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During a meeting of the Port Jefferson Board of Trustees on Monday, Aug. 1, trustee Lauren Sheprow suggested building closer ties between the village government and Stony Brook University experts.

Sheprow, who worked as the university communications officer at SBU for over a decade, proposed the creation of a local think tank composed of resident experts whose specialized knowledge could be used in service to the community. We believe that this is a neat idea, worthy of the public’s attention and further exploration.

Long Islanders sometimes forget that there are world-renowned scholars living among us. SBU is the largest single-site employer on Long Island. This institution harbors thousands of faculty members who are trained specialists in their chosen fields.

Citizens can often feel alienated from their local government. Municipal operations — reports, budgets, meetings, hearings and so on — can appear to be endless drudgery at times. Perhaps, innovative thinkers could be the source of new ideas.

With regularity, we read about various scientific and medical breakthroughs made by SBU faculty members. From the sciences to mathematics, the humanities to the arts, SBU students and faculty are changing our world for the better. These are people of immense talent and wisdom, sometimes an untapped resource in solving local problems.

The community would tap into local experts who could offer up their insights on matters that most affect us. Specialists could advise our elected officials to make better decisions. 

This is not without precedent. During the administration of SBU President John Marburger, there was a community advisory council, or CAC, in which such a relationship was forged. It was disbanded some 15 years ago. Perhaps it’s time to bring that back.

Anything that brings the government closer to the people, injecting new blood and ideas into the political process, is beneficial to democracy. We should support our local municipalities in strengthening their ties to local universities. This is good for the government, the university and the people.

File photo by Heidi Sutton/TBR News Media

The Port Jefferson Board of Trustees delivered several important announcements to the public during its monthly general meeting on Monday, Aug. 1.

During the business meeting, the board accepted the resignation of village administrator Joe Palumbo, effective Aug. 12. This marks the end of Palumbo’s nearly three years of service in that role.

Along with the resignation of the village administrator, Mayor Margot Garant announced multiple appointments, naming Deputy Mayor Kathianne Snaden as trustee liaison to the Planning Board and the Zoning Board of Appeals. Trustee Rebecca Kassay will take over as the village’s commissioner of environmental sustainability. In addition, residents Gerard Gang and Jennifer Testa were appointed to the Architectural Review Committee.

Mayor’s report

During the general meeting, Garant delivered several updates on projects at East Beach that will affect residents in the coming weeks. Construction of the lower wall at East Beach to stabilize the bluff will begin next week. The mayor predicts the project will take approximately eight months to complete.

“You’ll start to see large boulders and the steel being delivered to the parking lot area,” Garant said. “They’re going to start to mobilize with construction. Unfortunately, the beach, folks, will be closed. You can walk down, but you’ve got to stay away from the major construction.”

About 450 lineal feet of bluff line will be sloped and revegetated, likely sometime in the spring. “It’s a long project, it’s a lot of stabilization, and that is underway,” Garant said.

The mayor also announced that plans to construct an upper wall to protect the clubhouse at the Port Jefferson Country Club will be going out to bid. This next step, according to the mayor, will allow the board to gather more information as it prepares to make a final determination on how to proceed with regards to that facility.

“That project will be going out to bid just so we can get the information and see what the numbers look like,” she said. “We need to have the hard numbers before we can make any real decisions. We will be making a presentation to the public, informing you all along the way.” She added, “It’s a pretty complicated process.”

Concluding her report, Garant announced that the village will partner with the Long Island Seaport and Eco Center to commission a whaleboat.

“It’s not a whaleboat to go fishing for whales,” she said, jokingly. “It’s a whaleboat that was famously used during the [Culper] Spy Ring … Our whaleboat will be something we can use for programming and for demonstrations down at the museum.”

Trustee reports

Snaden provided an update on the roadway obstruction at the intersection of Arlington Avenue and Route 25A. She was pleased to see that the New York State Department of Transportation had resumed construction at that site.

“You can see that a lot of work has been done,” the deputy mayor said. “Most recently, they have started the layers of paving and they are still on track to be finished with that and [have] that road open hopefully by the end of summer.”

Trustee Lauren Sheprow delivered several updates on the status of the Recreation Department. She first highlighted the close relationship the village recreation director has forged with the Port Jefferson School District.

The newest member of the board also announced a village-wide golf outing scheduled for Sept. 22. The fee for the event is $50, which will cover 18 holes of golf at the PJCC along with cart fees, green fees, food and prizes.

“We are opening up our golf outing to the entire Port Jefferson community,” Sheprow said. “That will include Port Jefferson Fire Department volunteers, Port Jefferson School District employees, Port Jefferson village employees and all the residents of Port Jefferson village.” She added, “Proof of employment is required, as is proof of residence.”

Sheprow also announced the reinstatement of the village recreation committee, which will be made up of “seven to nine village residents who can provide feedback and guidance, leading to recommendations to the board of trustees for improvements to parks, facilities and recreational programming,” the trustee said. She added that the next step is to establish a charter for the committee and explore possible candidates.

