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syphilis

Pregnant woman standing beside crib. METRO Creative Connection photo

By Daniel Dunaief

Cases of syphilis, a sexually-transmitted infection, have climbed dramatically on Long Island over the last decade and have continued to increase, creating a health care risk for those infected including pregnant women and their unborn children.

The number of infectious syphilis cases on Long Island quadrupled between 2011 and 2021, reflecting a national trend, Dr. Cynthia Friedman, Director of Public Health Suffolk County Department of Health Services, explained in an email, citing Centers for Disease Control and Prevention data.

“Unfortunately, case numbers continued to increase through 2022,” while 2023 numbers were not yet finalized, Friedman added.

Photo of Cynthia Friedman.

The incubation period for syphilis is between two and three weeks, with primary symptoms including painless open sores or ulcers and enlarged lymph nodes near the sore.

Left untreated, syphilis can progress through four stages, from primary, to secondary, latent and tertiary, with the last of those occurring in about 30 of cases and threatening the heart and brain and potentially causing death.

“The CDC and New York State Department of Health have issued advisories urging providers to screen their patients for syphilis when appropriate,” Friedman wrote. “Prevention of congenital syphilis is a priority.”

Indeed, pregnant women can pass along syphilis to their unborn children.

Children born with syphilis look healthy, but develop problems as they age.

“It’s a life-long debilitating disease” for infants, said Dr. Sharon Nachman, Chief of the Division of Pediatric Infectious Diseases at Stony Brook Children’s Hospital. “It affects the brain, bones, growth, teeth and every part of the body.”

Nationally, the number of children born with syphilis has also increased, with CDC data indicating that 3,700 were born with the disease in 2022, 10 times the level from 2012.

Area hospitals have been actively screening pregnant women for syphilis and, in cases where tests come back positive, have been prescribing Bicillin L-A, a form of penicillin that treats the disease and protects unborn children.

“We at Stony Brook have been very aggressive about knowing each mother’s status,” said Nachman.

At Huntington Hospital, pregnant women are also screened at least three times, on initial intake, in the middle of a pregnancy and on admission to the hospital, explained Dr. Mitchell Kramer, Chairman of the Department of Obstetrics and Gynecology.

Suffolk County runs a Congenital Syphilis Prevention Program, which follows women who test positive for the infection during their pregnancy to ensure they are adequately treated and that their infants receive appropriate monitoring and follow up, Friedman wrote in an email.

Still, infections occur among newborns in the county.

“There are generally a few babies born with congenital syphilis in Suffolk County each year,” explained Friedman. “This usually occurs when mothers have had no or limited prenatal care.”

Supply of medicine

Hospitals have been extremely careful with their supply of Bicillin L-A, which is the most effective and safest treatment for pregnant women who aren’t allergic to penicillin.

“Across our institution, nobody could touch those [treatments] unless they were treating a pregnant woman,” said Nachman.

Pfizer, which manufactures the drug, indicated in June that they have enough Bicillin to treat diagnosed cases of the disease.

Kramer said the earlier supply limitations of Bicillin L-A hadn’t been an issue in his practice, although he “wouldn’t be surprised if smaller health care facilities had a shortage.”

Causes of the increase

Health care professionals suggested several possible causes of the rise in syphilis.

An improvement in the prevention and treatment of HIV, the virus that causes AIDS, has likely led to a reduction in the use of condoms, which help prevent the spread of sexually transmitted infections.

An increase in the use of apps to find potential partners may also have increased the spread of these infections, said Nachman.

Additionally, some people may feel there is a “stigma associated with STIs” and may be reluctant to go to a doctor and ask for a test, said Kramer.

Numerous states have lost funding for STI prevention, which also likely reduced the awareness of the need for people to protect themselves, Kramer added.

Populations where there’s disparities in health services and that don’t have access to screening and treatment are “health care deserts” as patients “are not getting proper care and screening,” Kramer said.

Syphilis isn’t just a problem for any one age group.

The infection has been making the rounds at senior centers and assisted living facilities, with cases rising among people over 65 years old. Seniors who aren’t concerned about pregnancy can be at risk for contracting a sexually transmitted disease.

Area hospitals have been urging residents to understand the prevalence and health consequences of STIs and have urged people to protect themselves from the disease.

