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Brookhaven National Laboratory

U.S. Department of Energy Secretary Jennifer Granholm joined scientists from DOE national laboratories for a round table conversation on COVID-19 on March 4. Photo from the Department of Energy.

By Daniel Dunaief

Jennifer Granholm, the new secretary of the Department of Energy, is pleased with the role the 17 national laboratories has played in responding to the COVID-19 pandemic over the last year and is hopeful research from these facilities will aid in the response to any future potential pandemics.

There are “70,000 people who are spread out across America solving problems,” Granholm said in a recent press conference that highlighted the effort and achievement of labs that redirected their resources to tackle the public health threat. 

The DOE is “the solutions department” and has “some of the greatest problem solvers.”

“It is super exciting to talk about this particular issue, the issue of the day, the COVID, and what the lab has been doing about it,” she added.

Granholm, who was confirmed by a Senate vote of 64-35 and was sworn in as secretary on February 25th, had previously been the Attorney General in Michigan and was the first female governor of Michigan, serving two terms from 2003 to 2011.

The press conference included three research leaders from national labs across the country, including Kerstin Kleese van Dam, Director of the Computational Science Initiative at Brookhaven National Laboratory in Upton.

Kleese van Dam was the BNL lead for one of the five DOE teams that tackled some of the scientific challenges caused by the virus. She led the effort to inform therapeutics related to COVID-19.

The other four teams involved manufacturing issues, testing, virus fate and transport, which includes airflow monitoring, and epidemiology.

The public discussion was intended to give people a look at some of the “amazing work that you all are doing,” Granholm said.

The Department of Energy formed the National Virtual Biotechnology Laboratory, or NVBL, to benefit from DOE user facilities, such as the light and neutron sources, nanoscience centers, sequencing, and high-performance computer facilities to respond to the threat posed by COVID-19.

Funding for NVBL enabled BNL scientists to pivot from what they were doing to address the challenge created by the pandemic, John Hill, Director of the National Synchrotron Light Source II, explained in an email.

BNL had been constructing a new facility, called the Laboratory for Biomolecular Structures, prior to the pandemic. The public health threat created by the virus, however, accelerated the time table by two months for the completion of the structure. 

The lab has new cryo-electron microscopes that allow scientists to study complex proteins and the architecture of cells and tissues. The cryo-EM facility contributed to work on the “envelope” protein for the SARS-CoV2 virus, which causes COVID-19.

“We at BNL built a new facility which gives further capabilities to look at the virus during the pandemic,” Kleese van Dam said during the press conference. The lab prepared the facility “as quickly as possible so we could help in the effort.”

Kleese van Dam said the three light sources around the country, including the National Synchrotron Light Source II at BNL, have been working throughout the crisis with the pharmaceutical industry, helping them “refine and improve their medications.”

Indeed, Pfizer scientists used the NSLS-II facility to research certain structural properties of their vaccine. At the same time, researchers have worked on a number of promising antivirals, none of which has yet made it into clinical use.

The national laboratories, including BNL, immediately tackled some of the basic and most important questions about the virus soon after the shutdown last spring.

“There was a period last year, in the depths of the first lockdown in New York, when [the National Synchrotron Lightsource-II] was only open to COVID research,” Hill wrote in an email. “That was done both by BNL scientists and others working with our facility remotely. All other research was on hold.”

The facility reopened to other experiments in May for remote experiments, Hill continued.

Kleese van Dan explained that other projects also had delays.

“These [delays] were up front discussed with collaborators and funders and all whole heartedly supported our shift in research,” said Kleese van Dam. “Many of them joined us in this work.”

Hill said the NSLS-II continues to work on COVID-19 and that much of the work the lab has conducted will be useful in future pandemics. “We are also exploring ways to maintain preparedness going forward,” he continued.

BNL is collaborating with other groups, including private companies, to enable a robust and rapid response to future threats.

“BNL is part of a multi-lab consortium  — ATOM (Accelerating Therapeutics for Opportunities in Medicine) — that aims to pursue the therapeutics work in collaboration with other agencies, foundations and industry,” Kleese van Dam wrote in an email.

In response to a question from Granholm about the safety of schools and the study of airflow, Kleese van Dam explained that national labs like BNL regularly study the way aerosols move in various spaces.

“As a national lab, we study pollution and smoke and things like that,” Kleese van Dam said during the press conference.

The lab tested the virus in the same way, exploring how particles move to understand infections.

“When we think about this, we think about how air moves through small and confined spaces,” Kleese van Dam said. “What I breathe out will be all around you. If we were outside, the air I’m breathing out is mixed with clean and healthy air. The load of the virus particles that arrive are much smaller.”

Using that knowledge, BNL and other national laboratories did quite a few studies, including exploring the effect of using masks on the viral load.

People at numerous labs used computer simulations and practical tests to get a clearer picture of how to reduce the virus load in the air.

Granholm pledged to help share information about minimizing the spread of the virus.

“We’re going to continue to focus on getting the word out,” Granholm said. The labs are doing “great work” and the administration hopes to “make the best use of it.”

Photo from BNL

COVID-19 needs no introduction. Scientists fighting it do.

John Hill leads the COVID-19 Science and Technology Working Group at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory. He also represents Brookhaven in a DOE consortium—the National Virtual Biotechnology Laboratory—which includes all 17 national laboratories working to address key challenges in responding to COVID-19.

The COVID-19 working group Hill leads at Brookhaven comprises experts in biology, nanoscience, computation, and other areas of science. They and their collaborators are leveraging world-class capabilities to study the structure of viral components, narrow the search for drugs, track research efforts, model the disease’s spread, and more.

Hill will give a virtual talk about the impacts of Brookhaven’s multifaceted COVID-19 research on Thursday, Feb. 25. The event, held from 6:30 to 7:30 p.m., will also include an interactive Q&A session, when audience members can submit questions for Hill and two of his colleagues:

How to join the event—and ask a question

This event will stream live on Twitter, Facebook, and YouTube. During the Q&A session, audience members can ask questions, using those streaming platforms’ chat functions.

You don’t need an account with Twitter, Facebook, or Google to watch the talk. You do need an account to ask questions via chat. Or you can email questions to [email protected] before the talk.

About the speakers

John Hill is the Deputy Associate Laboratory Director for Energy and Photon Sciences, and Director of the National Synchrotron Light Source II (NSLS-II), a DOE Office of Science User Facility at Brookhaven Lab. He previously served as leader for the X-ray Scattering group in the Lab’s Condensed Matter Physics and Materials Science Department. He is recognized as a world leader in x-ray scattering techniques for studying condensed matter systems.

Hill joined Brookhaven Lab as a postdoc in 1992, after earning a Ph.D. in physics from the Massachusetts Institute of Technology. He earned a bachelor’s degree in physics from Imperial College in London in 1986.

