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Daniel Dunaief

From left, Darren Martin and Benjamin Hsiao during a visit to Ram’s Head Inn on Shelter Island. Photo from Darren Martin

By Daniel Dunaief

One person’s garbage is another’s treasure.

Benjamin Hsiao

Benjamin Hsiao has plans to convert garbage — from dog poop to food waste and even cardboard boxes — into the kind of low cost materials and fertilizers that can help combat climate change. His primary target is agricultural residues because of their volume and collectability.  

A Distinguished Professor of Chemistry at Stony Brook University, Hsiao and collaborator Darren Martin at the University of Queensland in Australia recently were awarded one of 16 multidisciplinary grants totaling $11.4 million from the National Science Foundation’s Convergence Accelerator program.

Hsiao, who is the primary investigator, will receive $570,000 over the next nine months in Phase I of the research effort while Martin will collect $180,000 from the Commonwealth Scientific and Industrial Research Organisation in Australia.

The researchers plan to take a zero waste approach to create a circular system that will generate efficiencies, reduce pollution and combat climate change.

The research is focused on creating immediate solutions for current problems, Hsiao said.

The NSF received “many quality submissions” and chose the winners after a rigorous review process, the NSF said.

The proposal from Hsiao and Martin stood out as it is “based on strong science” and make a clear connection to climate change,” NSF officials said.

Hsiao and Martin were delighted with the award and the opportunity not only to make contributions through their own research, but also to work with some of the other recipients.

“I am so pleased on many counts,” Martin explained in an email from Australia. First, Martin and Hsiao, who met at a conference in 2014, followed through on long standing plans to work together. Second, this program, which the NSF started in 2019, is about “early engagement with the market to get feedback on new technologies and platforms.”

Martin suggested it was akin to a “business model boot camp” that includes support and opportunities to pressure test ideas early. “This approach could really accelerate and compress the number of years traditionally taken to see helpful new technologies out in society sooner.”

If they are successful and effective, the scientists can apply for competitive Phase II funding within the year, which includes $5 million for two years and which four or five of the Phase I recipients, who are from a host of A-list research institutions, will receive.

Solids and liquids

Hsiao has been working with solid plant-based waste to create filters that can purify water at a low cost since 2009.

“Nanoscale cellulose materials can be used for water purification,” said Hsiao.

The needles of plants, from shrubs to bushes to feedstock, all have the same cellulosic nanostructure. Hsiao’s technology can convert these different feedstock into similar carboxy-cellulose nanofibers that can be used as purifying agents with negative charge. These filters can remove oppositely charged impurities.

Additionally, Hsiao plans to use solid plant based biomass to create a biogel. Rich in nutrients, the biogel is like the naturally occurring residue that is at the bottom of streams, which is a nutrient-rich mix of dead trees and grass.

The biogel, which is also funded by the NSF, has three applications. First, it can replace soil to grow food or for seed germination, which could be useful to grow food in space. It can also reduce the impact of drought.

Second, it can make a farm more resistant to drought because the material in biogel retains water for a longer period of time and amid drier conditions.

Third, the biogel can induce vegetation or plant growth in drier or sandier areas. Such growth, which could occur along the shoreline of Long Island, could help reduce erosion, Hsiao said. The biogel can also reduce desertification.

Martin explained that Stony Brook University and the University of Queensland have two different biogel platforms that they may hybridize.

Hsiao’s team is “very strong in the chemistry and physical chemistry side,” Martin wrote. “Being based in a Chemical Engineering School, we have been pretty good over the years at finding the most efficient, cost-effective ways to manufacture bio-based materials and composites at scale.”

Fertilizer

Building and expanding on this work, Hsiao is focusing on the liquid waste from biomass as well.

“With the new thinking, we have a circular design,” he said.

Using a nitric acid treatment that is similar to composting and that removes human pathogens, liquid biomass can become an effective fertilizer, which sanitizes animal and human waste.

Nitric acid also releases the existing nutrients in feedstock, which provides more nitrogen and phosphorous to help plants grow.

The ideal treatment would involve providing a controlled amount of fertilizer each day, Hsiao explained.

Farmers, however, can’t put that kind of time and resources into spraying their fields. Instead, they spray a fertilizer that becomes run off when it rains. Artificial intelligence and robots can deploy fertilizer in a more cost effective manner.

The nitrogen from the run off winds up in streams and other water bodies, where it can cause a process called eutrophication, leading to the kind of algal blooms that rob oxygen of water, making it more difficult for desirable marine life to survive and close beaches to swimming.

By using an efficient process for producing fertilizer that includes taking the inedible parts of plants, and making them a part of the circular process, run off could decrease by “half or even more,” Hsiao said.

Martin added that he and Hsiao have, in the back of their minds, a plan to create scalable fertilizer for single family farms in developed and developing nations.

“Our modeling may indeed show that ‘distributed manufacturing’ of the biogels from agricultural residues using a ‘mobile factory placed on the farm’ may be the smartest way to get there,” Martin explained. “This is exactly the sort of question the Convergence Accelerator is designed to test.”

Martin said that he hopes this technology lead to an array of jobs that support farming under a variety of circumstances.

Sorghum, which is one of his favorite crops, is ultra resilient and is of increasing global importance. Its ability to withstand environmental stress and thrive on low input marginal farmland make it the ‘golden crop of the future,’ Martin added.

