Authors Posts by Daniel Dunaief

Daniel Dunaief

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Midterms are nothing short of a mental battlefield. Our sleep-deprived children step out of the house, their hoodies raised over their ears like helmets, covering hair they didn’t have time to comb while also keeping inside their overburdened heads the Latin words for “seize the day.”

They clutch their swords — their No. 2 pencils and erasable pens; and grasp their tiny shields — the one-page sheets filled with the equations for photosynthesis and the description of the domain Archaea.

When the kids arrive at school, they don’t look left and right because they don’t have much time to chat with friends, avoid enemies or wonder what fashion statement the popular students are making. They are bracing for battle and they have to climb the mountain in front of them without allowing too many mistakes to slow them down.

We adults have been through these moments before, just as we have had shots, skinned our knees and struck out in a big game. And yet watching our kids go through all these challenges brings a whole new level of anxiety, butterflies and, like Pandora’s box, rays of hope. Might this be the time when they succeed just as they feel they are about to succumb? Could this be just the confidence boost they need to help them relax and attack these tests with the equivalent of the light side of the force on future tests?

While the kids write about epiphanies, rarely, as those of us who have gone through this know, do they happen in the middle of an exam. Sure, there might be a moment when they say, “Oh, right, of course, I know this. The answer is ‘0’ because it can’t be anything else.” But more often, even if they figure that one out, they still have another six pages of mysterious questions, such as “What king believed in absolutism?” [Louis XIV of France]; and how did Dante know what my world would be like on test day when he wrote “The Divine Comedy”?

There are all kinds of lessons that await them, some of which apply to the material itself, while others relate to the best test-taking strategy. I recall a test many years ago in which the teacher urged everyone to read all the instructions first before starting. Few of the students did that because they didn’t want to lose time and because any sound outside their heads competed with the pneumonics they were repeating inside their brains like lines in a play.

As the tests arrive on their desks, their legs might start shaking involuntarily, trying to get their minds moving, the way Olympic runners take short, quick jogs before crouching down in the starting blocks. They go through whatever lucky rituals they might have, thinking about the words of a friend or relative, taking a few deep breaths or looking up at the clock, knowing that — one way or another — the hands that slowly circumnavigate those 12 numbers all day, every day, will move them toward their uncertain future.

Maybe they chuckle to themselves at the higher dose of perfume than normal from the girl to their right or the stronger scent of Axe deodorant from the boy to their left. Maybe these other students didn’t take showers that morning because they got up too late or because they sat on the edge of their beds cramming through those last few facts.

Few of them will emerge from the battle completely unscathed. Hopefully, next time around, they’ll remember their earlier wounds and will learn how to avoid making the same mistakes. That, in any context, constitutes progress.

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Steven Strogatz picked up the phone to hear the familiar voice of someone he’d never met.

“I got a call from out of the blue, which was really shocking,” said Strogatz, a math professor at Cornell University. “He said, ‘this is Alan Alda. I don’t know if you know me, but I’m an actor.’”

Alda had read an article Strogatz wrote for Scientific American about synchronization in the natural world, which included phenomena like thousands of male fireflies flashing in unison like a Christmas tree. Alda said he wanted to discuss the article.

The Manhattan-born actor visited Strogatz, who was then at MIT in Massachusetts.

“He was this super-famous TV and movie actor,” Strogatz said. “He was not particularly well-known for work in science communication, like he is now.”

At the time of his call to Strogatz, which was more than 20 years ago, Alda was only one year into hosting the PBS series Scientific American Frontiers, in which he wound up interviewing hundreds of scientists during the 11 years he hosted the program.

Alda, who is turning 80 on the Thursday this newspaper comes out, has developed a second career as a science communicator, winning a star-studded list of new fans who appreciate his passion, intellect and, most of all, thirst for knowledge that has turned this seven-time Emmy winning actor into a champion of scientific knowledge and scientists.

Alda is “phenomenal,” said Eric Kandel, the director of the Kavli Institute for Brain Science at Columbia University. Kandel explained that Alda and a talented Norwegian journalist have been the master of ceremonies for the Kavli Prizes, which are given out in Oslo, Norway, every two years to researchers in astrophysics, nanotechnology and neuroscience.

The prestigious Kavli awards are modeled after the Nobel Prize. Kandel, 86, knows a thing or two about those awards as well: he shared the Nobel Prize in 2000 in Physiology or Medicine.

Alda has helped teach Kandel about the communication of science. Alda’s “range is quite broad and his ability to communicate is quite remarkable,” Kandel said.

Kandel attended an 80th birthday bash for Alda a few weeks ago. He took a turn talking to those celebrating an extraordinary life.

“What had been emphasized by the family was his acting career,” Kandel said. He described two important features about Alda.

First, “He’s revolutionized the communication of science to the public. He’s made an enormous impact. He does not have a peer.” And second, “He’s the most unpretentious guy you’ve ever met. You’d never have thought he’d done a movie.”

