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Power of 3

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Jeremy Borniger. Photo from CSHL

By Daniel Dunaief

Much as New Yorkers might want to minimize sleep, even during the pandemic when the need to be active and succeed is hampered by limited options, the body needs rest not only for concentration and focus, but also for the immune system.

Recently, Assistant Professor Jeremy Borniger, who joined Cold Spring Harbor Laboratory in January, collaborated with his former colleagues at Stanford University to publish research in the journal Science Advances that sheds light on the mechanism involved in this linkage.

Doctors and researchers had known for a long time that the release of glucocorticoids like cortisol, a stress hormone, can suppress the ability to fight off an infection. “That happens in people that are chronically stressed, even after surgery,” said Borniger in a recent interview.

A comprehensive understanding of the link between neuronal cells that are active during stress and a compromised immune system could help develop new ways to combat infections. The Stanford-led study provides evidence in a mouse model of the neuronal link between stress-induced insomnia and a weakened immune system.

Ideally, scientists would like to understand the neural pathways involved, which could help them design more targeted approaches for controlling the immune system using natural circuitry, according to Borniger.

Scientists could take similar approaches to the therapies involved with Parkinson’s, depression and obesity to increase or decrease the activity of the immune system in various disease states, instead of relying on a broader drug that hits other targets throughout the body.

In theory, by controlling these neurons, their gene products or their downstream partners, researchers could offer a way to fight off infections caused by stress.

While their studies didn’t look at how to gauge the effect of various types of sleep, such as napping or even higher or lower quality rest, their efforts suggest that sleep can help protect against stress-triggered infections.

The total amount and the structure of sleep play roles in this feedback loop. The variability among people makes any broad categorization about sleep needs difficult, as some people function well with six hours of sleep, while others need closer to eight or nine hours per day.

“Scientists are still working out how the brain keeps track of how much sleep it needs to rest and recover,” Borniger explained. “If we can figure this out, then, in principle, we could mess with the amount of sleep one needs without jeopardizing health.”

Researchers don’t know much about the circuitry controlling sleep amount. Borniger recognizes that the conclusions from this study are consistent with what doctors and parents have known for years, which is that sleep is important to overall health. The research also identifies a brain circuit that may be responsible for the way sleep buffers stress and immune responses.

People who have trouble sleeping because of elevated stress from an upcoming deadline often have a flare up of diseases they might have had under control previously, such as herpes viruses or psoriasis. These diseases opportunistically reemerge when the immune system is weakened.

The major finding in this study is not that the connection exists, but that the researchers, including principal investigator Luis de Lecea and first author Shi-Bin Li at Stanford, found the neural components.

While the studies of these linkages in the hypothalamus of mice were consistent across individuals, the same can’t be said for anecdotal and epidemiological evidence in humans, in part because the mice in the study were genetically identical.

For humans, age, sex, prior experiences, diet, family history and other factors make the linkage harder to track.

Even though researchers can’t control for as many variables with humans as they can with mice, however, several other studies have shown that stress promotes insomnia and poor immune function.

Borniger emphasized that he is the second author on the paper, behind Li and was involved in tracking the immune system component of the work.

Borniger and de Lecea are continuing to collaborate to see if drugs that target the insomnia neurons block the effect of stress on the immune system.

Now that he has moved into the refurbished Demerec Laboratory at CSHL, Borniger plans to work on projects to investigate how to use the nervous system to control anti-tumor immunity in models of breast and colorectal cancer, among others.

By understanding this process, Borniger can contribute to ways to manipulate these cells and the immune system to combat cancer and other inflammatory diseases.

Ideally, he’d like to be a part of collaborations that explore the combination of manipulating nervous and immune systems to combat cancer.

Borniger came to Cold Spring Harbor Laboratory because he was eager to collaborate with fellow scientists on site, including those who look at the immune system and metabolism. He appreciates how researchers at the famed research center look at how bodies and the brain respond to a growing tumor and would like to explore how tumors “influence nerves and then, reciprocally, how nerves influence tumor progression.”

The first few steps towards working at CSHL started in 2018, when Tobias Janowitz, Assistant Professor at CSHL, saw a paper Borniger published on breast cancer and asked him to give a 15-minute talk as a part of a young scholars symposium.

Borniger grew up in Washington, DC, attended college at Indiana University, went to graduate school at Ohio State and conducted his post-doctoral work at Stanford. Coming to CSHL brings him back to the East Coast.

Borniger and his fiancée Natalie Navarez, Associate Director of Faculty Diversity at Columbia University, met when they were in the same lab at Stanford. The couple had planned to get married this year. During the pandemic, they have put those plans on hold and may get married at City Hall.

Borniger and Navarez, who live on campus at Hooper House at CSHL, look forward to exploring opportunities to run, hike and swim on Long Island.

The new CSHL researcher appreciates the new opportunities on Long Island.

“This sort of collaborative atmosphere is what I would have in my Utopian dream,” Borniger said.

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Taken around 1890, the photo above includes Lucas Cheadle’s great, great grandparents Martin Van Buren Cheadle and his wife Mary Vera with their children, from left, Overton, Ellis, Lurena and Thomas (who is Cheadle’s great grandfather).

By Daniel Dunaief

In joining Cold Spring Harbor Laboratory, Lucas Cheadle has continued his professional and personal journey far from his birthplace in Ada, Oklahoma.

Then again, his travels, which included graduate work in New Haven at Yale University and, most recently, post doctoral research in Boston at Harvard Medical School, wasn’t nearly as arduous or life threatening as the forced trip his ancestors had to take.

In 1837, Cheadle’s great, great, great grandparents had to travel from Pontotoc, Mississippi to southern Indian Territory, which is now near Tishomingo, Oklahoma as a part of the Trail of Tears. Native American tribes, including members of Cheadle’s family who are Chickasaw, cleared out of their lands to make way for Caucasian settlers.

