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TBR News Media covers everything happening on the North Shore of Suffolk County from Cold Spring Harbor to Wading River.

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Above, Kim Plaspohl fires a pitch from the mound. Photo by Bill Landon

By Bill Landon

Both teams stranded runners on base after several innings, but the Smithtown West softball team left fewer players stranded, to pull out a 4-0 victory over visiting Newfield on a cold, dreary Tuesday afternoon in a League II matchup.

Newfield senior Jennifer Sarcone struck first with a deep shot to left center for a standup double but was stranded at the bottom of the first.

Danielle Balsamo reached for the ball but not in time to make the out. Photo by Bill Landon
Danielle Balsamo reached for the ball but not in time to make the out. Photo by Bill Landon

Smithtown West sophomore Tara Killeen drove in senior Kassie Furr on a sacrifice fly to give her team a 1-0 lead to start the second inning, and the duo did it again in the top of the third when Killeen smacked a fly ball to right field to drive in Furr to take a two-run advantage.

“I didn’t think we came out with as much energy as we normally do,” Newfield pitcher Tabitha Butler said. “We should’ve got more lift on the ball. All we were doing is driving balls into the ground right at them so we weren’t’ finding the gaps.”

Smithtown West head coach Dave Miller sent in freshman right fielder Madison Mulder to pinch run at first, who stole second base on the very next pitch, but again, the Bulls stranded a runner on base.

Newfield head coach Jessica Palmaccio said her team didn’t execute when the opportunity presented itself.

“They were exactly what we thought they would be,” Palmaccio said. “They’re a good team. We’re a good team, but we didn’t do what we needed to do today. That’s all.”

Smithtown West lit up the scoreboard once more when Furr drilled a hit to rightfield to drive in sophomore Kaitlyn Loffman to edge ahead 3-0 in the bottom of the fifth.

“We came out knowing what to expect and we came out ready to play with good communication,” Smithtown West senior pitcher Kim Plaspohl said. “I felt confident because I knew my team would back me up.”

Furr, who defensively collected two line drives in the dirt to stop both, was there for her pitcher.
“I just knew I needed to support my pitcher and a play like that could mean the game,” she said. “So I knew when it was hit I needed to do whatever I had to do to get to it.”

Kiley Magee makes a catch. Photo by Bill Landon
Kiley Magee makes a catch. Photo by Bill Landon

Newfield’s Butler thought that her movement could’ve been better to help her team not just from the plate but from the mound.

“I didn’t hit all of my spots and that’s where they took advantage of it,” she said. “That’s where they got their hits.”

Killeen, in scoring position, was driven home by Smithtown West sophomore Amber Meystrik’s bat to take a 4-0 lead into the bottom of the sixth.

“Their energy was more than ours was today,” Sarcone said. “We had opportunities today that we didn’t take advantage of.”

Newfield threatened late, but couldn’t capitalize and fell to Smithtown West to drop to 2-3, while the Bulls improve to 2-1.

“I thought the girls played very, very well,” Miller said. “My pitcher was great. She didn’t walk anybody and our short stop [Furr] played better than I’ve ever seen her play. She’s a four-year varsity player.”

Smithtown West was scheduled to travel to Riverhead on Wednesday while Newfield was slated to host Copiague.

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By Leah Dunaief

“Woman in Gold” is based on a true story. It is also eerily similar to another true story to which I am privy.
The movie, currently playing in limited release and shortly to move into local theaters, is about an octogenarian Jewish woman who struggles to reclaim paintings looted from her family by the Nazis a half-century earlier.

Dame Helen Mirren plays Maria Altmann, an Austrian who barely escaped with her new husband before the jaws of Nazi death clamped down on Jews and dissidents following Austria’s annexation by Germany in 1938. Ultimately, they lived out their lives in Los Angeles, but much of their extended family stayed and perished in the Holocaust. Their possessions were confiscated, including five paintings by Gustav Klimt. Those paintings, including “Portrait of Adele Bloch-Bauer,” became Austrian icons; but for Maria Altmann, the portrait was simply of her Aunt Adele. The loss of those paintings came to symbolize the terrible loss of her immediate family, her home and her world.