Sheprow also announced her plans to foster a closer relationship between the Village of Port Jefferson and Stony Brook University. Following conversations with the Office of Community Relations at SBU, the village government hopes to tap into resident experts and specialists in service of the village’s aims.

“The village is proposing to establish a think tank of sorts made up of researchers and scientists at Stony Brook [University] who live in Port Jefferson and who can engage and consult on the opportunities and challenges in their hometown village,” Sheprow said. “This can include marine sciences, engineering sciences, environmental sustainability, education, health and wellness, culture, society … it doesn’t stop. There are so many opportunities to bring in the knowledge of these experts.”

Kassay offered her support for this proposal, saying, “I’m looking forward to seeing all of the community members that are engaged in a lot of those initiatives, as well as the university.”

Kassay delivered a brief report, highlighting some of the environmental activities she has undertaken. She said the Conservation Advisory Council is researching municipal bamboo codes.

“This has been brought up by a few residents over the years and increasingly so more recently,” she said.

Trustee Stan Loucks used his report to recognize the Parks Department for its recent efforts to facilitate several events held throughout the village.

“The Parks Department is responsible for a lot of things in the village that a lot of us are not aware of,” he said. “They take care of every park in the village. They take care of a lot of grassy areas in the village that are not considered parks … and I think they deserve a lot of credit.” He added, “Many times you’ll see them out there with the white trucks and the blue uniforms. If you see them working, stop and say ‘Hello’ and thank them for what they do.”

To access the full meeting, visit the village’s YouTube page.

The 27th annual Stony Brook Film Festival, presented by Island Federal Credit Union, wrapped up with a Closing Night Awards Ceremony on July 30.  The evening recognized the outstanding new independent films screened at the festival, which was held at Staller Center for the Arts at Stony Brook University from July 21 to 30. 

This year’s winners included BerenshteinJury Award for  Best Feature; ContraAudience Award for Best Feature; All That Glitters and Summer of Bees tied for the Jury Award for Best Short; Ousmane — Audience Award for Best Short; Peaceful   Opening Night Feature Award; Lost TransportClosing Night Feature Award; Lentini Opening Night Short Award; and Mila Closing Night Short Award.

In addition, Glob Lessons, directed by Nicole Rodenburg and written by Rodenburg and Colin Froeber, received The Spirit of Independent Filmmaking Award which is given every year to a filmmaker whose work exemplifies the spirit and breadth of filmmaking where the focus is on the art and most often produced with an extremely limited budget. 

This year’s Festival bestowed a special Humanitarian Award on Dr. Gabriel Sara, co-star of and consultant on the opening night feature, Peaceful. A cancer specialist at Manhattan’s Mount Sinai West, Dr. Sara helped launch The Helen Sawaya Fund, a philanthropy program whose mission is to enhance the experience of cancer patients through art and music. 

“The dignity and empathy which Dr. Sara brings to his work became the impetus for Peaceful, a film that touched us all so deeply,” said Alan Inkles, Director of the Stony Brook Film Festival. “We are proud to confer [this award] on Dr. Sara for his vital and important work in improving the lives of cancer patients.”

Highlighting the live Awards Ceremony was a presentation by the filmmakers of Red River Road, winner of the 2021 Spirit of Independent Filmmaking Award. Writer/director Paul Schuyler proudly announced that Red River Road was acquired for distribution by Gravitas Films with the help and support of the Stony Brook Film Festival.

“For over 27 years, filmmakers have continually conveyed to us that we are the most hospitable festival they’ve been to,” said Inkles. “We are able to treat our filmmakers like royalty because we have two constituents in mind when we plan our festivals — our filmmakers and our audience. With the support of Island Federal and many of our other supporters, we are proud to provide a full experience to our audience, bringing together filmmakers and cast members from all over the world to give first- hand accounts of their process.”

During the Festival, the Staller Center announced its Fall 2022 Live Performing Arts season which kicks off on Sept. 23 and includes performances by Michael Feinstein, Katherine McPhee and David Foster, and Vic DiBitetto, among others. Visit www.stallercenter.com for the entire Fall season line-up.

Romaine discussed ways in which local government and New York State must adapt to meet the needs of a changing environment. File photo

Town of Brookhaven Supervisor Ed Romaine (R) has served in elected office for decades. In Part I of this two-part series, Romaine discusses the problem of coastal erosion, innovative ideas for recycling and why you won’t see his name on a sign at a town park.

What sparked your interest in environmental protection and which issues concern you the most?

Long ago, I made a choice between my eyes and my ears, and I chose my eyes. People can argue whatever they want, but I’ve seen what this Island was. I grew up on Long Island. I’ve watched it change and I know what it needs.

The things that concern me about this Island are the threat of climate change and rising sea levels, which is why we’ve bought hundreds of acres at Mastic Beach — to convert them back to wetlands, to act as a sponge.

The week before I was elected in 2012, Hurricane Sandy hit. I went down to Mastic Beach, which was part of my original district in the ’80s. I knew the mayor and I went down with Dan Panico [R-Manorville], who was the councilman, and we took a tour.

