Tags Posts tagged with "Cancer"

Cancer

Dave Tuveson. Photo by Gina Motisi/CSHL

By Daniel Dunaief

While one bad apple might spoil the bunch, the same might be true of one bad cancer gene.

Cold Spring Harbor Laboratory’s Cancer Director Dave Tuveson and Derek Cheng, who earned his PhD from Stony Brook University while conducting research in Tuveson’s lab, recently explored how some mutant forms of genes in pancreatic cancer can involve other proteins that also promote cancer.

A gene well-researched in Tuveson’s lab, mutated KRAS promotes cell division. Mutant versions of this gene continue to produce copies of themselves, contributing to cancer.

Derek Cheng

Turning off or blocking this gene, however, doesn’t solve the problem, at least not in the laboratory models that track a cancer cell’s response.

In laboratory models of pancreatic cancer, a disease for which the prognosis is often challenging, other proteins play a role, creating what researchers call an “adaptive resistance” to chemotherapy.

In a paper published in the journal Proceedings of the National Academy of Sciences, Cheng, who is the first author and is currently in his final year of medical school at the Stony Brook Renaissance School of Medicine, and Tuveson showed that a protein called RSK1 interacts at the membrane with mutated KRAS. When KRAS is inhibited, the RSK1 protein, which normally keeps RAS proteins dormant, becomes more active.

“If you antagonize KRAS, you would get a rebound” as the cancer cells develop a resistance to the original drug, Tuveson said. “We found a feedback loop.”

The research “focused on identifying protein complexes with oncogenic KRAS that would potentially be relevant in pancreatic cancer,” Cheng explained in an email. “My work suggests that an RSK1/NF1 complex exists in the vicinity of oncogenic KRAS.”

While Cheng was able to show that the role of membrane-localized RSK1 provided negative regulation of wild-type RAS, it “remains to be studied what the role of the RSK1 at the membrane [is] in the context of oncogenic KRAS.”

KRAS is a molecular switch that turns on and off with the help of other proteins. With certain mutations, the switch doesn’t turn off, continuing to signal for copying and dividing, which are hallmarks of cancer cells. With specific activating mutations, the switch can lose its ability to turn off and constitutively signal for proliferation, metabolic reprogramming, and other behaviors characteristic of cancer cells, Cheng explained.

A cell with an oncogenic KRAS has the tendency to be more fit than a normal cell without one. Such cells will likely grow at a faster rate under stressful conditions, which, over time, can enable them to outcompete normal cells, Cheng continued.

When KRAS is in an oncogenic state, another protein, called RSK1 is hanging around the membrane. RSK1 has several functions and can participate in numerous cellular signaling pathways.

KRAS cytoplasm

While RSK1 is involved in protein translation by phosphorylating S6 kinase, it also has other functions at the plasma membrane, where it shuts down wild type RAS proteins.

Other researchers have suggested a negative feedback for RSK1 and NF1.

“Our contribution demonstrated some relevance of this interaction in pancreatic cancer cells,” Cheng explained in an email.

Cheng said RSK is known to have various effects, depending on the context. In the paper, the scientists showed that RSK has a “negative feedback properties, such as that, upon the removal of mutant KRAS, it has this negative regulatory role.”

Graduate student Sun Kim and post doctoral researchers Hsiu-Chi Ting and Jonathan Kastan are currently exploring whether RSK has a pro-oncogenic function on the membrane in the tumor cell.

So far, these studies suggest that while a direct inhibitor against oncogenic KRAS would likely be the greatest target for an effective therapy, cancer cells may still be able to use signals from other RAS isoforms.

“A combination of targeting KRAS and modulating regulators of RAS such as RSK1/NF1 and SOS1 may enhance therapeutic efficacy,” Cheng suggested.

Cheng is grateful for the opportunity to learn from numerous Tuveson lab members on ways cancer cells differ from healthy cells.

The discovery of the potential roles of RSK1 in cancer provides some possible explanation for the potential resistance mechanisms of mutant KRAS inhibitors.

While he was encouraged that a prestigious journal published the research, Tuveson said he hopes this type of observation “will lead to something that will be useful for a pancreatic cancer patient and not just” provide compelling ideas.

Cheng attended medical school for two years before joining Tuveon’s lab for the next six years.

Cheng defended his thesis in 2020 during the pandemic on a zoom call.

“I was one of the first people to defend with this format for both CSHL and SBU,” Cheng explained. “I was able to invite many friends and family that probably would not have been able to make the trip.”

Cheng’s family has battled cancer, which contributed to his research interests.

When he was an undergraduate, he had an uncle develop glioblastoma, while another uncle and his grandfather developed colon cancer.

“I knew I wasn’t going to be able to do much about their medical condition, but I wanted to work on something that people cared about,” Cheng explained.