In 2006, the unpretentious Alda approached Shirley Kenny, the former president of Stony Brook University, about starting a center that would help scientists share their goals, approaches, and results with the public.

Alda met with several people in East Hampton, including Howard Schneider, the dean of Stony Brook’s journalism school.

“The creation story” that explains the origins of the Center for Communicating Science, “starts with this porch meeting,” Schneider said.

When the group returned from East Hampton, they discovered that there were occasional programs and courses and workshops about communicating science, but there didn’t appear to be any center devoted exclusively to “improving the ability of scientists to communicate with the public,” Schneider said.

Aided by former U.S. Rep. Tim Bishop and current U.S. Rep. Steve Israel (D-Huntington), Stony Brook applied for, and received, a federal grant of $220,000 to start the effort.

Alda “was the inspiration and remains the inspirational figure in this effort,” Schneider said.

The seed money led to the founding in 2009 of the Center for Communicating Science, offering students an opportunity to learn how to connect with a range of audiences through various types of training, including improvisational acting, which is the only training Alda received.

Improv requires people to listen to what other people are saying and build off of that, forging connections through shared common ground, Schneider said.

“One rule of improv is that you say, ‘Yes and,’” said Elizabeth Bass, a founding director at the center. “You have to take what [the other person] gives you and add to it.”

Valeri Lantz-Gefroh, the improvisation director at the center, came from the world of theater to the center. She said Alda helped her learn more about a “skill I’ve been working on for 30 years by teaching it in a different way. That gift has come from Alda.”

Indeed, scientists who have taken these courses suggested that they have been invaluable in helping them deliver their message and connect with their audience.

Colin West, a research assistant at the C.N. Yang Institute for Theoretical Physics at Stony Brook, took six courses at the center. Before he attended the classes, he said he was introverted.

“It’s not enough to eschew the jargon from my own vocabulary,” West said. “I should be trying to understand the jargon and phraseology that’s typical in their patterns of thought and incorporate them into my language.”

Alda has also helped a wide range of scientists. He has “made many of us look from the outside at what we do and ask how we can do better in telling our stories and be more engaging about our fields,” said Louise Leakey, a research professor in the department of anthropology at Stony Brook who works on human evolution in Africa.

Alda asked Leakey to sit on the advisory board at the center because she was working to make the fossil collection accessible online and set up a citizen science project in paleontology.

The notion of sharing science with non-scientists has only recently become more acceptable and more popular, in part because scientists are struggling to get funding for projects ranging from basic science exploring physical properties at an incredibly small scale to discoveries that might help treat diseases like cancer, Alzheimer’s disease or schizophrenia, researchers said.

Alda has continued to be a driving force at the center, which, in 2013, was renamed the Alan Alda Center for Communicating Science. In what friends suggest was typical self-deprecating fashion, Alda said he was flattered that the school was named after him and suggested that, to that point, only a horse had shared his name.

Committed to the center and passionate about science, Alda continues to keep a schedule that would exhaust someone half his age. Years ago, he shot his final episode of The Blacklist, in which his character, Alan Fitch, dies.

That night, Alda flew to Chicago to give a talk as the keynote speaker of the American Association of Medical Colleges to an audience of more than 1,200. Alda didn’t get his wake up call and got up 20 minutes before his 8 a.m. speech, when he inspired leaders about the need to share science with the public.

That night, Alda flew back to New York, where he opened on Broadway in a matinee of “Love Letters.”

Bass said Alda’s work ethic has inspired others at the center.

“We want to help” these efforts become “an important part of his legacy,” Bass said.

It’s a legacy that continues because of a lifesaving surgery Alda had when he was meeting with a scientist in Chile in 2003.

When a local surgeon made a diagnosis and told him the procedure, Alda said he’d need an end-to-end anastomosis. The surprised surgeon asked him how he knew that, and Alda said he used to pretend to perform that in the show “M*A*S*H.”

Friends, colleagues, and scientists appreciate the active intellectual life Alda and Arlene Alda, who have been married close to 59 years, share.

Arlene Alda, a photographer and children’s book author, and her husband have numerous books in their house, Strogatz said. They use these books to continue to feed their curiosity. Alda has also asked Strogatz to give him geometry problems to solve.

“He works on them with great effort for weeks or months at a time,” Strogatz said.

For Alda, the final product, however, is less important than the process. And that process continues as Alda heads into another decade.

These days, the people who imagine his distinctive voice aren’t picturing Hawkeye Pierce in a red robe running to a helicopter so much as they are looking for inspiration in their efforts to share the wonder and beauty of science.

“Sometimes when I have to explain a complicated topic to a nonscientist, I imagine Alan sitting next to me and asking me questions like I’m a guest on Scientific American Frontiers,” West said. “Trying to envision what questions he would ask often helps me figure out what answers to give.”

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Above, algae growing in plastic grids in Ian Blaby’s lab. Photo from Blaby

This is the second of a two-part series on Brookhaven National Laboratory’s Crysten and Ian Blaby.

