide. Our engineering creates high oil content in all that biomass.

“Growing and harvesting this engineered duckweed in batches and extracting its oil could be an efficient pathway to renewable and sustainable oil production,” he said.

Two added benefits: As an aquatic plant, oil-producing duckweed wouldn’t compete with food crops for prime agricultural land. It can even grow on runoff from pig and poultry farms.

“That means this engineered plant could potentially clean up agricultural waste streams as it produces oil,” Shanklin said.

Leveraging two Long Island research institutions

The current project has roots in Brookhaven Lab research on duckweeds from the 1970s, led by William S. Hillman in the Biology Department. Later, other members of the Biology Department worked with the Martienssen group at Cold Spring Harbor to develop a highly efficient method for expressing genes from other species in duckweeds, along with approaches to suppress expression of duckweeds’ own genes, as desired.

As Brookhaven researchers led by Shanklin and Jorg Schwender [https://www.bnl.gov/staff/schwend] over the past two decades identified the key biochemical factors that drive oil production and accumulation in plants, one goal was to leverage that knowledge and the genetic tools to try to modify plant oil production. The latest research, reported here, tested this approach by engineering duckweed with the genes that control these oil-production factors to study their combined effects.

“The current project brings together Brookhaven Lab’s expertise in the biochemistry and regulation of plant oil biosynthesis with Cold Spring Harbor’s cutting-edge genomics and genetics capabilities,” Shanklin said.

One of the oil-production genes identified by the Brookhaven researchers pushes the production of the basic building blocks of oil, known as fatty acids. Another pulls, or assembles, those fatty acids into molecules called triacylglycerols (TAG)—combinations of three fatty acids that link up to form the hydrocarbons we call oils. The third gene produces a protein that coats oil droplets in plant tissues, protecting them from degradation.

From preliminary work, the scientists found that increased fatty acid levels triggered by the “push” gene can have detrimental effects on plant growth. To avoid those effects, Brookhaven Lab postdoctoral researcher Yuanxue Liang paired that gene with a promoter that can be turned on by the addition of a tiny amount of a specific chemical inducer.

“Adding this promoter keeps the push gene turned off until we add the inducer, which allows the plants to grow normally before we turn on fatty acid/oil production,” Shanklin said.

Liang then created a series of gene combinations to express the improved push, pull, and protect factors singly, in pairs, and all together. In the paper these are abbreviated as W, D, and O for their biochemical/genetic names, where W=push, D=pull, and O=protect.

The key findings

Overexpression of each gene modification alone did not significantly increase fatty acid levels in Lemna japonica fronds. But plants engineered with all three modifications accumulated up to 16 percent of their dry weight as fatty acids and 8.7 percent as oil when results were averaged across several different transgenic lines. The best plants accumulated up to 10 percent TAG—more than 100 times the level of oil that accumulates in unmodified wild type plants.

Some combinations of two modifications (WD and DO) increased fatty acid content and TAG accumulation dramatically relative to their individual effects. These results are called synergistic, where the combined effect of two genes increased production more than the sum of the two separate modifications.

These results were also revealed in images of lipid droplets in the plants’ fronds, produced using a confocal microscope at the Center for Functional Nanomaterials [https://www.bnl.gov/cfn/] (CFN), a DOE Office of Science user facility at Brookhaven Lab. When the duckweed fronds were stained with a chemical that binds to oil, the images showed that plants with each two-gene combination (OD, OW, WD) had enhanced accumulation of lipid droplets relative to plants where these genes were expressed singly—and also when compared to control plants with no genetic modification. Plants from the OD and OWD lines both had large oil droplets, but the OWD line had more of them, producing the strongest signals.

“Future work will focus on testing push, pull, and protect factors from a variety of different sources, optimizing the levels of expression of the three oil-inducing genes, and refining the timing of their expression,” Shanklin said. “Beyond that we are working on how to scale up production from laboratory to industrial levels.”

That scale-up work has several main thrusts: 1) designing the types of large-scale culture vessels for growing the modified plants, 2) optimizing large-scale growth conditions, and 3) developing methods to efficiently extract oil at high levels.