Outside of the lab, Cheng enjoys working on his car and his motorcycles. He feels a sense of autonomy working on his own projects.

He’s most proud of a motorcycle for which he rebuilt the front end with parts from another model to outfit a larger brake system.

A native of St. Louis, Cheng is a fan of the hockey team, the Blues. He owns a game-worn jersey from almost every member of the 2019 cinderella team that won the Stanley cup, with some of those jerseys coming from Stanley Cup final games.

Cheng plans to apply to residency in internal medicine this year because he wants to continue applying what he learned in his scientific and medical training.

The clinical work reminds him to treat patients and not just the tumors, while scientific research trained him to loo at evidence and literature carefully to find clinical gaps, he explained.

Otto Heinrich Warburg

By Leah S. Dunaief

Leah Dunaief

There are two good stories in “Ravenous: Otto Warburg, the Nazis, and the search for the Cancer-Diet Connection.” The newly released book, by Sam Apple, is about the Nazi’s hunt for the cause of cancer and the remarkable support Hitler gave, before and during World War II, to Otto Warburg, a premier scientist, homosexual and Jew.

Hitler’s mother, possibly the only person he loved, died a painful death from breast cancer. Hitler, reportedly a vegetarian and a hypochondriac, periodically thought he was dying of cancer. Otto Warburg, who won the Nobel Prize in 1931 and had been nominated repeatedly for the prize during his career, did in-depth biochemical research on the metabolism of tumors, especially cancer cells. Despite Warburg’s several obvious drawbacks and outspoken criticism of Nazi values — he refused to have Nazi flags in his lab or offer the Nazi salute — Hitler protected him and allowed him to do his work.

Otto Heinrich Warburg, born in 1883 into a prominent family of bankers and scientists, first distinguished himself in the elite cavalry regiment, the Uhlans, during WWI. He won the Iron Cross for bravery and was still fighting at the front in 1918 when Albert Einstein, a close friend of his physicist father, wrote him a letter urging him to come home. Einstein told him that science needed him. That, combined with his breakthrough research before the war on sea urchins, and his aristocratic family, did much to solidify his lifetime arrogance.

He did return home, continued his distinguished work, and was named director of a Kaiser Wilhelm Institute in Berlin founded by the Rockefeller Foundation, designed by him in the Rococo style, in 1931. He proceeded with his investigations into the causes of cancer, which had been relatively rare until the 19th century but was exploding in numbers in the early 20th century. The German people, along with people in the United States and elsewhere, were terrified of the disease.

Warburg’s hypothesis was that cancer growth was caused by tumor cells generating energy (to reproduce) mainly by the anaerobic (no oxygen) fermentation of glucose. Healthy cells, by contrast, generate energy mainly from oxidative breakdown with the salt pyruvate in the mitochondria (part of the cell responsible for producing the cell’s energy.)  If you don’t understand those last sentences, it doesn’t matter. The point is that Warburg believed the primary cause of cancer was the replacement of the respiration of oxygen in normal body cells with the fermentation of sugar. Therefore the culprit: SUGAR. 

Today the understanding of the cause of cancer is mutations in oncogenes and tumor suppressor genes that lead to a malignant transformation. The metabolic changes in cells that Warburg observed were not causative, today’s scientists believe, but the result of those mutations.

Warburg’s work offered support for the role of metabolism in the mitochondria in aiding tumor suppression. He oversimplified the complex interactions between the mitochondria and the cell nucleus, between metabolism and mutations.

After the war, Warburg did come to the United States, but his self-important personality, his tyrannical behavior in the lab, his imperiousness with his peers and finally his inability to admit error, all helped to push his research out of sight. He ultimately returned to Switzerland.

In the 1960s, scientific attention turned to the newly defined DNA and cancer-causing genes. Only with the new century has there been a metabolism revival and attention to the role of insulin and the link with obesity.

The book offers us interesting history, both about the Nazis and scientific research into the causes of cancer. Reading it will certainly make us think about what we eat.

METRO photo
Mouthwatering barbeque options can decrease health risks

By Daniel Dunaief

Dr. David Dunaief

What better way than the unofficial launch of summer holidays – and summer barbeques – to kick-start you on the path to preventing chronic diseases? In the past, I have written about the dangers of processed meats in terms of causing chronic diseases, such as cancer, diabetes, heart disease and stroke. These are foods commonly found at barbeques and picnic meals. Therefore, I think it is only fair to talk about healthier alternatives and the evidence-based medicine that supports their benefits. The Mediterranean-style diet is a key to success. It is composed of thousands of beneficial nutrients that interact with each other in synergistic ways. 

The Mediterranean-style diet, as I have mentioned previous articles, includes green leafy vegetables, fruit, nuts and seeds, beans and legumes, whole grains and small amounts of fish and olive oil. We all want to be healthier, but these are the summer holidays – doesn’t healthy mean tasteless? Not at all!