This crop makes it an “attractive option to transform infertile land into profitable agrivoltaic farms supplying raw materials for emerging non-foo markets such as these biogels,” Martin wrote.

Pixabay photo

By Daniel Dunaief

Daniel Dunaief

When our children were young, a friend recently told me, she viewed the parents of people she met through a binary process.

A mom of two boys, she figured she had a better chance, at least in the first 10 years or so of her sons’ lives, of interacting with the parents of other boys. When she met girls and their families, she was polite and friendly, without putting too much effort into getting to know them.

Fast forward almost two decades, and her children, like mine, are out of the house. She and her husband have an adorable small dog that they dote on, transferring their abundant parenting attention to a canine companion.

Nowadays, my friend said, she sees people through a similar lens. She takes her small dog to a dog park, where a fence separates pets under 40 pounds from the bigger, heavier versions. When she meets someone outside the park with a dog, she’s more likely to pay attention to their names and their stories if they have a small dog.

As I considered what she said about the parents of boys and girls, as well as the owners of dogs of different sizes, I wondered about the metaphorical fences we create.

Sure, those fences make it easier for us to find people who have similar interests and opinions and who might not challenge us or disagree with us in our decision-making. Those fences also, however, separate us from others with whom we might have even more connections or common interests than we thought, especially if the filter for our “in” and “out” groups is as arbitrary as having sons, daughters or small dogs.

What if a man with a large dog worked in a similar field, had two children about my friend’s offspring’s ages, and went to the same college at the same time? Then again, what if a woman on the other side of the fence had nothing in common with my friend? She had no children, grew up in another country, worked in a completely different field, and didn’t see any of the same movies or read the same books? Would that make her less or more interesting? Perhaps that woman might be fascinating for her life experiences, compelling for her opinions, and amazing in her own way.

Recently, I sat in the window seat of a plane next to a large man who was stuck in the middle. An army veteran, he laughed as we reached our destination, saying he was unaccustomed to landing in planes. I took the bait, asking him why. He said he’d made over 150 jumps out of airplanes. 

He and his unit jumped out of planes at 800 feet, although he didn’t need to do much jumping, as he felt as if a hand pulled him out when he got to the opening. He never had to pull a chord, as the parachute automatically started opening within a second of leaving the plane.

On one type of plane, he stepped out and immediately started falling. Another had a small “bubble” outside the entrance, where he and others stood before leaving the plane. One of his army unit once forgot about the platform, took a small hop on the landing, and then rolled along the entire side of the plane. The others heard as his body scraped the airplane all the way to the back. Fortunately, the impact didn’t cause severe injuries.

One of the many instructions he received was to keep his chin on his chest as he exited. On his first jump, he didn’t, which caused enough discomfort that he never made that mistake again. He reached the ground at 38 miles per hour, at which point he was supposed to tuck and roll, ending on his back. Once, a crosswind turned him upside down and he landed on his head, cracking his helmet and causing a concussion.

Listening to his stories, I learned about something I will likely never do and connected with someone I will likely never see again. He did, however, expand my horizons and share his compelling life experiences, among other stories. I appreciated the opportunity to connect with someone who lives outside whatever fences I intentionally or unintentionally put up around me.

Photo by David Ackerman

By Leah S. Dunaief

Leah Dunaief

Maybe it sounds like I’m tooting our horn too much, but I have to say how proud I am of the columnists who write for our papers and website. They are clearly bright and offer the reader information and knowledge that aren’t usually found even in a big metro daily or a glossy magazine. They are, collectively and individually, one of the main reasons our hometown newspapers have managed to survive while so many of our colleagues, 25% of them in the nation, have had to shut their doors.

Readers want to learn from our regular columnists, who, by the way, are local residents. That’s not surprising, though, because the population we serve is exceptional, accomplished in their own right, and can be expected to harbor such talent. Let me explain.

The columnists are found in the second section of the newspaper, called Arts & Lifestyles. In the interest of full disclosure and without false modesty, I point out and salute my youngest son, Dr. David Dunaief. He is a physician totally committed to helping his patients, and the high regard is returned by them in equal measure, as testimonials about him confirm. In addition, he writes every week about current medical problems and brings readers up to date with the latest research and thinking regarding common ailments. I know him to be a voracious reader of medical journals and he footnotes his sources of expertise at the end of every “Medical Compass” column. 

Dr. Matthew Kearns is a longtime popular veterinarian who writes “Ask the Vet,” keeping our beloved pets healthy. Michael E. Russell is a successful, retired financial professional who cannot cut the cord with Wall Street, and  shares his thoughts on the economy and suggesting current buys on the stock market. He will also throw in something irreverent, or even askance, to keep you tuned in. 

Also writing knowledgeably on the contemporary scene about finance and the economy is Michael Christodoulou, who is also an active financial advisor. Ever try to read your auto insurance policies? If I had trouble falling asleep, they would knock me out by the second paragraph. Enter A. Craig Purcell, a partner in a long-established local law firm, who is attempting to explain auto insurance coverage, a merciful endeavor, with his column. His words do not put me to sleep. Shannon Malone will alternate the writing for us. Michael Ardolino, a well-known realtor, somehow manages to make both ends of a real estate transaction, for buyers and sellers, sound promising at this time. 

