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Richard Moffitt, who joined Stony Brook University’s Biomedical Informatics and Pathology departments at the end of July, recently contributed to an extensive study of pancreatic cancer. Photo by Valerie Peterson

By Daniel Dunaief

It may take a village and then some to conquer pancreatic cancer, which is pretty close to what The Cancer Genome Atlas project assembled.

Pulling together over 200 researchers from facilities across the United States, the TCGA recently published an article in the journal Cancer Cell in which the scientists explored genetic, proteomic and clinical information from 150 pancreatic cancer patients.

Richard Moffitt, an assistant professor in the Departments of Biomedical Informatics and Pathology at Stony Brook University who joined the institution at the end of July, was the analysis coordinator for this extensive effort.

The results of this research, which worked with pancreatic ductal adenocarcinoma, the most common form of this cancer, offered a look at specific genetic changes involved in pancreatic cancer, which is the third leading cause of death from cancer.

“The study has several immediate clinical implications for patients facing the diagnosis of pancreatic cancer,” Ralph Hruban, one of the corresponding authors on the article and the director of the Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins University School of Medicine, wrote in an email.

The work “provides hope for future clinical trials in that 42 percent of patients within this cohort had cancers with at least one genetic alteration that could potentially be therapeutically targetable, and 25 percent of the patients had cancers with two or more such events.”

These genetic findings suggest a potential basis for genetic change-driven therapy trials down the road, Hruban suggested. As the analysis coordinator, Moffitt “played a critical role” Hruban continued. “He brought hard work, amazing creativity and great scientific knowledge to the project.”

Moffitt joined this effort about four years ago, after the collaboration began. The assistant professor said he pulled together the various data sets and analysis results from different teams and helped turn that into a “coherent overall story.”

Moffitt was also in charge of the messenger RNA analysis. He had been at the University of North Carolina as a postdoctoral researcher in Vice Chair of Research Jen Jen Yeh’s lab for the last five years until his recent move to Stony Brook.

Benjamin Raphael, another corresponding author on the article and a professor in the Department of Computer Science at Princeton University, suggested Moffitt played a critical part in the recent work. “In any large-scale collaboration such as this one, there tend to be a smaller number of researchers who play an outsized role in the project,” Raphael explained in an email. Moffitt “played such an outsized role. Without his dedication to the project over the past few years, it is doubtful that our analysis” would have been as comprehensive.

Members of TCGA contacted Moffitt and Yeh because the tandem were working on a new approach to studying gene expression that would eventually be published in a 2015 Nature Genetics article.

Working with Yeh, Moffitt helped tease apart the genetic signature of pancreatic cancer cells from the different types of cells around it, which also includes healthy cells and a cluster of dense cells around the tumor called the stroma.

“The proportion of cancer cells in pancreatic cancer is low so if you imagine a mix of marbles of the same color on the outside but different on the inside and only having 10 in a bag of 100, figuring out what 10 [are] ‘tumor’ colors on the inside was very challenging,” Yeh explained in an email.

The TCGA study explains subtypes of cancer Moffitt didn’t know existed just a few years ago, while exploring the possible role that micro RNA and DNA methylation — the process of adding or taking away a methyl group from a genetic sequence to turn on and off genes — has in describing those subtypes.

Researchers “need projects like TCGA that are a really well-controlled way to study almost every molecule you want to study systematically for 150 cases to reveal these networks,” Moffitt said.

Moffitt has coupled his appreciation for algorithms and math with an interest in biology and engineering. His Ph.D. was done in a dry lab, which didn’t even have a sink. When he moved to UNC to conduct his postdoctoral work, he took a different approach and worked with surgical oncologists on tissue samples.

Moffitt plans to continue working with TCGA data and also to see how the subtypes can be used to predict responses to therapies. Some time in the future, researchers hope patients can get a diagnostic biopsy that will direct them to the specific therapy they receive, he said.

Moffitt grew up in Florida and earned his bachelor’s and doctoral degrees at Georgia Tech before completing his postdoctoral research at UNC. He has been gradually drifting north. Moffitt and his wife Andrea, who just started her postdoctoral work with Michael Wigler and Dan Levy at Cold Spring Harbor Laboratory, live in Stony Brook.

A competitive water skier during his youth in Florida, Richard Moffitt, dons two skis when he’s out with friends on Lake Oconee, Georgia in 2013. Photo by Andrea Moffitt

The water on Long Island is colder than it is in Florida, where Moffitt spent considerable time on a show skiing team. This was his version of a varsity sport, where he spent about six hours a day on Saturday and Sunday during the spring and about three hours a night before tournaments performing moving pyramids, among other tricks. When he was in high school, Moffitt wrote a computer program that automates the show skiing scoring process.

Moffitt processes the world through probabilities, which figured into the way he chose stocks in high school as a part of a stock picking competition and the way he approached his picks for March Madness. His basketball bracket won a competition for bragging rights among about a dozen entrants in 2016 and he was one game away from repeating in 2017 until UNC beat Gonzaga.

As for his Stony Brook effort, Moffitt plans to collaborate with members of the Cancer Center as well. “Being in demand is a good thing.”

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Brookhaven Town Supervisor Ed Romaine will seek re-election in November. File photo by Alex Petroski

Off-campus housing riddled with town code violations and unsafe conditions for Stony Brook University students has plagued Three Village residents for years. In 2013, the situation inspired community residents Bruce Sander and Anthony DeRosa to start the nonprofit organization Stony Brook Concerned Homeowners.

Coordinated with the start of a new school year, Brookhaven Town Supervisor Ed Romaine (R) delivered a clear message to landlords who rent to university students within his jurisdiction during a press conference Sept. 8: follow town building and fire safety codes or face consequences. The town and university presented a united front from Stony Brook Fire Department Sub Station 2 and stated their intentions to ensure students who reside in off-campus housing are safe in homes that meet town and state codes.

