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Daniel Dunaief

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National Geographic Explorer-in-Residence Lee Berger and leader of the excavation expedition, inside the Rising Star cave in South Africa where fossil elements belonging to H. naledi, a new species of human relative, were discovered. The find was announced by the University of the Witwatersrand, the National Geographic Society and the South African National Research Foundation and published in the journal eLife. Photo by Robert Clark/National Geographic
Where: Rising Star, formed within Dolomitic Limestone Lee Berger, the leader of the excavation expedition, inside the Rising Star cave, watches a monitor in the command center. Photo by Robert Clark/National Geographic
Discovered on July 28th, 2022. This picture shows an image of Panel B in the Hill Antechamber exhibiting numerous engravings and etchings on the ancient dolomitic wall. The panel shows repeated etchings likely done over a considerable period. The etchings include geometric figures such as squares, ladders, triangles, crosses, and X’s. Image from Berger et al. (2023b).
Discovered on July 28th, 2022. This picture shows an image of Panel B in the Hill Antechamber exhibiting numerous engravings and etchings on the ancient dolomitic wall. The panel shows repeated etchings likely done over a considerable period. The etchings include geometric figures such as squares, ladders, triangles, crosses, and X’s. Image from Berger et al. (2023b).
A closeup of the non-geometric image from the Hill Antechamber burial chamber that is found at the top of Panel B as described in Berger et al (2023b). Note the upside-down cross shaped etching to the left of the carving as well as other etchings to the right and below. The material discoloring the surface has not as yet been analyzed but appears to be secondarily applied to the surface in order to highlight the image in low light. Image from Berger et al., 2023.
An image of the Panel A crosshatch engraving in the passage between the Hill Antechamber burial chamber and the Dinaledi Burial Chamber from Berger et al (2023a). The image is taken using a polarizing filter to highlight the various non-natural etchings on the surface. The roughly horizontal wavy lines at the bottom of the image which are crossed by the engravings is a fossil algal stromatolite found in the native dolomitic rock. Earlier etchings can be seen behind the crosshatch, possibly having been obscured by covering the surface with cave dirt as described in the scientific papers. Image from Berger et al., 2023.
A close up of the base of the Panel A crosshatch engraving in the passage between the Hill Antechamber burial chamber and the Dinaledi Burial Chamber described in Berger et al (2023a). The roughly horizontal wavy lines at the bottom of the image which are crossed by the engravings is a fossil algal stromatolite found in the native dolomitic rock and clearly illustrate the non-natural origin of the more prominent etchings as they cross the fossil. Image from Berger et al., 2023.
Breaking news from the Richard Leakey Memorial Conference

By Daniel Dunaief

A species of archaic humans is defying conventional wisdom about what it means to be human.

Lee Berger, National Geographic Explorer in Residence and paleoanthropologist.

Homo naledi, which were discovered in a cave about 25 miles away from Johannesburg, South Africa, had brains that were about a third the size of ours. That, previous research suggested, likely limited their ability to engage in a range of activities, like burying their dead or creating symbols.

Wrong and wrong.

In an expedition through narrow caves that required him to lose 55 pounds just to get to the site, Lee Berger, National Geographic Explorer in Residence and Lead of the Rising Star program, along with a team of other scientists, studied the remains of these humans that lived over 236,000 years ago. The bones they studied and, in some cases excavated, were buried deep in the Rising Star Cave.

Along the wall of a cave, the researchers also found symbols, including crossed lines and swirls.

“Big brains don’t explain what we thought they explain,” Agustín Fuentes, Professor of Anthropology at Princeton University and National Geographic Explorer and On-Site Biocultural Specialist, said during a press briefing announcing the discoveries. This research “takes humans off the pedestal.”

The research, which was shared at the Richard Leakey Memorial Conference at Stony Brook University on June 5, is published in the journal eLife.

Berger wanted to share his latest findings with the conference, particularly given the important role Leakey played in his career.

Berger had known Leakey for 34 years. When they met, Leakey, who was his “idol,” directed Berger to follow his dream of searching for fossils in South Africa. Leakey and Berger remained close throughout the decades.

“I owe him my entry into this field,” said Berger.

Indeed, Berger feels that Leakey was, “in some ways, responsible for the discovery” about the burials and cave drawings of Homo naledi. “I’m very personally indebted” to Leakey.

Extraordinary effort

While scientists don’t know what the lines in the dolomitic limestone walls signified, they believe Homo naledi, whose name in Sotho language means “star,” made those marks. 

Natural processes over the course of over 200,000 years wouldn’t have left such a distinctive pattern. In addition, the depth of the markings, which would have taken considerable effort and a tool to create, indicate a concerted and sustained physical effort.

The dolomite is about half as hard as a diamond, which would have taken an “extreme amount” of work, Berger said. Several of the lines suggest multiple efforts to make carvings. “These are engravings that are not done in one sitting,” he said.

During the press briefing, Berger indicated that other species of early humans didn’t leave any evidence of entering the same cave. “There’s no evidence of humans” other than the scientists who published the paper “that entered the cave,” he said.

At this point, researchers, who are trying to minimize any disturbance in the cave, haven’t pinpointed an exact date for the symbols.

“In time, we’ll likely be able to date” the symbols, said Berger. The researchers arrived at the approximate date and linked the symbols to Homo naledi through association and context, he explained.

Homo naledi are the only humans who left any evidence of their presence in the cave.

Moments after discovery, Lee Berger holds a photographic scale next to a hashtag, or crosshatched engraving in the passage between the Hill Antechamber burial chamber and the Dinaledi Burial Chamber known as Panel A. Photo by Mathabela Tsikoane, Courtesy Lee Berger and the National Geographic Society.

Researchers described the arduous process of descending through narrow passageways to arrive at the burial site, which Berger discovered in 2013.

The site is extraordinarily difficult for modern humans to navigate. In addition to losing weight to get through small openings, Berger tore his rotator cuff climbing out of the site last July. He is still recovering, but said losing weight and even sustaining an injury was worth the effort.

