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Daniel Dunaief

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By Daniel Dunaief

Daniel Dunaief

What do you name after the man who’s already named everything after himself?

That is the question people will grapple with when they consider how to deploy the name of the 45th president.

Did you know, apart from edifices and casinos, the Trump name has been added to a species of small moth with yellowish-white scales on its head, called the Neopalpa donaltrumpi? Additionally, a sea urchin fossil is called Tetragramma donaldtrumpi.

What should be in the running to honor the legacy of a man who may extend his presidential legacy in 2024?

Here are a few suggestions that, hopefully, will delight and alienate people on both sides of the aisle equally.

— A pizza slicer. Called the Trump, this great divider will cut a pie into two pieces, elevating the one on the right while crushing the one on the left into a mess of tomato sauce and crumbled cheese that wants to tax the rich.

— A board game. With a rotating cast of characters, the object of the Trump Cabinet Shuffle will be for each player to hold onto as many cabinet members for as long as possible, even as many of them either want to leave or write books about their experience.

— A remote control. The former president clearly found TV a relevant and important medium. People around the country could search their couches for the “Trump,” so they can change the channel to watch Fox News, which will provide the names for the Trump Cabinet Shuffle.

— The Trump label maker. Borrowing from an episode of “Seinfeld,” people could develop a label maker named after someone who was fond of naming people and objects. The Trump label maker would default to the most common words in the Trump vernacular, including “disgrace,” “beautiful,” and “fake.”

— A fast-food franchise. Given the former president’s predilection for the fast food he served to college football players, it’s surprising no one has come up with Trump World Burgers. Each restaurant could have a game of darts, where patrons could sling darts at the faces or names of their least favorite democrats. Every wall would have a TV tuned to Fox News and every place setting would sit on top of the New York Post.

—A magic wand. Can’t you picture it? Let’s get out the Trump wand and make everything unpleasant — impeachments, investigations, and distasteful stories- disappear.

— A fertilizer company. Yeah, okay, this might seem especially harsh, but fertilizer, while it’s made from feces, is necessary for the growth of many of the foods we eat, whether we’re vegetarians and eat only greens, or carnivores and eat the meat that eats the greens.

— Oversized boxing gloves. With pictures of the former president on each hand, a boxer could put his small, medium or large hands into red Trumps to fight against the forces of evil.

— An especially tall straw pole next to a smaller pole. The taller Trump pole could show how, even at a distance, he’s leading his closest competitor. “Trump is always ahead at the polls.”

— A distorted mirror. Like the side view mirrors on cars, these Trump mirrors could accent certain features while minimizing others, creating whatever reality the viewer prefers.

— Stiff-legged pants. With material that stiffens during the playing of the National Anthem, the Trump pants would make it impossible to kneel.

— A huggable flag. Given his preference for hugging flags, someone should design a flag with arms that hug back, as in, “the Trump flag is ready for its hug.”

— A “yes” puppy. You know how people have little puppies whose heads pop up and down when you touch them on their dashboard? Someone could add a sound effect to that, like “yes, yes, yes, yes,” each time the Trump head moved.

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Photo from Deposit Photos

Amid a steady drumbeat of worry and anxiety, the last week produced several potential encouraging signs in the battle against COVID-19.

Pfizer recently applied for emergency use authorization for a vaccine for children who are five to 11 years old, a group that has returned to school but that hasn’t yet had access to any vaccines.

Pfizer will get early approval as “long as the [Food and Drug Administration] has enough data,” said Dr. Sunil Dhuper, chief medical officer at Port Jefferson’s St. Charles Hospital. “They’re going to get early approval.”

A vaccine would be a welcome defense for children who now constitute anywhere between 25% and 35% of infections, Dhuper said.

Vaccinations for those over the age of 12 have helped drive down an infection rate that had climbed toward the end of the summer.

In recent weeks, the percentage of positive cases in Suffolk County has continued to decline, with the seven-day average falling to 3.2% as of Oct. 10, according to data from the Suffolk County Department of Health.

While health officials and pharmacies continue to administer booster doses of the Pfizer BioNTech vaccine, Johnson & Johnson has applied for Emergency Use Authorization for a booster dose that enhances the immune response to the virus.

As of now, people who received J&J’s original vaccine are not eligible for the Pfizer BioNTech booster, according to Dr. Sritha Rajupet, director of Population Based Health Initiatives and director of the Post-COVID Health Clinic at Stony Brook Medicine,

Meanwhile, Merck recently produced a drug in pill form called Molnupiravir that reduced hospitalizations and death by 50% when taken within the first five to eight days of developing COVID symptoms.

The drug didn’t completely prevent hospitalizations or death but greatly reduced it, generating excitement in the health care community. Merck applied earlier this week for emergency use authorization for Molnupiravir.

“It’s a great study,” Dhuper said. “We are very delighted that there is going to be another alternative” treatment for patients.

Up to this point, hospitals, urgent care centers and doctors have not had access to an outpatient drug.