“There is a concerted effort to get the message out,” Kramer said.

Pixabay photo

Amid an increase in adult and congenital infections, the Suffolk County Department of Health Services is urging pregnant mothers to get tested for syphilis.

Untested and untreated, infants born with the congenital bacteria can appear normal and healthy but can encounter developmental delays and health challenges later in their lives.

The county recommends that pregnant women get tested for syphilis at their first prenatal visit, at the beginning of their third trimester and again at delivery.

“Syphilis during pregnancy is easily cured with the right antibiotics,” Mary Pat Boyle, bureau chief for the Suffolk County STI Control Unit and member of the New York State Congenital Syphilis Elimination Strategic Planning Group, said in an email.

Pregnant New Yorkers can qualify for Medicaid at higher income levels. Uninsured pregnant residents may quality for a Special Enrollment Period to enroll in private health insurance through the NY State of Health Marketplace.

The county recognizes that “barriers to testing and treatment do exist,” Boyle said. “The county staff is aware that patients turning to urgent care for support find that the centers don’t treat syphilis and are referred to another provider causing delays in their treatment.”

At the same time, staff at Suffolk County, which has been social messaging about STIs during STI Awareness Week, has confronted issues with insurance companies that don’t cover benzathine penicillin G 2.4 million units, the medication needed in one to three doses as recommended by the Centers for Disease Control and Prevention and the only treatment safe for pregnant women.

Suffolk County Department of Health Services brought this to the attention of NYSDOH, which is “looking into the matter,” according to county officials.

The incidence of syphilis for the population of the country has climbed dramatically. A report from the CDC showed that the number of cases of syphilis rose 32% to over 176,000 in 2021 from the prior year.

In New York State, pregnant persons with reported syphilis increased by 51% in 2020 to 53 from 35 in 2016.

In July 2022, Suffolk County’s Board of Sexually Transmitted Disease staff launched the Suffolk County Congenital Syphilis Prevention Initiative.

“The groups have been raising awareness of increased cases of maternal and congenital syphilis among those who work with at-risk women of childbearing age and mobilizing to implement evidence-based practices to prevent congenital syphilis,” Boyle said.

The bureau staff has visited over 167 Suffolk County OB/GYN providers to discuss best practices and distribute educational materials emphasizing the importance of STI testing and timely treatment.

The county’s STI unit is planning training for team members at St. Catherine of Siena Hospital, Southampton Hospital, Stony Brook University Hospital and Planned Parenthood Hudson Peconic.

Dr. Sharon Nachman, chief of the Division of Pediatric Infectious Diseases at Stony Brook Children’s Hospital, noted the increase in congenital syphilis and suggested that newborns don’t necessarily show clear signs of the infection.

“You sometimes don’t know until perhaps years later, when the baby is not growing, thriving and meeting developmental milestones” that it has syphilis, Nachman said. “There are no abnormal blood tests. The baby looks fine.”

Nachman said that parents and doctors don’t want to “be in a position where you’re picking it up late” because untreated and untested syphilis could have a “lifelong” effect on the growing child.

Nachman added that testing for syphilis in newborns often involves a spinal tap, in which doctors take a small amount of fluid through a spinal tap. Spinal tap procedures in newborns can involve pain and tenderness, but do not generally present risks to the developing child.

Penicillin shortage

At the same time, the supply of penicillin could become a concern. As a generic drug, the profitability of penicillin has decreased dramatically.

The injectable form of penicillin, which is used to treat syphilis, may become a problem later this year and will “definitely be a problem next year and afterwards,” Nachman said.

Researchers are checking to see if there are other drugs, they can fine tune instead of penicillin. They are exploring whether they can convert other therapies that are short acting into longer acting treatments.

“Everyone is aware of the question and [researchers] are carving out different ways to answer” it, Nachman said.

If the county uncovers a shortage of syphilis treatment, it will work with the New York State Department of Health to address the problem, county health department officials said.

For adults, Nachman suggested that seeing an increase in syphilis among newborns suggest that the bacteria may be prevalent in the community.

“When I see an uptick in neonates, I think, ‘Oh, gosh, there are more adults out there’” with this infection, she said.