While modern scientists use headlamps and battery-powered lights to record their discoveries, earlier humans would have had to carry some form of portable fire with them to bring their dead to their burial sites and to make carvings in the walls.

“How they’re making that fire and the exact mechanism of transport, I think, will be established over the next several years as we study all the occurrences of it,” Berger said.

“For us to say something clearly, definitely, strongly, again as [Berger] has said, we need to go back and excavate some more and check out more areas that we might have missed because clearly we walked straight past this,” said Keneiloe Molopyane, National Geographic Explorer and Lead Excavator of Dragon’s Back Expedition.

New perspectives

As far as a DNA analysis, the team hasn’t yet found anything they can test in the fossils. They are planning to test the sediment.

The researchers have left large amounts of evidence in place, which includes multiple other burials that haven’t been excavated. Berger suggested that the images and information from this site “provide as robust evidence for burial and graves as for practically any grave ever published for humans or otherwise.” Researchers examining this information will realize that “more works needs to be done.” As for what that entails, one of the plans is to bring additional technology and specialists into the area.

Homo naledi “intensely altered this space across kilometers of underground cave systems, and I think that deserves not just the involvement of our team, but the involvement of every scientist around the world who can participate, and perhaps technologists and other people who have ideas about how/ what we do,” Berger added.

As for the implications of this research, the scientists suggested that the discovery and the analysis will continue to alter the perspectives of researchers and students of human history.

“All of us who write textbooks or major articles about this probably have to go back and shift what we said about big brains, meaning, complex meaning-making behavior, or the kind of complex experiences of grief, social community, that’s associated with mortuary and funerary practices,” Fuentes said. “It makes us think about human evolution really in a new way, and puts us back closer to a starting point, and showing again that we know a lot less than we thought we did.”

 

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Chengfeng Yang Photo by Zhishan Wang

By Daniel Dunaief

This is part two of a two-part series.

As Erin Brockovich (the real life version and the one played by Julia Roberts in the eponymous movie) discovered, some metals, such as hexavalent chromium can cause cancer in humans.

Chengfeng Yang and Zishan Wang

Environmental exposure to a range of chemicals, such as hexavalent chromium, benzo(a)pyrene, arsenic, and others, individually and in combination, can lead to health problems, including cancer.

In March, Stony Brook University hired Chengfeng Yang and Zhishan Wang, a husband and wife team to join the Cancer Center and the Pathology Departments from Case Western Reserve University.

The duo, who have their own labs and share equipment, resources and sometimes researchers, are seeking to understand the epigenetic effect exposure to chemicals has on the body. Yang focuses primarily on hexavalent chromium, while Wang works on the mechanism of mixed exposures.

Last week, the TBR News Media highlighted the work of Wang. This week, we feature the work of Yang.

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When he was young, Chengfeng Yang was using a knife to make a toy for his younger brother. He slipped, cutting his finger so dramatically that he almost lost it. Doctors saved his finger, impressing him with their heroic talent and inspiring him to follow in their footsteps.

Indeed, Yang, who earned an MD and a PhD from Tongji Medical University, is focused not only on answering questions related to cancer, which claimed the life of his mother and other relatives, but also in searching for ways to develop new treatments.

A Professor in the Department of Pathology at the Renaissance School of Medicine at Stony Brook University and a member of the Stony Brook Cancer Center, Yang has his sights set on combatting cancer.

“Our research always has a significant clinical element,” said Yang. “This is related to our medical background.”

He is interested in studying the mechanism of cancer initiation and progression and would like to develop new strategies for treatment.

Yang and his wife Zhishan Wang recently joined the university from Case Western after a career that included research posts at the University of Pennsylvania, Michigan State University, and the University of Kentucky.

The tandem, who share lab resources and whose research staffs collaborate but also work independently, are focused specifically on the ways exposures to carcinogens in the environment cause epigenetic changes that lead to cancer.

Specifically, Yang is studying how hexavalent chromium, a metal commonly found in the environment in welding, electroplating and even on the double yellow lines in the middle of roads, triggers cancer. It is also commonly used as a pigment to stain animal leather products.

Yang is focused mainly on how long cancer develops after exposure to hexavalent chromium.

People can become exposed to hexavalent chromium, which is also known as chromium 6, through contaminated drinking water, cigarette smoking, car emissions, living near superfund sites and through occupational exposure.

Yang has made important findings in the epigenetic effect of metal exposure. His studies showed that chronic low-level chromium six exposure changed long non-coding RNA expression levels, which contributed to carcinogenesis. Moreover, his studies also showed that chronic low level exposure increased methylation, in which a CH3 group is added to RNA, which also contributed significantly to chromium 6 carcinogenesis.

“It is now clear that metal carcinogens not only modify DNA, but also modify RNA,” Yang explained. Metal carcinogen modification of RNAs is an “exciting and new mechanism” for understanding metal carcinogenesis.

By studying modifications in RNA, researchers may be able to find a biomarker for the disease before cancer develops.

Yang is trying to find some specific epigenetic changes that might occur in response to different pollutants.

Stony Brook attraction

Yang was impressed with the dedication of Stony Brook Pathology Chair Ken Shroyer, whom he described as a “really great physician scientist. His passion in research and leadership in supporting research” helped distinguish Stony Brook, Yang said.

Yang is confident that Stony Brook has the resources he and Wang need to be successful, including core facilities and collaborative opportunities. “This is a very great opportunity for us, with strong support at the university level,” he said.“We plan to be here and stay forever.”

Yang is in the process of setting up his lab, which includes purchasing new equipment and actively recruiting scientists to join his effort.

“We need to reestablish our team,” he said. “Right now, we are trying to finish our current research project.”

He hopes to get new funding for the university in the next two to three years as well. After he establishes his lab at Stony Brook, Yang also plans to seek out collaborative opportunities at Cold Spring Harbor Laboratory, which is “very strong in RNA biology,” he added.

