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136 students comprise the RSOM Class of 2027, shown here reciting the Hippocratic Oath.
New RSOM student Jasmine Stansil (center), with her parents and grandparents at the school’s White Coat Ceremony.
Dean Peter Igarashi, MD
Adam Bruzzese wearing his first white coat after receiving from Andrew Wackett, MD, Vice Dean of Undergraduate Medical Education.

136 students launch journey into Medicine at traditional White Coat Ceremony

At the Renaissance School of Medicine’s (RSOM) White Coat Ceremony, 136 incoming students donned their physician “white coats” and took the Hippocratic Oath for the first time. Held at Stony Brook University’s Staller Center, the annual ceremony brings students, their families, and faculty together as the academic year begins and members of the Class of 2027 embark on their journeys toward becoming physicians. The RSOM has held the White Coat Ceremony since 1998.

The incoming students are a select group, and according to RSOM administrators is one of the most diverse classes in the school’s history. Only 8.5 percent of all applicants to the RSOM for 2023-24 were accepted into the program. Approximately 20 percent of class consists individuals from historically marginalized communities, and 54 percent of the class are women.

Collectively the students received their undergraduate degrees from 66 different colleges and universities from around the country. Stony Brook University (20) and Cornell University (17) were the undergraduate schools with the most representation. The class has a combined median undergraduate GPA of 3.89. While many of the new students are from different areas of the country, 77 percent hail from New York State.

“To the Class of 2027, you are entering medicine at an exhilarating time,” said Peter Igarashi, MD, Dean of the RSOM, who presided over his first White Coat Ceremony. “Scientific discoveries in medicine are occurring at a breathtaking and awe-inspiring rate. Diseases that were rapidly fatal when I was a medical student, such as multiple myeloma and leukemia, are now routinely treated. Advances in human genetics have enabled truly personalized medicine, and the development of an effective Covid-19 vaccine less than one year after the onset of the pandemic saved almost 20 million lives and underscored the essential role that science plays in public health.”

All of the students have a story as to how and why they have chosen Medicine as a profession.

For New York City native Adam Bruzzese, an NYU graduate, his family’s difficulties and challenges they had within the healthcare system was a big trigger to increasing his passion for medicine. Adam’s 11-year-old sister had mysteriously become paralyzed, and he played an integral part in providing her healthcare as a teenager and college student. He witnessed disparities of care as she moved through the health system, plus the myriad  of tests and physician opinions along the way. It was eventually determined her paralysis was caused by Lyme Disease.

Manteca, California native Jasmine Stansil, a standout student in high school and at the University of California, San Diego, was always fascinated by the human body as a kid. She also became captivated by how physicians can have an incredible impact on human life when she watched Untold Stories of the ER. But she was most inspired to pursue Medicine because of her grandmother, who endured multiple strokes.

“Watching doctors provide her care made me want to do the same for others,” says Stansil. “I am hoping to become an academic physician who will provide clinical care, teach and conduct research.”

Jerome Belford, one of the 20 class members who attended Stony Brook University as an undergraduate, described his interest in medicine as coming from a “passion that stems from a desire to promote physical and emotional health and wellness.”

From Long Island, Belford is a volunteer EMT who decided to attend the RSOM because of its broad research and clinical opportunities and standout education that provides experiential and hands-on medical training. He hopes to eventually provide patients who have historically not had access to the best medical resources improved care, either as an emergency physician or though primary care as an internist.

White coat ceremonies are an initiation rite and are symbolic to Medicine as a profession that combines professionalism with scientific excellence and compassionate care. In an era of telemedicine, aging populations, new knowledge about infections and diseases, and emerging technologies, Medicine remains a dynamic and changing profession that continues to impact the health and well-being of society.

All photos by Arthur Fredericks

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Represented in this illustration is the authors’ finding that DNA hypermethylation disrupts CCCTC-binding factor (CTCF) mediated boundaries which in turn lead to aberrant interactions between an oncogene and an enhancer, driving hyperproliferation and subsequently tumorigenesis from normal OPCs. Photo by William Scavone/Kestrel Studio

Study in Cell led by Stony Brook researcher provides unique analysis in a glioma model

Gliomas are incurable brain tumors. Researchers are trying to unlock the mysteries of how they originate from normal cells, which may lead to better treatments. A new study published in the journal Cell centers on epigenetic rather than genetic changes that drive normal cells to form tumors. The work reveals the precise genes that are regulated epigenetically and lead to cancer.

Genes make us who we are in many ways and are central to defining our health. Cancer is often viewed as a disease caused by changes in our genes, thus our DNA. Epigenetics is the study of how behavior, environment, or metabolic changes can cause alterations to the way genes work. Unlike genetic changes, epigenetic changes do not change one’s DNA, and they can be reversed.