When given at the onset of symptoms, Molnupiravir acts like the flu drug Tamiflu, helping to reduce the symptoms and health challenges associated with COVID-19.

This medicine could help reduce hospitalizations, providing relief to patients and enabling hospitals to manage their resources better, Dhuper said.

Doctors remained cautiously optimistic about the ongoing battle against COVID-19. Dhuper added that the real challenge for the community would come within the next three to four weeks, during which time hospitals and count officials will watch carefully for any increase in infections in between when children return to schools and the FDA approves any vaccine for this age group.

Long haul issues

While health officials were pleased with the potential availability of additional medical tools to prevent or treat COVID-19, they said numerous residents continue to battle long haul COVID.

Described as persistent symptoms that can develop four to eight weeks after the initial symptoms, long haul COVID can include fatigue, brain fog, shortness of breath, palpitations and a wide range of other neurological discomforts.

Doctors said 10 to 35% of people who contract COVID can develop these longer-term symptoms.

Long haul COVID-19 remains a “big concern,” Dr. Gregson Pigott, commissioner of the Suffolk County Department of Health Services, wrote in an email. “We remind people who remain unvaccinated that people of all ages have suffered from long-range symptoms” from the virus. “We don’t know yet if these symptoms will be limited or if they may develop into chronic life-long conditions. We will be looking at the literature to learn more.”

Dhuper said some of those with long-haul symptoms feel as if they are “continuously living with an illness, almost like a flu.”

Such extended discomfort has an extended impact on the quality of life.

Treatment of these long-haul symptoms “is tailored to the patient’s specific symptoms,” Stony Brook’s Rajupet described in an email. “Identifying the organ systems involved and the symptoms or autoimmune conditions that have manifested are essential to developing a treatment plan.”

Rajupet suggested that leading a healthy lifestyle, with balanced sleep, nutrition and exercise can help in recovery. Stony Brook encourages this approach not only in the management of long-haul symptoms, but also for a patient’s overall health.

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Water quality impairments across Long Island during the summer of 2021. Photo from Stony Brook University

Water, water everywhere and far too many drops were not clean.

Christopher J. Gobler, endowed chair of Coastal Ecology and Conservation Stony Brook University; Peter Scully, Deputy Suffolk County Executive; Adrienne Esposito, Citizens Campaign for the Environment; Kevin McDonald, The Nature Conservancy at a recent press conference regarding water quality. Photo from Stony Brook University

That’s the conclusion of a recent summer water quality survey of Long Island conducted by Stony Brook University Professor Christopher Gobler, who is the endowed chair of Coastal Ecology and Conservation at the School of Marine and Atmospheric Sciences.

Every estuary and bay across Long Island had either toxic algal blooms and oxygen-starved dead zones this summer.

This trend threatened marine life including fish and shellfish.

Excess nitrogen from household sewage that seeps into groundwater and into bays, harbors and estuaries or, in some cases, is discharged directly into surface waters, causes toxic algal blooms.

Double the average annual rainfall, caused by storms like Hurricanes Henri and Ida, exacerbated the dumping of nitrogen from onsite wastewater into local waterways as well, Gobler explained.

Calling this the “new normal,” Gobler said the duration of the rust tide that continues across eastern Long Island is the longest since he started monitoring water quality in 2014. Additionally, the number of dead zones is near a maximum.

For the past six years before 2021, the incidence of blue-green algal blooms was higher than any of the other 64 counties in New York State, which is likely to continue in 2021.

Blue green algae produce toxins that can be harmful to people and animals and has caused dog illnesses and deaths across the United States.

“We’re the most downstate county and warmer temperatures are a driver,” Gobler explained in an email. “Excess groundwater discharge in Suffolk means more lakes and ponds here than in Nassau.”

Heavy rains, which are expected to become the new normal amid climate change that brings wetter and slower-moving storms, flush nitrogen contaminated groundwater out into the bays.

Brown and rust tides have had a severely negative impact on habitats in the area, including seagrass, and major fisheries such as scallops and clams and the coastal wetlands that protect waterfront communities from storms.

Homeowners can reduce nitrogen runoff by fertilizing their lawns less, Gobler suggested.

Onsite systems in Suffolk County are legal, but are also “quite polluting,” Gobler explained in an email.

Gobler said Suffolk County has been more aggressive than any other county in the nation in requiring advanced septic systems.

Additionally, Gobler suggests that the best way to combat these problems is to upgrade onsite septic systems.

Nassau and Suffolk completed subwatershed studies last year that identified wastewater as the largest source of nitrogen to surface waters. Excess nitrogen stimulates toxic algal blooms which can remove oxygen from bottom waters as they decay.

The New York State Department of Environmental Conservation recommends that marine waters should not have less than three milligrams of dissolved oxygen per liter to sustain fish life. Through the summer, however, more than 20 sites across the Island fell below that threshold, which, in several cases, caused fish kills.