A return home

Returning to the Empire State brings Yang full circle, back to where his research experience in the United States started. About 23 years ago, his first professional position in the United States was at New York University.

Outside of work, Yang likes to hike and jog. He is looking forward to going to some of Long Island’s many beaches.

He and Wang live in an apartment in South Setauket and are hoping to buy a house in the area. The couple discusses science regularly, including during their jogs.

Working in the same area provides a “huge opportunity” for personal and professional growth, he said.

Yang suggested that his wife usually spends more time training new personnel and solving lab members’ technical issues. He spends more time in the lab with general administrative management and support. Wang has “much stronger molecular biology skills than I have,” Yang explained in an email, whereas he has a solid background in toxicology.

Growing up, Yang said he had an aptitude in math and had dreamed of becoming a software engineer. When he applied to college, he received admission to medical school, which changed his original career path.

Once he started running his own experiments as a researcher, he felt he wanted to improve human health.“Once humans develop disease, in many cases, it’s very expensive to treat and [help] people recover,” he said. “Prevention could be a more cost effective way to improve health.”

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Pictured above, from left to right: Simons Foundation President David Spergel, Jim and Marilyn Simon, Stony Brook University President Maurie McInnis and Governor Kathy Hochul. Photo by John Griffin/Stony Brook University

Stony Brook University’s former Math Department chair is making history.

Jim Simons, with his wife Marilyn and through the Simons Foundation, is giving the largest ever unrestricted gift of $500 million to the university’s endowment.

The donation, which the Simons Foundation will provide in installments over the next seven years, will more than double the endowment for the SUNY flagship school.

As a part of a program Governor Kathy Hochul (D) created last year, New York State will provide a one-to-two endowment match while the school, with support from the Simons Foundation, reaches out to other donors for additional support.

SBU expects the gift to total about $1 billion.

“Today is indeed a historic day for Stony Brook University,” President Maurie McInnis said during a press conference at the Simons Foundation headquarters in Manhattan on June 1. “I cannot overestimate the tremendous impact” the gift will have.

The university anticipates using the gift, named the Simons Infinity Investment, for student scholarships for a diverse student body, endowed professorships, research initiatives, development of new academic fields and clinical care.

McInnis, who is the sixth president of SBU, suggested this kind of support helped create and shape some of the nation’s most prestigious universities, including Harvard and Yale.

Looking at how they started, “you’ll find that they were bolstered by generous supporters who were ambitious and wise enough to see the potential of the institutions and invest in the future,” McInnis said at the press conference. “Because of those supporters, look where they are now. That is the trajectory we are on,” thanks to the support from Jim and Marilyn Simons and the foundation president, David Spergel.

McInnis believes the funds will help make the university a place where every student meets their potential, thanks to the support and the “deep sense of belonging in every corner of campus.”

The funds would also help ensure that researchers have access to the “best labs and equipment” so they can “chase the next discovery” and where learners will come to the university because they “know they have the resources they need to make a difference.”

History of giving

The Simons family has a long history of giving back to the university, which was so important in their lives.

Starting with a much more humble gift of $750 in 1983, the Simons family, with this gift and other recent commitments, have pledged $1.2 billion to a university that Gov. Hochul declared a flagship of the state university system in 2022.

“I’m so happy to be here today, to be able to give back to Stony Brook, which has given so much to me,” Marilyn Simons said at the press conference.

When she started as a student at Stony Brook, Marilyn said her father was a subcontractor who, along with her brother and cousin, did some of the brickwork at university buildings.

In addition to earning her bachelor’s at Stony Brook, Marilyn Simons also earned her Ph.D.

“I’m grateful to Stony Brook for all it’s given me,” she said. “I hope many others will invest along with us.”

Jim Simons became chairman of the Math Department when he was 30. He hired 10 faculty in his first year and the same number in his second.

When Hochul stood up to speak, Simons interrupted her.

“I’ve known” all six presidents of Stony Brook, the former Math Department chair said. McInnis “is the best.”

Hochul appreciated the direction and vision of SBU’s leadership, recognizing the sizeable financial commitment the state would now have to meet.

When she came up with the endowment idea, “I didn’t realize it was going to be so expensive for me,” Hochul laughed. If that inspired the Simons Foundation to come forward, “it was worth it.”

A public institution like Stony Brook “has no limits right now,” Hochul added. “I guarantee across the world, they’ve all heard of Stony Brook right now.”

A winning streak

The $500 million gift from the Simons Foundation continues a winning streak, making 2023 a memorable and landmark year for the university.

A few weeks ago, Stony Brook, with a $100 million commitment from the Simons Foundation, won the state’s contest to turn Governors Island into a center for climate science called the New York Climate Exchange. [See story, “SBU will develop $700M climate center on Governors Island,” April 26, TBR News Media website.]

The center, which will cost $700 million to construct and is expected to open in 2028, will house research laboratories, host community discussions and train 6,000 people per year to work in green energy jobs.

SBU has “shown that it has the knowledge, the authority and the boldness to bring together the most eminent institutions to address the world’s leading challenges,” McInnis said.

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Photo from SBU

By Daniel Dunaief

From June 5 to 9, Stony Brook University will host a conference titled “Africa: The Human Cradle: An International Conference Paying Tribute to Richard E. Leakey” at the Charles B. Wang Center, 100 Nicolls Road, Stony Brook.

The University, which has 15 speakers among the 40 scientists delivering lectures, will celebrate the achievements of famed and late scientist and conservationist Richard Leakey and will bring together researchers from all over the world to celebrate the research in Africa that has revealed important information about early human history.

Stony Brook will host the conference in connection with the Turkana Basin Institute, which Leakey founded and is located in his native Kenya. The National Geographic Society, which provided financial support for Leakey’s seminal research for decades, is serving as a partner for the gathering.