At a memorable family barbeque, we had a bevy of choices that were absolutely succulent. These included a three-bean salad, mandarin orange salad with mixed greens and a light raspberry vinaigrette, ratatouille with eggplant and zucchini, salmon fillets baked with mustard and slivered almonds, roasted corn on the cob, roasted vegetable shish kebobs, and large bowl of melons and berries. I am drooling at the memory of this buffet. Let’s look at the scientific evidence that explains why these foods help us.

Cancer prevention

Fruits and vegetables may help prevent pancreatic cancer. This is very important, since by the time there are symptoms, the cancer has spread to other organs and the patient usually has less than 2.7 years to live (1). Five-year survival is only five percent (2). In a case control (epidemiological observational) study, cooked vegetables showed a 43 percent reduction and non-citrus fruits showed an even more impressive 59 percent reduction in risk of pancreatic cancer (3). Interestingly, cooked vegetables, not just raw ones, had a substantial effect.

Garlic plays an important role in reducing the risk of colon cancer. In the IOWA Women’s Health Study, a large prospective (forward-looking) trial involving 41,837 women, there was a 32 percent reduction in risk of colon cancer for the highest intake of garlic compared to the lowest. Vegetable consumption also showed a statistically significant reduction in the disease, as well (4). Many of my patients find that fresh garlic provides a wonderful flavor when cooking vegetables.

Diabetes – treatment and prevention

Fish plays an important role in reducing the risk of diabetes. In a large prospective study that followed Japanese men for five years, those in the highest quartile of intake of fish and seafood had a substantial decrease in risk of type 2 diabetes (5). Smaller fish, such as mackerel and sardines, had a slightly greater effect than large fish and seafood in potentially preventing the disease. Therefore, there is nothing wrong with some grilled fish on the “barbie” to help protect you from developing diabetes. 

Nuts are beneficial in the treatment of diabetes. In a randomized clinical trial (the gold standard of studies), mixed nuts led to a substantial reduction of hemoglobin A1C, a very important biomarker for sugar levels for the previous three months (6). As an added benefit, there was also a significant reduction in LDL, bad cholesterol, which reduced the risk of cardiovascular disease.

The nuts used in the study were raw almonds, pistachios, pecans, peanuts, cashews, hazelnuts, walnuts and macadamias. How easy is it to grab a small handful of unsalted raw nuts, about 2 ounces, on a daily basis to help treat diabetes?

Stroke prevention

Olive oil appears to have a substantial effect in preventing strokes. The Three City study showed that olive oil may have a protective effect against stroke. There was a 41 percent reduction in stroke events in those who used olive oil (7). Study participants, who were followed for a mean of 5.2 years, did not have a history of stroke at the start of the trial.

Though these are promising results, I caution you to use no more than one tablespoon of olive oil per day, since there are 120 calories in a tablespoon. 

It is not difficult to substitute the valuable Mediterranean-style diet for processed meats, or at least add them to the selection. This plant-based diet offers a tremendous number of protective elements in the prevention of many chronic diseases. So this Independence Day and beyond, plan to have on hand some mouth-watering healthy choices.

References:

(1) Nature. 2010;467:1114-1117. (2) Epidemiol Prev Anno 2007;31(Suppl 1). (3) Cancer Causes Control. 2010;21:493-500. (4) Am J Epidemiol. 1994 Jan 1;139(1):1-15. (5) Am J Clin Nutr. 2011 Sep;94(3):884-891. (6) Diabetes Care. 2011 Aug;34(8):1706-11. (7) Neurology. 2011 Aug 2;77(5):418-25.

Dr. David Dunaief is a speaker, author and local lifestyle medicine physician focusing on the integration of medicine, nutrition, fitness and stress management. For further information, visit www.medicalcompassmd.com. 

Dr. Paolo Boffetta

By Daniel Dunaief

Dr. Paolo Boffetta, who joined Stony Brook University as Associate Director for Population Sciences in the Cancer Center in the midst of the pandemic last April, asks the kinds of questions doctors, scientists and non-scientists also raise when they look at illnesses among groups of people.

An epidemiologist who worked for 20 years at the World Health Organization and at Mt. Sinai Hospital in New York City for 10 years, Boffetta joined Stony Brook because he saw an opportunity to replicate the kind of success he and others had at Mt. Sinai, where he helped the institution earn a National Cancer Institute designation. Cancer centers can apply for NCI designation when they have a well-established portfolio of research.

Dr. Paolo Boffetta

“The idea to try to get the Cancer Center” at Stony Brook “to the NCI level was very appealing,” Boffetta said. Stony Brook was looking to build out its population sciences work.

