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Concentrate on lifestyle modifications like going for walks if you want to see potentially disease-modifying effects. Stock photo
Diet and exercise changes may slow progression

By David Dunaief, M.D.

Not surprisingly, osteoarthritis is widespread. The more common joints affected are the knees, hips and hands. There are three types of treatment for this disease: surgery, involving joint replacements of the hips or knees; medications; and nonpharmacologic approaches. The most commonly used first-line medications are acetaminophen and nonsteroidal anti-inflammatory drugs, such as ibuprofen. Unfortunately, medications mostly treat the symptoms of pain and inflammation.

However, the primary objectives in treating osteoarthritis should also include improving quality of life, slowing progression of the disease process and reducing its disabling effects (1).

Dairy and milk

When we think of dairy, specifically milk, there are two distinct camps: One believes in the benefits, and the other thinks it may contribute to the disease. In this case they both may be at least partly correct. In the Osteoarthritis Initiative study, an observational study of over 2,100 patients, results showed that low-fat (1 percent) and nonfat milk may slow the progression of osteoarthritis (2). The researchers looked specifically at joint space narrowing that occurs in those with affected knee joints. Radiographic imaging changes were used at baseline and then to follow the patients for up to 12 to 48 months for changes. Compared to those who did not drink milk, patients who did saw significantly less narrowing of knee joint space.

Was it a dose-dependent response? Not necessarily. Specifically, those who drank less than three glasses/week and those who drank four to six glasses/week both saw slower progression of joint space narrowing of 0.09 mm. Seven to 10 glasses/week resulted in a 0.12 mm preservation. However, those who drank more than 10 glasses/week saw less beneficial effect, 0.06 mm preservation compared to those who did not drink milk. Interestingly, there was no benefit seen in men or with the consumption of cheese or yogurt.

However, there are significant flaws with this study. First, the patients were only asked about their dietary intake of milk at baseline; therefore their consumption could have changed during the study. Second, there was a recall bias; patients were asked to recall their weekly milk consumption for the previous 12 months before the study began. I don’t know about you, but I can’t recall my intake of specific foods for the last week, let alone for the past year. Third, there could have been confounding factors, such as orange consumption.

Oddly, this was not a dose-response curve, since the most milk consumption had less beneficial effect than lower amounts. Also, why were these effects only seen in women? Finally, researchers could not explain why low-fat or nonfat milk had this potential benefit, but cheese was detrimental and yogurt did not show benefit. We are left with more questions than answers.

Would I recommend consuming low-fat or nonfat milk? Not necessarily, but I may not dissuade osteoarthritis patients from drinking it. There are very few approaches that slow the progression of joint space narrowing.

Vitamin D

Over the last five years or so, the medical community has gone from believing that vitamin D was potentially the solution to many diseases to wondering whether, in some cases, low levels were indicative of disease, but repletion was not a change-maker. Well, in a randomized controlled trial (RCT), the gold standard of studies, vitamin D had no beneficial symptom relief nor any disease-modifying effects (3). This two-year study of almost 150 men and women raised blood levels of vitamin D on average to 36 ng/ml, which is considered respectable. Researchers used MRI and X-rays to track their results.

Glucosamine

There is raging debate about whether glucosamine is an effective treatment for osteoarthritis. In the latest installment, there was an RCT, the results of which showed that glucosamine hydrochloride was not effective in treating osteoarthritis (4). In the trial, 201 patients with either mild or moderate knee pain drank diet lemonade with or without 1,500 mg of glucosamine hydrochloride.

There was no difference in cartilage changes in the knee nor in pain relief in those in the placebo or treatment groups over a six-month duration. Bone marrow lesions also did not improve with the glucosamine group. The researchers used 3T MRI scans (an advanced radiologic imaging technique) to follow the patients’ disease progression. This does not mean that glucosamine does not work for some patients. Different formulations, such as glucosamine sulfate, were not used in this study.

Weight

This could not be an article on osteoarthritis if I did not talk about weight. Do you remember analogies from the SATs? Well here is one for you: Weight loss, weight loss, weight loss is to osteoarthritis as location, location, location is to real estate. In a study involving 112 obese patients, there was not only a reduction of knee symptoms in those who lost weight, but there was also disease modification, with reduction in the loss of cartilage volume around the medial tibia (5).

On the other hand, those who gained weight saw the inverse effect. A reduction of tibial cartilage is potentially associated with the need for knee replacement. The relationship was almost one to one; for every 1 percent of weight lost, there was a 1.2 mm³ preservation of medial tibial cartilage volume, while the exact opposite was true with weight gain.

Exercise and diet

In a study, diet and exercise trumped the effects of diet or exercise alone (6). Patients with osteoarthritis of the knee who lost at least 10 percent of their body weight experienced significant improvements in function and a 50 percent reduction in pain, as well as reduction in inflammation, compared to those who lost 5 to 10 percent and those who lost less than 5 percent. This study was a well-designed, randomized controlled single-blinded study with a duration of 18 months.

Researchers used a biomarker — IL6 — to measure inflammation. The diet and exercise group and the diet-only group lost significantly more weight than the exercise-only group, 23.3 and 19.6 pounds versus 4 pounds. The diet portion consisted of a meal replacement shake for breakfast and lunch and then a vegetable-rich, low-fat dinner. Low-calorie meals replaced the shakes after six months. The exercise regimen included one hour of a combination of weight training and walking with alacrity three times per week.

Therefore, concentrate on lifestyle modifications if you want to see potentially disease-modifying effects. These include both exercise and diet. In terms of low-fat or nonfat milk, while the study had numerous flaws, if you drink milk, you might continue for the sake of osteoarthritis, but stay on the low end of consumption. And remember, the best potential effects shown are with weight loss and with a vegetable-rich diet.