“We used tumor samples and mouse modeling to discover and functionally demonstrate the role of epigenetic alterations in gliomas,” says Gilbert J. Rahme, PhD, first author and Assistant Professor in the Department of Pharmacological Sciences at the Renaissance School of Medicine, and formerly a postdoctoral fellow at the Dana-Farber Cancer Institute in Boston. “By doing this, we discovered genes regulated epigenetically in gliomas, including potent tumor suppressor genes and oncogenes, that drive the tumor growth.”

In the paper, titled “Modeling epigenetic lesions that cause gliomas,” the research team show in the model that epigenetic alterations of tumor suppressor and oncogenes collaborate together to drive the genesis of this brain tumor.

The authors explain that “epigenetic activation of a growth factor receptor, the platelet-derived growth factor receptor A (PDGFRA) occurs by epigenetic disruption of insulator sites, which act as stop signs in the genome to prevent aberrant activation of genes. The activation of PDGFRA works in concert with the epigenetic silencing of the tumor suppressor Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) to transform a specific cell type in the brain, the oligodendrocyte progenitor cell (OPC), driving the formation of brain tumors.”

Rahme says the next step is to test whether therapies that can reverse the epigenetic changes observed in brain tumors can be helpful as a treatment.

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The Atlantic horseshoe crab. Public domain photo

From the shore, they can look like odd-shaped shadows with tails, moving in and out of the surf or approaching the shoreline.

Up close, they can have a collection of barnacles attached to their shells, particularly as they age.

Horseshoe crabs, who have been roaming the oceans for over 450 million years, have attracted the admiration of researchers and the dedication of volunteers around Long Island, who not only want to ensure they continue to survive, but also would like to know more about creatures that are more related to spiders and scorpions than to the crabs their names suggest.

“One of the things we’re trying to do is look at spawning in a more comprehensive way,” said Robert Cerrato, a professor in the School of Marine and Atmospheric Sciences at Stony Brook University. “We’re trying to figure out if there are specific things that [horseshoe crabs] are responding to” when they come up on the beach to lay their eggs.

A closeup of two horseshoe crabs. Photo courtesy Matthew Sclafani

Horseshoe crabs have had a steady decline in their population over the last 20 years overall. In the last three to five years, however, not much has changed in the Long Island area, scientists explained.

The population is “still very similar to where it was,” said Matthew Sclafani, senior resource educator at Cornell Cooperative Extension of Suffolk County and assistant adjunct faculty member at SBU.

Scalafani and Cerrato have worked together for well over a decade and are hoping to address a wide range of questions related to these unusual creatures that have nine eyes and blue blood.

Apart from the fascination of scientists and volunteers, the horseshoe crab provides a critical food source for shore birds like the Red Knot, which depends on these eggs during their migration.

At the same time, horseshoe crabs and their blue blood provide a key ingredient in tests of pharmaceuticals. When exposed to endotoxins, horseshoe crab blood forms clots.

The use of horseshoe crab blood to test drugs does not occur in New York, however, as companies don’t catch these creatures in the Empire State for this specific test.

Cerrato and Scalafani explained that numerous towns have also limited or banned the harvesting of horseshoe crabs to maintain their local populations.

Areas around West Meadow Beach in Old Field, for example, are closed to hand harvesting, as is Jamaica Bay and Gateway National Recreation Area.

Such policies “theoretically will allow for more eggs on the beach to hatch and for shore birds dependent on them” to find food, Sclafani said. Such closures, including some during the last two weeks in May and the first two weeks in June during the peak spawn were “significant steps for conservation,” Sclafani added.

An aerial photograph taken by a drone during a horseshoe crab survey at Pike’s Beach, Westhampton. Photo by Rory MacNish/Cornell Cooperative Extension of Suffolk County

Ongoing questions

By labeling and tracking horseshoe crabs, these researchers and a team of volunteers hope to understand whether crabs, which are capable of reproducing when they are between 8 and 10 years old, return to the same sites each year to lay their eggs.

Cerrato and Scalafani are hoping to get satellite tags they can attach to adults, so that when they come out of the water to spawn, researchers know their location.

The researchers submitted a proposal to the New York State Department of Environmental Conservation to do a pilot study with these satellite tags.

Juvenile horseshoe crabs also present unknowns, as they have a different diet and migrate at a much lower rate.

“We started to look at” crabs that are 3 to 10 years old, said Cerrato. Moriches Bay is an “important habitat” for them.