“We have codes for a reason — to protect health and safety,” Romaine said. “We are going to protect the health and safety of the students.”

The supervisor said many of the illegal rooming houses where students live have been subdivided into as many as 10 bedrooms, and a home on Christian Avenue, which he called the “showpiece” of illegal homes, had at least 16 occupants. Romaine said the house is now in foreclosure.

Brookhaven Councilwoman Valerie Cartright (D-Port Jefferson Station) said it is important that renters in the town know their rights when dealing with landlords, and she said town officials are available to assist renters who feel they are in an unsafe situation.

“The supervisor and I cosponsored a number of resolutions over the years to improve the quality of life of residents and to improve the safety of the residents renting here in the Town of Brookhaven,” she said. “Over the past two years or so we have a had a number of roundtable discussions with Stony Brook University, the supervisor’s office, Stony Brook Concerned Homeowners, and of course, our law department and planning department, to make sure we are addressing this issue, as it is a very important issue in our community.”

Bruce Sander of Stony Brook Concerned Homeowners thanked Brookhaven Town and SBU for their efforts in curbing illegal rentals. Photo by Alex Petroski

Deputy Town Attorney Dave Moran said there has been an increase in foreclosures in the community not due to financial reasons but due to the enforcement of building codes.

“We have broken [landlords’] business models in some circumstances, where it is no longer profitable for them to own their second and third house and collect those thousands in rents, by enforcing the statutes that we’ve put in place, by monitoring the rental permits and complaints that come in,” Moran said.

Moran said the town has collected $211,000 in fines over the last month for building violations, compared to only $300,000 collected for the entire year in 2008.

He said partnering with the university, which has educated students on their rights, has helped in uncovering issues as more students are contacting the town to report violations by their landlords.

Judith Greiman, chief deputy to the president of Stony Brook University and senior vice president for government and community relations, said the university has the most beds of any SUNY campus and are second among all universities in the state. The university added 759 new beds this past year with the opening of Chavez and Tubman residence halls and an additional 173 new beds will be available in the fall of 2018.

The chief deputy said the university has taken great steps to ensure students’ safety thanks to the input received from the community and support Romaine, Cartright, Brookhaven Town code inspectors and others have provided.

Among measures the university has undertaken since March 2013 are prohibiting advertisements of off-campus rentals on SBU’s website, unless the landlord can provide a Brookhaven Town rental permit, and prohibiting posting on campus bulletin boards. The university also holds tenants’ rights workshops to help students understand what to look for when renting.

Sander was on hand for the conference representing the Stony Brook Concerned Homeowners organization, and he commended the town and the university for their efforts.

“Unfortunately there will always be those landlords who still believe in the secret method of evading the laws and endangering the students and their community,” Sander said. “I’d like to send a message to the housing landlords: obey the laws.”

The organization founder said there should be no more than four people in a home. He said landlords can also do their part by maintaining their property, mowing grass weekly and providing garbage cans and enough parking space in driveways for tenants.

When it comes to circumventing the law, Romaine had a warning for landlords.

“Don’t do it, we’re coming for you,” he said.

Additional reporting by Alex Petroski

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Stony Brook University students show their support for those protected by DACA. Photo from Stony Brook University

As President Donald Trump (R) proposed to rescind the Deferred Action for Childhood Arrivals program, Stony Brook University community members and students voiced their support for the DREAMers — the name given to the approximately 800,000 undocumented immigrants that were brought to the United States as children.

University President Dr. Samuel L. Stanley Jr. stated his and the institution’s continued support of DACA in a Sept. 5 email sent to the campus community.

“We have seen how the recipients of DACA have a positive impact on our campus and broader community,” Stanley said. “Diversity of perspectives, thought and understanding serves as a foundation of Stony Brook’s academic enterprise and helps our students become global citizens. Let’s do what’s right, and unite to support our ‘dreamers’ together.”

Two days later, more than 200 students, faculty members and administrators united in the March for DREAMers rally to show undocumented students at the university their support. In addition, the marchers presented a letter to administrators listing further actions they hope the university will take.

Marchers show signs they brought to the March for DREAMers rally at Stony Brook University Sept. 7. Photo from College Democrats

Members of the Feminist Majority Leadership Alliance, an equality advocacy group, were among the rally’s organizers. The group’s Vice-President David Clark felt it was important to stand up for classmates who may feel vulnerable now.

“I wanted to, first of all, raise awareness of the concerns of DACA recipients and DREAMers on campus and also to show support of them on campus,” he said.

Clark said participants were thankful for the institution’s support of undocumented students and appreciated the university’s current stance on DACA, and Stanley’s statement that the campus should be considered a sensitive location by U.S. Immigration and Customs Enforcement.

Clark said the marchers were joined by representatives of non-campus groups including the Islandia-based SEPA Mujer, a not-for-profit organization dedicated to the empowerment of Latina immigrant women.

The college junior said administrators cooperated in securing a ballroom in the student activity center where participants gathered for speeches after walking around a circle and congregating in the main academic mall’s plaza. He said chants included,

“Say it loud. Say it clear. Dreamers are welcomed here.” Marchers held signs with messages that included, “Undocumented and unafraid” and “Sin DACA, Sin Miedo,” which in Spanish means, “Without DACA, without fear.”

Clark was satisfied with the turnout of the peaceful protest.

“I was really happy that so many Stony Brook students care about their fellow classmates, friends who are undocumented, who are getting through a very hard time right now, a time of uncertainty for them,” he said.

