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METRO photo

By Nancy Burner, Esq.

Nancy Burner, Esq.

Not all estates require a probate or full administration proceeding. A small estate proceeding,  also known as a Voluntary Administration, is a simplified Surrogate’s Court procedure. 

What estates qualify?

The  Voluntary Administration is available if the decedent passed away with $50,000 or less in  personal property. Personal property includes cars, cash, stocks — anything but real estate. The Voluntary Administration proceeding is not an option when the decedent owned real  property solely in their own name. It is available if the decedent died with or without a Will.  

Voluntary Administration is not only for decedents who had minimal assets. Sometimes  only certain assets were owned by the decedent in their sole name. This happens often with  married couples with joint bank accounts or who own real estate with rights of survivorship. A decedent may have named beneficiaries on most of their accounts. In such cases only some  property needs to pass through Surrogate’s Court. Other times a decedent conveyed most, but not all, of their property to a trust. If the assets left outside the trust are less than  $50,000, a Voluntary Administration is available.  

How to file

The small estate proceeding is initiated by filing of an “Affidavit of Voluntary  Administration.” The Petitioner is either the nominated Executor in the decedent’s Will or  the closest living relative when there is no Will. The Petitioner is asking the Court for the  authority to collect the decedent’s assets, pay off any debts, and distribute the property to  those with a legal right to inherit. If there was a Will, the beneficiaries named in the Will  inherit. If there was no Will, then the estate passes under the laws of intestacy. 

The Voluntary Administration Proceeding is less complex than a probate or full  administration proceeding. Consent and Waiver is not required from the decedent’s  distributees (heirs who will inherit under the estate). The Court only provides the  distributees with notice that the proceeding was filed. This avoids the expense of costly  litigation over the appointment of a fiduciary.  

Drawbacks

The Voluntary Administration Proceeding has some drawbacks. The appointed  Administrator only has the authority to collect the specific assets listed on the Affidavit of  Voluntary Administration. Such broad authority is only available in a full probate or  administration proceeding. The Administrator does not have the broad authority to collect  and distribute any additional assets. If the Administrator finds assets not listed on the initial Affidavit, they have to go back to the court. 

Further, if the assets exceed $50,000, the Administrator must convert the proceeding to a full probate or Administration. For this reason, when there is uncertainty about the assets, it may be wise to proceed with a full  probate or administration proceeding.  

A small estate proceeding costs only $1 to file. While the Voluntary Administration  Proceeding is simple and inexpensive, mistakes can be costly. It is always a good idea to  consult with an experienced Estate attorney to ensure that a small estate proceeding is the  best way to proceed. 

Nancy Burner, Esq. is the founder and managing partner at Burner Law Group, P.C with offices located in East Setauket, Westhampton Beach, New York City and East Hampton.

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Update: Leo has been adopted! Happy life sweet boy!

MEET LEO!

This week’s shelter pet is Leo, an 11-month-old lab mix currently waiting for his furever home at the Smithtown Animal Shelter. This handsome man is as sweet as can be. He has lived with two smaller dogs and a cat and did well with all of them. He is timid, so he would do best with children over 12 years old. Leo has some issues with separation anxiety and will need a home that can help him manage that. He would be a perfect addition to any family.  

If you would like to meet Leo, please call ahead to schedule an hour to properly interact with him in a domestic setting.

The Smithtown Animal & Adoption Shelter is located at 410 Middle Country Road, Smithtown. Visitor hours are currently Monday to Saturday from 10 a.m. to 3 p.m. (Sundays and Wednesday evenings by appointment only). 

For more information, call 631-360-7575 or visit www.smithtownanimalshelter.com.

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Toby. Photo from Smithtown Animal Shelter
Update: Yay! Toby has been adopted!

This week’s featured shelter pet is Toby, a 12-year-old Chihuahua mix currently up for adoption at the Smithtown Animal Shelter. 

This sweet senior has not had an easy life.  He has been bounced from a few homes through a rescue in Florida and landed himself in Smithtown after getting loose on a busy road a few times.

Toby is very gentle and low key and is looking for the best possible home to show him some stability for his golden years. He gets along with everyone, but will need gentle dogs or older kids that will not pounce on him. He loves to go for walks and just be around people.  