Neighborhood Road is the road that runs east and west through Mastic Beach. Everything south of Neighborhood Road was flooded. And the other thing I remember about that disaster was the smell. With all the trees and the downed wires sparking, it smelled of sewage because all their cesspools were inundated, and it smelled of oil because they all had above-ground tanks that spilled over.

It was so devastating when I went down there. Mastic Beach has recovered since, but I will never forget the disaster that hurricane caused and the flooding that it unleashed. Marshlands act as sponges that are capable of handling a flood like that. That is why I am deeply invested in trying to buy up as much of the marshland that was built upon years ago and get rid of some of the small homes there.

The other concern is the carbon footprint we leave. I’m a big supporter of renewable energy. When I was a [county] legislator for the 1st District, I bought more land and preserved more farmland than the other 17 districts combined.

The pattern of development has been so intense that we’ve screwed up this Island by sprawl. We should have thought more carefully about the pattern of development here and what we could do in terms of public transport, in terms of public services — and we didn’t.

What is your preferred approach to the issue of eroding bluffs, a growing problem along the North Shore?

Sometimes people live along those bluffs, so you want to see what type of engineering solutions there are to secure or stabilize bluffs. I know the Village of Port Jefferson is debating what to do about the Port Jefferson Country Club because their tennis courts are going to fall in [the Long Island Sound] and then right after that, probably the clubhouse.

My view would be the same as it would be for Mastic Beach — to retreat from the bluffs. But again, sometimes you can’t do that because people live atop them, so you have to look at engineering solutions that would help stabilize the bluffs. It’s Mother Nature at work. Can man-made solutions resolve it? Sure they can … temporarily. Clearly, what should have been done is something that would have prevented building near or on the bluffs.

Can you discuss the recycling initiative that your office has undertaken?

Back in 2017, China announced its [Operation] National Sword policy. It said, “Hey, we’re not buying any more recycled goods from the United States.” Well, that created all types of problems.

Unfortunately with recycling, a lot of what needs to be recycled rests with the State of New York, and they have not been innovative. The [Department of Environmental Conservation] has chosen to be a regulator and not an innovator. Let me give you an example: glass.

Glass is one of the largest contaminants in the recycling process. To recycle, what do you need? You need a marketplace. Recycling doesn’t work if you don’t have a marketplace to reuse the goods that you’re recycling, which is why recycling has collapsed in large parts of this country.

What we’re looking for from the State of New York is called a BUD — a beneficial-use determination. We believe glass should be an aggregate used in concrete. Concrete is the most carbon-intensive production of any substance that we know. And the way you can end that is by substituting glass in that process as an aggregate, and we’ve allocated for that.

What this requires is the state DEC to give us a beneficial-use determination. Now we’ve proved that because we’ve built these huge drainage rings for our recycling center and we got state permission to use glass as the aggregate in the concrete. They are not even looking at that.

At Stony Brook University, there’s a boathouse. It’s painted blue and was built in 1989. Do you know what it was built out of? Ash. The strength of that building is stronger today than the day it was built in 1989. Guess what we do with our ash? We put it in our landfill. Yet we don’t get a beneficial-use determination to use ash in concrete, in asphalt or in other products. This would create a market for glass and ash.

Also, I’m waiting on the state legislation. I have an ally in the state Legislature — an old friend of mine, someone I served with in the [county] Legislature in the ’80s, and we still work together to this day: [Assemblyman] Steve Englebright [D-Setauket]. I’m trying to say, “Steve, what are we doing here? There’s so much we can be doing.” We need a “Bigger, Better Bottle Bill.” We need to create markets for products because if we don’t, recycling will not work and will not be effective.

If you give enough time and you watch a leaky faucet, that water one drop at a time over a long period of time will make a difference. I always remind myself of the one drop of water. Because if you keep on hammering away at it, change will come. If only incrementally, it will come for the better, for things that should come, for things that are so common sense that even the opposition can’t argue against it. And usually, the opposition tends to be monied interests that have some kind of economic benefit to them, not to the society as a whole.

How did you end up in the supervisor’s office?

I started out as a teacher. I taught for 12 years, almost all of it at Hauppauge. I was very active in the teachers union there. I was the treasurer of the teachers union on their executive committee. In fact, one of my students was Jay Schneiderman, the supervisor of Southampton [D] — I taught him seventh-grade social studies.

I was always active, kind of on the sidelines as a volunteer. In 1979, in the Town of Brookhaven — which had been under Democratic control for four years — the Republicans won everything and they needed people to go into town government. I had done a lot of work for the school district on federal and state aid, so they asked me to become a part-time federal and state aid coordinator.

I started there, and the first thing I got was a massive grant for community development. We got a huge, multimillion-dollar grant, but there were conditions on hiring staff. So they asked me to become the first commissioner on housing and community development for the town. I asked the school district to give me a leave of absence — they were very kind and gave me three in a row. And finally I told them, “Look, I’m not going to come back,” because I was into that job. I did that for five years and loved it.