References:

(1) uptodate.com. (2) Arthritis Care Res online. 2014 April 6. (3) JAMA. 2013;309:155-162. (4) Arthritis Rheum online. 2014 March 10. (5) Ann Rheum Dis online. 2014 Feb. 11. (6) JAMA. 2013;310:1263-1273.

Dr. Dunaief is a speaker, author and local lifestyle medicine physician focusing on the integration of medicine, nutrition, fitness and stress management. For further information, visit www.medicalcompassmd.com or consult your personal physician.

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Robert Verbeck donates platelets to Stony Brook University Hospital almost once a month. Photo from Cassandra Huneke

Because so many are in need of life-saving blood cells, a local teacher is doing all he can to help a hospital’s supply match its demand.

Almost once a month for the past few years, Miller Avenue Elementary School fifth-grade teacher Robert Verbeck has traveled to Stony Brook University Hospital to donate his platelets. Last Thursday marked his 114th time.

Though not quite squeamish, Verbeck said he feels almost wrong for talking about it, saying he doesn’t see much nobility in sacrificing a small amount of time to help save lives.

“It might feel self-aggrandizing if I say I’m out there saving people’s lives every couple of weeks, but people can die when they don’t have enough platelets.”

— Robert Verbeck

“I almost feel guilty, though at the same time, you know you’re saving somebody’s life,”the Shoreham-Wading River school district teacher said. “It might feel self-aggrandizing if I say I’m out there saving people’s lives every couple of weeks, but people can die when they don’t have enough platelets.”

Verbeck’s stepfather and retired NYPD officer John Eaton had also been a prolific platelet donor before he passed away in May 2008. Eaton donated approximately 24 times a year, close to the maximum a person can donate in 12 months, according to Verbeck.

“He just wanted to help people — that’s why he became a cop in the first place,” Verbeck said. “He just kind of kept donating. In a weird way, I don’t want to say it’s addictive, but you get a really good feeling from doing it. You keep coming back.”

Platelets, tiny cells in the blood that form clots and stop bleeding, are essential to surviving and fighting cancer, chronic diseases and traumatic injuries. Every 30 seconds a patient is in need of platelets and more than 1 million platelet transfusions are given to patients each year in the U.S. Once a donation is given, the platelets must be used within five days.

“Stony Brook University Hospital never has enough donated platelets to satisfy our demand, therefore, we have to purchase the from other larger blood products facilities,”  said Linda Pugliese, a blood bank recruiter at Stony Brook. She said most of the hospital’s platelets are purchased from Red Cross. Over 10 years, Eaton donated more than 100 times, according to Pugliese.

“I understand people have their lives, they have their problems and not everyone can sacrifice their time, but If everybody donated a few times a year, we wouldn’t be so tight.”

— Dennis Galanakis

“Without them we couldn’t function,” said Dr. Dennis Galanakis, director of transfusion medicine at Stony Brook Hospital. “The problem with platelets is they have to be stored in a special way. They have to have all the tests that are required for safety. They only have a five-day shelf life, and it takes two days to do all the tests, so in practice, the shelf life is about three days.”

Verbeck was an efficient blood donator before he heard about platelets, and while at first he said he was skeptical, that changed when a friend of his was diagnosed with cancer.

“I started doing it, and just like my dad, I felt it was a good thing to do,” he said. “I was doing it five or six times a year. After my dad died, it was a loss, and not just my personal loss, but it was a loss with their supply — it was one less person donating. So that gave me the impetus.”

The entire platelet donation process takes about two hours. Machines take half cup of blood through one vein and processes it to remove platelets before returning the blood through another vein.

April is National Donate Life Month, so to join Verbeck in his quest to feed the blood banks, potential givers can call Stony Brook Hospital at 631-444-3662 or find out more online at stonybrookmedecine.edu and to schedule an appointment.

“Only a small number of people donate at any given time,” Galanakis said. “I understand people have their lives, they have their problems and not everyone can sacrifice their time, but If everybody donated a few times a year, we wouldn’t be so tight.”

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Attention all veterans and their caregivers:
Operation-Initiative Foundation will present a Holistic Healing Workshop for Veterans with PTSD and Mild Traumatic Brain Injury at Trinity Evangelical Lutheran Church, 716 Route 25A, Rocky Point on Saturday, April 14 from 9 a.m. to 4 p.m. This event will feature speakers that will address the advances made in their respective disciplines and in Complementary and Alternative Medicine that are at the forefront in treating veterans who have been diagnosed as having PTSD. Additional discussion will focus on supportive needs of their family caregivers. All veterans and caregivers should bring a copy of their DD 214. All information is kept completely confidential. Seating is limited and lunch will be provided. To reserve your spot, call 631-744-9355.
The mission of the Operation-Initiative Foundation is to bring awareness, information and support to veterans and their caregivers who are suffering from Post-Traumatic Stress.

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On Tuesday, April 10, Harbor Country Day School will host a community forum, titled “Addictive Behaviors in Adolescents and Adults: Warning Signs, Risky Behaviors and Helpful Resources.” The forum will feature mental health, medical, and social services experts, who will lead attendees in a candid discussion about various forms of addiction, including technology and video game addiction, social media dependence, alcohol and other substance abuse, vaping and “gateway drugs,” and opioid addiction.

WHAT:   “Addictive Behaviors in Adolescents and Adults: Warning Signs, Risky Behaviors and Helpful Resources”

Panelists will include:

  • Kym Laube, Executive Director of Human Understanding and Growth Services, Inc. (HUGS)
  • Linda Ventura, Founder of Thomas’ Hope Foundation
  • Noam Fast, M.D., Medical Director of the Mather Hospital Chemical Dependency Clinic
  • Jason Bleecher, Licensed Master Social Worker & Substance Abuse Therapist
  • Carissa Millet, Licensed Clinical Social Worker

WHEN:      Tuesday, April 10, 7:00 p.m.-9:00 p.m.