Lucas Cheadle

Proud of his biracial heritage, which includes Chickasaw, Choctaw, and Cherokee lineages, Cheadle hopes to make his mark professionally in his studies of the development of the brain (see article on page B). At the same time, he hopes to explore ways to encourage other members of the Chickasaw tribe to enter the fields of science, technology, engineering and mathematics.

One of three sons of a mixed Chickasaw father named Robert Cheadle and a Caucasian mother named Cheryl, Cheadle would eventually like to provide the kind of internship opportunities through his own lab that he had during his high school years.

Indeed, during the summer of his junior year, Cheadle did a health care internship, in which he shadowed different types of physicians. He watched active surgeries and observed a psychiatrist during patient visits. After that summer, Cheadle thought he might become a psychiatrist as well because he knew he was interested in the study of the brain.

Down the road, Cheadle envisions having one or two people learn as interns in the lab during the summer. Longer term, Cheadle hopes other investigators might also pitch in to provide additional scientific opportunities for more Native American high school students.

Growing up in Oklahoma, Cheadle never felt he stood out as a member of the Chickasaw tribe or as a biracial student.

His father, Robert, was active with the tribe, serving as a tribal judge and then as a legislative attorney for the Chickasaw. His grandfather, Overton Martin Cheadle, was a legislator.

Through their commitment to the Chickasaw, Cheadle felt a similar responsibility to give back to the tribe. “It was an incredibly important part of their professional lives and it was a passion” to help others, he said. “I’m driven by that spirit.”

His father took people in who had nowhere to go. In a few cases, people he put up robbed the family. Even after they robbed him, Cheadle’s father took them back. When Robert Cheadle died earlier this year, one of the people whom Cheadle supported helped out with his funeral arrangements.

Driven to accomplish his mission as a scientist, Lucas Cheadle feels he can reach out to help high school students and others interested in science during his research journey.

“The better I can do, the more I can help,” Cheadle said. He hopes to “open doors for other people.”

With some of these efforts to encourage STEM participation among Native Americans, Cheadle hopes to collaborate with John Herrington, a Chickasaw astronaut who took a Native American flute into space during one of his missions. “It would be wonderful to discuss this” with Herrington, “if he has time for me,” said Cheadle.

In modern times, the Chickasaw tribe has made “good strides” in being successful. One challenge to that success, however, is that it has included assimilation.“The main goal is to hold onto the heritage as much as we can,” said Cheadle.

As for now, he plans to honor his heritage in his lab by “working hard to create a safe, respectful environment where people’s unique backgrounds and characteristics are supported and embraced. I try to create a space where diversity can thrive.”

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Lucas Cheadle. Photo from CSHL

By Daniel Dunaief

One of the newest additions to Cold Spring Harbor Laboratory’s neuroscience program, Lucas Cheadle, who is an assistant professor, is exploring the early environmental factors at a molecular level that shape the neurological development of the mouse visual system.

While nature and nurture combine to produce the individuals each life form becomes, Cheadle is focused on the ways nurture, specifically, shapes the pathways in the brain that affect the development of sight.

Microglia are an unlikely player in this environmentally-triggered development, as doctors and researchers previously saw these cells primarily as participants in neurinflammation.

That is not the case anymore, with Cheadle and other scientists demonstrating over the past decade or so that microglia play important parts in the healthy brain. Cheadle, specifically, has demonstrated that these cells play a role in experience-dependent circuit development.

Indeed, the process of circuit refinement in the developing brain, which Cheadle describe as being among the “most complex structures in the known universe,” is akin to a room full of half-full boxes, which represent synaptic connections between neurons.

The brain begins with numerous little boxes that make the room difficult to navigate. As the brain consolidates the important items into a smaller number of larger boxes and removes the smaller boxes, the room becomes more manageable.

This is consistent with what Cheadle has seen during refinement. A smaller number of synapses become stronger and are maintained, while others are removed. This promotes the efficiency and precision of neural processing, he explained.

When the contents of some of those boxes disappear, however, the result can lead to neurodegenerative diseases like Alzheimer’s, in which a person struggles to find memories that may have been unwittingly cleared out.

Cheadle, who most recently was a post doctoral researcher at Harvard Medical School, is exploring the way microglia shape the connections between the eyes and the brain between when a mouse is born and when it reaches one month of age.

His work has shown that microglial cells are required for the sensory-dependent phase of visual circuit development. Disrupting signals between microglia and neurons affects synapse elimination, akin to removing the smaller boxes, which is important for circuit function.

Indeed, prior to work Cheadle and others have done in recent years with these cells in the brain, researchers thought microglia in the brain were quiescent, or inactive, after birth, except for their role in brain injury, disease pathology and neuroinflammation.

Until the first week of life, microglia engulf and then digest synaptic connections between some neurons, in a process called phagocytosis. During the sensory-dependent phase of refinement in the third week after birth, which Cheadle demonstrated in a paper published this month in the journal Neuron, microglia stop phagocytosis and rely on cytokines to break down synapses.

The cytokine pathway Cheadle discovered, called TWEAK, which is a ligand expressed by microglia, and Fn14, a receptor expressed by neurons, becomes active between eye opening, which is around two weeks, and peaks at about four weeks old.

When mice don’t have exposure to important visual stimuli during this critical period, the circuit has too many synaptic connections, which reduces the effectiveness of the developing visual system.

While Cheadle is working on visual development, specifically, he is interested in the broader implications of this work in the context of the environmental signals that affect the development of the brain.

In that broader context, the processes involved in autism and schizophrenia could reflect a period in which individuals have an overabundance of synapses that weren’t sufficiently pruned and refined.

Despite the fact that researchers hypothesized that synaptic pruning may lead to these disorders decades ago, they still have a limited awareness of whether and how this might happen. Studying the way microglia contribute to healthy circuit development could provide important clues about these processes.

Some epidemiological evidence points to the linkage between immune activity and neurodevelopmental disorders. In 1918 and 1919, during the Spanish Flu pandemic, children born during that period had a higher incidence of an autism or schizophrenia later in life.

Other evidence shows an interaction between immune activation and neurodevelopmental dysfunction, including the genetic loci associated with such disorders and increased inflammatory markers in the blood and brains of people with such disorders. “There’s really no question that there is a link,” Cheadle explained. “The nature of the link is still poorly understood.”