Our lead movie and book reviewer is the highly talented Jeffrey Sanzel. In addition to being a terrific actor, he is a gifted writer and almost always feels the same way about what he is reviewing as I do. No wonder I think he is brilliant.  Father Frank has been writing for the papers for many years and always with great integrity and compassion. 

John Turner, famous naturalist and noted author and lecturer, keeps us apprised of challenges to nature. This is a niche for all residents near the shorelines of Long Island. He also writes “Living Lightly,” about being a responsible earth dweller. Bob Lipinski is the wine connoisseur who travels the world and keeps us aware of best wines and cheeses.

Lisa Scott and Nancy Marr of the Suffolk County League of Women Voters, keep us informed about upcoming elections, new laws and important propositions. Elder law attorney Nancy Burner tells us about Medicare, estate planning, wills gifting, trustees, trusts and other critical issues as we age.

The last columnist I will mention is Daniel Dunaief, who, like bookends for my salute, is also my son. Among several other articles, he writes “The Power of Three,” explaining some of the research that is performed at Stony Brook University, Brookhaven National Labs and Cold Spring Harbor Laboratory. He makes a deep dive into the science in such a way that layman readers can understand what is happening in the labs. He has been paid the ultimate compliment by the scientists for a journalist: they pick up the phone and willingly talk to him, unafraid that he will get the story wrong or misquote them. In fact, he has been told a rewarding number of times by the researchers that his questions for the articles have helped them further direct their work.

When my sons began writing for TBR News Media, a few readers accused me of nepotism. I haven’t heard that charge now in years.

P.S. Of course, we can’t forget Beverly C. Tyler and Kenneth Brady, stellar historians both.

Kaushik Mitra. Photo from SBU

By Daniel Dunaief

From over 66 million miles away, they take pieces of a puzzle and try to fill in the picture. In addition to looking at what’s there now, they also use clues to look back in time.

For the last eight years, researchers suspected that the presence of manganese oxide suggested that Mars had atmospheric oxygen billions of years ago. That’s because, on Earth and in water, oxygen converts manganese to manganese oxide.

Such a process whets the appetite in the search for prehistoric life on Mars that, like so many creatures on Earth, breathed oxygen.

The Martian story, however, involves puzzle pieces that came together in a different way.

In a paper published last month in Nature Geosciences, Kaushik Mitra, a postdoctoral researcher at Stony Brook University in the Department of Geosciences, suggested through geochemical modeling that oxygen on Mars, even if it was abundant billions of years ago, wouldn’t have created manganese oxide.

That’s because the water on Mars was acidic, with a pH of less than 5.5, which is below the neutral 7 level. Under those conditions, oxygen wouldn’t oxidize manganese.

Using experiments, Mitra showed that the manganese oxide could form in acidic water in other ways.

“Mars and Earth fluid conditions are very different,” Mitra said. “What I showed in my experiments is that oxygen in acidic fluids will not be able to oxidize manganese.”

Mitra conducted research that were part of his PhD work in Jeffrey Catalano’s lab at Washington University in St. Louis, MO. 

Taking oxygen out of the picture, Mitra also detailed previous efforts that might explain the presence of manganese oxide, such as ultraviolet light. The manganese oxides formed in sub surface fractures, which this light couldn’t reach.

So, what happened?

“If the originally proposed (and plausible) oxidants were not the cause, there had to be some culprit,” Mitra explained in an email. “So there had to be some other oxidant.”

Bromine and chlorine

Enter chlorine and bromine, which are both halogens, or reactive non-metallic elements.

No one had looked into the potential of oxyhalogen compounds to produce manganese oxides in Mars-like conditions.

Bromate, which is a bromine atom attached to three oxygen atoms, can oxidize manganese in orders of magnitude faster than other oxidants, particularly in acidic conditions. Chlorate, which is also a chlorine atom attached to three oxygen atoms, alone can’t do it, but, with a small quantity of bromate, can create quantities of manganese oxide.

The oxygen attached to chlorine and bromine can come from water or any other ingredient, and doesn’t need oxygen gas to form.

“People didn’t really appreciate until [Mitra’s] paper came along that [manganese] is highly reactive towards these oxyhalogen compounds that he has been working with, so it gives us a whole new way to think about how [manganese-oxides] might form on Mars,” Joel Hurowitz, Associate Professor in Geosciences at Stony Brook University, explained in an email. Mitra has been working as a postdoctoral researcher in Hurowitz’s lab since November of 2021.

While oxygen may not have caused the change in manganese, the search for Martian life doesn’t end here. Some organisms, including on Earth, don’t need oxygen to survive.

Extremophiles, which can survive in the Great Salt Lake, the Dead Sea, and around hydrothermal vents at the bottom of the ocean, do not need oxygen.

Mitra’s research “teaches us to be cautious in our astrobiology strategy and consider all the alternative possibilities,” Hurowitz explained. “It is entirely possible that Martian life did not depend on [oxygen] or produce [oxygen] as a by-product of its metabolism.”

For the first two billion years of life on Earth, high concentrations of oxygen would have been toxic to microbial life, Hurowitz added.

To be sure, just because halogens like chlorine and bromine can explain the presence of manganese oxide instead of oxygen doesn’t rule out the possibility that Mars had oxygen.