While his wife is something of a metal worker, Ian Blaby is much more of a farmer. He cultivates rows upon rows of an unusual crop under numerous different conditions to see how they’ll grow and respond.

Like his wife Crysten Blaby, the organism he studies is a single-celled algae, which means those rows upon rows of crops can fit on the top of a bench, instead of dotting an expansive green field in the middle of the country.

Ian Blaby, who was born in Torquay, England, and earned his Ph.D. at Cambridge University, wants to know what genes are involved in carbon metabolism as the power algal couple look to unlock some important genetic secrets. The algae they study, Chlamydomonas reinhardtii, has 17,741 genes.

“We have a good idea what 5 to 10 percent of those genes are doing when it comes to the functioning of the cell,” Blaby said. Scientists have a vague idea for about another 40 percent, which means that about half of those genes are unknown. His goal is to figure out how the products of those genes, proteins, interact with each other.

Understanding these genes can translate into a better awareness of similar genes in more complex and diverse organisms, such as food and biofuel crops, Blaby said. The overlap and the potential for unlocking important genetic codes for more complex plants has led the Department of Energy to designate the alga a flagship species.

“It has been recognized as having a lot of potential,” Blaby said. He estimates there are about 100 labs around the world that are studying it.

John Shanklin, the head of the plant sciences group at BNL, likened the understanding of the genes of the algae to seeing the skyline of a city from a distance. While the view might provide information about where the buildings are, it doesn’t reveal much about what’s inside them. The information Ian and Crysten Blaby collect can provide greater insights about the genetic inner workings of this algae.

Additionally, Shanklin said medical researchers have been able to take studies done with yeast and apply them to human diseases. The similarities between algae and plants are two- to fourfold higher than they are between yeast and humans.

Discovering gene functions is “one of the, if not the, biggest problems in biology,” Blaby said. “Many, many labs around the world are tasked with addressing this. My approaches are not unique, but certainly very specialized.”

Indeed, using plastic grids that allow individual conditions in 384 small squares, Blaby can see how the alga grow and survive under a host of conditions, all at the same time. Blaby uses hundreds of these plates in any one experiment. He compares different strains under the same conditions of light, temperature or composition of the growth medium, or compares the same strains under different conditions.

Screening all those small squares would be laborious work and would invite human error.

“By the time we might be looking at plate 177, human error could creep in,” Blaby said. Instead, he uses robots to transfer the plates from incubators to readers. He gets real time information on how every strain is behaving under each condition.

When Blaby finds a plate where the growth is conspicuously different from the parent alga, he can go back and screen for the genetic differences. This can help him focus in on a particular genetic sequence.

“A different behavior can be assigned to a gene, or region of DNA, providing clues to a specific function which can then be followed up using other methods,” Blaby explained. This would be considerably harder and more difficult with crop plants that have more genes and a considerably longer time to produce the next generation.

Crop plants present numerous complications, including the time to grow, the space requirements, and the challenge of growing them under carefully controlled conditions, in addition to the different genes for roots and leaves, expressed in different cells.

For the algae, the doubling time is about eight hours, which means that this algae can be handled in a lab in a way that’s similar to bacteria.

Blaby’s interest in carbon metabolism stems from his post-doctoral work in Los Angeles.

“Carbon forms the basis of biofuel,” he said. He hopes to identify “novel genes that are involved in fuel production but that weren’t known.”

While scientists like Crysten and Ian Blaby are studying single-celled algae in their lab, they have the big picture goal of the application and translation of their work to a real-world problem and limitation that will affect future generations of people.

“We’re making more people, but we don’t have more land area for growing crops,” Shanklin said. “The only options are to grow crops” on currently unused land or to “make the growth more efficient. We’re working on both sides.”

The BNL department has a mandate, along with other researchers working with the DOE, to “make plants more efficient. We can’t do that if we don’t know what the genetic parts are of the plants” that are important for survival in different conditions, Shanklin added.

In addition to hiring Ian and Crysten Blaby and Qun Liu this fall, BNL is in the process of working with the DOE on long-term planning. “We’re looking at how big this program can become,” Shanklin said. He is excited about the work Ian and Crysten Blaby are doing. “It’s not enough to work hard,” he said. “You have to identify big problems and work on those. The problems they are addressing are ones that are holding back whole elements of science.”

Shanklin sees Ian and Crysten Blaby as contributing more together than the sum of their research parts. “They are both independently excellent scientists who have different but complementary skill sets,” he added.

This version corrects the name of the type of algae Ian Blaby is studying and the town in England where he is from.

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The team moves as a unit, wearing the same clothes, often with the same hairstyles and even, on occasion, with the same walk or swagger.

They laugh together, lean on each other, share embraces and confess their inadequacies.

“I was terrible,” one of them said, while she took a restorative homemade brownie from a friend.

“You’ll get ’em next game,” her friend suggested. “We’re back on in 15 minutes.”

