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Bacteria

Doctors warn against swimming in brackish water and advise wearing protective gear when handling raw shellfish, among other safety measures to guard against vibrio vulnificus. Photo from CDC

In mid-August, Suffolk County recorded its first death in seven years from vibrio vulnificus, often referred to as “flesh-eating bacteria.”

A man over the age of 55 who had underlying health conditions was admitted to a local hospital with a leg wound and chest pain in July. He died the following month due to a bacterial infection.

Dr. Susan Donelan, medical director of health care epidemiology at Stony Brook Medicine. Photo from Stony Brook Medicine/Jeanne Neville

“People that are at risk should be more aware” of an infection they can get from raw shellfish or brackish water, said Dr. Susan Donelan, medical director of health care epidemiology at Stony Brook Medicine. That includes people who have liver disease, poorly controlled diabetes, are considered immune suppressed because of a condition or are taking medication that can cause immune suppression.

At the same time, Connecticut reported that three people died from contracting the potentially deadly bacteria. Two of them died from wound infections, the third contracting the bacteria from handling raw oysters.

To be sure, most people are not vulnerable to contracting the disease or from its effects.

“The general public is not at an increased risk,” said Donelan. “In most cases, [infections] are mild or moderate.”

Those who might be vulnerable to vibrio can avoid it by not handling or eating raw or undercooked shellfish, staying away from shellfish juices, covering up wounds or not swimming in brackish waters.

People can shuck shellfish with gloves to minimize any injuries to their hands and can wash their hands before and after coming in contact with raw shellfish.

“Some people like putting raw oyster juice into different drinks,” Donelan said. “You want to avoid doing that.”

Area doctors and health officials urged people with wounds — which could include cuts, new body piercings or tattoos — to avoid swimming in brackish or salt water.

“The bacteria thrives in brackish water, where fresh water meets ocean water,” Dr. Gregson Pigott, Suffolk County health commissioner, said in an email. “It would be best to avoid those waters if you have an open wound or a chronic health condition.”

Donelan also suggested that people who go in the water with such wounds cover them up with a waterproof bandage.

Symptoms

People who contract vibrio typically develop a host of symptoms.

These can include “diarrhea, abdominal cramps, nausea and vomiting,” Pigott explained.

Dr. Gregson Pigott, commissioner of the Suffolk County Department of Health Services. File photo

Symptoms from consuming raw shellfish can start within 24 hours of a meal. A person exposed  through their skin can develop a blistering skin or soft tissue infection.

Pigott urged residents to seek help for gastrointestinal symptoms or a worsening skin infection.

Those who are unable to drink enough fluids to counterbalance the losses through the gastrointestinal tract could become dehydrated, doctors warned.

Lightheadedness and hypotensive appearances can be a warning sign that residents should seek medical help.

Wounds may become red, hot and tender with streaky marks leading away from them. These are “all concerning things” that might signal an infection, Donelan said.

People generally know how quickly cuts heal. A cut that gets visibly worse quickly, which could include blistering of the skin with a bolus that looks like murky fluid or blood beneath it should be “very concerning signs,” Donelan added.

Knowing that the bacteria is present in Long Island Sound and being aware of it could help people prevent exposure or react early to an infection.

This summer, area hospitals have not reported an unusual number of infections, according to Donelan.

Doctors said the bacteria typically lives in waters between 50 and 80 degrees Fahrenheit, which means that the longer the waters remain warm amid a hot summer and warming climate, the more likely the bacteria will be prevalent in waters around the Island.

Illness and travel

At this time of year, residents return from their seasonal travels. They sometimes bring unwanted microorganisms such as viruses or bacteria with them.

Health care professionals urged residents to notify their doctors about their travels prior to getting sick, so doctors can get an idea of where and how they might have contracted an illness.

When people return from cruises, plane trips or other travel, they should “help the emergency departments become aware of where they’ve been,” Donelan said.

Local shellfish, like oysters and clams, are harvested on the North Shore. File photo

Citing recent bacteriological surveys, the New York State Department of Environmental Conservation announced emergency regulations to change the designation of underwater shellfish lands in Suffolk county. Shellfish harvesting will be closed or limited to particular months in approximately 1,844 acres of bays and harbors in Brookhaven, Huntington, Islip, Smithtown, Riverhead, Southampton, Southold, East Hampton and Oyster Bay, to comply with state and national standards to protect public health.

Through the National Shellfish Sanitation Program, states are required to conduct routine water quality sampling in shellfish harvesting areas. Failure by a state to comply with these national water quality-monitoring protocols could lead to a prohibition of the sale of shellfish products in interstate commerce.

