Stony Brook University

From left, Emmy award-winning actor Brian Cox with Alan Inkles, founder and director of the Stony Brook Film Festival at the U.S. Premiere of ‘The Etruscan Smile’ on July 21. Photo by Nick A. Koridis

The 23rd annual Stony Brook Film Festival wrapped up with a Closing Night Awards Reception on July 28. The evening recognized the outstanding new independent films screened at the festival, which was held at the Staller Center for the Arts at Stony Brook University from July 19 to 28.

“The Etruscan Smile,” featuring acclaimed actor Brian Cox in the lead role, won the Grand Prize. The sold-out U.S. Premiere was screened on July 21 with Brian Cox, Thora Birch and Sandra Santiago attending and hosting a Q&A. 

Alan Inkles, founder and director of the Stony Brook Film Festival announced additional awards at the reception. “We received so many enthusiastic responses from our astute audience members over the ten days of the festival,” he said. “‘The Etruscan Smile’ was hailed as a favorite. I was fortunate to have Brian Cox reach out to us just as we were finishing our schedule. He had been to the Stony Brook Film Festival for his film ‘The Carer’ and was keen on having the U.S. Premiere of ‘The Etruscan Smile’ at Stony Brook.”

The Stony Brook Film Festival has awarded eight Grand Prizes in its 23-year history. “The Etruscan Smile is the ninth to receive a Grand Prize.” 

And the winners are:

2018 Grand Prize 

“The Etruscan Smile” (United States)

U.S. Premiere 

Directed by Oded Binnun and Mihal Brezis. Written by Michael McGowan, Michal Lali Kagan and Sarah Bellwood. With Brian Cox (“Braveheart,” “The Carer”), Thora Birch (“Ghost World”), JJ Feild (“Austenland”) and Rosanna Arquette (“Pulp Fiction”). 

2018 Jury Award – Best Feature (tie) 

“Octav” (Romania)

U.S. Premiere 

Directed by Serge Ioan Celebidachi. Written by Serge Ioan Celebidachi and James Olivier. With Marcel Iures, Victor Rebengiuc, Eric Aradits and Alessia Tofan.

“Symphony for Ana” (Argentina)

East Coast Premiere 

Directed by Ernesto Ardito, Virna Molina. Written by Ernesto Ardito, Virna Molina and Gaby Meik. With Isadora Ardito, Rocio Palacin, Rafael Federman, Ricky Arraga, Vera Fogwill and Rodrigo Nova.

2018 Audience Choice – Best Feature 

“The Guilty’ (Denmark)

Directed by Gustav Möller. Written by Emil Nygaard Albertsen and Gustav Möller.With Jakob Cedergren, Jessica Dinnage and Omar Shargawi.

2018 Spirit of Independent Filmmaking  

“Thrasher Road” (United States) 

East Coast Premiere

Written and Directed by Samantha Davidson Green. With Allison Brown and Christian Kohn.

2018 Jury Award – Best Short

“Unnatural” (United States)

East Coast Premiere 

A film by Amy Wang. 

2018 Audience Choice Award – Best Short

“Internet Gangsters” (United States)

New York Premiere 

A film by Sam Friedlander. 

This year the films at the 2018 Stony Brook Film Festival spanned 19 different countries and the festival welcomed over 40 filmmakers to represent their films at screenings. With support from presenting sponsor Island Federal Credit Union and others, SBU was able to welcome guests from Israel, India, England, New Zealand, Spain, Belgium, and many from the West Coast.

The Closing Night Awards reception held in Staller Center’s Paul W. Zuccaire Gallery was sponsored by HBO. Catering for the reception was provided by The Meadow Club. 

Additional sponsors include Campolo, Middleton & McCormick, LLP; Altice Media Solutions, Suffolk County; and WLIW21. Staller Center Media Sponsors include WSHU Public Radio, Times Beacon Record News Media, WALK 97.5, LI News Radio and Oldies 98.1.

The Stony Brook Film Festival will announce the start date for 2019 entries later in the year at www.stonybrookfilmfestival.com.

Kenneth Shroyer and Luisa Escobar-Hoyos are the recent recipients of a two-year research grant from PanCAN. Photo by Cindy Leiton

By Daniel Dunaief

Stony Brook University has collected its first PanCAN award. Pathology Chair Kenneth Shroyer and Assistant Professor and Co-Director of the Pathology Translational Research Lab Luisa Escobar-Hoyos have earned a two-year $500,000 research grant from the Pancreatic Cancer Action Network.

The tandem has worked together for seven years on the protein keratin 17, or k17, which started out as an unlikely participant in pancreatic cancer and as a molecule cancer uses to evade chemotherapy.

Shroyer and Escobar-Hoyos were “thrilled to get the award,” said Shroyer in a recent email. “While we thought our proposal was very strong, we knew that this was a highly competitive process.”

Indeed, the funding level for the PanCAN grants program was between 10 and 15 percent, according to PanCAN.

The grants review committee sought to identify projects that “would constitute novel targets for treating pancreatic cancer,” said Maya Bader, the associate director of scientific grants at PanCAN. 

“Given that k17 represents a potential new target, the committee felt the project was a good fit with exciting potential to meet this goal. We are thrilled to welcome Dr. Shroyer to the PanCAN grantee research community and look forward to following both his and Dr. Escobar-Hoyos’ contributions to the field,” she said.

Escobar-Hoyos explained that she and Shroyer hope “this work will shed scientific insight into potential novel ways to treat the most aggressive form of pancreatic ductal adenocarcinoma,” which is the most common type of pancreatic cancer.

Although they are not sure if their approaches will be successful, she believes they will provide information that researchers can use to “further understand this aggressive disease.”

