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Iwao Ojima and Martin Kaczocha (foreground) led the Stony Brook team in developing its class of Fatty Acid Binding Proteins (FABPs) a promising set of drug targets for new therapies. Photo by John Griffin, Stony Brook University

The “FABP” inhibitor is part of a series of compounds that uses the body’s natural marijuana-like substances to curb pain and inflammation

 Six years ago Stony Brook University through the Research Foundation for the State University of New York licensed a promising technology to Artelo Biosciences that identified Fatty Acid Binding Proteins (FABPs) as drug targets of the body’s endocannabinoid system for a potentially promising way to treat pain, inflammation and cancer. Now the first one of these compounds has been cleared by the Food and Drug Administration (FDA) for human clinical trials.

Artelo announced this week that the FDA’s initial approval of one of the FABP5 (5 indicates a specific protein) selective compounds called ART26.12 enables the company to initiate its first human phase 1 single ascending dose study of the drug. The company states that ART26.12 will address a critical need for cancer patients, treating chemotherapy-induced peripheral neuropathy. Phase 1 clinical trials are expected to be launched internationally during the first half of 2025.

ART26.12 is the lead compound in the series of FABP5 inhibitors under development. In 2018, Artelo received an exclusive license to the intellectual property of all FABP inhibitors for the modulation of the endocannabinoid system.

The work on FABPs originated with Iwao Ojima, PhD, SUNY Distinguished Professor in the Department of Chemistry at Stony Brook University, Martin Kaczocha, PhD, Associate Professor in the Department of Anesthesiology in the Renaissance School of Medicine at Stony Brook University, and Dale Deutsch, PhD, Professor Emeritus in the Department of Biochemistry and Cell Biology at Stony Brook University, a research collaboration affiliated with  the Institute of Chemical Biology and Drug Discovery (ICB & DD). They identified the action of FABPs as drug targets. Specifically, FABP5 was identified as the intracellular transporter for the endocannabinoid anandamide (AEA), a neurotransmitter produced in the brain that binds to cannabinoid receptors.

The research group demonstrated in the laboratory that elevated levels of endocannabinoids can result in beneficial pharmacological effects on stress, pain and inflammation and also ameliorate the effects of drug withdrawal. Drs. Ojima (also Director of the ICB & DD), Kaczocha, Deutsch and colleagues discovered that by inhibiting FABP transporters, the level of AEA is raised. The finding provided the basis for the drug development approach to elevate the levels of AEA.

Artelo took this concept and approach to further develop the compounds. Their scientists collaborated with the Stony Brook team to reach new findings that has led to the commercialization and use of the first drug (ART26.12) in a potential pipeline of drugs to treat pain and inflammation.

After the license to Artelo was finalized, Drs. Ojima and Kaczocha under a contract with Artelo synthesized and evaluated compound candidates with high FABP5 potency and selectivity, an effort that culminated in the development of the lead candidate, SB-FI-1621, which Artelo named ART26.12.

“This is the first clinical stage compound targeting the FABP pathway, an important and exciting milestone,” says Sean Boykevisch, PhD, Director of Intellectual Property Partners in Stony Brook’s Technology Transfer Office. “The fundamental and translational research conducted by the Stony Brook team and their subsequent collaboration with Artelo resulted in a true bench-to-bedside program with the goal of better patient experiences and outcomes.”

“We look forward to sharing the initial clinical results with ART26.12 next year,” says Gregory D. Gorgas, President and CEO of Artelo Biosciences. “As the leading company pursuing FABP inhibition we are committed to building on the unique, lipid-modulating mechanism of our FABP inhibitor platform to address life-altering pathologies for which there are few, if any, safe and effective pharmaceutical treatments.”

For more about the Stony Brook research that developed FABP inhibitors and the grant to support years of research, see this news.

For more details on the FDA clearance news of the drug, and Artelo’s R&D plan, see this news.