In their letter, marchers asked the university to ensure SBU would not provide information to ICE about any undocumented students or their families, not allow ICE to take students into custody without a judicial warrant, and to let students know if ICE is on campus through the university’s alert systems. The organizers also asked that a list be available on the website of the Office of Financial Aid and Scholarships to notify those who are not citizens where private scholarships may be available to them.

Stanley said in his Sept. 5 email that the university does not request or require immigration status as part of the admissions process. He added that immigration status is not a factor in student housing decisions, and the university does not share private information.

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Above, Ken Dill shows how molecules fold and bind together. Photo from SBU

By Daniel Dunaief

The raw materials were here. Somehow, billions of years ago, these materials followed patterns and repeated and revised the process, turning the parts into something more than a primordial soup.

Ken Dill, who is a distinguished professor and the director of the Laufer Center for Physical and Quantitative Biology at Stony Brook University, took a methodical approach to this fundamental development. He wanted to understand the early statistical mechanics that would allow molecules to form long chains, called polymers, which contained information worthy of being passed along. The process of forming these chains had to be self-sustaining.

After all, Dill said, many activities reach an end point. Putting salt in water, for example, creates a mixture, until it stops. Dill, however, was looking for a way to understand auto-catalytic or runaway events. Lighting a forest fire, for example, is much more self sustaining, although even it eventually stops. Life has continued for over four billion years.

On Aug. 22, Dill, Elizaveta Guseva and Ronald Zuckermann, the facility director in biological nanostructures at the Lawrence Berkeley National Laboratory, published a paper in the journal Proceedings of the National Academy of Sciences (PNAS).

The researchers developed a fold and catalyze computational model that would explain how these long chains developed in a self-sustaining way, in which hydrophilic and hydrophobic polymers fold and bind together.

Random sequence chains of each type can collapse and fold into structures that expose their hydrophobic parts. Like a conga line at a wedding reception, the parts can then couple together to form longer chains.

These random chemical processes could lead to pre-proteins. Today’s proteins, Dill said, mostly fold into a very particular shape. Pre-proteins would have been looser, with more shape shifting.

The workhorses of the body, proteins perform thousands of biochemical reactions. Dill suggested that this model “rates high on the list” in terms of the findings he’s made over the course of his career.

Zuckermann described this work as significant because it lays out predictions that can be tested. It highlights the importance of chemical sequence information in polymer chains and “how certain sequences are more likely to fold into enzyme-like shapes and act as catalysts than others,” he explained in an email.

Zuckermann works with substances he figured out how to make in a lab that are called peptoids, which are non-natural polymers. These peptoids are a “good system to test the universality of [Dill’s] predictions,” he said.

The “beauty” of Dill’s work, Zuckermann suggested, is that “it should apply to most any kind of polymer system” where researchers control the monomer sequence and include hydrophobic and hydrophilic monomers in a particular order, putting Dill’s predictions to the test.

For her part, Guseva worked in Dill’s lab for her PhD thesis. She had started her research on something that was “more standard physical biology” Dill said, but it “was not turning out to be particularly interesting.”

The scientists had a discussion about trying to develop a chemical model related to the origins of life. While exciting for the scope of the question, the research could have come up empty.

“There was so much potential to fail,” Dill said. “I feel pretty uncomfortable in general about asking a graduate student to go in that direction, but she was fearless.”

Dill and Zuckermann, who have collaborated for over 25 years, are trying to move forward to the next set of questions.

Zuckermann’s efforts will focus on finding catalytic peptoid sequences, which are nonbiological polymers. He will synthesize tens of thousands of peptoid sequences and rank them on how enzyme-like they are. This, he explained, will lead to a better understanding of which monomer sequences encode for protein-like structure and function.

Zuckermann suggested that the process in this research could have the effect of transforming a soup of monomers into a soup of functional polymers. This, he said, might set the stage for the evolution of DNA and RNA.

Proteins could have been a first step towards a genetic code, although life, as currently defined, would not have blossomed until a genetic code occurred, too, Dill suggested.

The origins of DNA, however, remains an unanswered question. “We’re trying to think about where the genetic code comes from,” Dill said. “It’s not built into our model per se. Why would biology want to do a two polymer solution, which is messy and complicated and why are proteins the functional molecules? This paper doesn’t answer that question.”

Dill and Zuckermann are in the early stage of exploring that question and Dill is hopeful he can get to a new model, although he doesn’t have it yet.

Dill moved from the University of California at San Francisco to join the Laufer Center about seven years ago. He appreciates the freedom to ask “blue sky questions” that he couldn’t address as much in his previous work.

Wearing a hat from his native Oklahoma, Dill, in a photo from around 1997, tinkers with a toy boat he made with sons Tyler and Ryan. Photo by Jolanda Schreurs

A resident of Port Jefferson, Dill lives with his wife Jolanda Schreurs, who has a PhD in pharmacology. The couple has two sons, Tyler and Ryan.

Tyler graduated with a PhD from the University of California at San Diego and now works for Illumina, a company which which makes DNA sequencers. Ryan, meanwhile, is earning his PhD in chemistry from the University of Colorado and is working on lasers.

“We didn’t try to drag our sons into science,” Dill said. “With both kids, however, we had a workshop in the basement” where they often took anything that was within arm’s reach and nailed it to a board. One of the finished products was a remote-controlled and motorized boat.

As for his lab work, Dill is thrilled to have this model that he, Guseva and Zuckermann provided, while he recognizes the questions ahead. Scientists “see something puzzling and, rather than saying, ‘I need to avoid this, I don’t have an answer,’ we find it intriguing and these things lead from one step to the next. There tends to remain a huge number of super fascinating problems.”

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Dr. Samuel L. Stanley Jr., Stony Brook University president, helps a student move into a residence hall Aug. 25. Photo from Stony Brook University

By Rita J. Egan

Stony Brook University has been doing its part to make campus life feel more like home for most students, by offering gender-inclusive housing.