In addition to the big picture goal of helping Cancer Center Director Yusuf Hannun and other researchers earn that designation, Boffetta has partnered with several scientists at Stony Brook and elsewhere to address questions related to various illnesses.

Boffetta has applied for $12 million in funds over six years from the National Cancer Institute for a new water project.

The research will recruit people who are over 50 years old across several towns, primarily in Suffolk County to explore the link between the potential exposure these residents had to different chemicals in drinking water and types of cancers.

“The main idea is that people may be exposed to carcinogens through drinking water according to where they have been living,” Boffetta said.

The scientists will follow these residents over time to determine the health impact of their town of residency. “If this is funded, this will be a major project that will involve many institutions,” he added.

The chemicals they will study include nitrates, chlorinated solvents, 1,4-dioxane, and perfluoroalkyl substances.

While he awaits word on potential funding for the water effort, Boffetta and others are looking at another project to explore the link between various environmental factors and bladder cancer. This is not limited to drinking water contamination. The group plans to analyze tumor samples to see whether they can detect fingerprint mutations.

World Trade Center Studies

Boffetta also plans to continue and expand on work he’s done at Mt. Sinai with responders of the World Trade Center attacks, a group that has received considerable attention from numerous scientists at Stony Brook.

He has been “doing a number of quite detailed analyses on cancer, including survival of workers and responders to developing cancer,” he said. The WTC survivors are enrolled in a medical monitoring treatment program, sponsored by the Centers for Disease Control, which means they “should be getting good cancer care.”

Boffetta has been comparing their survival to the population at large in New York, analyzing how the risk of cancer evolved over the almost 20 years since the attacks.

Boffetta has started to look at one particular new project, in which he studies the prevalence of clonal hematopoiesis of indeterminate potential (or CHIP), which is an asymptomatic condition that increases the likelihood of leukemia and cardiovascular disease. He is studying 350 healthy World Trade Center responders and a group of historical controls from the literature.

He plans to use the results of his study to develop strategies to prevent these diseases in WTC responders.

In some of his WTC studies, Boffetta is working with Ben Luft, Director of the Stony Brook WTC Wellness Program at the Renaissance School of Medicine at SBU, who has been involved in providing extensive research and clinical support for WTC responders.

Boffetta is an “internationally renowned cancer epidemiologist” who contributed his “vast experience on the impact of environmental and occupational exposures [that were] seminal in our understanding of how the disaster of 9/11 would eventually lead to increased numbers of cancer cases among responders,” Luft wrote in an email.

Boffetta’s contribution and understanding will “transcend the events of 9/11 and its impact on the responder community to a general understanding of the increased incidence of cancer on Long Island,” said Luft.

While Boffetta has several academic affiliations with institutions including Harvard University, where he teaches a class for a week each year, and Vanderbilt University, his primary focus involves the work he conducts at Stony Brook and at the University of Bologna.

Boffetta plans to keep his research team considerably smaller than the 80 to 100 people who worked with him at the World Health Organization. Indeed, he said he mainly focuses on working with collaborators. He plans to hire his first post doctoral researchers soon.

As for teaching, Boffetta has been working with the program directors of the Masters of Public Health to develop a tract in epidemiology. He plans to start teaching next year.

Boffetta, who spoke with Times Beacon Record News Media through WhatsApp from Italy, said he often works double shifts to remain in contact with his colleagues in the United States and Europe. When he’s in the United States, meetings can start at 6 in the morning to connect with his European counterparts in the middle of their day. When he’s in Italy, his last meetings sometimes end at 11 p.m. or midnight.

Boffetta, however, said he has “a normal life,” which, prior to the pandemic, included trips to the opera and museums. He also enjoys skiing and hiking.

Married to Antonella Greco, who used to teach Italian, Boffetta lives in New York City. He has three daughters, who live in Brooklyn, Italy and Uruguay. He has been vaccinated against COVID-19 and is looking forward to the opportunity to interact with his colleagues in person once restrictions caused by the pandemic ease.

Photo by Barbara Anne Kirshner

By Barbara Anne Kirshner

Hair … It is our crown.

We spend billions of dollars coiffing it. 

We have it shaped, colored, highlighted, blown out, straightened, curled, and conditioned.

But what happens when our crowning jewel is threatened?

Too many hear a doctor sympathetically announce, “I’m sorry, but you have cancer.”

After that frightening diagnosis is flung into the air, what is the treatment? Many are forced to undergo the next Big-C Word-Chemotherapy.

Chemo’s harsh attack is the common choice for killing cancer and keeping it from spreading, but in so doing, it ravages the body and those once-prized locks fall out in clumps.

This shocking side effect of chemo compounds the tragedy of the cancer diagnosis.

What recourse does one have when that cherished mane disappears? Some resort to simple scarves wrapped around the now bare head or big picture hats, but there is another solution; a solution that will build the morale as it resurrects that once bounteous coif. 