Thus far, Shroyer and Escobar-Hoyos have focused on the role of k17 in pulling the tumor suppressor protein p27 out of the nucleus into the cytoplasm, where it is degraded. More recently, however, they have explored how the k17 the tumor produces reprograms the cancer metabolome.

They have data that suggests that k17 impacts several dozen proteins, Escobar-Hoyos suggested. If the tumors of patients express k17, around half the protein content will go to the nucleus of the cell. 

In addition to understanding what k17 does when it enters the nucleus, Escobar-Hoyos and Shroyer are testing how they might stop k17 from entering the nucleus at all. Such an approach may prevent pancreatic cancer from growing.

Shroyer and Escobar-Hoyos are working with a graduate student in the lab, Chun-Hao Pan, who is testing molecular pathways that might make pancreatic cancer more resistant to chemotherapy.

Dr. Yusuf Hannun, the director of the Stony Brook Cancer Center, was pleased that his fellow Stony Brook scientists earned the PanCAN distinction.

“It is an important award and speaks to our growing significant efforts in research in pancreatic cancer,” he said, suggesting that the research could have important benefits for patients battling with pancreatic cancer.

“This defines at the very least a novel and important biomarker for pancreatic cancer that can also extend into novel therapeutic approaches,” Hannun said. This type of research could enhance the diagnostic process, allowing doctors to subtype pancreatic cancers and, if the pathways become clearer, enhance the effect of chemotherapy.

The funds from the PanCAN award will support experiments in cell culture and in animal models of pancreatic cancer, Shroyer explained.

Shroyer has teamed up with numerous researchers at Stony Brook and Cold Spring Harbor Laboratory on this work.

As proof of principle for one aspect of the proposal, he accessed chemosensitivity data from pancreatic cancer organoids. Hervé Tiriac, a research investigator who works in David Tuveson’s lab at CSHL, generated these organoids from SBU pancreatic cancer specimens.

In addition to their work with organoids at CSHL, Shroyer and Escober-Hoyos benefited from their collaboration with SBU’s Ellen Li, a professor of medicine, who ensured patient consent and specimen collection.

Going forward at Stony Brook University, the key collaborator for this project will be Richard Moffitt, an assistant professor in the departments of Biomedical Informatics and Pathology.

Shroyer described Moffitt as an “internationally recognized leader in the field of pancreatic cancer subtyping” who is working to understand better how k17 could serve as a prognostic biomarker.

At the same time, Wei Hou from the Department of Family, Population and Preventive Medicine will provide biostatistical support throughout the course of the project.

PanCAN, which has donated $48 million to support pancreatic cancer research, awarded nine grants this year in the United States, Canada and France, for a total contribution of $4.2 million. 

The other scientists include Andrew Aguirre from the Dana-Farber Cancer Institute, Scott Lowe, who had previously worked at Cold Spring Harbor Laboratory and is now at Memorial Sloan-Kettering Cancer Center and George Miller at New York University School of Medicine.

Previous recipients of PanCAN awards have been able to leverage the funds to attract research dollars to their work.

Grantees who had received $28.2 million from 2003 to 2015 went on to receive $311 million in subsequent funding to support their pancreatic cancer research, according to PanCAN. That means that every dollar awarded by PanCAN converts to $11.01 to fund future research aimed at understanding, diagnosing and treating pancreatic cancer, according to Bader. Most of the subsequent funding comes from government sources.

PanCAN award recipients have published research that other scientists have cited more than 11,000 times in other papers published in biomedical journals. This means “other researchers are reading, learning from and building upon our grantees’ work,” Bader added.

Stony Brook University baseball player Nick Grande slides into third. Photo from SBU Athletics

By Desirée Keegan

Nick Grande was home for a few weeks during winter break, and while his mother joked he could get a job during his extended stay, the shortstop had a different idea.

“No, mom,” he said in response. “As soon as the new year starts that’s it, you won’t see me again. I’ll be at Stony Brook every day.”

The Stony Brook University sophomore was a standout for Smithtown West’s baseball team, helping the Bulls claim two league titles during the three years he was team captain. He was named second team All-State as a senior after posting a .529 batting average, which also earned him the Suffolk County Silver Slugger Award. He also captained the league title-winning basketball team in his senior season. But while there are always adjustments to be made making the jump from high school to Division I college ball, his freshman season didn’t go as smoothly as he’d hoped.

Stony Brook University baseball player Nick Grande turns two. Photo from SBU Athletics

As a freshman at SBU, he played in 35 games, collecting multiple hits in seven of those contests. He notched his first collegiate hit and home run in the same game at Presbyterian College, and went 3-for-3 as the designated hitter in a win against Sacred Heart University. But he wanted to become more consistent, so he got up every morning during winter break at 8 a.m. to work on improving his game, and he did.

Grande batted .377 for the 32-25 Seawolves this past season. His 78 hits were the sixth most in a single season in Stony Brook history; his 32 stolen bases are the second most in a season only behind MLB-draftee Travis Jankowski’s 36 in 2012; he had 22 multi-hit games, including eight in a row; and reached base safely a team-best 22 straight games. Grande batted .418 in America East conference play and had five of his six home runs in conference.

“There’s a reason why people are talented,” said Nick Grande Sr., who was the head baseball coach and now principal at Island Trees High School. He recalled bringing his son to the field every day after school since he was 3 years old. “It’s all about the time they put into perfecting their craft … his desire, his determination. He hates to lose more than he loves to win, and that’s been since he was 3 years old.”

Although the elder Grande said his son has a fear of failure, he doesn’t show it. Grande Jr. said he’s picked up a philosophy of positivity along the way, from his time spent on the diamond at the age of 7 with his dad at the end of the day from his father’s Island Trees coaching job, to his new head coach Matt Senk, and everyone else he met along the way.