Kerstin Kleese van Dam is Director of the Computational Science Initiative (CSI) at Brookhaven Lab. CSI leverages computational science expertise and investments across multiple programs to tackle big-data challenges at the frontiers of scientific discovery. Kleese van Dam and collaborators at Brookhaven and Stony Brook University have applied simulations, machine learning, and other artificial intelligence tools in the fight against COVID-19.

Sean McSweeney is the Director of the Laboratory for BioMolecular Structure (LBMS) at Brookhaven. LBMS is home to state-of-the-art cryo-electron microscopes and other equipment for researchers to study the building blocks of all living organisms. Most of the data McSweeney and his group collected for COVID-19 research was done at NSLS-II.

Brookhaven National Laboratory is supported by the U.S. Department of Energy’s Office of Science. The Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time. For more information, visit https://energy.gov/science.

Follow @BrookhavenLab on Twitter or find us on Facebook.

Sam Woronick

Thirteen Suffolk County Community College students have been awarded prestigious and highly competitive internships at Brookhaven National Laboratory (BNL) and are collaborating with renowned scientists and engineers on some of the labs most advanced and emerging research and projects. They include Stefan Baggan, Isaiah Brown-Rodriguez, James Bush, Michael Chin, William Daniels, Benjamin Herr, Danielius Krivickas, Matthew McCarthy, Patricia Moore, Kwaku Ntori, Matthew Warner, Samuel Woronick and Robert Zinser.

“Our College typically places three or four students into this highly competitive paid internship program,” explained Academic Chair and Professor of Engineering/Industrial Technology Peter Maritato, who explained that the students are provided the opportunity to intern under the guidance of scientific and engineering staff on projects that are relevant to the Department of Energy’s mission through transformative science and technology solutions. The 10-week program engages the students in cutting-edge scientific research programs, the chance to present research results verbally and/or in writing and collaborations with leaders that may result in a contribution to a scientific journal. Each intern is provided a weekly stipend of $600. Maritato said the internships and training could also lead to possible employment at the lab.

“Securing a BNL internship is a highly competitive process and our success here proves that a Suffolk County Community College education allows our students to compete and succeed against anyone,” said Suffolk County Community College Interim President Louis Petrizzo.

Suffolk County Community College’s Brookhaven National Lab interns are as unique as the national lab itself and the research they are performing. Here’s more about a few of the students who are now collaborating side-by-side with some of the nation’s premier researchers, scientists and engineers.

Patricia Moore, South Setauket, Suffolk graduation: May 2022

Patricia Moore

Twenty-eight-year-old Patricia Moore of South Setauket graduated from Ward Melville High School in 2010, passed on her admission to Rochester Institute of Technology because she was put off by the cost, and came to Suffolk for a semester before leaving because she was not sure what path to pursue. Fast forward four years.

Moore reentered Suffolk part time, worked in retail, started her own business and discovered that her time outside the classroom helped her develop. “The soft skills you develop as a good adult and employee are helpful in the academic environment,” Moore said. Now attending Suffolk full time, Moore is majoring in engineering and collaborating on the development and fabrication of Low-Gain Avalanche Detectors with her mentor at BNL.

 “I’m excited about being educated on Long Island,” Moore said.  “I didn’t know a lot of these resources and great opportunities were available to Long Islanders, and it’s interesting to see how many different people are involved in the many and varied projects and the scope of the work at the lab.” Moore is expected to graduate from Suffolk County Community College in May 2022.

Matt McCarthy, Smithtown, Suffolk graduation: May 2021

Matt McCarthy

McCarthy, 25, graduated from Commack High School in 2013 and entered Suffolk County Community College. McCarthy left Suffolk to join the Marine Corps where he served for five years, earned sergeant’s stripes and was a Fire Team and Squad leader during two overseas tours to Afghanistan and Iraq.

Back home, McCarthy re-entered Suffolk in spring 2019 and is now majoring in IT Network Design and Administration.

At BNL, McCarthy will be interning at the National Synchrotron Light Source II facility in IT networking. “IT is a structured environment I really enjoy,” McCarthy said.  “I’m trying to pick up work experience and reinforce my resume. I hope to eventually land a job with Brookhaven, it would be fantastic to work in an environment like that.” McCarthy said he has been accepted to New York Institute of Technology and looks forward to earning a master’s degree.

“Suffolk prepared me very well,” McCarthy said, “I was shocked at the rigor and difficulty of my classes. I compare myself to my peers studying at different colleges and universities, and I am one or two steps ahead.”

Matthew Warner, Shirley, Suffolk graduation: December 2020

Matt Warner

Warner, 30, married with a young daughter, attended Suffolk straight out of William Floyd High School (2009), but said he left after recognizing he was not focused and unsure of what he wanted to do. Warner returned to Suffolk and majored in Construction and Architectural Technology, and earned a certificate in drafting. Warner’s goal is to continue his education at Farmingdale State College and earn a master’s degree in architecture. Warner is collaborating on technical engineering at BNL. “I’m hoping there will be a career opportunity available at the conclusion of my internship,” Warner said,

James Bush, Shirley, Suffolk graduation: May 2021

Bush, 20, is a 2018 William Floyd High School graduate majoring in Electrical Technology. At BNL Bush interns in the Superconducting Magnet Division where he is studying high power current sources and techniques to disperse energy from magnets if they begin to overheat. “The internship is a great experience,” Bush said. “I never realized how competitive it was until I met everyone and the BNL staff. I’m excited about this opportunity, and perhaps working for BNL in the future.

Sam Woronick, Center Moriches, Suffolk graduation: May 2022

Sam Woronick

Woronick is a 2019 Center Moriches High School graduate now majoring in Cybersecurity and Computer Science at Suffolk County Community College. Woronick is doing IT at BNL that supports Quantum Free-Space Link.  Woronick is analyzing data from two software programs written for the Windows Operating System with a goal of providing researchers with better control by working to get the software to run in Linux.

“After earning my cybersecurity and computer science degree, I want to attend Stony Brook for my bachelor’s degree,” Woronick said, adding, “I’ll decide about a doctorate when I’m more knowledgeable about the field.”

Dan Krivickas, Hampton Bays, Suffolk graduation: May 2022

Krivickas, 20, a 2018 Hampton Bays High School graduate is an Engineering Science major at Suffolk County Community College. “I’ve always been interested in science,” Krivickas said. At BNL he is collaborating on Coherent Electron Cooling and creating three-dimensional computer models from two-dimensional drawings. Krivickas would like to go on to Stony Brook University, New York University or Stevens Institute of Technology in the future. 

“If I could get a position at BNL, it would be the best that I could accomplish,” Krivickas said. “The environment and people are phenomenal and I am excited to be working at the lab. It’s like a dream come true.”