As the years went by, claims of looted property began to surface. In the 1990s, Maria Altmann tried to reclaim her family’s art through the early channels for such action in Austria. She encouraged the son of a friend, a young and struggling lawyer, to represent her. He is the grandson of one of Austria’s most famous musicians, Arnold Schoenberg. He is also an American with little emotional connection to his grandfather’s country, nor Altmann’s cause, but he was initially attracted to the fight for the potential monetary windfall. Their battles with the Austrian government continued for a decade, during which they were aided by an Austrian journalist.

In a similar story, my friend Alice was also born in Austria and lived with her parents and brother in Vienna until the Nazi annexation. Her father was a lawyer, and when warned by one of his clients that he was on the round-up list for the next morning, he managed to escape with his immediate family to the west. They, too, eventually arrived in America, having left all their possessions behind in their hasty flight. One of their pieces of art was an original drawing by Picasso. Alice and her brother, now the rightful heirs, determined to enter claim for their stolen art, especially the most valuable piece by Picasso.

Their claim dragged on through the courts for the better part of a decade, roughly at the same time as that of Maria Altmann although much less in the news. Remarkably, they too were joined in their struggle by an Austrian journalist, whose efforts ultimately helped make the claim successful.

Like Altmann and E. Randol Schoenberg, Alice and her brother, against their will, returned to Vienna for hearings. It was an emotional journey back to the streets of their childhood for them. The film does justice to Altmann’s terrible memories with repeated cuts back in time to the growing atrocities of the late 1930s.
There is another interesting parallel when the claims succeeded. In the movie, the primary Austrian antagonist asks for some sort of shared ownership from Maria Altmann. His suggestion is curtly dismissed by Mirren. As my friend Alice was handed the framed Picasso by an Austrian official, she was told sarcastically that she’d “probably just sell it for the money!” to which she replied, “And that is now none of your business.”

She did not sell it, but rather gave it a position of honor in her Washington Heights apartment. It was, for her, the tiniest satisfaction from a bitterly lost world.

Maria Altmann did sell the painting of Adele Bloch-Bauer to Ronald Lauder, Estée Lauder-heir and owner of the Neue Gallery of Austrian Art on 86th St. and Fifth Ave. in New York. She used the money to help Schoenberg establish his law practice and to help both family members and charities close to her heart.

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By Daniel Dunaief

Every defeat, rejection, or failure can be like a drop of ice water on the back of our necks. We often can’t brush those droplets away and they seep into us, weighing us down, causing our feet to shuffle and shoulders to slump.

The self-esteem bashing moments in a week, month, or year can build up, turning us into a balled-up, wet rag in the corner of a dark room.

Certainly, the sunlight and warmth of spring can dry some of that out, as the chirping of newly hatched birds, the sight of children chasing after a ball on a playground and the scent of fresh flowers can evaporate the dreaded droplets.

And yet, that’s often not enough. We sometimes need more to turn ourselves into ice-water-resistant creatures who can tackle any assignment, avoid obstacles, or remain undeterred in the face of significant opposition.

Where do we find this relief? Some get it from exercise, where they perspire out those metaphorical drops of ice water. As they push themselves along the pavement or across glistening fields, they generate momentum, release endorphins, and become like the Little Engine That Could, remembering that a healthy dose of believing in themselves works.

Others get it from talking on the phone, writing in a diary or a blog, escaping to the movies, diving into books, or sharing a laugh with friends they’ve known for years.

What we sometimes need in our lives is a catharsis. You remember that Greek word for that moment when someone releases strong emotions, obtaining relief at the same time? We learned about this some time when we were in middle or high school.

Recently, my middle school daughter received an assignment that seemed like a confusing and challenging juggling act. She finished George Orwell’s “Animal Farm.” Her language arts teacher asked his students to find a song in which they saw an overlap with a theme from the book. They also had to relate that theme to their lives.

