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Daniel Dunaief

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Photo from METRO

By Daniel Dunaief

Daniel Dunaief

Even months after we emerged from our Covid caves, I still appreciate the wonder and joy of getting out again, of seeing people, of making plans, and of going on a date with my wife.

Recently, we went to see “Hadestown.”

We didn’t know much about it, except that it had won several awards. As soon as we sat down, we fell on the playbill, reading about the origins of the story, checking out the cast, and immersing ourselves in the experience.

I will admit, sheepishly, that we also used our TV app to watch a few minutes of the Jeopardy! Tournament of Champions. Our son thinks our addiction to that show is laughable and he didn’t even see the movie “Rainman,” in which Dustin Hoffman’s character is addicted to the show “The People’s Court.”

Anyway, after Jeopardy! ended, we took in the room. We studied the arrangement of the set, where it was clear the musicians would be on stage. When I was in high school, I thoroughly enjoyed playing in the pit orchestras of “West Side Story” and “The Wizard of Oz.” One of the wonders of the experience was the opportunity to dress casually, as we played in a true, recessed pit where we were heard and not seen.

As we got closer to the start of “Hadestown,” the auditorium filled with people sporting a wide range of attire, from casual to festive.

In the first few moments of the show, we were transported, as a colorful Hermes pranced around the stage, interacting with the other actors and reaching out to the audience.

The appreciative guests lapped up his over-the-top gestures and movements, as he introduced us to some of the characters and the band, who filled the stage with vitality, music and movement.

During intermission, I watched two women in the row in front of me. One was talking, while the other nodded absent-mindedly while playing solitaire. Perhaps that’s a carry over from too much time at home. Then again, who am I to complain? We watched a TV show in the moments before “Hadestown” started, so we’re also accustomed to our isolated entertainment.

To my left, two women with bright blonde hair opened a ziplock bag filled with small sugar cookies. After they each ate one, the woman holding the bag dropped a cookie on the floor. I felt it hit my shoe before it settled on the ground.

Now, I am a bit OCD with germs. Okay, fine, that’s like being a bit pregnant. I’m OCD and have been known to wash my hands so often in the winter that my skin becomes incredibly dry, cracks and bleeds.

So, what would I have done with that cookie? I would have picked it up, put it in my coat pocket, forgotten about it for about two weeks and, upon rediscovering it, would have thrown it in the garbage and, of course, washed my hands immediately afterwards.

What did she do? The woman picked it up, briefly scraped off the parts she imagined must have touched the floor and my shoe, blew on it and broke it in half. She gave her companion one half, she kept the other, and they both, gulp, ate it.

I laughed nervously and made a mental note, not that I ever need one, to wash my hands just because, well, yuck!

In the second half of “Hadestown,” the show followed a similar pattern, as one sad, longing song gave way to another.

At the critical moment of the story, the woman who had been playing solitaire in front of us objected to the tragic turn of events.“Oh no, don’t do it!” she shouted.

While I wasn’t surprised by the ending to a story filled with mournful songs and that Hermes told us was sad, I chuckled as she tried to change the script from the balcony.

Yes, it was great to be out and to appreciate the show, the music, and the other guests.

All the world, as Shakespeare suggested, is a stage, including for the appreciative members of the audience.

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Ke Jian Liu

By Daniel Dunaief

Ke Jian “Jim” Liu, who arrived at Stony Brook University in late July, plans to help build effective, interdisciplinary research teams.

Ke Jian Liu

Most recently at the University of New Mexico, Liu joins Stony Brook as a Professor in the Renaissance School of Medicine’s Department of Pathology and Associate Director of Basic Science at the Stony Brook Cancer Center.

“In my mind, Stony Brook, research wise, is outstanding,” Liu said in an interview. “The quality of the faculty is excellent.”

Liu will rely on the team building experience he honed while serving as Distinguished Professor in the Department of Pharmaceutical Sciences and Associate Dean for Research in the College of Pharmacy at the University of New Mexico. He also worked for eight years at Dartmouth Medical School, where he focused on developing larger collaborations.

“I really enjoy working with people and building teams,” Liu said.

In a note announcing Liu’s arrival, Kenneth Shroyer, chair in the Department of Pathology, recognized Liu’s multidisciplinary approaches in his research. Shroyer explained that Liu has used techniques ranging from chemical to biochemical to biophysical, and from the molecular and cellular level to animal models, to answer specific biological questions.

Shroyer wrote that Liu would focus on opportunities for grant development within several programs. 

At the Cancer Center, Liu said he plans to continue the effort to help Stony Brook earn National Cancer Institute designation.

To achieve that designation, Stony Brook will need to continue to provide outstanding medical care, demonstrate community engagement and highlight what makes Stony Brook different from everyone else, he said.

“It takes a village to do that,” Liu said.

He praised the efforts of current Cancer Center Director Yusuf Hannun, who recently announced his plans to step down as head of the center, triggering a nationwide search for a replacement.

Liu said an ideal candidate for that position would have clinical experience.

Player coach

With a busy research effort and lofty leadership goals, Liu explained that he’s able to tackle numerous challenges at once.

“I consider myself a player coach,” he said. “I enjoy research. I have my own research grant and am working with my students and post docs.”