“You have to go into a game expecting to be successful — that’s the only way it’s going to work out of you, I think,” he said. “Even if you’re cold or having a tough day you have to step into the box knowing that you’re going to get a hit. I tried to have a positive mindset out there.”

“He hates to lose more than he loves to win, and that’s been since he was 3 years old.”

— Nick Grande Sr.

The starting shortstop earned back-to-back America East Player of the Week honors March 27 and April 3. He went 6-for-11 with a homer and three RBIs in a home series against the University of Massachusetts Lowell and went 6-for-6 with three doubles and a pair of RBIs in a win against Binghamton University. One of the nation’s top base stealers in 2018, he swiped three in a game twice. He went on to be named second-team ABCA/Rawlings Northeast All-Region, an America East spring scholar-athlete, a first-team Google Cloud Academic All-American and a first-team All-American by Collegiate Baseball.

“It was nice to be able to produce and contribute to help the team win games,” Grande said, adding it helped having role models like recent MLB draftees pitcher Aaron Pinto and infielder Bobby Honeyman and Coram outfielder Andruw Gazzola. “Being in a great lineup where top to bottom guys are having great at-bats didn’t hurt either.”

Despite his strong showing on the offensive side of the ball, Grande said he has a defense-first mentality.

“He’d rather catch a ground ball than get a base hit, and when he makes an error I hear about it for days,” Grande’s father said, laughing. “That’s because we’ve hit thousands of ground balls. He doesn’t stop, he doesn’t quit, and that’s because he wants to be as close to perfect as you can be.”

Senk said though that Grande wanted to be more of a consistent hitter to balance his game. He said he pointed out to his shortstop he had an inside-out swing that didn’t allow him to hit the ball as hard as he could, so he started pulling the ball more. Grande also practiced using his backhand to get to more ground balls.

Stony Brook University baseball player Nick Grande digs into the box. Photo from SBU Athletics

“He has such a tremendous work ethic — that was never an issue,” the SBU coach said. “He worked hardest in the toughest part of the game. He takes well to coaching, he kept working at it and working at it and ended up really clicking in a big way. I knew it when we were playing the defending national champs, University of Florida, and he hit a home run off first-round draft pick Brady Singer. From there his season took off. I think that was because of his dedication, athleticism and intelligence.”

But there’s more to the ballplayer than his devotion and talent. Smithtown West head coach Al Nucci said what he does in the classroom, and the kind of teammate he is makes him exemplary in every which way.

“He stood out from the day he started,” Nucci said of seeing Grande during a Booster Club practice as a youngster. “As crazy as it sounds as a young boy he had an incredible work ethic, he loved the game, he was always looking to improve, he smiled, he was super polite — as a 6-year-old on 60-foot diamond completely and totally standing out from his peers.”

He was pulled up to varsity as an eighth-grader to get more of a challenge, and ended up starting the second half of the season and into the playoffs after an injury sidelined one of his teammates. His coach joked that he might be the only Bulls player in history to hit a home run in his first at-bat and sacrifice bunt his next, showing his team-first mentality.

“He’s probably a better person and a better student than he is an athlete,” Nucci said. “He’s the first on the field and the last one off it, and he backs up his leadership skills and his work ethic with results on the field. And Nick didn’t need to speak — he spoke with his mitt, with his arm, with his bat, with his baseball intellect and with his attitude. Nick is the type of kid that takes a little something from everyone and uses it to his advantage. I hope my son ends up like Nick one day, I’ll tell you that.”

“He takes well to coaching, he kept working at it and working at it and ended up really clicking in a big way.”

— Matt Senk

Grande’s father said although it can be nerve-racking, it’s been nice to take off the coaching uniform and sit back and watch his son play.

“Your stomach is turning, you’re a nervous wreck, your hands are sweating, but there’s not a better place in the world to be than watching your kids play sports,” he said. “The sport to me always had such a positive effect on my life, and from an early age he seemed to be following in the same footsteps, that the game was going to be meaningful for him, too.”

Baseball is a game of highs and lows, and it’s those who turn the lows into highs that tend to become successful. Nick Grande is the epitome of that according to those who know him best.

“When you get a text from your son that says, ‘Dad, I was just chosen as first-team All-American,’ after you pick yourself up off the floor, you take a deep breath and say, ‘Wow, all of his hard work, all of his dedication really paid off for him,’” Grande Sr. said. “People that work hard deserve to be rewarded in life, and in his case he has.”

Stephanie Maiolino. Photo by Elizabeth Anne Ferrer

By Daniel Dunaief

This one’s a head scratcher, literally.

For years, people assumed early primates — small creatures that lived 55 million years ago — had nails. That, however, is not the complete story, as Stony Brook University Assistant Professor Stephanie Maiolino and a team of researchers discovered.

In addition to nails, which lay flat on our fingers and which make it easy to scratch an itch after a mosquito bite, earlier primates had something called grooming claws. These claws, which were on the toes next to their big toes, allowed them to remove external parasites like ticks and lice, which likely helped them survive against an onslaught of various critters eager to steal, or even infect, some of their blood.

Maiolino, who is in the Department of Anatomical Sciences at SBU, teamed up with lead author Douglas Boyer, an associate professor in the Department of Evolutionary Anthropology at Duke University; Johnathan Bloch, the Florida Museum of Natural History curator of vertebrate paleontology at University of Florida; Patricia Holroyd, a senior museum scientist at UC-Berkeley’s  Museum of Paleontology; and Paul Morse, from the Florida Museum of Natural History at the University of Florida at Gainesville to report their results recently in the Journal of Human Evolution.

“It was generally assumed that only a certain type of primate had grooming claws,” Maiolino said. “Finding these structures was quite surprising.”