Scientists from seven countries will discuss the latest developments in fossil research, archaeological and paleoecological records, as well as advances in geology, geochronology and genomic research.

Leakey inspired scores of scientists and made important discoveries that helped highlight Kenya’s central role in the narrative of human evolution. He died in early January 2022 at the age of 77.

Lawrence Martin, Professor in the Department of Anthropology at Stony Brook and Director of the Turkana Basin Institute, organized the meeting, along with Professor Frederick Grine. Stony Brook President Maurie McInnis and Jill Tiefenthaler, CEO of the National Geographic Society will provide opening remarks.

Martin, who called Leakey a “close friend” and a “mentor,” said the idea for the conference started in the days after Leakey’s death. The Stony Brook president “wanted Stony Brook to be the place that celebrates Richard Leakey as a scientist” and to recognize his “impact on the world.”

Organizers for the conference, which involved nine months of planning, wanted to focus on the “human story in Africa as it’s emerged” since Leakey’s ground breaking research, Martin explained. He expects the conference will involve an emotional outpouring, reflecting the personal and scientific impact Leakey had on so many other researchers and anticipates the meeting will be “state of the art” and will “pull things together in a way that’s never been done before.”

Leakey, who made his first major hominin discovery in 1964 at Lake Natron in Tanzania, worked with Stony Brook University for 20 years. SBU will share a National Geographic video tribute to Leakey on June 5 that will include pictures of his parents Louis and Mary Leakey, who made important fossil discoveries and were involved in numerous important scientific projects, through the last few years of Leakey’s life. 

Scientific talks

Martin suggested that the multi-disciplinary nature of the power-packed line up reflected Richard Leakey’s scientific views and bigger picture understanding of discoveries across a range of fields.

Leakey didn’t see geology, biology, paleobiology and other fields as separate, Martin explained. He saw all those disciplines as different sources of how humans adapted and evolved, which reflects the “integrated view” the conference is “looking to encourage.”

Richard Leakey examines fossils at the Turkana Basin Institute

Bernard Wood, Professor in the Department of Anthropology at George Washington University, joined Leakey on his first expedition to Lake Turkana. Wood will deliver the first talk, on June 5 at 2:15 p.m. He will focus on how Leakey inspired many scientists from a range of disciplines, with his intellectual curiosity leading to numerous research projects.

Lee Berger, explorer and scientist with the National Geographic Society, will deliver a talk on June 5 at 3:50 pm that will discuss recent discoveries of human origins. Martin said Berger’s talk would be “global news” and will likely be “covered all over the world.”

The first day will conclude with a free public lecture at 5 p.m. in the Staller Center’s Recital Hall by Richard Leakey’s daughter Louise, who will provide an overview of the discoveries and expeditions of the Koobi Fora Research Project in the Turkana Basin.

While Louise Leakey’s talk is free, attendees need to pre-register. The cost to attend the entire conference is $100.

Carrie Mongle, Assistant Professor in the Department of Anthropology at Stony Brook University, will be giving a talk on June 7 at 1:15 pm. She plans to attend all of the talks, as she sees this as an “incredible opportunity to see some of the world’s top paleoanthropologists come together and present the latest research in the field.”

In her lecture, Mongle will present new data related to the reconstruction of the hominin family tree.

“One of Richard’s scientific legacies is the extraordinary number of hominin fossils he was able to add to our collective understanding of human evolution,” she said. “Phylogenetic inference is a critical step in figuring out how all of these fossils come together to form the human family tree.”

On June 6 at 2:15 p.m., SBU Assistant Professor Marine Frouin will give a talk about the contribution of luminescence dating to the chronology of Pleistocene deposits in Turkana. Frouin uses luminescence dating techniques to study human evolution.

Turkana Basin Institute: Richard Leakey
All photos downloaded with permission from:
www.flickr.com
Username: turkanabasin
Password: knmwt15000

On June 7 at 9 a.m., Stony Brook Associate Professor Sonia Harmand, who worked closely in her career with Leakey and whose family developed a close relationship with the late researcher and conservationist, will describe research in the early Stone Age. Harmand and Directrice de Recherche Emerite at Centre National de la Recherche Scientifique (CNRS) Hélène Roche will discuss evidence in light of biological and environmental changes in East Africa and will present future research directions.

Also on June 7at 2:40 p.m., Jason E. Lewis, lecturer at Stony Brook, will discuss the implications of a new Early Pliocene hominin mandible from Ileret, Kenya on the origins of Australopithecus.

Stony Brook Associate Professor Krishna Veeramah, will conclude the talks on June 7 at 4:10 p.m. with a discussion of how the analysis of modern and ancient DNA has helped understand African prehistory.

Martin, who will wrap up the talks on June 9 at 12:20 p.m., said he thinks Leakey would appreciate what people say and how much impact he had on the field.

“He was quite a self-effacing person,” Martin said. “He wouldn’t have liked too much fuss about him.” He would, however, have appreciated that people recognized that he made “significant contributions in the area of the human evolutionary story,” among so many others fields.

For a full schedule of events and lectures, visit www.stonybrook.edu/richard-leakey/

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Pixabay photo

By Daniel Dunaief

Daniel Dunaief

Shhh. Listen. If what you hear is nothing, then maybe you’re onto something.

Noise envelops us. Some of it, like the sound of a Broadway musical, the waterfall laughter of a giggling child, or the deep resonant breath of a humpback whale surfacing amid floating cubes of ice in Alaska can give us peace, pleasure and joy.

Many noises, however, are irritants or worse. We step out of a loud airplane onto a jetway, where loudspeakers announce the boarding in group four of a flight awaiting takeoff. We walk through a crowded airport, as fathers shout to their children, a woman calls to ask Breanne if she “wants fries with her burger,” and a man informs his wife that he “has to pee so badly that he’s not sure he’s going to make it.”

We step outside of the airport, where whistles from people directing traffic echo in our ears and where officials in orange vests bark orders at drivers to “vacate this spot immediately!”