Liu typically maintains a lab with five to six people at different levels. His research has two branches, cancer and stroke, that most people likely consider unrelated, but for which he has found connections.

“People always think, ‘Cancer is cancer and stroke is stroke and they are two entirely different diseases,” Liu  said. As a basic researcher, however, he looks at the cells and the molecules involved in both conditions.

“At a molecular level, a molecule doesn’t care where it is,” he said. “When a disease develops, the biological fundamental process is the same. For me, it’s interesting to look at [whether] certain processes that occur in the brain also occur in cancer.”

Liu’s cancer research focuses specifically on the molecular processes that become carcinogenic when metals like arsenic enter people’s bodies. A well-described poison in numerous murder mysteries, arsenic can contaminate drinking water, get incorporated into crops like rice, or can appear in fruit juices.

When metal enters the body, it doesn’t just cause damage everywhere. It has to find a certain molecular target with which to interact.

What Liu and researchers in his lab have discovered is that the target for arsenic is often the same pathways the body uses in zinc. A transition metal, zinc provides an important element as a part of transcription factors that are critical in biological processes.

Arsenic, however, replaces zinc, which is “one of the major mechanisms for carcinogenesis,” Liu said.

Fortunately for residents of Long Island, arsenic isn’t as prevalent as it is in the midwest and the southwest.

“Long Island doesn’t have too much arsenic in drinking water,” Liu said, although people are still exposed to it through fruit juices, rice and other products.

Arsenic also causes vascular disease issues and anemia. People who develop these other conditions in response to arsenic are also at higher risk to develop cancer. The specific types of cancers arsenic causes are lung, skin and bladder cancer.

“Arsenic is the dirty bomb” in the body as it creates multiple problems, Liu said. “Arsenic interacts with those key zinc molecules.” 

Overlap between stroke and cancer

In highlighting the overlaps between the two fields of research, Liu related how the brain has one of the highest concentrations of zinc in the body.

When people have strokes, their brain cells have oxidative stress, which causes a flood of zinc into the brain tissue that also damages cells.

“We are trying to understand how zinc is released and how zinc causes damage to the brain,” Liu said.

Stroke and cancer also have molecular overlaps regarding oxygen. In a stroke, a blood clot causes a blockage of blood flow. Without oxygen, a situation called hypoxia, neurons start to die.

By contrast, a tumor grows in a hypoxic environment, using energy from sugars like glucose, rather than relying on oxygen for its growth.

Liu emphasized the importance of continuing to provide oxygen to brain regions around a clot even before trying to remove the clot or restore blood flow.

A goal for his 100th year

Originally from Beijing, China, Liu and his wife Jiao Ding enjoy traveling. Their daughter Sarah Liu is a resident at Vermont Medical Center and their son Evan Liu is a PhD student at Stanford.

An avid tennis player who plays the sport at least twice a week, Liu is looking forward to attending his first U.S. Open next year.

He and his former tennis partner in New Mexico joked that their goal is to be in the top 20 in the United States when they are 100 years old.

Liu chose the American name “Jim” because it sounds similar to the second syllable of his given name, Ke Jian.

“If people can’t pronounce your name, they shy away,” he said. He believes it’s important to “make yourself adaptable.”

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Eye test. METRO Photo

By Daniel Dunaief

Daniel Dunaief

Have you ever sat in the eye doctor’s chair and had them shift from one lens to another, asking you if A or B is better or if 1 or 2 is clearer?

I did that many times growing up, particularly because my father was an ophthalmologist.

Oftentimes, even now, I’m not exactly sure whether the first image or second is better. In fact, I asked my father to let me see them again. I could hear him groan as I said, “One, no, no, two, no, wait, one.”

The same subtle differences sometimes define who we are and how we see ourselves.

Sometimes, the question of our identity is simple, at least to us. Are we American and do we live in the Middle Atlantic States?

Other questions also might elicit reflective responses. Are we religious and, if so, do we celebrate Christmas, Hannukah, or Kwanza? Or, maybe we’re not religious at all, and we think of life and ourselves outside the structure of an organized religion.

We also might define ourselves by our race or our combination of races. I had a close friend in college who was so many races that she said she could check off every box on each survey to reflect her mixed heritage. 

But, then, when we define ourselves as part of a group, whether it’s a race, religion, political affiliation or other, what does it mean to meet someone or interact with someone from a different group? If we’re a Republican and someone else is a Democrat, should we behave as if we are the Montagues and the Capulets?

Does the fact that they are different mean we don’t have to be respectful of them or that we need to protect our own first before considering their needs?

Surely, such insular, tribal and protective thinking should violate our sense of right and wrong. Can we prejudge people or suggest that we care less about them because they weren’t born with some of the same elements that define us?

Several of the ways we identify ourselves don’t typically involve choices. I can’t choose to be much taller, even if I might want to be, and I can’t choose to be Taiwanese, even if I have many close friends who trace their roots to Taiwan.

We have choices in our identity that affect our behavior and define us.

We might, for example, choose not to be a bystander, but, rather a defender. People don’t, or shouldn’t, wake up in the morning and hope to witness someone bully someone else and feel gratified that they observed cruelty.