Maiolino spent considerable time during her doctoral work, which she conducted at SBU prior to becoming an instructor at the university, analyzing the differences in the bones of species that have nails, claws and grooming claws. By understanding the anatomical features of the phalanges — or fingers and toes — leading up to the claws or nails, Maiolino was able to go back into the fossil record to explore the prevalence of these digit protrusions.

Oftentimes, she suggested, researchers collect a bone, or even a fragment of a bone, in which a nail or claw is almost never preserved in the fossil record. Maiolino used her analysis to extrapolate the parts that extend beyond the remaining fossils.

While nails sit on the end of fingers, grooming claws stick up, which puts them in an ideal position for combing through hair, which would allow the primates to remove pests that could compromise their health or threaten their survival.

“From a functional standpoint, it’s often overlooked how important the need to remove these parasites [is],” she said. When people see lemurs whose ears are completely covered in ticks or they hear about dogs that have so many ticks on them that the dog is at risk of dying, they recognize that “having an adaptation to help you remove them is actually surprisingly a big deal.”

Like any other adaptation, however, the development of these grooming digits comes with a cost. Instead of having that digit available for locomotion or grasping branches, it becomes more useful in removing unwanted insects. “There are significant pressures shaping the feet of these primates,” said Maiolino.

To provide some perspective on the importance of grooming claws, Maiolino highlighted how the primates from the fossil record were not much bigger than a mouse. Having less blood because they are smaller than current primates, and dealing with ticks that are closer to their size, suggests that the health consequences of an infestation are much greater.

As primates became more social — interacting with other members of their species and taking turns grooming each other — the pressure to have these grooming claws may have reduced.

Nonetheless, Maiolino said, a few primates that spend hours each day picking ticks off each other in a process called allogrooming still have these claws. “Some of the animals that do have [the claws] groom each other considerably,” she said, which suggests that there is still work to do to understand the evolution of these features.

When Maiolino and her collaborators first started exploring the claws versus nails discussion, they knew that researchers believed anthropoids didn’t have them.

“Now we know that anthropoids did,” she said. “We’re getting more of a sense of the distribution” of these claws.

From here, Maiolino would like to continue to explore the evolutionary trajectory from claw-bearing nonprimates to nail-bearing primates. There are a “lot of questions about why early primates ended up evolving nails in the first place,” she said.

William Jungers, a distinguished professor emeritus at Stony Brook University who was Maiolino’s doctoral thesis adviser, described her as “an outstanding and innovative young scientist with a very bright future as an educator and comparative anatomist.” He said Maiolino uses “cutting edge imaging methods to advance our understanding of primate origins and paleobiology, especially the evolution of unique aspects of primate hands and feet.”

Jungers explained that claws and nails are the “key features linked to both locomotion and social behavior.”

Maiolino, who currently lives in Port Jefferson, said when she visits zoos, she’s always on the lookout for the way primates and other mammals use their nails or claws. She also studies photographs and videos.

When she first started graduate school, Maiolino was much more interested in skulls than in nails. Once she linked nails and claws, however, to questions about primate origins, she became much more interested in them.

Outside of the lab, Maiolino said she enjoys watching horror movies. One of her favorites is the second “Aliens” film in the Signourney Weaver centered franchise. She is also a fountain pen enthusiast.

Back in high school in New Jersey, Maiolino  was especially interested in studying evolution. Embryology and embryological development appealed to her, as she was amazed by how growth in the womb affected what organisms became.

As for her work, a Holy Grail question for her would be to better understand why primates developed nails in the first place. She’s trying to understand the interplay between body size, behavior and other variables that affected these structures.

OLLI classes will be contained in the Social & Behavioral Sciences building, the Charles B. Wang Center, above, and Student Activities Center this fall. Photo from Stony Brook University

Continuing education students in Suffolk County recently found out speaking up can garner better results.

Students and workshop leaders enrolled in the Osher Lifelong Learning Institute at Stony Brook University, a program that offers workshops, lectures and activities to retired and semiretired individuals, breathed sighs of relief when SBU representatives informed them at a June 27 meeting at the university that all OLLI classes will remain on campus. A few months ago, due to increased enrollment of SBU and OLLI students, it was proposed by university representatives that some OLLI classes be held off campus and members were told they could no longer park in the lot reserved for staff and faculty.

“There are some questions. So, I think there’s room for tweaking here.”

— John Gobler

Judith Greiman, chief deputy to SBU president and senior vice president for government and community relations, said while all classes will be held on campus, they will only be scheduled Mondays, Wednesdays and Fridays instead of every weekday. Class duration will also be changing from 75 minutes to 60. OLLI students will be required to use the metered parking lots where they will need a hang tag, so they won’t have to put coins in the meters. The new parking arrangement will mean an added $75 in OLLI fees per semester.

The changes came after complaints from members and several meetings with Greiman, SBU community relations director Joan Dickinson and OLLI representatives, according to past OLLI president Robert Mirman. He said both sides had to bend a little.

“It’s understandable that the students of the university have priority, and they’re growing, there’s no ifs, ands or buts,” Mirman said. “But the majority of our members, the feedback that we got, was that they would prefer to be on campus.”

Workshop leader John Gobler said he believes the new plans are an improvement over initially proposed ideas, but said he and other members feel issues still exist. The new schedule has an hour break between classes, which will cause a good amount of downtime for those who take more than one course a day. He said at the June 27 meeting, members complained about the additional $75 a semester fee. Not everyone brings their car since they carpool, others need to park in handicap spots at the university and metered parking is limited, according to Gobler. Mirman said overall the $75 additional fee per semester will be less expensive than using the meters.

“The misperception, on the part of some, was that somehow the university didn’t want people on campus.”

—Judith Greiman

“We do have the support of the university, and they’re trying to help us, I’m sure,” Gobler said. “There are some questions. So, I think there’s room for tweaking here.”