This work was funded by the DOE Office of Science (BER). CFN is also supported by the Office of Science (BES).

Brookhaven National Laboratory is supported by the Office of Science of the U.S. Department of Energy. The Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time. For more information, visit science.energy.gov. [https://www.energy.gov/science/]

Dr. John Clarke. Photo from BNL

By Daniel Dunaief

Live from Upton, New York, it’s … Dr. John Clarke.

While the arrival of the new Occupational Medicine Director and Chief Medical Officer at Brookhaven National Laboratory doesn’t involve late-night comedy, or a live studio audience, it does bring a medical doctor with a passion for bringing his rap and musical skills to a health care audience.

Dr. John Clarke. Photo from BN

Formerly the director of occupational medicine at Cornell University, Dr. Clarke joined the Department of Energy lab as Occupational Medicine Director and Chief Medical Officer for BNL in June..

“My role is to help maintain safety and wellness among the workers,” said Dr. Clarke. “If we have employees who start coming in for some sort of complaint and we see a pattern, that may help us identify who could be at risk of something we didn’t know about that we are detecting.”

A doctor who served as chief resident at New York Medical College in family residency and Harvard University in occupational & environmental medicine, Dr. Clarke said he plans to support a range of preventive efforts.

“I’m excited about the potential to engage in what’s considered primary prevention,” said Clarke, which he defined as preventing a disease from occurring in the first place.

Through primary prevention, he hopes to help the staff avoid developing chronic illnesses such as cancer, while also ensuring the health and responsiveness of their immune systems.

Through physical fitness, a plant-based diet including fruits and vegetables, adequate sleep and hydration with water, people can use lifestyle choices and habits to reduce their need for various medications and enable them to harness the ability of their immune systems to mount an effective response against any threat.

“Modifying your lifestyle is the therapy,” he said. “If you engage [in those activities] in the right way, that is the treatment.”

Dr. Clarke added that the severity and stage of a disease may impact the effectiveness of such efforts. For any vaccine and for the body’s natural immunity to work, people need a healthy immune system.

When Dr. Clarke practiced family medicine, he saw how patients lost weight through a diet that reduced the need for medication for diabetes and high blood pressure.

“Losing weight and staying active does provide a therapeutic impact, where you could be medication free,” he said.

To be sure, living a healthier lifestyle requires ongoing effort to maintain. After reaching a desired weight or cholesterol level, people can backslide into an unhealthier state or condition, triggering the occurrence or recurrence of a disease.

In the vast majority of cases, Clarke said, “you have to make a permanent lifestyle change” to avoid the need for pharmaceutical remedies that reduce the worst effects of disease.

BNL has an exercise physiologist on staff who “we hope to engage in consultations with employees,” said Clarke. He would like the exercise physiologist to go to the gym with staff to show them how to use equipment properly to get the maximum benefit.

BNL already has some classes and various initiatives that promote wellness. “One of the things we’d like to do is coordinate and try to publicize it enough where employees are aware” of the options available at the lab to live a healthier and balanced life, he added.

BNL also has a dietician on staff. Dr. Clarke has not worked with the dietician yet, but hopes it will be part of an upcoming initiative. As he and his staff respond to the demand, they will consider bringing on other consultants and experts to develop programs. 

Covid concerns

Like others in his position in other large employers around Long Island, Dr. Clarke is focused on protecting workers from any ongoing threat from Covid-19.

“We’re still learning more as [SARS-CoV2, the virus that caused the pandemic] evolves,” he said. BNL does a “great job about monitoring the prevalence and the numbers of cases in Suffolk County and among workers.”

Dr. Clarke said he and others at BNL are following the Department of Energy, New York State and Centers for Disease Control and Prevention guidance on these issues.

If the numbers of infections and hospitalizations increase in the coming months, as people move to more indoor activities, BNL may consider deploying a strategy where the lab provides more opportunities for staff to work remotely.

Prior to his arrival at BNL, Dr. Clarke worked as a consultant for a company that was looking to create numerous permanent jobs that were remote.

He suggested that workers need to remain aware of their remote surroundings and shouldn’t work near a furnace or any heater that might release dangerous gases like carbon monoxide. 