While earlier epidemiological data raises questions about the current pandemic, it doesn’t provide a definitive answer because “we still don’t quite understand what the nuanced molecular factors are that link the immune activation to the increase in disease prevalence,” Cheadle suggested.

“There’s a real chance that having COVID during pregnancy may impact the development of the offsprings’ nervous systems as has been seen in other infections,” Cheadle wrote. “While it is not the current priority of COVID research, it certainly warrants studying.”

Cheadle hopes to understand the “underlying principals of disorders” he said.

A resident of Huntington, Cheadle lives five minutes from the lab. He plans to rent for now because he didn’t want to start a new lab and move into a new house at the same time.

Cheadle has hired a technician and is in the process of hiring another. A post doctoral scientist will join his lab in November.

Early on in his life, Cheadle said he was fascinated with the interface between the world and biology. He wanted to understand how human brains interpret the information that comes from our senses. Everything culminated, professionally, in his interest in neurobiological mechanisms.

Currently, Cheadle is also interested in the looming behavior of mice. In the field, when mice see a bird that is flying slowly overhead, they are more likely to make a mad dash for safety, running into weeds or for cover from a tree. When the bird, however, is flying too rapidly, the mice freeze.

“I’m intrigued to find out whether the dichotomy of fight or flight could be shifted by the function of microglia,” he said. “I like to understand something at a functional level and dissect it to a molecular level.”

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James Misewich Photo from BNL

By Daniel Dunaief

Even as the pandemic continues to cast a pall over the prospects for the economy, the federal government is finding ways to support science. Recently, as a part of a $625 billion award to a host of institutions, the Department of Energy earmarked $115 million over five years for a part of a project led by Brookhaven National Laboratory.

The science, called quantum information systems, could have applications in a wide range of industries, from health care to defense to communications, enabling higher levels of artificial intelligence than the current binary system computers have used for decades. By benefiting from the range of options between the 0s and 1s that typically dictate computer codes, researchers can speed up and enhance the development of programs that use artificial intelligence.

The investment “underscores the confidence the federal government has with respect to how important this technology is,” said James Misewich, the Associate Laboratory Director for Energy and Photon Sciences at BNL. “Despite the challenges of the time, this was a priority.”

Local leaders hailed the effort for its scientific potential and for the future benefit to the Long Island economy.

“I have seen strong support inside of Congress and the administration for funding requests coming out of the Department of Energy for ideas on how to move the DOE’s mission forward,” said U.S. Rep. Lee Zeldin (R-NY-1). “I have also seen a very high level of appreciation and respect for BNL, its leadership, its staff, its mission and its potential.”

Zeldin said the average American spends more time than ever engaging with technologies and other discoveries that were made possible by the first quantum revolution. “Here we are on the verge of a second quantum revolution and BNL is at the forefront of it,” Zeldin said.

Zeldin sees limitless possibilities for quantum information science, as researchers believe these efforts will lead to advancements in health care, financial services, national security and other aspects of everyday life. “This next round of quantum advancements seeks to overcome some of the vulnerabilities that were identified and the imperfections in the first wave,” he said.

State Senator James Gaughran (D-Northport) expects quantum science to provide a significant benefit to the region. “We believe this is going to be a major part of our economic future,” he said. “It is a huge victory for Long Island.”

The return on investment for the state and the federal government will also materialize in jobs growth. This is “going to employ a lot of people,” Gaughran said. “It will help to rebuild the type of economy we need on Long Island. The fact that we are on the front lines of that will lead to all sorts of private sector development.”

While the technology has enormous potential, it is still in early enough stages that research groups need to work out challenges before they can fully exploit quantum technology. BNL, specifically, will make quantum error correction a major part of their effort.

As quantum computers start working, they run into a limitation called a noisy intermediate scale quantum problem, or NISQ. These problems come from errors that lower the confidence of getting the right answer. The noise is a current limitation for the best quantum computers. “They can only go so far before you end up with an error that is fatal” to the computing process, Misewich said.

By using the co-design center for quantum advantage, Misewich and his partners hope to use the materials that “beat the NISQ error by having the combination of folks with a great team that are all talking to one another.”

The efforts will use a combination of classical computing and theory to determine the next steps in the process of building a reliable quantum information system-driven computer.

Misewich’s group is also focusing on communication. The BNL scientists hope to provide a network that enables distributed computing. In classical computing, this occurs regularly, as computer scientists distribute a problem over multiple computers.

Similarly, with quantum computing, scientists plan to distribute the problem across computers that need to talk to each other.

Misewich is pleased with the combination of centers that will collaborate through this effort. “The federal government picked these centers because they are somewhat complementary,” he said. The BNL-led team has 24 partners, which include IBM, Stony Brook University, SUNY Polytechnic Institute, Yale University, Princeton University, the Massachusetts Institute of Technology, Harvard University, Columbia University and Howard University, among others.

“We had to identify the best team and bring in the right people to fill the gaps,” Misewich explained.

Using a combination of federal funds and money from New York State, BNL plans to build a new beamline at the National Synchrotron Lightsource II, which will operate at very low temperatures, allowing scientists to study the way these materials work under real word conditions.

BNL would like the work they are doing to have an application in calculations in three areas: the theory of the nucleus, quantum chemistry, which explores ways to design better materials, and catalysis.

A quantum computer could help make inroads in some challenging calculations related to electron-electron interactions in superconducting materials, Misewich said, adding that the entire team feels a “tremendous sense of excitement” about the work they are doing.”

Indeed, the group has been working together for close to two years, which includes putting the team in place, identifying the problems they want to tackle and developing a compelling strategy for the research to make a difference.

The group is expecting to produce a considerable amount of research and will likely develop various patents that will “hopefully transfer the technology so companies can start to build next generation devices,” Misewich said.

Along with local leaders, Misewich hopes these research efforts will enable the transfer of this technology to a future economy for New York State.