Paradigm shift

Mitra has continued his exploration of the importance of oxyhalogen species in Hurowitz’s lab to improve the understanding of how they interact with various mineral phases that are considered key records of paleoenvironmental conditions on Mars.

On a more immediate scale, Mitra’s approach to his work has created something of a paradigm shift in Hurowtiz’s lab. When the postdoctoral researcher arrived at Stony Brook, he immediately started between 30 and 40 separate experiments within the span of a month. 

This effort contrasts with the attempt to create one perfect, completely controlled experiment that can take months of time that might be lost if something went wrong.

“It has actually changed the way that I think about experimental project methods,” Hurowitz wrote. “It’s a great new way to explore geochemistry and my students are adopting many of the approaches he’s brought into the lab.”

Hurowitz described Mitra as a “great addition” to the group.

A passion for science

A native of Bhagalpur, India, which is in the state of Bihar, Mitra had a strong interest in chemistry during his youth.

He attended the Indian Institute of Technology Kharagpur, where he earned an integrated Bachelors and Masters of Science Degree in Applied Geology.

Mitra, who currently lives in Centereach, is fluent in English, Hindi and Bengali and is learning Nepali, the native language of his spouse Priyanka Sharma who is from Nepal.

Sharma, who is an Indian Nepali, is applying for graduate school in English Literature and Comparative Literature.

An avid reader whose favorite genre is philosophy, Mitra is currently reading Fyodor Dostoesky and Friedrich Nietzsche.

A long distance runner, Mitra ran a 10K in Queens last year and would like to run a half marathon in the spring.

He will likely finish his postdoctoral research by next year, at the latest, at which point he will apply for a faculty job.

Passionate about teaching, Mitra has been a committed mentor to other students at Stony Brook, Hurowitz said.

Mitra created a YouTube channel for geology and geochemistry undergraduates and graduates in which he shares lessons about geoscience and chemistry in English and Hindi, which is available at https://www.youtube.com/@kmicalmindset6322.

“I am trying to inspire more people to come into planetary geoscience,” he said, especially undergraduates.

Pixabay photos

By Daniel Dunaief

Daniel Dunaief

Even as we study evolution, we ourselves evolve over time. No, we don’t learn to fly or to breathe underwater. We change over the decades, in part because of social pressure and in part because, well, our cells, organs and experiences align to make us different decadal versions of ourselves. With that in mind, I’d like to share some snapshots from my life.

First decade:

Likes: I adored my parents (most of the time). I also appreciated the opportunity to make new friends and to play any game that involved chasing a ball.

Dislikes: long distances running, homework, dark nights, losing electricity, sitting in the middle of a station wagon with my legs cramped under me. 

Favorite food: pizza and grilled cheese with ketchup. It’s not for everyone, but I loved it.

Favorite sport to play: basketball.

Favorite sport to watch: baseball.

Biggest worry: finding parents.

Second decade:

Likes: time with friends, the freedom to drive somewhere on my own (later in the decade, of course).

Dislikes: tough teachers eager to teach me too many lessons, rejections from friends, and too many questions from parents. Waiting for parents to pick me up (until I could drive). Developing an intolerance to dairy, which removed pizza, ice cream and mac and cheese from food options.

Favorite food: Good Steer burger supremes with a root beer and ballpark hot dogs.

Favorite sport to play: baseball

Favorite sport to watch: baseball.

Biggest worry: Losing parents. Getting into college.

Third decade

Likes: getting a job where someone not only paid me to do something I wasn’t sure I was qualified to do, but also sent me on planes to do it. Spending time with friends. Going on vacations with friends and family.

Dislikes: working on weekends and holidays. Going on horrible dates with people who were a little too eager to see fights where teeth got knocked out during hockey games. Then again, some of those unsuccessful dates still bring a smile to my face.

Favorite food: Thai food at a restaurant on the Upper East Side.

Favorite sport to play: volleyball.

Favorite sport to watch: baseball.

Biggest worry: Finding enough time to exercise.

Fourth decade:

Likes: enjoying the miraculous connection that comes from meeting girlfriend/wife. Listening to my wife laugh and seeing her smile. Holding my son and daughter and feeling them relax enough to go to sleep.

Dislikes: trying to figure out how to handle when children got sick, needing something we didn’t have, and packing enough stuff in the diaper bag and the car for needy children.

Favorite food: Who tastes food at this point? We inhaled it in between picking up the food the kids spilled on the floor or in the car.

Favorite sport to play: softball in Central Park.

Favorite sport to watch: my daughter’s active and exciting volleyball matches and my son’s soccer games. I knew nothing about soccer, so I could just be a supportive father and fan without offering unwelcome and unhelpful advice.

Biggest worry: How to keep kids healthy.

Fifth decade:

Likes: holidays, vacations and not needing to stand over the kids when they got too close to the water. Hooray for independent swimming.

Dislikes: driving everywhere with kids and their friends who made the car stink so badly at times that I opened windows in freezing temperatures. Watching kids disappear into their cell phones.

Favorite food: fresh fish on vacations.

Favorite sport to play: I barely played anything. I coached kids and bobbed and weaved between the entitled requests from parents.

Favorite sport to watch: daughter’s volleyball and son’s baseball.

Biggest worry: helping steer kids in the right direction.