“The research findings are conclusive,” Carl LoBue, senior scientist for The Nature Conservancy, said in a statement. “The longer we wait to fix our water quality problems, the longer it will take and the more expensive it will be.”

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Pixabay photo

By Daniel Dunaief

Daniel Dunaief

This time of year, my dog walks with relief and trepidation.

The relief comes from temperatures that have cooled off enough that his heavy fur doesn’t exacerbate the humidity and discomfort from stifling heat.

The trepidation arises out of the emergence of ominous additions to the neighborhood that change the world he knows.

The spiderwebs along fences and hanging on bushes and trees don’t bother him, but the ghosts planted in the ground, the green glow-in-the-dark skeletons and the hanging vampires terrify him, as he prefers to scamper toward the street and passing cars rather than walk near an inexplicable figure swaying in the wind, hovering over him like some supernatural predator.

And so it was, recently, that we took an early October walk through our neighborhood.

While these figures create anxiety for him, I was mulling the numerous global threats to the future for which we Americans and we humans are grappling. Global warming, debt limits, infrastructure bills, gun violence, the pandemic, partisanship, educational deficiencies, a destructive oil spill in California and everything else ricocheted around my head as I thought of the many looming crises.

A sight on the horizon snapped me out of my anxiety labyrinth. There, around the corner, appeared to be roadkill.

In the distance, I couldn’t recognize it, but I was sure that, once we got closer, my dog would pull desperately to inspect the flesh and innards of a former living creature.

Generally, when I try to pull away from decaying matter on the road, my dog seems eager to get as close as he can, like a forensic photographer or a police inspector from Law & Order, trying to figure out who might be at fault for the end of a life, whether the driver tried to maneuver away from the animal based on any skid marks nearby, or, perhaps, whether the animal contributed to its own untimely end.

I try to distract him, whistling, calling his name, tugging ever so slightly on his leash to redirect him away from these sites, hoping to keep far enough away that the flies feasting on rotting animal flesh don’t land on us.

Usually, such maneuvers have the same effect as making suggestions to my kids about what to do, like studying the bassoon because every band needs a bassoon player and many schools are lucky to have one or two such double-reeded wonders: they cause an equal and opposite reaction.

I’m sure Newton’s third law wasn’t referring to parenting, but it seems that when we say “here” they want to go “there,” and when we say “there,” they want to go “here.” My dog seems to have studied the same playbook in response to any such guidance or direction.

As we walked, I pulled left, trying to figure out what was on the road, which seemed broken into four parts. This could be a particularly unappealing mess, I thought, trying not to make a subconscious suggestion through the leash that he head straight for it.

I held my breath as a slight wind picked up from the other side of the detritus, hoping I wouldn’t smell something awful and that, somehow, neither would my dog.

As we got closer, I used my peripheral vision. That’s when I noticed something unusual. Amid the odd red and brown colors was a mixture of an orange and blue mess. What kind of animal’s innards are orange and blue? Was this a Halloween roadkill? 

I deciphered letters on the ground. That was definitely not blood. It was a Burger King wrapper, with obliterated fries, a flattened Whopper and a crushed cup.

Perhaps too focused on the Halloween decorations, the dog wasn’t at all interested or enticed by the fast food roadkill.

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A TRACER site similar to this one in Argentina is being constructed in Pearland, Texas. Photo courtesy of ARM

By Daniel Dunaief

Before they could look to the skies to figure out how aerosols affected rainclouds and storms around Houston, they had to be sure of the safety of the environment on the ground.

Researchers from several institutions, including Brookhaven National Laboratory, originally planned to begin collecting data that could one day improve weather and even climate models on April 15th of this year.

The pandemic, however, altered that plan twice, with the new start date for the one-year, intensive cloud, study called TRACER, for Tracking Aerosol Convection Interactions, beginning on Oct. 1st.

The delay meant that the “intensive observational period was moved from summer 2021 to summer 2022,” Michael Jensen, the Principal Investigator on Tracer and a meteorologist at Brookhaven National Laboratory, explained in an email.

Scientists and ARM staff pose during planning for TRACER (left to right): Iosif “Andrei” Lindenmaier, ARM’s radar systems engineering lead; James Flynn, University of Houston; Michael Jensen, TRACER’s principal investigator from Brookhaven National Laboratory; Stephen Springston, ARM’s Aerosol Observing System lead mentor (formerly Brookhaven Lab, now retired); Chongai Kuang, Brookhaven Lab; and Heath Powers, site manager for the ARM Mobile Facility that will collect measurements during TRACER. (Courtesy of ARM)

At the same time, the extension enabled a broader scientific scope, adding more measurements for the description of aerosol lifecycle and aerosol regional variability. It also allowed the researchers to include air quality data, funded by the National Aeronautics and Space Administration and urban meteorology, funded by the National Science Foundation.

The primary motivation for the project is to “understand how aerosols impact storms,” Jensen explained in a presentation designed to introduce the TRACER project to the public.