This effort will also train a numerous graduate and post doctoral students, who will be the “future leaders that are going to drive that economy,” Misewich said.

The research will explore multiple levels of improvement in the design of quantum computers which they hope will all work at the same time to provide an exponential improvement in the ability of the computer to help solve problems and analyze data.

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Anže Slosar. Photo from BNL

By Daniel Dunaief

Ever since Ancient Romans and Greeks looked to the stars at night, humans have turned those pinpricks of light that interrupt the darkness into mythological stories.

Two years from now, using a state-of-the-art telescope located in Cerro Pachón ridge in Northern Chile, scientists may take light from 12 billion light years away and turn it into a factual understanding of the forces operating on distant galaxies, causing the universe to expand and the patterns of movement for those pinpricks of light.

While they are awaiting the commissioning of the Vera C. Rubin Observatory, researchers including Brookhaven National Laboratory Physicist Anže Slosar are preparing for a deluge of daily data — enough to fill 15 laptops each night.

An analysis coordinator of the Large Synoptic Survey Telescope’s dark energy science collaboration, Slosar and other researchers from around the world will have a unique map with catalogs spanning billions of galaxies.

Anže Slosar

“For the past five years, we have been getting ready for the data without having any data,” said Slosar. Once the telescope starts producing information, the information will come out at a tremendous rate.

“Analyzing it will be a major undertaking,” Slosar explained in an email. “We are getting ready and hope that we’ll be ready in time, but the proof is in the pudding.”

The Vera C. Rubin Observatory is named for the late astronomer who blazed a trail for women in the field from the time she earned her Bachelor’s Degree from Vassar until she made an indelible mark studying the rotation of stars.

Slosar called Rubin a “true giant of astronomy” whose work was “instrumental in the discovery of dark matter.”

Originally called the Large Synoptic Survey Telescope (LSST), the Rubin Observatory has several missions, including understanding dark matter and dark energy, monitoring hazardous asteroids and the remote solar system, observing the transient optical sky and understanding the formation and structure of the Milky Way.

The study of the movement of distant galaxies, as well as the way objects interfere with the light they send into space, helps cosmologists such as Slosar understand the forces that affect the universe as well as current and ancient history since the Big Bang.

According to Slosar, the observatory will address some of its goals by collecting data in five realms including examining large structures, which are clustered in the sky. By studying the statistical properties of the galaxies as a function of their distance, scientists can learn about the forces operating on them.

Another area of study involves weak lensing. A largely statistical measure, weak lensing allows researchers to explore how images become distorted when their light source passes near a gravitational force. The lensing causes the image to appear as if it were printed on a cloth and stretched out so that it becomes visually distorted.

In strong lensing, a single image can appear as two sources of light when it passes through a dense object. Albert Einstein worked out the mathematical framework that allows researchers to make these predictions. The first of thousands of strong lensing effects was discovered in 1979. Slosar likens this process to the way light behind a wine glass bends and appears to be coming from two directions as it passes around and through the glass.

The fourth effect, called a supernova, occurs when an exploding star reaches critical mass and collapses under its own weight, releasing enough light to make a distant star brighter than an entire galaxy. A supernova in the immediate vicinity of Earth would be so bright, “it would obliterate all life on Earth.”

With the observatory scanning the entire sky, scientists might see these supernova every day. Using the brightness of the supernova, scientists can determine the distance to the object.

Scientists hope they will be lucky enough to see a supernova in a strongly lensed galaxy. Strong lensing amplifies the light and would allow scientists to see the supernova that are otherwise too distant for the telescope to observe.

Finally, the observatory can explore galaxy clusters, which are a rare collection of galaxies. The distribution of these galaxies in these clusters and how they are distributed relative to each other can indicate the forces operating within and between them.

The BNL scientist, who is originally from Slovenia, is a group leader for the BNL team, which has seven researchers, including post docs. As the analysis coordinator of the dark energy science collaboration, he also coordinates 300 people. Their efforts, he said, involve a blend of independent work following their particular interests and a collective effort to prepare for the influx of data.

Slosar said his responsibility is to have a big-picture overview of all the pieces the project needs. He is thrilled that this project, which was so long in the planning and development stage, is now moving closer to becoming a reality. He said he has spent five years on the project, while some people at BNL have spent closer to 20 years, as LSST was conceived as a dark matter telescope in 1996.

Scientists hope the observatory will produce new information that informs current understanding and forms the basis of future theories.

As a national laboratory, BNL was involved in numerous phases of development for the observatory, which had several different leaders. The SLAC National Accelerator in Stanford led the development of the camera that will be integrated into the telescope. BNL will also continue to play a role in the data analysis and interpretation.

“Fundamentally, I just want to understand how the universe operates and why it is like this and not different,” said Slosar.

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COVID-era Human Language Analysis Lab Meeting in July, top row from left, MZ Zamani, Matthew Matero, Nikita Soni ; bottom row from left, Adithya Ganesan, Oscjar Kjell, Linh Pham and H. Andrew Schwartz in the middle. Photos taken July, 2020

By Daniel Dunaief

Computers might not be able to tell you how they are doing, unless they run a diagnostic test, but they might be able to tell you how you are doing.

Using artificial intelligence, a team of scientists at Stony Brook University recently received a $2.5 million grant from the National Institutes of Health to study how social media posts and mobile phone data may be able to predict excess drinking among restaurant workers.

By using data from texting, social media and mobile phone apps, these researchers, led by Andrew Schwartz, an Assistant Professor in the Department of Computer Science, are hoping to use artificial intelligence to predict excessive drinking.

According to the National Institute of Alcohol Abuse and Alcoholism, unhealthy drinking involves seven drinks a week for women and 14 for men.

Schwartz said the study hopes to be able to address whether the researchers, including Richard Rosenthal, the Director of Addiction Psychiatry at Stony Brook Medicine and Christine DeLorenzo, Associate Professor in the Departments of Biomedical Engineering and Psychiatry, could “say what the mood predicts how much participants will be drinking in the future.”