 

 

Cedar Beach in Mount Sinai. Wikimedia Commons photo

By Peter Sloniewsky

On Thursday, June 11, Suffolk County Executive Ed Romaine (R) was joined by Brookhaven Town Supervisor Dan Panico (R) and Councilwoman Jane Bonner (R-Rocky Point) to promote a new I/A water filtration system, soon to be installed at Cedar Beach.

Innovative and Alternative On-Site Wastewater Treatment Systems use advanced treatment methods to remove nitrogen and other pollutants from wastewater before it is released into the environment.

As of July 2021, Suffolk County requires installment of I/A systems for most new residential construction projects. However, much of Long Island, especially Suffolk, uses septic systems instead of sewers due to the area’s historic low population density. While septic systems are cost-effective and efficient, increases in population have led to nitrogen pollution in both surface-level and underground bodies of water. This nitrogen pollution causes harmful algal blooms, which can destroy ecosystems by consuming excess oxygen in water and cause a variety of conditions in exposed humans.

The more-than 1.5 million people of Suffolk County rely on more than 380,000 cesspools and wastewater systems, including over 209,000 systems located in areas that already have environmental risks. Bonner, who represents the town’s District 2, told TBR News Media that “we have a water problem, with a direct correspondence to cesspools.”

Additionally, the sewer systems already in place on Long Island have a tendency to contribute to road runoff, with a similar effect of nitrogen pollution. When there is more water than sewer pipe systems can handle, partially treated wastewater can flow directly into nearby bodies of water, which can include waste, pesticides, oil and litter. Bonner clarified that “the topography [of the North Shore] lends itself to road runoff … I/A systems and sewers will certainly help that.”

In Suffolk County, there are two types of I/A systems which have been approved by the Department of Health Services — FujiClean and HydroAction. Both technologies have been proven to reduce total nitrogen levels far below the county standard, and to reduce those levels more than 80% from conventional septic systems (which do not typically meet the standard).

The Cedar Beach filtration system will be paid for by a $100,000 grant funded by the Water Quality Protection and Restoration Program. This program was revised and extended in late June, and was sponsored by Romaine.

Revisions to the program include the establishment of a referendum for this November’s general election ballot, which, if approved, would establish an additional sales tax of one-eighth of 1 percent to fund a new Water Quality Restoration Fund. Romaine claimed he “cannot emphasize enough the importance of this referendum” to address water contaminants, and the language of the referendum itself claims that its passage will ensure “county funding to 2060 for clean water projects, improvements in drinking water, bays and harbors” — such as the I/A system to be installed at Cedar Beach.

Bonner told TBR News Media that this new fund would be “split between I/A systems and sewers,” and Romaine described the fund as vital to fund sewer construction especially in less developed areas of the county.

An aedes albopictus mosquito, better known as the Asian tiger mosquito. Pixabay photo

By Daniel Dunaief

Mosquitoes can be much more than a nuisance as they search for their next blood meal: they can also pass along potentially dangerous viruses.

Long considered a tropical and subtropical health threat, dengue fever has reached record levels in the Americas this year. The illness has been traveling with Aedes mosquitoes that have been moving further north amid global climate change.

As of early July, mosquitoes in Texas, Florida and California have had one of the four viruses associated with the disease. Through early July, Florida reported 10 cases from local spread, according to an American Medical Association update.

Suffolk County residents who have traveled into areas that have dengue have contracted the illness, which has symptoms that are similar to the flu, such as high fever, headaches, body aches, nausea, vomiting and a rash.

Suffolk County has reported 12 cases of travel-related dengue so far through early July, which is more than all of last year and is the highest level since 2013, when 13 cases were reported for the entire year.

“We do have a fair amount of concern with global warming,” said Dr. Sharon Nachman, Chief of the Division of Pediatric Infectious Diseases at Stony Brook Children’s Hospital. “Even if people do not believe in it, mosquitoes have changed where they’re located. There is concern that the mosquitoes” will continue their trek farther north.

