Metabolic aging of your cells may accelerate with lack of sleep
If you’ve ever felt sleep deprived, this article is for you. Fatigue is a common patient complaint, and there is a long list of maladies that may be responsible: sleep deprivation, infectious diseases (such as Lyme) and hypothyroidism (low thyroid functioning), to name a few.
We are going to focus on sleep deprivation, since it may impact our quality of life, influencing weight gain, disorders involving insulin resistance, kidney function and cognition, as well as chronic diseases, like diabetes. Even a short duration of inadequate sleep can have a surprising impact.
How much sleep do we need? Conventional wisdom has always been eight hours (Sleep. 1995;18:908). However, it varies depending on the individual. About 26% of Americans get eight or more hours of sleep per night (National Sleep Foundation, 2005). During the work week, approximately 30% of individuals in the U.S. get fewer than six hours of sleep.
The evidence suggests that, when you get to five hours or fewer per night, most people get into trouble.
In a recent, small prospective (forward-looking) study, results show that sleep deprivation results in weight-gain. Why is this? You actually burn more calories (about 5% more) when you sleep fewer hours, but you consume significantly more calories than you metabolize (Proc Natl Acad Sci USA. 2013;110:5695-5700). The individuals who were sleep-restricted gained about two pounds. That may not sound like much but the scary part is it occurred over a short time period — one work week, or five days.
Study participants were in a controlled setting, with half of them restricted to five hours of sleep and half of them permitted to sleep up to nine hours. Everyone was given access to ample amounts of food. Interestingly, not only did the amount of food consumed by those who were sleep deprived increase, but carbohydrate consumption became dominant. When participants who had been sleep deprived were transitioning toward adequate sleep in the second week, they began to make better food choices and started to lose weight.
In addition, researchers found that natural melatonin levels are altered by sleep deprivation, resulting in a change in our circadian rhythms or biological clocks that make it harder to fall asleep.
In another study, the results were similar (Sleep. 2013;36:981-990). This one involved 225 healthy participants. Those who were sleep restricted gained ironically about two pounds of weight over five days. Just like the previous study, participants were in a controlled laboratory where food was provided and their sleep monitored. In both studies, significant late night eating was common.
In a Nurses’ Health Study, results show that, for participants who regularly slept five hours or fewer, there was a 32% increased risk of gaining more than 30 pounds (Am. J. Epidemiol. 2006;164:947-954). This observational study involved approximately 68,000 women and was 16 years in duration.
Effects on aging
In a very small, but well-designed, randomized prospective study, adipocytes (fat cells) in sleep-deprived individuals became resistant or insensitive to ever-higher levels of insulin (Ann Intern Med. 2012;157:549-557). This may be a precursor to increased risk of weight gain and diabetes. The sleep-deprived participants were allowed four-and-a-half hours of sleep per night over a period of four days compared to the control group, which was allowed eight-and-a-half hours per night. The most surprising effect found was that the fat cells of sleep deprived individuals aged approximately two decades metabolically, so that participants in their 20s had fat cells that functioned similar to those in their 40s.
In the Millennium Cohort Study, participants with inadequate sleep were at significantly greater risk of developing type 2 diabetes than those with sufficient sleep (Diabetes Care Online. July 2013). In fact, participants who had five hours of sleep per night were at a 28% increased risk, and those who had fewer than five hours a night had a 52% greater risk. Adequate sleep was defined as at least seven hours. This was a prospective (forward-looking) observational study involving over 47,000 military personnel. The researchers brought up a good point: while sleep is on the decline, diabetes has been on the rise over the last three decades.
Sleep deprivation’s impact on cognition may be immediate. In a study, healthy participants were subjected to sleep deprivation that resulted in decreased neurobehavorial functioning, or cognition, when compared to controls (Sleep. 2010;33:1013-1026). Those in the sleep-deprivation group were restricted for five days to four hours per night in bed, while those in the control group were allowed 10 hours per night. The sleep-deprived group was then allowed one night of 10 hours of sleep. While they recovered some neurobehavorial functioning, they didn’t reach their previous baseline levels. This study simulated the work week followed by one day of recovery. The study was an in-laboratory, well-controlled study involving 159 healthy participants.
In the Familial Adult Children Study (FACS), presented at the prestigious 64th Annual American Academy of Neurology Meeting, participants with poor quality sleep were more likely to have high levels of amyloid beta plaques (AAN Abstract 703). The significance of these plaques is that they may be precursors to Alzheimer’s disease. The researchers discovered that participants who woke five times in each hour of sleep had a substantially greater risk of developing amyloid beta plaques. Thus, those with lesser sleep efficiency were more likely to have preclinical Alzheimer’s disease. None of the patients showed any symptomatic cognitive deficits, only early preclinical signs of Alzheimer’s. This is a very preliminary study that requires further prospective and randomized clinical trials.
At this point, we can agree that sleep deprivation is something to be taken seriously. If you are fatigued, it may not be a bad idea to have your glucose (sugars) checked. Also, getting sufficient sleep may help slow the metabolic aging of your cells — and most of us want to forestall the aging process. As we age, cognition is a central issue. If we can decrease our risk of cognitive decline while aging, this is an ideal scenario. So, make sure you are getting good quality and quantity of sleep that fits your individual needs. It is not just an inconvenience to be tired, it actually affects your health.
Dr. Dunaief is a speaker, author and local lifestyle medicine physician focusing on the integration of medicine, nutrition, fitness and stress management. For further information, go to the website www.medicalcompassmd.com and/or consult your personal physician.