Perhaps, we might consider ourselves protectors or active community members. Remembering this part of our identity, we might be more inclined to help.

We might also choose to identify ourselves as grateful. We might choose a host of adjectives to describe ourselves — smart, flexible, sympathetic, understanding. Ultimately, through our thoughts, words and actions, we can demonstrate whether those descriptions apply or whether our self-identification is a mismatch with our behaviors.

Conflicts arise in us when one part of our identity is at odds with another. We might, for example, want to help others, even though we might realize doing so comes with risk to ourselves.

Standing up for someone at the lower end of the social pecking order might cause a bully to turn his attention to us. We might run the risk of injury or worse by trying to help others in dangerous situations.

At those moments, we can be grateful to those among us who protect us against all kinds of threats, who join the armed forces, or the police or firefighters.

On this, the day before Veterans Day and two weeks before Thanksgiving, we can be thankful for all those people who contribute to our lives and to our country.

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Arkarup Banerjee. Photo ciourtesy of CSHL

By Daniel Dunaief

Brain cells don’t always have easily discovered roles, the way various instruments do in an orchestra.

Sometimes, different cells share a function, making it possible to perform various tasks or to process information from the environment, while other times, different cells play their own part in making it possible for an organism to optimize its circuitry to act and react on the world.

So it is for the tufted and mitral cells of land based vertebrates, which are part of the olfactory system, sending signals to the brain about the odors and triggering thoughts about moving towards a desired food or away from the scent of a predator. In many studies, the names have been used interchangeably, as scientists were not sure how to separate them.

Florin Albeanu. Photo courtesy of CSHL

Researchers have spent considerable time studying mitral cells, which project into a region of the brain called the piriform cortex. These cells are nicely organized into one layer, which makes them easy to identify and are bigger in size compared to tufted cells.

Mitral cells, which have been the celebrated stars of the olfactory system, are easier to see and sort out than their nasal cousins, the tufted cells which, by contrast, are slightly smaller.

Recently, two scientists at Cold Spring Harbor Laboratory, Florin Albeanu, an Associate Professor, and Arkarup  Banerjee, an Assistant Professor, published a study that suggested there’s more than meets the eye, or, maybe, the nose, with these tufted cells.

Tufted cells, it turns out, are better at recognizing smells than mitral cells and are critical for one of two parallel neural circuit loops that help the brain process different odor features, according to a study the scientists published in the journal Neuron at the end of September.

“People had assumed mitral cells were very good at” differentiating odor, but “tufted cells are better,” Albeanu said. “How they interact with each other and what the mitral cells are computing in behaving animals remains to be seen.”

Albeanu and Arkarup, who had performed his PhD research in Albeanu’s lab before returning to CSHL in 2020, exposed mice to different odors, from fresh mint to bananas and at different concentrations. They chose these compounds because there are no known toxic effects. The scientists also screened for compounds that elicited strong responses on the dorsal surface of the olfactory bulb that they could access using optical imaging tools.

It is hard to distinguish mitral and tufted cells when doing recordings. Optical imaging, however, enabled them to see through layers and shapes, if they were recording activity in a particular type of cell.

So, Albeanu asked rhetorically, “why is this exciting?”

As it turns out, these two types of cells project to different regions of the brain. Mitral cells travel to the piriform cortex, while tufted cells travel to the anterior olfactory nucleus.

It appears at this point that tufted cells are more likely to share information with other tufted cells, while mitral cells communicate with other mitral cells, as if the olfactory system had two parallel networks. There may yet be cross interactions, Albeanu said.

Mitral cells may be part of a loop that helps enhance and predict smells that are important for an animal to learn. Tufted cells, however, appear superior to mitral cells in representing changes in odor identity and intensity. By flagging the tufted cells as sources of olfactory information, the researchers were able to suggest a different combination of cells through which animals detect smells.

“A large fraction of people in the field would expect that mitral cells and the piriform complex are representing odor identity more so than the tufted cells and the anterior olfactory nucleus, so this is the surprise,” Albeanu explained in an email. Thus far, the reaction in the research community has been positive, he added. 

Throughout the review process, the researchers encountered natural skepticism.

“It remains to be determined how the findings we put forward hold when mice are engaged in odor trigger behavior” as odors are associated with particular meaning such as a reward, an lead to specific actions,” Albeanu explained. “This is what we are currently doing.”

Albeanu added that a few different streams of information may be supported by tufted and mitral cells, depending on the needs of the moment.

Arkarup Banerjee. Photo ciourtesy of CSHL

The study that led to this work started when Banerjee was a PhD student in Albeanu’s lab. Albeanu said that a postdoctoral fellow in his lab, Honggoo Chae, provided complementary work to the efforts of Banerjee in terms of data acquisition and analysis, which is why they are both co-first authors on the study.

For Banerjee, the work with these olfactory cells was an “echo from the past,” Albeanu added. 

As for where the research goes from here, Albeanu said future questions and experiments could take numerous approaches.

Researchers are currently looking for markers or genes that are expressed specifically and differentially in mitral or tufted cells and they have found a few potential candidates. While some markers have been found, these do not sharply label all mitral only versus all tufted cells only.