Sixth decade:

Likes: time with family and friends, days when pain in my hip stays the same or, rarely, is less than the day before.

Dislikes: not knowing how to handle important technology, an awareness that I’m older than my friend’s parents were when I was growing up, and I thought they were old.

Favorite food: anything that doesn’t keep me up at night.

Favorite sport to play: baseball or anything that doesn’t cause pain the next day.

Favorite sport to watch: baseball.

Biggest worry: the speed at which each day, month and year passes. The prevalence of anger for its own sake and the health of the planet our children are inheriting.

Nandita Kumari at the 53rd Lunar and Planetary Science Conference in Woodlands, Texas in March of 2022. Photo by Delia Enriquez Draper from the Lunar and Planetary Institute

By Daniel Dunaief

Some day in the not too distant future, an astronaut may approach rocks on the moon and, with a handheld instrument, determine within minutes whether the rock might have value as a natural resource or as a source of historical information.

That’s the vision Nandita Kumari, a fourth-year graduate student in the Department of Geosciences in the College of Arts and Sciences at Stony Brook University, has.

In the meantime, Kumari was part of a multi-institutional team that recommended two landing sites in the moon’s south polar region for future Artemis missions. 

Nandita Kumari at a San Francisco Volcanic Field, where she was doing stress and strain measurements of cinders. Photo by Saurabh Subham.

The group, which included students from the University of Arizona, the University of California Los Angeles, and the University of Buffalo, used several criteria to recommend these two sites.

They looked at the resources that might be available, such as water and rocks, at how long the areas are in sunlight and at how the features of the land, from the slope of hills to the size of boulders, affects the sites accessibility.

“These two sites ended up fulfilling all these criteria,” Kumari said. Models suggest water might be present and the regions are in sunlight more than 80 percent of the time, which is critical for solar-powered devices.

The group used high-resolution data from the Lunar Reconnaissance Orbiter to create a map of all the rocks and to model the geological diversity of the site. They used infrared images to gather data from areas when they were dark. They also added temperature readings.

To the delight of the team, NASA selected both of the sites as part of a total of 13 potential landing locations.

Planetary scientist David Kring advised the group during the process. Kring has trained astronauts and worked on samples brought back from the Apollo missions.

At the end of the first year of her PhD, Kumari received encouragement to apply for the virtual internship with Kring from Stony Brook Geosciences Professor Tim Glotch, who runs the lab where she has conducted her PhD work.

Putting a number on it

Kumari said her thesis is about using machine learning to understand the composition of resources on the moon. She would like to use artificial intelligence to delve deeply into the wealth of data moon missions and observations have been collecting to use local geology as a future resource.

“Instead of saying something has a ‘little’ or a ‘lot’” of a particular type of rock that might have specific properties, she would like to put a specific numerical value on it.

An engineer by training, Kumari said she is a “very big fan of crunching numbers.”

Since joining the lab, Kumari has become “our go-to source for any type of statistical analysis me or one of my other students might want to conduct,” Glotch explained.

The work Kumari has done provides “large improvements over traditional spectroscopic analysis techniques,” Glotch added.

In examining rocks for silicic properties, meaning those that contain silicon, most scientists describe a rock as being less or more silicic, Kumari said.

“It’s difficult to know whether 60 percent is high or 90 percent is high,” she added. Such a range can make an important difference, and provides information about history, formation and thermal state of the planet and about potential resources.

With machine learning that trains on data collected in the lab, the model is deployed on orbiter data.

The machine learning doesn’t stop with silica. It can also be extended to search for helium 3 and other atoms.

Understanding and using the available natural resources reduces the need to send similar raw materials to the moon from Earth.

“There has to be a point where we stop” transporting materials to the moon, said Kumari. “It’s high time we use modern practices and methods so we can go through really large chunks of data with limited error.”

The machine learning starts with a set of inputs and outputs, along with an algorithm to explain the connection. As it sorts through data, it compares the outputs against what it expects. When the data doesn’t match the algorithm, it adjusts the algorithm and compares that to additional data, refining and improving the model’s accuracy.

A love for puzzles

Kumari, who grew up in Biharsharif, India, a small town in the northern state of Bihar, said this work appeals to her because she “loves puzzles that are difficult to solve.” She also tries to find solutions in the “fastest way possible.”

Kumari was recently part of a field exploration team in Utah that was processing data. The team brought back data and manually compared the measurements to the library to see what rocks they had.

She wrote an algorithm that provided the top five matches to the spectroscopic measurements the researchers found. Her work suggested the presence of minerals the field team didn’t anticipate. What’s more, the machine provided the analysis in five minutes.

The same kind of analysis can be used on site to study lunar rocks.

“When astronauts go to the moon, we shouldn’t require geology experts to be there to find the best rocks” she said. While having a geologist is the best-case scenario, that is not always possible. “Anyone with a code in their instruments should be able to decide whether it is what they’re looking for.”

As for her interest in space travel, Kumari isn’t interested in trekking to the moon or Mars.

While she believes the moon and Mars should be a base for scientific experiments, she doesn’t think people should focus on colonizing either place.

Such colonization ideas may reduce the importance of working on the challenges humans have created on Earth, including climate change.

“You can’t move to Mars,” Kumari said. The litmus test for that occurred during Covid, when people had to isolate.