For a decade, the option has allowed students to share a room with friends or siblings no matter what their gender, or choose housing based on the gender they identify with. The only requirements are that students have to be 18 or older and sign a contract stating they will respect everyone in their residence hall.

On Aug. 25, move-in day for freshmen and transfer students, resident assistant Derrick Wegner, who is transgender, was on hand to greet newcomers. The senior psychology major said he was happy to have the option when he came to Stony Brook. Wegner, who lives in Wurtsboro,  said college is a great opportunity for a fresh start, especially for young people looking to transition. 

Derrick Wegner stands in the gender-inclusive room he shares with his best friend Sydney. Photo by Rita J. Egan

Wegner said the gender-inclusive housing option at Stony Brook creates a happy and safe environment, and he feels being happy and healthy plays a big part in being a successful student.

“You’re of value, and you belong here,” he said.

This year the senior is thrilled to be sharing a dorm with his best friend Sydney Monroe Gaglio, who he met early on in college through mutual friends.

“She’s my best friend, and I’m her best friend,” he said. “Just having somebody that I know I can go home to, and [say] this happened, and she’s like ‘I’m sorry.’ She just gets it.”

Ian Rose, who majors in engineering chemistry and applied mathematics and statistics, was thrilled when he heard of the gender-inclusive option. The junior said last year he made friends with Daniel Mahoney, Brandon O’Rourke, Bianca Mugone and Brittany Voboril, and they all became great friends. They lived in the same residence hall — the males in one room on one floor and the girls in their own room on another floor. Many nights last year they would find themselves in each other’s rooms studying or talking and decided to live together.

“We’re friends just hanging out,” Rose said.

This academic year the five are living in a suite with three bedrooms and one bathroom. Rose said at first his only concern was how things would work out in the bathroom, but so far things are going smoothly.

“I just want this to show everyone that guys and girls living together isn’t weird or uncomfortable,” Rose said. “You’re living with your friends; friends are friends. It doesn’t matter if you’re a boy or girl or different skin tone. It doesn’t matter; we’re all the same.”

Ian Rose, right, and friends settle in their three-bedroom suite after a long day. Photo from Ian Rose

Catherine-Mary Rivera, director of residential programs at SBU, said the program began as a small pilot initiative at the university 10 years ago, and grew slowly through the years. In 2016, approximately 40 students took advantage of the housing option, while this year more than 200 students — out of 10,683 living on campus — chose gender-inclusive residences across the campus.

She said the university wants to ensure that all students feel safe and welcome because it’s their home, and they have received plenty of positive feedback regarding the housing.

“The fact that it has grown from 42 to 200 has shown us students feel that they have a place here, and that they don’t have to either feel not comfortable being themselves or feel that Stony Brook doesn’t have a place for them, or they have to remain quiet about who they are or how they express themselves,” Rivera said. “That freedom has come through very clearly that this is a place they can thrive and be their true selves and live with their friends.”

The housing option also allows couples to live together; however, the university does recommend romantic partners think twice before making that decision.

“We want you to branch out and build a stronger community and have healthy relationships, and it may not be best to live with your significant other at this point,” Rivera said.

In addition to gender-inclusive housing, she said SBU offers all-gender, multi-stall bathrooms throughout campus and on the main floors of residence halls, in addition to all-men and all-women restrooms. Software updates have also been made to the school’s system allowing students and faculty members to choose their preferred names and pronoun if they would prefer to be addressed by something other than their legal name. The change means that identification cards and email addresses now show the name a person uses on a regular basis instead of their legal name.

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Alex Orlov on the campus of the University of Cambridge. Photo by Nathan Pitt, University of Cambridge

By Daniel Dunaief

The Ukranian-born Alex Orlov, who is an associate professor of materials science and chemical engineering at Stony Brook University, helps officials in a delicate balancing act.

Orlov, who is a member of the US-EU working group on Risk Assessment of Nanomaterials, helps measure, monitor and understand the hazards associated with nanoparticles, which regulatory bodies then compare to the benefit these particles have in consumer products.

“My research, which is highlighted by the European Union Commission, demonstrated that under certain conditions, [specific] nanoparticles might not be safe,” Orlov said via Skype from Cambridge, England, where he has been a visiting professor for the past four summers. For carbon nanotubes, which are used in products ranging from sports equipment to vehicles and batteries, those conditions include exposure to humidity and sunlight.

“Instead of banning and restricting their production” they can be reformulated to make them safer, he said.

Orlov described how chemical companies are conducting research to enhance the safety of their products. Globally, nanotechnology has become a growing industry, as electronics and drug companies search for ways to benefit from different physical properties that exist on a small scale. Long Island has become a focal point for research in this arena, particularly at the Center for Functional Nanomaterials and the National Synchrotron Light Source II at Brookhaven National Laboratory.

Alex Orlov on the campus of the University of Cambridge. Photo by Nathan Pitt, University of Cambridge

Indeed, Orlov is working at the University of Cambridge to facilitate partnerships between researchers in the chemistry departments of the two universities, while benefiting from the facilities at BNL. “We exchange some new materials between Cambridge and Stony Brook,” he said. “We use BNL to test those materials.”

BNL is an “essential facility,” Orlov said, and is where the postdoctoral student in his lab and the five graduate students spend 30 to 60 percent of their time. The data he and his team collect can help reduce risks related to the release of nanomaterials and create safer products, he suggested.

“Most hazardous materials on Earth can be handled in a safe way,” Orlov said. “Most scientific progress and environmental protection can be merged together. Understanding the environmental impact of new technologies and reducing their risks to the environment should be at the core of scientific and technological progress.”