Gobler also has concerns about equipment since classes will be offered solely in the Charles B. Wang Center, Student Activity Center and Social & Behavioral Sciences building, where the rooms don’t have the same technology equipment as other buildings. The one benefit of OLLI classes taking place in the three buildings instead of various buildings is OLLI members will know where their class location is as soon as they register. In the past, they had to wait until SBU
students completed registration to know where a class was going to be held.

Dickinson said current discussions with OLLI representatives has led to helping members become more involved with volunteer and community opportunities. She said many didn’t realize there were university events they could take part in like an international science competition where members can meet with the participating students and see their projects. She said many agencies in the community reach out to SBU and ask for help with reading to local students, musical performances, hosting campus tours and more. Those same volunteer opportunities will exist for OLLI members.

“Those kinds of connections and becoming more a part of the campus will be there,” Dickinson said.

Greiman said the university is happy to work with OLLI.

“The misperception, on the part of some, was that somehow the university didn’t want people on campus,” Greiman said. “In fact, we very strongly support the program and see the OLLI members as ambassadors and as part of the Stony Brook family.”

Knowing the signs of a stroke and getting help quickly can save your life.

By Ernest J. Baptiste

Ernest Baptiste

Stroke can affect people of all ages and backgrounds. When you have a stroke, you lose nearly two million brain cells for each minute that passes until normal blood flow is restored to your brain. No wonder it’s a leading cause of disability. It’s also the fifth-leading cause of death for both men and women in the United States.

We’re encouraged that there has been a decline in stroke deaths over the past few years — due in part to increased awareness of the signs of stroke, people seeking treatment faster and improvements in the types of treatments available — but our work is far from done.

Knowing the signs of stroke and getting help quickly can save your life or that of a loved one. Signs include sudden loss of balance, sudden loss of vision in one or both eyes, an uneven facial expression, numbness or weakness in one arm and/or leg or disrupted speech. If you suspect you’re having a stroke, call 911 immediately. Let the operator know and ask to be taken to a stroke center where advanced treatments are available.

It is certainly a testament to the advanced level of quality stroke care provided at Stony Brook University Hospital that our stroke center was recently certified by The Joint Commission as a Comprehensive Stroke Center — the highest level a stroke center can achieve. To receive this advanced certification, we underwent a rigorous screening process. 

This certification is awarded only to institutions that provide advanced care to patients with exceptional, around-the-clock treatment.

As the first and only certified Comprehensive Stroke Center in Suffolk County — the second on Long Island and one of only 11 in New York State — Stony Brook joins an elite group. Nationally, approximately 200 hospitals out of 5,800 have earned this designation.  

While we hope that you or someone you love never experiences a stroke, it’s important to know that you have the most advanced level of stroke care just minutes away at SBU. For the thousands of Long Islanders who survive a stroke and face a tough road ahead, we offer help as well. 

Our Stony Brook Stroke Support Group provides encouragement and feedback from others who can relate to a stroke survivor’s and/or their family member’s situation, as well as tips about helpful programs and resources.

Although this advanced certification is a significant achievement for Stony Brook University Hospital, it is our patients and the communities we serve who benefit the most from having this level of stroke care available close to home. As a certified comprehensive stroke center, we provide a level of care that few hospitals anywhere can match.

Ernest J. Baptiste is the chief executive officer at Stony Brook University Hospital.

Above, a battle scene shot at Benner’s Farm in East Setauket last summer.
Film showcased at SBU’s Staller Center for the Arts

By Talia Amorosano

The wait is over. On Sunday, June 24, an integral piece of U.S. and Long Island history will be revisited in the geographic location where much of it actually took place. At 7 p.m., the Stony Brook University’s Staller Center for the Arts, 100 Nicolls Road, Stony Brook, will host the first major public screening of “One Life to Give,” a film about the friendship and lives of young American heroes Benjamin Tallmadge and Nathan Hale, whose actions would lead to the creation of a Revolutionary spy ring based on the North Shore of Long Island.

Presented in the Main Theater, doors will open at 6:45 p.m. After a message from publisher Leah Dunaief, a short behind-the-scenes documentary will be shown followed by the main film screening. After a message from the creators, the evening will conclude with a Q&A with the cast and crew. Admission to the event is free, courtesy of TBR News Media. No reservations are necessary.

Cast and crew gather around a camera to view playback last summer.

The film’s co-producer and writer, Michael Tessler, describes the film as an exploration of historical events with a human focus. “After spending several years researching Benjamin Tallmadge and the other heroes featured in our film, I began to look at them not as detached names in a textbook, but more so as real people, with real stories that deserve to be told,” he said.

 Dave Morrissey, the actor who portrays Tallmadge in the film, describes his character as a “22-year-old kid,” who, despite his relative youth, is “focused” and “grounded,” propelled into action by the death of his brother at the hands of the British. “When something like that happens to you, you turn into a machine … into something else,” said Morrissey. “If you channel the energy and do what’s right, the possibilities are endless.”

By focusing a metaphorical macro lens on the multidimensional characters of Tallmadge and Hale, the film traverses consequential moments of American history: the Battle of Long Island, the anointing of America’s first spy and the events that would lead to the creation of the Culper Spy Ring, a group of men and women who risked their lives and status to gather British intelligence for the Revolutionary cause. 

Though Tessler notes that the film is, at its heart, a drama, he and the film’s director and co-producer Benji Dunaief stress the cast and crew’s commitment to accuracy in their interpretation of historical events. 

“The history comes second to the narrative in most [other film adaptations of historical events],” says Dunaief. “Our approach with this film was the exact opposite. We wanted to see where we could find narrative within [pre-existing] history.” 

“Many of the lines from the film were plucked directly from the diaries of the heroes themselves,” stated Tessler. “We worked closely with historians and Revolutionary War experts to achieve a level of accuracy usually unseen in such a local production.”