We took our daughter to a regional volleyball competition in Pennsylvania recently, where teenagers from all over the area trekked in packed cars to bump, set and spike together.

The weekend presented an opportunity for our children to play a sport they love, while it was also a chance for parents to squirm, squeal and celebrate alongside them.

The younger generation exuded joy and confidence. After every point in teenage volleyball, the girls cheer, offer a quick huddle and then return to their positions on the floor.

Our team developed its own ritual after long points in which it emerged victorious. The players all jumped straight up in the air, then met in the middle of the floor to celebrate the hard-won point.

When they’re not on a volleyball court, these children mostly move around individually, even if they can stay in touch with friends and family on their phones and through social media. They don’t take tests together, they don’t study together — most of the time — and they don’t have a common goal. Sure, they might all wish each other the best but, ultimately, they learn on their own and succeed individually.

Modern team sports which, admittedly, take an extreme commitment of time and money, have also created opportunities to make memories, to grow together and, for the moment at least, to share a goal that is bigger than any one person.

That, of course, isn’t limited to sports. That can be true of a music group where everyone creates the kind of live performance that reverberates in audiences’ minds long after the instruments are put back in their cases and the musicians return to their homes and their homework.

The unbridled and shared joy in the moment is akin to witnessing the flames of a dancing campfire high in the mountains on a starlit night. During these matches there are no tests, no boyfriends, no worries about college, no concerns about acne, no wardrobe misfires and no helicopter parents. There is only the euphoria of the moment, the ecstasy that comes from pulling together and going toe-to-toe with another team and, at least in that second and for that point, emerging victorious. It’s not even about winning the gold medal or even a match.

My daughter’s team defeated one of its opponents easily, winning two games by a wide margin. The other team, however, won several exciting points and, despite the lopsided score and the unbalanced skill sets, celebrated every point with the same energy as if it had achieved something remarkable. And who’s to say it didn’t? The games presented ample opportunities for victories that were independent of the final scores.

Parents were as emotionally spent after exciting matches as their children, as they cheered, clapped, pranced nervously along the sidelines, and hooped and hollered. They basked in their children’s successes and encouraged them to find a way to triumph, where the margin of victory often seemed to reflect perseverance and determination as much as it did genuine skills.

In our lives, we have become so focused on our goals for tomorrow and plans for our future journey that we don’t always get to stand up and celebrate the moment. All weekend, mothers, fathers, sisters, brothers and a community of new friends celebrated a common goal of finding and sharing the best in each other.

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Crysten and Ian Blaby. Photo by Kevin Keck

Part 1 of a two-part series.

She is a “creative thinker,” while he is a “fearless experimentalist,” according to UCLA Distinguished Professor Sabeeha Merchant. Brookhaven National Laboratory recently hired the tandem of Crysten and Ian Blaby in the Biology Department.

Crysten and Ian Blaby did their postdoctoral work in Merchant’s lab for about five years. Merchant believes “there is no question that they will make discoveries to advance knowledge.”

The Times Beacon Record Newspapers will profile the scientific studies of the Blabys. This week’s column will highlight the work of Crysten Blaby, and next week’s will profile Ian Blaby.

Crysten Blaby is something of a metal worker, although she doesn’t dig anything out of the earth, wear a hard hat or ship metals by the ton. In fact, the amount of metal in her job is so small that the copper, iron, zinc and manganese she works with in a year wouldn’t fill a teaspoon.

That’s because Blaby (pronounced like “baby” with an extra letter) studies a one-celled algae called Chlamydomonas reinhardtii. This organism survives in a wide range of environments, where the amount of available metals can be precariously low, dangerously high, or can bounce back and forth between extremes.

Blaby, who is an assistant biologist at BNL, would like to know which proteins in these algae, among other species, including bacteria, plants and animals, are involved in maintaining a balance of metals.

“I am focused on the genes and proteins in metal homeostasis,” she said. That means she wants to know what genes are active in different environments.

Understanding the molecular biology of algae can provide clues about where to look for similar genes in more complex members of the plant kingdom. Discovering these processes could help farmers develop techniques that will foster growth for biofuel crops that are cultivated on lands that are less suited for food production.

“With this research, we could find easy, cheap ways to ‘diagnose’ whether crops are deficient in metal nutrients and best know how to remedy it,” she explained. “This research could also be used to help select which crops or breeds would thrive best given the quality of a particular soil.”

While Blaby won’t help produce new biofuel crops, her discoveries about the genes involved in metal homeostasis is part of “foundational science” that will underpin those types of discoveries, said John Shanklin, the head of plant science research at BNL. “Without [Ian and Crysten Blaby] doing this” the scientists who want to produce biofuel crops in inhospitable environments “are stuck.”

Blaby’s work could also help provide information that might translate into therapies for human conditions.

Menkes disease and Wilson’s disease are two inherited disorders of copper metabolism, which are caused by dysfunctional copper transporters, she said.