When my daughter came home from her first day of these presentations, she described in detail, how two of the four presenters broke down in tears as they shared their stories. In other classes, several students, including one of the untouchable “popular kids,” cried in front of his class as well. One of the students described his frustration with his frequent movement from one school to another as his parents’ jobs required starting over again every year or so. He looked out at the classroom, his teary eyes revealing his deep discomfort, and said he was sure no one in the room would be his friend for longer than the short time he’d be in town. He was resigned to the fact that he’d be a sad ghost someone might remember at graduation.

Another student shared the challenge of dealing with an impossible relative. This person pushed away any connection to a family she used to have, slamming the door, literally and physically, on anyone from her past who dared approach her. The disillusionment her father felt was magnified in her.

As my daughter thought of her assignment, her eyes welled up as well when she thought of the moment when something promising turned tragic. She had a spectacularly close connection with a young, vibrant first grade teacher whose life ended all too soon after a cancer diagnosis.

Even as my daughter described her feelings, I could see the small ice droplets that landed so hard on the back of her neck in elementary school, as they found an exit through her eyes. She will always remember that loss, but the catharsis more than five years later provided some relief.

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Arleen Buckley donated a kidney to her husband of 43 years, Tom Buckley. Photo by Erin Dueñas

By Erin Dueñas

Arleen Buckley ticked off the places she and husband Tom had traveled to before he fell ill. The Port Jefferson couple had visited Italy, Ireland and even China, but a planned trip to Belgium last year had to be canceled after Tom’s battle with polycystic kidney disease — a hereditary condition where cysts develop on the kidneys, leading to the organ’s failure — kept him from traveling.

“He was just too sick,” his wife said. “We were lucky we could get him to the corner.”

Tom Buckley spent months undergoing dialysis three days a week, but the treatments left him weak.

“He wasn’t having a good reaction to the dialysis,” Arleen Buckley said. “I told him we can’t live life like this. It was a tough time.”

Arleen Buckley said she couldn’t bear seeing her husband of 43 years so ill. She suggested giving him one of her kidneys to resolve his health issue but he refused.

“He felt guilty. He didn’t want me putting my life at risk,” she said. “I told him I wanted to live a nice long life — but with him.”

It took months but she eventually convinced her husband to take her kidney, and in September of last year, the couple underwent the surgeries.

Arleen Buckley was up and about just three days later, and while her husband’s recovery took much longer — about six months — he said he feels great. They’re even planning a trip to Scandinavia.

“I couldn’t go anywhere, not even to the movies,” Tom Buckley said. “Now that I’m better I can do whatever I want.”

Last Thursday, April 2, the couple attended the Living Donor Award Ceremony at Stony Brook University Hospital, which honored Arleen Buckley and about 200 other kidney donors. Sponsored by the hospital’s Department of Transplant, kidney recipients presented their living donors with a state medal of honor for the second chance at life.

The ceremony’s keynote speaker was Chris Melz of Huntington Station, who donated a kidney in 2009 to his childhood friend Will Burton, who suffered from end-stage renal failure. The surgeries were successful, and Melz now works with the National Kidney Foundation raising awareness for living donors.

“I want to spark the drive for people to do good,” he said. “Giving is a beautiful thing.”

Arleen Buckley said she was happy to give a kidney to her husband, whom she has known for 50 years.

“I told him, ‘When I was 14 years old, I gave you my heart. At 64, I gave you my kidney,’” the wife said.

Dr. Wayne Waltzer, director of kidney transplantation services and chair of the Department of Urology at Stony Brook University School of Medicine, called kidney transplants a “new lease on life” for patients who are on dialysis.

“Transplants restore them,” Waltzer said. “They get back the same sense of well-being they had before they got sick.”

According to the National Kidney Foundation, 118,000 Americans are on a waiting list for an organ —  96,000 of those wait for a kidney. Roughly 13 people die daily waiting for the organ, the group said.

Stephen Knapik, Stony Brook University’s living donor coordinator, said that every 10 minutes someone in need of a kidney is added to that list. He called it an honor to work with donors who keep the list from growing.

“I’ve never been in a room with so many superheroes in my life,” Knapik said. “The greatest gift you can give isn’t a boat or a car, it’s the gift of life.”