Suffolk County is one of many places throughout the country and the Americas that have reported an increase in cases for a disease for which residents have generally had no exposure and, as a result, no natural immunity.

New York State Department of Health alerted medial professionals to consider dengue as a diagnosis if people who are sick have a travel history and related symptoms, Dr. Gregson Pigott, Suffolk County Health Commissioner, explained in an email.

Symptoms of dengue typically begin within two weeks of being bitten by an infected mosquito.

From January 1 through June 24, countries in the Americas reported more than 9.7 million dengue cases, twice as many as in all of 2023, according to the Centers for Disease Control and Prevention.

Indeed, in Puerto Rico, infection levels climbed so high in early April that the Puerto Rico Health Department declared a public health emergency.

While a majority of dengue infections are asymptomatic or produce mild illnesses, the virus can cause severe cases and can be fatal, according to the World Health Organization.

“Anyone who lives in or travels to an area with risk of dengue is at risk for infection,” Pigott explained. “Children and those who are elderly are at higher risk for serious illness.”

People with dengue typically receive supportive care, which includes rest, pain medications and fluids.

Protection

Health professionals urged people traveling to areas with dengue to take a number of steps to protect themselves.

EPA-registered insect repellents, coupled with loose-fitting, long-sleeved shirts and pants can keep mosquitoes away.

Additionally, people can treat their clothing and gear, including hats, shoes and socks, with permethrin.

“Don’t be around standing water, which is a wonderful place for mosquitoes to breed,” advised Nachman.

In Suffolk County, the arthropod-borne disease lab collects mosquitoes and sends them to the New York State Department of Health lab in Wadsworth, New York. Asian tiger mosquitoes, which have carried dengue, zika and chikungunya viruses, have been found in Suffolk County, Pigott added.

“No samples of Aedes albopictus mosquitoes that have been sent to the lab have tested positive for those viruses,” Pigott wrote.

While health professionals are on the lookout for potential cases of dengue among residents who have traveled, they are more concerned currently with West Nile virus, which people can contract locally.

Other local illnesses

As for illnesses in the county, Nachman has seen patients who have been battling a collection of viruses, including enteroviruses and Covid.

Residents who are staying around Long Island should continue to be careful about ticks that can carry Lyme disease. Anyone who is going hiking should consider long pants and long sleeves, as well as dirt on their clothing.

“If you take your kids out to hike, check them and you for ticks,” said Nachman.

Photo courtesy of NYCBS

New York Cancer & Blood Specialists (NYCBS), recently opened a new state-of-the-art comprehensive cancer center at 1500 Route 112, Building 1 in Port Jefferson Station. The center is approximately 18,000 square feet and just across the parking lot from its previous location in Building 1.

“Our new facility represents a significant step forward in our mission to deliver world-class cancer care,” said Dr. Jeff Vacirca, Chief Executive Officer of NYCBS. “With this new space, we can see even more patients, ensuring everyone receives the timely and comprehensive care they need. This move allows us to provide integrated, patient-centered care in a modern and comfortable setting, reflecting our dedication to improving patient outcomes and experiences.”

According to a press release, the new facility, equipped with cutting-edge technology and expanded services, is designed to enhance patient care and comfort. NYCBS’s experienced oncologists will continue to provide comprehensive cancer care using the latest advancements. The new facility increases capacity, with 33 infusion chairs and 26 exam rooms, ensuring reduced wait times for timely and efficient treatment.

The advanced radiology department offers precise diagnostic imaging, featuring a 64-slice Evo CT scanner and ultrasound capabilities. A unique and significant feature of the new facility is the dedicated wellness suite, established through a partnership with Mondays at Racine. This suite provides free services to patients, such as oncology massage, skincare, and beauty treatments, to support their overall well-being. 

For more information, visit nycancer.com or call 631-751-3000.

Mather Hospital. Photo by Jim Lennon

Mather Hospital, 75 North Country Road, Port Jefferson has opened a special monitoring unit for individuals with epilepsy. Patients will come in for multi-day admission and will undergo continuous video electroencephalography (EEG), which will allow the healthcare team to make a more accurate diagnosis and treatment recommendations.