If you would like to meet Toby, please call ahead to schedule an hour to properly interact with him in a domestic setting.

The Smithtown Animal & Adoption Shelter is located at 410 Middle Country Road, Smithtown. Visitor hours are currently Monday to Saturday from 10 a.m. to 3 p.m. (Sundays and Wednesday evenings by appointment only). For more information, call 631-360-7575 or visit www.townofsmithtownanimalshelter.com.

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Symptoms of diverticular disease include fever and abdominal pain. METRO photo
Focusing on fiber can provide dramatic results

By David Dunaief, M.D.

Dr. David Dunaief

Diverticular disease, or diverticulosis, is a common malady that affects us as we age. Thirty-five percent of U.S. 50-year-olds are affected and, for those over the age of 60, approximately 58 percent are affected (1). The good news is that it is potentially preventable through modest lifestyle changes. Here, I will explain simple ways to reduce your risk, while also debunking a pervasive myth — that fiber, or more specifically nuts and seeds, exacerbates the disease.

What is diverticular disease? 

Diverticular disease is the weakening of the lumen, or wall of the colon, resulting in the formation of pouches or out-pocketing referred to as diverticula. The cause of diverticula may be attributable to pressure from constipation. Its mildest form, diverticulosis may be asymptomatic. 

For those who experience symptoms, they may include fever and abdominal pain, predominantly in the left lower quadrant in Western countries, or the right lower quadrant in Asian countries. It may need to be treated with antibiotics.

Diverticulitis affects 10 to 25 percent of those with diverticulosis. Diverticulitis is inflammation and infection, which may lead to a perforation of the bowel wall. If a rupture occurs, emergency surgery may be required.

Unfortunately, the incidence of diverticulitis is growing. As of 2010, about 200,000 are hospitalized for acute diverticulitis each year, and roughly 70,000 are hospitalized for diverticular bleeding (2). For those between 40 and 49 years old, the incidence of diverticulitis grew 132 percent between 1980 and 2007, the most recent data on this population (3).

How do you prevent diverticular disease and its complications? 

There are a number of modifiable risk factors, including diet composition, including fiber intake, along with weight and physical activity.

In a study that examined lifestyle risk factors for diverticulitis incidences, adhering to a low-risk lifestyle reduced diverticulitis risk almost 75 percent among men (4). The authors defined a low-risk lifestyle as including fewer than four servings of red meat a week, at least 23 grams of fiber a day, two hours of vigorous weekly activity, a body mass index of 18.5–24.9 kg/m2, and no history of smoking. They estimated that a low-risk lifestyle could prevent 50 percent of diverticulitis cases. 

Examining fiber’s effects

In terms of fiber, there was a prospective study published online in the British Medical Journal that extolled the value of fiber in reducing the risk of diverticular disease (5). This was part of the EPIC trial, involving over 47,000 people living in Scotland and England. The study showed a 31 percent reduction in risk in those who were vegetarian. 

But more intriguing, participants who had the highest fiber intake saw a 41 percent reduction in diverticular disease. Those participants in the highest fiber group consumed >25.5 grams per day for women and >26.1 grams per day for men, whereas those in the lowest group consumed fewer than 14 grams per day. Though the difference in fiber between the two groups was small, the reduction in risk was substantial. 

Another study, which analyzed data from the Million Women Study, a large-scale, population-based prospective UK study of middle-aged women, confirmed the correlation between fiber intake and diverticular disease, and further analyzed the impact of different sources of fiber (6). The authors’ findings were that reduction in the risk of diverticular disease was greatest with high intake of cereal and fruit fiber.

Most Americans get about 16 grams of fiber per day. The Institute of Medicine (IOM) recommends daily fiber intake for those <50 years old of 25-26 grams for women and 31-38 grams for men (7). Interestingly, their recommendations are lower for those who are over 50 years old.

Can you imagine what the effect is when people get at least 40 grams of fiber per day? This is what I recommend for my patients. Some foods that contain the most fiber include nuts, seeds, beans and legumes. In a 2009 study, those men who specifically consumed the most nuts and popcorn saw a protective effect from diverticulitis (8).