Volunteer passion

Volunteers who help count the horseshoe crabs count these creatures often until well after midnight.

Frank Chin has been wandering beaches, counting crabs for 15 years. When he was young, Chin wanted to be a forest ranger.

“I realized that forest rangers don’t make that much money, so I went to school for engineering, got a degree and worked as an engineer,” he said.

Chin found himself at a Friends of Flax Pond meeting, where Scalafani asked for help from the community.

“I foolishly raised my hand and they made me a coordinator,” joked Chin, who counts horseshoe crabs with his wife Phyllis.

Every year presents something new to Chin.

This year, he has run into people who fish late at night. Chin said the fishermen, who have permits, are cordial, but that he’s concerned they might be scaring crabs away from their usual spawning spots.

In addition to counting the crabs, Chin, who is the director of the lab in the Physics Department at SBU, also tags them. He once caught a crab seven years after he initially tagged it.

Chin, who will count crabs in the rain but not in thunderstorms, appreciates the dedication of his fellow volunteers, who not only count the crabs but will pick up garbage and bottles along the beach.

Chin plans to continue to “do it as long as I can walk down the beach.” Some day, he “hopes someone else will take over.”

Volunteers can sign up to join the effort at nyhorseshoecrab.org.

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By Daniel Dunaief

A problematic atmospheric greenhouse gases, methane comes from natural gas, agriculture, and swamps. 

John Mak

Recently, John E. Mak, a Professor in the School of Marine and Atmospheric Sciences at Stony Brook University worked with an international group of scientists to demonstrate a process that removes methane from the atmosphere.

A mixture of dust from the Sahara and sea spray reacts with methane to form carbon monoxide and a small amount of hydrochloric acid.

In a recent paper published in the prestigious journal Proceedings of the National Academy of Sciences, Mak, corresponding author Matthew Johnson, who is a Professor in the Department of Chemistry at the University of Copenhagen, and others showed how a novel process removes 5 percent, plus or minus 2 or 3 percent, of the methane from the atmosphere in specific areas.

“What we are showing is that some methane in the middle of the tropical Atlantic Ocean region may be removed” through this process, Mak said from the Gordon Research Conference on Atmospheric Chemistry in Sunday River, Maine.

The research validates a mechanism Mak had proposed in the late 1990’s, when he conducted studies funded by the National Science Foundation in Barbados. “When I first made the observations, I proposed that what we were seeing was a chlorine mediated removal of methane,” Mak explained.

At that time, he didn’t have the ability to make those measurements. The technology, however, has evolved over the years and researchers can now measure chlorine radical precursors such as Cl2 and other chlorine compounds.

Indeed, Maarten van Herpen, first author on the study and a member of Acacia Impact Innovation, approached Mak with a new theory and a new mechanism that he thought could explain Mak’s results from decades earlier.

“They were excited to hear that no one had solved the problem,” said Mak.

By working together through this international team, the group was able to take new measurements and utilize advances in their understanding of atmospheric processes.

‘New, but old’

Mak had conducted his studies towards the beginning of his time at Stony Brook University in the late 1990’s as a part of one of his first federally funded projects. 

“It’s a little unusual for people to make use of observations so far in the past,” said Mak. “It opens up a new, but old avenue of research.”

Mak, who is conducting studies in other areas including a recent project in New York to investigate air quality and air chemistry mechanisms specific to the greater New York City region, believes the research on this PNAS paper takes him almost full circle back to this earlier work.

“There’s a feeling of satisfaction that good measurements are useful for a longer period of time,” he said. 

In this study, Mak helped interpret some of the data his collaborators generated.

The reactions

The process of removing methane starts with sea spray, which is aerosolized by bubbles bursting at the contact point between the ocean and the air. The chlorine comes from that sea spray, while iron comes from the continental crust.

Saharan dust can traverse the globe, but scientists are not sure of the spatial extent of this process. They believe it could be throughout the tropical Atlantic, but it could be in other dust laden ocean regions in the Indian and Pacific Oceans as well.

That process creates what is described as a reactive chlorine species, which is on the hunt for a positively charged particle, such as one of the four hydrogen atoms attached to carbon in methane.

Once the chlorine removes a hydrogen, it creates a methyl group, or CH3, and an incredibly small amount of hydrochloric acid, or HCl, at about one part per quadrillion.

The acid, in fact, is so low that it doesn’t cause any acidification of the oceans. Ocean acidification primarily comes from the absorption of carbon dioxide gas, which reacts with seawater and eventually increases the amount of positively charged hydrogen atoms, decreasing the ocean’s pH.