One of the confounding elements to this search, however, is that these cells have subtypes, which means that not every mitral cell has the same genetic blueprint as other mitral cells.

Another option is to inject an agent like a virus into the piriform cortex and assess whether boosting or suppressing activity in that region in the midst of olfaction alters the behavioral response.

Additionally, researchers could use tools to alter the activity of neurons during behavior using optogenetic approaches, inducing or suppressing activity with cell type specificity and millisecond resolution.

Albeanu would like to test speculation about the roles of these cells in action, while a mice is sampling smells he presents.

By observing the reactions to these smells, he could determine an association between rewards and punishment and anything else he might want to include.

The upshot of this study, Albeanu said, is that an objective observer would have much less trouble extracting information about the identity and intensity of a smell from a tufted cell as compared with a mitral cell.

Tufted cells had been “slightly more mysterious” up until the current study.

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Pixabay photo

By Daniel Dunaief

Daniel Dunaief

I’ve been on a long journey that’s taken me around the world for more than two and a half years. Many hosts have provided for me, enabling me to grow and, in some cases, make changes.

I don’t recall the beginning. The first host I remember was an incredibly kind doctor. She spent countless hours caring for others, looking into their eyes, assuring them she would do everything she could for them.

She was so focused on helping others that she didn’t even know she was hosting me. I stayed quiet just long enough to make the jump to a famous American actor who was working in Australia.

He and his wife didn’t enjoy their time with me. They warned the world about me and my extended family.

My next host was a businessman. He had been in a hospital with his son, who had a broken leg. The businessman stayed in the waiting room for hours, trying to do his work but unable to focus because he was so concerned about his boy.

Finally, after hours of surgery, the doctor came out to talk to him and that’s when I found a new host.

This businessman worked hard. Once he discovered his son was safe, he ignored me and my needs.

I developed without anyone noticing me. At one point, I heard someone come looking for me, but I hid just far enough away. I traveled a great distance on a plane with him. Once we were in a new country, I had so many choices.

Realizing it was time to go, I jumped to an elderly bus driver. He was a gentle man. The lighter laugh lines near his eyes looked like waves approaching the shore on his dark chocolate skin.

Before he collapsed into bed the second evening we were together, he seemed to be staring directly at me. In his house, I had a choice of other possible hosts, but decided to hitch a ride with his son.

That one almost cost me my life. His son soon realized I was there, and he stayed away from everyone. I was curled up alone with him. He barely moved for long periods of time, except when he coughed or sat up and sent text messages and emails. One night, when he was finally sleeping, a man came into his room to clean it. That’s when I escaped.

This man didn’t even know he hosted me. He wasn’t stuck in bed, and he didn’t cough. I traveled with him to several events. After other trips, I found an important politician. We took a ride in a helicopter and went to a hospital where doctors provided all kinds of new medicines.

I became like a game of telephone, passing along from one person to the next. And, like a game of telephone, the message changed, as I demanded different things from my host.

I found myself at a concert with a young woman who sang and danced for hours. She looked so vibrant and full of life.

She was a friendly enough host, until I set up camp with her mother. Then, she shouted at me, praying to keep me away. She took me to a hotel, where she seemed to stare at me while she prayed.

When someone delivered food and walked in the room to wait for payment, I made the jump to him. During the day, he was a student with a full and busy life. I didn’t stay long, moving on to his girlfriend, her roommate, and, eventually, to a professor.

I stayed with the professor for over a week. She spent considerable time grading papers, writing at her computer, talking to family members, and taking medicine.

I have made some changes along the way. I don’t travel with as much baggage as I used to. I know people think I’m not as much of a burden as I was in the early days. My most recent host would disagree. He couldn’t talk, had trouble sleeping and was exhausted all the time. I’m getting ready to travel the world again this fall and winter. You can ignore me all you want, but I’m still here, making changes and preparing to find more hosts.

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Mercy Baez. Photo by Joseph Rubino/ BNL

By Daniel Dunaief

She is a greeter, a corporate concierge, a facilitator, a point of contact for people traveling thousands of miles, a Spanish translator, an important contact in case of emergencies, and whatever else visitors need.

While Mercy Baez, who was promoted to User Program Coordinator for the National Synchrotron Lightsource II and the Laboratory for BioMolecular Structure at Brookhaven National Laboratory early in October, wears many hats, one of the only ones she doesn’t wear is scientist, although that doesn’t keep her from appreciating and taking pride in the research conducted at the Department of Energy facility.

“We’re helping them and they are helping the world,” Baez said.

BNL has a steady stream of users who apply for time at the various research facilities at the national laboratories. 

Baez is specifically responsible for providing a wide range of support and services to the NSLS II and the LBMS. Users, which is how BNL describes potential visiting scientists who conduct research at the lab’s facilities, submit proposals to her office, which then distributes them to a proposal review panel.

When visiting scientists learn that their work, which includes monitoring batteries as they function and searching for fine structural sites in the molecular battle against pathogens, has earned a high enough score to receive coveted time on the lab’s instruments, they prepare for their visit by interacting with Baez and her current team of four by getting registered and approved for access.