“The programs at Suffolk have been a tremendous help,” he said,  “everything that I learned at Suffolk, translated over to my internship at Brookhaven National Lab.”

Will Daniels, Center Moriches, Suffolk graduation: May 2021

William Daniels

Daniels, 19, a 2019 Center Moriches High School graduate wants to become a professional researcher. At Suffolk, he’s majoring in physics and says “There’s no better way to do that than to work with researchers. I encourage my peers to apply for this internship. It can get you places. I’ve only heard success stories about past interns.” At BNL Daniels is collaborating on High Pressure Rinse Systems for Super Conducting Radio Frequency Cavities

Daniels says that after graduation from Suffolk County Community College he wants to earn a bachelor’s degree at Stony Brook University, majoring in physics.

The first place Great Neck South High School team members, pictured from left, Matthew Tsui, David Wang, Anthony Zhan (team captain), Jansen Wong, Bradley He, and coach James Tuglio pose for a photo after winning first place in 2020.

Great Neck South High School earned the top spot in the Long Island Regional High School Science Bowl hosted by the U.S. Department of Energy’s Brookhaven National Laboratory on Saturday, Jan. 30.  

The winning team faced off virtually against 23 other teams from a total of 18 high schools in the regional competition, part of the DOE National Science Bowl® (NSB). The students tested their knowledge in areas including biology, chemistry, earth and space science, energy, mathematics and physics in the fast-paced question-and-answer tournament.  

The win marks the second consecutive year team members Anthony Zhan, Bradley He, Matthew Tsui, David Wang, and Jansen Wong secured first place for their school. 

“By having the same team for both years, you grow a lot as a team,” said team captain Zhan. “I think a big factor in our success was our team chemistry. We play really well as a team and as a group of friends.” 

For the first time since its establishment in 1991, the competition had to pivot to a virtual format. Teams competed remotely via video chat rooms ran by volunteer moderators, judges, and scorekeepers. After three preliminary rounds, 16 teams advanced to elimination rounds, in which Great Neck South outlasted the rest.

Mary Alexis Pace, coach to second place team The Wheatley School, acknowledged Brookhaven’s Office of Educational Programs (OEP) and volunteers for their hard work in organizing the regional competition.

“I am thankful Brookhaven Lab was able to make this competition work in such a strange year,” Pace said. “I know I speak for all of my students when I say that we truly appreciate the efforts that go into making this event happen.” 

Great Neck South will join the top teams from regional science bowls around the country in the National Science Bowl®, which will be held virtually throughout April and May 2021.  

Second place: Wheatley School–Viraj Jayan, Freddy Lin, Victor Li, and Avinash Reddy 

Third place: Ward Melville High School (team one)–Neal Carpino, Gabriel Choi, Matthew Chen, Ivan Ge, and Prisha Singhal 

Fourth place: Plainegde Senior High School–Aidan Andersen, Luke Andersen, Joseph Devlin, Matthew Garcia, and Tyler Ruvolo 

This year’s event also featured a Cybersecurity Challenge open to all Science Bowl students who did not compete in the final elimination rounds. Students worked individually to solve a cybersecurity-related puzzle and learn about Brookhaven’s cybersecurity efforts. Jacob Leshnower from Half Hollow Hills East took first place, Anant Srinivasan of Commack High School took second place, and Ishnaan Singh of Commack High School took third place.  

More about the Science Bowl  

In the 2021 Long Island Regional Science Bowl organized by Brookhaven Lab, all participating students received a Science Bowl t-shirt. Winning teams also received trophies and medals, and the top four high school teams received cash awards. Prizes were courtesy of Teachers Federal Credit Union and Brookhaven Science Associates (BSA), the event’s sponsors. BSA is the company that manages and operates Brookhaven Lab for DOE. 

The Long Island Regional Science Bowl is one of many educational opportunities organized by Brookhaven’s OEP. Every year, OEP holds science workshops, contests, internships, field trips, and more for students in kindergarten through graduate school. For more information on ways to participate in science education programs at Brookhaven Lab, visit the OEP website

More than 315,000 students have participated in NSB since it was established in 1991, and it is one of the nation’s largest science competitions. The U.S. Department of Energy’s Office of Science manages the NSB Finals competition. More information is available on the NSB website

Brookhaven National Laboratory is supported by the U.S. Department of Energy’s Office of Science. The Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time. For more information, visit https://energy.gov/science.

Follow @BrookhavenLab on Twitter or find us on Facebook.

Valentina Bisogni. Photo from BNL

By Daniel Dunaief

Nature plays a wonderful game of hide-and-seek with its secrets.

One day, Joan might be searching for, say, an apple tree in the forest. Joan might consider all the elements that appeal to an apple tree. She might expect the journey to take two hours but, to her surprise, discovers a tree on the way.

That’s what happened to Valentina Bisogni, a physicist at Brookhaven National Laboratory. Bisogni, who works at the National Synchrotron Lightsource II, wanted to figure out how the thickness in a magnetic film affected traveling modes involving the spin property of electrons, known as spin waves. Specifically, she wanted to control the energy of the spin wave.

This might be important in future devices that involve passing along information through an electron’s spin rather than through charge, which is the current method. Controlling the spin wave could be another way to optimize the performance or improve the efficiency of future devices.

Transmitting charge creates unwanted heat, which can damage the components of an electronic device and limit its usefulness. Heat also creates energy inefficiencies.

Valentina Bisogni with a collection of tomatoes in a garden in Bellport Village. Photo by Claudio Mazoli.

Bisogni, who arrived at BNL in 2014, has been working on a beamline called Soft Inelastic X-ray Scattering, or SIX. Each of the new beamlines at the nearly billion-dollar facility has its own acronym and number that corresponds to their location in the accelerator ring.

Before she planned to apply an electric field that might control the spin wave, however, Bisogni figured she’d explore the way thinner iron materials affected the spin.

That’s when the metaphorical apple tree appeared, as the thickness of iron films, that were as thin as one to 10 nanometers, helped control the spin wave before applying any electric field.

“This result was not expected,” Bisogni said. This was preparatory work to a more detailed, dedicated study. 

“Not having had any benchmark of iron crystals in general with the technique I am using, it was logical to study this system from a bulk/ thin form to a very thin film,” she explained in an email.

Bisogni and a team from Yale University recently published the results of this work in the journal Nature Materials.

While this unexpected result is encouraging and could eventually contribute to the manufacture of electronic devices, Bisogni said this type of discovery helps build a fundamental understanding of the materials and their properties at this size.

“For people assembling or designing devices or wave guides, I think this is an ingredient that has to be considered in the future,” Bisogni said.