The fact that many scenes from the film were shot in the locations where the events of the real-life narrative took place helped give the visuals a sense of truthfulness and the actors a sense of purpose.

“The location took production to the next level. It’s really crazy how closely related the sets we used were to the actual history,” said Dunaief, who specifically recalls filming at a house that contained wood from Tallmadge’s actual home. “It helped to inspire people in the cast to get into character.” 

Morrissey recalls spending a particularly inspiring Fourth of July on Benner’s Farm in East Setauket. “We were filming the war scenes with all the reenactors … in the cabin that we built for the set … in the town where the battles and espionage had really happened. There were fireworks going on in the background while we sang shanty songs. It was amazing.”

The Continental Army shoots off a cannon at Benner’s Farm.

Though locational and historical accuracy played a large role in making filming a success, ultimately, Dunaief and Tessler credit the resonance of “One Life to Give” to an engaged and participatory community. “This was a community effort on all accounts,” says Dunaief, noting the roles that the Benners, Preservation Long Island, The Ward Melville Heritage Organization, the Three Village Historical Society and others played to bring “One Life to Give” to fruition. 

The fact that the screening will take place at the Staller Center, in the heart of the community that helped bring the film about, represents a full-circle moment for the cast and crew. “We’re calling it a screening but it is so much more,” said Dunaief. “It is a fantastic example of how the community has stood by this film, from beginning to end.”

“We’re beyond honored and humbled to use a screen that has seen some of the greatest independent films in history,” said Tessler. “Stony Brook University has been a wonderful partner and extremely accommodating as we work to bring our local history to life.” 

Tessler projects confidence that viewers will leave the screening with a similar sense of gratitude. “This story shows a part of our history that I think will make the audience very proud of the place they call home.”

The future of ‘One Life to Give’: 

Michael Tessler and Benji Dunaief plan to show the film at festivals around the country, to conduct a series of screenings on Long Island, and to partner with local historical societies that can use it as an educational tool. Additionally, a sequel to “One Life to Give,” titled “Traitor,” is already in the works. Filming will begin this summer.

All photos by Michael Pawluk Photography

Perry Gershon. Photo by Kyle Barr

As the five-headed Democratic Primary to select a challenger for 1st District U.S. Rep. Lee Zeldin (R-Shirley) nears, six Stony Brook University faculty members, some with ties to Brookhaven National Lab, have authored a letter endorsing their preferred winner.

The signers of the letter are throwing their public support behind Perry Gershon, a first-time candidate for political office from the private sector, who made a career as a commercial mortgage lender and small business owner, citing his belief that “facts trump opinions.” The group also supports Gershon’s broader dedication to protecting the environment.

The endorsement came with a disclaimer that the signees being affiliated with SBU are for identification purposes only and do not imply institutional support for any political candidate. Other notable endorsements in the race thus far include Suffolk County Legislator Al Krupski’s (D-Cutchogue) stated support for Kate Browning, a former legislator herself; and Legislator Kara Hahn (D-Setauket) and Brookhaven Town Councilwoman Valerie Cartright (D-Port Jefferson Station) backing Vivian Viloria-Fisher, another Suffolk legislature alumna. Notably, the group of six from SBU’s STEM department did not endorse BNL scientist Elaine DiMasi, who is also among the five candidates in the race.

The full letter from the SBU professors supporting Gershon is below, lightly edited for grammar and style.

Endorsement of Perry Gershon for Congress by faculty and researchers in science, technology, engineering and math at Stony Brook University and Brookhaven National Laboratory

An open letter to the community:

As faculty and researchers at Stony Brook University and Brookhaven National Laboratory  involved in science, technology, engineering and math (STEM) teaching and research, we believe it is of vital importance that you vote for Perry Gershon as your next U.S. Representative in Congress in New York’s 1st Congressional District June 26 in the Democratic Primary.

For all of us, at both the university and the lab in Brookhaven, mid-western Suffolk has been our home for many years, just as the South Fork in eastern Suffolk has been Perry’s home for over 20 years. CD1 covers both — we share the same aquifer and the same need for clean water. What happens here locally, in our country, and in the world, matters deeply to all of us.

We need Perry in Congress because he believes that facts trump opinions. Perry grew up in an academic family. His parents are both medical researchers at Columbia University. While a student at Yale, Perry was involved in original research as co-investigator on multiple published papers with faculty. He understands at his core that investigation and evidence must win out over demagoguery.

Perry believes in the overwhelming evidence of climate change and its profound effects at every scale, from Long Island to the entire Earth. Unlike President Donald Trump (R) and Zeldin, Perry would stay in the Paris Climate Accord and work to help America meet its goals. Perry holds that expanding markets for innovative clean technologies generates jobs and economic growth. Research at SBU, BNL, and Suffolk incubators can be at the forefront of turning CD1’s economy into one that supports good-paying, middle-class jobs that offer our young people the opportunity to stay on Long Island.

Perry knows that Environmental Protection Agency regulations, based on scientific study, are made to help and protect every one of us. Yet under Trump (R), EPA Administrator Scott Pruitt (R) and Zeldin, expert scientists are no longer even allowed to provide advice to the EPA, because recipients of EPA grants, who are the most knowledgeable experts, are forbidden from serving on EPA’s scientific advisory committees — the bodies that make sure regulations to protect public health and environmental values are based on sound science.

Perry knows that Department of the Interior decisions should benefit the country, not benefit any corporation that wants to exploit our natural resources for its bottom line. We do not need or want offshore oil drilling destroying our pristine coastline and threatening our tourist industry. While Zeldin feigns opposition, his support of Trump has allowed Zinke to move forward to expedite drilling permits.