Waltzer said that donating a kidney involves meeting certain criteria including compatible blood groups and matching body tissues between donor and recipient, as well as ensuring that the recipient has no antibodies that will work against the transplanted organ.

While he said the surgery is sophisticated, he called the science and medicine an incredible achievement.

“The immunosuppressive therapy is so good and the medication so effective that you can override any mismatches,” he said.

This allows for donors to give to loved ones that are not related by blood.

With the most active renal transplant program on Long Island, Stony Brook has done 1,500 transplants since 1981. Waltzer said that donors are doing an “amazing service,” not just to their recipient but also to one of the thousands of people who are on the waiting list for a kidney.

“There is a shortage of organs,” he said. “By donating, you are giving a chance to someone else on that waiting list.”

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Dan DeCastro rips one deep into the outfield. Photo by Bill Landon

By Bill Landon

Having beaten Longwood the day before by just one run, the Ward Melville baseball team invaded the Lions’ territory Tuesday and let its pitching and batting do the talking to prove the Patriots’ worth. When the dust settled, the Patriots handed Longwood a 12-2 loss in the second matchup of a three-game series.

Alex Betz hurls a pitch from the mound. Photo by Bill Landon
Alex Betz hurls a pitch from the mound. Photo by Bill Landon

Ward Melville sophomore pitcher Ben Brown led the way with an impressive performance on the mound to earn the win in his first varsity start. Longwood struggled with the entire Patriots pitching staff, managing just six hits. The Lions were also plagued by four errors over seven innings.

Ward Melville blew the game open in the second inning, scoring six runs on an RBI double by Dominic Lamonica, a two-run double by Troy Davern, and Nick Rizzi drove in a run and with the help of two Longwood errors to give the Patriots a 6-0 lead.

“Today our hitters did a good job in their approach; we got a lot of clutch hits,” Ward Melville head coach Lou Petrucci said. “Dominic Lamonica had a big double in the second inning; Jeff Towle, Troy Davern and the middle-of-the-lineup guys did a good job.”

The Lions tried to claw their way back and scored two runs in the bottom of the third.

Towle took control of the fourth inning, blasting a shot to deep center field, giving both Nick Vitale and Joe Flynn the opportunity to come home for an 8-2 advantage.

“Today, as a team, we had great bats all around putting the ball in play, making them work, putting pressure on their defense and that helped us out today,” Towle said. “[Longwood is] a solid team, but the ball didn’t roll their way. That could’ve happened to us, but we hit the ball hard.”

Flynn was also excited to see the team putting the ball in play.

“Today we came out swinging with the right mind-set; we had to put the ball in play and do whatever we have to do to win,” he said. “We’re not a strong hitting team and we’ve relied on pitching in the past, and that’s what we’re going to do this year, but today we came out with the bats and did a great job.”

Troy Davern makes a grab for the out. Photo by Bill Landon
Troy Davern makes a grab for the out. Photo by Bill Landon

The Patriots crossed the plate once more in the inning, to surge ahead 9-2.

Petrucci said he was pleased with his entire lineup.

“The top of the order guys — Joe Flynn got on base; Nick Vitale had a great day today — those guys got on base and did a good job for us,” he said. “The big hitters drove them in with clutch hits and we had more base runners and took advantage of that opportunity.”

The Patriots found the scoreboard once in the top of the sixth and twice in the seventh to put the game away.

Brown said his team misjudged Longwood in the first game of the series.

“I think we came out with a lot of intensity,” he said. “We took this team a little lightly yesterday. We really played hard, we had really good at bats, so that was the difference today.”

With the win, Ward Melville improved to 3-0. The Patriots conclude their three-game series with Longwood on Thursday at home, with the first pitch scheduled for noon.

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An anti-Common Core rally in Smithtown. File photo

Opting students out of state standardized tests has become a hot topic, and it’s a decision that should rest in the hands of parents, not school leaders.