Baez offers soup to nuts guidance that often also includes helping users literally find soup, nuts and numerous other items. Baez ensures that users take any necessary training courses, provides guidance regarding registering for on site access to BNL, provides information on the steps or items necessary when they arrive, helps find nearby hotels, coordinate travel to and from the lab and, if necessary, secures places to stay if they miss their planes, get snowed in or have other unforeseen changes in their schedules.

As of October 1st, visitors also have to have some type of active shooter training to access the lab’s facilities. Currently, users are required to take five training courses. Last week, the lab decided to incorporate active shooter training into one of these other training courses.

The lab has always had routine emergency training courses and drills for lab employees. With the changing times and current events, the lab is looking to equip users for such emergencies. The lab hopes never to have to use this training, but if such an event occurs, staff and users will know how to handle such a situation.

In addition to training to help users prepare to visit the facility, Baez provides visitors with a host of on site facilities, including adaptors in case they are using European electronics that don’t connect with the outlets, laptops in case the computer a scientist brought isn’t working, conference rooms for impromptu meetings, and dorm rooms for a respite while running time-intensive experiments.

BNL hosts employee resource groups including the African American Advancement Group, the Asian Pacific American Association, the Brookhaven Veterans Association, Brookhaven Women in Science, the Early Career Resource Group, the Pride Alliance and the Hispanic Heritage Group. Baez said the lab tries to involve users and visitors in as many cultural and social events as possible, which include outings to dinners, plays and cultural virtual cooking classes.

In September, Baez participated in the Port Jefferson Dragon Boat Race Festival which the Asian Pacific  American Association sponsored. 

Baez, whose mother is from Puerto Rico and whose father is from Ecuador, is a member of the Hispanic Heritage Group.

A people person

A member of the user offices since 2003, Baez had recently been responsible for coordinating conferences, workshops, and training courses, including financial and logistical aspects of the events for NSLS-II and the LBMS. She had been functioning as the user program coordinator since January, when Gretchen Cisco retired. Baez feels fortunate to have worked with Cisco since she joined NSLS in 2005.

A self-described “people person,” Baez said she loves the opportunity to interact with scientists from all over the world. She particularly appreciates the chance to get to know about other cultures and has added destinations to her travel itinerary from speaking with visitors. She is hoping to travel to Morocco and Peru next year and is hoping to travel to Japan and a few other countries in the near future.

Coming from a Latina family that tends to be loud and outspoken and whose family gatherings often includes more than 30 people, she has learned to speak in a softer voice, particularly with people from other cultures or backgrounds.

She also has a tendency to speak quickly and has learned to slow the pace down so visitors who haven’t interacted with her can understand what she’s saying.

A resident of Medford, which is a ten-minute drive from the lab, Baez has a son Xzavier and a granddaughter Francesca. She is excited for the upcoming arrival of her second granddaughter in November.

When she’s not at the lab, she uses her leisure time to go hiking, fishing and camping.

With her then teenage son in tow, she went to the jungle of Belize for a survival course, where they learned how to catch their own food, build shelters, and harpoon fish. She also learned which plants are safe to eat and which are poisonous.

While her work responsibilities can be hair-raising, particularly in emergencies, she “loves the feeling that I was able to help a scientist, whether to get him or her on site or in an emergency,” she said. Knowing that she’s a part of making all this science happen makes her day and job rewarding, she said.

Baez has had some requests from scientists who have wanted cultural foods, such as Turkish or vegan dishes, that might be harder to find, particularly during off hours.

Around Thanksgiving each year, some visitors have asked if they can hunt wild turkeys at BNL, which is located within the Pine Barrens and has turkeys and deer wandering on site. She has told those users that the lab does not allow hunting.

Hunting aside, Baez said she is “here to help [users] do what they need to do.”

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METRO photo

By Daniel Dunaief

Daniel Dunaief

In tougher days before our son had a driver’s license and I had to pick him up from school, I brought the dog in the car. I’d see my son walking from school, head down, shoulders slumped, with the equivalent of a teenage angst enveloping him.

He’d get to the car, ready to throw himself into the seat next to me, to tell me his day was “fine” or that he “didn’t want to talk about anything,” and then he’d see the dog, wagging and prancing in the back seat and he was helpless against such charm and unbridled joy.

Our dog would throw his head into his hands, letting our son know that anything and everything our son did, particularly when he pet our dog’s ears, was welcome and appreciated.

While I know many people love puppies, with their fluffy fur and their playful demeanor, I have become increasingly attached and fond of our dog as he has aged.

And, as my wife has said, the feeling appears to be mutual.

When he was younger, our dog rarely came when I called him. He seemed fine with my petting him, but he didn’t go out of his way to get up from a comfortable nap.

But, then, something happened in the last year. Maybe it’s because we’ve traveled to visit family and friends for weddings and we haven’t taken him on each of our trips, or because he suddenly figured out that I feed him, provide water and take him for his necessary walks.

Whatever the case, he’s as happy to see me as I am to see him. At the same time, he’s become increasingly sensitive to the stress I’m feeling. When I get off the phone after an exasperating call with a customer service representative, he comes wagging over as if to say, “Yeah, that was annoying, but you’ll be fine and I’m still incredibly soft. Don’t you want to check?”

