Three months after a fire engulfed one of the buildings that makes up the Setauket Commons former tenants are embarking on new paths.

Business were forced to close after a fire ripped through 60 Route 25A in Setauket, the night of Oct. 7. The fire took more than two hours to control, according to Setauket Fire Department, leaving smoke and water damage in its wake.

Veterinarian Dr. Anthony Nanton, owner of Brookhaven Cat Hospital, has been working at Paumanok Veterinary Hospital in Patchogue since the end of November. The Stony Brook resident said when he arrived on the scene Oct. 7 smoke was pouring out of the building. It’s still difficult for him to talk about that night.

“It was quite traumatic,” he said.

Nanton said three resident cats died in the fire from what appeared to be smoke inhalation. The animal hospital was the felines’ home since 2003 when it was located in Coram.

“They were like my children,” the veterinarian said.

While Nanton will now work out of Patchogue, Anne McLaughlin, president of Hayes Physical Therapy, said she and her staff will remain in Setauket. The business has operated out of the Setauket Commons since 2004 and McLaughlin bought the company in 2009.

Since the fire, McLaughlin has made house calls when she can and referred patients to her colleagues in the surrounding area.

McLaughlin said she signed a new lease Jan. 11, and Hayes Physical Therapy will be moving to the same shopping center as Mario’s Italian Restaurant — Heritage Corners East — in the storefront of the former music store. She is hoping to reopen within the next couple of weeks.

“There was no question that I was going to stay in the Three Village area,” she said. “It was just a matter of finding a suitable location.”

The employees of Advanced Research Media, which had an office in the building for 2 1/2 years, are now working remotely from their homes, according to the company’s vice president Elyse Blechman. The owners of Healing Massage could not be reached by this publication’s press time.