Consisting of four single beds in the hospital’s 3 North patient unit, the Epilepsy Monitoring Unit (EMU) is staffed by epileptologists, neurologists, nurses, hospitalists, and EEG technicians. The unit is headed by Usman Mirza, MD, who completed his residency in neurology and a fellowship in EEG/Epilepsy, both at Hofstra Northwell School of Medicine. 

“The Epilepsy Monitoring Unit is very important in the optimal evaluation and management of patients living with epilepsy and suffering from seizure-like events,” Dr. Mirza said. “Studies show that longer video EEG recordings increase the chances of capturing brain wave abnormalities. Furthermore, the data obtained about their seizures/events can be a vital learning tool for patients and families to be better prepared and to play a stronger role in their treatment plans.”

Video EEG  uses a video camera and recorder to track brain wave activity during and between seizures so doctors can review and analyze what happens when the patient has a seizure and determine the best course of treatment.  Other times, patients who may be having seizure-like events benefit from being evaluated in the EMU to clarify diagnosis and guide management.

Referrals to the unit will be made by a neurologist or other healthcare providers in consultation with neurology.

“This new program is another example of how Mather Hospital embraces innovative ways to raise the health of the community and exceed expectations of what healthcare should be,” said Kevin McGeachy, Executive Director.

Photo courtesy of Long Island Game Farm

The Foundation for Wildlife Sustainability continues the second season of its Senior Social Club at the Long Island Game Farm, 489 Chapman Blvd., Manorville on Fridays, July 26, August 9 and August 23 at 10:30 a.m. 

“We’re excited to bring back our Senior Social Club for another season,” shares Long Island Game Farm president Melinda Novak. “We introduced this program last year and it was a hit! Now working with our new nonprofit arm, the Foundation for Wildlife Sustainability, we can expand our educational programming across the game farm. It’s very special to have a social club for our senior community and offer ways for them to connect with nature, animals, and each other.”

Senior citizens (65 years+) will begin the morning exploring the grounds, visiting animals, and learning more about the various species at the game farm. A presentation in Woodland Hall will follow, with topics varying each week from rescued animals to wonders of wool, birding to nature photography, and more.

Seniors will enjoy a discounted admission of $10 to Long Island Game Farm on Senior Social Club days. For reservations, call 631-878-6644. 

There are many reasons why estate planning is important.

Join Burner Prudenti Law, P.C. for an Estate Planning seminar titled Protecting Assets: Should I Put My Home in a Trust? at Sachem Public Library, 150 Holbrook Road, Holbrook on Tuesday, July 23 at 6:30 p.m. The program will cover how to protect assets, including property and second homes, the ways to reduce and eliminate taxes, and the importance of having a sound estate plan in place. To register visit burnerlaw.com/seminars-webinars/ or call 631-646-2733.

 Offering A Unique Floral Experience On Eastern Long Island

Horton’s Flower Farm, 712 Horton Avenue, Riverhead  announced on July 13 that it is open for the season.  Nestled among the region’s famous wineries, Horton’s Flower Farm offers a unique opportunity for visitors to handpick their own bouquets from over 100 varieties of cut flowers.

“When you visit our farm, you’ll experience what hundreds of others have described to us: peace, serenity, and an escape from the noise and hustle of everyday life. Our farm is a throwback to a quieter, more serene time. Walking in the fields and cutting the flowers is as therapeutic as it is beautiful,” said co-owner Jeffrey Gross.

The farm is open daily from 11 a.m. to 4 p.m. with Sunset Picking available from 6 to 8 p.m. (Friday & Saturday only). Admission for adults is $3 and $2 for kids. Veterans, Nurses, Teachers, Seniors, and well-behaved, leashed dogs get in free.