Obesity’s impact

In the large, prospective male Health Professionals Follow-up Study, body mass index played a significant role, as did waist circumference (9). Those who were obese (BMI >30 kg/m²) had a 78 percent increased risk of diverticulitis and a greater than threefold increased risk of a diverticular bleed compared to those who had a BMI in the normal range of <21 kg/m². For those whose waist circumference was in the highest group, they had a 56 percent increase risk of diverticulitis and a 96 percent increase risk of diverticular bleed. Thus, obesity puts patients at a much higher risk of diverticulosis complications.

Increasing physical activity

Physical activity is also important for reducing the risk of diverticular disease, although the exact mechanism is not yet understood. Regardless, the results are impressive. In a large prospective study, those with the greatest amount of exercise were 37 percent less likely to have diverticular disease compared to those with the least amount (10). Jogging and running seemed to have the most benefit. When the authors combined exercise with fiber intake, there was a dramatic 256 percent reduction in diverticular disease risk. 

Thus, if you are focused on preventing diverticular disease and its complications, lifestyle modifications may provide the greatest benefit.

References: 

(1) www.niddk.nih.gov. (2) Clin Gastroenterol Hepatol. 2016; 14(1): 96–103.e1. (3) Gastroenterology. 2019;156(5): 1282-1298. (4) Am J Gastroenterol. 2017; 112: 1868-1876. (5) BMJ. 2011; 343: d4131. (6) Gut. 2014 Sep; 63(9): 1450–1456. (7) Am J Lifestyle Med. 2017 Jan-Feb; 11(1): 80–85. (8) AMA 2008; 300: 907-914. (9) Gastroenterology. 2009;136(1): 115. (10) Gut. 1995;36(2): 276.

Dr. David Dunaief is a speaker, author and local lifestyle medicine physician focusing on the integration of medicine, nutrition, fitness and stress management. For further information, visit www.medicalcompassmd.com.

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South of the Border Chicken

By Barbara Beltrami

When in doubt — whether company is coming for dinner, whether you have house guests, whether you’ve spent the day at the beach, whether you’re on a staycation, whether it’s just too darn hot to even think of turning on the stove or oven, whether you just can’t do another takeout, or whether you simply cannot think what to make for dinner — throwing some chicken on the grill is the default solution.

If you think of it early enough, you can marinate just about any chicken parts in the fridge while you go about your activities. If you decide too late for that, you can pick up the chicken, raid your herb garden or fridge and create a tasty main dish that’s sure to please even the fussiest guests or family members.

Pollo al Mattone (Chicken Under a Brick)

YIELD: Makes 4 servings

INGREDIENTS: 

2 bricks, wrapped in aluminum foil

One 4-pound chicken

1/4 cup olive oil

1/4 cup dry white wine

4 garlic cloves, chopped

1 1/2 tablespoons chopped rosemary

Freshly squeezed juice from 1/2 lemon

Coarse salt and pepper, to taste

1 teaspoon dried hot red pepper flakes

DIRECTIONS:

Prepare grill to medium, then place bricks on grill to heat up. Remove neck , extra fat, and innards from chicken and discard or save for another use. Place chicken, breast side down on a cutting board and, with poultry shears or a large knife, cut along both sides of spine and remove it. Cut the breast in half lengthwise. Wash chicken in cold water and pat dry with paper towels. 

In a small bowl, combine oil, wine, garlic, rosemary, lemon, salt and pepper and hot pepper flakes. With a pastry brush coat the entire chicken with the mixture. Place chicken halves, skin side down on grill;  place a heated brick on top of each half, close lid and cook for about 10-15 minutes, until skin is crisp and there are dark grill marks\.

Remove bricks, flip the chicken, put bricks back on top and continue to cook  another 10-15 minutes or so, until a meat thermometer inserted at thigh joint reads 170F. Transfer chicken to cutting board and let sit about 5 minutes, then cut into 4 pieces.  Serve with corn on the cob and a tossed salad.