WHERE:     Harbor Country Day School

17 Three Sisters Road

St. James, NY 11780

HOW:   Free tickets are available at https://hcds.eventbrite.com or by calling (631) 584-5555

WHY:   As today’s adolescents and their parents and caregivers face growing societal and personal challenges, addictive behaviors are appearing in many new forms and to extreme degrees. The forum will provide an opportunity for a candid discussion about the prevalence of these addictions, warning signs to be aware of, and solutions and community resources for those in need.

 

About Harbor Country Day School

Founded in 1958 by conscientious parents, Harbor Country Day School is an independent, co-educational day school for children from preschool through eighth grade in St. James. Emphasizing a whole-child approach to education, Harbor offers a rigorous curriculum enhanced by signature programs in STEAM, global languages, math, and language arts, with a strong emphasis on character development. The school’s mission to “cherish childhood, cultivate wonder, and inspire confident learners and leaders” underscores every student’s experience and ensures that all of its graduates are prepared to lead fulfilling lives filled with wonder, confidence, and many successes. Harbor Country Day School’s summer camp program, Camp Harbor, is among the leading summer camp programs on Long Island.

Harbor Country Day School is chartered by the New York State Board of Regents and is accredited by and a member of the New York State Association of Independent Schools (NYSAIS).  It is a non-sectarian, nonprofit organization under section 501(c) (3) of the IRS Code governed by a self-perpetuating board of trustees.  For more information, visit www.hcdsny.org.

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The Ammerman campus of Suffolk County Community College, 533 College Road, Selden will hold its 30th annual Health Fair in the Babylon Student Center on Wednesday, April 4, from 10 a.m. to 1 p.m. Visit the many SCCC resource tables including Nursing, Paramedic/EMT and Dietetic Technician, along with more than 30 vendors offering free healthy snacks, raffles, giveaways, Reiki, massages, health screenings including: carbon monoxide, body fat to muscle ratio, cholesterol, blood pressure and STD and HIV testing, and much more. Open to the public. Free admission. Questions? Call 451-4047.

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Berlinda crawling before Dr. Wesley Carrion performed surgery on her two clubbed feet at Stony Brook University Hospital. Photo from Steve Kramer

A teen born with two clubbed feet is closer to her dream of walking on her own thanks to the efforts of Long Islanders and Stony Brook University Hospital.

When Steve Kramer, a retired Brookhaven National Laboratory accelerator physicist, traveled to Haiti last year through Life & Hope Haiti, a nonprofit founded by Haitian-American Lucia Anglade, he never knew what a profound impact his trip would have on one student’s life. It was while working at the Eben-Ezer School, built by Anglade in Milot, Haiti, he met 16-year-old Berlinda, who would crawl to get from one spot to another.

Berlinda with Steve Kramer, behind wheelchair, Lucia Anglade, left, and Dr. Wesley Carrion, after her surgery. Photo from Steve Kramer

Moved by her struggles, Kramer reached out to Dr. Wesley Carrion at Stony Brook University School of Medicine’s Department of Orthopaedics about performing surgery to fix Berlinda’s feet. Kramer sent the doctor copies of her X-rays, and Carrion told him he felt he could treat her and rotate the feet. He agreed to do it free of charge, donating his time and equipment.

“We looked at her and felt she had a fairly good chance of standing,” Carrion said.

After Carrion performed surgery on Berlinda in November, fixators — external frames that are attached by pins drilled into leg bones -— were used to rotate her feet to stretch the tendons. After the fixators were in place, Berlinda received outpatient services from the hospital, and she stayed at Anglade’s home on Long Island, according to Kramer.

The fixators were removed March 9 and Berlinda was put in leg casts until March 19. She has been working with physical therapists at the hospital, and while she can stand with braces with help, she has a long way to go before she can stand on her own.

“She was crawling around her village. She was unable to stand, so when we got her up with physical therapy, those were literally her first steps.”

— Dr. Wesley Carrion

Kramer said she has to build up strength, and she feels a lot of pain when she moves her left knee as it is locking up after not being used for months. However, he said she was pleased to be out of the fixators, which caused her pain at times.

Carrion said fixators can be painful, and when Berlinda’s wheelchair would hit bumps, the pain would increase.

“It’s tough when you got these fixator frames on that look like giant tinker toys that you attach to the limbs,” Carrion said. “They’re things that hurt. They’re things that are uncomfortable.”

Carrion said it’s difficult to determine if Berlinda will stand without braces. She had polio and did not receive proper treatment, and also has spina bifida. Carrion said despite a hole in her spinal column, it hasn’t presented any problems.

“If we can get her walking with braces, that’s a huge win,” Carrion said. “She was basically crawling around her village. She was unable to stand, so when we got her up with physical therapy, those were literally her first steps.”

Kramer said the hope is for Berlinda to stay until she completes physical therapy, which will take a few months, since she will receive better treatment in Stony Brook than in Haiti. To help with Berlinda’s airfare and outpatient expenses, Kramer set up a GoFundMe page.

Berlinda and the temporary casts she wore before getting leg braces. Photo from Steve Kramer

He said with money from that account, he can buy physical therapy equipment, like parallel bars so she can practice standing and walking outside of physical therapy treatments.

Kramer said during Berlinda’s stay in New York, it was the first time she saw snow, and he showed her how to make a snowball.

“She knew what to do with it,” Kramer said. “She wanted to throw it at me, and she did.”

Kramer said Berlinda, who will turn 17 April 13, loves learning, and despite attending school for only one year, easily solved basic arithmetic problems when he first met her.

“She never lost that bright smile and willingness to work with whatever she had,” Kramer said, adding that sometimes those with handicaps in her village are shunned and even her siblings have bullied her.