Meanwhile in the atmosphere, the remaining methyl group is oxidized to carbon monoxide, which eventually becomes carbon dioxide. That is also a greenhouse gas, but is not as potent at trapping heat in the atmosphere as methane.

Now that the group has explored this process, Mak explained that the next step will involve proposing a field campaign in the tropical Atlantic with state of the art instruments.

Mak believes the journal PNAS likely found the subject matter compelling on a broader scale, particularly because this process affects weather and climate.

Outside work

When he’s not working, Mak enjoys boating and fishing. A native of Southern California, Mak is a commercial pilot, who also does some flying as a part of his research studies.

As for climate change, Mak suggested that the weather extremes from this year, which include record high temperatures in the ocean near the Florida Keys and high temperatures in areas in Arizona, are a part of a pattern that will continue.

“What we have been and will continue to observe are changes to the broad equilibrium of energy balance of the Earth ocean atmosphere system,” he explained. “There’s a lot of inertia in the system. But when you change the input by changing the forcing, you upset that equilibrium.” That, he explained, could alter the weather, which is generated as a response to differences in energy from one place to another.

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The Pediatric Infectious Diseases Group at Stony Brook Medicine’s new regional tick-borne disease center, located in the Hampton Bays Atrium. From left, Dr. Andrew Handel, Dr. Dalia Eid, Dr. Christy Beneri and Dr. Sharon Nachman. Photo from Stony Brook Medicine

Stony Brook University is planning to open the first and only dedicated tick clinic in the northeast on Monday.

Supported by doctors from Stony Brook Medicine’s Meeting House Lane Medical Practice and Stony Brook Children’s Hospital, the new regional tick-borne disease center, which is located in the Hampton Bays Atrium, will provide by-appointment treatment for children and adults for tick bites and diagnose tick-borne illnesses.

The timing could be especially important for people with tick bites, as the previous warm winter allowed more ticks and their eggs to survive.

“They are out there, happily laying eggs and the eggs will hatch,” said Dr. Sharon Nachman, chief of the Division of Pediatric Infectious Diseases at Stony Brook Children’s Hospital.

Brian Kelly of East End Tick and Mosquito Control donated the center’s suite which includes a reception area, two exam rooms, two private offices for consults and a nurse’s station, for 10 years.

“Between the beautiful weather in the winter and the nice weather in the summer, ticks are outside,” Nachman said. “I’m thrilled we’re doing it now. There’s no time like the present to move forward and work with the community to get this done.”

Tick checks

Health care providers urged parents, caregivers and anyone who spends quality time in nature to do regular tick checks.

Ticks can be so small that they look like a little freckle. These ticks can harbor diseases beyond the dreaded and oft-discussed Lyme Disease. Other diseases include babesiosis, ehrlichiosis and anaplasmosis.

In general, Nachman urged patients not to send ticks they pulled off themselves into the center.

“It’s the tick that they didn’t see that’s also putting them at risk,” she said. The clinic will determine the type of tests to run based on the symptoms.

For tick bites, as with many other health challenges, time is of the essence.

A tick that’s attached itself to a human for fewer than 48 hours likely won’t lead to an infection. Someone with a tick bite for about 48 hours might get a single dose of an antibiotic. People who had a tick bite for over that period might develop a rash or even facial palsy, in which one side of the face droops for an extended period of time.

Doctors work with patients to try to hone in on the date of a possible tick bite.

“We do pretty good guessing,” said Nachman. “We don’t need to be perfect: we need to be pretty close.”

Ticks are present throughout Suffolk County.

Health care workers urge people to spray their clothing with DEET. While ticks aren’t always easy to see, people can find them by feeling a new lump or bump on their skin.

Removing ticks

Nachman advised people to wipe an area with a tick down with alcohol before trying to remove an embedded insect.

Using a flat edged tweezer, the tick removers should grasp the insect and slowly back it out.

“Don’t grab the tick and yank,” Nachman cautioned. The mouth parts of the tick have an adhesive, which can leave some of the parts inside the infected person.

Nachman, who will be at the center on Mondays, also urged people not to use petroleum jelly or match sticks.

The hours at the center will adjust to the demand. In the winter, when ticks are less prevalent, the center may have more limited appointment times.

One of the advantages of the center is that the health care providers can track patients over time who have been infected.

Doctors can also sign patients up to become a part of a registry. By tracking people who have tick-borne infections, doctors might also address questions that are part of the science of diseases like Lyme.

“There may be better treatments or better tests” down the road, Nachman added.