Some scientists believe aerosols, which are tiny particles that can occur naturally from trees, dust and other sources or from man-made activities like the burning of fossil fuels, can make storms stronger and larger, causing more rain.

“There’s a lot of debate in the literature” about the link between aerosols and storms, Jensen said.

Indeed, there may be a “sweet spot” in which a certain number or concentration of aerosols causes an invigoration of rainstorms, while a super abundance beyond that number reverses the trend, Jensen added.

“We don’t know the answers to those questions,” the BNL scientist said. “That’s why we need to go out there and take detailed measurements of what’s going on inside clouds, how precipitation particles are freezing or melting.”

Even though aerosols are invisible to the naked eye, they could have significant impacts on how mass and energy are distributed in clouds, as well as on broader atmospheric processes that affect weather patterns.

The TRACER study, which is a part of the Department of Energy’s Atmospheric Radiation Measurement, or ARM, user facility, could “help forecast heavy rains that can cause flash flooding,’ said Chongai Kuang, atmospheric scientist and TRACER co-investigator at BNL.

The TRACER study will explore the way sea and bay breeze circulations affect the evolution of deep convective storms as well as examining the influence of urban environments on clouds and precipitation.

Several additional funding agencies have stepped in to address basic scientific questions, including the National Aeronautics and Space Administration’s efforts to address air quality issues in Houston and the Texas Commission on Environmental Quality, which funded a study on ozone and low-level atmospheric mixing.

“Our original TRACER field campaign provided a seed for what is now a major, multi-agency field campaign with a significantly expanded scientific scope,” Jensen explained in an email.

A joint team from BNL and Stony Brook University is developing new software to scan the precipitation radar system to select and track storm clouds to observe the rapid development of these storms. Additionally, aerosol instrumentation will help provide updated information on the precursor gases and the smallest aerosol particles at the earliest stages of the aerosol cycle, Jensen explained.

Ultimately, the data that these scientists gather could improve the ability to forecast storms in a range of areas, including on Long Island.

“Understanding sea breezes and the coastal environment is a very important aspect of TRACER,” Jensen said. “Even though it’s not the preliminary focus, there’s an opportunity to learn new science, to improve weather forecasting and storm forecasting for those coastal environments.”

Researchers chose Houston because of their desire to study a more densely populated urban area and to understand the way numerous factors influence developing clouds, weather patterns and, ultimately, the climate.

“We know the urban environment is where most people live,” Jensen said. “This is taking us in new directions, with new opportunities to influence the science” in these cities.

Researchers plan to collect information about clouds, aerosols and storms everywhere from ground-based instruments stationed at four fixed sites, as well as through mobile facilities, to satellite images.

The program operates a tethered balloon which is “like a big blimp that goes up half a mile into the atmosphere,” said Heath Powers, the Atmospheric Radiation Measurement facility site manager for Tracer from Los Alamos National Laboratory.

The tethered balloon is located at Smith Point, Texas, on the eastern shore of Galveston Bay and will do low-level profiling of aerosols, winds, thermodynamics and ozone as it is influenced by bay breeze circulation, Jensen explained.

The National Science Foundation is planning to bring a C-130 plane to conduct overflights, while the group will also likely use drones, Powers added.

The TRACER study will launch around 1,500 weather balloons to gather information at different altitudes. The research will use over four dozen instruments to analyze meteorology, the amount of energy in the atmosphere and the air chemistry.

“Clouds are the big question,” Powers said. “Where they form, why they form … do they rain or not rain. We are well-positioned to get at the core of a lot of this” through the information these scientists gather.

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Dave Tuveson. Photo by Gina Motisi/CSHL

By Daniel Dunaief

While one bad apple might spoil the bunch, the same might be true of one bad cancer gene.

Cold Spring Harbor Laboratory’s Cancer Director Dave Tuveson and Derek Cheng, who earned his PhD from Stony Brook University while conducting research in Tuveson’s lab, recently explored how some mutant forms of genes in pancreatic cancer can involve other proteins that also promote cancer.

A gene well-researched in Tuveson’s lab, mutated KRAS promotes cell division. Mutant versions of this gene continue to produce copies of themselves, contributing to cancer.

Derek Cheng

Turning off or blocking this gene, however, doesn’t solve the problem, at least not in the laboratory models that track a cancer cell’s response.

In laboratory models of pancreatic cancer, a disease for which the prognosis is often challenging, other proteins play a role, creating what researchers call an “adaptive resistance” to chemotherapy.

In a paper published in the journal Proceedings of the National Academy of Sciences, Cheng, who is the first author and is currently in his final year of medical school at the Stony Brook Renaissance School of Medicine, and Tuveson showed that a protein called RSK1 interacts at the membrane with mutated KRAS. When KRAS is inhibited, the RSK1 protein, which normally keeps RAS proteins dormant, becomes more active.

“If you antagonize KRAS, you would get a rebound” as the cancer cells develop a resistance to the original drug, Tuveson said. “We found a feedback loop.”