When Kramer first approached Carrion, the doctor informed him that he would also need to get the hospital to donate some of the costs for the November surgery. It was then Kramer reached out to Department of Medicine’s Dr. L. Reuven Pasternak, who serves as vice president for health systems and chief executive officer of Stony Brook University Hospital. Pasternak said requests like Kramer’s to waive charges are not unusual from doctors and members of the community.

“She never lost that bright smile and willingness to work with whatever she had.”

— Steve Kramer

“We do this from time to time, and the way it usually occurs is that a physician encounters somebody, oftentimes overseas, and in the course of doing a medical mission or in their travels,” Pasternak said. “And it’s somebody who has a correctable medical condition that will make a huge impact on their lives.”

While Pasternak was out of town during the surgery and hasn’t met Berlinda yet, he said Kramer and Carrion have kept him informed about her recovery and follow-up treatment.

“It’s a testimony to cooperation and collaboration because it required a lot of people to step up and say that this is important to do and basically volunteer to do it,” he said.

For more information about fundraising efforts to help Berilnda, visit www.gofundme.com/berlindasmiracle. To find out more about Life & Hope Haiti or to get involved, visit www.lifeandhopehaiti.org.

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Season allergies are triggered by pollen from trees, grass and weeds. Stock photo

By David Dunaief, M.D.

Dr. David Dunaief

After winter ends, we look forward to mild temperatures. The days get longer, trees and flowers bud and bloom, and grass becomes lush and green. It seems like heaven. But for people who suffer from seasonal allergic rhinitis, hay fever, seasonal allergies or whatever you would like to call it, life can be downright miserable. You probably can rate an allergy season with your own built-in personal barometer, the sneeze factor. How many times are you, your friends or your colleagues sneezing?

Approximately 20 million U.S. adults have had a diagnosis of seasonal allergies within the past year, just a little over 8 percent of the population, and an additional 6.1 million children have this disorder, or about 8.4 percent, according to the Centers for Disease Control and Prevention (1). Sadly, considering the number of people it affects, only a paltry amount of research has been published.

The triggers for seasonal allergies are diverse. They include pollen from leafy trees and shrubs, lush grass and beautiful flowering plants, as well as weeds, with the majority from ragweed (mostly in the fall) and fungus (summer and fall) (2).

What sparks allergies within the body? A chain reaction occurs in seasonal allergy sufferers. When foreign substances such as allergens (pollen, in this case) interact with immunoglobulin E (IgE), antibodies that are part of our immune system, it causes mast cells in the body’s tissues to degrade and release inflammatory mediators. These include histamines, leukotrienes and eosinophils in those who are susceptible. In other words, it is an allergic inflammatory response.

The revved up immune system then responds with sneezing; red, itchy and watery eyes; scratchy throat; congestion; sinus headaches; postnasal drip; runny nose; diminished taste and smell; and even coughing (3). Basically, it emulates a cold, but without the virus. If symptoms last more than 10 days and are recurrent, then it is more than likely you have allergies.

Risk factors for seasonal allergies are tied most strongly to family history and to having other personal allergies, such as eczema or food allergies, but also may include cigarette exposure, being male and, possibly, diet (4). If allergic rhinitis is not properly treated, complications such as ear infections, sinusitis, irritated throat, insomnia, chronic fatigue, headaches and even asthma can result (5).

To treat allergic rhinitis, we have a host of medications from classes including intranasal glucocorticoids (steroids), oral antihistamines, allergy shots, decongestants, antihistamine and decongestant eye drops and leukotriene modifiers (second-line only).

The best way to treat allergy attacks is to prevent them, but this is an arduous process that can mean closing yourself out from the enjoyment of spring by literally closing the windows, using the air-conditioning, and using recycling vents in your car.

The guidelines for treating seasonal allergic rhinitis with medications suggest that intranasal corticosteroids (steroids) should be used when quality of life is affected. If there is itchiness and sneezing, then second-generation oral antihistamines may be appropriate (6). Two well-known inhaled steroids that do not require a prescription are Nasocort (triamcinolone) and Flonase (fluticasone propionate). There does not seem to be a significant difference between them (7). While inhaled steroids are probably most effective in treating and preventing symptoms, they need to be used every day and are not without side effects.

Oral antihistamines, on the other hand, can be taken on an as-needed basis. Second-generation antihistamines include loratadine (Claritin), cetirizine (Zyrtec) and fexofenadine (Allegra), and they have less sleepiness as a side effect than first-generation antihistamines.

Surprisingly good news

Seasonal allergic rhinitis may actually be beneficial for longevity. In a study involving more than 200,000 participants, results showed that those who had allergies had a 25 percent reduction in the risk of heart attacks, a 19 percent reduction in strokes, and a whopping 49 percent reduction in mortality (8). Remember two things: this is an observational trial, which means that it is not the best of trials, and don’t wish allergies on yourself. This effect may be at least partially attributable to the type of white blood cell expressed in the immune system.

In other words, type 2 T helper (Th2) lymphocytes (white blood cells) are elevated with allergies instead of type 1 T helper (Th1) lymphocytes. Why is this important? Th2 is known to decrease cardiovascular disease, while Th1 is known to possibly increase cardiovascular disease. Unfortunately, the same cannot be said about asthma, where cardiovascular events are increased by 36 percent.

Alternative treatments

Butterbur (Petasites hybridus), an herb, may not be just for migraines. There are several small studies that indicate its efficacy in treating hay fever. In fact, in one study, results showed that butterbur was as effective as cetirizine (Zyrtec) in treating this disorder (9). This was a small, randomized, controlled trial involving 131 patients.