By analyzing the content of texts and social media posts, Schwartz and a team that also involves scientists from the University of Pennsylvania will explore whether an increase in stress is more likely to happen before an increase in drinking.

The researchers will study the effect of empathy, which can be health promoting and health threatening. “We believe AI-behavior-based measures will work better than questionnaires for detecting an unhealthy style of empathy,” Schwartz explained in an email. The AI will search for non-obvious patterns of social media posts and texts to determine which type of empathy a person might demonstrate and whether that empathy could lead to a drinking spiral.

Empathy theoretically may add to stress for bartenders and restaurant workers as they often listen to customers who share their tale of woe with food service professionals and are also in a social job.

Indeed, amid the pandemic, where levels of stress are higher during periods of uncertainty about public health and in which restaurant workers might be more likely concerned about their employment, this study could provide a way to understand how increases in alcohol consumption develop potentially to inform new ways to interrupt a negative spiral. “The extra stress of job security is heightened right now” for restaurant workers, among others, Schwartz said.

By validating AI against accepted tools, the researchers hope to gauge the AI-decoded link between emotion and unhealthy drinking behavior by aligning what an individual is expressing in social media with indicators of their emotional state and drinking.

Participants in the study are filling out brief surveys several times a day.

In the long run, the scientists hope this kind of understanding will allow future public health professionals to offer support services to people without the cost of having to administer numerous questionnaires.

The researchers had received word that their proposal had received the kind of score from the NIH that suggested they would likely get funded last July. They could have received positive funding news any time from November through May, which was when they learned that they had secured the financial support to pursue their research.

The topic of study is “extremely relevant,” he added, amid the current uncertainty and the potential for a second wave in the fall or winter.

“We’re interested in studying how unhealthy drinking develops and how it plays out in people’s daily lives,” Schwartz said.

Social media provides a window into the emotional state of the participants in the research.

To be sure, the researchers aren’t looking at how people post about drinking, per se, online. Instead, the scientists are looking at how people in the study answer questions about their drinking in the regular questionnaires.

The researchers came together for this effort through the World Well Being Project, which is a research consortium in collaboration with scientists at the University of Pennsylvania, Stony Brook University and Stanford.

The project involves groups of computer scientists, psychologists and statisticians to develop new ways to measure psychological and medical well-being based on language in social media, according to the group’s web site, which describes “Authentic Happiness.”

In a recent study, 75,000 people voluntarily completed a personality questionnaire through Facebook and made their status updates available. Using these posts, the researchers were able to predict a user’s gender 92 percent of the time just by studying the language of their status updates.

Researchers in substance use approached the World Well Being Project, which Schwartz is a part of, about the topic of unhealthy alcohol use.

The Artificial Intelligence methods Schwartz is developing and that the scientists are testing through this grant are aimed at understanding how a person is changing their language over time through their digital footprint.

In the future, Schwartz believes this approach could contribute to personalized medicine.

“When someone is most at risk, apps that are validated [may be able to] detect these sorts of patterns,” he said. While this study doesn’t provide a personalized patient app, it should provide the tools for it, he explained.

Optimizing this work for false positive and false negatives is a part of this study. The researchers need to create the tools that can make predictions with minimal false positives and false negatives first and then hope it will be used to interact with patients.

In this type of artificial-intelligence driven work, researchers typically need about 500 words to come up with a conclusion about a person’s emotional state. A goal of this work is to get that number even lower.

Fotis Sotiropoulos, the Dean of the College of Engineering and Applied Sciences, offered his enthusiastic support for this effort.

Schwartz is blazing a trail in advancing AI tools for tackling major health challenges,” Sotiropoulos said in a statement. “His work is an ingenious approach using data-science tools, smart-phones and social media postings to identify early signs of alcohol abuse and alcoholism and guide interventions.”

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Ivar Strand Photo courtesy of BNL

By Daniel Dunaief

Ivar Strand had to put on a suit at home to interview virtually for a new job.

In the midst of the pandemic, Brookhaven National Laboratory was looking for a Manager of Research Partnerships in the Strategic Partnership Program and, despite the fact that the lab was limiting the people who were on site, was moving forward to fill a job opening.

“It was a strange situation,” Strand said, but the job piqued his interest, particularly because he’d be working with Martin Schoonen, the leader of BNL’s Strategic Partnership Programs office and an associate laboratory director for environment, biology, nonproliferation and national security. Schoonen and Strand, who worked together at Stony Brook in the late 1990’s, have known each other for over 25 years.

While Strand worked at Stony Brook as an Assistant Vice President of Sponsored Programs, he had a visiting appointment at BNL for five years, from 2005 to 2010. Several of the staff at BNL “remembered who I was, which made the transition a little bit easier,” he said.

Strand most recently worked at Long Island University, where he was the Executive Director in the Office of Sponsored Projects.

Schoonen was pleased to welcome Strand to the BNL fold. “[He is] taking on a pivotal role to develop contractual arrangements with potential partners and assist with growing and diversifying the labs funding sources,” Schoonen said in a statement.

In effect, Strand is facilitating collaborations among institutions. He will facilitate not only the connections and collaborations, but also encourage broadening and deepening professional connections to create either project specific or ongoing strategic partnerships

Strand will work to increase the awareness of the capabilities BNL can provide to researchers, entrepreneurs, and investors. The main drawback in a job he started on May 26 has been that he hasn’t been able to “build face-to-face relationships,” he said. Speaking with people for the first time through web-based platforms is not the same as running into someone who is walking across the site.

Building the relationship with the Department of Energy also represents a new challenge for Strand, who has previously worked with educational institutions as well as with Northwell Health.

“I spent my whole career building partnerships at various research institutions,” he said. After facilitating those collaborations, Strand has entered into agreements and then moved one. At BNL, he has the added dynamic of “making sure it satisfies the requirements of the DOE.” The scope of his work comprises all the research funding coming into the lab outside of the direct money that comes from the DOE, which represents about 90 percent of the funds for research at the lab.

Some of these other initiatives are collaborative, which involve DOE funds that also have a requirement to find a company to contribute financially, such as the Technology Commercialization Fund.