This kind of result could enable the optimization of device performance. When manufacturers propagate a signal based on spin dynamics, they would likely want to keep the same frequency, matching the signal along a medium from point A to point B.

The effect of the thickness on the spin was like a power log, which is not quite exponential as the experimenters tested thinner material, she said.

Bisogni plans to continue with this collaboration, as the group is “excellent in preparing and characterizing this kind of system.”

In the bigger picture, Bisogni is focused on quantum materials and altering their spin.

She is also overseeing the development of a system called Opera, which copies the working conditions of electronic devices. Opera is the new sample environment available at SIX and is developed within the research project to copy device-working conditions in the beamline’s measurement chamber.

Bisogni ultimately hopes her work may improve the energy efficiency of electronics.

A resident of Bellport Village, Bisogni lives with her partner Claudio Mazoli, who is the lead scientist for another beamline at the NSLS II, called the Coherent Soft X-ray Scattering, or CSX.

Bisogni said the couple frequently enjoy exchanging ideas and have an ongoing active collaboration, as they share several scientific passions.

The couple met at the European Synchrotron Radiation Facility in Grenoble, France when they were working in the same lab.

Bisogni was born and raised in Spoleto, which is in the province of Perugia in the center of Italy. Bisogni speaks Italian and English as well as French and German after her work experience in France, Germany and Switzerland.

Bisogni said she and Mazoli are “very food-centric” and can find numerous epicurean opportunities in the area of Long Island and New York City. The weather is also similar to home, although they miss their family and friends from Italy.

The couple purchased a house together during the pandemic and have been doing some work to shape the house to their needs. They remodeled the bathrooms in an Italian/ European style, purchased a German washing machine and dryer and painted some walls.

In the summer, Bisogni, who likes to eat, cook and grow vegetables, enjoys spinach, tomatoes and light-green zucchini.

As for her work, Bisogni is currently pleased with the state of her beamline, although she said its development took considerable team effort and time during the development, construction and commissioning.

At this point, her research team includes two and a half permanent scientists and two post-doctoral scientists. Within the team, they have two post-doc researcher positions looking to fill, one for her research project and another dedicated to her colleague’s research project.

Ultimately, Bisogni is excited with the opportunities to make fundamental discoveries at work.

“It is, in general, very exciting, as most likely you are doing something for the first time,” Bisogni explained in an email. “It is true that you may fail, since nobody is going to tell you if what you are doing is going to work or not, but if you get it right, then it is extremely rewarding.”

Qiang Li. Photo courtesy of BNL

By Daniel Dunaief

Decades ago, most people could only tune to shows like The Jetsons to imagine interactive televisions in which people could see each other during conversations.

Qiang Li. Photo courtesy of BNL

In modern times, hand held devices and laptop computers have turned those science fiction ideas into everyday realities, as people can tell their phones to call their mom, to provide the outdoor temperature or to help them recall the name of a movie they saw decades ago.

These helpful technological devices, however, may some day go the way of the clunky desktop computers of yesteryear, as scientists around the world work to turn the vision of a quantum computer into a reality.

Scientists hope to develop a next generation of quantum computer that is faster, smarter, more flexible and more energy-efficient than current technological devices. They hope these devices could be the key to future technological breakthroughs, inspiring them to figure out how to bring the theory to life.

Collaborating with scientists at Ames Laboratory in Iowa, Qiang Li, SUNY Empire Innovation Professor in the Department of Physics and Astronomy at Stony Brook University and Leader of the Advanced Energy Materials Group at Brookhaven National Laboratory, recently published a study in the journal Nature Materials that provided fundamental information that might contribute to the field of quantum computers.

The group of scientists, which included Li’s PhD student Pedro Lozano, discovered a light-induced switch that twists the crystal lattice of a semimetal, turning on an electron current that the team believes is nearly dissipationless.

When currents move through wires between utilities and people’s homes and offices, that current encounters resistance, losing energy along the way, as if the movement towards the home created a tax on the journey. Similarly, dissipation inside an electronic device can sap some of the energy needed to transmit information or a signal, reducing the effectiveness of the process.

Li and BNL physicist Genda Gu synthesized, patterned and characterized the material at BNL, while Jigang Wang, a senior scientist at Ames Laboratory, performed the light-induced lattice twisting. The team helped create the light-induced switch.

Li described the effort as “fundamental research” and cautioned that any such advancement is more of a principal study, rather than a step closer to making any new qubit (the basic unit of quantum information) device.

“This is an experimental study to show that this is possible,” Li said. “It’s a demonstration of feasibility that you can harness chirality for building quantum information systems.”

With chirality, electrons have a handedness based on whether their spin and momentum are aligning in the same or opposite direction.

Once electrons have chirality, they can travel much easier, enabling a more direct and predictable route from one place to another.

Scientists like Li would like to create physical systems that enable them to control the chirality, preventing the spin from switching from one direction to the other.

Numerous factors can disrupt the chirality of an electron, including imperfections in the material.

A pulse-triggered light-induced switch can change the topology of a Weyl semimetal, making it possible to enable the movement of electrons that are nearly dissipationless. “For pure electronics, even computer chips, electrons consume a lot of energy because of electrical resistance,” Li said. “A chiral current [however] will travel without resistance, in ideal cases without chirality flipping.”

Chiral electrons travel through the semimetal at a speed as high as 1/300th of the speed of light and can travel considerably further before a collision that alters its direction, speed, or other particle properties. The mean free path, which is the average distance a particle will travel between such disruptive events, for a typical metal is nanometers. By contrast the chiral electrons can move micrometers, which is thousands of times longer.

An unperturbed chiral electron could travel further distances over shorter intervals, carrying preserved coded information without losing much energy during movement. 

Scientists have sought ways to create a path through which electrons travel with this predictable spin. They can break chiral symmetry by applying a magnetic field, which led to the discovery of the chiral magnetic effect by a team of scientists from BNL and Stony Brook University, including Dmitri Kharzeev, in 2014.  

For this work, Li received the Brookhaven Science and Technology Award in 2019.

“Using a magnetic field is problematic for some computations,” he said. Besides, people don’t want a “big magnet around your computers.”

Another way is to send in the laser pulse, creating left-handed or right-handed polarization.

To determine the ideal pulse to change the material, Li and Wang partnered with several theorists from Ames Lab and Ilias Perakis, Professor and Chair of Physics at the University of Alabama — Birmingham.

The theorists conducted detailed analysis of the lattice vibrations and the ideal pulse energy needed to break symmetry in the Weyl semimetal. “There is a very strong collaboration between the theorists and the experimentalists,” Li said.

While the research remains fundamental and is unlikely to generate a specific product any time soon, Li said it has “attracted a lot of attention” from other scientists and is a significant step forward in establishing the basic principles for topology-enabled quantum logic and information systems.