All the sudden, the [county] legislative seat in which I lived had opened up and they asked me to run. Even though it was a little bit less money, I thought about it for a while and I said “yes.” I ran and was elected to the Legislature in ‘85 and then again in ‘87. I was getting ready to run again when our county clerk died. In between, I had run for Congress and did very well — I got 49.6% of the vote against an incumbent, Mr. [George] Hochbrueckner [D-NY1].

I ran for county clerk, won all 10 towns and went on to win five elections as county clerk. In that time, I had moved, the lines had changed and I got elected to the 1st Legislative District as their county legislator, which included all of eastern Brookhaven from Shoreham to where I live in Center Moriches, as well as Riverhead, Southold and Shelter Island. I loved that district and didn’t lose an election district for the four times I ran. And I was getting ready to run again when Mr. [Mark] Lesko [D], who was the [Brookhaven] supervisor, resigned midterm.

I was asked to run for supervisor and I thought long and hard about that. The major reason I did that was because I had a son [Keith] who was a town councilman and died in office. He always told me that at some point in life he wanted to be a supervisor. That motivated me to say “yes.” I wound up winning five terms as supervisor. So that’s the very short synopsis of a long story.

Brookhaven is an old township that has endured for three-and-a-half centuries. What does it mean to you to be a part of that tradition, and what do you see as your place in it?

The one thing I know about history is that people are quickly forgotten. That’s why I made sure that when I became supervisor, I said, “Other than in Town Hall, I don’t want my name on any town signs or anything.” And you will not see my name on a town park or anything because I made it clear that I’m just passing through.

I believe one of the greatest things I did was save 1,100 acres and put them in the Central Pine Barrens — 800 of which was National Grid property. The legacy that I leave will be a legacy that benefits people, but they will not know it was me.

The temperatures at the poles are heating up more rapidly than those at the equator. Pixabay photo

By Daniel Dunaief

On any given day, heat waves can bring record-breaking temperatures, while winter storms can include below average cold temperatures or snow.

Edmund Chang. Photo from SBU

Weather and climate experts don’t generally make too much of a single day or even a few days amid an otherwise normal trend. But, then, enough of these exceptional days over the course of years can skew models of the climate, which refers to average temperature and atmospheric conditions for a region.

If the climate is steady, “we should see approximately the same number of hot and cold records being broken,” said Edmund Chang, Professor at the School of Marine and Atmospheric Sciences at Stony Brook University. “Over the past few decades, we have seen many more hot records being broken than cold records, indicating the climate is getting hotter.”

Recent heat

Indeed, just last week, before a heatwave hit the northeastern United States, the United Kingdom reported the hottest day on record, with the temperature at Heathrow Airport reaching above 104 degrees.

Erinna Bowman, who grew up in Stony Brook and has lived in London since 2009, said the temperature felt “like a desert,” with hot, dry heat radiating up in the urban setting. Most homes in London don’t have air conditioning, although public spaces like supermarkets and retail stores do.

“I’m accustomed to the summer getting quite hot, so I was able to cope,” said Bowman. Indeed, London is usually considerably cooler during the summer, with average temperatures around 73 degrees.

Michael Jensen. Photo from BNL

News coverage of the two extraordinarily hot days in London “was very much framed in the context of a changing climate,” Bowman said. The discussion of a hotter temperature doesn’t typically use the words “climate change,” but, instead, describes the phenomenon as “global heating.”

For climate researchers in the area, the weather this summer has also presented unusual challenges.

Brookhaven National Laboratory meteorologist Michael Jensen spent four years planning for an extensive study of convective clouds in Houston, in a study called Tracking Aerosol Convection Interactions, or Tracer.

“Our expectation is that we would be overwhelmed” with data from storms produced in the city, he said. “That’s not what we’re experiencing.”

The weather, which has been “extremely hot and extremely dry,” has been more typical of late August or early September. “This makes us wonder what August is going to look like,” he said.

Jensen, however, is optimistic that his extensive preparation and numerous pieces of equipment to gather meteorological data will enable him to collect considerable information.

Warming at the poles

Broadly speaking, heat waves have extended for longer periods of time in part because the temperatures at the poles are heating up more rapidly than those at the equator. The temperature difference between the tropics and the poles causes a background flow from west to east that pushes storms along, Chang explained.

The North Pole, however, has been warming faster than the tropics. A paper by his research group showed that the lower temperature gradient led to a weakening of the storm track.

When summer Atlantic storms pass by, they provide relief from the heat and can induce more clouds that can lead to cooler temperatures. Weakening these storms can lead to fewer clouds and less cooler air to relieve the heat, Chang added.

Rising sea levels

Malcolm Bowman. Photo from SBU

Malcolm Bowman, who is Erinna Bowman’s father and is Distinguished Service Professor at the School of Marine and Atmospheric Sciences at Stony Brook University, believes the recent ice melting in Greenland, which has been about 10 degrees above normal, could lead to a rise in sea levels of about one inch this summer. “It will slowly return to near normal as the fresh water melt spreads slowly over all the world’s oceans,” he added.