We try to ignore many of the harsher and more abrasive sounds, even though our nervous system tracks noises as a way to protect us in case someone yells something we need to hear.

And then there are those wonderful moments when we hear nothing, not even the buzzing of a lightbulb, a dog drinking in the next room, or a cat cleaning himself on a nearby chair.

Silence.

If it lasts long enough, it’s the pause that refreshes, giving our ears a rest and our brains a chance to hear an inner voice that might otherwise get lost.

We can find those moments when we’re on our own. When we’re surrounded by others, the silence is harder to discover, as we either speak or hear the noises they make as they unwrap a newspaper, chew their gum, or shake their leg up and down so rapidly that the material from their pants makes a repetitive rubbing sound.

But then, we can go to a meditation or yoga class or a religious or memorial service and reflect with others who sit still like a slope of shaded stones in an Ansel Adams photo.

During those moments, we can slow our breathing, think beyond the constant fast twitch need to act and react to our phones, and can allow our minds to make unexpected connections.

During one of those recent times, I pondered symmetry in nature, where you can draw a line down the middle of something like our faces, and see that the image on one side, excluding freckles, beauty marks, and that scar from the time we tripped and got stitches, is incredibly similar to the one on the other.

With so much chaos in nature, I wouldn’t expect such symmetry. At a distance, most leaves have remarkable symmetry, as do the shape of most animals. Human designs often have a pleasing symmetry, with windows, flying buttresses and A-frame houses looking remarkably similar on the left and right. Almost every field or arena for a sporting event has some symmetry, except for those with irregular outfield fences.

During a recent service, I enjoyed time when I couldn’t look at my phone and when I could read religious text. I haven’t considered these texts in a while and was drawn in by their drama and story value, as opposed to the spiritual and life guidance I often imagine. Basic struggles for power, sibling rivalries, and the search for food and stability dominate these narratives, which makes it clear why religion (and mythology) continue to offer connections for people whose lives, at least on the surface, are considerably different from the ones people lived lo those many years ago.

Ultimately, silence can be refreshing, giving us auditory time and space to reflect and to clean a cognitive filter cluttered with chaos and cacophony.

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Zhishan Wang. Photo from Chengfeng Yang

By Daniel Dunaief

This is part one of a two-part series.

As Erin Brockovich (the real life version and the one played by Julia Roberts in the eponymous movie) discovered, some metals, such as hexavalent chromium can cause cancer in humans.

Chengfeng Yang and Zhishan Wang

Environmental exposure to a range of chemicals, such as hexavalent chromium, benzo(a)pyrene, arsenic, and others, individually and in combination, can lead to health problems, including cancer.

Recently, Stony Brook University hired Chengfeng Yang and Zhishan Wang, a husband and wife team to join the Cancer Center and the Pathology Departments from Case Western Reserve University in Ohio.

The duo, who have their own labs and share equipment, resources and sometimes researchers, are seeking to understand the epigenetic effect exposure to chemicals has on the body. Yang focuses primarily on hexavalent chromium, while Wang works on the mechanism of mixed exposures. 

In part one, TBR News Media highlights the work of Wang. Next week, we will feature the efforts of Yang.

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In certain areas and specific job sites, people can be exposed to environmental pollutants.

Sometimes, the introduction of a metal or element can cause cancer after long term exposure. The effect of another carcinogen can be synergistic in triggering disease, triggering a stronger progression of cancer than an individual exposure alone.

Zhishan Wang, who joined Stony Brook in March and is a Professor of Research in the Department of Pathology, is trying to understand what changes this mixed exposure creates at a molecular level.

“If we find out some gene or pathway change, we can try to intervene,” said Wang, who is a member of the Stony Brook Cancer Center and earned MD and PhD degrees from her native China.

Among the many possible environmental triggers, Wang chose to study arsenic, which is common in rock soil and water and is present in some places in drinking water.

“People living in high exposure areas to arsenic and [who] are also cigarette smokers have a significantly higher risk of lung cancer,” she said.

Arsenic can cause three different kinds of cancer: skin, bladder and lung cancer. For skin cancer, Wang explained that direct contact can lead to the kind of irritation that promotes the disease. 

As the heavy metal works its way through the body, parts of it get excreted through the urine system, which means that bladder cells come into contact with it as well.

For a long time, scientists knew arsenic exposure through drinking water caused lung cancer. The underlying mechanism for the development of that cancer was not well understood. 

Wang’s lab studies the mechanism by which arsenic and benzo(a)pyrene (or BAP) co-exposure increases lung cancer risk. Exposure to arsenic alone causes cancer, but it takes a long time in animal models. Arsenic and BPA co-exposure significantly increases lung cancer risk.

Wang’s study showed that co-exposure increases lung tumor burden and malignancy. She plans to continue to study the mechanism of how arsenic and BAP co exposure increases lung cancer risk.

“That’s our big goal: to try to find some useful method to prevent this tumor from happening,” she said.

Wang believes the cancer cells caused by the mixed exposure increases the number of cancer stem cell-like cells, which could mediate therapeutic resistance.

Wang explained that generating the mouse model took considerable time and effort. She tried to find the exposures during particular windows of time that lead to cancer.

“By using this model, we can do a lot of data analysis” including single cell analysis and can determine which cluster or pathway will change.

Choosing SBU

Wang suggested she and her husband chose Stony Brook for several reasons. The couple would like to help the University earn a National Cancer Institute (NCI) designation, which would give scientists the ability to compete for ambitious, well-funded, multidisciplinary efforts.

Both Wang and Yang “lead NCI-funded research programs that will enhance the [Cancer Center’s] eligibility for NCI designation,” explained Kenneth Shroyer, chair of the Pathology Department at Stony Brook.

Shroyer, who described both researchers as “highly competitive candidates with the potential to enhance the status of any cancer center,” is looking forward to working with his newest recruits.

Wang is eager to use the tissue bank at Stony Brook, which Shroyer explained has also attracted other cancer research scientists recruited to the Renaissance School of Medicine at Stony Brook.