Li and Wang have been collaborating on this project for about two years as scientists around the world are in a “horse race” to produce results in the arena of quantum computing.

A resident of Setauket, Li and his wife Meiling Shih, have two children. Shih, who worked in the Stony Brook Pharmacological Science Department and later at Morgan Stanley, is retired and is now a volunteer instructor of a Tai Chi class for local seniors, 

Li enjoys jogging and runs a few miles every other day.

Down the road, Li hopes to address how to make the two quantum bits talk to each other.

Results from a study of clouds and aerosols conducted in the Azores revealed that new particles can seed the formation of clouds in the marine boundary layer—the atmosphere up to about a kilometer above Earth's surface—even over the open ocean, where the concentration of precursor gases was expected to be low. Image courtesy of the U.S. Department of Energy Atmospheric Radiation Measurement (ARM) user facility.

Understanding previously undocumented source of new particle formation will improve models of aerosols, clouds, and their impact on Earth’s climate

New results from an atmospheric study over the Eastern North Atlantic reveal that tiny aerosol particles that seed the formation of clouds can form out of next to nothingness over the open ocean. This “new particle formation” occurs when sunlight reacts with molecules of trace gases in the marine boundary layer, the atmosphere within about the first kilometer above Earth’s surface. The findings, published in the journal Nature Communications, will improve how aerosols and clouds are represented in models that describe Earth’s climate so scientists can understand how the particles—and the processes that control them—might have affected the planet’s past and present, and make better predictions about the future.

“When we say ‘new particle formation,’ we’re talking about individual gas molecules, sometimes just a few atoms in size, reacting with sunlight,” said study co-author Chongai Kuang, a member of the Environmental and Climate Sciences Department at the U.S. Department of Energy’s Brookhaven National Laboratory. “It’s interesting to think about how something of that scale can have such an impact on our climate—on how much energy gets reflected or trapped in our atmosphere,” he said.

Using an aircraft outfitted with 55 atmospheric instrument systems, scientists traversed horizontal tracks above and through clouds and spiraled down through atmospheric layers to provide detailed measurements of aerosols and cloud properties. The aircraft data were supplemented by measurements made by ground-based radars and other instruments. Image courtesy of the U.S. Department of Energy Atmospheric Radiation Measurement (ARM) user facility.

But modeling the details of how aerosol particles form and grow, and how water molecules condense on them to become cloud droplets and clouds, while taking into consideration how different aerosol properties (e.g., their size, number, and spatial distribution) affect those processes is extremely complex—especially if you don’t know where all the aerosols are coming from. So a team of scientists from Brookhaven and collaborators in atmospheric research around the world set out to collect data in a relatively pristine ocean environment. In that setting, they expected the concentration of trace gases to be low and the formation of clouds to be particularly sensitive to aerosol properties—an ideal “laboratory” for disentangling the complex interactions.

“This was an experiment that really leveraged broad and collaborative expertise at Brookhaven in aerosol observations and cloud observations,” Kuang said. Three of the lead researchers—lead authors Guangjie Zheng and Yang Wang, and Jian Wang, principal investigator of the Aerosol and Cloud Experiments in the Eastern North Atlantic [https://www.arm.gov/publications/backgrounders/docs/doe-sc-arm-16-020.pdf] (ACE-ENA) campaign—began their involvement with the project while working at Brookhaven and have remained close collaborators with the Lab since moving to Washington University in St. Louis in 2018.

Land and sea

Brookhaven Lab atmospheric scientist Chongai Kuang (center) with Art Sedlacek (left) and Stephen Springston (right) aboard ARM’s Gulfstream-159 (G-1) aircraft during a 2010 atmospheric sampling mission that was not part of this study. Image courtesy of the U.S. Department of Energy Atmospheric Radiation Measurement (ARM) user facility.

The study made use of a long-term ground-based sampling station on Graciosa Island in the Azores (an archipelago 850 miles west of continental Portugal) and a Gulfstream-1 aircraft outfitted with 55 atmospheric instrument systems to take measurements at different altitudes over the island and out at sea. Both the ground station and aircraft belong to the DOE Office of Science’s Atmospheric Radiation Measurement (ARM) user facility [https://www.arm.gov/], managed and operated by a consortium of nine DOE national laboratories.

The team flew the aircraft on “porpoise flights,” ascending and descending through the boundary layer to get vertical profiles of the particles and precursor gas molecules present at different altitudes. And they coordinated these flights with measurements taken from the ground station.

The scientists hadn’t expected new particle formation to be happening in the boundary layer in this environment because they expected the concentration of the critical precursor trace gases would be too low.

“But there were particles that we measured at the surface that were larger than newly formed particles, and we just didn’t know where they came from,” Kuang said.

The aircraft measurements gave them their answer.

Many of the choreographed flight paths for this study traversed the open ocean and also crossed within the ranges of the ground-based scanning radars at DOE’s Atmospheric Radiation Measurement (ARM) Climate Research Facility on Graciosa Island in the Azores. Image courtesy of the U.S. Department of Energy Atmospheric Radiation Measurement (ARM) user facility.

“This aircraft had very specific flight patterns during the measurement campaign,” Kuang said. “They saw evidence that new particle formation was happening aloft—not at the surface but in the upper boundary layer.” The evidence included a combination of elevated concentrations of small particles, low concentrations of pre-existing aerosol surface area, and clear signs that reactive trace gases such as dimethyl sulfide were being transported vertically—along with atmospheric conditions favorable for those gases to react with sunlight.

“Then, once these aerosol particles form, they attract additional gas molecules, which condense and cause the particles to grow to around 80-90 nanometers in diameter. These larger particles then get transported downward—and that’s what we’re measuring at the surface,” Kuang said.

“The surface measurements plus the aircraft measurements give us a really good spatial sense of the aerosol processes that are happening,” he noted.

At a certain size, the particles grow large enough to attract water vapor, which condenses to form cloud droplets, and eventually clouds.

Both the individual aerosol particles suspended in the atmosphere and the clouds they ultimately form can reflect and/or absorb sunlight and affect Earth’s temperature, Kuang explained.

Study implications

Framed by a brilliant rainbow, ARM’s Gulfstream-159 (G-1) research aircraft sits on the tarmac on Terceira Island during the Aerosol and Cloud Experiments in the Eastern North Atlantic (ACE-ENA) winter 2018 intensive operation period in the Azores. Image courtesy of the U.S. Department of Energy Atmospheric Radiation Measurement (ARM) user facility.

So now that the scientists know new aerosol particles are forming over the open ocean, what can they do with that information?

“We’ll take this knowledge of what is happening and make sure this process is captured in simulations of Earth’s climate system,” Kuang said.