In another randomized, controlled trial, results showed that high doses of butterbur — 1 tablet given three times a day — was significantly more effective than placebo (10). The side effects were similar in the placebo group and the butterbur group. The researchers used butterbur Ze339 (carbon dioxide extract from the leaves of Petasites hybridus L., 8 mg petasines per tablet) in the trial. The authors concluded that butterbur would be potentially useful for intermittent allergic rhinitis. The duration of treatment for this study was two weeks.

Still another study, this one a post-marketing study done as a follow-up to the previous study, showed that with butterbur Ze339, symptoms improved in 90 percent of patients with allergic rhinitis (11). Interestingly, anti-allergic medications were co-administered in about half of the patient population, with no additional benefit over butterbur alone. There were 580 patients in this study, and the duration was two weeks. Gastrointestinal upset occurred as the most common side effect in 3.8 percent of the population.

The caveats to the use of butterbur are several. First, the studies were short in duration. Second, the leaf extract used in these studies was free of pyrrolizidine alkaloids (PAs); this is very important since PAs may not be safe. Third, the dose was well-measured, which may not be the case with over-the-counter extracts. Fourth, you need to ask about interactions with your prescription medications.

Diet

While there are no significant studies on diet, there is one review of literature that suggests that a plant-based diet may reduce symptoms of allergies, specifically rhinoconjunctivitis, affecting the nose and eyes, as well as eczema and asthma. This is according to the International Study of Asthma and Allergies in Childhood study in 13- to 14-year-old teens (12). In my clinical practice, I have seen patients who suffer from seasonal allergies improve and even reverse the course of allergies over time with a vegetable-rich, plant-based diet, possibly due to an anti-inflammatory effect.

While allergies can be miserable, there are a significant number of over-the-counter and prescription options to help to reduce symptoms. Diet may play a role in the disease process by reducing inflammation, though there are no formal studies. There does seem to be promise with some herbs, especially butterbur. However, alternative supplements and herbs lack large, randomized clinical trials with long durations. Always consult your doctor before starting any supplements, herbs or over-the-counter medications.

References: (1) CDC.gov. (2) acaai.org/allergies/types/pollen-allergy. (3) Allergy Clin Immunol. 2003;112(6):1021-1031. (4) umm.edu. (5) J Allergy Clin Immunol. 2010;125(1):16-29. (6) Otolaryngol Head Neck Surg. online February 2, 2015. (7) Otolaryngol Head Neck Surg. 2003;129(1):16. (8) AAAAI 2014: Abstract 811. (9) BMJ 2002;324:144. (10) Arch Otolaryngol Head Neck Surg. 2004;130(12):1381-1386. (11) Adv Ther. 2006;23(2):373-384. (12) Eur Respir J. 2001;17(3):436-443.

Dr. Dunaief is a speaker, author and local lifestyle medicine physician focusing on the integration of medicine, nutrition, fitness and stress management. For further information, visit www.medicalcompassmd.com or consult your personal physician.

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Symptoms of gallstones include dull or crampy abdominal pain that is exacerbated by meals and lasts one to five hours. Stock photo

By David Dunaief, M.D.

Dr. David Dunaief

Gallstones are a very common gastrointestinal disease; they affect up to 20 million Americans between the ages of 20 and 74, with a more than two-times increased occurrence in women than in men, according to the NHANES III survey (1). There are two types of gallstones, 80 percent of which are cholesterol stones and 20 percent of which are pigment stones.

Common symptoms

Gallstones may be asymptomatic; however, when gallstones block either the cystic or common bile ducts, symptoms occur. Symptoms include dull or crampy abdominal pain that is exacerbated by meals and lasts one to five hours. Jaundice, which includes yellowing of skin and eyes, is another symptom. Others include nausea and vomiting, rapid heart rate, hypotension (low blood pressure) and fever (2).

Tests used for diagnosis

Blood tests include complete blood count, where there may be a rise in white blood cells; liver enzymes; and the pancreatic enzymes lipase and amylase. In general, diagnostic tests that have more accuracy are the endoscopic ultrasonography (EUS) and endoscopic retrograde cholangiopancreatography (ERCP). However, these are invasive tests. Less accurate but noninvasive tests include abdominal X-ray, ultrasound and CAT scan (CT). The tests used also depend on where the stone may be located. Hepatobiliary (HIDA) scans are accurate if the stone is located in the cystic duct. And magnetic resonance retrograde cholangiopancreatography (MRCP) is used if the stone is thought to be located in the common bile duct (2).

What are the risk factors?

There are a multitude of risk factors. Some of these are modifiable, some others are not. The modifiable ones include obesity, measured by body mass index (BMI); rapid weight loss; fat consumption; hormone replacement therapy (HRT); oral contraceptives; decreased physical activity; Crohn’s disease; and certain drugs. One nonmodifiable risk factor is age; the older we get, the higher the risk, with age 40 being the demarcation line (3). Other risk factors are gender, with females being more predisposed; pregnancy; and family history (4). Let’s look at the evidence.

Obesity risks

Obesity may play an important role. Obesity is not age discriminant; it can impact both adults and children. The reason obesity is implicated is potentially due to bile becoming supersaturated (5). Bile is a substance produced in the liver and stored in the gallbladder. Bile aids in the digestion or breakdown of fats in the small intestines. Crystals may form, creating cholesterol gallstones from the bile.

Body mass index

A body mass index of greater than 30 kg/m² is considered obese. In a meta-analysis of two prospective, forward-looking observational trials, Copenhagen General Population Study and the Copenhagen City Heart Study, those in the highest quintile of BMI were almost three times as likely to experience symptomatic gallstones compared to those who were in the lowest quintile (6). The highest quintile was those who had a mean BMI of 32.5 kg/m² and thus were obese, whereas those in the lowest quintile had a mean BMI of 20.9 kg/m². This is a comparison of ideal to obese BMI. Not surprisingly, since women in general have a higher risk of gallstones, they also have a higher risk when their BMI is in the obese range compared to men, a 3.36-fold increase and 1.51-fold increase, respectively.