The DEC’s analyses of water quality in these areas showed increased levels of fecal coliform bacteria. The increased bacteria indicates that shellfish harvested from these areas have the potential to cause human illness if consumed.

Bacteria can enter the waters from a variety of human, animal, cesspool and storm water sources. The DEC is working with local governments in Suffolk County on major projects to improve water quality in the region, an effort that will reduce discharges of bacteria and nitrogen. The DEC will work with partners to track down the bacteria sources and oversee mandated local efforts to address illicit discharges of sewage into storm sewer systems, while also continuing to evaluate sources of bacteria in an effort to resolve the issue.

The DEC’s emergency regulations will change the designation of the affected shellfish areas to “uncertified,” or closed, for the harvest of clams, mussels, oysters and scallops, either year-round or seasonally.

In Mount Sinai Harbor in Brookhaven Town, approximately 200 acres will be reclassified as closed for the harvest of shellfish during the period May 1 to Oct. 31.

In Stony Brook Harbor, approximately 300 acres shall be reclassified as closed from May 15 through Oct. 31, to closed instead from May 1 through Dec. 31, for the harvest of shellfish.

In Cold Spring Harbor, approximately 99 acres shall be designated as closed during from May 1 through Oct. 15, for the harvest of shellfish.

For more information about shellfish safety and New York’s role in the National Shellfish Sanitation Program, visit the DEC’s website. The emergency regulations adopting the changes are effective immediately. Additional information may also be obtained by contacting the DEC’s Shellfisheries office at (631) 444-0492.

Young bathers dive into the waters of a newly reopened beach at the Centerport Yacht Club. Photo by Rohma Abbas

The county health department warned locals on Friday against bathing at 25 Huntington area beaches, the morning after heavy rainfall drenched the North Shore.

According to the Suffolk County Department of Health Services, it issued the advisory because the rain could have led to bacteria levels in the water that exceed state standards.

“The beaches covered by the advisory are located in areas that are heavily influenced by stormwater runoff from the surrounding watersheds and/or adjacent tributaries,” the department said in a press release, “and, because of their location in an enclosed embayment, experience limited tidal flushing.”

Affected beaches include Eagle Dock Community Beach, Cold Spring Harbor Beach Club beach, West Neck Beach, Lloyd Neck Bath Club beach, Lloyd Harbor Village Park beach, Gold Star Battalion Park beach, Head of the Bay Club beach, Nathan Hale Beach Club beach, Baycrest Association beach, Bay Hills Beach Association beach, Crescent Beach, Knollwood Beach Association beach, Fleets Cove Beach, Centerport Beach, Huntington Beach Community Association beach, Centerport Yacht Club beach, Steers Beach, Asharoken Beach, Hobart Beach (both the Long Island Sound and cove sides), Crab Meadow Beach, Wincoma Association beach, Valley Grove Beach, Prices Bend Beach and Callahans Beach.

The advisory was scheduled to be lifted at 9 p.m. on Friday, to give enough time for two tidal cycles to clear out the water. However, the health department said the advisory would not be lifted if water samples from the affected beaches showed continued high levels of bacteria.

For up-to-date information on the affected beaches, call the health department’s bathing beach hotline at 631-852-5822 or visit the beach monitoring webpage.

Photo from the health department

Blue-green algae has made some waters in Suffolk County unsafe for residents, according to the county health department.

The New York State Department of Environmental Conservation reported recently that in seven nearby bodies of water, levels of cyanobacteria, also known as blue-green algae, have exceeded health criteria, according to the Suffolk County Department of Health Services.

While cyanobacteria appear naturally in lakes and streams in low levels, the department said, they can become abundant and form blooms that are green, blue-green, yellow, brown or red in color. The algae can appear in “floating scums on the surface of the water, or may cause the water to take on [a] paint-like appearance.” Contact with those scummy or discolored waters should be avoided.

Currently affected waters include parts of Lake Ronkonkoma; Old Town Pond, Agawam Lake and Mill Pond in Southampton; Maratooka Lake in Mattituck; Kellis Pond in Bridgehampton; and Wainscott Pond in Wainscott.

Lake Ronkonkoma Beach has already been closed to bathing for more than a week, a health department official said on Monday, because test results showed high levels of a different bacteria — E. coli, caused by fowl droppings.

The levels of cyanobacteria and “associated toxins” are particularly high at Agawam Lake, the health department said in a recent press release, so residents should avoid direct exposure to water there.