Additionally, people should avoid working in areas that aren’t habitable, such as in an attic. Dr. Clarke urges people to notify and consult their employer if they have concerns about working safely at home or on site.

Music vs. medicine

A native of Queens who spent three years of his childhood in Barbados, Dr. Clarke attended Columbia University, where he majored in sociology and music while he was on a pre-med track.

While he was an undergraduate, Dr. Clarke wrote, produced and performed original music. An independent label was going to help secure a major label deal.

He chose to attend medical school at Icahn School of Medicine at Mount Sinai.

Dr. Clarke has championed a program he calls “health hop,” in which he has used rap to reach various audiences with medical care messages. In 2009, he won a flu prevention video contest sponsored by the Department of Health and Human Services for an “H1N1 rap.”

Train commuters may also recognize him from his work for the Long Island Railroad, for which he created a “gap rap.” The public service announcement was designed to protect children from falling into or tripping over the gap between the train and the platform.

Dr. Clarke has produced music for numerous genres, including for a children’s album and a Christian album.

As for life outside BNL, Dr. Clarke is married to Elizabeth Clarke, who is a nurse practitioner and is in the doctorate of nursing practice and clinical leadership program at Duke University.

When he’s not spending time with his wife or their children, he enjoys home projects like flooring and tiling.

Dr. Clarke is pleased to be working at the national Department of Energy lab.“BNL is a great place, because the science and the work they do has an impact,” he said.

Babak Andi holds a 3-D model of the coronavirus responsible for the COVID-19 pandemic. Photo courtesy of BNL

By Daniel Dunaief

For close to two and a half years, the world has had a microbial enemy. The SARS-CoV2 virus, which causes Covid-19, has resulted in close to 6.5 million deaths, caused lockdowns, restricted travel, closed businesses, and sickened millions. The key to fighting such a dangerous enemy lies in learning more about it and defeating its battle plan.

Working with principal investigator Daniel Keedy, Assistant Professor at the City University of New York and Diamond Light Source in the United Kingdom, Babak Andi, who is a beamline scientist from the structural biology group at Brookhaven National Laboratory, spent over two years studying a key viral enzyme.

Recently, the researchers revealed the structure at five temperatures of an enzyme called Mpro, for main protease. This enzyme, which separates proteins the virus makes, is critical for the maturation of the SARS-CoV-2 virus particles. They published their work in the Journal of the International Union of Crystallography (IUCrJ).

Using the Frontier Macromolecular Crystallography (FMX) beamline at the National Synchrotron Light Source II at BNL, Andi collected data on the structure of the enzyme at temperatures ranging from 100 degrees Kelvin, which is about negative 280 degrees Fahrenheit, all the way up to 310 degrees Kelvin, which is normal body temperature. “Nobody had done that, specifically for this protein,” said Andi.

Keedy, who guided the data collection, processed the information and wrote most of the paper, described the effort as a “great collaboration.” The gradual change in the conformation of the enzyme helped the scientists learn how it may move or shape-shift in general, he explained.

Keedy had worked with BNL in the past and pursued research at the FMX beamline because the scientists at BNL had “been working with Mpro on site, and were very approachable and open to the idea.”

Finding the specific structure of important proteins like Mpro can help researchers, pharmaceutical companies and doctors search for inhibitors or small molecules that could be specific to these proteins and that might interfere with their function.

Andi and other scientists at this beamline worked through the pandemic shutdown because of the potential practical application of what they were doing.

“We almost had all the infrastructures in place to allow other scientists to connect and operate the beamlines remotely, enabling them to collect data on Covid-19 virus proteins,” said Andi. “In my opinion, being able to support all the academic and industrial scientists to collect data for Covid-19 research was our greatest achievement during the worst period of the pandemic.”

While coming into the lab in those early months raised concerns about their own health, Andi and his colleagues, who developed safety protocols, felt an urgency to conduct this research.

“When Covid hit, we had a sense that this is our duty, this is our job to contribute to this field, to make sure that every scientist who works on Covid-19 had easy access to our beamlines, facilities and all the tools [necessary] to make new drugs,” said Andi. 