Recently, I contracted COVID-19. My wife, who hasn’t been feeling too well herself, took incredible care of me, picking up food and medicine while I shivered in bed and struggled to swallow through the razor blades dangling in the back of my throat.

In addition to the necessary and helpful support from my wife and brothers, I received encouragement from our dog, who seemed to recognize something was amiss. He came to the side of the bed and leaned his head into my hand. He put his paw up near my arm as well, wagging cautiously and looking into my eyes.

He reminded me of our dog from my childhood. Also, a golden retriever, our earlier dog raced to the kitchen door to be let out (yes, that was a different time). He used to return when he was ready and after he’d visited the neighbors and tended to his physical needs.

In my junior year of high school, I developed a migraine that limited my ability to see and gave me a horrific headache. At the same time, all physical contact was uncomfortable, from my friend touching my hand to guide me to the nurse to my mother escorting me to the car.

When I returned home, I lay in a dark room, miserable under the searing pain. The dog, who wasn’t used to having me home during the day, stayed in my room all day. He didn’t move or make a sound and, more amazingly, he never tried to touch my hand.

He finally went outside after I got up and felt better. He stood guard all those years ago, just as our pets do now, protecting us against strangers and offering support in our lowest and most emotionally vulnerable moments.

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Pixabay photo

By Daniel Dunaief

Daniel Dunaief

My grandmother was a worrier. 

Even she, however, would have had a hard time worrying about other major challenges, problems and threats during the worst of the COVID-19 pandemic.

That, it turns out, was also true for the world during COVID when it came to discussions about the threat from climate change.

In a recent study published in the prestigious journal Proceedings of the National Academy of Sciences, Oleg Smirnov, associate professor in the Department of Political Science at Stony Brook University, examined the level of concern on Twitter about climate change during 2020 and 2021 and compared those numbers to 2019, the last year before COVID.

According to the pool of finite worry, which Princeton professor of Psychology Elke Weber developed, environmental and climate concerns decline amid worries about other major threats.

Smirnov found that the total number of tweets that mention climate change dropped to 5.6 million in 2020 and 5.3 million in 2021, from 8 million in 2019. This, Smirnov points out, occurred despite an increase in Twitter users, more climate disasters and more climate news in 2021.

“The psychological foundation tell us that people may only really respond to one threat at a time,” Smirnov said in an interview. The anxiety and the reaction to that threat may be limited because it requires major energy.

“Maybe, for biological reasons, [people] put all their energy into responding to the most immediate threat,” Smirnov added.

By tracking daily tweets and various measures of COVID cases, Smirnov found on a finer scale as well that discussions of climate change diminished amid higher infections and mortality.

For every thousand new COVID-19 cases in the United States, climate change tweets decreased by about 40.5 tweets per day. Every thousand new deaths resulted in 3,308 fewer climate tweets.

While Smirnov understood the need to focus on the pandemic, he suggested a lack of concern about climate change could disrupt efforts to protect the planet

“This has profound implications,” Smirnov said. “Without a focus on climate change, without an emphasis on its importance, there is less urgency and less pressure on politicians to do something about it.”

Even in better times, climate change efforts are “fragile,” he said, which adds to the uncertainty about the ability to address the challenge adequately.

Indeed, even the sentiment analysis, in which Smirnov reviewed the emotional content of words used to describe climate change and the threat to the planet and humanity, became less negative during the worst of the pandemic.

When asked about the possibility that climate change concerns might have declined during COVID in part because the carbon footprint declined amid travel restrictions and slowdowns in industrial production, Smirnov likened such an approach to short-term fasting or extreme dieting.

While spending a few days on these extreme diets can reduce a person’s weight over the course of days, such an approach provides “no substantial improvement in your health” longer term, he said.

So, what about now, as concerns about the pandemic abate, people have stopped wearing masks and schools and stadiums are full?

Smirnov plans to continue to collect Twitter data for the remainder of this year, to see whether a return to normalcy brings the focus back to the threat from climate change.

As for his own experience, Smirnov recognized that climate change took a back burner amid the worst of the pandemic.

“My attention certainly was hijacked by COVID-19, despite the fact that climate change is part of my work,” Smirnov said. In April of 2020, Smirnov recalled worrying about where his family would find food instead of thinking about greenhouse gases and rising sea levels.

In the present, Smirnov remains concerned about the kind of tipping points and climate inertia that threatens the future.

Ever the worrier, my grandmother might be relieved enough by the less virulent form of the virus and the availability of vaccines and treatment to return to worrying about the threat climate change poses.

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From left, K. Barry Sharpless and John Moses. Photo from CSHL

By Daniel Dunaief

K. Barry Sharpless changed John Moses’s life. And that’s before Moses even started working as a postdoctoral researcher in Sharpless’s lab.

When Moses, who is the first chemist to work at Cold Spring Harbor Laboratory in its 132-year history, was earning his PhD in chemistry at Oxford, he read an article that Sharpless co-authored that rocked his world.

Nicknamed the “click manifesto” for introducing a new kind of chemistry, the article, which was published in Angewandte Chemie in 2001, was “one of the greatest I’ve ever read,” Moses said, and led him to alter the direction of his research.