At all of the affected locations, the health department said, residents should not use the water, and should not swim or wade in it. Officials also advised residents to keep both children and pets away from the areas.

If people or pets come in contact with the affected water, health officials said, they should be rinsed off immediately with clean water. If the affected person experiences symptoms such as nausea, vomiting, diarrhea, allergic reactions, breathing difficulties or irritation in the skin, eyes or throat, he should seek medical attention.

More information about cyanobacteria is available on the county health department’s website.

To report a cyanobacteria bloom at a county beach where bathing is permitted, call the Suffolk County Department of Health Services’ Office of Ecology at 631-852-5760. To report one at a body of water in Suffolk County without a bathing beach, call the Division of Water at the New York State Department of Environmental Conservation at 518-402-8179.

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From left, Isaac Carrico with Cannon, 5, and Elizabeth Boon with Sheridan, 16 months, at a beach in North Carolina. Photo by Jim Hinckley

When bacteria become resistant to antibiotics, they enter a category that spurs scientists and doctors to search for alternative remedies.

Bacteria can live singly, in what’s called the planktonic state, in groups or colonies, in which case they form a biofilm, or in numerous possibilities in between. In the biofilm state, they become more resistant to antibiotics, which increases the urgency to find a way to break up the bacterial party.

Elizabeth Boon, an associate professor of chemistry at Stony Brook University, has worked with a gas that, in some species of bacteria, appears to affect biofilm formation. While the details vary from one species to another, scientists have found that low concentrations of nitric oxide most often cause bacteria to leave biofilms.

Boon has discovered nitric oxide-sensing proteins in several strains of bacteria, which might help shed light on how this gas acts as a trigger for bacteria.

Boon’s discoveries are “innovative because they provide a previously important missing link between how bacteria behave in the human body and how the human system fails to counteract bacterial infection and the inflammation it causes,” explained Nicole Sampson, professor and chair in the Department of Chemistry.

Sampson, who called Boon a “rising star in chemical biology,” said her colleague’s work is “providing a much needed molecular explanation for the communication that occurs between bacteria and animals.”

Biofilms have implications for human health, Boon said. While they can be positive, generally speaking, she suggested, they are negative.

“A lot of diseases are caused by biofilms,” while biofilms may play a role with others as well, Boon said. “Open wounds that won’t heal are thought to be the result of biofilm injections around the wound, while people with cystic fibrosis get infections around their lungs.”

Biofilms also may play a part in hospital-borne infections. In a biofilm, bacteria are up to 1,000 times more resistant to antibiotics, Boon said. The exact concentration at which the bacteria switches between a signal from the gas to a group defense varies from one species of bacteria to another.

Similar to hemoglobin, which binds to oxygen in red blood cells and carries it around the body, this protein attaches to nitric oxide. The sensor protein usually causes a change that alters the concentration of cyclic di-GMP, a common bacterial-signaling molecule.

“The iron-containing protein we discovered has a sensitivity to nitric oxide” in low concentration, she said. In terms of a possible treatment of conditions that might improve with a reduction in biofilms, Boon explained that simply blocking the receptor for nitric oxide would cause considerably more harm than good because “anything we could think of to bind would interfere with our own nitric oxide or oxygen-binding protein,” she said.

Still, after the gas binds to the bacteria, there are reactions later on that are exclusive to bacteria.

Boon has also discovered a second protein that binds to nitric oxide, which is called NosP, for nitric oxide-sending protein. This protein has a different architecture from the original HNOx protein and may help explain how those same bacteria without HNOx still respond to the same gas.

Boon recognizes the potential opportunity to use any information for biofilm infections.

Boon, who is working with scientists at Stony Brook, Columbia and at Justus-Leibig-Universität Giessen in Germany, is proposing to work with computational biologists to screen the library of virtual molecules against bacterial proteins.

Boon was nearing the end of her Ph.D. research when she started working with proteins. She did her postdoctoral research in a lab that was characterizing iron proteins. The lab was studying nitric oxide in mammals.

Boon’s lab is down the hall from her husband’s, Isaac Carrico, who is in the same department. The chemists met in graduate school at the California Institute of Technology. The couple lives in Stony Brook with their 5-year-old son, Cannon, and their 16-month-old daughter, Sheridan.

As for her work, Boon is eager to continue to find answers to so many unanswered questions.

“We’re constantly learning, which is subtly shifting the direction of our research,” she said. “That will continue for a long time [because] there’s a whole lot we don’t understand.”