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This graphic shows how per unit water saving by dry cooling increases carbon emissions by each power unit globally, a significant issue for example in areas of India. Qin et al., 2023. Nature Water

Study published in Nature Water suggests integrating planning may reduce carbon emissions in the future

Water scarcity and climate change is a threat to energy security, as carbon emission reduction from water and dry cooling of power plants remains a major challenge worldwide. An international collaboration of scientists including Gang He, PhD, of Stony Brook University, used global power plant data to demonstrate an integrated water-carbon management framework that bridges the gap to coupling diverse water carbon-mitigation technologies with other methods. Their findings are detailed in a paper published in Nature Water.

Thermal electric power generation uses substantial amounts of freshwater primarily for cooling of power plants, amounting to 40 to 50 percent of the total water withdrawal in the U.S. and 40 percent in Europe. Meanwhile, power generation accounted for approximately 36 percent of the energy-related carbon dioxide (CO2) emissions across world economies in 2019. The authors note that consequently, the power sector has a high dependence on freshwater resources and demonstrates intrinsic water-carbon interconnections that have critical implications on reliable electricity output and energy security, particularly under climate change.

In “Global assessment of the carbon-water tradeoff of dry cooling for thermal power generation,” they conclude such integrated planning is crucial to address the complex interactions between water and energy systems. The team constructed a global unit-level framework to assess the impact of dry cooling—a vital water mitigation strategy—alongside alternative water sourcing and carbon capture and storage (CCS) under different scenarios.

According to He, a co-author and Assistant Professor in the Department of Technology and Society at Stony Brook University, the research team collected unit-level power plant data, which included basic power generation unit information such as fuel and engine types, installed capacity, cooling technologies and other details. Then they estimated carbon emissions and water withdrawal based on what is known of emission factors at plants and water intensity by the cooling technologies, fuel types and local meteorology.

He says that from their global data the CO2 emission and energy penalty from dry cooling units were found to be location and climate specific, and ranged from 1 to 15 percent of power plant output. Additionally, efficiency losses were high under climate changes scenarios.

On a positive note, the team discovered potentially promising solutions to alleviate water scarcity around the power plants – such as increasing accessibility to wastewater and brine water that can provide viable alternatives to dry cooling and reduce energy and CO2 penalties.

Additionally, He and coauthors concluded that CCS emerged as a valuable tool to offset CO2  emission tradeoffs associated with dry cooling, especially when alternative water sourcing alone is insufficient in certain power plant regions.

However, He stresses that the issue is complicated globally, as CCS could demand more energy and thus more emissions, and wastewater could be useful but has its limitations and may not be available near some power plants.

The authors are concerned about the potentially increasing water-carbon tradeoffs with dry cooling.  They write: “Facing increasing water concerns, dry cooling has been and may continually be promoted as an emerging freshwater mitigation technique in some major economies in the next few decades along with renewable energy transitions.”

He says the research leading to the paper underscores the urgency of integrated power sector planning in the face of dual water-carbon challenges and “highlights the importance of considering climate-specific factors and interconnected systems to achieve sustainable energy solutions.”

The work was led by Dr. Yue Qin of Peking University. He’s research contributing to the paper findings is supported by the Global Energy Initiative at the ClimateWorks Foundation.

 

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JoAnne Hewett leads her first staff meeting as the new lab director at Brookhaven National Laboratory Tuesday, Aug. 8. Photo from BNL

In her first week on the job, JoAnne Hewett has been taking walks around campus — and she likes what she sees.

The first woman to lead the 76-year old Brookhaven National Laboratory, Hewett has explored a facility primarily funded by the Department of Energy that conducts groundbreaking research in Energy & Photon Sciences, Environment, Biology, Nuclear Science & Nonproliferation, Computational Sciences, Nuclear & Particle Physics and Advanced Technology Research.

The walks Hewett has taken have been “my way of learning where all the buildings are,” said Hewett in an exclusive interview with TBR News Media. “I truly love stumbling across things I didn’t know BNL had.”

One night, Hewett walked to an enormous greenhouse, which, as a gardener who enjoys growing tomatoes, chili peppers and citrus, intrigued her.

In meeting people at these facilities, Hewett has been “impressed” at “how dedicated they are to the mission and to the science that can be done here.”

Most recently the associate lab director for fundamental physics and chief research officer at SLAC National Accelerator Laboratory, Hewett brings extensive experience in theoretical physics to BNL and Stony Brook University, where she serves as Professor in the Department of Physics and Astronomy and Professor at the C.N. Yang Institute for Theoretical Physics.

Throughout her career, Hewett has been the first woman to serve in a host of roles. That includes as the first woman faculty member at SLAC in 1994, the first woman associate lab director and the first woman chief research officer.

“The best way to serve as a role model is to just do a good job at whatever it is you’re doing,” Hewett said.