The new scientists also hope to tap into the expertise at nearby Cold Spring Harbor Laboratory, which has become one of the leading centers in creating organoids. 

In the early years of her training during her MD and PhD years in China, Wang developed her technical skills. Through her career, she has worked on several genes that play important roles in carcinogenesis. Down regulation of the gene known as SOCS3, for suppressor of cytokine signaling 3, plays an important role in arsenic and BAP co-exposure caused lung tumorigenesis.

Early in their careers, Wang worked in her husband’s lab for seven years until she received her own research funding.

Outside of work, Wang enjoys playing badminton and ping pong. She also cooks every day. She and her husband bring her home cooked meals to work.

When she was in high school, Wang had ambitions to become a writer. Her teachers regularly read her work out loud to the class.

Her father, who was a lawyer, had encouraged her to join the legal profession. She had heard that people called others “smart” when they joined the fields of Science, Technology, Engineering and Mathematics. “I want people to call me smart,” she said, so she changed her career and went to medical school at Tongji Medical University where she earned top scores. 

Her father had a stroke, surviving afterwards for seven years. When she was in medical school, Wang hoped to learn ways to help him. Wishing she could have done more, she pursued clinical research in the lab. She passed the tests to become a practicing physician in the United States, but she was more inspired to work as a scientist.

As for her work at Stony Brook University, Wang appreciates the beauty of Long Island. She hopes this is their “last move,” as they continue their careers.

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Pixabay photo

By Daniel Dunaief

Daniel Dunaief

While for now, the pandemic is officially in the rearview mirror, according to the World Health Organization, it’s worth considering what we can and can’t blame on COVID-19. For starters, here are a few things that aren’t the fault of the pandemic.

— A favorite sports team’s defeat. Every team had to deal with COVID-19. The pandemic didn’t affect my team’s best athletes any more than any other team’s stars.

— The weather. It’s going to rain, and it’s going to be too hot and too cold. That happened before the pandemic, and it’s going to happen afterward. Global warming, if anything, might have slowed slightly as more people stayed home each day.

— Unrequited love. Authors throughout history have found this topic particularly appealing. A would-be romantic goes out into the world with a proverbial heart filled with affection and admiration. Cupid hits that person with an arrow, creating a wellspring of dedication and devotion toward someone who doesn’t return the favor. The pandemic might have made it harder to know where we stood with each other, but unrequited love will continue to cause problems and lead to sad-but-relatable romantic comedies.

— Bad grades. We all have moments when we don’t study enough, the right way, or even the right material. The pandemic might have made it harder to focus or to care about theorems or memorizing dates, but it’s not the fault of the virus. It might have been tougher to concentrate in those early days, with dogs barking, parents yelling into Zoom calls, and people dropping off food at our front door.

— Anger in Washington. This is one of the easiest to dispel. Did you pay any attention to the vitriol coming out of the nation’s capital before 2019? It’s not as if the parties suddenly decided fighting each other was more valuable than getting anything done or compromising. The words under the Washington DC license plate shouldn’t read “taxation without representation,” which refers to the fact that residents pay taxes but don’t have federal representation. Instead, it should read: “Grrrrrrrrrrr!”

— Biased journalism. As a member of the media, I understand the frustration with the written and spoken words on TV and in print. The left hates Trump; the right hates Biden and ne’er the ‘twain shall meet. The pandemic didn’t pour gasoline on that dumpster fire. Media organizations staked out their territory prior to the pandemic and have remained more faithful to their talking points than many people do to their own marriage vows.

Okay, now, what about the things we can blame on the pandemic.

— Mental health strain. While the pandemic may be gone, we haven’t wrapped our arms around the mental health impact. We spent way too much time on our phones, making us feel simultaneously connected and disconnected while the pool of frustration continues to get deeper.

— Educational gaps. Students will never get back those days and the lessons they missed during the pandemic. Classes condensed their syllabi, lowering requirements and expectations for each class and for graduation. Students of all ages missed lessons and assignments that might have inspired them and that would have helped them reach previous educational requirements.

— Social graces. A first-grade teacher recently told me that their school still can’t bring all the first-grade classes together. When they do, the students argue about resources and space. Prior to the pandemic, students from several classes could easily play together. Hopefully, that will change as the students age and fill in gaps in their ability to interact.

Even as we hope to move past the pandemic, we can’t ignore the difficult reality, forcing parents, teachers, children and members of society to relearn lessons about acting and interacting. No, we can’t take cues from Washington, but maybe we can overcome deficiencies exacerbated by the pandemic.

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John Moses. Photo courtesy of CSHL

By Daniel Dunaief

It sounds like something straight out of a superhero origin story.

With resistance to widely used drugs becoming increasingly prevalent among bacteria, researchers and doctors are searching for alternatives to stem the tide.

That’s where shape shifting molecules may help. Cold Spring Harbor Laboratory Professor of Organic and Click Chemistry John Moses and his team have attached the drug vancomycin to a molecule called bullvalene, whose atoms readily change position and configuration through a process called a thermal sigmatropic rearrangement as atoms of carbon break and reform with other carbon atoms.

The combination of the bullvalene and vancomycin proved more effective than vancomycin alone in wax moth larva infected with vancomycin resistant Enteroccoccus bacteria.

“Can I make a molecule that changes shape and will it affect bacteria? That was the question,” Moses said. The promising early answer was, yes!

Moses believes that when the bullvalene core is connected to other groups like vancomycin, the relative positions of the drug units change, which likely change properties related to binding.

The urgency for novel approaches such as this is high, as drug resistant bacteria and fungi infect about 2.8 million people in the United States per year, killing about 35,000 of them. 

In his own life, Moses said his father almost died from a bacterial infection five years ago. Vancomycin saved his father’s life, although the infection became resistant to the treatment. Other drugs, however, conquered the resistant strain.

