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brain function

A lack of exercise may rewire our brains. METRO image

By David Dunaief, M.D.

Dr. David Dunaief

Are 20-somethings more quick-witted than people over 60? You might be surprised by what the research actually tells us. Fear of — and assumptions about —cognitive decline as we age are common. They’re so common that entire industries focus on selling us supplements and games to keep us sharp. Ageism is also a growing concern in society and in the workplace.

What do we really know about the brain? We know that certain drugs, head injuries and lifestyle choices can have negative effects. Numerous neurological, infectious, and rheumatologic disorders and diseases can also have long-term brain effects. These include autoimmune disorders, psychiatric mood disorders, diabetes and heart disease.

Of course, addressing the underlying medical issue is critical. Fortunately, several studies also suggest that we may be able to help our brains function more effectively with rather simple lifestyle changes: sleep, exercise and possibly omega-3s.

What is brain clutter?

Let’s return to our question comparing those in their 20s with those over 60.

German researchers put this stereotype to the test. They found that educated older people tend to have a larger mental database of words and phrases to draw upon when responding to a question (1). When this was factored into their simulation analysis, the difference in terms of age-related cognitive decline became negligible.

The more you know, the harder it becomes to come up with a simple answer to something.

What if we could reboot our brains, just like we do with a computer? This may be possible through sleep, exercise and omega-3s.

How does sleep help with brain functioning?

Researchers have identified a couple of specific values we receive from sleep: one involves clearing the mind, and another involves productivity.

For the former, a study done in mice shows that sleep may help the brain remove waste, such as beta-amyloid plaques (2). When we have excessive plaque buildup in the brain, it may be a sign of Alzheimer’s. When mice were sleeping, the interstitial space (the space between brain structures) increased by as much as 60 percent.

This allowed the lymphatic system, with its cerebrospinal fluid, to clear out plaques, toxins and other waste that had developed during waking hours. With the enlargement of the interstitial space during sleep, waste removal was quicker and more thorough, because cerebrospinal fluid could reach much farther. A similar effect was seen when the mice were anesthetized.

In an Australian study, results showed that sleep deprivation may have contributed to an almost one percent decline in gross domestic product (3). Why? When people don’t get enough sleep, they are not as productive. They tend to be more irritable, and their concentration may be affected. While we may be able to turn on and off sleepiness on short-term basis, we can’t do this continually.

In one small study, sleep deprivation was compared to alcohol impairment (4). It found that subjects’ response time and accuracy with assigned tasks after 17-19 hours without sleep were comparable or worse than their performance when they had a blood-alcohol concentration (BAC) of .05 percent. With more than 19 hours of sleeplessness, performance equaled .1 percent BAC.

Earlier studies showing similar results led my wife to insist on picking me up, rather than letting me drive home, after 24-hour call hospital assignments during my residency. 

Does lack of exercise rewire your brain?

One study with rats suggests that a lack of exercise can cause unwanted new brain connections. Rats that were not allowed to exercise were found to have rewired neurons around their medulla, the part of the brain involved in breathing and other involuntary activities. This included more sympathetic (excitatory) stimulus that could lead to increased risk of heart disease (5). 

Among the rats allowed to exercise regularly, there was no unusual wiring, and sympathetic stimuli remained constant. This may imply that being sedentary has negative effects on both the brain and the heart. We need human studies to confirm this impact.

Do omega-3 fatty acids improve brain volume?

The hippocampus is involved in memory and cognitive function. In the Women’s Health Initiative Memory Study of Magnetic Resonance Imaging Study, results showed that postmenopausal women who were in the highest quartile of measured omega-3 fatty acids had significantly greater brain volume and hippocampal volume than those in the lowest quartile (6). 

Specifically, the researchers looked at the levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in red blood cell membranes. The source of the omega-3 fatty acids could have been from either fish or supplementation.

It’s never too late to improve brain function. Although we have a lot to learn, we know that there are relatively simple ways we can positively influence it.

References:

(1) Top Cogn Sci. 2014 Jan.;6:5-42. (2) Science. 2013 Oct. 18;342:373-377. (3) Sleep. 2006 Mar.;29:299-305. (4) Occup Environ Med. 2000 Oct;57(10):649-55. (5) J Comp Neurol. 2014 Feb. 15;522:499-513. (6) Neurology. 2014;82:435-442.

Dr. David Dunaief is a speaker, author and local lifestyle medicine physician focusing on the integration of medicine, nutrition, fitness and stress management. For further information, visit www.medicalcompassmd.com or consult your personal physician.

Aerobic exercise is good for the brain. METRO photo
Exercise may improve mild cognitive impairment

By David Dunaief, M.D.

Dr. David Dunaief

As we consider aging, many of us fear loss of our mental capability as much as loss of our physical capabilities. Yet, just as with physical capabilities, age is not the only determinant.