In her many roles, Hewett has received numerous emails from students eager to meet her.

“Don’t get discouraged,” she tells them. “You’re going to get more roadblocks than others, potentially [but] hopefully not. Don’t get discouraged. Just keep working. If you love science and want to do science, if it’s the passion in your belly, just do it.”

Hewett has been successful in her career in part because she describes herself as “stubborn by nature.”

Cultural priorities

In her tenure as lab director for a facility with over 2,760 staff members, Hewett plans to emphasize the importance of creating a respectful work environment.

“It should be number one for everybody, everywhere to foster a respectful workplace environment, so that each person that comes into work in the morning or whenever they start their shift can do the very best that they can,” she said.

Additionally, she will stress the importance of safety at the Upton-based lab, where seven projects have led to Nobel Prizes.

“A good safety culture also promotes a good workplace environment,” said Hewett. “If you don’t do your work safely, you can’t do your work.”

Science vs. management

While research and management require the use of different parts of the brain, Hewett suggested her professional and administrative goals have overlapping approaches.

“In both cases, you need to be very strategic about your thinking,” she said. “When you’re doing research, you need to think about the best way to spend your time.”

She had a “ton” of ideas in theoretical physics and needed to be strategic about how she spent her time. As a manager, she also needs to be strategic about the programs she supports to ensure they are advancing.

In addition to creating a respectful and safe workplace, Hewett would like to delve into the beautification of the campus.

“I want to involve the staff” in that effort, she said.

Hewett served as a mentor from 2008 to 2011 for Rouven Essig when he was a postdoctoral researcher at SLAC.

In an email, Essig, who is now Professor of Physics at the C.N. Yang Institute for Theoretical Physics, described her as “an exceptional leader” who is “friendly and approachable” with a “clear vision.”

Essig lauded Hewett’s vision for recognizing the value of funding small-scale experiments in particle physics, which are low-cost but can enable “major discoveries,” he added. “I think this approach is having a big impact in particle physics research in the U.S. and elsewhere.”

Essig is “excited to see how she will further strengthen BNL and the connections to Stony Brook.”

Hewett has had “numerous important contributions to our understanding of physics beyond the Standard Model and how it can be discovered with experiments,” Essig added.

In her career, Hewett found it “terrifically exciting to discover something” in which she was the “only person in the world for that instant of time that knows something,” she said.

For her, that moment occurred when she was developing work on a particular theory of extra spacetime dimensions.

Collider appeal

Hewett came to BNL in part because of the ongoing construction of the Electron Ion Collider, which will study quarks and gluons in the nucleus and the strongest forces in nature.

“I did a lot of studies of potential future colliders,” said Hewett. “I’m excited to be at a lab where a collider will be built.”

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The combat boots and dog tags worn by Alan Alda in M*A*S*H will be auctioned off on on July 28. (LM Otero/AP)

Update:

The combat boots and dog tags Alan Alda wore while playing Hawkeye Pierce on the  television series “M-A-S-H” sold at auction on July 28 for $125,000.

Alda held onto the boots and dog tags for more than 40 years after the show ended but decided to sell them through Heritage Auctions in Dallas to raise money for the Alan Alda Center for Communicating Science at Stony Brook University.

The buyer’s name wasn’t released.

——————————-

When Alan Alda reported to the 4077th Mobile Army Surgical Hospital in the summer of 1972, he received two items from wardrobe that became the only M*A*S*H mementos he kept when the show ended in 1983.

Costumers handed him a pair of scuffed-up combat boots, inside which someone had written in black marker the name of his character: “HAWKEYE.” He was also given a pair of dog tags which the names of strangers had been stamped: Hersie Davenport and Morriss D. Levine.

Alda was grateful the dog tags didn’t say Benjamin Franklin Pierce of Crabapple Cove, Maine. That would have made them mere props that couldn’t have carried the weight of war. Wearing those real dog tags, the genuine article, “seemed like a handshake,” Alda says. Until recently, he knew nothing about the two men whose names are on those dog tags — one, a Black soldier from the South; the other, a Jewish man from New York.

“Yet every day for 11 years, putting them on over my head and wearing them, I had a very close connection with them,” said Alda. “I always wondered what their lives were like. Were they alive, or were they dead? How had they served? They were real people to me, even though I didn’t know anything about them other than their names. But to this day, I remember the names very well, and that’s why it meant a lot to me.”

These pieces of wardrobe, the last remnants of his tour of duty, mean so much to Alda he now parts with the boots and dog tags only to help fund what has become one of his greatest passions. 