“If we couldn’t stay in our homes with all the comfort and everything, I do not see a future where this would be possible with stringent constraints on Mars,” she added.

An advocate for women in STEM fields, Kumari said women should pursue scientific careers even if someone else focuses on their mistakes or tries to break their confidence.

“The only way to stop this from happening is to have women in higher places,” she explained. “We should also be supportive of each other and grow together.”

Photo from Wikimedia Commons

By Daniel Dunaief

Daniel Dunaief

I heard from a friend, who heard from another friend whose neighbor’s cousin is the babysitter of someone who works in Congress. So, it has to be true.

Here’s the deal: I know some of the concessions Kevin McCarthy (R-CA) made to become speaker of the house.

The person who heard it fourth hand was in the bathroom, minding his own business, trying, from what I understand, to make his best guesses at Wordle on his phone while battling an upset stomach when three of the principal negotiators in the process entered the bathroom and spoke in whispers.

The first concession is that McCarthy must begin each day by saying the words “we are all equal, but some are more equal than others,” at which point he’s supposed to subtly make the letters G and O in sign language with his hands to show that he’s thinking about “Animal Farm” author George Orwell.

Then, he has to look at the audience carefully to see if Rep. Matt Gaetz (R-FL) has had a bad night. If Gaetz gives him a particular signal, he’s not allowed to bang his gavel too loudly, to prevent a headache from getting worse.

Once he’s gotten everyone’s attention, he then agreed that he’ll lead the house in the Pledge of Allegiance, pausing when he reached the “under God” section to make it clear that religion is not only okay, but that many people, particularly those who might not have otherwise voted for him, believe in God.

When President Joe Biden (D) gives his state of the union address, he will give at least 15 head shakes, five winces and nine arched eyebrows. At the end of the speech, to defend former president Donald Trump (R), he plans to take a page out of the previous speaker’s playbook by picking up the copy of Biden’s speech and tearing it up in disgust as it were the first chapter of a book he’d like to ban from libraries around the country.

Speaking of beyond belief, McCarthy has then agreed that if Rep. George Santos (R-NY), whose name might have changed by the time this is relevant, is still in the house, McCarthy should ask him to sing a few songs.

For starters, according to Santos’s resume, he has won at least three Grammy awards, which means he has a wonderful and lyrical singing voice.

When things get too tense during deliberations with other Republicans, let alone the Democrats who are ruining the government and the country, McCarthy has a playlist for Santos. He’s going to sing the Meghan Trainor song, “Lips are Movin,” with a slight modification in the wording.“If my lips are moving, then I’m lyin’, lyin’, lyin’, baby.”

If things continue to be tense for hours, as a politician continues grandstanding, Santos can provide a Billy Joel encore, again with a slight tweak:

“Honesty is such a lonely word

I am certainly so untrue

Honestly is hardly ever heard

And rarely what I give to you.”

Following the example of Trump, McCarthy also agreed to hug a flag in public at least three times a year, to normalize the behavior and to demonstrate his commitment to America and the country’s values.

He also promised to support at least 13, for the original colonies, investigations in his first year as speaker, with a commitment to at least another dozen in his second.

Finally, in a subtle gesture meant to celebrate the political right, he planned to stand to the right of the podium and only to hit the gavel with his right hand while pausing to emphasize the word “right” every time he utters it.

CSHL’s David Spector (center) and postdoctoral fellows Rasmani Hazra on left and Gayan Balasooriya on right. Photo courtesy of CSHL

By Daniel Dunaief

One came from India, the other from Sri Lanka. After they each earned their PhD’s, they arrived on Long Island within seven months of each other about seven years ago, joining a lab dedicated to studying and understanding cancer. Each of them, working on separate projects, made discoveries that may aid in the battle against heart disease.

Working for principal investigator David Spector at Cold Spring Harbor Laboratory, postdoctoral fellow Rasmani Hazra, who grew up in Burdwan, India, found a link between a gene that affects cancer in mice that also can lead to a problem with the development of heart valves.

Hazra worked with two long noncoding RNAs that are highly expressed in mouse embryonic stem cells, which have the ability to differentiate into many different types of cells.

Specifically, she found that mice that didn’t have Platr4 developed heart-related problems, particularly with their valves.

At the same time, postdoctoral fellow Gayan Balasooriya, who was born and raised in Sri Lanka, discovered that a single, non-sex gene is governed by different epigenetic mechanisms based on whether the gene is inherited from the mom or the dad.

While it was known that males are more susceptible to heart disease than females, researchers did not know which copy of the gene related to those diseases are expressed. This discovery could help in understanding the development of heart defects.

“Although we ended up at heart development” in both of these published studies, “we didn’t initiate” looking for heart-related information, said Spector. “The science led us there.

Spector, however, expects that the lessons learned about differentiation in the context of the developing heart can also “impact out knowledge about tumors” which he hopes will eventually lead to advances in how to treat them.

He added that any clinical benefit from this work would take additional research and time.

An on and off switch

In Hazra’s study, which was published in the journal Developmental Cell, she worked with Platr4 because humans have several possible orthologous genes. 

When Platr4 expression, which shuts down after birth, is deleted from cells or embryos, the mice died from heart valve problems.

The human equivalent of Platr4 is located on chromosome 4. At this point, clinical case studies have connected the deletion of this chromosome to cardiac defects in humans.