Blaby recently discovered a copper chaperone that looks similar to a molecule in humans and that’s involved in keeping algae safe from accumulations of copper. She suggested that the chaperone in algae protects the cell from copper by making sure that it is hand delivered between proteins. More research, however, is needed to ensure this model is accurate.

Blaby is studying the biochemical routes these metals take into the cell. The main gatekeepers controlling the movement of metal ions across membranes are likely transporters, she said.

Blaby is scheduled for beamline time at the new National Synchrotron Light Source II facility at BNL this April. The process of getting time on the beamline is extremely competitive, with numerous top-notch scientific projects rejected in part because the facility can’t yet meet the demand for a light source that is 10,000 times more powerful than the original synchrotron.

“People recognize [Crysten and Ian Blaby] are asking cutting-edge questions and they are trying to assist them in every way they can,” Shanklin said. “Everyone wants to be a part of [their] success.” After she moved to BNL, Blaby developed her NSLS-II application with Professor Emeritus Keith Jones, a physicist who she said is involved in experiments at the new synchrotron, and several of his collaborators.

“The goal is to uncover where metals travel in the cell after uptake and before they are loaded into target proteins, and understand which proteins, such as transporters, are involved” in this process, she said.

Blaby is collaborating with Qun Liu, another new hire at BNL, to look at transporter proteins, to understand how many different kinds there are, and “figure out how plants move nutrients around,” Shanklin said.

One of the ways she can solve how genes respond to different environments is by using small RNAs to knock down gene expression.

Ian and Crysten, who met when they worked in a lab in Florida, are residents of Miller Place. When they met, they were “instantly friends,” she said, in part because of their shared interest in science. They each appreciate having someone who “understands the challenges, disappointments and pure joy of discovery that comes with pursuing this career.”

The plant biologists have a two-year old daughter Emily.

As for their work, Crysten Blaby said they collaborate with each other but also concentrate on those areas where they have each developed their individual skills.

“We focus on the pathways for genes that are involved in processes that we have expertise in and where our passion lies,” she said.

This version corrects the department Crysten and Ian Blaby work in at Brookhaven National Laboratory.

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Rainbow over NSLS-II: Brookhaven National Laboratory’s National Synchrotron Light Source II is a state-of-the-art 3-GeV electron storage ring. Photo from BNL

They built something that makes Superman’s x-ray vision seem antiquated by comparison. Many of them have dedicated as much as a decade of their lives to constructing a cutting-edge technology that will help researchers around the world see small, rapid processes as they are happening.

As 2016 begins, scientists from around the world are heading to Brookhaven National Laboratory in Upton to look closely at processes and atomic configurations at the National Synchrotron Light Source II, a $912 million scientific facility completed last year. At the same time, those involved in constructing this project plan to continue to add beamlines.

The project originally came in under budget and ahead of schedule, allowing BNL to expand the size of the ring building, which improves the performance from the instruments, among other enhancements.

“In principal, at least in a peripheral way, if it involves analysis of the structure and function of materials, there is nothing beyond the reach of a facility like NSLS-II,” said Erik Johnson, who has held a variety of positions at NSLS-II from accelerator interface manager to finishing as the deputy project director.

“This is not only an increase in quantity but on quality” of information,” said Ferdinand Willeke, who came to BNL in 2007 as the head of the Accelerator Division, which built and operates the magnet storage ring. “In an extreme case, data are collected 10,000 times faster.” Willeke said the process involved a seven-layer structure with about 30,000 activities.

“The project was more a marathon than a sprint, but, as in each large project, there are issues to resolve to keep everything proceeding smoothly,” Willeke said. “This required enormous commitment from the entire staff” who routinely went the extra mile “from the start to the end.”

Those who worked on the project credited a large team of people for helping to complete the NSLS-II. That includes Steven Dierker, who was the project director, Marty Fallier, who was the Facilities Division director during the design and construction, Diane Hatton, who was the business manager, and John Hill, Qun Shen and Paul Zschack, who were, at various times, in charge of the beamlines. Satoshi Ozaki served as senior project advisor. Samuel Krinsky “was a prominent accelerator scientist who had a large influence on NSLS-II accelerator layout in the pre-project phase,” Willeke said. Krinsky passed away last year.

The project itself included hundreds of workers in various stages, while leaders from different groups routinely met in person or sent emails back and forth during weekends, vacations or personal time, ensuring that the process stayed on target and under budget. “I’ve invested 10 or 15 years of my life to bring this to reality,” said Johnson.

So far, the reviews from the beamlines that have gone live have been encouraging. “The performance of the accelerator itself is a dream,” said Elaine DiMasi, a physicist in the Photon Sciences Division at BNL. “According to all reports, its stability and brightness are every bit as good as what was theoretically planned.”

As a facility funded by the Department of Energy, the NSLS-II can uncover undocumented details about batteries while they are in use. Indeed, scientists can place batteries in front of the beamline and determine exactly what happens as they discharge, potentially leading to a more effective design of future batteries and energy storage devices.