Bowman, who has studied sea level rises and is working on mitigation plans for the New York area in the event of a future major storm, is concerned about the rest of the hurricane season after the level of warming in the oceans this summer. 

“Those hurricanes which follow a path over the ocean, especially following the Gulf Stream, will remain strong and may gather additional strength from the heat of the underlying water,” he explained in an email.

Bowman is the principal investigator on a project titled “Long Island South Shore Sea Gates Study.”

He is studying the potential benefit of six possible sea gates that would be located across inlets along Nassau and Suffolk County. He also suggests that south shore sand dunes would need to be built up to a height of 14 feet above normal high tide.

Meanwhile, the Army Corps of Engineers has come up with a tentatively selected plan for New York Harbor that it will release some time in the fall. Bowman anticipates the study will be controversial as the struggle between green and grey infrastructure — using natural processes to manage the water as opposed to sending it somewhere else — heats up.

As for the current heat waves, Bowman believes they are a consistent and validating extension of climate change.

Model simulations

In his lab, Chang has been looking at model simulations and is trying to understand what physical processes are involved. He is comparing these simulations with observations to determine the effectiveness of these projections.

To be sure, one of the many challenges of understanding the weather and climate is that numerous factors can influence specific conditions.

“Chaos in the atmosphere could give rise to large variations in weather” and to occasional extremes, Chang said. 

Before coming to any conclusions about longer term patterns or changes in climate, Chang said he and other climate modelers examine collections of models of the atmosphere to assess how likely specific conditions may occur due to chaos even without climate change.

“We have to rule out” climate variability to understand and appreciate the mechanisms involved in any short term changes in the weather, he added.

Still, Chang said he and other researchers are certain that high levels of summer heat will be a part of future climate patterns. 

“We are confident that the increase in temperature will result in more episodes of heat waves,” he said.

Paolo Boffetta. Photo by Jeanne Neville/Stony Brook Medicine

By Daniel Dunaief

Screening for cancer can help people take steps to head off the development of a disease that could threaten the quantity and quality of their lives.

During the start of the pandemic, people around the world stopped screening for cervical, breast and colorectal cancer, according to a recent study led by Paolo Boffetta, Associate Director for Population Sciences at Stony Brook University’s  Cancer Center.

The results of the study were recently published in the journal JAMA Oncology.

Compared to 2019, screenings for breast cancer dropped in the first few months after the start of the pandemic by 35.6 percent for breast cancer, 41.8 percent for colorectal cancer, and 54.1 percent for cervical cancer compared to the same period in 2019.

Paolo Boffetta. Photo by Jeanne Neville/Stony Brook Medicine

Boffetta chose these three cancers because they are the ones public health authorities recommend for the population at large. Screenings can improve patient outcomes. 

“For some/ most cancer, the earlier the better for detection,” explained Stony Brook Cancer Center Director Yusuf Hannun.

Boffetta, who is also Adjunct Professor at the Icahn School of Medicine at Mount Sinai in New York City, suggested that the longer-term impact of a reduction in screenings in the early part of the pandemic won’t be clear to doctors or patients in the short term.

“It will take a little bit of time to have a full understanding of this,” said Boffetta. Depending on the specific type, cancers “that are detected by screenings would not otherwise appear for a few years.”

Boffetta suggested that the pandemic, apart from the illnesses and symptoms that threatened the health of people who were battling the virus itself, affected public health services. He believes several factors likely contributed to the decrease in screenings. Patients around the world were reluctant or restricted in their ability to leave their homes amid lockdowns.

Additionally, some cancer centers likely reduce the number of people they monitored to cut back on the density of patients in health care facilities, although Boffetta did not gather any data on the reduction in the number of screenings at health care centers.

The positive news amid this study, which surveyed cancer screening data in PubMed and other medical journals from 19 countries from January 2020 through December 2021, was that the number of patients screened returned to a more normal level within several months of the start of the pandemic.

“An important finding is that by the summer of 2020, the decrease in screenings for breast cancer and cervical cancer seem to have disappeared,” Boffetta said by phone from Italy, where he is a part-time professor at the University of Bologna. “For colorectal cancer [the decrease in screenings] lasted longer,” through the end of 2020.

Boffetta described the reduction in screenings and then a return to normal as a U-shaped curve, with an initial decline followed by a recovery. Doctors typically screen for colorectal cancers by using a colonoscopy. This technique requires several hours in the hospital. Patients may have been “more reluctant to go back to such a complex procedure, compared to the mammography or pap smear” which screen for breast and cervical cancers, respectively.

Boffetta is conducting a broad study of the cancer literature from early findings to clinical diagnosis to treatment. At this point, he has finished a paper on the frequency and types of clinical diagnoses amid the pandemic. He is collecting data for another study that will examine cancer treatment.

“We are interested in how the pandemic affected each of these stages,” he said.

Hannun suggested that Boffetta’s work expertise help address important health care questions related to the pandemic and other threats to public health, adding, “Epidemiology is essential for understanding the pandemic and many chronic diseases, especially cancer with exposure issues.