When visitors first arrive at Horton’s Flower Farm, they choose the size of their bouquet based on the number of stems they want to pick. Each bouquet includes a mason jar to take home. After picking, guests are welcome to relax and enjoy the garden, have a picnic, or play games.

Additionally, anyone who buys flowers this season can win a lifetime of free flowers.

“On August 18th, five lucky people will be chosen to attend the Golden Ticket event. One winner will receive a lifetime of flowers, and the other four will receive a Family Pack of four passes for this season and next. Buy a bouquet, enter your email, and you’re in!” said co-owner Claudette Gross.

Group Bookings are available for Girl Scouts, bridal parties, bus tours, and more. Professional Photography services are available for families, couples, and special occasions.

“Plan your family visit to Horton’s Flower Farm. Create bouquets with your loved ones, enjoy a picnic at our tables, and let the kids play on our swing set and engage in family games. For couples, the farm offers a romantic experience where you can pick flowers together and enjoy the picturesque surroundings,” added Claudette Gross.

To learn more about Horton’s Flower Farm, call 516-860-9528 or visit https://www.hortonsflowerfarm.com/

This article originally appeared in TBR News Media’s senior supplement Prime Times on July 18.

 

By Daniel Dunaief

Paula S. Apsell wants to correct one of the more insidious myths about Jews during the Holocaust.

Director Paula S. Apsell

The award-winning filmmaker is showing the documentary Resistance – They Fought Back at the Cinema Arts Centre in Huntington on July 25, offering numerous examples of Jews who fought against the murderous Nazi regime.

The film from Apsell, who will be at the Cinema Arts Centre screening to speak with the audience, chronicles resistance in many forms, from getting married in secret, to having children, to holding concerts, to caring for the poor, to smuggling food and weapons into ghettos and, ultimately, to guerilla combat.

These stories of courage and a readiness to fight back when any form of resistance could mean severe punishment or death not just for the person rebelling but for many others paint a completely different picture than the one in which Jews surrendered meekly to their fate.

“There were seven rebellions in death camps, and six of them were led by Jews,” said Apsell, who won numerous awards as executive producer for PBS NOVA films. “They still mustered the courage to rebel knowing they would die in the rebellion” and almost all of them did.

The survival rate among Jews in general and those who the Germans found were rebelling, which includes many in their late teens and early 20’s who were fighting to protect and defend their families, was low.

While she was an executive producer at PBS for the Nova science series in 2016, Apsell traveled to Lithuania near Vilnius, where she produced a documentary for PBS about Jews who were brought to a site to burn the bodies of thousands of other Jews whom the Nazis had murdered.

At night with shackles on, they used spoons to dig a tunnel over the course of 76 days. When they escaped, they filed off their shackles and raced towards a forest, with 11 of them surviving through the rest of the war.

Building on this story, Apsell, who worked with Lone Wolf Media and co-directed the documentary with Kirk Wolfinger, started gathering information for the Resistance film in 2019 and completed editing the movie in September of 2023.

Apsell, who herself is conservative about what she shares with her eight and 11-year old grandchildren, suggested the documentary is appropriate for juniors in high school or older, unless they have had some level of education about the Holocaust.

Compelling lives

Amid the many stories of courage and sacrifice, Apsell felt a particular connection with Bela Hazan.

A courier who brought information, money and weapons to the ghettos, Hazan posed as a Polish Christian woman and traveled along dangerous roads surrounded by Nazis who would imprison, torture or kill her if they knew of her work.

After Hazan survived the dangers of the war, her son Yoel Yaari, who hadn’t heard of his mother’s wartime activities, found two notebooks containing details about her work.

Yaari, who is the Henri and Erna Leif Professor for Research in Neurodegenerative Diseases at the Hebrew University Faculty of Medicine in Jerusalem, has told people through articles and his book “Portrait of a Woman” about his mother’s “astounding courage and what she had done for the Jewish people,” said Apsell. “We can all learn about courage in adversity.”

Apsell suggested that scholars knew about the way Jews had resisted, but that lay audiences often say they thought Jews went to their death as sheep to the slaughter.