That’s where technicians, like my sister Judy, come into play. She works in hair replacement. Many of the people she sees each day are facing the greatest battle of their lives against the Big-C. These people are starved for a sense of normalcy. They long to look in a mirror and see their former selves before cancer took control of their lives. These valiant warriors reject disappearing until treatment is over. This is a motivating factor in seeking out someone like my sister.

I never thought about my sister’s profession. I knew what she did and figured that we both chose people-oriented careers (I am a teacher). But I never really considered what my sister did for the morale of people until I saw how she helped a dear friend of mine who was diagnosed with cancer.

The treatment for my friend was aggressive chemo. She was admitted to the hospital for a week each month and hooked up to constant chemo. This left her depleted of all energy and feeling terribly nauseous. Her hair that she had always been meticulous about started falling out. 

Prior to cancer, she had it regularly colored with highlights added. She wore it straight, shoulder-length and for summers added a Brazilian treatment. She lamented the effects of chemo, particularly the loss of her hair. She told me that she might get a wig, because she wanted to return to work. That’s when I suggested she see my sister.

With hope in her heart, she made an appointment at the hair replacement shop where my sister works, The Riviera in Syosset. She was greeted by Jack, the owner of the shop. His understanding immediately comforted her. He asked her for a photo so he had some idea of her preferred hairstyle.

When the wig was delivered, my sister went to work on her. The moment my sister replaced the bald head with luscious tresses the emotion set in. My friend dissolved in tears of joy, the first happiness that she had experienced since that dire diagnosis. She was immediately impressed by my sister’s gentle nature and care.

My friend’s confidence returned with the return of her hair. She went back to work with her upbeat nature intact.

Her emotional transformation made me realize the very special and delicate work my sister does every day with people like my friend who long for life before cancer. My sister rebuilds self-esteem; such a priceless gift.

I am thrilled to report that my friend is now cancer free and her natural hair has grown back. She has developed a bond with my sister, thankful for the return of her confidence that came at such a crucial time.

This close-up look has given me a better insight and appreciation for what Judy does every day for countless cancer patients and I’m bursting with pride that she is my sister.

Miller Place resident Barbara Anne Kirshner is a freelance journalist, playwright and author of “Madison Weatherbee —The Different Dachshund.”

Cindy Court (left) from Mather and Susanne Igneri (right) from Lustgarten accepted the donations from Yacht Club members Gary Passavia, Chuck Chiaramonte and Karl Janhsen. Photo from Mather Hospital

The Port Jefferson Yacht Club, just by the nature of their craft, know how to navigate turbulent times.

It’s why even despite the pandemic and setbacks to its 11th annual Village Cup Regatta, the group still managed to raise $40,000 which is split between Mather Hospital and the Lustgarten Foundation, which funds pancreatic cancer research.

Normally held in September, the regatta is a competition between teams for the Village of Port Jefferson and Mather Hospital. Whichever team wins gains the coveted trophy and bragging rights for the year, but the real purpose is to generate funds for pancreatic cancer research and cancer treatment. Last year the function raised $91,000 

Chuck Chiaramonte, a past commodore for the yacht club who helps head the annual regatta, said they were pleasantly surprised to see just how many people still donated even in a time where many are experiencing financial hardship.

While the event is two-fold, one being the club’s outreach to the community to share their love of sailing and the other being its fundraising efforts, only one of those could be focused on this year because of the pandemic, Chiaramonte said.

“When COVID hit, there was no way we could ask club members to have a lot of people crammed into the cockpit of their boats, and so we thought we would have to cancel,” Chiaramonte said. “But then later on we were thinking, pancreatic cancer is as bad as ever, we thought we could still hold the charitable portion.”

The regatta still happened this year, but in a smaller capacity. Instead of boats crowded with people, each sailing craft was only allowed a max of two persons. Normally the event has Mather racing against the village, just using club members’ boats. Calling it the Village Cup “COVID Race” this year, club members still raced carrying banners of sponsors and others who donated to the event, though the village/hospital competition was dropped.

Though it may have raised less than previous years, and even in the midst of so much tragedy due to the pandemic, cancer and specifically pancreatic cancer still weighs heavy on so many club members’ minds, with so many friends and family having been lost to the disease. And this year, with COVID-19, club members knew they had to do as much as they could to help the hospital that went through hell during the pandemic’s height. 

Kenneth Roberts, the president of Mather Hospital, thanked the yacht club for its support.

“We are grateful to the Port Jefferson Yacht Club and their continuing commitment to Mather Hospital, even in the face of the COVID-19 pandemic,” Roberts said in a statement. “This is a wonderful example of how we will get through this, together.”  

Chiaramonte said the yacht club plans to return for the 12th annual regatta in 2021, this time, hopefully, back to its normal self.