Recently, Comsewogue School District officials had threatened to consider not administering the tests altogether if Gov. Andrew Cuomo (D) and the state education department did not acquiesce on a list of demands, one of which was to stop weighing student test scores so heavily in teacher and administrator evaluations. But the district clammed up on the measure after its attorney intervened. In addition, the NYSUT union, which represents teachers across the state, has called for a mass opt-out.

State law comes down hard on actions like this: Any school-board members or other officials like superintendents who willfully violate state education regulations — such as by refusing to administer a required assessment — risk being removed from office by the education commissioner, and state aid could be withheld from the district.

At the heart of the matter is a battle over local control of our school districts. While local officials should be consulted when it comes to shaping state education regulations and standards, there must be some degree of state standardization in education to ensure that our programs sufficiently educate kids. It’s wrong for administrators and school officials to politicize a high-emotion situation — the opt-out movement — in a way that could be detrimental to students.

In a school-sponsored, massive opt-out, the ones who face the greatest risk are the students — officials may put their jobs at stake, but the kids’ entire futures could hang in the balance if the state pulls education aid from a district that heavily relies upon it, or if otherwise competent school board members and administrators are kicked out of office.

Let us also pause to think about how adult behavior affects our kids. This paper has previously editorialized about how the commotion over the Common Core and state testing has negatively affected children — students see and hear their parents’ and teachers’ reactions, and many mimic that fear and anxiety when they otherwise would not have had such emotional reactions to tests and classes. At some point, we have to ask ourselves if this is the kind of behavior we want to teach our kids.

Calling for change is one thing, but screaming for it is another. Let’s not play politics. Above all, let’s keep cool.

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Part of Andrea Drive in East Setauket needs to be repaired as of Tuesday. Photo by Elana Glowatz

By Julianne Cuba

Following another devastating winter on Long Island, Brookhaven Town is receiving a little boost from the New York State Department of Transportation’s Extreme Winter Recovery fund for the year 2015-16, Highway Superintendent Dan Losquadro (R) has announced.

The Highway Department will receive more than $501,000, while last year it received more than $400,000 in recovery funds in order to improve Brookhaven’s infrastructure. Prior to 2014, the town had not received any additional funding recovery funds for road damage.

“I want to thank the Long Island delegation for working with me on securing this desperately-needed funding for Brookhaven,” Losquadro said in a press release. “The past two winters have been historically harsh and wreaked havoc on town roadways. The more funding we receive, the more roads we can pave.”

Part of Pleasant Drive in East Setauket needs to be repaired as of Tuesday. Photo by Elana Glowatz
Part of Pleasant Drive in East Setauket needs to be repaired as of Tuesday. Photo by Elana Glowatz

In a phone interview, Losquadro said he is continuing to look for other sources of revenue from all levels of government in order to offset the cost to local taxpayers, whether in grants or funding from the federal government.

“There’s easily five times the amount of work that needs to be done that I have money for … maybe even six or seven times,” he said.

Within the next week — hopefully by April 15 — Losquadro said he hopes the resurfacing of the roads will start, weather permitting. Like last year, the work will likely continue right up until November, he said.

For the past two years, Losquadro said the town has been able to repair about 60 miles of roadway each year.

“I’m hoping to be able to match that, if not surpass that, this year,” he said. “If we’re able to get a little extra money from New York State like we did last year, every dollar we get is another roadway I can do.”

Losquadro said “it’s not dollar to dollar,” and if he can get assistance in paying for other projects that the Highway Department would have otherwise had to fund, then he could repurpose that money for roadway paving.

He referenced the traffic safety grant, which had been awarded for North Country Road in Miller Place, as an example of money that will now be free to allocate for repaving elsewhere in the town.

“That [grant] money will allow us to redo that section of roadway, a lot of the work we would have had to do there will now be covered by that grant,” he said. “That’s an award that’s already been awarded. We are seeking grants on all levels. We are looking for sources from revenue and assistance from everywhere we can.”

Losquadro said that advocating for additional funds for the resurfacing of roads is generally not normal, but there is just not enough money in the budget.

“While we were certainly not happy to see another severe winter, I am happy that we’re able to provide additional funding. State representatives listened to myself and other highway superintendents and were able to secure additional funding again this year,” he said.