South of the Border Grilled Chicken

YIELD: Makes 4 servings

INGREDIENTS: 

4 skinless boneless chicken breasts

1/4 cup olive oil

2 garlic cloves, minced

2 tablespoons chili powder

2 teaspoons ground cumin

2 teaspoons ground coriander

1 teaspoon paprika

1 tablespoon freshly squeezed lime juice

Coarse salt and pepper to taste

Crushed hot red pepper flakes

Lime wedges

DIRECTIONS:

Butterfly each chicken breast by slicing it almost in half horizontally, then opening it like a book so it lies flat. In a large bowl combine the oil, garlic, chili powder, cumin, coriander, paprika, lime juice, salt and pepper and pepper flakes. Place chicken in bowl and rub it all over with the mixture. Cover and refrigerate 30 minutes. Preheat grill to medium. Use marinade to baste only during first 5 minutes of cooking as it has been in contact with raw chicken and must be thoroughly cooked; grill chicken, turning once, until just turning brown but not dark, about 5-10 minutes per side. Serve immediately with lime wedges, salsa and a salad or cover and refrigerate until ready to serve.

Curried Grilled Chicken

YIELD: Makes 4 servings

INGREDIENTS:

3 tablespoons olive oil

2 tablespoons prepared mustard

2 tablespoons warm honey

1 tablespoon curry powder

Salt and freshly ground pepper to taste

1 small onion, minced

1 garlic clove, minced

1/2 teaspoon cinnamon

4 boneless chicken thighs

1/4 cup fresh cilantro leaves, chopped

DIRECTIONS:

Preheat grill to medium. In a large bowl combine oil, mustard, honey, curry powder, salt and pepper, onion, garlic, and cinnamon. Place chicken thighs in bowl and toss to coat evenly with mixture. Place chicken on grill and baste with marinade only during first 5 minutes as it has been in contact with raw chicken and must be thoroughly cooked. Grill, turning once, until cooked through and meat thermometer inserted in thickest part of thigh reads 170 F. Sprinkle cilantro  over chicken and serve immediately with rice and grilled peaches.

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Sebastian (Derek Hough) serenades Prince Eric (Brody Hampson) and Ariel (Dori Ahlgrim) in 'Kiss the Girl'. Photo from SPAC

By Heidi Sutton

This summer, families will have the opportunity to swim under the sea with Ariel and all her friends as the Smithtown Center for the Performing Arts presents one of Disney’s most beloved classics, The Little Mermaid Jr. 

From the moment you step into the historic theater you know you are in for a real treat. Decorated with shells and coral, the lobby beckons visitors to an afternoon of live theater as little Ariels and fellow princesses make their way to their seats. The set is equally impressive, with long blue panels affixed with coral and netting representing the kingdom of Atlantica. Once the show begins, every flawless scene delights with wonderful acting, singing and dancing by a cast of 20 young budding actors. Sitting in the balcony, I kept thinking how this could easily be a main stage production.  

Ariel (Dori Ahlgrim) sings ‘Part of Your World’. Photo from SPAC

With music by Alan Menken, book by Doug Wright and lyrics by Howard Ashman and Glenn Slater, the show, which opened last Saturday afternoon, begins with the seafaring number “Fathoms Below” and keeps the audience on the edge of their seats until the very end. 

Directed and choreographed by Ryan Nolin, with musical direction by Robbie Torres, the story centers around Princess Ariel, the youngest mermaid daughter of King Triton, who is obsessed with the world above and longs to trade in her fish tail for a pair of legs, much to the dismay of her father. 

When she falls in love with Prince Eric, Ariel strikes a bargain with her aunt, the evil sea witch Ursula, to become human. There is a catch however — Ariel must give up her voice and Eric must fall in love with her in three days or she will lose her soul forever. With the help of her best friend Flounder, the court composer Sebastian the crab, and a seagull named Scuttle, Ariel sets off to follow her heart. But things do not go as planned.

Ariel (Dori Ahlgrim) and Prince Eric (Brody Hampson) in a scene from the play. Photo from SPAC

Dori Ahlgrim is perfectly cast as the free spirited Ariel. With a beautiful singing voice, her solo, “Part of Your World” brings the house down. As Prince Eric, Brody Hampson holds his own with the endearing number “One Step Closer” where he teaches a mute Ariel how to dance.