Also, the research showed that for every 1 kg/m² increase in BMI, there was a 7 percent increase in the risk of gallstones. Those who had genetic variants that increased their likelihood of an elevated BMI had an even greater increase in gallstone risk —17 percent — per 1 kg/m². In the study population of approximately 77,000, more than 4,000 participants became symptomatic for gallstones.

Gallstones in children

Sadly, obese children are not immune to gallstones, even though they are young. In a prospective observational study based on Kaiser Permanente data from southern California, children who were overweight had a twofold increased risk of gallstones (7). But if that is not enough, girls who were extremely obese had a higher propensity for gallstones, similar to women in the previous study, with a greater-than-sevenfold increase compared to a still very substantial greater-than-threefold increase for obese boys. Hispanic children were affected the most. The age range in this study was between 10 and 19 years old. Obesity is a disease that is blind to age.

Physical activity

We know physical activity is very important to stave off many diseases, but in this case, the lack of physical activity can be detrimental. In the Physicians’ Health Study, a prospective observational trial, those in the lowest quintile of activity between the ages of 40 and 64 had a 72 percent increased risk of gallstone formation, and those 65 and older had a 33 percent increased risk (8). Also, men who were 65 and older and watched television more than six hours a week were at least three times as likely to have gallstones as those who watched fewer hours. There was a substantial increased risk for those under 65, as well, though to a slightly lesser degree.

Diabetes rears its ugly head

Just like with obesity, diabetes is almost always a culprit for complications. In a prospective observational study, those with diabetes were at a significant 2.55-times greater risk of developing gallstones than those without (9). Again, women had a higher propensity than men, but both had significant increases in the risk of gallstone formation, 3.85-times and 2.03-times, respectively. There were almost 700 participants in this study. The researchers believe that an alteration in glucose (sugar) metabolism may create this disease risk.

Hormone replacement therapy

If you needed another reason to be leery of hormone replacement therapy (HRT), then gallstones might be it. In a prospective observational trial, women who used HRT, compared to those who did not, had a 10 percent increased risk in cholecystectomy — removal of the gallbladder — to treat gallstones (10). Though this may not sound like a large increase, oral HRT increased the risk 16 percent, and oral estrogen-only therapy without progestogens increased the risk the most, 38 percent. Transdermal HRT did not have a significantly increased risk.

It is never too early or too late to treat obesity before it causes, in this case, gallstones. With a lack of exercise, obesity is exacerbated and, not surprisingly, so is symptomatic gallstone formation. Diabetes needs to be controlled to prevent complications. HRT, unless menopausal symptoms are unbearable, continues to show why it may not be a good choice. Next week, we will look at the complications of gallstones and how to prevent them.

References: (1) Gastroenterology. 1999;117:632. (2) emedicine.medscape.com. (3) J Hepatol. 1993;18 Suppl 1:S43. (4) uptodate.com. (5) Best Pract Res Clin Gastroenterol. 2014 Aug;28:623-635. (6) Hepatology. 2013 Dec;58:2133-2141. (7) J Pediatr Gastroenterol Nutr. 2012;55:328-333. (8) Ann Intern Med. 1998;128:417. (9) Hepatology. 1997;2:787. (10) CMAJ. 2013;16;185:549-550.

Dr. Dunaief is a speaker, author and local lifestyle medicine physician focusing on the integration of medicine, nutrition, fitness and stress management. For further information, visit www.medicalcompassmd.com or consult your personal physician.

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A plant-based diet involving lots of vegetables, fruits and some grains may have a similar effect as steroids in reducing inflammation. Stock photo
Steroids reduce inflammation, but it comes at a cost

By David Dunaief, M.D.

Dr. David Dunaief

Steroid use as a performance-enhancing drug was a significant factor in the recent Olympics, with the Russian team banned for their illegal use. However, if we look beyond the flashy headlines to rudimentary use, we see that corticosteroids, or steroids, play an important role in medicine.

This is a commonly prescribed class of medications. In fact, our bodies make corticosteroids, the indigenous form of steroids, in the cortex of the adrenals, glands that sit on top of the kidneys. Here, we are going to concentrate on the exogenous form, meaning from the outside as medication.

Use or benefit

Steroids have an anti-inflammatory effect. This is critical since many acute and chronic diseases are based at least partially on inflammation. Chronic diseases that benefit include allergic, inflammatory and immunological diseases (1). These types of diseases touch on almost every area of the body from osteoarthritis and autoimmune diseases — rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, lupus, psoriasis and eczema — to asthma, COPD (emphysema and chronic bronchitis) and eye disorders. This type of medication is pervasive.

Delivery

Steroids are delivered orally, topically as creams, lotions and eye drops, or via injections, intravenous solutions and inhaled formulations. The most commonly known medication is prednisone, but there is a plethora of others, including prednisolone, methylprednisolone, cortisone, hydrocortisone and dexamethasone. Their benefits can be tremendous, improving functionality and reducing pain or improving breathing. You could say they are lifesaving in some instances, and with rescue inhalers they may just be that.

The bad

However, there is a very big caveat: they come at a price. Steroids have lots of adverse events associated with them. This is where the bad part comes in and keeps on coming. Steroids cause weight gain, increased glucose (sugars), high blood pressure, cardiovascular events, osteoporosis, change in mood (psychoses), cataracts, glaucoma, infection, peptic ulcers, Cushing’s syndrome and the list goes on. Ironically, steroids help with breathing; however, as I’ve seen in my clinical experience, they can cause shortness of breath when weaned from a longer-use high dose too quickly.