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By David Dunaief

Now that spring has sprung, the pace of life tends become more hectic. Although some stress is valuable to help motivate us and keep our minds sharp, high levels of constant stress can have detrimental effects on the body.
It is very likely that there is a mind-body connection when it comes to stress. In other words, it may start in the mind, but it can lead to acute or chronic disease promotion. Stress can also play a role with your emotions, causing irritability and outbursts of anger, and possibly leading to depression and anxiety. Stress symptoms are hard to distinguish from other disorders but can include stiff neck, headaches, stomach upset and difficulty sleeping. Stress may also be associated with cardiovascular disease, with an increased susceptibility to infection from viruses causing the common cold and with cognitive decline and Alzheimer’s (1).
A stress steroid hormone called cortisol is released from the adrenal glands and can have beneficial effects in small bursts. We need cortisol in order to survive. Some of cortisol’s functions include raising the glucose (sugar) levels when they are low and helping reduce inflammation and stress levels (2). However, when cortisol gets out of hand, higher chronic levels may cause inflammation, leading to disorders such as cardiovascular disease, as recent research suggests. Let’s look at the evidence.

Inflammation
Inflammation may be a significant contributor to more than 80 percent of chronic diseases, so it should be no surprise that inflammation is an important factor with stress. In a recent meta-analysis (a group of two observational studies), high levels of C-reactive protein, a biomarker for inflammation, were associated with increased psychological stress (3).
What is the importance of CRP? It may be related to heart disease and heart attacks. This study involved over 73,000 adults who had their CRP levels tested. The research went further to suggest that increased levels of CRP may result in more stress and also depression. With CRP higher than 3.0 there was a greater than twofold increase depression risk. The researchers suggest that CRP may heighten stress and depression risk by increasing levels of different proinflammatory cytokines, inflammatory communicators among cells (4).
In one recent study, results suggested that stress may influence and increase the number of hematopoietic stem cells (those that develop of all forms of blood cells), resulting in specifically an increase in inflammatory white blood cells (5). The researchers suggest that this may lead to these white blood cells accumulating in atherosclerotic plaques in the arteries, which ultimately could potentially increase the risk of heart attacks and strokes. Chronic stress overactivates the sympathetic nervous system — our “fight or flight” response — which may alter the bone marrow where the stem cells are found. This research is preliminary and needs well-controlled trials to confirm these results.

Infection
Stress may increase the risk of colds and infection. Cortisol over the short term is important to help suppress the symptoms of colds, such as sneezing, cough and fever. These are visible signs of the immune system’s infection-fighting response. However, the body may become resistant to the effects of cortisol, similar to how a type 2 diabetes patient becomes resistant to insulin. In one study of 296 healthy individuals, participants who had stressful events and were then exposed to viruses had a higher probability of catching a cold. It turns out that these individuals also had resistance to the effects of cortisol. This is important because those who were resistant to cortisol had more cold symptoms and more proinflammatory cytokines (6).

Cortisol
When we measure cortisol levels, we tend to test the saliva or the blood. However, these laboratory findings only give one point in time. Thus, when trying to determine if raised cortisol may increase cardiovascular risk, the results are mixed. However, in a recent study, measuring cortisol levels from scalp hair was far more effective (7). The reason for this is that scalp hair grows slowly, and therefore it may contain three months’ worth of cortisol levels. The study showed that those in the highest quartile of cortisol levels were at a three-times increased risk of developing diabetes and/or heart disease compared to those in the lowest quartile. This study involved older patients between the ages of 65 and 85.