Another important question: “If this is such a clean environment, then where are all these precursor gases coming from?” Kuang asked. “There are some important precursor gases generated by biological activity in the ocean (e.g., dimethyl sulfide) that may also lead to new particle formation. That can be a nice follow-on study to this one—exploring those sources.”

Understanding the fate of biogenic gases such as dimethyl sulfide, which is a very important source of sulfur in the atmosphere, is key to improving scientists’ ability to predict how changes in ocean productivity will affect aerosol formation and, by extension, climate.

The research was funded by the DOE Office of Science, DOE’s Atmospheric System Research, and by NASA. In addition to the researchers from Brookhaven Lab and Washington University, the collaboration included scientists from Pacific Northwest National Laboratory; Missouri University of Science and Technology; the University of Washington, Seattle; NASA Langley Research Center; Science Systems and Applications Inc. in Hampton, Virginia; the Max Planck Institute for Chemistry in Mainz, Germany; and the Scripps Institution of Oceanography, University of California, San Diego.

Brookhaven National Laboratory is supported by the Office of Science of the U.S. Department of Energy.  The Office of Science is the single largest supporter of basic research in the physical sciences in the United States, and is working to address some of the most pressing challenges of our time.  For more information, please visit science.energy.gov [https://www.energy.gov/science/office-science].

Accelerator physicist Chuyu Liu, the run coordinator for this year's experiments at the Relativistic Heavy Ion Collider (RHIC), in the Main Control Room of the collider-accelerator complex at Brookhaven National Laboratory.

Final stage of Beam Energy Scan II will collect low-energy collision data needed to understand the transition of ordinary nuclear matter into a soup of free quarks and gluons

Accelerator physicists are preparing the Relativistic Heavy Ion Collider (RHIC), a DOE Office of Science user facility for nuclear physics research at DOE’s Brookhaven National Laboratory, for its 21st year of experiments, set to begin on or about February 3. Instead of producing high-energy particle smashups, the goal for this run is to maximize collision rates at the lowest energy ever achieved at RHIC.

STAR co-spokesperson Lijuan Ruan noted that this year’s run is the third and final leg of Beam Energy Scan II, a systematic study of RHIC collisions at low energies.

“Run 21 is the final step of Beam Energy Scan II (BES-II), a three-year systematic study of what happens when gold ions—gold atoms stripped of their electrons—collide at various low energies,” said Brookhaven physicist Lijuan Ruan, co-spokesperson for RHIC’s STAR experiment collaboration.

Nuclear physicists will examine the BES-II data, along with data from RHIC’s high-energy collisions, to map out how these collisions transform ordinary protons and neutrons into an extraordinary soup of free quarks and gluons—a substance that mimics what the early universe was like some 14 billion years ago. By turning the collision energy down, RHIC physicists can change the temperature and other variables to study how these conditions affect the transition from ordinary matter to early-universe hot quark-and-gluon soup.

“Out of the five energies of BES-II—9.8, 7.3, 5.75, 4.6, and 3.85 billion electron volts, or GeV—this year’s run at 3.85 GeV is the most difficult one,” said Brookhaven Lab accelerator physicist Chuyu Liu, the run coordinator. That’s because “RHIC’s beams of gold ions are really difficult to hold together at the lowest energy,” he explained.

In Run 21, the accelerator team will use a variety of innovative components and schemes to maintain the lifetime and intensity of the colliding ion beams under challenging conditions. Read on to learn more about RHIC’s Run 21 science goals and the accelerator features that will make the science possible.

Scanning the transition

Mapping nuclear phase changes is like studying how water changes under different conditions of temperature and pressure (net baryon density for nuclear matter). RHIC’s collisions “melt” protons and neutrons to create quark-gluon plasma (QGP). STAR physicists are exploring collisions at different energies, turning the “knobs” of temperature and baryon density, to look for signs of a “critical point.” That’s a set of conditions where the type of transition between ordinary nuclear matter and QGP changes from a smooth crossover observed at RHIC’s highest energies (gradual melting) to an abrupt “first order” phase change that’s more like water boiling in a pot.

As Ruan explained, the quest to map out the phases of nuclear matter and the transitions between them is somewhat similar to studying how water molecules transform from solid ice to liquid water and gaseous steam at different temperatures and pressures. But nuclear matter is trickier to study.

“We need a powerful particle collider and sophisticated detector systems to create and study the most extreme forms of nuclear matter,” she said. “Thanks to the incredible versatility of RHIC, we can use the ‘knob’ of collision energy and the intricate particle-tracking capabilities of the STAR detector to conduct this systematic study.”

RHIC’s highest collision energies (up to 200 GeV) produce temperatures more than 250,000 times hotter than the center of the Sun. Those collisions “melt” the protons and neutrons that make up gold atoms’ nuclei, creating an exotic phase of nuclear matter called a quark-gluon plasma (QGP). In QGP, quarks and gluons are “free” from their ordinary confinement within protons and neutrons, and they flow with virtually no resistance—like a nearly perfect liquid.

But QGP lasts a mere fraction of a second before “freezing out” to form new particles. RHIC physicists piece together details of how the melting and refreezing happen by taking “snapshots” of the particles that stream out of these collisions.

By systematically lowering the collision energy, the physicists are looking for signs of a so-called “critical point.” This would be a set of conditions where the type of transition between ordinary nuclear matter and QGP changes from the smooth crossover observed at RHIC’s highest energies (picture butter melting gradually on a counter), to an abrupt “first order” phase change (think of how water boils suddenly at a certain temperature and holds that temperature until all the molecules evaporate).

As physicists turn RHIC’s collision energy down, they expect to see large event-by-event fluctuations in certain measurements—similar to the turbulence an airplane experiences when entering a bank of clouds—as conditions approach a “critical point” in the nuclear phase transition. This year’s run at the lowest collision energy will contribute to this search.

“Theorists have predicted that certain key measurements at RHIC will exhibit dramatic event-by-event fluctuations when we approach this critical point,” Ruan said.

Some RHIC physicists liken these fluctuations to the turbulence an airplane experiences when it moves from smooth air into a bank of clouds and then back out again. Measurements from phase I of RHIC’s Beam Energy Scan (BES-I, with data collected between 2010 and 2017) revealed tantalizing hints of such turbulence. But because collisions are hard to achieve at low energies, the data from BES-I aren’t strong enough to draw definitive conclusions.

Now, in BES-II, a host of accelerator improvements have been implemented to maximize low-energy collision rates.

Cooling the ions

One of the innovations that Chuyu Liu and the other Collider-Accelerator Department (C-AD) physicists managing RHIC operations will take advantage of in Run 21 is a first-of-its-kind beam-cooling system. This Low Energy RHIC electron Cooling  (LEReC) system operated at full capacity for the first time in last year’s RHIC run, making it the world’s first implementation of electron cooling in a collider. But it will be even more important for the lowest-of-low collision energies this year.