“Imagine all the material things you could do with the capabilities we have here, in trying to improve energy efficiency or energy conversion,” Johnson said. “In my view, next to food security, [energy security] is at the top of the geopolitical issues that shape the world.”

Johnson is interested in seeing what the NSLS-II can reveal about catalytic reactions and chemical pathways. In some biochemical reactions, catalysts help speed up or direct processes. Along the way, however, some intermediate steps are far preferable to others, which might slow a reaction.

“When you have a chemical reaction, you may want this [molecule or intermediate step] and not the other six,” Johnson said. The NSLS-II will allow scientists to focus on what they can do to the catalyst to encourage one particular step. “You may wind up making configuration changes to the way the molecules are absorbed on the working catalyst surface so some chemical pathways are more favored than others. There’s a whole gamut you can look at now that you couldn’t [see] before.”

While the team who made the NSLS-II a reality is pleased with what it can do, they realize there’s still considerable work ahead. “We are still in the process of bringing this machine to full performance,” said Willeke.

DiMasi said those who are building the second, third and fourth waves of beamlines are “sprinting to complete our tasks and help make the full build-out a reality.”

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He started, “Once upon a time, three little brown bears.”

“No, no, that’s not right!” she shouted, interrupting him before he could get to the action. “They weren’t little, there weren’t three of them and they weren’t brown.”

“Wait!” he protested, putting up a finger. “Who is telling this story, you or me?”

“No, well, if you’re going to tell it, tell it right,” she argued.

“But it’s a children’s story,” he snapped. “Can’t we just tell the story?”

“You want him to go to school with the wrong details? You want him to come home with a bloody nose because someone punched him when he argued about whether they were little brown bears or medium-sized, endangered polar bears?”

“You think our kid is going to get into a fight because I might have used the wrong details in a story? Weren’t we trying to put the kid to sleep? Look at him now. He’s crawling all over the bed, putting everything he can reach into his mouth,” he said.

“Yeah, well, get the details right next time,” she huffed, storming out of the room.

What is it about storytelling that divides the sexes? Why is it that a man remembers a story one way and a woman seems so much better at remembering the details?

Is it fair to generalize? Well, like every generalization, yes and no.

A friend recently shared his observation that his girlfriend, whom he thinks is absolutely one of the best people he’s ever known, has only one small problem — she tends to take all the momentum out of his stories by correcting him.

Is she wrong, I wondered? And even if she’s not wrong, do the details matter? When I thought about all the couples I’ve known over the years, it seemed to me, in my nonscientific recollections, that the women were more likely than the men to halt a story to fix a detail.

“So, there were we were, in the middle of a fire alarm scare in Boston, and we were standing at the window ledge, eight stories up,” he might be saying.

“No! No! We were in San Francisco, not Boston, and we were on the 11th floor,” she might suggest.

A glare and bad body language often follows, as the man loses the thread of his story while he grinds his teeth, wondering whether he can or should confront the love of his life in front of other people.

Is this one of those differences between the sexes that reflect the fact that men are from Mars and women are from Venus? I suspect it is. The way I see it, the details we share about our lives in stories are like the fish we might collect if we were standing at the edge of a pier in Stony Brook, dropping nets into the water to catch fish — or story details — as they swim by.

The holes in a man’s net are larger, letting the small fish swim through, while the holes in the women’s nets are smaller. The women pull up their nets and notice and count the large and small fish, paying meticulous attention to everything, cataloging the variety of fish in their nets.

The men look at the fish and wonder: (a) “Is this enough for dinner?” (b) “Should I take a picture of it?” and most importantly (c) “Did I catch more fish than my brother or the stranger at the end of the pier who kept bragging about all the fish he caught?”

The next time a man’s story goes off track because of specific details, maybe he can suggest he’s focusing on the “bigger fish.” Then again, a woman might rightfully reply that he’s just telling another “fish” story.

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Skeleton racer nabs first place in 2016 IBSF World Cup race in Lake Placid

Annie O'Shea, of Port Jefferson Station, practiced for the World Cup skeleton race in Lake Placid, NY earlier this week. O'Shea won her first World Cup gold medal in the event on Jan. 8 Photo by Pat Hendrick

On her home track in Lake Placid, Port Jefferson Station’s Annie O’Shea won her first gold medal in a World Cup skeleton race.

O’Shea scored a combined time of 1 minute, 50.34 seconds, beating out Switzerland’s Marina Gilardoni by 0.09 seconds for the top spot. O’Shea slid down the track in a time of 55.26 seconds in her first heat, which was good enough for third place, a tenth of a second behind the leaders. She followed that up with a time of 55.08 seconds in her second run, tying a track record.

Annie O'Shea, who graduated from Comsewogue, recently won her first World Cup gold medal in a skeleton race in Lake Placid, NY. Photo from the USA Bobsled and Skeleton Federation.
Annie O’Shea, who graduated from Comsewogue, recently won her first World Cup gold medal in a skeleton race in Lake Placid, NY. Photo from the USA Bobsled and Skeleton Federation.