Heritage Auctions will auction off Alda’s M*A*S*H mementos in a single-lot auction on July 28. All the money raised will benefit the Alan Alda Center for Communicating Science at Stony Brook University and the university’s School of Communication and Journalism. Heritage will also donate all of its proceeds to the center.

“Hawkeye’s boots and dog tags are not only entertainment memorabilia from a beloved series, but the cherished keepsakes of a national treasure,” says Heritage’s Chief Strategy Officer Joshua Benesh. “And before that, they were the personal artifacts of real soldiers. They now take on a new life as a source of fundraising for a noble cause in which a noble man has invested so much of his time and resources, and we are honored to be even a small part of such a grand gesture.”

Alda kept the boots and dog tags for years in a closet because he did not know where else to store them.

“Then I realized that they could come to life again to be used to help the Center for Communicating Science because, probably, somebody would be interested in having a memento of the show,” he says. “I can’t think of a better use for them.”

When asked if it will be difficult to say goodbye to these last keepsakes from M*A*S*H he responded, “Not at all. Because I knew they were going to a good cause. They were going to do more good than sitting in my closet. They were screaming, ‘Let me out!’ I thought, what a great chance to put these boots and dog tags to work again. For 11 years, they helped promote the idea that human connection could be a palliative for war. And now they can promote the idea that a human connection can get us to understand the things that affect our lives so deeply.”

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Maurizio Del Poeta. File photo from SBU

By Daniel Dunaief

Maurizio Del Poeta is taking another approach to battling fungal infections that can be deadly, particularly for people who are immunocompromised.

Maurizio Del Poeta. Photo from SBU

A Distinguished Professor at Stony Brook University in the Department of Microbiology and Immunology at the Renaissance School of Medicine at Stony Brook University, Del Poeta has made progress in animal models of various fungal infections in working on treatments and vaccines.

After receiving an additional $3.8 million from the National Institutes of Health for five years, Del Poeta is expanding on some findings that may lead to a greater understanding of the mechanism that makes some fungal infections problematic.

The Stony Brook Distinguished Professor is studying “what makes people susceptible to fungal infections,” he said. “It’s something I’m really passionate about.”

Del Poeta explained that researchers and medical professionals often focus on the people who get sick. Understanding those people who are not developing an infection or battling against a fungus can provide insights into ways to understand what makes one population vulnerable or susceptible and another more resistant.

Expanding such an approach outside the realm of fungal infections could also provide key insights for a range of infections in the future.

Indeed, the awareness of specific signals for other infections could help protect specific populations, beyond those who had general categories like underlying medical conditions, who might be more vulnerable amid any kind of outbreak.

“It’s possible that the study we are doing now with fungi could stimulate interest” in other areas of infectious disease, Del Poeta said.

He suggested that this was “pioneering work” in terms of fungal infections. At this point, his lab has produced “strong preliminary data.”

An important drug treatment side effect as a signal

This investigation arises out of work Del Poeta had done to understand why some people with multiple sclerosis who took a specific drug, called fingolimid, developed fungal infections during their drug treatment.

Del Poeta observed that the drug inhibits a type of immunity that involves the movement of lymphocytes from organs into the bloodstream.

Fingolimid mimics a natural lipid, called a sphingolipid. Del Poeta showed that this sphingolipid is important to contain the fungus Cryptococcus neoformans in the lung. When its level decreases, the fungus can move from the lung to the brain.

Indeed, Fingolimid mimics sphingosin-1-phosphate (S1P) and binds to several S1P receptors.

Del Poeta believes that the pathway between S1P and its receptor regulates the immunity against Cryptococcus. Blocking a specific receptor is detrimental for the host and may lead to reactivation of the fungus.

Putting a team together

Nathália Fidelis Vieira de Sá. Photo by Futura Convites studio

Del Poeta has been working with Iwao Ojima, a Distinguished Professor and the Director of the Institute of Chemical Biology and Drug Discovery in the Department of Chemistry at Stony Brook, to create compounds that energize, instead of block, the target of fingolimid.

Del Poeta has recruited two scientists to join his lab in this effort, each of whom has educational experience in nursing.

Nathália Fidelis Vieira de Sá, who is a registered nurse at the Federal University of Minas Gerais and a chemistry technician at Funec- Contagem City, will join the lab as a technician in the second week of September.

Fidelis Vieira de Sá, who currently lives in her native Brazil, is an “expert on collecting and analyzing organs for mice,” explained Del Poeta in an email.

For her part, Fidelis Vieira de Sá is thrilled to join Del Poeta’s lab at Stony Brook. “I’m very excited,” she said in an email. She is eager to get started because the research is “of such great relevance to public health” and is occurring at such a “renowned institution.”