A lab update

Boffetta joined Stony Brook University in April of 2020, soon after the start of the pandemic.

Also a Professor in the Department of Family, Population and Preventive medicine at the Renaissance School of Medicine at Stony Brook University, Boffetta will return to the United States in a few weeks from Italy.

Boffetta has added Research Coordinator Germana Giupponi and postdoctoral fellow Malak Khalifeh to his research efforts at Stony Brook. 

Germana Giupponi

A native of Italy, Giupponi, who started working with Boffetta in July of 2020 and provides administrative support and coordination with Boffetta’s collaborators, earned her master’s degree from the University of Milan.

Khalifeh joined Boffetta’s lab in March, is originally from Lebanon and conducted her PhD research in France at the University of Bordeaux. She is studying the link between the exposure people have to various chemicals in drinking water and bladder cancer. The bladder is especially susceptible to toxins from the environment.

Boffetta, meanwhile, has started teaching some graduate level classes at Stony Brook on cancer epidemiology for master’s and PhD students. He will teach one class this fall.

He is also continuing his studies with survivors of the World Trade Center attacks.

He has been comparing the survival of these first responders to the overall population in New York, comparing how the risk of cancer changed over the course of the 21 years since the attacks.

Boffetta has been working with Ben Luft, Director of the Stony Brook WTC Wellness Program at the Renaissance School of Medicine. Luft has provided clinical and research support for WTC responders.

Boffetta continues to have academic affiliations with other academic institutions, including Harvard University and Vanderbilt University.

Boffetta and his wife Antonella Greco, who have been living in New York City, plan to move to the Stony Brook area. Their three daughters live in Brooklyn, Italy and Argentina. Now that pandemic restrictions have lifted, Boffetta has been able to return to the opera and museums and has done some skiing and hiking.

As for this study, Boffetta suggested that the findings about screenings were consistent with what he might have expected during the beginning of the pandemic.Delaying screenings could mean that some people discover cancers at a more advanced state by the time they diagnose them, he said.

Dr. Peter Igarashi is the incoming dean of the Renaissance School of Medicine. Photo from University of Minnesota

Stony Brook University’s Renaissance School of Medicine has named Dr. Peter Igarashi, a nephrologist and physician scientist, as its new dean, effective Sept. 12.

Igarashi comes to Stony Brook from the University of Minnesota Medical School, where he is the Nesbitt Chair, professor and head of the Department of Medicine.

At the University of Minnesota, the new dean oversaw 600 full-time and affiliate faculty, 100 adjunct faculty, and over 240 residents and fellows, all while increasing National Institutes of Health funding by 60%.

At UMN, he also helped to cut gender pay disparities, appointed women to leadership positions, developed new multidisciplinary programs, and created an Office of Faculty Affairs and Diversity.

“Dr. Igarashi is a superb, academically accomplished physician leader with a highly successful track record of clinical program growth and research advancement,” Dr. Hal Paz, executive vice president of Health Sciences at SBU and chief executive officer of Stony Brook University Medicine, said in a statement. 

Igarashi has received over $25 million in funding from the NIH during a career in which he has studied polycystic kidney disease, transcriptional regulation, epigenetics and kidney development.

Polycystic kidney disease, or PKD, is an inherited disorder that involves the development of clusters of cysts, primarily in the kidney. Symptoms of the disease can include high blood pressure, loss of kidney function, chronic pain and the growth of cysts in the liver, among others.

His lab developed unique lines of transgenic mice that he has used to study kidney-specific transgene expression and gene targeting.

In addition to writing nine chapters in textbooks, Dr. Igarashi has also authored more than 100 peer-reviewed journal articles.

Before his seven-year stint at the University of Minnesota, Dr. Igarashi had been Chief of the Division of Nephrology and founding director of the O’Brien Kidney Research Core Center at the University of Texas Southwestern Medical Center in Dallas.

At the University of Texas, Dr. Igarashi created services to provide regular kidney dialysis to undocumented and other often marginalized patients. He also led an effort to use artificial intelligence to identify and optimize co-management of patients with hypertension, diabetes, and chronic kidney disease in primary care practices.

A recipient of the NIH Merit Award, Dr. Igarashi also won the 2015 Lillian Jean Kaplan International Prize in polycystic kidney disease. The award honored his contribution to the goal of developing treatments and a cure for polycystic kidney disease.

Dr. Igarashi earned his medical degree from the UCLA School of Medicine and completed an internal medicine residency at the University of California Davis Medical Center. He did a nephrology fellowship at Yale University and also taught at the Yale University School of Medicine.

Dr. Igarashi is board-certified by the American Board of Internal Medicine. He is a member of the American Heart Association Kidney Council, the American Physiological Society, the American Society for Clinical Investigation, the American Society of Nephrology and the Association of American Physicians.

Dr. William Wertheim had been the interim dean of the Renaissance School of Medicine since February 2021, following Dr. Kenneth Kaushansky’s retirement after serving as dean and senior vice president of health sciences for 11 years.