Working with finance and departmental business managers, Strand oversees the non-direct DOE money that comes in. When educational institutions and companies participate, particularly to supply funding, Strand and the strategic partnership team become a part of the conversation.

BNL often competes against the other national labs for major projects. Once the government selects a winner, as it did for the construction of the Electron Ion Collider, the DOE often asks the lead on the project to tap into the expertise and talents of the other institutions. When BNL recently won the EIC contract over Jefferson Laboratory in Virginia, the DOE asked BNL to partner with Jefferson to build the facility. New York State originally agreed to contribute $100 million to the construction of the EIC. Strand said the lab is hopeful that the commitment would come through.

In addition to the scientific discoveries that the EIC will bring, it is also a construction project that will provide the state with jobs. “I’m involved in some of the discussions in order to provide information about the project,” Strand said.

The transition to a government lab will require Strand to maneuver through structured agreements from the DOE, which is a bit of a challenge. The DOE uses structured agreements, while educational institutions also do but often are willing to use the agreements the sponsors propose.

Strand is pleased that BNL recently received approval to participate in the Atom Consortium, which was started by Glaxo and the University of California at San Francisco. The negotiation had been going on for several years. “It allows us to enhance our big data computing capabilities and expertise,” he explained.

Strand is excited about rejoining BNL. “I’ve always wanted to work in the lab and understand how best to build collaborations under the government umbrella,” he said.

Strand hoped his unconventional approach to some of the partnership challenges will work in the context of the structured environment of a national laboratory.

Indeed, in 2007, when he was working at Stony Brook, the university received the funds to buy a supercomputer. The two institutions, however, had decided to house the supercomputer at BNL, which made it a “challenging transaction” for all parties. He and others had to help Stony Brook become an enlisted partner, which allowed BNL to house the supercomputer on site.

In the bigger picture, Strand said he and Schoonen are reviewing where the lab will be from a strategic perspective in five years. In addition to industry, they are looking to collaborate with other federal sponsors with whom they haven’t traditionally partnered. They have to make sure that these efforts conform with DOE’s growth agenda.

A first-generation American whose parents were born in Norway, Strand said his parents met in the United States. A resident of South Setauket, Strand lives with his wife Maritza, who is an implementation specialist for ADT payroll. A tennis player and golfer, Strand alternates visiting and hosting his brother, who lives in Norway and is a veterinarian.

Strand is looking forward to his ongoing collaborations with Schoonen. “Having worked with him in the past, I have a lot of respect” for Schoonen, Strand said. “I jumped at the chance to be reunited with him. He’s an unbelievably great guy to work for.”

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Joel Hurowitz before the PIXL launch at the end of July. Photo by Tanya Hurowitz

By Daniel Dunaief

For six years, Joel Hurowitz worked as Deputy Principal Investigator on a team to build an instrument they would send to another planet.

Joel Hurowitz

An Assistant Professor of Geosciences at Stony Brook University, Hurowitz and the team led by Abigail Allwood at the NASA Jet Propulsion Laboratory created an instrument that would search for evidence of life that is likely long ago extinct on Mars.

The team designed a 10-pound machine (which will weigh less than four pounds in Mars’s lower gravity environment) that is about the size of a square lunchbox and houses x-ray equipment that can search along the surface of rocks for life that may have existed as long as three to four billion years ago.

Mars’s surface environment became less hospitable to life starting around three billion years ago, when the planet lost most of its atmosphere, causing the surface to dry out and become extremely cold. Surface life at this point likely became extinct.

Called the Planetary Instrument for X-ray Lithochemistry, or PIXL, the instrument was one of seven that lifted off at the end of July as part of a Mars 2020 mission. The Perseverance rover will land at the Jezero Crater on the Red Planet on February 18th, 2021.

After all that work, Hurowitz had planned to watch the launch with his family in Florida, but the pandemic derailed that plan.

“I got to watch the launch with my family,” Hurowitz said. He was on two zoom conferences, one with the Mars 2020 team and the other with members of the Department of Geosciences at Stony Brook. “It was a really special experience” and was the “best teleconference of the last six months,” he said.

As the rocket makes its 35.8 million mile journey to Mars, the JPL team will turn on the PIXL to monitor it, run health checks and do routine heating of the components to make sure it is operating. After the rocket lands, the rover will go through a commissioning period. Numerous subsystems need to be checked out, explained Hurowitz.

The first test for the PIXL will be to analyze a calibration target the researchers sent to Mars, to make sure the measurements coincide with the same data they collected numerous times on Earth. This ensures that the instrument is “working the way we want it to. That’ll happen in the first 40 sols.”

A sol is a day on Mars, which is slightly longer by about 40 minutes than a day on Earth.

Once it passes its calibration test, the PIXL can start collecting data. Hurowitz described the instrument as “incredibly autonomous.” It sits at the end of the rover’s arm. When the scientists find a rock they want to explore, the PIXL moves an inch away from the surface of the rock and opens its dust cover. The scientists take pictures with a camera and a set of laser beams. These beams help determine whether the PIXL is an optimal distance from the rock. If it isn’t, the instrument manipulates itself, using struts that allow it to extend or retract away from the rock.

Once PIXL gets in the right position, it fires an X-ray beam into the rock. The beam is about the diameter of a human hair. The x-ray that hits the rock is like wind going through chimes. Rather than make a familiar sound, the elements in the rock emit a specific x-ray signal as the atoms return to their ground state. Putting together the signals from the rock enables Hurowitz and the PIXL crew to determine its chemistry.

Even though the rocks are likely a combination of numerous elements, they “separate themselves cleanly in our spectra,” Hurowitz said. The SBU Geosciences expert expects the elements in the rocks to have different proportions than on Earth. Mars, for example, has more iron than sodium. A granite rock on Earth would likely have considerable sodium and some potassium, with a little iron.

Hurowitz and the PIXL team will be looking for rocks that may have evidence of prokaryotic organisms that are Mars’s versions of similar species found in undisturbed areas of Western Australia, where researchers discovered ancient fossilized life.