Moses walked into the office of the late chemist Sir Jack Baldwin at Oxford, who was Moses’s PhD advisor, and announced that Sharpless, a colleague of Baldwin’s at the Massachusetts Institute of Technology, was the only chemist he wanted to work with in the next phase of his career.

Baldwin looked at Moses and said, in a “very old-fashioned gangster English, ‘That shows you’ve got some brains,’” recalled Moses.

Sharpless was important not only to Moses’s career, but also to the world.

Recently, Sharpless, who is the W.M. Kepp Professor of Chemistry at Scripps Research, became only the fifth two-time recipient of the Nobel Prize.

Sharpless will share the most recent award, which includes a $900,000 prize, with Carolyn R. Bertozzi, the Anne T. and Robert M. Bass Professor in the School of Humanities and Sciences at Stanford University, and Morten P. Meldal, professor at the University of Copenhagen, for the invention of a type of chemistry that has implications and applications from drug discovery and delivery, to making polymers, to developing anti cancer treatments.

The way click chemistry works is that chemists bring together catalysts and reagents, often attached to sulfur or carbon, that have a high level of specific attraction for each other. The click is like the sound a seat belt makes when secured, or the click a bike helmet lock makes when the two units are connected.

Scientists have often described the click reaction as being akin to LEGO blocks coming together, with an exact and durable chemical fit.

Natural product synthesis is generally challenging and often requires complex chemistries that are not always selective. This type of chemistry can produce side reactions that create unwanted byproducts and require purification.

Click reactions, by contrast, are selective and reliable and the products are generally easy to purify. Sometimes, purification is as simple as a water wash.

“It’s a democratization of synthetic chemistry,” Moses said.

Moses said biologists have performed click reactions. Chemists have developed click tablets that can be added to a reaction to create a plug and play system.

Moses described the reactions in click chemistry as “unstoppable” and suggested that they are part of a “domino rally” in which a latent build up of reactivity can create desired products with beneficial properties.

Moses, who arrived at CSHL in 2020, has collaborated with several researchers at the famed lab. He is submitting his first collaborative paper soon with Dr. Michael Lukey, who also started in 2020 and performed his PhD at Oxford, and Dr. Scott Lyons. He is also working on a New York State Biodefense funded project to create shape shifting antibiotics that can keep up with drug resistance pathogens. 

He has collaborated with Cancer Center Director David Tuveson to develop a new ligand to target a protein important in pancreatic cancer. Moses said they have a “very exciting” lead compound.

Early resistance

While the Nobel Prize committee recognized the important contribution of this approach, the concept met with some resistance when Sharpless introduced it.

“When [Sharpless] submitted this, the editor called colleagues and asked, ‘Has Barry gone crazy?’” Moses said.

Some others in the field urged the editor to publish the paper by Sharpless, who had already won a Nobel Prize for his work with chirally catalyzed oxidation reactions.

Still, despite his bona fides and a distinguished career, Sharpless encountered “significant resistance” from some researchers. “People were almost offended by it” with some calling it “old wine in new bottles,” Moses said.

In 2007, Moses attended a faculty interview at a “reasonably good” university in England,. where one of his hosts told him that click chemistry is “just bulls$#t!”

Moses recognized that he was taking a risk when he joined Sharpless’s lab. Some senior faculty advised him to continue to work with natural product synthesis.

In the ensuing years, as click chemistry produced more products, “everyone was using it and the risks diminished quickly,” Moses added.

Unique thought process

So, what is it about Sharpless that distinguishes him?

Moses said Sharpless’s wife Janet Dueser described her husband as someone who “thinks like a molecule,” Moses said.

For Moses, Sharpless developed his understanding of chemistry in a “way that I’ve never seen anyone else” do.

Moses credits Dueser, who he described as “super smart,” with coining the term “click chemistry” and suggested that their partnership has brought together his depth of knowledge with her ability to provide context.

Moses believes Sharpless “would admit that without [Dueser], his career would have been very different! In my opinion, [Dueser] contributed immeasurably to click chemistry in so many ways.”

Indeed, click chemistry won a team prize from the Royal Society of Chemistry last year in which Dueser was a co-recipient.

As for what he learned from working with a now two-time Nobel Prize winner, Moses said “relinquishing control is very powerful.”

Moses tells his research team that he will never say “no” to an innovative idea because, as with click chemistry, “you never know what’s around the corner.”

Moses said Sharpless is a fan of the book “Out of Control” by Kevin Kelly, the co-founder of Wired Magazine. The book is about the new biology of machines, social systems and the economic world. Sharpless calls Kelly “Saint Kevin.”

On a personal level, Sharpless is “humble and a nice person to talk to” and is someone he would “want to go to a pub with.”

Moses believes Sharpless isn’t done contributing to chemistry and the world and anticipates that Sharpless, who is currently 81 years old, could win another Nobel Prize in another 20 years.

An inspirational scientist, Sharpless ” is “that kind of person,” Moses said.

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Peter Westcott, on right, in the lab with technicians Zakeria Aminzada, on left and Colin McLaughlin, center. Photo by Steven Lewis

By Daniel Dunaief

When Peter Westcott was growing up in Lewiston/Auburn, Maine, his father Johnathan Harris put the book “Human Genome” on his bed. That is where Westcott, who has a self-described “obsessive attention to detail,” first developed his interest in biology.