Dr. Wertheim will return to his role as vice dean for graduate medical education. He will also have a leadership role at the Stony Brook Medicine Community Medical Group, which is an arm of Stony Brook Medicine and includes over 35 community practices with over 50 locations across Long Island.

The SK 48 cranium of an ancient hominin, Paranthropus robustus, was one of the fossils included in the analysis of some new claims on human evolution. Photo by Carrie S. Mongle

Uncovering the evolution of any set of living creatures is a complex and highly detailed task for scientists, and theories and approaches that may differ over time may indeed change the fossil record. But paleoanthropologist and Stony Brook University Professor Carrie S. Mongle, PhD, and co-authors urge investigators to take caution on their findings. They provide researchers investigating the evolutionary past of ancient hominins (a group including humans and our immediate fossil ancestors) an important and foundational message in a recent paper published in Nature Ecology & Evolution. That is – conclusions drawn from evolutionary models are only as good as the data upon which they are based.

In “Modelling hominin evolution requires accurate hominin data,” the authors develop a response to a previous research paper that had made some major claims on when the genus Homo emerged based on fossil dates. The team, however, proved that many of the fossil dates from the study were wrong, and they provided data to correct these errors.

“It has become increasingly common in our field for researchers to propose a ‘new and exciting’ synthesis of evolutionary events that a given group of scientists think overturns our understanding of human evolution,” says Mongle, Assistant Professor in the Department of Anthropology and Turkana Basin Institute. “Our paper is meant to draw attention to the issue that we cannot make major claims based on piecemeal compilations of the fossil record and questionable data from literature. We also offer a carefully constrained geochronological dataset for researchers to use for future studies.”

Mongle and co-authors found that by re-analyzing the original study with corrected fossil dates, the estimated timing of species divergences differed by as much as 300,000 years from the previously reported estimates. This is important because these estimates are often used to correlate evolutionary transitions with ancient environments and climate change. When estimates are off by this much, it can completely change scientists’ interpretations of the evolutionary drivers that made us human.

Mongle and co-authors make the case for evolutionary scientists to develop future total evidence studies when studying human evolution. They conclude that it is “critical to recognize that no algorithm is a replacement for careful comparative anatomy and meticulously constrained geochronology when it comes to interpreting evolutionary trends from the fossil record.”

Markus Seeliger, third from left, with members of his lab, from left, Terrence Jiang. Aziz Rangwala, Ian Outhwaite, Victoria Mingione,YiTing Paung, and Hannah Philipose. Photo from Markus Seeliger

By Daniel Dunaief

When a dart hits the center of a target, the contestant often gets excited and adds points to a score. But what if that well-placed dart slipped off the board before someone could count the points, rendering such an accurate throw ineffective?

With some cases of cancer treatments, that’s what may be happening, particularly when a disease develops a mutation that causes a relapse. Indeed, people who have chronic myeloid leukemia typically receive a treatment called Imatinib, or Gleevac.

The drug works, hitting a target called a kinase, which this white blood cell cancer needs to cause its cells to continue to divide uncontrollably. Patients, however, develop a mutation called N368S, which reduces the effectiveness of the drug.

While mutations typically make it more difficult for a drug to bind to its target, that’s not what’s happening with this specific mutation. Like the dart hitting the center of a board, the drug continues to reach its target.

Instead, in a model of drug resistance several scientists have developed, the mutation causes the drug to decouple.

Pratyush Tiwary with this year’s US top 20 students who are going to the international chemistry olympiad. Photo from Toward

A team of experimental and computational researchers including Markus Seeliger, Associate Professor of Pharmacological Sciences at Stony Brook University, and Pratyush Tiwary, Associate Professor in the Department of Chemistry & Biochemistry at the University of Maryland, published two research papers explaining a process that may also affect the way mutations enable resistance to other drugs.

Seeliger described how different disease-associated mutations bind to Gleevac in a paper published in the Proceedings of the National Academy of Sciences. 

Working with scientists at Memorial Sloan Kettering Cancer Center and Goethe University in Frankfurt, Germany, Seeliger used nuclear magnetic resonance spectroscopy, or NMR. The researchers showed how the drug bound to its target and then released.

Understanding the way diseases like cancer develop such resistance could affect drug discovery, giving pharmaceutical companies another way to prepare for changes diseases make that reduce the effectiveness of treatments.

A ‘hot paper’

Tiwary published research in which Seeliger was a coauthor in late April in the journal Angewandte Chemie that the publication labeled a “hot paper” for its implications in the field. Tiwary developed a way to simulate the kinetic processes that enable the mutated kinases to release the drug.

Tiwary created an artificial intelligence model that extended the time he analyzed the drug-protein interaction from milliseconds all the way out to thousands of seconds.

“Even within the simulation world, if you can quantitatively predict a binding affinity, that’s amazing,” Seeliger said. “It’s extremely hard to calculate kinetics, and he got that right.”

Tiwary, who started talking with Seeliger about five years ago and has been actively collaborating for about three years, uses experimental data to inform the dynamics that affect his simulations.