Fidelis Vieira de Sá believes this is a public health issue that could have a positive impact on people with immunodeficiency conditions who need effective treatment so they live a better, longer life. When she was a peritoneal dialysis nurse, she had a few patients who had fungal infections.

“This is very serious and challenging, detection is difficult, and the life expectancy of these patients drops dramatically with each episode of infection,” she explained. 

Fidelis Vieira de Sá, who has never lived outside Brazil, is eager for new experiences, including visiting Central Park, the Statue of Liberty, Times Square, and the One World Trade Center Memorial.

As for the work, she hopes that, in the near future, Del Poeta will “be able to explain this mechanism deeply and to develop new drugs that will act on this receptor.”

Dr. Marinaldo Pacífico Cavalcanti Neto

Dr. Marinaldo Pacífico Cavalcanti Neto, who is an Assistant Professor at Federal University of Rio de Janeiro, will be arriving at Stony Brook University on August 6. Dr. Neto earned his bachelor of science in nursing and has a PhD in biochemistry from the Medical School of Ribeirão Preto at the University of São Paulo.

Del Poeta described Dr. Neto as an “expert on animal handling and genotyping,”

Dr. Neto recognizes the burden of fungal infections around the world and hoped to work with someone with Del Poeta’s credentials and experience in immunology and infection.

Understanding how cells eliminate infection, how cells might have a lower capacity to control an infection, and looking for how cells respond to treatments such as fingolimid could be a “great strategy to understand why these are so susceptible,” he said.

While Dr. Neto’s background is in immunology, he hopes to learn more about molecular biology.

Unlike Fidelis Vieira de Sá, Dr. Neto, who will live in Centereach, has worked previously in the United States. He has experience at the National Institutes of Health and at the University of California at San Diego and has been attending Del Poeta’s lab meetings from a distance for about a month.

Dr. Neto, whose interest in science increased while he watched the TV show Beakman’s World while he was growing up, is eager to work in an area where he can apply his research.

He appreciates that his work may one day “be used in the generation of protocols in a clinic.

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The tour and demonstrations at Canon Americas headquarters provided insight into AMLOS and Kokomo software as well as education regarding the industry. Photo courtesy of Canon U.S.A.
The tour and demonstrations at Canon Americas headquarters provided insight into AMLOS and Kokomo software as well as education regarding the industry. Photo courtesy of Canon U.S.A.
The tour and demonstrations at Canon Americas headquarters provided insight into AMLOS and Kokomo software as well as education regarding the industry. Photo courtesy of Canon U.S.A.

In a continued effort to support higher education and make an impact on the local community, Canon U.S.A., Inc., a leader in digital imaging solutions, hosted students from Stony Brook University on  July 19 at its Canon Americas headquarters in Melville.

The group of 35 international students, who are enrolled in a master of science in technology management (MSTM) program, were provided a tour of the showroom. A demonstration followed for AMLOS (Activate My Line of Sight), a software-and-camera product suite designed to provide a new level of engagement for collaboration across multiple locations using the power of Canon’s image processing technology, along with hand gesture controls. 

Students also saw the Kokomo software — Canon’s first application for a virtual reality (VR) platform1 that enables face-to-face communication in a virtual space with live-action video using easy-to-use equipment — with a presentation that closed the live event. 

Canon’s guest speakers also provided information about Canon U.S.A., Inc.’s contribution to the industry and addressed questions from students. 

“The presentation was outstanding and the students were impressed at how the Canon representatives were able to take complex situations and technology and explain it in a straight-forward and clear manner,” said Robert Ettl, a Stony Brook professor of marketing who attended the event. “It was amazing to see all the developments in the consumer and industrial markets and our students learned a lot from our trip to Canon.” 

As part of their degree requirements, students earn six of the 36 total credits required at the New York Residence Program at Stony Brook University during their three weeks visiting the Empire State from South Korea. The program is in its 22nd year. 

The collaboration between Canon and Stony Brook continues a strong connection that includes Canon’s annual sponsorship of the Japan Center Essay Competition Awards Ceremony, which honors students for work that demonstrates their awareness and understanding of the Japanese culture. 

“We were delighted to host the students from Stony Brook University and provide information about our industry and Canon’s exciting initiatives,” said Lisa Chung,  director, talent acquisition, university relations and diversity and inclusion at Canon U.S.A., Inc.

“Teaching about our proud history with a tour of our showroom – and providing live demonstrations of AMLOS and Kokomo — helped reinforce our commitment to higher education, collaborative solutions and virtual reality and hopefully provided strong insights into the industry for those interested in developing their professional skills,” she said. 

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