How they solved the structure

The technology for the beamline enables Andi and other scientists to collect data quickly and even remotely. Speed helps because the longer x-rays hit a protein, the more likely they are to cause the kind of damage that makes determining the structure difficult, particularly at higher temperatures.

The first step in this research was in producing this protein, which Andi’s collaborators at BNL in the biology department provided. The biology department also helped with crystallization.

Andi prepared the beamline and aligned the x-ray beam, which are necessary to collect data.

The scientists rotated and moved the crystal through the x-ray, distributing the beam over the length of the crystal to minimize radiation damage.

The small size of the x-ray beam made it possible to keep the beam focused on the smallest dimension of the structure. The researchers studied the crystal at five different temperatures, starting at cryogenic all the way up to physiological.

Of the 195,000 structures listed in the Protein Data Bank, or PDB, only five had been determined at body temperature. That includes two from the group of collaborators who participated in this study.

Andi collected three or four data sets at each temperature.

“The different conformations we saw may inspire a new twist on antiviral drug development that targets a different place in the protein, but with a similar or better effect,” Keedy explained.

The researchers did not include other factors that might affect the conformation of the protein, such as pH, pressure, the number of ions or salts in the environment, among others. For the Mpro protease to work, it has to bond to another similar protein, forming a dimer.

Andi said the Pfizer treatment Paxlovid binds to the active site of this enzyme, inactivating it.

The drugs he is looking for are similar, although he is also searching for other places on the enzyme besides its active site.

Keedy hopes to try to make a monomeric form of the enzyme through a mutation. He could then find drug-like small molecules that target the exposed interface between the two copies.

BNL origins

After he completed his PhD and post doctoral work at the University of Oklahoma, Andi started his career at BNL 11 years ago as a post doctoral researcher.

During his childhood, Andi was initially interested in astronomy. When he enrolled at a university outside the United States, he took an entrance exam.

“Based on your score, it tells you which discipline of science you can go into,” he said. His score directed him to the field of cell and molecular biology.

“I’m happy this happened,” he said. “I find that I’m actually more interested in molecular biology than in astronomy.”

Outside of work, Andi enjoys do-it-yourself projects. Astronomy also continues to appeal to him, as he is fascinated with astrophotography and reads astronomy articles.

As for the work with a Covid enzyme, Andi hopes he has other opportunities to contribute. 

“I am interested [in continuing] the research in this field,” he explained. “That depends on time, resources and current or future priorities.”

Katia Lamer during her experiment in Houston. Photo courtesy of U.S. Department of Energy Atmospheric Radiation Measurement user facility

By Daniel Dunaief

Clouds and rain often cause people to cancel their plans and seek alternative activities.

The opposite was the case for Katia Lamer this summer. A scientist and Director of Operations of Brookhaven National Laboratory’s Center for Multiscale Applied Sensing, Lamer was in Houston to participate in ESCAPE and TRACER studies to understand the impact of pollution on deep convective cloud formation. 

Katia Lamer during her experiment in Houston. Photo courtesy of U.S. Department of Energy Atmospheric Radiation Measurement user facility

With uncharacteristically dry weather and fewer of the clouds she and others intended to study, she had some down time and created a plan to study the distribution of urban heat. “I am always looking for an opportunity to grow the Center for Multiscale Applied Sensing and try to make the best of every situation,” she said.

Indeed, Lamer and her team launched 32 small, helium-filled party balloons. She and Stony Brook University student Zachary Mages each released 16 balloons every 100 meters while walking a one mile transect from the suburbs to downtown Houston. A mobile observatory followed the balloons and gathered data in real time through a radio link. 

While helium-filled party balloons are not the best option, Lamer said the greater good lay in gathering the kind of data that will be helpful in measuring and monitoring climate change and explained that until some better balloon technology was available, this is what they had to use.

“Typically, we launch the giant radiosonde balloons, but you can’t launch them in a city,” she said because of the lack of space for these larger balloons to rise without hitting obstacles. The balloons also might pass through navigable airspace, disturbing flight traffic.

The smaller party balloons carried sensitive equipment that measured temperature and humidity and had a GPS sensor tucked into foam cups.