Lifestyle and the Cellular Level
Lifestyle plays an important role in stress at the cellular level, specifically at the level of the telomere, which determines cell survival. The telomeres are to cells as the plastic tips are to shoelaces; they prevent them from falling apart. The longer the telomere, the slower the cell ages and the longer it survives. In a recent study, those women who followed a healthy lifestyle — one standard deviation over the average lifestyle — were able to withstand life stressors better since they had longer telomeres (8).
This healthy lifestyle included regular exercise, a healthy diet and a sufficient amount of sleep. On the other hand, the researchers indicated that those who had poor lifestyle habits lost substantially more telomere length than the healthy lifestyle group. The study followed women 50 to 65 years old over a one-year period.
In another study, chronic stress and poor diet (high sugar and high fat) together increased metabolic risks, such as insulin resistance, oxidative stress and central obesity, more than a low-stress group eating a similar diet (9). The high-stress group was caregivers, specifically those caring for a spouse or parent with dementia. Thus, it is especially important to eat a healthy diet when under stress.
Interestingly, in terms of sleep, the Evolution of Pathways to Insomnia Cohort study shows that those who deal with stressful events directly are more likely to have good sleep quality. Using medication, alcohol or, most surprisingly, distractors to address stress all resulted in insomnia after being followed for one year (10). Cognitive intrusions or repeat thoughts about the stressor also resulted in insomnia.
Psychologists and other health care providers sometimes suggest distraction from a stressful event, such as television watching or other activities, according to the researchers. However, this study suggests that this may not help avert chronic insomnia induced by a stressful event. The most important message from this study is that how a person reacts and deals with a stressors may determine whether they suffer from insomnia.

Constant stress is something that needs to be recognized. If not addressed, it can lead to suppressed immune response or increased levels of inflammation. CRP is an example of an inflammatory biomarker that may actually increase stress. In order to address chronic stress and lower CRP, it is important to adopt a healthy lifestyle that includes sleep, exercise and diet modifications. A good lifestyle may be protective against cell aging when exposed to stressors.

References:
(1) Curr Top Behav Neurosci. 2014 Aug. 29. (2) Am J Physiol. 1991;260(6 Part 1):E927-E932. (3) JAMA Psychiatry. 2013;70:176-184. (4) Chest. 2000;118:503-508. (5) Nat Med. 2014;20:754-758. (6) Proc Natl Acad Sci U S A. 2012;109:5995-5999. (7) J Clin Endocrinol Metab. 2013;98:2078-2083. (8) Mol Psychiatry Online. 2014 July 29. (9) Psychoneuroendocrinol Online. 2014 April 12. (10) Sleep. 2014;37:1199-1208.

Dr. Dunaief is a speaker, author and local lifestyle medicine physician focusing on the integration of medicine, nutrition, fitness and stress management.  For further information, go to the website www.medicalcompassmd.com and/or consult your personal physician.

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By Bob Savage

A big crowd marched down Main Street in Port Jefferson Village on Easter Sunday, following the world’s most famous bunny to the harborfront park for an egg hunt.

Port Jefferson Easter Parade 2015
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Children scramble for candy at the Port Jefferson Easter Parade on April 5. Photo by Bob Savage
A young girl marches in her Easter bonnet at the Port Jefferson Easter Parade on April 5. Photo by Bob Savage
Participants get fancy at the Port Jefferson Easter Parade on April 5. Photo by Bob Savage
This bunny at the Port Jefferson Easter Parade on April 5 is too cool for her own good. Photo by Bob Savage
Port Jefferson Station residents Esther and Manny Monserrat, with 4-year-old son Matthew, are all smiles at the Port Jefferson Easter Parade on April 5. Photo by Bob Savage
Even dogs get in on the action at the Port Jefferson Easter Parade on April 5. Photo by Bob Savage
The Port Jefferson Easter Parade had a huge turnout on April 5. Photo by Bob Savage
Kids scramble to pick up Easter eggs at an egg hunt after the Port Jefferson Easter Parade on April 5. Photo by Bob Savage
Ireland natives Blathnaid, 6, and Tanya Hogan have a blast at the egg hunt following the Port Jefferson Easter Parade on April 5. Photo by Bob Savage
Fawn Bielello, a Mount Sinai resident, shows off her bonnet and eggs after the Port Jefferson Easter Parade on April 5. Photo by Bob Savage
Medford resident Charlotte Yee, 2, gets some eggs together after the Port Jefferson Easter Parade on April 5. Photo by Bob Savage
Ronkonkoma residents Porsha Smith, 3, Anastasia Smith, 6, Rebecca Whelen, Amanda Whelen and Kailia Smith, 8, have fun at the egg hunt after the Port Jefferson Easter Parade on April 5. Photo by Bob Savage
Bunnies pose for their mom on the sand after the Port Jefferson Easter Parade on April 5. Photo by Bob Savage
Young boys work quickly to scoop up eggs after the Port Jefferson Easter Parade on April 5. Photo by Bob Savage
Mayor Margot Garant holds Spanky the bunny for a child to see after the Port Jefferson Easter Parade on April 5. Photo by Bob Savage
A young girl runs to collect Easter eggs at a hunt following the Port Jefferson Easter Parade on April 5. Photo by Bob Savage