Molly Sanges is wonderful as Ariel’s best friend Flounder and Gianna Oppedisano is a delightful Scuttle in “Human Stuff.”

Special mention must also be made of Derek Hough as the crabby crustacean Sebastian who shines in the big dance numbers “Under the Sea” with mermaids and jellyfish and “Kiss the Girl” in a race against time as the sun goes down. 

The big number ‘Under the Sea’. Photo from SPAC

Other standout performances include Jenna Hammelman as the heartless Ursula who belts out a superb rendition of “Poor Unfortunate Souls” and Gabby Blum and Kieran Brown as the slippery slithering electric eels Jetsam and Flotsam who show up when least expected to create havoc. In the second act, Luke Hampson, French accent and all, gives a hilarious performance as Chef Louis in “Les Poissons.”

Costumes by Liz Honig are on point, from the black and white sailors costumes to the bright, bold and sparkly mermaid outfits. The set, along with King Triton’s kingdom, switches flawlessly from Ariel’s grotto to Ursula’s lair to Prince Eric’s castle. Kudos to the set production team. As an added bonus, a large screen in the background changes with the scenery and adds a third dimension to the story. 

Members of the cast will stay after the show for photos and shell wands and tiaras are sold in the lobby. Proceeds from the merchandise will benefit the restoration of the historic theater.

The Cast: Brody Hampson, Ari Spiegel, Ryan Romanelli, Derek Hough, Marilena Castoro, Selin Kazdal, Hannah Waller, Alia Romanelli, Emmerson Lebrecht, Nicole Sasbon, Molly Sanges, Dori Ahlgrim, Gianna Oppedisano, Gabby Blum, Kieran Brown, Jenna Hammelman, Luke Hampson, Allison Heidrich, Michael Gualtieri and Alexa Oliveto

The Smithtown Center for the Performing Arts, 2 E. Main St., Smithtown presents Disney’s The Little Mermaid Jr. through July 24. Costumes are encouraged. Running time is one hour and 30 minutes. Tickets are $25 per person. For more information or to order, visit www.smithtownpac.org.

 

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'The Goonies'

Middle Country Public Library, 101 Eastwood Blvd., Centereach will present the following free outdoor events for the community this summer:

Music Under the Stars: Petty Rumours

Thursday, July 12 from 7 to 8:30 p.m.

Join Petty Rumours for an unforgettable evening of music. This show will bring together over four decades of hits from Tom Petty, Stevie Nicks, Fleetwood Mac and the Traveling Wilburys. As this concert will be held outside, patrons should bring their own chairs and/or blankets. Food trucks will be on hand beginning at 6pm and performance begins at 7 p.m.

Music Under the Stars: 20 Highview

Tuesday, August 9 from 7 to 9 p.m.

Get down with 20 Highview, a nine-piece powerhouse band specializing in dance classics with funk grooves. They will cover classics from the 60’s up to the present day. As this concert will be held outside, patrons should bring their own chairs and blankets. Food trucks will be on hand beginning at 6pm and performance begins at 7 p.m.

MCPL Under the Stars Movie Night: ‘The Goonies’

Wednesday, August 17 from 8 p.m. to 10 p.m.

Join us for an outdoor viewing of the movie, The Goonies! As this movie will be held outside, patrons should bring their own chairs and blankets. In the event of rain, the program will be rescheduled for August 25. Food truck will be on hand beginning at 7 p.m. and movie begins at 8 p.m.

For more information, call 631-585-9393

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'Row Me Away' by Jan Guarino

*This article has been updated on July 7, 2022.

The Huntington Historical Society will present a series of summer art workshops for adults at the Conklin Barn, 2 High Street, Huntington starting on July 12:

Collaging 

GIVEN BY: ANNE FOX 

Free yourself of the usual art rules with Paper Collage. Merely with a pair of scissors, glue, and some maga zines, you can let your imagination fly and create a colorful work of art. Do abstract, do figurative, do land scapes. Let the scissors and your imagination be your guides. 

Tuesday, July 12th 1-3 pm or Tuesday, July 26th 1-3 pm 

Member price $35 Non-member price $45, Class size limited to 15 

Fearless Watercolors  – Only one spot left!