“We need to work hard and develop new antibiotics, because, without them, there will be a lot more misery and suffering,” Moses explained.

To be sure, an approach like this that shows promise at this early stage with an insect may not make the long journey from a great idea to a new treatment, as problems such as dosage, off target effects, toxicity, and numerous other challenges might prevent such a treatment from becoming an effective remedy.

Still, Moses believes this approach, which involves the use of click chemistry to build molecules the way a child puts together LEGO blocks, can offer promising alternatives that researchers can develop and test out on a short time scale.

“We shouldn’t be restricted with one set of ideas,” Moses said. “We should keep testing hypotheses, whether they are crazy or whatever. We’ve got to find alternative pathways. We’re complementary” to the standard approach pharmaceutical companies and researchers take in drug discovery.

Looking to history, Moses explained that the founders of the Royal Society in 1660 followed the motto “nullius in verba,” or take nobody’s word for it. He believes that’s still good advice in the 21st century.

The shape shifting star

Moses has described this bullvalene as a Rubik’s Cube, with the parts moving around and confounding the bacteria and making the drug more effective.

The CSHL scientist and his team don’t know exactly why shape shifting makes the drug work in this moth model.

He speculated that the combination of two vancomycin units on either side of a bullvalene center is punching holes in the cell wall of the bacteria.

Moses is eager to try to build on these encouraging early developments. “If you can make it, then you can test it,” he said. “The sooner the better, in my opinion.”

Moses acknowledged that researchers down the road could evaluate how toxic this treatment might be for humans. It didn’t appear toxic for the wax moth larvae.

Welcoming back a familiar face

Adam Moorhouse
Photo by Rebecca Koelln

In other developments in his lab, Moses recently welcomed Adam Moorhouse back to his team. Moorhouse, who serves as Chemistry Data Analyst, conducted his PhD research in Moses’s lab at the University of Oxford.

Moorhouse graduated in 2008 and went on to work in numerous fields, including as an editor for the pharmaceuticals business and for his own sales consultancy. In 2020, he had a motorcycle accident (which he said was his fault) in which he broke 16 bones and was hospitalized for a while. During his recovery, he couldn’t walk.

At the time, he was working in the intense world of sales. After the accident, Moorhouse decided to build off his volunteer work with disabled children and become a high school teacher. After about 18 months of teaching, Moorhouse reconnected with Moses.

“It’s nice getting here and thinking about chemistry and thinking about ideas and communicating those ideas,” Moorhouse said.

He has hit the ground running, contributing to grants and helping to translate intellectual property into commercial ventures.

The chance to work on projects that get molecules into humans in the clinic was “really exciting,” Moorhouse said. “I’m back to try and support that.”

Moorhouse will be working to procure funding and to build out the business side of Moses’s research efforts.

“Where I’d like to lend a hand is in driving ongoing business discussions,” Moorhouse said. He wants to “get these small molecules into the clinic so we can see if they can actually treat disease in humans.” The vehicle for that effort eventually could involve creating a commercial enterprise.

Like Moses, Moorhouse is inspired and encouraged by the opportunity for small operations like the lab to complement big pharmaceutical companies in the search for treatments.

Moses believes the work his lab has conducted has reached the stage where it’s fundable. “We’ve done something that says, ‘we checked the box,’” he said. “Let’s find out more.”

Currently living on campus at CSHL, Moorhouse appreciates the opportunity to do some bird watching on Long Island, where some of his favorites include woodpeckers, herons, egrets, robins and mockingbirds.

He is tempted to get back on a motorcycle and to return to mountain biking.

As for his work, Moorhouse is excited to be a part of Moses’s lab.

“Back in my PhD days, [Moses] was always an idea machine,” Moorhouse said. “The aim is to move ideas to the clinic.”

 

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By Daniel Dunaief

Daniel Dunaief

Most of us engage in group movements that don’t make our day. We get in a car, sit in traffic as we wait for other cars to pass or for lights to turn green, all the while surrounded by other people doing the same thing.

Group movements start at a young age, which we witness when we stop for school buses that pick up students. A line of buses then brings those students into the parking lot.

Our entertainment and discretionary decisions follow some of the same patterns as we travel by car, bus, or train to sporting events or, in our case, recently, concerts.

And yet, the experience and the excitement we share in our interactions are markedly different.

My wife and I attended a recent performance by Janet Jackson as a part of her Together Again tour.

Unlike 15 years ago when we last saw Janet Jackson at Madison Square Garden, we asked our son to take us to and from the concert. That’s one advantage of the passage of time.

We left the car about four-tenths of a mile from the arena. Walking more rapidly than the cars inching along next to us, we followed the line of people trekking along the shoulder to the entrance.

A woman leaned out of her window and asked us if we knew if the place would sell refreshments. We said we hoped so, but weren’t sure. She gave us an appreciative and friendly wave, despite the fact that we were completely unhelpful.

People wore a wide range of outfits, with some clad in T-shirts showing a younger version of Janet from earlier concerts and others adorned in dresses and high-heeled shoes.

While waiting to get inside the arena, we spoke with a couple behind us, who were celebrating their 5th wedding anniversary and her graduation from nursing school.

Once Ludacris took the stage, the crowd, which included every age group from young children to gray-haired seniors, shouted, swayed and responded to his songs.

Cooled by a light and intermittent breeze, the crowd roared its appreciation with the left side screaming at full throat to outdo the right.

A father, mother and daughter two rows ahead of us had clearly come to see Janet, sitting and eating popcorn despite Ludacris’ exhortations for everyone to stand and shout.

Before Janet took the stage, the arena displayed a photo montage from 50 years of Janet, showing the many faces of her public life.

I wasn’t tall enough to see over a man two rows in front of me. I looked around him to see the stage and the numerous screens with images of Janet and her dancers.

As I listened and watched a show in which Janet changed her wardrobe several times, I appreciated the energy such a concert must take to put on at the age of 56. She isn’t sprinting around the stage, but she still breaks into some of her iconic moves, with sweat gleaming on her forehead.