According to Orlov, the European Union spends more money on technological safety than the United States. European regulations, however, affect American companies, especially those that export products to companies in the European Union.

Orlov has studied how quickly toxic materials might be released in the environment under different conditions.

“What we do in our lab is put numbers” on the amount of a substance released, he said, which informs a more quantitative understanding of the risks posed by a product. Regulators seek a balance between scientific progress and industrial development in the face of uncertainty related to new technologies.

As policy makers consider the economics of regulations, they weigh the estimated cost against that value. For example, if the cost of implementing a water treatment measure is $3 million and the cost of a human life is $7 million, it’s more economical to create a water treatment plan.

Orlov teaches a course in environmental engineering. “These are the types of things I discuss with students,” he said. “For them, it’s eye opening. They are engineers. They don’t deal with economics.”

In his own research, Orlov recently published an article in which he analyzed the potential use of concrete to remove pollutants like sulfur dioxide from the air. While concrete is the biggest material people produce by weight and volume, most of it is wasted when a building gets demolished. “What we discovered,” said Orlov, who published his work in the Journal of Chemical Engineering, “is that if you take this concrete and expose new surfaces, it takes in pollutants again.”

Fotis Sotiropoulos, the dean of the College of Engineering and Applied Sciences at SBU, said Orlov has added to the understanding of the potential benefits of using concrete to remove pollutants.

Other researchers have worked only with carbon dioxide, and there is “incomplete and/or even nonexistent data for other pollutants,” Sotiropoulos explained in an email. Orlov’s research could be helpful for city planners especially for end-of-life building demolition, Sotiropoulous continued. Manufacturers could take concrete from an old, crushed building and pass waste through this concrete in smokestacks.

To be sure, the production of concrete itself is energy intensive and generates pollutants like carbon dioxide and nitrogen dioxide. “It’s not the case that concrete would take as much [pollutants] out of the air as was emitted during production,” Orlov said. On balance, however, recycled concrete could prove useful not only in reducing waste but also in removing pollutants from the air.

Orlov urged an increase in the recycling of concrete, which varies in the amount that’s recycled. He has collaborated on other projects, such as using small amounts of gold to separate water, producing hydrogen that could be used in fuel cells.

“The research showed a promising way to produce clean hydrogen from water,” Sotiropoulos said.

As for his work at Cambridge, Orlov appreciates the value the scientists in the United Kingdom place on their collaboration with their Long Island partners.

“Cambridge faculty from disciplines ranging from archeology to chemistry are aware of the SBU/BNL faculty members and their research,” Orlov said. A resident of Smithtown, Orlov has been on Long Island for eight years. In his spare time, he enjoys hiking and exploring new areas. As for his work, Orlov hopes his work helps regulators make informed decisions that protect consumers while making scientific and technological advances possible.

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Raising the new Stony Brook Southampton Hospital flag at the celebration to introduce Stony Brook Southampton Hospital, from left, Cary F. Staller, Esq., SUNY Board of Trustees and Stony Brook Foundation Board of Trustees; Ambassador Carl Spielvogel, SUNY Board of Trustees; L. Reuven Pasternak, MD, Chief Executive Officer, Stony Brook University Hospital, and Vice President for Health Systems, Stony Brook Medicine; Kenneth Kaushansky, MD, Senior Vice President, Health Sciences, and Dean, Stony Brook University School of Medicine; Robert S. Chaloner, Chief Administrative Officer, Stony Brook Southampton Hospital; Samuel L. Stanley Jr., MD, President, Stony Brook University; Kenneth P. LaValle (R-Port Jefferson), New York State Senator; Kenneth B. Wright, Chair, Southampton Hospital Association Board; Kathy Hochul, New York State Lieutenant Governor; Fred W. Thiele Jr. (I-Southampton), New York State Assemblyman; Fred Weinbaum, MD, Chief Medical Officer and Chief Operating Officer, Stony Brook Southampton Hospital; and Marc Cohen, SUNY Board of Trustees. Photo from SBU

By L. Reuven Pasternak, M.D.

When hospitals in the same region are able to work together, they can deliver health care to residents in ways that are complementary, efficient and effective.

Dr. L. Reuven Pasternak

We are celebrating a major milestone in the development of the Stony Brook Medicine health system to transform health care on the East End of Long Island. On Aug. 1, Stony Brook finalized an agreement with the 125-bed Southampton Hospital — now called Stony Brook Southampton Hospital — to join as a member of Stony Brook Medicine.

Although Stony Brook and Southampton have been providing health care services to the East End for nearly 10 years, this formal agreement will enable us to improve health care quality and access, coordinate care and improve efficiency for patients through shared resources and managing the flow of patients between the two facilities.

Patients will benefit from this relationship because it helps our hospitals match the level of care provided to the level of care needed in the facility ideally suited to a patient’s needs. It provides patients from eastern Long Island with greater access to Stony Brook Medicine’s specialists, clinical trials and advanced technology, combined with the convenience and personalized care of a community-based hospital.

In the time that it has taken to finalize our agreement, we have successfully collaborated on bringing new services to the East End, the most critical of which is the new cardiac catheterization laboratory, part of the Audrey and Martin Gruss Heart & Stroke Center, which will be the first on Long Island to open east of Route 112, and where clinical operations are scheduled to begin on Sept. 5.

An aerial view of Stony Brook Southhampton Hospital. Photo from SBU

And coming in late 2018 is the new Phillips Family Cancer Center, a facility that will be staffed by both Stony Brook-based physicians and physicians from Southampton and promises to make top-level cancer care more easily accessible to East End residents.