The research “focused on identifying protein complexes with oncogenic KRAS that would potentially be relevant in pancreatic cancer,” Cheng explained in an email. “My work suggests that an RSK1/NF1 complex exists in the vicinity of oncogenic KRAS.”

While Cheng was able to show that the role of membrane-localized RSK1 provided negative regulation of wild-type RAS, it “remains to be studied what the role of the RSK1 at the membrane [is] in the context of oncogenic KRAS.”

KRAS is a molecular switch that turns on and off with the help of other proteins. With certain mutations, the switch doesn’t turn off, continuing to signal for copying and dividing, which are hallmarks of cancer cells. With specific activating mutations, the switch can lose its ability to turn off and constitutively signal for proliferation, metabolic reprogramming, and other behaviors characteristic of cancer cells, Cheng explained.

A cell with an oncogenic KRAS has the tendency to be more fit than a normal cell without one. Such cells will likely grow at a faster rate under stressful conditions, which, over time, can enable them to outcompete normal cells, Cheng continued.

When KRAS is in an oncogenic state, another protein, called RSK1 is hanging around the membrane. RSK1 has several functions and can participate in numerous cellular signaling pathways.

KRAS cytoplasm

While RSK1 is involved in protein translation by phosphorylating S6 kinase, it also has other functions at the plasma membrane, where it shuts down wild type RAS proteins.

Other researchers have suggested a negative feedback for RSK1 and NF1.

“Our contribution demonstrated some relevance of this interaction in pancreatic cancer cells,” Cheng explained in an email.

Cheng said RSK is known to have various effects, depending on the context. In the paper, the scientists showed that RSK has a “negative feedback properties, such as that, upon the removal of mutant KRAS, it has this negative regulatory role.”

Graduate student Sun Kim and post doctoral researchers Hsiu-Chi Ting and Jonathan Kastan are currently exploring whether RSK has a pro-oncogenic function on the membrane in the tumor cell.

So far, these studies suggest that while a direct inhibitor against oncogenic KRAS would likely be the greatest target for an effective therapy, cancer cells may still be able to use signals from other RAS isoforms.

“A combination of targeting KRAS and modulating regulators of RAS such as RSK1/NF1 and SOS1 may enhance therapeutic efficacy,” Cheng suggested.

Cheng is grateful for the opportunity to learn from numerous Tuveson lab members on ways cancer cells differ from healthy cells.

The discovery of the potential roles of RSK1 in cancer provides some possible explanation for the potential resistance mechanisms of mutant KRAS inhibitors.

While he was encouraged that a prestigious journal published the research, Tuveson said he hopes this type of observation “will lead to something that will be useful for a pancreatic cancer patient and not just” provide compelling ideas.

Cheng attended medical school for two years before joining Tuveon’s lab for the next six years.

Cheng defended his thesis in 2020 during the pandemic on a zoom call.

“I was one of the first people to defend with this format for both CSHL and SBU,” Cheng explained. “I was able to invite many friends and family that probably would not have been able to make the trip.”

Cheng’s family has battled cancer, which contributed to his research interests.

When he was an undergraduate, he had an uncle develop glioblastoma, while another uncle and his grandfather developed colon cancer.

“I knew I wasn’t going to be able to do much about their medical condition, but I wanted to work on something that people cared about,” Cheng explained.

Outside of the lab, Cheng enjoys working on his car and his motorcycles. He feels a sense of autonomy working on his own projects.

He’s most proud of a motorcycle for which he rebuilt the front end with parts from another model to outfit a larger brake system.

A native of St. Louis, Cheng is a fan of the hockey team, the Blues. He owns a game-worn jersey from almost every member of the 2019 cinderella team that won the Stanley cup, with some of those jerseys coming from Stanley Cup final games.

Cheng plans to apply to residency in internal medicine this year because he wants to continue applying what he learned in his scientific and medical training.

The clinical work reminds him to treat patients and not just the tumors, while scientific research trained him to loo at evidence and literature carefully to find clinical gaps, he explained.

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Pixabay photo

By Daniel Dunaief

Daniel Dunaief

If you’ve ever watched the show “The Voice,” which teenage sensation Carter Rubin from Shoreham won last year, you know the format involves celebrity judges making blind choices during a prolonged audition process.

With their backs to the performers, the judges listen to the contestants sing several bars of familiar songs, sometimes swaying, sometimes mouthing the words, until they hear something in the voices that clicks or that they think they can improve to lead these aspiring artists to the promised land of a music contract, fame and fortune.

The process is imperfect, as are most decisions we make.

The judges don’t get to rate everyone, listening to the entire array of singers before rank ordering or assembling their team. As they go, they add aspiring musicians to their teams, competing against the other judges to encourage performers to work with them.

This process is akin to so many others in so many contexts.

Many years ago, I attended a spectacular and extravagant holiday party for Bloomberg News at the Museum of Natural History. The organization had rented the entire museum during after hours. Fortunately, I brought my then-girlfriend, who is now my wife, to that event, which has given us a party to remember over two decades later.