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Kim Bardes, right, and her husband Bruce just before she started her first round of chemotherapy July 28. Both she and her husband have recently been diagnosed with two different types of cancer. Photo from Bruce Bardes’ Facebook

By Odeya Rosenband

Kim and Bruce Bardes, husband and wife, of Shoreham are in need of support, as one after the other have now been diagnosed with cancer. A friend of the family has started a GoFundMe campaign that has raised $24,100 of its $50,000 goal, as of July 28.

“Back in April, Bruce noticed that one of his legs was swollen,” Kim said. “But he didn’t want to go to the hospital because of COVID-19.” 

Kim Bardes, right, and her husband Bruce have recently been diagnosed with two different types of cancer. Photo from Bardes’ GoFundMe

After eventually visiting the emergency room when the swelling worsened, Bruce was told he had a blood clot in one of his legs but was quickly discharged due to coronavirus guidelines. On May 6, after gardening in the backyard — one of his favorite activities, according to his wife — Bruce suffered a heart attack and stroke in the family home. When he was found unresponsive, his son ran to the neighbor’s house who was trained in CPR. Doctors suspected Bruce had cancer, and a week later, May 21, Bruce was diagnosed with stage IV metastatic lung cancer. 

Nearly two months after Bruce’s diagnosis, the family received more devastating news. Kim was diagnosed with aggressive inflammatory breast cancer. 

“It was seven weeks of me just getting my mindset around the fact that this was happening, trying to be his supporter and his support system, taking care of all of his medical needs — doing what any wife would do — when I had noticed one day that my left breast felt different in one area.” 

With a “funky family history,” Kim had gotten routine mammograms since she was 30 years old. When she visited her doctor June 30, she received a diagnosis for a type of breast cancer she had never even heard of. 

Bruce began his chemotherapy treatments in May, and Kim started hers July 28.

“I know our condition is going to get even worse because now I’m not just going to be tired from running my husband around and taking care of home, now, I got to add myself to this scenario somehow. And I don’t know how I’m going to feel from the treatments,” she said.

With a crackling voice, Kim describes their “love story turned tragedy,” as she calls it. They met at 15 years old, as sophomores at Half Hollow Hills East in Dix Hills. The basketball player and cheerleader were locker neighbors and a year later — thanks to Bruce’s persistence — they were a couple. They started dating when they were 16 years old, 34 years ago. High school sweethearts, Bruce and Kim got married in 1995 and had their first son, Austin, in 1996 and their second, Tanner, in 1999. 

“We met 35 years ago and never had a fight,” Bruce jokingly adds from the next room. “If we can’t joke, then we cry. And we’ve already done too much crying.” 

“Anybody would describe my husband as the kindest person they have ever met,” Kim said. According to their GoFundMe, Bruce coached youth basketball and baseball teams in Long Island for many years. Although he has been on disability leave since 2013 due to back injuries, he continues to be remembered as a beloved coach and has a “huge baseball family that has been giving them a lot of support,” Kim added. Kim, whose eBay business was already struggling due to the pandemic, had to halt her sales in order to care full time for her husband. 

“I don’t have a job where I can take sick leave,” Kim expressed. Now, the family has no source of income. 

“We were so excited for this year — we were turning 50, celebrating our 25th wedding anniversary, and were looking forward to the second half of our lives,” she said. “Our kids are now grown up and we were getting back to being us again … we even talked about moving to Florida.” 

Kim added, “I feel blessed that we have never been hit this hard, but I didn’t expect that when we would be hit, it would be this hard.”

Overall, Bruce has been feeling better following his chemotherapy treatments. 

“He hasn’t lost a stitch of hair, which I’m definitely going to be jealous of,” Kim joked. The hardest part is going through their doctors’ visits alone, due to coronavirus guidelines. 

“COVID is making it 10 times harder because we can’t have any normalcy even if we try to,” she said. “It’s a weird feeling to ask for help because that’s not who I am, ever. But I’ve had to put my pride aside a little bit …. I can’t do it all.”

Kim, whose extended family describes her as the “matriarch,” had adopted the role of hosting Thanksgivings and annual Fourth of July celebrations. Now, without the time or energy, she’s struggling to adapt to her new normal that doesn’t include her regular hobbies like cooking and hosting. 

“This isn’t the life we had, not even close to it,” Kim said. “It seems like somebody else’s life.” 

Kim and Bruce’s family, friends and Shoreham community have been great supporters — in addition to the GoFundMe — offering their services, giving gift cards to local restaurants and writing letters. 

“Our younger son is now a shadow and doesn’t leave us alone,” Kim said. 