“I wanted this for so long,” O’Shea said. “Everything I’ve done these past 10 year — to become better and work on myself and the process, has paid off.”

After her second run at the 2016 International Bobsleigh & Skeleton Federation World Cup event on Jan. 8, O’Shea stood at the bottom of the mountain watching as the only two racers who could beat her time took their turns. When she saw that she’d won, her jaw dropped as she leaped in the air before hugging her assistant scouting coach, Zach Lund.

“I started crying at the bottom and I couldn’t stop,” she said. After the awards ceremony, O’Shea stopped to sign autographs for young fans.

The Port Jefferson Station athlete, who graduated from Comsewogue and was a 2004 outdoor track and field state champion in the pentathlon when she attended SUNY Plattsburgh, had been ranked 11th in the world coming into this World Cup event in Lake Placid, which is home to the “Miracle on Ice” USA men’s ice hockey team that won a gold medal in the 1980 Winter Olympics.

O’Shea said she appreciates the consistent support from her family, friends and community.

“It’s nice to feel when you go home that people kind of have a place for you or are cheering for you,” she said.

O’Shea had previously won a silver medal in December of 2011 in La Plagne, France. This, however, is her first gold at this level of competition.

Tuffy Latour, the head coach of the skeleton team, said O’Shea has been building towards this moment for several years, and has come on strong this year.

“Her potential [has been] through the roof,” Latour said. “It was kind of story book for her. She [was in] third and then put down a very fast heat.”

Port Jefferson Station's Annie O'Shea, center, claimed a first-place finish behind Marina Gilardoni from Switzerland, left, and Laura Deas from Great Britain, right, in the World Cup skeleton race in Lake Placid, NY. Photo from Amanda Bird
Port Jefferson Station’s Annie O’Shea, center, claimed a first-place finish behind Marina Gilardoni from Switzerland, left, and Laura Deas from Great Britain, right, in the World Cup skeleton race in Lake Placid, NY. Photo from Amanda Bird

Her mother, Linda, watched the race at her desk in the Comsewogue School District’s district office. She said she jumped out of her seat and cheered with one of her colleagues who watched the finish with her, drawing a crowd of people to her desk, who were quick to share I the excitement.

“I’m so proud of her,” Linda O’Shea said. “It’s the perfect start to a new year.”

Competitors in skeleton use the same curved ice track as racers in luge and bobsled. Bent over and holding onto the sides of their sleds, they sprint for five to six seconds, then dive headfirst onto their sleds. Clad in aerodynamic suits, they slide down the track at speeds of over 80 miles per hour, banking through turns with slight shifts of their body weight.

The next World Cup skeleton race will take place in Park City, Utah on Jan. 15th and 16th. The World Cup races are the second-largest events in the sport behind the Olympics. The skeleton team is currently preparing for the 2018 games in PyeongChang, South Korea.

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When the Wright brothers invented man-made flight more than a century ago, I can’t imagine they thought it’d be a good idea for airlines to charge for meals when more than 200 people are stuck in the same plane for over four hours. Then again, they may not have imagined just how common and popular planes would be.

Almost anywhere in the country, we can look toward the heaven and see a plane bathed in sunlight at the end of the day.

Then again, someone on that plane might have just closed the blind, keeping that annoying light off the screen to watch a fictional character stuck on Mars, colonizing a planet with potatoes.

Speaking of uncomfortable situations, maybe the guy or girl stuck in the last row near the bathroom is rooted near someone who insists on sharing his life story, his experience with his neighbors, or his laundry list of gripes. If the Long Island Rail Road can make quiet cars, can airlines designate quiet sections? Maybe they can add a quiet button, with a picture of a flight attendant with a finger over her pursed lips on the bulkhead?

The flight attendant might whisper, “As you can see, the captain has turned on the ‘No-sharing terrible stories, petty frustrations, or things you might find funny with the person next to you button.’ Please, zip it! While you’re at it, please stop tapping that person on the shoulder to get him to look at you. He doesn’t want to look at you. He’s trying to close his eyes.”

We are a culture that marinates in our frustrations, anger and judgments.

“Can you believe the food cart only had chicken or fish and didn’t have a vegan/vegetarian/dairy-free option?” someone might ask.

“Would you have bought something from the cart?” we might reply.

“Heavens, no. Did you see the prices? I’m just saying they ought to offer it.”

Each flight starts with informative details. “We’ll be flying at 34,000 feet,” the captain might share in his best “The Right Stuff” voice.

“Excuse me, miss? Can we fly at 33,000 feet? My doctor suggested I stay below 33,000 feet because anything higher triggers the side effects from the drug I’m taking because of that ad on TV.”

Then there’s all the beeps. Bing! “You can move about the cabin now but keep your seat belt fastened when you’re in your seat.” Bing! “The restroom in the front is just for the first-class passengers, regardless of how badly you have to go to the bathroom because you ate nine hours of food so you wouldn’t be hungry and have to buy a meal on the plane.”