The rocks in Australia contain the oldest accepted fossilized forms of life, which are about 3.5 billion years old and are considered the best analogues for what the PIXL team might find on Mars.

In Australia, which is where Allwood grew up, scientists discovered microbial mats, which are single-celled organisms that build up, one layer after another, into a colony. These mats worked together to build up towards the sunlight, which fuels their metabolism. They use raw chemicals in the environment like dissolved sulfur, iron and manganese.

The Martian mats, if they find them, likely had to adapt to considerably different conditions than on Earth. The Martian environment may not have had large oceans or river systems and craters filled with lakes.

The scientists won’t be able to look for an individual microbe, but rather for indirect signals, such as laminated structures that formed in ways that are unique to microbial communities.

Hurowitz, Allwood and the PIXL team are looking for clues from an unusual lamination in the rock that they would likely associate with a microbial mat. By looking closely at the lamination, they may be able to develop hypotheses about whether a mat was taking chemicals out and depositing it to make a mineralized home for itself.

If they find rocks of interest, the rover’s drill will collect a sample and hermetically seal it in a tube.

A future mission to Mars, planned for 2026, could retrieve some of these samples, which, when they return, could confirm the presence of life on Mars. PIXL will continue to operate as long as the filament in the x-ray tube lasts, which should be between 1,300 and 1,400 uses.

Allwood, who shared an office with Hurowitz when they worked together at the Jet Propulsion Laboratory, said she approached him when she started assembling a team.

Finding life on Mars would answer a question that has intrigued those on Earth for thousands of years, Allwood said. Such Martian life would indicate that “we’re not alone. There was life and it was next door,” she said.

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DNALC Assistant Director Amanda McBrien teaches a live session. Photo by Chun-hua Yang, DNALC

By Daniel Dunaief

Two letters defined the DNA Learning Center at Cold Spring Harbor Laboratory over the last several months: re, as in rethink, reimagine, reinvent, recreate, and redevelop. They also start the word reagent, which are chemicals involved in experiments.

The 32-year-old Learning Center, which teaches students from fifth grade through undergraduates, as well as teachers from elementary school to college faculty, shared lessons and information from a distance.

At the Learning Center, students typically benefit from equipment they may not have in their schools. That has also extended to summer camps. “Our camps are built on this experiential learning,” said Amanda McBrien, an Assistant Director at the Learning Center.

DNALC Educator Dr. Cristina Fernandez-Marco, teaches a Genome Science Virtual Class. Photo by Sue Lauter, DNALC

While that part of the teaching experience is missing, the center adapted to the remote model, shifting to a video based lessons and demonstrations. Indeed, campers this year could choose between a live-streamed and an on-demand versions.

Dave Micklos, the founder of the Learning Center, was pleased with his staff’s all-out response to the crisis.

“The volume of new videos that we posted on YouTube was more than any other science center or natural history museum that we looked up,” Micklos said. “It takes a lot of effort to post content if you’re doing it in a rigorous way.” During the first few months of the lockdown, the Learning Center was posting about three or four new videos each day, with most of them produced from staff members’ homes.

As for the camps, the Learning Center sent reagents, which are safe and easy to use, to the homes of students, who performed labs alongside instructors. In some camps, students isolated DNA from their own cells, plant or animal cells and returned the genetic samples to the lab. They can watch the processing use the DNA data for explorations of biodiversity, ancestry and detecting genetically modified organisms.

The Learning Center has been running six different labs this summer.

The virtual camps allowed the Learning Center to find a “silver lining from a bad situation” in which students couldn’t come to the site, McBrien said. The Learning Center developed hands-on programs that they sent throughout the country.

McBrien said the instructors watched each other’s live videos, often providing support and positive feedback. Some people even watched from much greater distances. “We had a few regulars who were hysterical,” McBrien said. “One guy from Germany, his name is Frank, he was in all the chats. He loved everything we did” and encouraged the teachers to add more scientific lessons for adults.

McBrien praised the team who helped “redevelop a few protocols” so high-level camps could enable students to interact with instructors from home.

A DNA Barcoding Virtual Camp featuring DNA Learning Center Educator Dr. Sharon Pepenella, with her virtual class. Over Pepenella’s shoulder is a picture of Nobel Prize winners Francis Crick and James Watson. Photo by Sue Lauter, DNALC.

Using the right camera angles and the equipment at the lab, the instructors could demonstrate techniques and explain concepts in the same way they would in a live classroom setting. To keep the interest of the campers, instructors added polls, quizzes and contests. Some classes included leader boards, in which students could see who answered the most questions correctly.

This summer, Micklos and Bruce Nash, who is an Assistant Director at the Learning Center, are running a citizen science project, in which teams from around the country are trying to identify ants genetically throughout the United States.

Using a small kit, one reagent and no additional equipment, contributing members of the public, whom the Learning Center dubs “Citizen Scientists,” are isolating DNA from about 500 of the 800 to 900 species of ants.

In one of the higher level classes called metabarcoding or environmental DNA research, teachers collected microbes in a sample swabbed from their nose, their knees, tap water, and water collected from lakes.

The Learning Center supports this effort for high school research through Barcode Long Island, which is a partnership with the Hudson River Park to study fish in the Hudson. High school interns and the public help with sampling and molecular biology.

“Much like barcoding, we aim to democratize metabarcoding,” Nash explained in an email. A metabarcoding workshop that ended recently had participants in Nigeria, Canada, Antigua and distant parts of the United States, with applicants from Asia.

After teaching college faculty on bar coding, Micklos surveyed the teachers to gauge their preference for future courses, assuming in-person meetings will be possible before too long.

When asked if they would like in-person instruction only, a hybrid model, or classes that are exclusively virtual, none of the teachers preferred to have the course exclusively in person. “People are beginning to realize it is more time efficient to do things virtually,” Micklos said.

Nash added that the preference for remote learning predated the pandemic.

Micklos appreciates the Learning Center’s educational contribution. “To pull these things off with basically people talking to each other via computer, to me, is pretty amazing,” he said.