Stony Brook and Southampton have been working collaboratively in our hybrid operating room, which is also part of the Audrey and Martin Gruss Heart & Stroke Center. This specialty operating room, equipped with sophisticated imaging, enables Stony Brook board-certified vascular surgeons to perform minimally invasive interventions to treat abdominal aortic aneurysms, complex peripheral arterial disease, carotid disease and the entire spectrum of vascular conditions.

Additional cardiology services have been established in the East End area. Stony Brook cardiologists Travis Bench, M.D., and Dhaval Patel, M.D., have opened practices at 676 County Road 39A, Southampton, and 600 Main Street, Center Moriches, so that patients with specific types of focused cardiac issues can get care closer to home.

Another important benefit of our agreement is that we now have additional clinical training sites to support the growing class sizes of Stony Brook’s undergraduate and graduate medicine training programs, as well as health technology programs. Graduate medical education programs, including internal medicine, family medicine internship and residency programs, plus osteopathic medicine programs in surgery and transitional year resident programs are currently being offered at Stony Brook Southampton Hospital with additional rotations planned for emergency medicine medical students and residents.

Together we are taking a bold step forward for the advancement of health care as we build on our successful collaborations to better serve the needs of Long Islanders.

Dr. L. Reuven Pasternak is the CEO, Stony Brook University Hospital and vice president for health systems, Stony Brook Medicine.

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Steve Kramer raising money to bring Berlinda to U.S. to undergo surgery on her two clubbed feet

By Desirée Keegan

Through the efforts of a retired physicist, an orthopedic surgeon from Stony Brook University and a dedicated Haitian who has since moved to Long Island, a 16-year-old from Haiti is on a path with more open doors than ever.

Berlinda was born with two clubbed feet, though she is motivated to better herself, with the dream of one day walking on her own two feet. Steve Kramer, a retired Brookhaven National Lab accelerator physicist met the student in Haiti through Life & Hope Haiti, a nonprofit founded by Haitian-American Lucia Anglade, who built the Eben Ezer School in her hometown of Milot, Haiti.

Berlinda practices arithmetic. Photo from Steve Kramer

“She had only been at the school for a few months and she was already learning basic arithmetic,” Kramer said of seeing Berlinda back in March, after meeting her during her introduction to the school in December. “I gave her two columns of work and she handed it back to me with a big smile and said, ‘more.’”

Berlinda has spirit, according to many who have met her, and Kramer was so moved by the story that he reached out to Dr. Wesley Carrion at Stony Brook University School of Medicine’s orthopedics department about performing surgery to fix the girl’s feet. He agreed to do it free of charge.

When he contacted Carrion, Kramer said his secretary Joan mentioned he was deployed in Afghanistan and she didn’t know when he would return. Within a day or two she called to tell him she’d heard from the doctor, who said he’d return by April. In May, the two met.

“I sent him copies of Berlinda’s X-rays and the video and he said he felt he could treat her and rotate the feet, and he would donate his time and get the equipment donated,” Kramer said. “That was a big relief. I felt it might become a reality.”

Carrion had informed Kramer that he would need to get the hospital to donate some of the costs, so Kramer reached out to the Department of Medicine’s Dr. L. Reuven Pasternak, who serves as vice president for health systems and chief executive officer of Stony Brook University Hospital.

What the external cages look like that will be used to repair Berlinda’s clubbed feet. Photo from Steve Kramer

“He said they would cover her hospital costs,” Kramer said after his meeting with Pasternak in July. “This was a bigger relief since beside rotating the club feet we need to check out the status of the hole her spinal column might still have from the spinal bifida she was diagnosed as having. Everyone told me the hole doesn’t close up on its own, but she is doing so well that it may have, but it needs to be checked and closed if it is still open.”

To help bring Berlinda to the United States, Kramer set up a GoFundMe to raise money for her flight cost and other post-operation expenses.

“The fundraising has been going slower than I had hoped, even though everyone I contact is verbally supportive,” he said. “As a physicist my human appeal needs a lot of improvement to really move people to give. But then I look at the video and see the determination she has and feel she will deal with it as she has the tragic events she has already endured and I know she will persevere and will learn to walk.”

Following the surgery, Berlinda will be in the hospital for four months, getting her feet rotated to stretch the tendons as part of the healing process. Her legs will be in cages called external frames that will be attached by pins drilled into her leg bones. Because these create open wounds, it’s best for her to stay the hospital instead of returning to Haiti, to keep the wounds sterile. While recovering, she will continue to go through schooling, which will be one-on-one instead of in a larger classroom back in Haiti.

Without the construction of The Eben Ezer School, Berlinda’s struggles might never have come to light for Kramer. What began as a 10-child school back in 2001 has grown to population over 400, according to Anglade.

“I took the $7,000 I received from my tax return and decided I wanted to build a school in my home country — that had been my motivation,” said Anglade, who now lives in West Babylon. “I’m so blessed. I thank God for that, say thank you all the time. It’s a big school now, and we’re still helping.”

Berlinda crawls on her hands and knees because she cannot walk with her two clubbed feet. Photo from Steve Kramer

Anglade first visited Berlinda at her house, and heard from the 16-year-old how her brothers and sisters attended school, and she wished she could join them. Because the school is far from her house, she couldn’t walk there.

“I went to her house and she was quiet, said she can’t go to school,” Anglade said. “I told her I was going to help her, and I took her to the school. I pay someone to stay with her at the school. Her dream is to walk, to learn, to be someone. She wants to be happy.”

Kramer and Stony Brook University Hospital are making her dream a reality.

“Thank God for Steve — he has a good heart and I can’t do it by myself,” Anglade said. “With all my heart, I am so happy. Steve has put in a lot of effort to helping Berlinda make her dream come true.”

Kramer first visited the Eben Ezer School through Wading River’s North Shore United Methodist Church in 2015. He joined a group visiting Haiti in February, and has since visited three more times by himself and with Anglade. They are working toward improving the facilities at the school through solar power and updating the water system.