How about putting the people who want to invent new, safe and potentially delicious food options together with the airlines, giving people a chance to sample new foods? We’re a captive audience, watching movies, playing cards, reading and wondering whether we should be eating breakfast or dinner, depending on whether we’re trying to keep our stomachs on the local time in the place we left or the local time in the place we’re going to. While we’re sitting there, let’s watch independent films we can’t see in the suburbs and eat food that comes from the land we’re flying over.

I love those images of our plane that indicate where we are located. Too bad for Rhode Island and Delaware that the image is often bigger than the entire state. That could exacerbate a small state’s inferiority complex. The Wright brothers may have gotten us started, but we seem to have flown off course on our commercial flight conveniences. Bing!

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Jessica Tollkuhn. Photo from the lab of Michael G. Rosenfeld

Mickey Mouse, if he were a real mouse, would engage in typical male behavior: He’d be aggressive toward other males, he’d look for a mate, presumably Minnie, and he’d mark his territory.

Jessica Tollkuhn, an assistant professor at Cold Spring Harbor Laboratory, would like to uncover how and when signals from hormones trigger a series of genetic steps that lead to characteristic sex-specific behaviors. A molecular biologist by training, Tollkuhn joined CSHL last September.

Ultimately, understanding these steps may help with treatments for human conditions that have different outcomes, depending on the sex of the individual. “There are a lot of sex differences in mental health disorders,” Tollkuhn said. “Autism, ADHD and dyslexia are all more common in men and boys while mood disorders are more common in girls and women.”

While the steps from exploring sex differences in mice to extrapolations to humans are large, the types of experiments Tollkuhn conducts can provide a potential window into the molecular pathways that lead to these mental health challenges.

Tollkuhn’s studies exploring differences in the development of the male and female brain may “give us insights into how these circuits are different,” said Stephen Shea, an associate professor at Cold Spring Harbor Laboratory. Her work could “bring us closer to treatment” and to “understanding” the causes of the disparity in these mental health diseases between the sexes.

Shea is interested in species typical natural behaviors, including sexual behaviors in mice, he said. He studies those from a behavioral and circuit perspective, while Tollkuhn works on tools to understand how those are regulated at the genetic level. He said that has created “a natural collaboration for us.”

Tollkuhn works with neuroscientists at CSHL to connect behavior and development with the genetic steps that lead to those behaviors. She provides “a bridge between areas,” Shea said. “She has a multidisciplinary aspect that fits well with Cold Spring Harbor Laboratory, which unites people and draws links between separate areas.”

For Tollkuhn, mice present a model system that allows her to explore key moments in development. Researchers have shown that exposure to testosterone at birth, which is gone within 24 hours, leads to male mouse behaviors later in life.

Mice are born with almost all their neurons. The wiring occurs during their first two weeks of life, she said.

In the brain, an enzyme called aromatase turns that hormone into estrogen. The bump in the hormones in the brain “are necessary and sufficient to masculinize brain development,” in mice and other rodents, Tollkuhn said. “You can see changes in gene expression, in brain wiring patterns, and in behaviors” all from that narrow window of time.

Indeed, female mice that have estrogen in their brains during this critical early period become masculinized and will fight with other males when they get older. “Transient events in development have long-lasting effects on the brain and behavior,” Tollkuhn said. The cells in the brain that respond to the presence of hormone during development are located in the hypothalamus and the amygdala.

Tollkuhn said her long-standing interest is in understanding how genes define cell identity and function. In the brain, exploring how cells lead to behavior is a challenging question because scientists are just beginning to understand what each cell type does and how they are connected.

The sex differences are a model system Tollkuhn uses to understand the relationship between genes and behavior. She is studying how genes are turned on and off during development. The sex-specific behaviors of mice present opportunities to explore innate behaviors that don’t have to be trained.

In her work, Tollkuhn is profiling gene expression — looking at what genes are on or off — and chromatin — a combination of DNA and protein — in the brain. She’s doing this specifically in the neurons that have the receptor for estrogen.

Tollkuhn “has tools to assess chromatin,” Shea said. Tollkuhn has been “canny in developing or incorporating new techniques for sequencing DNA and understanding chromatin structure and she’s positioned herself at the forefront of those technologies.” Her greatest strength, he continued, is that she’s “put the pieces of these two worlds — the neuroscience of sex in the brain with these cutting edge techniques” together.

A resident of Huntington, Tollkuhn and her husband Joe Mulvaney, who writes software for scientists, have two sons. Franklin is four and a half and Linus is one.

Tollkuhn said she appreciates the family friendly environment at CSHL. “It’s nice to be somewhere where it’s not just okay, but it’s a positive to have family around at the lab and campus,” she said. She described her colleagues in the community at Cold Spring Harbor Laboratory as “fantastic.”

As for her work, Tollkuhn said she hopes to find new molecular targets for therapies and medications to treat mental health diseases.