Anyway, each room had a performer and a collection of tables with mouth-watering food. Hungry and maneuvering slowly through each room, we probably ate more than we should have in the first few rooms, until we understood the spectacular assortment of foods, culminating with sushi under the blue whale in the main room.

Pixabay photo

Having eaten more than I should prior to reaching the whale, I could only sample a few pieces of sushi before shutting down the food consumption. Well, that was true until we waited for the one person in the coatroom who was matching tickets to coats. At that point, servers brought trays of dark and white chocolate-covered strawberries up and down the line.

The point, however, is that the imperfect choices my wife and I made earlier in the evening affected how much we could eat as the night wore on.

In the last few months, I spoke with several researchers in Stony Brook University’s Department of Geosciences, including Joel Hurowitz and Scott McLennan. They are working with a rover on Mars that is choosing rocks in the Jezero crater, putting together a collection of samples that will, one day, return with a round trip mission to the Red Planet.

They can’t sample every rock that might reveal something about Mars, indicating whether life could have existed on the planet billions of years ago.

The decision to choose something in the present, like the rock in front of the rover on Mars, the current singer who is living out his or her dream on “The Voice,” or the morsel of food in a buffet that stretches throughout a museum, can limit the ones those same people have in the future.

Hopefully, along the way, we learn from the decisions we’ve made, the ones that work out and the ones that don’t, that enable us to improve our ability to make informed choices.

And, even if whatever we chose may not be exactly what we thought it was, we, like the judges on “The Voice,” might be able to mold the raw materials of our lives into something even better than we’d initially imagined.

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Dr. Sharon Nachman, chief of Division of Pediatric Infectious Diseases at the Renaissance School of Medicine at Stony Brook University. Photo from Stony Brook Medicine

Dr. Sunil Dhuper’s actions speak as loudly as his words.

The chief medical officer at Port Jefferson’s St. Charles Hospital is planning to get a booster for the COVID-19 vaccine this Thursday, after the Centers for Disease Control and Prevention authorized Friday, Sept. 24, the additional shot for a range of adults, including those in jobs that put them at an increased risk of exposure and transmission, such as frontline health care workers.

Earlier, the U.S. Food & Drug Administration announced Sept. 22 that “a single booster dose” was allowed “for certain populations” under the emergency use authorization, although the EUA “applies only to the Pfizer-BioNTech COVID-19 vaccine.” 

Dhuper received his first vaccination in January and would like to raise his immunity.

“I am very eager to get the booster dose,” he said in an interview. “I reviewed scientific data from all over the world — from the United States, Israel, the United Kingdom — and I had reflected that, after six months after the second dose, it’s time to get a third dose.”

While St. Charles and other hospitals haven’t required a booster, Dhuper believes that state and national guidance will likely recommend it before too long.

“Over time, I do anticipate people may begin to get severe infections or get hospitalized” if they haven’t enhanced their immunity with a booster, he said. “It would be prudent to get the booster dose in the arms of those who are fully vaccinated.”

Stony Brook University Hospital is providing boosters to employees and to eligible members of the public.

Meanwhile, Northwell Health and Huntington Hospital are deliberating how to proceed and will announce a decision soon, according to Dr. Adrian Popp, chair of infection control at Huntington Hospital.

While boosters are available for education staff, agriculture and food workers, manufacturing workers, corrections workers, U.S. Postal Service employees, grocery store workers, public transit employees and a host of others, the overall infection rate in Suffolk County has stabilized over the past few weeks.

Decline in infections

As of Sept. 25, the seven-day average rate of positive tests in the county fell below 4% for the first time since Aug. 15, dropping to 3.9%, according to data from the New York State Department of Health.

“We think the numbers might have plateaued,” Dhuper said. That decline coincides with the increasing number of people who are vaccinated. In Suffolk as at Sept. 29, 1,043,478 people (70.7%) have received at least one dose and 950,058 (64.3%) are fully vaccinated, according to Covid Act Now. Anybody who is at least 12 years old is eligible to be vaccinated.

The number of COVID Patients from Huntington Hospital has fallen in the last month, dropping to 20 from about 30, according to Popp. Five patients are in the intensive care unit at the hospital with COVID.

Dr. Sharon Nachman, chief of pediatric infectious diseases at Stony Brook Children’s Hospital, described the downward trend in the seven-day average as “great news,” but added that such an infection rate is “not close to where we need to be to say we have turned a corner.”

The current infected population includes children, as “more kids are getting infected,” she said, with children currently representing 25.7 percent of all new COVID cases nationwide.

With the FDA and CDC considering approving the emergency use authorization that provides one-third of the dosage of the adult shot for children ages 5 to 11, Nachman urged residents to vaccinate their children whenever the shot is available to them.

“There is no advantage to picking the right age or dose for a child,” she explained in an email. “If they are 12 now, get that dose. If they are 11 and 8 months [and the CDC approves the vaccine for younger children], don’t wait until they are 12 to get a different dose. Get the dose now that is available for that age.”