The upshot

The good news is that a plant-based diet may have similar beneficial effects in chronic diseases as steroids without all the downsides. Let’s look at the evidence.

The role in pneumonia

Pneumonia is among the top-10 leading causes of death in the world (2). It can be a most painful and debilitating disease. I know, for I experienced it personally while I was in my medical training. Every time I coughed, it felt like there was a fire in my chest.

In a meta-analysis (a group of nine studies), there was no overall effect of corticosteroids in reducing the risk of mortality in community-acquired pneumonia (3). However, don’t fret; when the data was broken into subsets, the findings were different. In subset data of those who had severe pneumonia, there was a statistically significant 74 percent reduction in mortality. And when duration was the main focus in subgroup analysis, those who received prolonged use of steroids reduced their risk of mortality by half.

Unfortunately, with the benefit comes an increased risk of adverse events, and this meta-analysis was no exception. There was a greater than two-times increased risk of abnormally high glucose levels with prolonged use. Thus, when giving steroids, especially for a prolonged use, it may be wise to check glucose levels.

In a more recent randomized controlled trial (RCT), the gold standard of studies, the results reinforced the beneficial effects of steroids on pneumonia. They showed that in those with both severe pneumonia and high inflammation, there was a two-thirds reduction in treatment failures when corticosteroids were added to the regimen (4). There were 120 patients involved in the study. They received antibiotics plus either methylprednisolone or placebo for five days.

Osteoarthritis: surprising results

As we know, osteoarthritis specifically of the knee is very common, especially as the population continues to age. Intra-articular (in the joint) injections directly into the knee are becoming routine treatment. A recent study compared injectable hyaluronic acid to injectable corticosteroid (5). The results showed that over three months, the corticosteroid was superior to hyaluronic acid in terms of reducing pain, 66 percent versus 43.8 percent, respectively. Interestingly, over the longer term, 12 months, hyaluronic acid reduced the pain and maintained its effect significantly longer than the steroid, 33 percent versus a meager 8.2 percent, respectively.

Study groups received five injections of either steroid or of hyaluronic acid directly to the knee over a five-week period. Thus, steroids may not always be the most effective choice when it comes to pain reduction. Hyaluronic acid may have caused this beneficial effect by reducing inflammation, protecting cartilage and preventing cell death, according to the authors.

COPD: length may not matter

It is not unusual to treat COPD patients with oral steroids. But what is the proper duration? The treatment paradigm has been two weeks with 40 mg of corticosteroids daily. However, results in an RCT showed that five days with 40 mg of corticosteroid was noninferior (equivalent) to 14 days of the same dosage and frequency (6). About one-third of patients in each group experienced a COPD exacerbation within the six-month duration of the trial. The hope is that the shorter use of steroids will mean fewer side effects. There were over 600 patients in this trial. We have come a long way; prior to 1999, eight weeks of steroids was a more commonplace approach to treating acute COPD exacerbations.

Topical steroid risk

Even topical creams and lotions are not immune to risk. For example, potent topical creams and lotions placed around the orbit of the eye with prolonged use may negatively affect vision (7). However, the evidence is based mostly on case reporting, which is a low level of evidence.

Dietary effect

One of the great things about steroids is that they reduce inflammation, and we know that the basis of greater than 80 percent of chronic disease is inflammation. A plant-based diet involving lots of vegetables, fruits and some grains may have a similar effect as steroids. The effect of diet on chronic disease may be to modify the immune system and reduce inflammation (8).

The bioactive substances from plants thought to be involved in this process are predominantly the carotenoids and the flavonoids. Thus, those patients who respond even minimally to steroids are likely to respond to a plant-based diet in much the same beneficial way without the downsides of a significant number of side effects. Diet, unlike steroids, can be used for a long duration and a high intake, with a direct relationship to improving disease outcomes.

In conclusion, it is always better to treat with the lowest effective dose for the shortest effective period when it comes to steroids. The complications of these drugs are enumerable and must always be weighed against the benefits. Sometimes, other drugs may have more beneficial effects over the long term, such as hyaluronic acid injections for knee osteoarthritis. A plant-based diet, with anti-inflammatory properties similar to steroids, may be a useful alternative for chronic disease or may be used alongside these drugs, possibly reducing their dosage and duration.

References: (1) uptodate.com.(2) N Engl J Med. 1995;333(24):1618-24. (3) PLoS One. 2012;7(10):e47926. (4) JAMA. 2015;313(7):677-686. (5) Open Access Rheum 2015;7:9-18. (6) JAMA. 2013;309(21):2223-31. (7) Australas J Dermatol. Mar 5, 2015. (8) Int J Vitam Nutr Res. 2008 Dec;78(6):293-8.

Dr. Dunaief is a speaker, author and local lifestyle medicine physician focusing on the integration of medicine, nutrition, fitness and stress management.

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If there were ever a reason needed for obese patients to lose weight, treating atrial fibrillation should be on the top of the list. Stock photo
Medications treat rate or rhythm or prevent strokes

By David Dunaief, M.D

Dr. David Dunaief

Atrial fibrillation is the most common arrhythmia, an abnormal or irregular heartbeat, found in the U.S. Unfortunately, it can be very complicated to treat. Though there are several options, including medications and invasive procedures, it mostly boils down to symptomatic treatment rather than treating or reversing underlying causes.

What is AFib? It is an electrical malfunction that affects the atria, the two upper chambers of the heart, causing them to beat “irregularly irregular.” This means there is no set pattern that affects the rhythm and potentially causes a rapid heart rate. The result of this may be insufficient blood supply throughout the body.

Complications that may occur can be severely debilitating, such as stroke or even death. AFib’s prevalence is expected to more than double by 2030 (1). Risk factors include age (the older we get, the higher the probability), obesity, high blood pressure, premature atrial contractions and diabetes.