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John Haley photo from SBU

By Daniel Dunaief

Once they reach their destination, they wreak havoc, destroying areas critical to life. All too often, when cancer spreads, or metastasizes, through the body, it becomes fatal.

John Haley, a Research Associate Professor in the Pathology Department at Stony Brook, is trying to figure out how cancer become metastatic and, even further, what they do to avoid recognition by the immune system.

Haley is “working on the mechanisms by which metastasis occurs,” he said. He is also studying the “immune recognition of tumor cells and, in the near future, wants to link the two.”

Understanding the way metastasis works can greatly reduce mortality in cancer, Haley said. Researchers are currently attempting to develop therapies that target metastatic cells, but these are often more difficult to kill than their primary counterparts, Haley explained.

The stakes are high, as 90 percent of cancer deaths are due to complications from the spread of cancer rather than the primary tumor itself, he said.

About 80 percent of human cancers are carcinomas, which are derived from epithelial cells. Those are the cells that make up the skin, and line the stomach and intestines.

“As cancers become metastatic, those cells have the ability to shape shift,” he said.

They become much more like fibroblasts, which are underneath the skin and glue the skin to bone and make up connective tissue layers. Haley said he has made some progress in understanding the molecular mechanism that allows cells to shift from epithelial to fibroblastic cells. They have “defined factors which promote” this transition, with differences in survival and growth pathways.

Haley works with a machine called a mass spectrometer, in which he identifies proteins in complex biological samples and measures how changes in composition alters function. He spends about half his time working on his own research and the other half assisting other researchers who are seeking to get a clearer view of key changes in proteins in their work.

In his own research, he wants to understand how cancers modify a cell’s proteins. He has helped define how cancers can change their protein signaling pathways to become drug resistant, which suggests targets for drug therapies.

Haley is tapping into an area of science that many other researchers are exploring, called bioinformatics. Using statistics and mathematical models, these scientists are cutting down on the number of genes and proteins they study, honing in on the ones that have the greatest chance to cause, or prevent, changes in a cell.

“We’re taking the data sets we’ve generated and trying to predict what we should look for in human patient samples,” Haley said. “We can find a tumor cell that have mutations or this expression profile and find drugs they are sensitive to.” Once scientists find those drugs, researchers can test them in cell cultures, then in mouse models and eventually in people, he said.

“We try to isolate someone’s cancer to understand what the molecular drivers are that occur in that cancer,” Haley said. The approach, as it is much of modern medicine, is to understand the patient’s genetics and biochemistry to select for a drug that would be effective against the particular mutations present in their tumor.

A resident of Sea Cliff, Haley is married to Lesley, whom he met while he was pursuing his PhD at Melbourne University. A native Australian, Lesley was completing her Masters in Opera when the couple met at a tennis match. They still play today. Lesley has sung at New York premieres for several living composers at concert venues including Avery Fischer Hall. She teaches music at her studio in Sea Cliff. Their children share their interests. John is a freshman studying biochemistry at Stony Brook University and Emma, who is a senior at North Shore High School, plans to study science and singing.

As for his work, Haley would like to see his efforts culminate in cancer therapies and diagnostics. Any novel therapy might also become a product for a start up company which could create jobs on Long Island. “There are some fabulous scientists” at the university, he said. “A major goal of the Center for Biotechnology and Diane Fabel, its director, is to create small businesses here in New York. I’m trying to help them in that goal.”

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