“The longer the beam stays at low energy, the more ‘intra-beam scattering’ and ‘space charge’ effects degrade the beam quality, reducing the number of circulating ions,” said Liu. Simplistic translation: The positively charged ions tend to repel one another. (Remember: The ions are atoms of gold stripped of their electrons, leaving a lot of net positive charge from the 79 protons in the nucleus.) The scattering and the repulsive space charge cause the ions to spread out, essentially heating up the beam as it makes its way around the 2.4-mile-circumference RHIC accelerator. And spread-out ions are less likely to collide.

A host of accelerator improvements have been implemented to maximize RHIC’s low-energy collision rates. These include a series of components that inject a stream of cool electron bunches into the ion beams in these cooling sections of the two RHIC rings. The cool electrons extract heat to counteract the tendency of RHIC’s ions to spread out, thereby maximizing the chances the ions will collide when the beams cross at the center of RHIC’s STAR detector.

“The LEReC system operates somewhat similar to the way the liquid running through your home refrigerator extracts heat to keep your food cool,” said Wolfram Fischer, Associate Chair for Accelerators in C-AD, “but the technology needed to achieve this beam cooling is quite a bit more complicated.”

A series of components (special lasers and a photocathode gun) produces bunches of relatively cool electrons, which are accelerated to match the bunching and near-light-speed pace of RHIC’s ions. Transfer lines inject the cool electrons into the stream of ion bunches—first in one RHIC ring, then, after making a 180-degree turn, into the other. As the particles mix, the electrons extract heat, effectively squeezing the spread-out ion bunches back together. The warmed-up electron bunches then get dumped and replaced with a new cool batch.

“To add more flexibility for cooling optimization during this year’s run at RHIC’s lowest energy, where the space-charge effects and beam lifetime degradation are concerns for both the electrons and the ions, we installed a new ‘second harmonic’ radiofrequency (RF) cavity in the electron accelerator,” said Alexei Fedotov, the accelerator physicist who led the LEReC project.

These cavities generate the radio waves that push the electrons along their path, with the higher (second harmonic) frequency helping to flatten out the longitudinal profile of the electron bunches. “This should help to reduce the space charge effect in the electron beams to achieve better cooling performance at low energy,” Fedotov said.

“We plan to commission the new electron beam transport line in late January and start cooling ions with the new electron beam setup in early February,” he added.

More accelerator advances

Similarly, third-harmonic RF cavities installed in the ion accelerator rings will help to flatten the longitudinal profile of the ion bunches, reducing their peak intensity and space charges, Liu explained. “With that, more bunch intensity can be injected into RHIC to produce higher luminosity—a measure closely tied to collision rates,” he said.

The accelerator team will also be commissioning a new bunch-by-bunch feedback system to help stabilize the beam for a better lifetime. “This system measures how each ion bunch deviates from the center of the beam pipe, and then applies a proportional correction signal through a component called a kicker to nudge each bunch back to where it should be,” Liu said.

All this cooling and nudging will counteract the ions’ tendency to spread, which maximizes chances of collisions happening when the two beams cross at the center of STAR.

“This run will bring together many of the advances we’ve been working on at RHIC to meet the challenging conditions of low-energy collisions,” said Fischer. “STAR would have preferred to test the lowest energy first, but we needed to learn everything possible (and develop the electron cooling system) before we could embark on operation at the most difficult energy.”

RHIC operations are funded by the DOE Office of Science.

Brookhaven National Laboratory is supported by the U.S. Department of Energy’s Office of Science. The Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time. For more information, visit https://www.energy.gov/science/ [https://www.energy.gov/science/].

Brookhaven Lab Scientist Guobin Hu loaded the samples sent from researchers at Baylor College of Medicine into the new cryo-EM at LBMS. Photo from BNL

On January 8 the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory welcomed the first virtually visiting researchers to the Laboratory for BioMolecular Structure (LBMS), a new cryo-electron microscopy facility. DOE’s Office of Science funds operations at this new national resource, while funding for the initial construction and instrument costs was provided by NY State. This state-of-the-art research center for life sciences imaging offers researchers access to advanced cryo-electron microscopes (cryo-EM) for studying complex proteins as well as the architecture of cells and tissues.

Many modern advances in biology, medicine, and biotechnology were made possible by researchers learning how biological structures such as proteins, tissues, and cells interact with each other. But to truly reveal their function as well as the role they play in diseases, scientists need to visualize these structures at the atomic level. By creating high-resolution images of biological structure using cryo-EMs, researchers can accelerate advances in many fields including drug discovery, biofuel development, and medical treatments.

During the measurement of the samples, the LBMS team interacted with the scientists from Baylor College of Medicine through Zoom to coordinate the research. Photo from BNL

This first group of researchers from Baylor College of Medicine used the high-end instruments at LBMS to investigate the structure of solute transporters. These transporters are proteins that help with many biological functions in humans, such as absorbing nutrients in the digestive system or maintaining excitability of neurons in the nervous system. This makes them critical for drug design since they are validated drug targets and many of them also mediate drug uptake or export. By revealing their structure, the researchers gain more understanding for the functions and mechanisms of the transporters, which can improve drug design.  The Baylor College researchers gained access to the cryo-EMs at LBMS through a simple proposal process.

“Our experience at LBMS has been excellent. The facility has been very considerate in minimizing user effort in submission of the applications, scheduling of microscope time, and data collection,” said Ming Zhou, Professor in the Department of Biochemistry of Molecular Biology at Baylor College of Medicine.

All researchers from academia and industry can request free access to the LBMS instruments and collaborate with the LBMS’ expert staff.

“By allowing science-driven use of our instruments, we will meet the urgent need to advance the molecular understanding of biological processes, enabling deeper insight for bio-engineering the properties of plants and microbes or for understanding disease,” said Liguo Wang, Scientific Operations Director of the LBMS. “We are very excited to welcome our first visiting researchers for their remote experiment time. The researchers received time at our instruments through a call for general research proposals at the end of August 2020. Since September, we have been running the instruments only for COVID-19-related work and commissioning.”

LBMS has two cryo-electron microscopes—funded by $15 million from NY State’s Empire State Development—and the facility has space for additional microscopes to enhance its capabilities in the future. In recognition of NY State’s partnership on the project and to bring the spirit of New York to the center, each laboratory room is associated with a different iconic New York State landmark, including the Statue of Liberty, the Empire State Building, the Stonewall National Monument, and the Adam Clayton Powell Jr. State Office Building.