Hazra said her project initially examined the function of these long non-coding sections of RNA. She was exploring how they affected differentiation. She found this link through in vitro studies and then confirmed the connection in live mice.

Spector explained that this work involved extensive collaborations with other researchers at Cold Spring Harbor Laboratory, including teaming up with researchers who can do electrocardiograms on mice and who can assess blood flow.

A shared mouse imaging resource also helped advance this research.

“One of the advantages of Cold Spring Harbor Laboratory is that we have over 10 shared resources, each of which specializes in sophisticated technologies that scientists can use on their own projects,” he said. Each lab doesn’t have to learn and develop its own version of these skills.

Hazra plans to continue to study other long noncoding RNA. She is also working on glioblastoma, which is a form of brain cancer.

Hazra plans to start her own lab next fall, when she completes her postdoctoral research.

Inactive gene

Balasooriya, meanwhile, published his research in the journal Nature Communications.

He used RNA sequencing to identify numerous genes. He also looked at whether the RNAs originated from the mom or dad’s genes in individual cells.

Also planning to start his own lab next fall, Balasooriya found changes that alter gene expression between the alleles from the mother and the father experimentally and through data mining approaches.

“What was most surprising in my studies is that [he identified] the gene from the father’s side and the mother’s side are regulated in a different manner,” Balasooriya said. “I’m interested in following up on that finding.”

The next step for him is to look not only at the heart, but, more broadly, at how monoallelic gene expression changes the way regulators affect development and disease.

“I want to do a deep dive to find out the mechanisms” involved in this expression of a single copy of the gene, Balasooriya said, which could provide ways to understand how to control the process.

In the long run, this kind of research could provide insights into ways to treat heart disease as well as other diseases like cancer and immune diseases.

Growing up in the North Western Province in Sri Lanka, Balasooriya was interested in math and science. After he finished his bachelor’s degree in biology in Sri Lanka, he earned a master’s in molecular biology at the University of Hertfordshire in England. He “got so excited about biology and exploring new fields” that he decided to pursue his PhD at the University of Cambridge, England.

After college, he worked in computer science for a while and realized he was not passionate about it, which encouraged him to do his master’s. The experience in computer science helped him with bioinformatics.

As for Spector, he is pleased with the work of both of his postdoctoral researchers. “This is what being a principal investigator is all about, having young people join your lab, sitting down with them, discussing a potential project, not really knowing where it’s going to go,” he said.

He described both members of his team as “extremely successful” who were able to make discoveries that they shared in prestigious journals. Balasooriya and Hazra both laid the groundwork to go and start their own careers. 

“Seeing the fruits of their work is the most rewarding experience” as the leader of a lab, Spector said.

Elon Musk. Pixabay photo

By Daniel Dunaief

Daniel Dunaief

Our story begins some time around now. No, there’s no chocolate, despite the season, and there’s no meadow where everything is edible.

No, our modern-day story begins where so much of us live these days, online.

You see, a famous and once marvelous company called Twitter is run by an eccentric, wealthy and successful businessman named Elon Musk, who somehow figured out how to create and mass produce electric cars that require no gas and that sound like spaceships.

Musk has decided, after many hours of running Twitter, that he needs to find a successor.

So, borrowing a page from Willy Wonka, he provides invitations that cost 3 cents per tweet to enter a sweepstakes.

When he narrows the field down to those who get the golden tweet, he plans to invite a group of five people to come to a virtual, top secret Twitter tour.

A few people try to make fake tickets, but the ever vigilant Musk spots the fraud. Day after day, people wait until, finally, five people, some of whom have never tweeted in their lives, have a chance to run the company.

Musk appears on screen wearing a top hat and a menacing smile. He demands that no one record what they see or take a screenshot of the secrets he is prepared to share.

Each person has a tiny image — about 1/4 the size of Musk’s — as they virtually walk through a factory floor.

On the first stop, Musk invites them to join him in the secret Hunter Biden/ New York Post room. Ah, yes, the story about the infamous laptop, which will undoubtedly become a part of an extensive investigation into the Biden progeny, is in this room.

“Don’t try to read anything!” he snaps.

But, of course, one of the contestants can’t resist. With a special tool that tracks eye movements, Musk knows that contestant No. 1, who is chewing gum constantly, is trying to decipher all the information. Her screen develops a horrible virus that turns it (and her entire computer) purple.

“You see?” he says, shaking his virtual head at the other small characters. “That’s what you get when you don’t listen. Oh, look, here they come now.”

Wearing virtual clothing embroidered with the Tesla logo, a modern day group of Oompa-Loompas appears on screen.

“Oompa, loompa, doompa dee do.

I’ve got another riddle for you.

Oompa loompa, doompa dee dee

if you are wise, you’ll listen to me.

What do you get when you don’t listen to Musk?

A virus on your computer that will kill it before dusk.

Who do you think should have the last laugh?

It certainly won’t be you or your staff.

Take a moment to ponder this fact,

Running Twitter may take too much tact.”

“Well,” Musk interrupts, waving away the virtual characters. “That’s enough of that. Now, let’s go for a virtual boat ride.”

In everyone steps as a boat careens through a choppy river, passing one door after another, with the names of celebrities who have been suspended hanging from each virtual room.

The boat stops near an embankment. The Musk character invites his guests to look at some special doors.