Their older son moved back home from Brooklyn in order to help. Kim’s mom and dad, who are 75 and 78, respectively, live in an apartment attached to the Bardes’ house and have also been significant supporters. Kim is one of three children who have all had cancer. Her sister is a nurse and has been instrumental in assisting the family, especially with their medical needs. Kim’s brother passed away at 33 years old from lymphoma. 

“You do the best you can for people and try to do the right thing and it doesn’t matter who you are but sometimes life just attacks you. It feels like we are under attack … and I don’t know why,” she said.

A statement on their GoFundMe reads: “As you may know, medical expenses and life expenses add up quickly and the family needs to make financial decisions based on the best prognosis and not the cost of care … If you are able to support the family during this time please donate. But if not, that’s okay, please join them in prayer.” 

The GoFundMe is available at:  https://www.gofundme.com/f/nqp2qt-help-bruce039s-fight-against-cancer.

Stock photo

By Leah S. Dunaief

Leah Dunaief

If presented with a decision you do not wish to make, especially if told you have no choice, don’t do it. Don’t accept the unacceptable because you are told there is no other way to go. There is (almost) always another way. I will share with you a true story that recently happened to make my point. It may seem like the telling of a miracle.

A man I know, who lives many hundreds of miles away, was having abdominal pain and his abdomen was somewhat distended, so he made an appointment and went to see his primary care physician. The doctor palpated his distressed area, front and back, and sent him for imaging tests. Of particular concern was the fact that the patient had come into this world with only one kidney. When the results came back, the prognosis wasn’t good. He was sent by his doctor to an oncologist.

At this next appointment the grim news was confirmed. He had a cancerous tumor on the kidney, and the organ would have to be removed. That meant he was fated to be on dialysis the rest of his life. The oncologist then sent the patient along to an oncology team that specialized in cancerous kidney surgery in a big city hospital. The appointment was for four days later, and while he waited, the man did extensive research on the internet, learning everything he could about cancer of the kidney. At that next visit, the diagnosis was repeated and the team urged what they believed to be the inevitable: arrange to have the stricken kidney removed.

Three doctor appointments, and at all three, there was agreement as to the diagnosis and treatment. Realizing that he was about to have his life altered, and determined to make one more try at changing the outcome, he returned to the internet. One physician in particular, the renal department chairman of a research hospital, had been impressively profiled. The hospital was in a different part of the country, and COVID-19 was beginning to close down most airline flights. With little expectation of actually being seen by this specialist, and while he was worried about how he might get there and return, he nonetheless picked up the phone and called the department. He was given an appointment almost immediately. He almost didn’t accept it when he was told that he couldn’t bring his test results with him, that those tests would have to be done all over again. But in the end, he went.

It took three flights before he reached his destination, and together with his family, he checked into the hotel opposite the hospital, as he had been instructed to do.

For the next two days, there were extensive tests, and then the chairman told him the conclusion: the chances were 95 percent that they could save his kidney. He wheeled around and hugged the doctor.

Three days after the surgery, which involved a technique called modelling accompanied by 3500 pictures of the diseased kidney, he walked out of the hospital, holding his family tightly around him. The doctors told him the wondrous news. He was cancer free. The tumor had not yet begun to spread. 

He had found the right person to deal with his problem because he refused to accept the original path laid out before him, even though he had been told there was no choice. He was determined to find another way, creative in his casting about for an alternative and tenacious enough to transcend the obstacles on his way to a successful outcome.

I have known this story for more than a month, thrilled by its outcome yet not wanting to invade the privacy of the principals. So I have not identified any of the people or institutions involved. But I believe it is an experience that must be told to be of possible help for others. And the choices one is presented with don’t have to be life threatening. They can just be part of daily life. The moral is still the same.

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Dawn Blatt is to be one of 14 people to be the face of a national campaign for colorectal cancer awareness. Photo from Fight CRC

By Julianne Mosher

A local Miller Place woman is spreading the word that colonoscopies can help save a life during National Colorectal Cancer Awareness Month this March.

Dawn Blatt is to be one of 14 people to be the face of a national campaign for colorectal cancer awareness. Photo from Fight CRC

When Dawn Platt was diagnosed with stage III colon cancer in 2016, she knew she wanted to use this experience to help others. 

“Four days after my first colonoscopy, I heard those three words, ‘you have cancer,’ and it changed everything,” she said. 

Then just 51 years old, the Miller Place resident went through surgeries and chemotherapy to fight it. Now, four years later, she’s in survivorship mode and doing a lot better. “There’s no evidence of disease,” Blatt said. And now her goal is to get the word out. 

“I knew that I had to make this into something positive that can be an impact to other people,” she added.

Last year, Blatt became an ambassador for Fight Colorectal Cancer, the nation’s leading colorectal cancer advocacy organization. One of 14, she will be featured in a national campaign to promote awareness of colorectal (colon and rectal) cancer, which is the second leading cancer killer in the U.S. for men
and women. 