Kramer also provided economic opportunities for students and natives of the town. He cultivated a group of farmers that grow ancient Egyptian wheat, kumat, which is exported to the U.S.

Now, he’s trying to help provide a future for Berlinda.

“She’s very positive, she’s a sponge for learning,” he said. “I just want to help this Haitian girl who has had a tragic life story so far, but has kept her joy of life and has determination to improve herself.”

Sixteen-year-old Berlinda from Haiti will be receiving surgery on her two clubbed feet at Stony Brook University Hospital. Photo from Steve Kramer

Amy Miller, of Maine, who has helped Anglade since 2007, said she finds what Kramer is doing admirable.

“I met Berlinda and I really respect his desire to help her move forward,” she said. “You meet someone and they kind of capture your heart, and I think you have to follow your heart. That’s what he’s doing.”

Both said they are also moved by Anglade’s motivation.

“I am tremendously inspired by Lucia,” Miller said. “She’s a force. Lucia is a person that astounds most people that meet her — her energy and her commitment. She loves the kids and it’s wonderful to watch. The community once said she should be their mayor after she brought water to the school she also to the community. She’s quite something.”

Anglade said she’s just doing what she thinks is right, in giving back to her hometown.

“My four kids here go to school, they’re in college, they eat every day, but in Haiti, we don’t have enough to feed over 400 kids, so sometimes when we’re down there for a week or two, we can only feed them for one week,” Anglade said. “I can’t go every week, but if I could go every week, every month, I’d go, just to help them. For me to be able to go down there to help those students, my community, I’m so happy to do it. I really feel good about it.”

To donate to help get Berlinda to the United States and to receive the care and post-treatment she will need, visit www.gofundme.com/BerlindasMiracle. To find out more about Life and Hope Haiti, or to get involved, visit www.lifeandhopehaiti.org.

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Tennis players participating in a mixed doubles game in 1967 including Andy Kevey, second from left, and Linwood Lee, right. Photo from Susan Falvey

By Rita J. Egan

The first tournament of the U.S. Open is scheduled for Aug. 28, but Flushing Meadows isn’t the only place in New York filled with tennis history. Since 1959, the Three Village Tennis Club on Main Street in Setauket has provided lifelong memories for its members.

Susan Falvey’s parents, Marta and Andy Kevey, were founding members of the club. She said the women would organize bake sales, fashion shows and dances to raise money, while the men helped maintain the property and the original court. In 1959, yearly dues were $15 for children, $25 for adults and $50 for families.

Marta and Andy Kevey after a tournament at the club in 1967. Photo from Ann Fossan

To her, the spot is a hidden treasure.

“The club is still very active today,” Falvey said. “It’s very simple — we don’t have a clubhouse or anything, but the courts are still in good condition.”

Falvey has fond memories playing as a child at the club and then afterwards riding bikes with friends along Main Street to go to the Jack in the Box near where the Setauket Fire Department firehouse is located today.

In an essay about the club, Andy Kevey wrote of the founding members securing a single tennis court, donated by The Setauket Neighborhood House located behind a barn.

“That old cracked asphalt court went through three metamorphosis each year: tennis court, to basketball court, to ice skating rink,” he wrote. “It had a net for tennis, two baskets for practicing shooting and 6-inch raised borders that allowed it to be flooded in the winter.”

The club hasn’t changed much through the decades, except for the number of courts and who can join. As the population in the area grew in the 1960s, the club limited its membership to residents of the Three Village Central School District.

As the club evolved, six green clay Har-Tru courts were added, and the original asphalt-based court was eventually converted to clay in the 1980s, as water doesn’t drain properly on a harder court. Once the asphalt court was converted to clay, interested players were able to join quicker. Before that, there was a five-year wait.

Wayne Mercer, who joined the club in the late 1980s and has served various positions on the board, remembers due to spacing issues that affected play, court four was moved away from court three and seven away from six. Improvements were also made so the courts would drain better.

“Courts that no one wanted to play on became very playable,” he said.

Current board member Randy Conard’s mother Marion was the first president, and one of the organization’s co-founders. He said the founding of the club was a community effort, where the original board members were trying to expand the popularity of tennis in the area.

Conard said his mother, who died in 2008 at 86, played tennis for decades at the club. His mother’s involvement, he said, “was all for the love of the community and tennis.”

Conard said members would take vacations together, going to resorts and playing tennis. Through the decades, families gathered on the club grounds for barbecues and picnics.

“It was a very tight-knit community,” he said.

Joe McDonnell playing tennis on court two at the club in 1967. Photo from Joe McDonnell

Joe McDonnell moved to Setauket with his family in 1964. A preteen at the time, McDonnell said he could walk to the club by cutting through his neighbor’s backyard. He played at the Three Village Tennis Club for years and as a young man would help maintain the courts. He said his years at the club led to him teaching tennis at Harbor Hills and the Old Field Club during his time in college and graduate school, and in the late 1980s he became a member of the Three Village Tennis Club board.

“It was a club with extraordinary spirit,” McDonnell said. “Like many organizations are when they are first founded, there’s that entrepreneurial spirit.”

McDonnell said he looked up to and learned a great deal about tennis from founding member Bob Pereira, who was also his dentist.

Among the many Stony Brook University professors who were members of the club was Linwood Lee, who still teaches at the college. He said as soon as he found a home in Stony Brook he looked for a tennis club for his family to play at, and enjoyed the camaraderie at the local club.

“It’s been a wonderful place to play tennis and a wonderful place to meet friends,” Lee said.