Mild cognitive impairment (MCI) is feared, not only for its own challenges but also because it may lead to dementia, with Alzheimer’s disease and vascular dementia being the more common forms. Prevalence of MCI may be as high as one-in-five in those over age 70 (1). It is thought that those with MCI may have a 10 percent chance of developing Alzheimer’s disease (2).

So, the most compelling questions are: What increases risk and what can we do to minimize the risk of developing cognitive impairment? Many chronic diseases and disorders contribute to MCI risk. These include diabetes, heart disease, Parkinson’s disease and strokes. If we can control these, we may reduce our risk of cognitive decline.

Heart disease creates substantial risk

In an observational study, results demonstrated that those suffering from years of heart disease are at a substantial risk of developing MCI (3). The study involved 1,450 participants who were between the ages of 70 and 89 and were not afflicted by cognitive decline at the beginning of the study. Patients with a history of cardiac disease had an almost two times greater risk of developing nonamnestic MCI, compared to those individuals without cardiac disease. Women with cardiac disease were affected even more, with a three times increased risk of cognitive impairment.

Nonamnestic MCI can affect executive functioning — decision-making abilities, spatial relations, problem-solving capabilities, judgments and language. It is a more subtle form of impairment that may be more frustrating because of its subtlety. It may lead to vascular dementia and may be a result of clots.

Strokes: where is more important than how many

Not surprisingly, stroke may have a role in cognitive impairment. Stroke is also referred to as a type of vascular brain injury. But what is surprising is that in a study, results showed that the location of the stroke was more relevant than the frequency or the multitude of strokes (4). If strokes occurred in the cortical and subcortical gray matter regions of the brain, executive functioning and memory were affected, respectively. Thus, the locations of strokes may be better predictors of subsequent cognitive decline than the number of strokes. Clinically silent strokes that were found incidentally by MRI scans had no direct effect on cognition, according to the authors.

Exercise benefits cognitive functioning

Exercise may play a significant role in preventing cognitive decline and possibly even improving MCI in patients who have the disorder. Interestingly, different types of exercise have different effects on the brain. Aerobic exercise may stimulate one type of neuronal development, while resistance training or weightlifting another.

In an animal study involving rats, researchers compared aerobic exercise to weightlifting (5). Weightlifting was simulated by attaching weights to the tails of rats while they climbed ladders. Both groups showed improvements in memory tests, however, there was an interesting divergence.

With aerobic exercise, the level of the protein BDNF (brain-derived neurotrophic factor) increased significantly. This is important, because BDNF is involved in neurons and the connections among them, called synapses, related mostly to the hippocampus, or memory center. The rats that “lifted weights” had an increase in another protein, IGF (insulin growth factor), that promotes the development of neurons in a different area of the brain. The authors stressed the most important thing is to exercise, regardless of the type.

In another study that complements the previous study, women were found to have improved spatial memory when they exercised — either aerobic or weightlifting (6). Interestingly, verbal memory was improved more by aerobic exercise than by weightlifting. Spatial memory is the ability to recall where items were arranged, and verbal memory is the ability to recall words. The authors suggest that aerobic exercise and weightlifting affect different parts of the brain.

This was a randomized controlled trial that was six months in duration and involved women, ages 70 to 80, who had MCI at the trial’s start. There were three groups in the study: aerobic, weightlifting and stretching and toning. Those who did stretches or toning alone experienced deterioration in memory skills over the same period.

A Centers for Disease Control and Prevention report claims the majority of the adult population is woefully deficient in exercise: Only about 1 in 5 Americans exercise regularly, both using weights and doing aerobic exercise (7).

Diet makes a difference

Several studies show that the Mediterranean diet helps prevent MCI and possibly prevents conversion from MCI to Alzheimer’s (8, 9). In addition, a study showed that high levels of carbohydrates and sugars, when compared to lower levels, increased the risk of cognitive decline by more than three times (5). The authors surmise that carbohydrates have a negative impact on insulin and glucose utilization in the brain.

Cognitive decline should be taken very seriously, and everything that can be done to prevent it should be utilized. Exercise has potentially positive effects on neuron growth and development, and controlling carbohydrate and sugar intake may reduce risk. Of course, if you have cardiovascular disease, making lifestyle changes to reverse or minimize its impact will reap both physical and cognitive rewards. Let’s not squander the opportunity to reduce the risk of MCI, a potentially life-altering disorder.

References:

(1) Ann Intern Med. 2008;148:427-434. (2) uptodate.com. (3) JAMA Neurol. 2013;70:374-382. (4) JAMA Neurol. 2013;70:488-495. (5) J Alzheimers Dis. 2012;32:329-339. (6) J Aging Res. 2013;2013:861893. (7) Morb Mortal Wkly Rep. 2013;62:326-330. (8) Neurology 2013;80:1684-1692. (9) Arch Neurol. 2009 Feb.;66:216-225.

Dr. David Dunaief is a speaker, author and local lifestyle medicine physician focusing on the integration of medicine, nutrition, fitness and stress management. For further information, visit www.medicalcompassmd.com.