Seeliger “had done the experiments of the dissociation rates beforehand, but did not have a way to explain why they were what they were,” Tiwary explained in an email. “Our simulations gave him insights into why this was the case and … insight into how to think about drugs that might dissociate further.”

Drug discovery

Tiwary hopes the work enables researchers to look at structural and kinetic intermediates in reactions, which could provide clues about drug design and delivery. While he worked with a single mutation, he said he could conduct such an analysis on alterations that affect drug interactions in other diseases.

He wrote that the computations, while expensive, were not prohibitive. He used the equivalent of 16 independent 64 CPUs for one to two weeks. He suggested that computing advances could cut this down by a factor of 10, which would enable the exploration of different mutations.

“The methods are now so easy to automate that we could run many, many simulations in parallel,” Tiwary explained. Machine learning makes the automation possible.

Given what he’s learned, Tiwary hopes to contribute to future drug begin that addresses mutation or resistance to treatment in other cancers. He also plans to continue to work with Seeliger to address other questions.

Next steps

Seeliger said he plans to extend this work beyond the realm of this specific type of cancer.

He will explore “how common these kinetic mutations are in other systems, other diseases and other kinases,” Seeliger said.

He would also like to understand whether other proteins in the cell help with the release of drugs or, alternatively, prevent the release of drugs from their target. The cell could have “other accessory proteins that help kick out the drug from the receptor,” Seeliger said.

The concept of drug resistance time comes from infectious disease, where microbes develop numerous mutations.

Seeliger, who is originally from Hanover, Germany, said he enjoys seeing details in any scene, even outside work, that others might not notice. 

He described how he was driving with postdoctoral fellows in Colorado when he spotted a moose. While the group stopped to take a picture, he noticed that the moose had an ear tag, which is something others didn’t immediately notice.

As for the research collaboration, Seeliger is pleased with the findings and the potential of the ongoing collaboration between experimental and computational biologists.

“The computational paper, aside from using interesting new methodology, describes why things are happening the way they are on a molecular level,” he said.

Study authors Liwei Yang, left, and Jun Wang, in the Wang laboratory by the microscope that incorporates the single-cell cyclic multiplex in situ tagging (CycMIST) technology to analyze proteins on single cells. Photo provided by Jun Wang

A new biomedical research tool that enables scientists to measure hundreds of functional proteins in a single cell could offer new insights into cell machinery. Led by Jun Wang, Associate Professor of Biomedical Engineering at Stony Brook University, this microchip assay — called the single-cell cyclic multiplex in situ tagging (CycMIST) technology – may help to advance fields such as molecular diagnostics and drug discovery. Details about the cyclic microchip assay method are published in  Nature Communications.

While newer technologies of single-cell omics (ie, genomics, transcriptomics, etc.) are revolutionizing the study of complex biological and cellular systems and scientists can analyze genome-wide sequences of individual cells, these technologies do not apply to proteins because they are not amplifiable like DNAs. Thus, protein analysis in single cells has not reached large-scale experimentation. Because proteins represent cell functions and biomarkers for cell types and disease diagnosis, further analysis on a single-cell basis is needed.

“The CycMIST assay enables comprehensive evaluation of cellular functions and physiological status by examining 100 times more protein types than conventional immunofluorescence staining, which is a distinctive feature not achievable by any other similar technology,” explains Liwei Yang, lead author of the study and a postdoctoral scholar within the Wang research team and Multiplex Biotechnology Laboratory.

Wang, who is affiliated with the Renaissance School of Medicine and Stony Brook Cancer Center, and colleagues demonstrated CycMIST by detecting 182 proteins that include surface markers, neuron function proteins, neurodegeneration markers, signaling pathway proteins and transcription factors. They used a model of Alzheimer’s Disease (AD) in mice to validate the technology and method.

By analyzing the 182 proteins with CycMIST, they were able to perform a functional protein analysis that revealed the deep heterogeneity of brain cells, distinguished AD markers, and identified AD pathogenesis mechanisms.

With this detailed way to unravel proteins in the AD model, the team suggests that such functional protein analysis could be promising for new drug targets for AD, for which there is not yet an effective treatment. And they provide a landscape of potential drug targets at the cellular level from the CycMIST protein analysis.

The authors believe that CycMIST could also have enormous potential for commercialization.

They say that before this study model with CycMIST, researchers could only measure and know a tip of protein types in a cell. But this new approach enables scientists to identify and know the actions of each aspect of a cell, and therefore they can potentially identify if a cell is in a disease status or not – the first step in a possible way to diagnose disease by analyzing a single protein cell. And compared with standard approaches like flow cytometry, their approach with CycMIST can analyze 10 times the amount of proteins and on a single-cell level.

The researchers also suggest that the cyclic microchip assay is portable, inexpensive, and could be adapted to any existing fluorescence microscope, which are additional reasons for its marketability if it proves to be effective with subsequent experimentation.

Much of the research for this study was supported by the National Institutes of Health’s National Institute of Aging (grant # R21AG072076), other NIH grants, and a Memorial Sloan Kettering Cancer Center Support Grant.