When younger children are eligible for the lower amount of the vaccine, Dhuper also urged them to get that lower dose, which he feels “offers a good level of protection for the foreseeable future.”

Nachman said she sees the issue of weight or age bands regularly in pediatrics.

“The take-home message is to not play any games and treat the child at the age or weight that they are now and not wait for them to be older or heavier,” she suggested.

As for the next month, Dhuper cautioned that the county may show another peak, particularly with the increase of indoor activities where the spread of the more transmissible Delta variant is more likely. At this point, concerns about the Mu variant, which originated in South America and was much more prevalent in the United States and in Suffolk County in June, has decreased.

“We were seeing 5% of the cases in New York state were Mu variants and the remaining were Delta,” Dhuper said.

Popp estimated that the Mu variant constitutes between 0.1% and 0.3% of cases.

The World Health Organization has urged wealthier nations like the United States not to administer boosters to their populations widely before the rest of the world has an opportunity to vaccinate their residents.

Dhuper said the United States has contributed 500 million doses to the rest of the world this year and plans to donate about 1.1 billion doses to the rest of the world in 2022.

“I hope that other upper and middle income nations can do the same, so we can get [the shots] in the arms of those who need them,” he said.

Popp urged people to recognize that COVID is a global disease.

“We in the U.S. will not be safe until the epidemic is cleared in other parts of the world as well,” he explained in an email. “I believe it is in our national interest to help other countries fight the COVID epidemic.”

 

Popp said the United States has plenty of vaccine, with enough for boosters and to vaccinate those who haven’t gotten a shot.

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Semir Beyaz (center) with research assistant Onur Eskiocak, left, and graduate student Ilgin Ergin. Photo by Gina Motisi/CSHL

By Daniel Dunaief

High fat diets present numerous health problems for humans and mice, which are often used as a model organism to understand disease.

In a recent multi-disciplinary study with mice, Cold Spring Harbor Laboratory Fellow Semir Beyaz and 32 colleagues from 15 other institutions explored how a high fat diet affects the development of intestinal tumors.

Semir Beyaz. Photo by Gina Motisi/CSHL

The diverse team of scientists brought together a range of expertise to discover the way a high fat diet disrupts the cross talk among the microbiome, stem cells and immune cells, triggering tumors through the reduction in the expression of an important gene, called major histocompatibility complex II, or MSC-II.

“This work nicely integrates efforts in stem cell biology, immunology, microbiology and metabolism in the context of understanding how diet is linked to cancer,” Beyaz explained in an email. With such interdisciplinary studies, “we hope to improve our understanding” of the mechanisms that link nutrition to diseases.

The paper, published in Cell Stem Cell, for which Beyaz is the first and corresponding author, shows how a high fat diet leads to immune evasion of tumor initiation stem cells due to the suppression of the immune recognition molecule MHC-II.

At the center of this study, the MHC-II gene encodes a protein that presents antigens, or foreign substances, to the immune system. When a cell is infected or cancerous, immune cells detect the unwelcome agents through their surveillance of MHC molecules, Beyaz said.

A high fat diet also results in the alteration of immune cells in the micro environment and the signals that they produce, called cytokines.

“The novel finding of our study is that the crosstalk between stem cells, microbes and immune cells is critical for eliminating tumor initiating cells and this cross talk is dampened in response to a high fat diet, demonstrating a mechanistic basis for how high fat diets may promote cancer,” said Beyaz.

A current hypothesis, which has some supporting evidence in Beyaz’s study, suggests that diet-related factors might facilitate early onset colorectal cancer.

To be sure, researchers need to conduct more work to understand the environmental factors that facilitate early onset colorectal cancer, Beyaz explained. “The knowledge of what causes early onset colorectal cancer in young adults is very limited,” he added.

Semir Beyaz with visiting clinical researcher Aaron Nizam (left) and research tech Katherine Papciak. Photo by Gina Motisi/CSHL

Beyaz believes diet is one of the most important environmental factors that contribute to cancer risk. Diet could affect sleep, stress and other factors.

“There are so many things we don’t know about how diet affects our body,” he said. “That’s why I’m very excited to work on understanding these mechanisms.”

Beyaz said the mice in his study consumed a lard-based pro-obesity diet that was high in carbohydrates.

A diet that is lower in carbohydrates and higher in fat is more similar to a ketogenic diet, which could have other outcomes. His ongoing studies are trying to tease apart some of these differences.

To counteract the effect of diet on the development of cancer, Beyaz plans to activate the altered pathways by using either microbes or small molecule drugs.

“We believe if we promote immune surveillance by activating these pathways, we can elicit preventative and therapeutic strategies against cancer,” he explained.

Additionally, in his ongoing research, Beyaz plans to address numerous other questions that link diet to disease.

An increasing number of studies are exploring how diet and microbes affect cancer, which he described as a “hot topic.”

Beyaz believes a high fat diet might turn on or off some genetic sequences, enabling the latent development of cancer.