McDonnell said the club has always helped younger players improve and employed great tennis pros. He recalled Ineke Fisher, who lived in Florida with her husband. During the summers, the couple would come to New York, and Ineke would teach at the Three Village Tennis Club while her husband taught at the Old Field Club. McDonnell said Ineke’s instructions were a mixture of technique and court etiquette.

Once a year the club holds a Wimbledon Woody social event using old wooden rackets like it used to in years past.

“It was a far more finessed game,” McDonnell said, recalling the days he used to only swing a wooden racket. “It was a slower game, but it required you to move a player around a court and not just overpower them.”

Another annual competition at the club is the mixed doubles Van Slyke Tournament. McDonnell said he still remembers Dr. Don Van Slyke, for whom the tournament was named. Van Slyke was a biochemist at Brookhaven National Laboratory, who played well into his 80s.

McDonnell moved to Maine six years ago, but said when he visits Long Island, he makes sure to stop and play at the club. He is considered an honorary member.

“This is a wonderful asset to the community,” he said. “It’s into another generation at this point, but it’s become very much established.”

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Joseph and Maddie Mastriano, co-founders of Three Village Kids Lemonade Stand, held the fifth annual fundraising event at R.C. Murphy Junior High School. Photo by Rita J. Egan

By Rita J. Egan

Thirteen-year-old Joseph and 17-year-old Maddie Mastriano turned lemons into lemonade and then turned a lemonade stand into an annual fundraising event that has raised thousands for Stony Brook Children’s Hospital.

The Three Village Kids Lemonade Stand event was held on the grounds of R.C. Murphy Junior High School in Stony Brook Aug. 2. What started as a simple lemonade stand in front of the Mastrianos’ home one hot day five years ago has turned into a summer event that draws hundreds from the local community to show their support.

Maddie said when she and her brother set up their first lemonade stand, neighborhood children helped them out. They sold lemonade for 50 cents, and at the end of the day, they weren’t sure how to split the few dollars they made amongst 16 kids. Their mother suggested giving the money to a charity, and they decided to donate the money to the children’s hospital since it was in the area.

Volunteers set up the lemonade stand. Photo from Three Village Kids Lemonade Stand

Through the years, the lemonade stand, formerly known as the S-Section Kids Lemonade Stand, began to draw more customers when neighbors discovered through word of mouth that the Mastrianos were donating the money. After serving nearly 500 customers last summer, the family approached the Three Village school district this year to see if the annual event could be held at one of the school’s properties, and the district agreed.

While their first lemonade stand enlisted the help of various neighborhood children, this year’s event included more than 100 volunteers from the school district.

“It’s amazing to know that all those people want to help out with this cause,” Maddie said.

Among the volunteers were the siblings’ cousins Sierra Edwards, 14, Savanna Edwards, 11, and Zoie Mastriano, 11. The girls were helping out at the T-shirt table, and they all said they were amazed at what their relatives had accomplished.

“I don’t know any young kids who have done something like this before,” Zoie said.

At press time, the Mastriano siblings raised more than $19,000 towards their 2017 goal of $20,000. In addition to local residents attending their Aug. 2 event, donations were accepted on their website, and the siblings solicited the help of sponsors. Maddie said they noticed various fundraisers that partnered with companies so she and her brother decided to approach local businesses.

Maddie said it feels good to give back. It’s something she and her brother have learned from her parents who she said are always helping out wherever they can and have been a good influence.

While the event has turned into more than selling lemonade, with corporate sponsors, the Setauket Fire Department on hand giving demonstrations, and the Ward Melville alumni band SWIM performing, the siblings said they enjoy donating their time. Maddie said they think of the children in the hospital who don’t have the chance to enjoy their summer vacation like they do. 

“This is our way of giving back,” Maddie said. “We give them one day of ours to possibly give them summers in the future.”

The Mastriano siblings receiving a proclamation from Brookhaven Supervisor Ed Romaine and Town Clerk Donna Lent. Photo from Three Village Kids Lemonade Stand

The Mastrianos estimated that 400 people stopped by throughout the day including Brookhaven Supervisor Ed Romaine and Town Clerk Donna Lent, presenting them with a proclamation; celebrity chef Barrett Beyer of Hell’s Kitchen, making gourmet lemonade; Mr. Met, greeting guests; and Stony Brook University men’s basketball and women’s soccer teams. Three Village Central School District Superintendent Cheryl Pedisich and board Trustee Inger Germano also stopped by.

County Legislator Kara Hahn (D-Setauket), who grew up in the Three Village school district, has attended the event for the last few years.

“It has been exciting to see it grow and evolve, from block to neighborhood to community event in such a short time,” Hahn said in an email. “This annual event highlights the generosity of spirit within the Three Village community and the compassion of its organizers and volunteers. It is reaffirming to see children and teenagers work so enthusiastically, and with such empathy, to try and ease the suffering of others.” 

Joan Alpers, director of Child Life Services at Stony Brook Children’s Hospital, attended the event and delivered a short speech. She said the funds the children raised will go towards programs such as horticulture therapy, art therapy and music therapy for children plus relaxation sessions for stressed parents.

Alpers said she is amazed by Joseph and Maddie’s work and the community’s support of the children.

“I just think it’s really phenomenal that kids did this one year but then had the resources to do it again and to grow it each year,” Alpers said. “That takes skill, dedication and a special human spirit for a young person.” 

Maddie and Joseph’s father Joseph Mastriano, who was volunteering at the event, said he is proud of his children.

“It teaches them lessons they don’t necessarily learn in school,” the father said. “They went out on their own and solicited different businesses. I think it’s a good experience for them all around.”

Next year’s lemonade stand is scheduled for Aug. 8, 2018 at R.C. Murphy Junior High School. For more information about Three Village Kids Lemonade Stand or to donate, visit www.threevillagekidslemonadestand.com.

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