“If we can demonstrate that there is significant variability in the vertical distribution of temperature and humidity at those scales, then this would suggest that we should push to increase the resolution of our models to improve climate change projections,” she explained.

By following these balloons closely with a mobile observatory, Lamer and her team can avoid interference from other signals and signal blockage by buildings.

The system they used allowed them to select a cut-off height. Once the balloons reached that altitude, the string that connected the sensors to the balloon burns off and the sensors start free-falling while the balloon climbs until it pops.

The sensors collect continuous data on temperature, humidity and horizontal wind during the ascent and descent. Using the GPS, researchers can collect the sensors.

While researchers have studied urban heat using mesoscale models and satellite data, that analysis does not have the spatial resolution to understand community scale variability. Urban winds also remain understudied, particularly the winds above the surface, she explained.

Winds transport pollutants, harmful contaminants, and heat, which may be relieved on some streets and trapped on others.

Michael Jensen, principal investigator for the Tracking Aerosol Convection interaction Experiment, or TRACER and meteorologist at BNL, explained that Lamer is “focused on what’s going on in the urban centers.” Having a truck that can move around and collect data makes the kind of experiment Lamer is conducting possible. Jensen described what Lamer and her colleagues are doing as “unique.”

New York model 

Katia Lamer during her experiment in Houston. Photo courtesy of U.S. Department of Energy Atmospheric Radiation Measurement user facility

Lamer had conducted similar experiments in New York to measure winds. The CMAS mobile observatory’s first experiment took place in Manhattan around the One Vanderbilt skyscraper, which is 1,400 feet high and is next to Grand Central Terminal. No balloons were launched as part of that first experiment.She launched the small radiosonde balloons for the first time this summer in Houston around the 990 foot tall Wells Fargo complex. 

Of the 32 balloons she and Mages launched, they collected data from 24. The group lost connection to some of the balloons, while interference and signal blockage disrupted the data flow from others.

Lamer plans to use the information to explore how green spaces such as parks and blue infrastructure including fountains have the potential to provide some comfort to people in the immediate area.

Such observations will provide additional insight beyond numerical models into how large an area a park can cool in the context of the configuration of a neighborhood.

This kind of urban work can have numerous applications.

Lamer suggested it could play a role in urban planning and in national security, as officials need to know the dispersement of pollutants and chemicals. Understanding wind patterns on a fine scale can help inform models that indicate areas that might be affected by an accidental release of chemicals or a deliberate attack against residents.

Bigger picture

Katia Lamer during her experiment in Houston. Photo by Steven Andrade/ BNL

Lamer is gathering data from cities to understand the scale of heterogeneity in properties such as heat and humidity, among others. If conditions are horizontally and vertically homogeneous, only a few permanent stations would be necessary to monitor the city. If conditions are much more varied, more measurement stations would be necessary.

One way to perform this assessment is to use mobile observatories that collect data. The ones Lamer has deployed use low-cost, research-grade instruments for street level and column wide observations.

Over the ensuing decades, Lamer expects that the specific conditions will likely change. Collecting and analyzing data now will enable scientists to develop a baseline awareness of typical urban conditions.

Scientific origins

A native of St.-Dominique, a small farmer’s village in Quebec Canada, Lamer was impressed by storms as she was growing up. She would often watch them outside her window, fascinated by what she was witnessing. After watching the Helen Hunt and Bill Paxton movie Twister, she wanted to invent her own version of the Dorothy instrument and start chasing storms.

When she spoke with her high school guidance counselor about her interest in tornadoes, which do not occur in Quebec, the counselor said she was the first person to express such a professional passion and had no idea how to advise her.

Lamer, who grew up speaking French, attended McGill University in Montreal, where she studied earth system science, aspects of geology and geography and a range of earth-related topics.

Instead of studying or tracking tornadoes, she has worked on cloud physics and cloud dynamics. Hearing about how clouds are the biggest wild card in climate change projections, she decided to embrace the challenge.

During her three years at BNL, Lamer, who lives with her husband and children in Stony Brook, has appreciated the chance to “push the envelope and be creative,” she said. “I really hope to stay in the field of urban meteorology.”