His unique niche involves searching for a connection between diet and perturbations that affect cross talk among cells. While this field has numerous challenges, Beyaz suggested he was “drawn” to that difficulty.

Beyaz’s expertise is in stem cell biology and immunology. He appreciates and enjoys the opportunity to interact with researchers from other disciplines that could lead to actionable progress.

Hannah Meyer. Photo from CSHL

While science has to be reductionistic and focused on one molecule or cells at times, new conceptual and technical advances have made it possible for the lines between disciplines in biology to disappear slowly, he explained.

Beyaz and his colleagues are looking forward to taking some of the next steps in this effort.

For starters, he is excited to expand this study, to understand whether there is a threshold for a high fat diet that favors the growth of tumors. Diets that fall below a potential threshold might not promote the growth or development of tumors.

Such a threshold could become clinically relevant, providing health care workers with a pre-cancerous marker that could signal the need for lifestyle changes and medical vigilance that could stave off or avoid the formation of disease-bearing and life-threatening tumors.

“We have some ongoing work to delineate such thresholds and proxies,” Beyaz said. Additionally, they would like to see whether this effect is reversible, to determine whether an altered microbiome might promote the expression of MHC-II, which could derail the tumor forming process.

Pawan Kumar. Photo from SBU

Beyaz’s collaborators on this work include Hannah Meyer, who is a fellow at Cold Spring Harbor Laboratory Fellow, and Pawan Kumar, who is an Assistant Professor in the Department of Microbiology and Immunology at the Renaissance School of Medicine at Stony Brook University.

In his life outside the lab, Beyaz, who enjoys fishing, gardening, and hiking, avoids excessive sugar and fat consumption. He doesn’t eat fast food or consume sugary drinks.

Originally from the town of Samandag which is near the Mediterranean Sea in the southeastern part of Turkey, Beyaz enjoys cooking and is fond of making lamb, beef, chicken and eggplant kebabs.

When he was growing up, Beyaz said science was a passion for him.

“It is not a job or a career,” he explained. “It is the way I find meaning in life, by learning how to ask and (sometimes) answer questions at the edge of cumulative human knowledge.”

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Pixabay photo

By Daniel Dunaief

Daniel Dunaief

In a fractured and uncertain world, the skill sets that make us marketable to potential friends, employers and neighbors have shifted.

Sure, competence, professionalism and experience can and do come in handy in the context of numerous environments. These days, though, getting along with others and navigating through the cacophony of frustration beamed into our living rooms and phones on an hourly basis seems to have elevated what otherwise might seem like trivial skill sets in another time.

I have come up with a list of skills or, perhaps more appropriately, qualities that might be helpful in the modern world.

I don’t overuse the word “literally.” To emphasize a point, people often literally throw the word “literally” into phrases, as in “I literally hate tofu.” I’m not sure you can figuratively hate tofu, but I don’t overuse that word.

I keep a straight face: even when confronted with outrageous claims in which others hold fast to ideas, to heroes or to patterns I find questionable or even objectionable, I don’t wince, roll my eyes or shout them down until I’m in the safe space of my home with my wife.

I know how to write a handwritten note. Electronic communication has become so ubiquitous that sharing a personal touch that comes from writing something by hand has scarcity value.

I have trained my dog to do exactly what he wants. Sure, other people have trained their dogs to sit, roll over, fetch the newspaper and come to them when they call, but my dog does exactly what he wants. That means when he wags at me, he’s genuinely excited to see me and he’s not just wagging because he’s expecting some immediate reward or punishment.

I can find almost anything in a supermarket. Having spent an embarrassing amount of time searching the supermarket for foods that satisfy four diets and that take the place of in-person dining and social interactions, I can find most items sooner than supermarket employees.  

Through a hard-target search of every bed sheet, blanket and pillowcase, I can find the remote control. While that may seem trivial, it shows a willingness to go the extra mile to avoid having to take a few extra steps to change the channel.

I speak teenager. Yes, they are wonderful people who not only have a shorthand way of speaking, but also have a tendency to multitask while they are talking, looking at their phones or speaking through a mouthful of food. I can interpret much of what they say even when they appear to be offering disconnected sounds in a guttural and frustrated language.

I can finish an entire chapter in a non James Patterson book without checking email or texts. That means I can concentrate for longer periods of time. Patterson is excluded because the chapters in his violent novels are often shorter than this column.

I can make myself laugh. Every week, I enter the New Yorker cartoon contest. The captions I write never win, but they make me laugh.

I have a wealth of untapped ideas. I look at all the masks around me and think, “Hmm, I could come up with so many new mask products.” For example, how about mood masks, which change color depending on the person’s mood? Or, perhaps, masks with the outline of states, presidents of the United States, or images of abolitionists, important women in history or slogans? Masks could become the equivalent of educational posters hung on the walls of classrooms or, if you prefer, facial bumper stickers, giving someone starting at our covered mouths a chance to read or see something new.

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