“By dedicating our different instruments to New York landmarks, we wanted to acknowledge the role the State played in this new national resource and its own unique identity within Brookhaven Lab,” said Sean McSweeney, LBMS Director. “Brookhaven Lab has a number of facilities offering scientific capabilities to researchers from both industry and academia. In our case, we purposefully built our center next to the National Synchrotron Light Source II, which also serves the life science research community. We hope that this co-location will promote interactions and synergy between scientists for exchanging ideas on improving performance of both facilities.”

Brookhaven’s National Synchrotron Light Source II (NSLS-II) is a DOE Office of Science User Facility and one of the most advanced synchrotron light sources in the world. NSLS-II enables scientists from academia and industry to tackle the most important challenges in quantum materials, energy storage and conversion, condensed matter and materials physics, chemistry, life sciences, and more by offering extremely bright light, ranging from infrared light to x-rays. The vibrant structural biology and bio-imaging community at NSLS-II offers many complementary techniques for studying a wide variety of biological samples.

“At NSLS-II, we build strong partnership with our sister facilities, and we are looking forward to working closely with our colleagues at LBMS. For our users, this partnership will offer them access to expert staff at both facilities as well as to a versatile set of complementary techniques,” said NSLS-II Director John Hill. “NSLS-II has a suite of highly automated x-ray crystallography and solution scattering beamlines as well as imaging beamlines with world-leading spatial resolution. All these beamlines offer comprehensive techniques to further our understanding of biological system. Looking to the future, we expect to combine other x-ray techniques with the cryo-EM data to provide unprecedented information on the structure and dynamics of the engines of life.”

LBMS operations are funded by the U.S. Department of Energy’s Office of Science. NSLS-II is a DOE Office of Science user facility.

Brookhaven National Laboratory is supported by the U.S. Department of Energy’s Office of Science. The Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time. For more information, visit https://energy.gov/science.

Veronica Sanders. Photo from BNL

By Daniel Dunaief

If doctors could somehow stick numerous miniature flashlights in human bodies and see beneficial or harmful reactions, they would be able to diagnose and treat people who came into their offices.

That’s what Vanessa Sanders, Assistant Scientist at Brookhaven National Laboratory, is working to develop, although instead of using a flashlight, she and her colleagues are using radioisotopes of elements like arsenic. Yes, arsenic, the same element at the center of numerous murder mysteries, has helpful properties and, at low enough concentrations, doesn’t present health threats or problems.

Arsenic 72 is useful in the field of theranostics, which, as the name suggests, is a combination of therapeutics and diagnostics.

Isotopes “allow us to observe visual defects and through using these radioactive agents, we can also observe the functionality of organs,” Sanders explained in an email. These agents can assist in diagnosing people, which can inform the treatment for patients.

What makes arsenic 72 and other radioisotopes helpful is that they have a longer half-life than other isotopes, like fluorine 18, which only lasts for several minutes before it decays. Arsenic-72 has a half life of 26 hours, which matches with the life of an antibody, which circulates through bodies, searching for targets for the immune system. The combination of arsenic-72 and arsenic-77 allows the former to act as a diagnostic agent and the later as a therapeutic partner.

By attaching this radioisotope to antibodies of interest, scientists and doctors can use the decay of the element as a homing device. Using Positron Emission Tomography, agents allow for the reconstruction of images based on the location of detected events.

“When you want to use an antibody as a target for imaging, you want an isotope that will be able to ride with the antibody and accumulate at an area of interest,” Sanders said.

A radiochemist, Sanders is working to develop systems that help researchers and doctors diagnose the extent of problems, while also tracking progress in fighting against diseases. She is working to produce arsenic-72 through the decay of selenium-72.

Using the Brookhaven Linac Isotope Producer, scientists produce selenium-72. They then create a generator system where the selenium 72 is absorbed onto a solid substrate. As it decays, the solid substrate is washed to obtain arsenic-72.

Sanders is hoping to create a device that researchers could ship to clinical institutions where institutions could use arsenic-72 in further applications.

The system BNL is creating is a research and development project. Sanders and her colleagues are working to optimize the process of producing selenium-72 and evaluating how well the selenium, which has a half life of eight days, is retained and how much they can load onto generators.

“We want [arsenic 72] in a form that can easily go into future formulations,” Sanders said. “When we rinse it off that column, we hope to quickly use it and attach it to biomolecules, antibodies or proteins and use it in a biological system.”

With the increasing prevalence of personalized approaches to diseases, Sanders explained that the goal with these diagnostic tools is to differentiate the specific subtype.

A person with pancreatic cancer, for example, might present a specific target in high yield, while another patient might have the same stage cancer without the same high yield target.

“We want to have different varieties or different options of these diagnostic tools to be able to tailor it to the individual patient,” explained Sanders.

Cathy Cutler, Director of the Medical Isotope Program at BNL, said the isotopes Sanders is working on “have a lot of promise” and are “novel.” She described Sanders as “very organized” and “very much a go-getter.”

Cutler said the department feels “very lucky to get her and have her in the program.”

In her group, Sanders explained that she and her colleagues are eager to develop as many radioisotopes as possible to attach them to biomolecules, which will enable them to evaluate disease models under different scenarios. Other researchers are working with arsenic-77, which acts as a therapeutic agent because it emits a different particle.

Scientists are working on a combination of radioisotopes that can incorporate diagnostic and therapeutic particles. When the arsenic 77 destroys the cells by breaking the DNA genetic code, researchers could still observe a reduction in a tumor size. Depending on the disease type and the receptor targeted, scientists could notice a change by observing less signal.

Sanders is working on attaching several radioisotopes to biomolecules and evaluating them to see how well they are produced and separated.

“We make sure [the isotope] attaches to the thing it’s supposed to stick to” such as an antibody, she said.

A resident of Sound Beach, Sanders grew up in Cocoa, which is in central Florida. When she was younger, she wanted to be a trauma surgeon, but she transitioned to radioisotopes when she was in college at Florida Memorial University. “I liked the problem solving aspect of chemistry,” she said. While she works with cancer, she said she would like to investigate neurological diseases as well.

Sanders, who has been living on Long Island since 2017 when she started her post doctoral work at BNL, enjoys the quieter, suburban similarities between the island and her earlier life in Florida.

At six feet, one and a half inches tall, Sanders enjoys playing center on basketball teams and, prior to the pandemic, had been part of several adult leagues in the city and on Long Island, including Ladies Who Hoop and LI Hoops. She is also involved in a sorority, Zeta Phi Beta Sorority Inc, that contributes to community service efforts.

Sanders and her fiancee Joshua Morancie, who works in IT support, had planned to get married in July. They set a new date in the same month next year. If the pandemic continues to derail their party plans next year, the couple plan to wed in a smaller ceremony.

As for radioisotopes, Sanders hopes people become inspired by the opportunities radioisotopes provide for science and medicine.

“There are so many good things that come out of radioisotopes,” Sanders said. “There are so many promising advantages.”