When he turns around, his virtual eyes widen in shock, his lower jaw drops down to his knees, and he hunches his shoulders.

“How? What? Wait, what’s going on?” he stammers, looking closely at the faces of his remaining four contestants.

Sure enough, on screen, Musk recognizes that two of the faces are the same as his, while the other two look like versions of Donald Trump.

“No, but, I made this game,” he whines. “How will we find out who wins?”

“Ah,” one of the Trumps says. “For that, you’ll have to tune into the sequel, which will only cost $99 and will become a collector’s item in no time.”

Isabella Rossellini ‘s new one woman show Darwin’s Smile reconciles two worlds that are often at the opposite ends: art and science. Photo by © André Rau/CSHL

By Daniel Dunaief

A model and actress, Isabella Rossellini has spent her life as a part of numerous stories. Nowadays, the 70-year old Rossellini, who has a home in Bellport, is eager to share the next chapter in her story-telling.

This time, Rossellini will bring her one-woman show “Darwin’s Smile,” which she originally wrote in French but will perform in English, to Cold Spring Harbor Laboratory’s Grace Auditorium for a two-day run on Saturday and Sunday, March 4 and 5, 2023.

Tapping into her love for animals, Rossellini plans to share her observations and insights about the nexus between her art as an actress and the science she studied and observed when she earned her Master’s Degree from Hunter College in animal behavior and conservation.

“What I would like to do is share my wonderment and stupor about information I learned” about animals, Rossellini said in a recent interview with Times Beacon Record News Media. “Science is notoriously difficult. The language is very enigmatic. Even to read Darwin is complicated. Once you get it, it’s really incredible.”

Indeed, Rossellini wrote the show as an extension of  the 1872 book by Charles Darwin titled Expression of the Emotions in Man and Animals, which was published 13 years after his famous On the Origin of Species.

Darwin studied a range of expressions from people all over the world and discovered that some of those expressions, such as smiling, responding to fear, or being disgusted, are the same regardless of the cultural background.

Darwin, Rossellini said, believed that evolution through natural selection shaped these expressions of emotion, the same way natural selection might affect a bone, the horns on a buck or the shape of a bird’s beak. The core of emotion across species appeals to her as an actress and as someone who appreciates and admires animals.

“Modeling is all about expression,” said Rossellini, who was the world’s highest paid model in 1982. “Yes, you have to be beautiful, and all this. What makes a good model is not so much beauty. People respond to emotion, rather than a beautiful nose or a beautiful mouth.”

As she did with her series of shorts called “Green Porno,” in which Rossellini dressed as creatures such as a praying mantis, shrimp, snails, spiders, and whales, among others, and described their mating, Rossellini uses humor to entertain and educate in “Darwin’s Smile.”

At one point, she dresses as a peacock with an attractive tail. Darwin, Rossellini said, found the brilliant colors of those feathers overwhelming, which gave him a headache.

Rossellini emerges from her peacock costume in another costume and sings a song, slowly, in French.

In her show, Rossellini uses her acting skills to convey emotions that use the same words. Repeating “I love you and I want to be with you all my life,” she shares that thought with rage, love and sadness, making it clear through her acting that humans derive meaning from a range of cues.

On a scientific level, Rossellini would like to challenge the idea that research into animals can’t include a recognition of their emotions. The science of behaviorism suggested that researchers shouldn’t “project any emotion into animals,” she said. Many scientists look, instead, directly at the behavior of animals.

“Darwin did not have that problem,” she said. He recognized that his dog was happy to see him and that a cat was angry.

As for the emotions she feels when she views her own acting performances, Rossellini suggested her experience mirrors that of many other actors and actresses. “It’s difficult to see oneself on screen in front of everybody,” she said. The mental image she has of herself sometimes conflicts with what she sees on screen.

“It’s very disturbing,” she said. “I don’t really like to watch my past work.”

The movies also create some melancholy for her, as they can evoke memories of her experiences during filming. She said the film “Blue Velvet” conjures thoughts of the time she and the cast, with whom she shared close friendships, worked together in Wilmington, North Carolina.

Sometimes she watches her movies twice. The first time, she adjusts to herself on screen. The second time, she follows the storyline and plot.

In terms of movies that came out this year, Rossellini said the film EO, which is about the life of a donkey who performs in a circus and then moves from one challenging circumstance to another, “makes you feel for the farm animal.” She described the film, which was made in Poland by director Jerzy Skolimowski, as “kind of beautiful.”

As for her life, Rossellini, who is the daughter of famed director Roberto Rossellini and actress Ingrid Bergman, said her interest in animals started when she was around 14 and her father gave her the book King Solomon’s Ring by Konrad Lorenz.  

When she read the book, she thought “this is what I want to be,” Rossellini said. Only later, after modeling and acting, both of which she continues to do, did she add ethology to the mix. 

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Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor will host a special performance of “Darwin’s Smile” at Grace Auditorium on March 4, with doors opening at 5 p.m. The show starts at 6 p.m., followed by a reception and Q&A with Rossellini led by Helen Hou, an assistant professor and neuroscientist at CSHL. 

An encore performance (sans Q&A and reception) will be held March 5, with doors opening at 3 p.m. and showtime at 4 p.m. For tickets, visit www.cshl.edu. For further information, call 516-367-8800.