AFib is not always symptomatic; however, when it is, symptoms include shortness of breath, chest discomfort, light-headedness, fatigue and confusion. This arrhythmia can be diagnosed by electrocardiogram, but more likely with a 24-hour Holter monitor. The difficulty in diagnosing AFib sometimes is that it can be intermittent.

There may be a better way to diagnose AFib. In a study, the Zio patch, worn for 14 days, was more likely to show arrhythmia than a 24-hour Holter monitor (2). The Zio patch is a waterproof adhesive patch on the chest, worn like a Band-Aid, with one ECG lead. While 50 percent of patients found the Holter monitor to be unobtrusive, almost all patients found the Zio patch comfortable.

There are two main types of AFib, paroxysmal and persistent. Paroxysmal is acute, or sudden, and lasts for less than seven days, usually less than 24 hours. It tends to occur with greater frequency over time, but comes and goes. Persistent AFib is when it continues past seven days (3). AFib is a progressive disease, meaning it only gets worse, especially without treatment.

Medications are meant to treat either the rate or rhythm or prevent strokes from occurring. Those that treat rate include beta blockers, like metoprolol, and calcium channel blockers, such as diltiazem (Cardizem). Examples of medications that treat rhythm are amiodarone and sotalol. Then there are anticoagulants that are meant to prevent stroke, such as warfarin and some newer medications, dabigatran (Pradaxa), rivaroxaban (Xarelto) and apixaban (Eliquis). The newer anticoagulants are easier to administer but may have higher bleeding risks, in some circumstances with no antidote.

There is also ablation, an invasive procedure that requires threading a catheter through an artery, usually the femoral artery located in the groin, to reach the heart. In one type of ablation, the inappropriate nodes firing in the walls of the atria are ablated, or destroyed, using radiofrequency. This procedure causes scarring of atrial tissue. When successful, patients may no longer need medication.

Premature atrial contractions

Premature atrial contractions, abnormal extra beats that occur in the atrium, may be a predictor of atrial fibrillation. In a study, PACs alone, when compared to the Framingham Heart Study AFib risk algorithm (a conglomeration of risk factors that excludes PACs) resulted in higher risk of AFib (4). When there were more than 32 abnormal beats/hour, there was a significantly greater risk of AFib after 15 years of PACs. When taken together, PACs and the Framingham model were able to predict AFib risk better at 10 years out as well. Also, when the number of PACs doubled overall in patients, there was a 17 percent increased risk of AFib.

The role of obesity

There is good news and bad news with obesity in regards to AFib. Let’s first talk about the bad news. In studies, those who are obese are at significantly increased risk. In the Framingham Heart Study, the risk of developing AFib was 52 percent greater in men who were obese and 46 percent greater in women who were obese when compared to those of normal weight (5). Obesity is defined as a body mass index >30 kg/m², and normal weight as a BMI <25 kg/m². There were over 5,000 participants in this study with a follow-up of 13 years. The Danish Diet, Cancer and Health Study reinforces these results by showing that obese men were at a greater than twofold increased risk of developing AFib, and obese women were at a twofold increased risk (6).

Now the good news: Weight loss may help reduce the frequency of AFib episodes. That’s right; weight loss could be a simple treatment for this very dangerous arrhythmia. In a randomized controlled trial, the gold standard of studies, those in the intervention group lost significantly more weight, 14 kg (32 pounds) versus 3.6 kg (eight pounds), and saw a significant reduction in atrial fibrillation severity score compared to those in the control group (7). There were 150 patients involved in the study.

An AFSS includes duration, severity and frequency of atrial fibrillation. All three components in the AFSS were reduced in the intervention group compared to the control group. There was a 692-minute decrease in the time spent in AFib over 12 months in the intervention arm, whereas there was a 419-minute increase in the time in AFib in the control group. These results are potentially very powerful; this is the first study to demonstrate that managing risk factors may actually help manage the disease.

Caffeine

According to a meta-analysis (a group of six population-based studies) done in China, caffeine does not increase, and may even decrease, the risk of AFib (8). The study did not reach statistical significance. The authors surmised that drinking coffee on a regular basis may be beneficial because caffeine has antifibrosis properties. Fibrosis is the occurrence of excess fibrous tissue, in this case, in the atria, which most likely will have deleterious effects. Atrial fibrosis could be a preliminary contributing step to AFib. Since these were population-based studies, only an association can be made with this discovery, rather than a hard and fast link. Still, this is a surprising result.

However, in those who already have AFib, it seems that caffeine may exacerbate the frequency of symptomatic occurrences, at least anecdotally. With my patients, when we reduce or discontinue substances that have caffeine, such as coffee, tea and chocolate, the number of episodes of AFib seems to decline. I have also heard similar stories from my colleagues and their patients. So, think twice before running out and getting a cup of coffee if you have AFib. What we really need are randomized controlled studies done in patients with AFib, comparing people who consume caffeine regularly to those who have decreased or discontinued the substance.

The bottom line is this: If there were ever a reason needed for obese patients to lose weight, treating atrial fibrillation should be on the top of the list, especially since it is such a dangerous disease with potentially severe complications.

References:

(1) Am J Cardiol. 2013 Oct. 15;112:1142-1147. (2) Am J Med. 2014 Jan.;127:95.e11-7. (3) Uptodate.com. (4) Ann Intern Med. 2013;159:721-728. (5) JAMA. 2004;292:2471-2477. (6) Am J Med. 2005;118:489-495. (7) JAMA. 2013;310:2050-2060. (8) Canadian J Cardiol online. 2014 Jan. 6.

Dr. Dunaief is a speaker, author and local lifestyle medicine physician focusing on the integration of medicine, nutrition, fitness and stress management. For further information, visit www.medicalcompassmd.com or consult your personal physician.

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