“Each year Fight CRC selects a group of ambassadors from across the country to represent our community year-round,” said Anjee Davis, president of Fight CRC, in a statement. “They bravely rally to raise awareness for this disease. … We hope their stories resonate with people and provoke the over 30 million people aged 45 years and older who have not been screened to get screened.”

Officially launching in Times Square  Feb. 26, the public service announcement will appear during the NASDAQ Opening Bell Ceremony at 9 a.m. Her story will also be featured on Fight CRC’s social media pages starting in March. She will join the organization by heading down to the Capitol for a call on Congress to discuss issues and advocate funding for cancer research.

“Colon cancer can be preventable,” Blatt said. “I want to help people and if I can talk to legislators about it, then I’m going to.”

Sixty percent of colorectal cancer deaths could be prevented with screening, especially if someone knows that it runs in their family. “After joining Fight CRC, I have seen and heard a lot,” Blatt said. “It’s important to get yourself checked out in your 50s, but even now for people in their 20s and 30s.”

She’s hoping that her advocacy will save someone’s life. “Colonoscopies may not be the most pleasant thing, but it’s better than surgery and chemo,” she said. “Go get checked out. … Knowledge is power.”

Blatt added that Friday, March 6, is Wear Blue Day to raise awareness and fight CRC. 

Northport power plant. File photo

When the Town of Huntington’s planning board originally authorized in 1965 a site plan for the Northport power plant’s first generating unit on the shores of the Long Island Sound, the impact on the greater safety, health and general welfare of the community was an overarching concern. In fact, the town’s approval stipulated that plant operators were required to submit emissions reports to the town, which were subject to regular review by town officials. 

Today, the plant has expanded to four units, and while the town is still searching for records, officials do not know the last time the plant submitted an emission report from on-site monitors for a review. Town attorney Nick Ciappetta said the town is reviewing whether or not it has monitoring authority. The EPA and DEC, he said, have jurisdiction over plant emissions. 

Some lawmakers firmly disagree, and State Sen. Jim Gaughran (D-Northport) is calling for action. 

“The town has had more power than it’s realized,” he said. “It should take whatever action it needs to take.”  

Gaughran said he regularly drives past the plant and smells foul odors. Last year, he requested a state health investigation after learning that graduates of Northport High School Class of 2016 were diagnosed with leukemia and lymphoma, after community members said they want to know if the plant’s emissions are a factor. 

State health department investigators have now expanded their study to look at cancer rates in a broader population to look for patterns. (See story on Page A3) With that investigation underway, Gaughran finds it prudent to take steps to better protect the community. 

Town Council member Joan Cergol agrees. 

“If the Town, in its rezone of the property, or any of its agencies or boards in the 1960s imposed conditions on LILCO to protect the health and safety of Huntington residents, then it stands to reason that its successors should be bound by the same,” she said.

It is unclear what action if in any will be taken, but some are saying additional precautions would be prudent. 

Danielle DeSimone is one several young adults diagnosed with leukemia from the Northport High School Class of 2016, who received a bone marrow transplant and is now in remission. She said she would absolutely support any policies that would better protect the public’s health. 

“May no more families be faced with this burden unnecessarily,” she said in an email. 

As the state’s health investigation continues, and as the town bears the additional burden of fighting LIPA and National Grid, spending $4.2 million to date, many people are looking at the plant with a discerning eye. 

According to the DEC, the Northport Power Plant emissions are in severe violation of state and federal the air pollution standards for nitrous oxide and VOCs, which contribute to ozone. When inhaled, ozone chemicals react chemically with many biological molecules in the respiratory tract, the EPA reports, leading to adverse health effects.

It’s difficult to know whether or not a specific environmental toxin will cause a particular individual to develop cancer or other diseases, according to a 2003 report “Cancer and the Environment” published by the U.S. Department of Health and Human Services. 

But significant sources of VOCs are chemical plants, gasoline pumps, oil-based paints, autobody shops, and print shops. Nitrogen oxides result primarily from high temperature combustion. Significant sources are power plants, industrial furnaces and boilers, and motor vehicles, according to the state Department of Environmental Conservation Permit Review Report from February 2019.

In response to inquiries,  National Grid spokesperson Wendy Ladd said, “we submit our emissions report to the EPA and NY DEC.”

The DEC states that ozone is a regional air pollutant and most human and economic activity in the NYC metro area contribute in some way to ozone exceedences. 

“If the DEC finds any facility poses an imminent threat to public health or the environment, the agency works to address the situation immediately,” said DEC spokesman Kevin Frazier.  

Correction: An earlier version of this story reported that the Town Attorney Nicholas Ciappetta said that the town had no authority over emissions monitoring.  The town is actually still reviewing the matter. (updated 1/29/2020)