GIVEN BY: JAN GUARINO 

Artist Jan Guarino

I was once you… Struggling to become a better watercolorist and felt I was missing many of the basics needed  to be excel. Having taught watercolors for the past 15 years I know what you need and can help you build your  painting skills with specific techniques, my clear process to putting paint and water to paper will help you  more successfully express your passion for this medium. I’ll teach you in a way that emulates what I needed  as a student and didn’t get. This Basics Workshop takes many pieces and pulls them together in this 3-evening  workshop. Learn the correct brush strokes, understand color wheel, avoid muddy results, saving and correcting  whites and much more. The outcome will be that you become empowered by clear and innovative ideas. You  already have the passion and desire, combined with my suggestions ~ you can become a more confident water colorist. All it takes is you and practice! 

*Three Wednesday nights-3-part series, 6:30-9:00 pm, *July 27th, August 3rd, August 10th Member price $120, non-member price $150, Class size limited to 20 

Calligraffiti  

GIVEN BY: HELEN MURDOCK-PREP 

We all know how to type and text— but let’s get back to the power of the pen by learning the Art of Beautiful  Handwriting in this style called, Calligraffiti! Using a brush marker, we’ll have fun expressing ourselves in  this exciting, cursive lettering form that adds bold graffiti elements to make our words pop! Thursday, July 28th 1-3 pm or Thursday, August 11th 7-9pm  

Member price $35 Non-member price $45, Class size limited to 20

*Day time workshops – coffee, tea and delicious baked goods will be served!

*Night time workshops- wine, seltzer, fruit and cheese will be served!

For more information or to register, visit www.huntingtonhistoricalsociety.org.



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Markus Seeliger, third from left, with members of his lab, from left, Terrence Jiang. Aziz Rangwala, Ian Outhwaite, Victoria Mingione,YiTing Paung, and Hannah Philipose. Photo from Markus Seeliger

By Daniel Dunaief

When a dart hits the center of a target, the contestant often gets excited and adds points to a score. But what if that well-placed dart slipped off the board before someone could count the points, rendering such an accurate throw ineffective?

With some cases of cancer treatments, that’s what may be happening, particularly when a disease develops a mutation that causes a relapse. Indeed, people who have chronic myeloid leukemia typically receive a treatment called Imatinib, or Gleevac.

The drug works, hitting a target called a kinase, which this white blood cell cancer needs to cause its cells to continue to divide uncontrollably. Patients, however, develop a mutation called N368S, which reduces the effectiveness of the drug.

While mutations typically make it more difficult for a drug to bind to its target, that’s not what’s happening with this specific mutation. Like the dart hitting the center of a board, the drug continues to reach its target.

Instead, in a model of drug resistance several scientists have developed, the mutation causes the drug to decouple.

Pratyush Tiwary with this year’s US top 20 students who are going to the international chemistry olympiad. Photo from Toward

A team of experimental and computational researchers including Markus Seeliger, Associate Professor of Pharmacological Sciences at Stony Brook University, and Pratyush Tiwary, Associate Professor in the Department of Chemistry & Biochemistry at the University of Maryland, published two research papers explaining a process that may also affect the way mutations enable resistance to other drugs.

Seeliger described how different disease-associated mutations bind to Gleevac in a paper published in the Proceedings of the National Academy of Sciences. 

Working with scientists at Memorial Sloan Kettering Cancer Center and Goethe University in Frankfurt, Germany, Seeliger used nuclear magnetic resonance spectroscopy, or NMR. The researchers showed how the drug bound to its target and then released.

Understanding the way diseases like cancer develop such resistance could affect drug discovery, giving pharmaceutical companies another way to prepare for changes diseases make that reduce the effectiveness of treatments.

A ‘hot paper’

Tiwary published research in which Seeliger was a coauthor in late April in the journal Angewandte Chemie that the publication labeled a “hot paper” for its implications in the field. Tiwary developed a way to simulate the kinetic processes that enable the mutated kinases to release the drug.

Tiwary created an artificial intelligence model that extended the time he analyzed the drug-protein interaction from milliseconds all the way out to thousands of seconds.

