By Daniel Dunaief

A significant concern for the elderly, falls create health problems that affect the quality of life and generate significant expense.

Stony Brook University’s Jeannette Mahoney, Professor of Neurology and Chief of the Division of Cognitive and Sensorimotor Aging in the Renaissance School of Medicine, has developed a smartphone app called CatchU that is designed to alert patients and their doctors to the potential likelihood of falls.

The National Institute of Aging (NIA) recently named CatchU as one of 21 finalists out of 275 entrants around the country for its Start-Up Challenge. As a finalist, Mahoney received $10,000, recently participated in entrepreneurial training sessions, and is receiving one on one mentorship.

“Falls are a leading cause of injury and death for older adults, including persons living with Alzheimer’s Disease,” Joy Toliver, Program Analyst at the National Institute of Aging explained. CatchU is a “novel approach” that has the potential to “expand access to high-quality, comprehensive fall risk assessments and to improve the health and quality of life of older adults.”

If CatchU is chosen as one of seven winners in the next stage of the challenge, Mahoney, through her company JET Worldwide Enterprises, is also eligible to receive $65,000.

Previous participants in a challenge that is now in its third year have gone on to raise significant equity funding, secure multiple grants and form partnerships with health systems to expand the impact of their solutions, Toliver added.

An ‘honor’

“I’m super stoked — it’s really such an honor to be selected by members of the NIA that believe in you, your science and your product,” Mahoney said.

She plans to use the prize money she’s received so far to help with app enhancements, legal fees for review of new service agreements, and exclusive license obligations.

The app links impaired multisensory integration, in which people combine information from visual and other cues, with poor motor outcomes. Mahoney has been working in this field for about a decade. Through a 10-minute health app that monitors reaction time as a person is asked to respond as quickly as possible to targets they can see, feel or see and feel at the same time, CatchU provides a quantitative risk for falls.

Across the country, about three million older Americans require an Emergency Room visit each year as a result of fall-related injuries.

Closer to home, Suffolk County residents from 65 to 74 are hospitalized at the rate of 106 per 10,000, while those number increase with each decade. From 75 to 84, residents require hospitalization at a rate of 311 per 10,000. People in the county who are over 85 visit hospitals after falls at the rate of 821 per 10,000, according to the Suffolk County Community Health Assessment and Improvement Plan.

For seniors over 75 years old in Suffolk County the hospitalization rate from falls exceeded that for the state exclusive of the city by more than 30 percent.

According to research Mahoney has done, older adults with poor multisensory integration are 24 percent more likely to fall than those with intact multisensory integration.

“We believe that results of the CatchU test will likely change over time for better or worse depending on levels of remediation,” she explained. “Our goal is to uncover what type of remediation (whether it is sensory, cognitive, or motor focused or some combination), and what duration/ frequency is most beneficial in subsequent clinical trials.”

Mahoney envisions using CatchU as a new standard of care for predicting fall propensity in adults 65 and over. Depending on performance, people could receive remote testing every six to 12 months.

Possible remediation

While people could download the app today, they wouldn’t be able to take the test without a provider code. Doctors would receive the results of their tests directly and could offer a range of recommended actions. This could include tai chi, physical therapy, core balance, strength training or other exercises.

Mahoney and her colleagues are running a clinical trial in Westchester County. The study attempts to determine whether integration measured on CatchU is comparable to integration measured on the lab apparatus. They submitted this research for publication.

The clinical trial also seeks to determine whether older adults with poor multisensory integration that receive feedback about their CatchU performance would go on to fall less often or have a longer time to fall compared to older adults with poor multisensory integration who did not receive any such specific feedback.

Alzheimer’s assessment

CatchU could provide beneficial information for people who might develop Alzheimer’s Disease.

From what Mahoney and her colleagues can tell, the same simple reaction time test taps into inter-related sensory, motor and cognitive neural circuits that are all affected by aging and/or disease.

Mahoney has shown that an ability to integrate sensory information is associated with higher amyloid burden, which is a known biomarker for Alzheimer’s Disease.

“Our current R01 project work will help us uncover the exact structural and functional neural correlates of impaired multisensory integration, which may shed light on the specific outcome measures that are adversely affected by poor integration,” Mahoney explained.

A returning Seawolf

Mahoney rejoined Stony Brook University in October, over 22 years after she graduated from the downstate flagship SUNY school with a bachelor of arts degree in Psychology and Social Science. She described coming back to campus as a “surreal” experience and appreciates how her colleagues have been“super helpful and supportive.”

Mahoney lives in upstate Stony Point with her husband Timmy, their 14 year-old daughter Kayleigh and 10-year old son Peter.

Mahoney formed the company JET Worldwide Enterprises almost exactly five years ago. It is based in Stony Point and has two employees. The company name, JET, comes from a nickname for Mahoney’s first name. If she is able to secure future funding, she hopes to move JET to incubator space at Stony Brook.

The family enjoys playing board games, including Mahjong. Mahoney learned the tile game from her mother, who learned it from Mahoney’s grandmother Jean Sissini.

Mahoney has dedicated CatchU to her grandmother, who passed away in 2021 after suffering a fall. 

While Sissini is no longer with them, the family knows she is “always with us in spirit,” Mahoney said.