Around four out of 10 students who enter college who have an interest in pursuing careers in science continue on their scientific path. That number, however, increases to six out of 10, when the students have a compelling lab class during their freshman year, Micklos said.

Lab efforts such as at the Learning Center may help steady those numbers, particularly during the disruption caused by the pandemic.

The longer-term goal at the Learning Center, Micklos said, is to democratize molecular biology with educational programs that can be done in the Congo, the Amazon or in other areas.

As for the fall, the leadership at the center plans to remain nimble.

The Learning Center is planning Virtual Lab field trips and will also continue to offer “Endless Summer” camp programs for kids and parents looking for science enrichment.

The Center also hopes to send instructors for in-person demonstrations at schools, where they can host small groups of student on site.

“We are supporting as many people as possible through our grant-funded programs and our (virtual) versions of camps and field trips,” Nash said. “These will be adapted to support schools and others to progressively improve them through the fall, with the hope of reaching all those we would normally reach.”

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Klaus Mueller (third from left) with Akai Kaeru co-founder Eric Papenhausen (right) and interns Shenghui Cheng (second from left), on whose PhD thesis the software was based and Darius Coelho, who earned his PhD in Mueller’s lab. Photo courtesy of Akai Kaeru

By Daniel Dunaief

About 40 percent of the counties in the United States are at high risk for COVID-19 and related death rates, according to a new computer program created by Stony Brook University Computer Science Professor Klaus Mueller.

Putting together data from the over 3,000 counties throughout the United States, Mueller used a computer program he created with a start up company he co-founded, called Akai Kaeru LLC, to search for counties that present factors that would put them at greater risk for an increase in COVID-19 deaths.

Analyzing data from 500 factors, the scientists found that death rates increased in communities with a combination of traits that are catalytic for the spread and fatality rate of the virus. These include sparsely populated counties with a poor and aging population; counties with sleep-deprived, low-educated, low-insured residents; and wealthy counties with high home ownership and increasing housing debt, among other factors.

Many of the counties are in the southern United States. In June, Mississippi, Louisiana and Georgia had the highest density of high-risk counties at a coverage of 80 to 90 percent.

Mueller said he considered this approach in late April. When the data from the Centers for Disease Control and Prevention came online, the group did its first test run on May 10th, which ended on June 10th.

When he looked at the June 10th mortality rates throughout the country, he was amazed at how effectively the patterns based on the conditions from the computer algorithm predicted increases.

To be sure, not all of the counties that fit one or more of these sets of conditions had high death rates in May, but others that were similar had. The preconditions existed, but the spark to cause those deaths hadn’t occurred, Mueller said.

“In June, some of these so far untouched counties caught the virus and they flared up like a tinderbox,” Mueller explained in an email. “This phenomenon continued in July for other counties that had escaped it so far but had the critical condition sets.”

In June, some of the counties that had characteristics that made them vulnerable caught the virus, Mueller explained.

Mueller anticipates a rapid increase in August in counties in Florida and Texas, in which the virus has spread and the conditions for increased mortality are prevalent.

“There are counties in these states that from the socio-economic perspective look a lot like those that already experienced great tragedy,” he wrote.

Mueller explained that people in many counties think they’re not at risk even if their neighbors are. The danger, however, comes from a spark, such as a visit by someone carrying the virus, that increases the infection, hospital and mortality rates.

Indeed, in wealthy counties where residents are stretched thin by the costs needed to maintain their homes, the incidence of illness and death is also higher. In part, that reflects how some of the people in these communities cut corners in terms of health insurance.

Mueller said Akai Kaeru, which means “red frog” in Japanese, is working on a dashboard that will be accessible from a web browser where users can click on a map of counties and see the risk and the patterns that define it. The staff at Akai Kaeru, which includes three principals and four interns, have virtual team meetings each weekday at 11 am. The dashboard they create can help residents see the other counties that share similar characteristics. Users can also compare the death rate in these counties to the average death rate in the United States.

While the observations of trends linking characteristics of a county with COVID-related health challenges could be useful for county and state planners, Mueller acknowledged that these observations are “just a start. Now, you know where to look, which is way better than before.”

The data could be useful for policy and law makers as well as for actuaries at life insurance companies.

Mueller believes this artificial intelligence tool acts like a magnet that pulls out the proverbial needle from the data haystack.  Local leaders can use the dashboard to see the critical conditions for their counties. They can try to find solutions to remove those conditions.

Demonstrating how the health care system in similar areas became overwhelmed can increase compliance with social distancing and mask-wearing guidelines.

Mueller added that the predictions from the model are only as good as the data he used to analyze trends across the country. He and his team aren’t making these observations or collecting this information themselves.

He said some counties have a lower likelihood than the average of developing a wider contagion. While the entire state doesn’t have the same lower probability of the disease spreading, areas like Montana and Indiana have fewer of the variables that typically combine to create conditions that favor the spread of the virus.

Mueller suggests that the risks from COVID-19 are tied to compliance with policies that reduce the spread of the disease and to the development of a vaccine.

Despite the high infection rate through April and May and the deaths during those unprecedented months, Suffolk County isn’t at the same level of risk as some regions in the south. “Suffolk is much better than those counties in the South and even Westchester, Rockland and adjacent counties in Connecticut and New Jersey,” Mueller said. “But it is not without risk.”

Prior to developing a program to analyze epidemiological trends with COVID, Mueller worked with medical visualization, which included the three-dimensional data of human parts that were generated through computed tomography, or CT.

In his work, the Computer Science professor seeks to find ways to communicate high-dimensional data to the lay population. He has routinely worked on clustering and has partnered with Pacific Northwest, Brookhaven National Laboratory, and health care companies.

Mueller has been at Stony Brook University since 1999. He earned his PhD from Ohio State University. Originally from Germany, he has done considerable work online, including teaching.

He and his wife Akiko, who works on marketing for his company, have an eight-year-old daughter named Nico.

Readers interested in learning more about his research with COVID can find information at the following link: https://akaikaeru.com/covid-19-1.

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