“Even within the simulation world, if you can quantitatively predict a binding affinity, that’s amazing,” Seeliger said. “It’s extremely hard to calculate kinetics, and he got that right.”

Tiwary, who started talking with Seeliger about five years ago and has been actively collaborating for about three years, uses experimental data to inform the dynamics that affect his simulations.

Seeliger “had done the experiments of the dissociation rates beforehand, but did not have a way to explain why they were what they were,” Tiwary explained in an email. “Our simulations gave him insights into why this was the case and … insight into how to think about drugs that might dissociate further.”

Drug discovery

Tiwary hopes the work enables researchers to look at structural and kinetic intermediates in reactions, which could provide clues about drug design and delivery. While he worked with a single mutation, he said he could conduct such an analysis on alterations that affect drug interactions in other diseases.

He wrote that the computations, while expensive, were not prohibitive. He used the equivalent of 16 independent 64 CPUs for one to two weeks. He suggested that computing advances could cut this down by a factor of 10, which would enable the exploration of different mutations.

“The methods are now so easy to automate that we could run many, many simulations in parallel,” Tiwary explained. Machine learning makes the automation possible.

Given what he’s learned, Tiwary hopes to contribute to future drug begin that addresses mutation or resistance to treatment in other cancers. He also plans to continue to work with Seeliger to address other questions.

Next steps

Seeliger said he plans to extend this work beyond the realm of this specific type of cancer.

He will explore “how common these kinetic mutations are in other systems, other diseases and other kinases,” Seeliger said.

He would also like to understand whether other proteins in the cell help with the release of drugs or, alternatively, prevent the release of drugs from their target. The cell could have “other accessory proteins that help kick out the drug from the receptor,” Seeliger said.

The concept of drug resistance time comes from infectious disease, where microbes develop numerous mutations.

Seeliger, who is originally from Hanover, Germany, said he enjoys seeing details in any scene, even outside work, that others might not notice. 

He described how he was driving with postdoctoral fellows in Colorado when he spotted a moose. While the group stopped to take a picture, he noticed that the moose had an ear tag, which is something others didn’t immediately notice.

As for the research collaboration, Seeliger is pleased with the findings and the potential of the ongoing collaboration between experimental and computational biologists.

“The computational paper, aside from using interesting new methodology, describes why things are happening the way they are on a molecular level,” he said.

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'Spider-Man: No Way Home' will be shown at Crab Meadow Beach in Northport on July 13.

Supervisor Ed Smyth and the Town of Huntington Department of Parks and Recreation will launch the 2022 Drive-In Movies on Wednesday, July 13 at Crab Meadow Beach on Waterside Road in Northport, expanding additional movie dates to new locations across Town.

“In an effort to make Huntington’s recreational experiences more accessible, we are taking our Drive-In Movies on the road,” said Supervisor Ed Smyth. “I hope to see you all at the movies!”

The 2022 Town of Huntington Drive-In Movies lineup is as follows – all movies start at 8:30 p.m.:

Wednesday, July 13

SPIDER-MAN: NO WAY HOME

Crab Meadow Beach

Waterside Road, Northport

Wednesday, July 27

GREASE

West Neck Beach

West Neck Road, Lloyd Harbor

Wednesday, August 3

STAR WARS: THE LAST JEDI

Dix Hills Park

Vanderbilt Parkway, Dix Hills

Wednesday, August 10

BLACK PANTHER

Huntington Senior Center

423 Park Avenue, Huntington

Wednesday, August 17

ENCANTO

Huntington Senior Center

423 Park Avenue, Huntington

*Admittance is free and limited to Town of Huntington residents.

Gates open at 6 p.m. and movies start at dusk (approximately 8:30  p.m). Movies are shown on a 40-foot screen, easily seen from all parking spots.

Movie audio will be broadcast on FM radio frequency (channel 99.3) to watch the movie from a vehicle. There will also be speakers for attendees who bring lawn chairs to sit outside.

For information, or in the case of inclement weather, please check out the Parks & Rec Facebook page or visit huntingtonny.gov/parks

For up-to-the-minute movie information, call (631) 351-3089.

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