She urged the audience to turn on their phone flashlights, which created a wave of swaying bright lights along the lawn and in the seats.

While I reveled in familiar songs, I wished the heavy and loud bass and drums didn’t overwhelm Janet’s voice. I also second-hand smoked a high dose of marijuana, as the smokestack attached to the person two seats away from me must have felt as lit up as the stage by the finale.

The experience, which I shared with thousands of thrilled audience members, brought me back to the times and places where I heard these same songs decades ago. As we followed the crowd back to our cars (or, in our case, to meet our son), I could feel the glow the concert created for an appreciative audience. For a few hours, the strangers we might otherwise see as obstacles on the way to something else came together during a joyful concert.

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Joel Gonzalez, right, with his wife Amanda, daughter Isabella and son Julian. Photo courtesy Gonzalez

Joel Gonzalez was waking up in the middle of the night, gasping for air. During the day, if he ate too quickly, he felt like food was getting stuck in his throat.

In 2018, Gonzalez, who lives in Coram and is a high school counselor, was diagnosed with gastroesophageal reflux disease, or GERD. A small hiatal hernia, in which part of his stomach bulged through an opening in his diaphragm and into his chest, caused the condition.

Gonzalez started taking medications, which helped relieve the symptoms and enabled him to sleep without experiencing discomfort or waking up suddenly.

In August 2022, after learning that his hiatal hernia had gotten slightly larger and deciding he didn’t want to continue taking reflux medicine for the rest of his life, he met with Dr. Arif Ahmad, director of the St. Charles and St. Catherine of Siena Acid Reflux and Hiatal Hernia Centers of Excellence, to discuss the possibility of surgery.

Gonzalez was so convinced that the surgery would help and confident in Dr. Ahmad’s experience that he scheduled the procedure during that first meeting. Since his November surgery, which took about an hour, he hasn’t had any GERD symptoms and is not taking any medication for the condition.

Gonzalez said he would “absolutely” recommend the surgical procedure, which became a “simple decision” after consulting with Dr. Ahmad.

Caused by a mechanical problem with a valve at the bottom of the esophagus called the lower esophageal sphincter that allows stomach acid to enter the esophagus, GERD affects over 20% of the population.

Symptoms of GERD vary, which means doctors can and do take a range of approaches to treatment.

Hospitals, including St. Charles, St. Catherine of Siena, Stony Brook and Huntington Hospital, have been ramping up their efforts to evaluate and treat GERD.

Port Jefferson-based St. Charles and Smithtown-based St. Catherine of Siena, both part of the Catholic Health system, have been expanding these services at the Acid Reflux and Hiatal Hernia Centers of Excellence.

“There is a big need” for this increasingly focused effort to help patients dealing with the symptoms of GERD, said Dr. Ahmad.

At St. Charles and St. Catherine, Dr. Ahmad, who has been doing hiatal hernia and GERD-correcting surgery for over 25 years, created the center to ensure that the nurses on the floor, the people who do the testing, and the recovery staff are aware of the specific needs of these patients.

Dr. Ahmad has done presentations for the staff to ensure they have “the highest level of expertise,” he added.

Dr. Ahmad, also the director of the Center of Excellence in Metabolic and Bariatric Surgery at Mather Hospital, said he could perform surgery, if a patient needs it, at any of the hospitals, depending on a patient’s request.

Stony Brook’s efforts

At the same time, Stony Brook recently created a multidisciplinary Esophageal Center at Stony Brook Medicine, designed to provide a collaborative care model for diagnosing and treating GERD.

The center provides minimally invasive endoscopic treatments as well as surgical options.

Dr. Lionel D’Souza, chief of endoscopy, said the center provides a cohesiveness that “allows an evaluation by a group of people who are experts and can communicate with each other” to provide a patient-specific plan.

Dr. D’Souza suggested people seek medical attention from their primary care physician or gastroenterologist if they experience any of the following conditions: heartburn every day or severe heartburn several times a week, trouble swallowing, food getting stuck in the throat, anemia, blood in the stool or weight loss without another explanation.

Other partners in the Stony Brook GERD Center include Dr. Olga Aroniadis, chief of the division of gastroenterology, Dr. Alexandra Guillaume, director of the gastrointestinal motility center, and Dr. Konstantinos Spaniolas, chief of the division of bariatric, foregut and advanced GI surgery at Stony Brook Medicine and director of Stony Brook’s bariatric and metabolic weight loss center.

“When someone has a lot of excess weight, the chance of developing GERD is a lot higher,” Dr. Spaniolas said. “Sometimes, getting patients through a program to facilitate with weight loss can help [people] avoid GI symptoms, such as heartburn.”

Stony Brook will see patients in different parts of its network and then, depending on the needs, will determine who is best-suited to start their work up and treatment, Dr. Spaniolas added.

While a potential option, surgery is among a host of choices for people who have ongoing heartburn.

Huntington Hospital, meanwhile, will begin offering esophageal motility testing starting in June. Patients can call Northwell Health’s Heartburn and Reflux Center to schedule an appointment.

A team of gastroenterologists, surgeons and dietitians will work with patients at Huntington to determine the cause of GERD and possible treatments, according to Dr. David Purow, chief of gastroenterology.

Soft foods

Those who have surgery return to solid foods gradually.

Marlene Cross, a resident of St. James who struggled with GERD for about a decade, had the procedure in March.

For the first few weeks, she ate primarily liquids, with some protein drinks and puddings. She added Farina and oatmeal to her diet and then could eat flaky fish.

At 83, Cross, who lost sleep because of GERD-induced heartburn, said the surgery was a success.

“I’m not running a marathon, but I’m definitely feeling a lot better,” said Cross, who is a retired teacher’s assistant for special education students.

Cross urged others who might benefit from surgery to “see a specialist and ask questions and do it” if the doctor recommends it. “The younger you do it, the better.”

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