Perry stands for the Democratic values that we all share: seeking truth and diversity of opinion. Unlike Trump and Zeldin, Perry actually listens. He actively seeks input and advice. His main goal is to solve problems in ways that benefit the greatest number of people.

On June 26, the Democratic Primary will choose the candidate who will oppose Zeldin in November. We firmly believe Perry Gershon has the intellect, the skills, the fortitude, and the resources to beat Zeldin — a powerful combination that is not matched by any of the other primary candidates.

We ask you to support Perry Gershon, to take back Congress by removing the man who has become Trump’s mouthpiece and enabler — Lee Zeldin. On June 26, please stand with us in returning truth to our government’s decision making.

Sincerely,

Dr. Douglas Futuyma, Distinguished Professor, Ecology and Evolution, SBU

Dr. Nancy Goroff, Chair Department of Chemistry, SBU

Dr. Stephen Baines, Associate Professor, Ecology and Evolution, SBU

Dr. Barry McCoy, Distinguished Professor, CN Yang Institute for Theoretical Physics, SBU

Dr. Lorna Role, Distinguished Professor and Chair, Neurobiology and Behavior, SBU

Dr. Gene Sprouse, Distinguished Professor Emeritus, Physics and Astronomy, SBU

This post was updated June 19 to remove Dr. Jeff Keister as a signer and add Dr. Stephen Baines.

From left, Evan Sohn, co-founder of the Sohn Conference Foundation; Benjamin Martin, associate professor at Stony Brook University; and Bill Ackman, co-founder of the Pershing Square Foundation and CEO of Pershing Square Capital Management at an awards dinner. Photo by Melanie Einzig/PSSCRA

By Daniel Dunaief

Up and coming scientists are often stuck in the same position as promising professionals in other fields. To get the funding for research they’d like to do, they need to show results, but to get results, they need funding. Joseph Heller, author of “Catch 22,” would certainly relate.

A New York-based philanthropy called the Pershing Square Sohn Cancer Research Alliance is seeking to fill that gap, providing seven New York scientists with $600,000 each over the course of three years.

In the fifth annual competition, Benjamin Martin, an associate professor in the Department of Biochemistry & Cell Biology at Stony Brook University, won an award for his study of zebrafish models of metastatic cancer. Martin is the first Stony Brook researcher to win the prize.

Working with Assistant Professor David Matus, whose lab is across the hall and whose research team conducts weekly group meetings with Martin’s lab, Martin is able to see in real time the way grafted human tumor cells spread through blood vessels to other organs in the transparent zebrafish.

“It’s been very challenging to understand what process cancer cells are using to metastasize and leave the blood vessels,” said Olivia Tournay Flatto, the president of the Pershing Square Foundation. “With this technology, he can see what’s happening. It’s a really powerful tool.”

The work Martin presented was “really appealing to the whole board, and everybody felt this kind of project” had the potential to bring data and insights about a process researchers hope one day to slow down or stop, said Flatto.

This year, about 60 early-stage investigators applied for an award given specifically to researchers in the New York City area. When he learned that he won, Martin said, “There was some dancing going on in the living room.” He suggested that the award is a “validation” of his research work.

The process of a cancer cell leaving a blood vessel is “basically a black box” in terms of the mechanism, Martin said. It’s one of the least understood aspects of metastasis, he added.

Indeed, a developmental biologist by training, Martin is hoping to discover basics about this cancer-spreading process, such as an understanding of how long it takes for cancer cells to leave blood vessels. The process can take hours, although it’s unclear whether what he’s seen is typical or abnormal.

Martin would like to identify how the cancer cells adhere to the blood vessel walls and how and why they leave once they’ve reached their target.

Metastatic cancer is likely using the same mechanism the immune system uses to travel to the sites of infection, although researchers still need to confirm several aspects of this model.

Moving in involves interactions with white blood cells, including macrophages. With white blood cells, an area of infection or inflammation becomes activated, which triggers a reaction of adhesion molecules called selectins.

By watching a similar transport process in cancer, Martin and Matus can “see things people haven’t seen before” and can explore way to inhibit the process, Martin suggested.

He is hoping to find ways to stop this process, forcing cancer cells to remain in the blood vessels. While he doesn’t know the outcome of a cancer cell’s prolonged stay in the vessel, he predicts it might end up dying after a while. This approach could be combined with other therapies to force the cancer cells to die, while preventing them from spreading.

Through this grant, Martin will also study how drugs or mutations in selectins generate a loss of function in these proteins, which affects the ability of cancers to leave the blood vessel.

Martin plans to use the funds he will receive to hire more postdoctoral researchers and graduate students. He will also purchase additional imaging equipment to enhance the ability to gather information.

Martin appreciates that this kind of research, while promising, doesn’t often receive funding through traditional federal agencies. This type of work is often done on a mouse, which is, like humans, a mammal. The enormous advantage to the zebrafish, however, is that it allows researchers to observe the movement of these cancer cells, which they couldn’t do in the hair-covered rodent, which has opaque tissues.

“There’s a risk that these experiments may not work out as we planned,” Martin said. He is hopeful that the experiments will succeed, but even if they don’t, the researchers will “learn a great deal just from seeing behaviors that have not been observed before.”

Indeed, this is exactly the kind of project the Pershing Square Sohn Cancer Research Alliance seeks to fund. They want scientists to “put forward the riskiest projects,” Flatto said. “We are ready to take a chance” on them.

One of the benefits of securing the funding is that the alliance offers researchers a chance to connect with venture capitalists and commercial efforts. These projects could take 20 years or more to go from the initial concept to a product doctors or scientists could use with human patients.

“We are not necessarily focused on them starting a company,” Flatto said. “We think some of those projects will be able to be translated into something for the patient,” which could be through a diagnosis, prevention or treatment. “This platform is helpful for young investigators to be well positioned to find the right partners,” he added.