Westcott recently brought that attention to detail to Cold Spring Harbor Laboratory, where he is an assistant professor and Cancer Center member. He, his wife Kathleen Tai and their young children Myles and Raeya moved from Somerville, Massachusetts, where Westcott had been a postdoctoral fellow at the Koch Institute of Integrative Cancer Research at the Massachusetts Institute of Technology.

Westcott will take the passion and scientific hunger he developed and honed to the famed lab, where he plans to continue studies on colon cancer and the immune system.

“A lot of things attracted me to Cold Spring Harbor Laboratory,” said Westcott who had been to the lab during conferences, joining three Mechanisms and Models of Cancer meetings, and appreciated that the small size of the lab encourages collaboration and the sharing of ideas across disparate fields.

At this point, Westcott, who purchased a home in Dix Hills and started on campus on September 1st, has two technicians, Zakeria Aminzada and Colin McLaughlin working with him. He will be taking on a graduate rotation student from Stony Brook University soon and would also like to add a postdoctoral researcher within about six months. He plans to post ads for that position soon. 

Research directions

Westcott said his research has two major research directions.

The first, which is more translatable, involves looking at how T cells, which he described as the “major soldiers” of the immune system, become dysfunctional in cancer. These T cells balance between attacking unwanted and unwelcome cells relentlessly, disabling and destroying them, and ignoring cells that the body considers part of its own healthy system. When the T cells are too active, people develop autoimmunity. When they aren’t active enough, people can get cancer.

“Most cancers, particularly the aggressive and metastatic ones, have disabled the immune response in one way or another, and it is our focus to understand how so we can intervene and reawaken or reinvigorate it,” he explained.

During cancer development, T cells may recognize that something on a tumor is not healthy or normal, but they sometimes don’t attack. Depending on the type of genetic program within the T cells that makes them tolerant and dysfunctional, Westcott thinks he can reverse that.

A big push in the field right now is to understand what the genetic programs are that underlie different flavors of dysfunction and what cell surface receptors researchers can use as markers to define T cells that would allow them to identify them in patients to guide treatment.

Westcott is taking approaches to ablate or remove genes called nrf4a 1, 2 and 3. He is attacking these genes individually and collectively to determine what role they play in reducing the effectiveness of the body’s immune response to cancer.

“If we knock [some of these genes] out in T cells, we get a better response and tumors grow more poorly,” he said.

Westcott is exploring whether he can remove these genes in an existing T cell response to cause a regression of tumor development. He may also couple this effort with other immunotherapies, such as vaccines and agonistic anti-CD40 antibody treatment.

As a second research direction, Westcott is also looking more broadly at how tumors evolve through critical transitions. Taking an evolutionary biology perspective, he hopes to understand how the tumors start out as more benign adenoma, then become malignant adenocarcinoma and then develop into metastatic cancer. He is focusing in particular on the patterns of mutations and potential neoantigens they give rise to across the genome, while concentrating on the immune response against these neoantigens.

Each tumor cell is competing with tumor cells with other mutations, as well as with normal cells. “When they acquire new mutations that convey a selective advantage” those cells dominate and drive the growth of a tumor that can spread to the rest of the body, Westcott said.

Using a mouse model, he can study tumors with various mutations and track their T cell response.

T cells tend to be more effective in combating tumors with a high degree of mutations. These more mutated tumors are also more responsive to immunotherapy. Westcott plans to study events that select for specific clones and that might shift the prevalence, or architecture, of a tumor.

Some of the work Westcott has done has shown that it is not enough to have numerous mutations. It is also important to know what fraction of the cancer cells contain these mutations. For neoantigens that occur in only a small fraction of the total cells in the tumor, the T cell responses aren’t as effective and checkpoint blockade therapy doesn’t work.

He wants to understand how the T cell responses against these neoantigens change when they go from being subclonal “to being present in most or all of the tumor cells,” he explained. That can occur when a single or few tumor cells acquire a selective advantage. His hypothesis is that these selective events in tumor progression is inherently immunogenic. \

By exploring the fundamental architecture of a tumor, Westcott hopes to learn the mechanisms the tumor uses to evade the immune system.

Ocean breeze

As Westcott settles in at CSHL, he is excited by the overlap between what he sees around the lab and the Maine environment in which he was raised.

“Looking out the window to the harbor feels like New England and Maine,” he said. “It’s really nostalgic for me. Being near the ocean breeze is where I feel my heart is.”

Before his father shared the “Human Genome” book with him, Westcott was interested in rocks and frogs. In high school, his AP biology teacher helped drive his interest in the subject by encouraging discussions and participation without requiring her students to repeat memorized facts. The discussions “brought to life” the subject, he said.

As for his work, Westcott chose to study colon cancer because of its prevalence in the population. He also believes colon cancer could be a model disease to study all cancers. By understanding what differentiates the 12 percent of cases that are responses to immunotherapy from the remainder that don’t respond as well to such approaches, he hopes to apply these lessons to all cancer.

“There is a huge, unmet need,” he said.

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