Other ways to watch the film

Apsell is in the final stages of putting together a broadcast deal, which she hopes will be ready in January to coincide with Holocaust Remembrance Day, which is on January 27.

She also plans to work with organizations that have relationships with schools and libraries so students can access the information.

These stories “ought to be a much more visible part of the history of the Holocaust,” she said.

“I had a mission to tell these stories,” Apsell said. “I felt like it was a personal commitment and a responsibility” to share these stories.

While Apsell appreciates and acknowledges that people who weren’t Jewish helped their Jewish friends, neighbors and even strangers, she felt like the focus on resistance has often been on outside help.

“In this film, my emphasis was on Jews rescuing other Jews,” she said.

The film includes interviews with five Jewish survivors who were among the resistance fighters. Resistance also uses considerable archival footage from organizations that had recorded interviews. The film’s narrators include actors Corey Stoll, Dianna Agron and Maggie Siff.

Dr. Jud Newborn, lecturer, author and curator at the Cinema Arts Centre, had an immediate reaction when he viewed the film.

“I was stunned,” said Newborn, who is an expert on Jewish anti-Nazi resistance and served as the founding historian of New York’s Museum of Jewish Heritage. “No documentary covers the panoply of Jewish resistance in its many forms and in such a moving as well as revelatory manner.”

Newborn, who will host a discussion with Apsell right after the screening, added that he thought this was a “groundbreaking film.”

While Newborn describes all manner of Jewish resistance in his multimedia lecture programs, he learned new stories because the movie pulls together “the most cutting edge information,” he said. “The subject of Jewish resistance breaks stereotypes and is deeply inspiring and energizing and it’s also deeply moving because they had to overcome obstacles unlike any people under Nazi occupation or indirect rule.”

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The Cinema Arts Centre, 423 Park Ave., Huntington will screen Resistance – They Fought Back on Thursday, July 25 at 7:15 p.m. with filmmaker Paula S. Apsell in person followed by discussion with moderator Dr. Jud Newborn. Tickets are $18 per person in advance at  www.cinemaartscentre.org or at the box office.  For more information, please call 631-423-7610.

 

Rendering of artist locations around the village for the Music Throughout the Village event. Photo courtesy Port Jefferson Chamber of Commerce
Local organizations collaborate to host weekly event

By Aramis Khosronejad

This past weekend, a musical addition to the Port Jefferson community has been added to the charming local streets, Music Throughout the Village.

A collaboration between The Greater Port Jefferson Chamber of Commerce, the Greater Port Jefferson-Northern Brookhaven Arts Council and Port Jefferson Retailers Association, it is a program that will bring music to this cozy, small town.

This summer event consists of local musicians, who will have the opportunity to play for spectators at set locations. Passersby will be able to “shop and dine in our community,” according to the retailers association, while enjoying the relaxing ambiance.

The ultimate goal for this musical program is to get it “codified” so it can become a permanent fixture of the community, said Barbara Ransome, director of operations for the chamber of commerce.

The program will run every Saturday and Sunday from 2 to 4 p.m. from July 13 to Oct. 20. Each musician has been carefully reviewed and vetted by the arts council.

Through the coming weekends, the musicians can be heard in select locations around the village.

“There are four locations though that can, certainly, be expanded,” Ransome said. The current venues are at the intersection of Arden Street and Main Street in downtown Port Jefferson (next to the local Starbucks), as well as by the popular restaurant Salsa Salsa on Main Street, the Kate & Hale store on East Main Street and, finally, near Tiger Lily Café further down East Main.

This past weekend’s musicians, Hank Stone, Denise Romas, Faith Krinsky and Karl Blessing, were from a variety of musical genres.

“What better way than to walk through a beautiful town hearing beautiful music?” said a spokesperson from the retailers association.

To view a map of current and future concert locations and for additional information, go to the chamber of commerce and retailers association’s Instagram pages, also the respective Facebook pages.