Aaron Neiman, the chairman of the Department of Biochemistry & Cell Biology at SBU, suggested that this award was beneficial to his department and the university.

“It definitely helps with the visibility of the department,” Neiman said. The approach Matus and Martin are taking is a “paradigm shift” because it involves tackling cells that aren’t dividing, while many other cancer fighting research focuses on halting cancer cells that are dividing.

Neiman praised the work Martin and Matus are doing, suggesting that “they can see things that they couldn’t see before, and that’s going to create new questions and new ideas,” and that their work creates the opportunity to “find something no one knew about before.”

From left, Libo Wu, Zhangjie Chen (both are doctoral students on the ARPA-E project), Ya Wang, Xing Zhang (graduated), Muzhaozi Yuan and Jingfan Chen (both are doctoral students on the NSF project). Photo courtesy of Stony Brook University

By Daniel Dunaief

Picture a chalkboard filled with information. It could include everything from the basics — our names and phone numbers, to memories of a hike along the Appalachian Trail, to what we thought the first time we saw our spouse.

Diseases like Alzheimer’s act like erasers, slowly moving around the chalkboard, sometimes leaving traces of the original memories, while other times removing them almost completely. What if the images, lines and words from the chalk could somehow be restored?

Ya Wang with former student Wei Deng at Stony Brook’s Advanced Energy Research and Technology Center. Photo courtesy of SBU

Ya Wang, a mechanical engineering assistant professor at Stony Brook University, is working on a process that can regenerate neurons, which could help with a range of degenerative diseases. She is hoping to develop therapies that might restore neurons by using incredibly small magnetic nanoparticles.

Wang recently received the National Science Foundation Career Award, which is a prestigious prize given to faculty in the early stages of their careers. The award lasts for five years and includes a $500,000 grant.

Wang would like to understand the way small particles can stimulate the brain to rebuild neurons. The award is based on “years of effort,” she said. “I’m happy but not surprised” with the investment in work she believes can help people with Alzheimer’s and Parkinson’s diseases.

“All neuron degeneration diseases will benefit from this study,” Wang said. “We have a large population in New York alone with patients with neuron degeneration diseases.” She hopes the grant will help trigger advancements in medicine and tissue engineering.

Wang’s “work on modeling the dynamic behavior of magnetic nanoparticles within the brain microenvironment would lay the foundation for quantifying the neuron regeneration process,” Jeff Ge, the chairman and professor of mechanical engineering, said in a statement.

Wang said she understands the way neurodegenerative diseases affect people. She has watched her father, who lives in China, manage through Parkinson’s disease for 15 years.

Ge suggested that this approach has real therapeutic potential. “This opens up the exciting new possibility for the development of a new microchip for brain research,” he said.

At this point, Wang has been able to demonstrate the feasibility of neuron regeneration with individual nerve cells. The next step after that would be to work on animal models and, eventually, in a human clinical trial.

That last step is a “long way” off, Wang suggested, as she and others will need to make significant advancements to take this potential therapeutic breakthrough from the cell stage to the clinic. 

She is working with a form of coated iron oxide that is small enough to pass through the incredibly fine protective area of the blood/brain barrier. Without a coating, the iron oxide can be toxic, but with that protective surface, it is “more biofriendly,” she said.

The size of the particles are about 20 nanometers. By contrast, a human hair is 80,000 nanometers thick. These particles use mechanical forces that act on neurons to promote the growth or elongation of axons.

Ya Wang. Photo from SBU

As a part of the NSF award, Wang will have the opportunity to apply some of the funds toward education. She has enjoyed being a mentor to high school students, some of whom have been Siemens Foundation semifinalists. Indeed, her former students have gone on to attend college at Stanford, Harvard and Cal Tech. “I was very happy advising them,” she said. “High school kids are extremely interested in the topic.”

A few months before she scored her NSF award, Wang also won an Advanced Research Projects Agency–Energy award for $1 million from the Department of Energy. In this area, Wang also plans to build on earlier work, developing a smart heating and cooling system that enables a system to direct climate control efforts directly at the occupant or occupants in the room.

Extending on that work, Wang, who will collaborate in this effort with Jon Longtin in the Department of Mechanical Engineering at SBU and Tom Butcher and Rebecca Trojanowski at Brookhaven National Laboratory, is addressing the problem in which the system no longer registers the presence of a person in the room.

Wang has “developed an innovation modification to a simple, inexpensive time-honored position sensor, but that suffers from requiring that something be moving in order to detect motion,” Longtin explained in an email. The sensors can’t detect a person that is not moving. The challenge, Longtin continued, is in fooling the sensor into thinking something is there in motion to keep it active.

Wang described a situation in which a hotel had connected an occupant-detecting system to its HVAC system. When a person fell asleep in the room, however, the air conditioning turned off automatically. On a hot summer night, the person was frustrated. She put colored paper and a fan in front of the sensor, which kept the cool air from turning off.

Instead of using a fan and colored paper, the new system Wang is developing cuts the flow of heat to the sensor, which enhances its ability to recognize stationary or moving people.

Wang and her colleagues will use low-power liquid crystal technology with no moving parts. “The sensor detects you because you are a human with heat,” she said. “Even though you are not moving, the amount of heat is changing.”

The sensor will be different in various locations. People in Houston will have different temperature conditions than those in Wisconsin. Using a machine-learning algorithm, Wang said she can pre-train the system to respond to different people and different conditions.

She has developed a smart phone app so that the house can react to the different temperature preferences of a husband and wife. People can also choose night or day modes.

Wang also plans to work on a system that is akin to the way cars have different temperature zones, allowing one side of the car to be hotter than the other. She intends to develop a similar design for each room.

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